-- dump date   	20140618_225100
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1192196000001	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1192196000002	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1192196000003	OxaA-like protein precursor; Validated; Region: PRK02944
1192196000004	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
1192196000005	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1192196000006	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1192196000007	G-X-X-G motif; other site
1192196000008	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1192196000009	RxxxH motif; other site
1192196000010	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1192196000011	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1192196000012	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1192196000013	G1 box; other site
1192196000014	GTP/Mg2+ binding site [chemical binding]; other site
1192196000015	Switch I region; other site
1192196000016	G2 box; other site
1192196000017	Switch II region; other site
1192196000018	G3 box; other site
1192196000019	G4 box; other site
1192196000020	G5 box; other site
1192196000021	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1192196000022	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1192196000023	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1192196000024	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1192196000025	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1192196000026	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196000027	S-adenosylmethionine binding site [chemical binding]; other site
1192196000028	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1192196000029	ParB-like nuclease domain; Region: ParB; smart00470
1192196000030	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
1192196000031	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1192196000032	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1192196000033	P-loop; other site
1192196000034	Magnesium ion binding site [ion binding]; other site
1192196000035	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1192196000036	Magnesium ion binding site [ion binding]; other site
1192196000037	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1192196000038	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1192196000039	ParB-like nuclease domain; Region: ParB; smart00470
1192196000040	KorB domain; Region: KorB; pfam08535
1192196000041	RNA island O
1192196000042	GTP-binding protein YchF; Reviewed; Region: PRK09601
1192196000043	YchF GTPase; Region: YchF; cd01900
1192196000044	G1 box; other site
1192196000045	GTP/Mg2+ binding site [chemical binding]; other site
1192196000046	Switch I region; other site
1192196000047	G2 box; other site
1192196000048	Switch II region; other site
1192196000049	G3 box; other site
1192196000050	G4 box; other site
1192196000051	G5 box; other site
1192196000052	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1192196000053	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1192196000054	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1192196000055	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1192196000056	dimer interface [polypeptide binding]; other site
1192196000057	ssDNA binding site [nucleotide binding]; other site
1192196000058	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1192196000059	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1192196000060	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1192196000061	active site
1192196000062	putative catalytic site [active]
1192196000063	DNA binding site [nucleotide binding]
1192196000064	putative phosphate binding site [ion binding]; other site
1192196000065	metal binding site A [ion binding]; metal-binding site
1192196000066	AP binding site [nucleotide binding]; other site
1192196000067	metal binding site B [ion binding]; metal-binding site
1192196000068	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1192196000069	DNA binding site [nucleotide binding]
1192196000070	domain linker motif; other site
1192196000071	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1192196000072	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1192196000073	putative dimerization interface [polypeptide binding]; other site
1192196000074	putative ligand binding site [chemical binding]; other site
1192196000075	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196000076	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
1192196000077	putative metal binding site [ion binding]; other site
1192196000078	maltose O-acetyltransferase; Provisional; Region: PRK10092
1192196000079	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1192196000080	active site
1192196000081	substrate binding site [chemical binding]; other site
1192196000082	trimer interface [polypeptide binding]; other site
1192196000083	CoA binding site [chemical binding]; other site
1192196000084	benzoate transport; Region: 2A0115; TIGR00895
1192196000085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000086	putative substrate translocation pore; other site
1192196000087	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000088	CAAX protease self-immunity; Region: Abi; pfam02517
1192196000089	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1192196000090	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
1192196000091	catalytic residues [active]
1192196000092	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1192196000093	EamA-like transporter family; Region: EamA; pfam00892
1192196000094	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1192196000095	EamA-like transporter family; Region: EamA; pfam00892
1192196000096	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1192196000097	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1192196000098	DNA binding residues [nucleotide binding]
1192196000099	putative dimer interface [polypeptide binding]; other site
1192196000100	Putative amidase domain; Region: Amidase_6; pfam12671
1192196000101	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1192196000102	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000103	putative substrate translocation pore; other site
1192196000104	RNA island A
1192196000105	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196000106	Coenzyme A binding pocket [chemical binding]; other site
1192196000107	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196000108	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196000109	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1192196000110	putative dimerization interface [polypeptide binding]; other site
1192196000111	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000112	putative substrate translocation pore; other site
1192196000113	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196000114	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1192196000115	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1192196000116	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1192196000117	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
1192196000118	SnoaL-like domain; Region: SnoaL_3; pfam13474
1192196000119	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1192196000120	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1192196000121	DNA binding residues [nucleotide binding]
1192196000122	dimer interface [polypeptide binding]; other site
1192196000123	D-galactonate transporter; Region: 2A0114; TIGR00893
1192196000124	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000125	putative substrate translocation pore; other site
1192196000126	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1192196000127	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1192196000128	DHHA2 domain; Region: DHHA2; pfam02833
1192196000129	Predicted transcriptional regulators [Transcription]; Region: COG1733
1192196000130	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1192196000131	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1192196000132	Predicted membrane protein [Function unknown]; Region: COG4241
1192196000133	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1192196000134	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1192196000135	DHH family; Region: DHH; pfam01368
1192196000136	DHHA1 domain; Region: DHHA1; pfam02272
1192196000137	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1192196000138	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1192196000139	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1192196000140	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1192196000141	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1192196000142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000143	cyanate transporter; Region: CynX; TIGR00896
1192196000144	putative substrate translocation pore; other site
1192196000145	YycC-like protein; Region: YycC; pfam14174
1192196000146	replicative DNA helicase; Provisional; Region: PRK05748
1192196000147	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1192196000148	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1192196000149	Walker A motif; other site
1192196000150	ATP binding site [chemical binding]; other site
1192196000151	Walker B motif; other site
1192196000152	DNA binding loops [nucleotide binding]
1192196000153	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196000154	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1192196000155	active site
1192196000156	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1192196000157	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1192196000158	GDP-binding site [chemical binding]; other site
1192196000159	ACT binding site; other site
1192196000160	IMP binding site; other site
1192196000161	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1192196000162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196000163	active site
1192196000164	phosphorylation site [posttranslational modification]
1192196000165	intermolecular recognition site; other site
1192196000166	dimerization interface [polypeptide binding]; other site
1192196000167	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1192196000168	DNA binding site [nucleotide binding]
1192196000169	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1192196000170	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196000171	dimerization interface [polypeptide binding]; other site
1192196000172	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196000173	putative active site [active]
1192196000174	heme pocket [chemical binding]; other site
1192196000175	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196000176	dimer interface [polypeptide binding]; other site
1192196000177	phosphorylation site [posttranslational modification]
1192196000178	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196000179	ATP binding site [chemical binding]; other site
1192196000180	Mg2+ binding site [ion binding]; other site
1192196000181	G-X-G motif; other site
1192196000182	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
1192196000183	YycH protein; Region: YycH; pfam07435
1192196000184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853
1192196000185	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1192196000186	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
1192196000187	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1192196000188	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1192196000189	protein binding site [polypeptide binding]; other site
1192196000190	Predicted membrane protein [Function unknown]; Region: COG3212
1192196000191	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1192196000192	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1192196000193	Predicted membrane protein [Function unknown]; Region: COG3212
1192196000194	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1192196000195	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1192196000196	Predicted membrane protein [Function unknown]; Region: COG3212
1192196000197	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1192196000198	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1192196000199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196000200	active site
1192196000201	dimerization interface [polypeptide binding]; other site
1192196000202	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196000203	dimerization interface [polypeptide binding]; other site
1192196000204	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196000205	dimer interface [polypeptide binding]; other site
1192196000206	phosphorylation site [posttranslational modification]
1192196000207	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196000208	ATP binding site [chemical binding]; other site
1192196000209	Mg2+ binding site [ion binding]; other site
1192196000210	G-X-G motif; other site
1192196000211	RNA island SL
1192196000212	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1192196000213	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1192196000214	inhibitor-cofactor binding pocket; inhibition site
1192196000215	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196000216	catalytic residue [active]
1192196000217	S-methylmethionine transporter; Provisional; Region: PRK11387
1192196000218	Arginase family; Region: Arginase; cd09989
1192196000219	agmatinase; Region: agmatinase; TIGR01230
1192196000220	active site
1192196000221	Mn binding site [ion binding]; other site
1192196000222	oligomer interface [polypeptide binding]; other site
1192196000223	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1192196000224	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196000225	binding surface
1192196000226	TPR motif; other site
1192196000227	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1192196000228	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196000229	Coenzyme A binding pocket [chemical binding]; other site
1192196000230	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
1192196000231	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
1192196000232	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
1192196000233	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
1192196000234	NAD binding site [chemical binding]; other site
1192196000235	catalytic Zn binding site [ion binding]; other site
1192196000236	structural Zn binding site [ion binding]; other site
1192196000237	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
1192196000238	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1192196000239	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196000240	Walker A/P-loop; other site
1192196000241	ATP binding site [chemical binding]; other site
1192196000242	Protein of unknown function (DUF3732); Region: DUF3732; pfam12532
1192196000243	RNA island J
1192196000244	RNA island W
1192196000245	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1192196000246	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1192196000247	catalytic residue [active]
1192196000248	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1192196000249	catalytic residues [active]
1192196000250	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1192196000251	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1192196000252	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1192196000253	gluconate transporter; Region: gntP; TIGR00791
1192196000254	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1192196000255	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1192196000256	N- and C-terminal domain interface [polypeptide binding]; other site
1192196000257	active site
1192196000258	catalytic site [active]
1192196000259	metal binding site [ion binding]; metal-binding site
1192196000260	carbohydrate binding site [chemical binding]; other site
1192196000261	ATP binding site [chemical binding]; other site
1192196000262	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1192196000263	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196000264	DNA-binding site [nucleotide binding]; DNA binding site
1192196000265	FCD domain; Region: FCD; pfam07729
1192196000266	Glycerate kinase family; Region: Gly_kinase; pfam02595
1192196000267	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
1192196000268	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1192196000269	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1192196000270	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1192196000271	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196000272	MarR family; Region: MarR; pfam01047
1192196000273	short chain dehydrogenase; Provisional; Region: PRK07109
1192196000274	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
1192196000275	putative NAD(P) binding site [chemical binding]; other site
1192196000276	active site
1192196000277	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196000278	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196000279	Cupin domain; Region: Cupin_2; pfam07883
1192196000280	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1192196000281	Predicted membrane protein [Function unknown]; Region: COG2311
1192196000282	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1192196000283	RDD family; Region: RDD; pfam06271
1192196000284	FOG: WD40-like repeat [Function unknown]; Region: COG1520
1192196000285	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1192196000286	active site
1192196000287	Trp docking motif [polypeptide binding]; other site
1192196000288	RDD family; Region: RDD; pfam06271
1192196000289	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1192196000290	Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134
1192196000291	NAD(P) binding site [chemical binding]; other site
1192196000292	catalytic residues [active]
1192196000293	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196000294	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196000295	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196000296	short chain dehydrogenase; Validated; Region: PRK08589
1192196000297	classical (c) SDRs; Region: SDR_c; cd05233
1192196000298	NAD(P) binding site [chemical binding]; other site
1192196000299	active site
1192196000300	heat shock protein 90; Provisional; Region: PRK05218
1192196000301	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196000302	ATP binding site [chemical binding]; other site
1192196000303	Mg2+ binding site [ion binding]; other site
1192196000304	G-X-G motif; other site
1192196000305	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1192196000306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000307	putative substrate translocation pore; other site
1192196000308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000309	Protein of unknown function (DUF2653); Region: DUF2653; pfam10850
1192196000310	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1192196000311	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1192196000312	active site
1192196000313	catalytic tetrad [active]
1192196000314	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1192196000315	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1192196000316	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1192196000317	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1192196000318	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1192196000319	tetrameric interface [polypeptide binding]; other site
1192196000320	NAD binding site [chemical binding]; other site
1192196000321	catalytic residues [active]
1192196000322	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1192196000323	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1192196000324	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1192196000325	substrate binding site [chemical binding]; other site
1192196000326	ATP binding site [chemical binding]; other site
1192196000327	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1192196000328	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1192196000329	PYR/PP interface [polypeptide binding]; other site
1192196000330	dimer interface [polypeptide binding]; other site
1192196000331	TPP binding site [chemical binding]; other site
1192196000332	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1192196000333	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1192196000334	TPP-binding site; other site
1192196000335	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1192196000336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000337	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196000338	putative substrate translocation pore; other site
1192196000339	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1192196000340	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1192196000341	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1192196000342	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1192196000343	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1192196000344	DNA interaction; other site
1192196000345	Metal-binding active site; metal-binding site
1192196000346	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1192196000347	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1192196000348	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1192196000349	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1192196000350	intersubunit interface [polypeptide binding]; other site
1192196000351	active site
1192196000352	zinc binding site [ion binding]; other site
1192196000353	Na+ binding site [ion binding]; other site
1192196000354	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1192196000355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196000356	active site
1192196000357	phosphorylation site [posttranslational modification]
1192196000358	intermolecular recognition site; other site
1192196000359	dimerization interface [polypeptide binding]; other site
1192196000360	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1192196000361	DNA binding site [nucleotide binding]
1192196000362	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1192196000363	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
1192196000364	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196000365	ATP binding site [chemical binding]; other site
1192196000366	Mg2+ binding site [ion binding]; other site
1192196000367	G-X-G motif; other site
1192196000368	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1192196000369	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1192196000370	Walker A/P-loop; other site
1192196000371	ATP binding site [chemical binding]; other site
1192196000372	Q-loop/lid; other site
1192196000373	ABC transporter signature motif; other site
1192196000374	Walker B; other site
1192196000375	D-loop; other site
1192196000376	H-loop/switch region; other site
1192196000377	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
1192196000378	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1192196000379	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1192196000380	putative ligand binding residues [chemical binding]; other site
1192196000381	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1192196000382	Protein of unknown function (DUF3255); Region: DUF3255; pfam11631
1192196000383	sugar phosphate phosphatase; Provisional; Region: PRK10513
1192196000384	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196000385	active site
1192196000386	motif I; other site
1192196000387	motif II; other site
1192196000388	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196000389	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1192196000390	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1192196000391	active site
1192196000392	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1192196000393	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1192196000394	active site
1192196000395	non-prolyl cis peptide bond; other site
1192196000396	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196000397	Coenzyme A binding pocket [chemical binding]; other site
1192196000398	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1192196000399	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1192196000400	substrate binding pocket [chemical binding]; other site
1192196000401	membrane-bound complex binding site; other site
1192196000402	hinge residues; other site
1192196000403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196000404	dimer interface [polypeptide binding]; other site
1192196000405	conserved gate region; other site
1192196000406	putative PBP binding loops; other site
1192196000407	ABC-ATPase subunit interface; other site
1192196000408	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1192196000409	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1192196000410	Walker A/P-loop; other site
1192196000411	ATP binding site [chemical binding]; other site
1192196000412	Q-loop/lid; other site
1192196000413	ABC transporter signature motif; other site
1192196000414	Walker B; other site
1192196000415	D-loop; other site
1192196000416	H-loop/switch region; other site
1192196000417	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1192196000418	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1192196000419	metal binding site [ion binding]; metal-binding site
1192196000420	dimer interface [polypeptide binding]; other site
1192196000421	MmgE/PrpD family; Region: MmgE_PrpD; pfam03972
1192196000422	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
1192196000423	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1192196000424	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1192196000425	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1192196000426	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1192196000427	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196000428	DNA binding residues [nucleotide binding]
1192196000429	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1192196000430	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1192196000431	intersubunit interface [polypeptide binding]; other site
1192196000432	active site
1192196000433	catalytic residue [active]
1192196000434	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1192196000435	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1192196000436	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1192196000437	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1192196000438	RNA island I
1192196000439	RNA island H
1192196000440	RNA island G
1192196000441	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1192196000442	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1192196000443	active site turn [active]
1192196000444	phosphorylation site [posttranslational modification]
1192196000445	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1192196000446	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1192196000447	HPr interaction site; other site
1192196000448	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1192196000449	active site
1192196000450	phosphorylation site [posttranslational modification]
1192196000451	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1192196000452	beta-galactosidase; Region: BGL; TIGR03356
1192196000453	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1192196000454	Ligand Binding Site [chemical binding]; other site
1192196000455	Biofilm formation and stress response factor; Region: BsmA; pfam10014
1192196000456	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1192196000457	classical (c) SDRs; Region: SDR_c; cd05233
1192196000458	NAD(P) binding site [chemical binding]; other site
1192196000459	active site
1192196000460	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1192196000461	EamA-like transporter family; Region: EamA; pfam00892
1192196000462	EamA-like transporter family; Region: EamA; pfam00892
1192196000463	Protein of unknown function (DUF2716); Region: DUF2716; pfam10898
1192196000464	YxiJ-like protein; Region: YxiJ; pfam14176
1192196000465	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
1192196000466	Predicted transcriptional regulators [Transcription]; Region: COG1695
1192196000467	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1192196000468	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
1192196000469	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1192196000470	active site
1192196000471	catalytic triad [active]
1192196000472	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1192196000473	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1192196000474	ATP binding site [chemical binding]; other site
1192196000475	Mg++ binding site [ion binding]; other site
1192196000476	motif III; other site
1192196000477	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1192196000478	nucleotide binding region [chemical binding]; other site
1192196000479	ATP-binding site [chemical binding]; other site
1192196000480	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
1192196000481	RNA binding site [nucleotide binding]; other site
1192196000482	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1192196000483	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000484	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1192196000485	CAT RNA binding domain; Region: CAT_RBD; pfam03123
1192196000486	PRD domain; Region: PRD; pfam00874
1192196000487	PRD domain; Region: PRD; pfam00874
1192196000488	citrate transporter, CitMHS family; Region: citMHS; TIGR00784
1192196000489	Citrate transporter; Region: CitMHS; pfam03600
1192196000490	hydroperoxidase II; Provisional; Region: katE; PRK11249
1192196000491	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
1192196000492	tetramer interface [polypeptide binding]; other site
1192196000493	heme binding pocket [chemical binding]; other site
1192196000494	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1192196000495	domain interactions; other site
1192196000496	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
1192196000497	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1192196000498	nucleoside transporter; Region: nupC; TIGR00804
1192196000499	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1192196000500	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1192196000501	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1192196000502	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1192196000503	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1192196000504	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1192196000505	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1192196000506	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1192196000507	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
1192196000508	NAD binding site [chemical binding]; other site
1192196000509	homotetramer interface [polypeptide binding]; other site
1192196000510	homodimer interface [polypeptide binding]; other site
1192196000511	substrate binding site [chemical binding]; other site
1192196000512	active site
1192196000513	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1192196000514	substrate binding site [chemical binding]; other site
1192196000515	THF binding site; other site
1192196000516	zinc-binding site [ion binding]; other site
1192196000517	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1192196000518	substrate binding site [chemical binding]; other site
1192196000519	zinc-binding site [ion binding]; other site
1192196000520	Tubby C 2; Region: Tub_2; cl02043
1192196000521	peptidase T; Region: peptidase-T; TIGR01882
1192196000522	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1192196000523	metal binding site [ion binding]; metal-binding site
1192196000524	dimer interface [polypeptide binding]; other site
1192196000525	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1192196000526	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196000527	active site
1192196000528	phosphorylation site [posttranslational modification]
1192196000529	intermolecular recognition site; other site
1192196000530	dimerization interface [polypeptide binding]; other site
1192196000531	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1192196000532	DNA binding residues [nucleotide binding]
1192196000533	dimerization interface [polypeptide binding]; other site
1192196000534	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1192196000535	Histidine kinase; Region: HisKA_3; pfam07730
1192196000536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196000537	ATP binding site [chemical binding]; other site
1192196000538	Mg2+ binding site [ion binding]; other site
1192196000539	G-X-G motif; other site
1192196000540	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1192196000541	UDP-glucose 4-epimerase; Region: PLN02240
1192196000542	NAD binding site [chemical binding]; other site
1192196000543	homodimer interface [polypeptide binding]; other site
1192196000544	active site
1192196000545	substrate binding site [chemical binding]; other site
1192196000546	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1192196000547	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1192196000548	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1192196000549	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1192196000550	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1192196000551	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1192196000552	NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151
1192196000553	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1192196000554	NAD(P) binding site [chemical binding]; other site
1192196000555	catalytic residues [active]
1192196000556	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1192196000557	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1192196000558	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1192196000559	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1192196000560	Walker A/P-loop; other site
1192196000561	ATP binding site [chemical binding]; other site
1192196000562	Q-loop/lid; other site
1192196000563	ABC transporter signature motif; other site
1192196000564	Walker B; other site
1192196000565	D-loop; other site
1192196000566	H-loop/switch region; other site
1192196000567	TOBE domain; Region: TOBE; pfam03459
1192196000568	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1192196000569	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1192196000570	putative active site [active]
1192196000571	putative metal binding site [ion binding]; other site
1192196000572	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1192196000573	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
1192196000574	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1192196000575	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1192196000576	cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203
1192196000577	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1192196000578	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1192196000579	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1192196000580	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196000581	ATP binding site [chemical binding]; other site
1192196000582	Q-loop/lid; other site
1192196000583	ABC transporter signature motif; other site
1192196000584	Walker B; other site
1192196000585	D-loop; other site
1192196000586	H-loop/switch region; other site
1192196000587	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1192196000588	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1192196000589	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
1192196000590	Walker A/P-loop; other site
1192196000591	ATP binding site [chemical binding]; other site
1192196000592	Q-loop/lid; other site
1192196000593	ABC transporter signature motif; other site
1192196000594	Walker B; other site
1192196000595	D-loop; other site
1192196000596	H-loop/switch region; other site
1192196000597	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1192196000598	putative substrate binding site [chemical binding]; other site
1192196000599	putative ATP binding site [chemical binding]; other site
1192196000600	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
1192196000601	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1192196000602	Na binding site [ion binding]; other site
1192196000603	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
1192196000604	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196000605	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196000606	DNA binding residues [nucleotide binding]
1192196000607	Exoribonuclease II [Transcription]; Region: Rnb; COG4776
1192196000608	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1192196000609	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1192196000610	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1192196000611	Walker A/P-loop; other site
1192196000612	ATP binding site [chemical binding]; other site
1192196000613	Q-loop/lid; other site
1192196000614	ABC transporter signature motif; other site
1192196000615	Walker B; other site
1192196000616	D-loop; other site
1192196000617	H-loop/switch region; other site
1192196000618	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1192196000619	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000620	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196000621	putative substrate translocation pore; other site
1192196000622	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1192196000623	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
1192196000624	tetramer interface [polypeptide binding]; other site
1192196000625	heme binding pocket [chemical binding]; other site
1192196000626	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1192196000627	active site
1192196000628	DNA binding site [nucleotide binding]
1192196000629	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1192196000630	HTH domain; Region: HTH_11; pfam08279
1192196000631	Mga helix-turn-helix domain; Region: Mga; pfam05043
1192196000632	PRD domain; Region: PRD; pfam00874
1192196000633	PRD domain; Region: PRD; pfam00874
1192196000634	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1192196000635	active site
1192196000636	P-loop; other site
1192196000637	phosphorylation site [posttranslational modification]
1192196000638	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1192196000639	active site
1192196000640	phosphorylation site [posttranslational modification]
1192196000641	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1192196000642	active site
1192196000643	P-loop; other site
1192196000644	phosphorylation site [posttranslational modification]
1192196000645	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1192196000646	PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410
1192196000647	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1192196000648	methionine cluster; other site
1192196000649	active site
1192196000650	phosphorylation site [posttranslational modification]
1192196000651	metal binding site [ion binding]; metal-binding site
1192196000652	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1192196000653	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1192196000654	NAD binding site [chemical binding]; other site
1192196000655	sugar binding site [chemical binding]; other site
1192196000656	divalent metal binding site [ion binding]; other site
1192196000657	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1192196000658	dimer interface [polypeptide binding]; other site
1192196000659	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1192196000660	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1192196000661	homodimer interface [polypeptide binding]; other site
1192196000662	substrate-cofactor binding pocket; other site
1192196000663	catalytic residue [active]
1192196000664	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
1192196000665	classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370
1192196000666	putative NAD(P) binding site [chemical binding]; other site
1192196000667	active site
1192196000668	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
1192196000669	DltD N-terminal region; Region: DltD_N; pfam04915
1192196000670	DltD central region; Region: DltD_M; pfam04918
1192196000671	DltD C-terminal region; Region: DltD_C; pfam04914
1192196000672	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1192196000673	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1192196000674	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1192196000675	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1192196000676	acyl-activating enzyme (AAE) consensus motif; other site
1192196000677	AMP binding site [chemical binding]; other site
1192196000678	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1192196000679	UbiA prenyltransferase family; Region: UbiA; pfam01040
1192196000680	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1192196000681	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1192196000682	synthetase active site [active]
1192196000683	NTP binding site [chemical binding]; other site
1192196000684	metal binding site [ion binding]; metal-binding site
1192196000685	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000686	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1192196000687	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1192196000688	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1192196000689	salt bridge; other site
1192196000690	non-specific DNA binding site [nucleotide binding]; other site
1192196000691	sequence-specific DNA binding site [nucleotide binding]; other site
1192196000692	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1192196000693	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1192196000694	PA/protease domain interface [polypeptide binding]; other site
1192196000695	putative integrin binding motif; other site
1192196000696	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
1192196000697	Peptidase family M28; Region: Peptidase_M28; pfam04389
1192196000698	metal binding site [ion binding]; metal-binding site
1192196000699	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
1192196000700	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1192196000701	active site
1192196000702	HIGH motif; other site
1192196000703	dimer interface [polypeptide binding]; other site
1192196000704	KMSKS motif; other site
1192196000705	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1192196000706	RNA binding surface [nucleotide binding]; other site
1192196000707	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196000708	MarR family; Region: MarR; pfam01047
1192196000709	Predicted integral membrane protein [Function unknown]; Region: COG5522
1192196000710	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1192196000711	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1192196000712	Ligand binding site; other site
1192196000713	metal-binding site
1192196000714	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1192196000715	CAT RNA binding domain; Region: CAT_RBD; pfam03123
1192196000716	PRD domain; Region: PRD; pfam00874
1192196000717	PRD domain; Region: PRD; pfam00874
1192196000718	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1192196000719	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1192196000720	active site turn [active]
1192196000721	phosphorylation site [posttranslational modification]
1192196000722	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1192196000723	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1192196000724	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1192196000725	active site
1192196000726	catalytic residues [active]
1192196000727	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1192196000728	PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410
1192196000729	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196000730	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1192196000731	active site
1192196000732	metal binding site [ion binding]; metal-binding site
1192196000733	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1192196000734	PUA domain; Region: PUA; cl00607
1192196000735	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1192196000736	putative RNA binding site [nucleotide binding]; other site
1192196000737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196000738	S-adenosylmethionine binding site [chemical binding]; other site
1192196000739	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
1192196000740	sugar efflux transporter; Region: 2A0120; TIGR00899
1192196000741	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000742	putative substrate translocation pore; other site
1192196000743	TIGR00659 family protein; Region: TIGR00659
1192196000744	holin-like protein; Validated; Region: PRK01658
1192196000745	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196000746	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196000747	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1192196000748	putative dimerization interface [polypeptide binding]; other site
1192196000749	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1192196000750	substrate binding site [chemical binding]; other site
1192196000751	multimerization interface [polypeptide binding]; other site
1192196000752	ATP binding site [chemical binding]; other site
1192196000753	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1192196000754	thiamine phosphate binding site [chemical binding]; other site
1192196000755	active site
1192196000756	pyrophosphate binding site [ion binding]; other site
1192196000757	FTR1 family protein; Region: TIGR00145
1192196000758	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
1192196000759	Imelysin; Region: Peptidase_M75; pfam09375
1192196000760	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1192196000761	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1192196000762	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1192196000763	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1192196000764	catalytic residues [active]
1192196000765	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1192196000766	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1192196000767	Na binding site [ion binding]; other site
1192196000768	Predicted membrane protein [Function unknown]; Region: COG3162
1192196000769	Anti-repressor SinI; Region: SinI; pfam08671
1192196000770	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196000771	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196000772	Predicted membrane protein [Function unknown]; Region: COG2246
1192196000773	GtrA-like protein; Region: GtrA; pfam04138
1192196000774	galactokinase; Provisional; Region: PRK05322
1192196000775	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1192196000776	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1192196000777	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1192196000778	Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468
1192196000779	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1192196000780	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
1192196000781	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
1192196000782	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
1192196000783	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1192196000784	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1192196000785	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1192196000786	D-pathway; other site
1192196000787	Putative ubiquinol binding site [chemical binding]; other site
1192196000788	Low-spin heme (heme b) binding site [chemical binding]; other site
1192196000789	Putative water exit pathway; other site
1192196000790	Binuclear center (heme o3/CuB) [ion binding]; other site
1192196000791	K-pathway; other site
1192196000792	Putative proton exit pathway; other site
1192196000793	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1192196000794	Subunit I/III interface [polypeptide binding]; other site
1192196000795	Subunit III/IV interface [polypeptide binding]; other site
1192196000796	cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901
1192196000797	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
1192196000798	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1192196000799	dimer interface [polypeptide binding]; other site
1192196000800	FMN binding site [chemical binding]; other site
1192196000801	NADPH bind site [chemical binding]; other site
1192196000802	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1192196000803	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1192196000804	Bacterial protein of unknown function (HtrL_YibB); Region: HtrL_YibB; cl08171
1192196000805	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1192196000806	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1192196000807	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1192196000808	putative active site [active]
1192196000809	catalytic triad [active]
1192196000810	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1192196000811	PA/protease domain interface [polypeptide binding]; other site
1192196000812	putative integrin binding motif; other site
1192196000813	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1192196000814	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1192196000815	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1192196000816	CAT RNA binding domain; Region: CAT_RBD; smart01061
1192196000817	PRD domain; Region: PRD; pfam00874
1192196000818	PRD domain; Region: PRD; pfam00874
1192196000819	formate/nitrite transporter; Region: fnt; TIGR00790
1192196000820	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1192196000821	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1192196000822	active site turn [active]
1192196000823	phosphorylation site [posttranslational modification]
1192196000824	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1192196000825	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1192196000826	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1192196000827	substrate binding [chemical binding]; other site
1192196000828	active site
1192196000829	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1192196000830	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1192196000831	dimer interface [polypeptide binding]; other site
1192196000832	substrate binding site [chemical binding]; other site
1192196000833	ATP binding site [chemical binding]; other site
1192196000834	Predicted transcriptional regulators [Transcription]; Region: COG1695
1192196000835	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196000836	putative DNA binding site [nucleotide binding]; other site
1192196000837	putative Zn2+ binding site [ion binding]; other site
1192196000838	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1192196000839	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1192196000840	active site
1192196000841	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1192196000842	ligand binding site [chemical binding]; other site
1192196000843	active site
1192196000844	UGI interface [polypeptide binding]; other site
1192196000845	catalytic site [active]
1192196000846	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1192196000847	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1192196000848	NAD(P) binding site [chemical binding]; other site
1192196000849	catalytic residues [active]
1192196000850	Permease family; Region: Xan_ur_permease; pfam00860
1192196000851	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1192196000852	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671
1192196000853	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1192196000854	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1192196000855	active site
1192196000856	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1192196000857	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
1192196000858	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1192196000859	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1192196000860	inhibitor-cofactor binding pocket; inhibition site
1192196000861	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196000862	catalytic residue [active]
1192196000863	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1192196000864	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196000865	Coenzyme A binding pocket [chemical binding]; other site
1192196000866	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
1192196000867	NeuB family; Region: NeuB; pfam03102
1192196000868	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
1192196000869	NeuB binding interface [polypeptide binding]; other site
1192196000870	putative substrate binding site [chemical binding]; other site
1192196000871	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
1192196000872	ligand binding site; other site
1192196000873	Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980
1192196000874	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1192196000875	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1192196000876	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1192196000877	substrate binding site; other site
1192196000878	tetramer interface; other site
1192196000879	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1192196000880	dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181
1192196000881	NAD binding site [chemical binding]; other site
1192196000882	substrate binding site [chemical binding]; other site
1192196000883	homodimer interface [polypeptide binding]; other site
1192196000884	active site
1192196000885	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
1192196000886	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1192196000887	NADP binding site [chemical binding]; other site
1192196000888	active site
1192196000889	putative substrate binding site [chemical binding]; other site
1192196000890	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1192196000891	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
1192196000892	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1192196000893	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1192196000894	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1192196000895	NAD(P) binding site [chemical binding]; other site
1192196000896	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1192196000897	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1192196000898	Glutamate binding site [chemical binding]; other site
1192196000899	homodimer interface [polypeptide binding]; other site
1192196000900	NAD binding site [chemical binding]; other site
1192196000901	catalytic residues [active]
1192196000902	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
1192196000903	putative metal binding site [ion binding]; other site
1192196000904	putative dimer interface [polypeptide binding]; other site
1192196000905	S-methylmethionine transporter; Provisional; Region: PRK11387
1192196000906	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1192196000907	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000908	putative substrate translocation pore; other site
1192196000909	Prephenate dehydratase; Region: PDT; pfam00800
1192196000910	Cupin domain; Region: Cupin_2; pfam07883
1192196000911	Cupin domain; Region: Cupin_2; pfam07883
1192196000912	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1192196000913	classical (c) SDRs; Region: SDR_c; cd05233
1192196000914	NAD(P) binding site [chemical binding]; other site
1192196000915	active site
1192196000916	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
1192196000917	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1192196000918	H+ Antiporter protein; Region: 2A0121; TIGR00900
1192196000919	transaminase; Reviewed; Region: PRK08068
1192196000920	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196000921	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196000922	homodimer interface [polypeptide binding]; other site
1192196000923	catalytic residue [active]
1192196000924	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1192196000925	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1192196000926	putative NAD(P) binding site [chemical binding]; other site
1192196000927	putative active site [active]
1192196000928	putative heme peroxidase; Provisional; Region: PRK12276
1192196000929	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1192196000930	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196000931	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196000932	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1192196000933	putative dimerization interface [polypeptide binding]; other site
1192196000934	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1192196000935	EamA-like transporter family; Region: EamA; pfam00892
1192196000936	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1192196000937	EamA-like transporter family; Region: EamA; pfam00892
1192196000938	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1192196000939	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1192196000940	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
1192196000941	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1192196000942	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1192196000943	Zn2+ binding site [ion binding]; other site
1192196000944	Mg2+ binding site [ion binding]; other site
1192196000945	Uncharacterized conserved protein [Function unknown]; Region: COG3465
1192196000946	Rrf2 family protein; Region: rrf2_super; TIGR00738
1192196000947	Transcriptional regulator; Region: Rrf2; pfam02082
1192196000948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196000949	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196000950	putative substrate translocation pore; other site
1192196000951	threonyl-tRNA synthetase; Reviewed; Region: PRK12444
1192196000952	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1192196000953	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1192196000954	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1192196000955	active site
1192196000956	dimer interface [polypeptide binding]; other site
1192196000957	motif 1; other site
1192196000958	motif 2; other site
1192196000959	motif 3; other site
1192196000960	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1192196000961	anticodon binding site; other site
1192196000962	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196000963	MarR family; Region: MarR; pfam01047
1192196000964	MarR family; Region: MarR_2; cl17246
1192196000965	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
1192196000966	active site 1 [active]
1192196000967	dimer interface [polypeptide binding]; other site
1192196000968	hexamer interface [polypeptide binding]; other site
1192196000969	active site 2 [active]
1192196000970	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1192196000971	Peptidase family M50; Region: Peptidase_M50; pfam02163
1192196000972	active site
1192196000973	putative substrate binding region [chemical binding]; other site
1192196000974	YwhD family; Region: YwhD; pfam08741
1192196000975	Transglycosylase; Region: Transgly; pfam00912
1192196000976	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1192196000977	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1192196000978	spermidine synthase; Provisional; Region: PRK00811
1192196000979	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196000980	agmatinase; Region: agmatinase; TIGR01230
1192196000981	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
1192196000982	putative active site [active]
1192196000983	Mn binding site [ion binding]; other site
1192196000984	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1192196000985	Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131
1192196000986	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1192196000987	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196000988	TPR motif; other site
1192196000989	binding surface
1192196000990	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1192196000991	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1192196000992	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1192196000993	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1192196000994	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1192196000995	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1192196000996	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1192196000997	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1192196000998	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1192196000999	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1192196001000	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1192196001001	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1192196001002	Walker A/P-loop; other site
1192196001003	ATP binding site [chemical binding]; other site
1192196001004	Q-loop/lid; other site
1192196001005	ABC transporter signature motif; other site
1192196001006	Walker B; other site
1192196001007	D-loop; other site
1192196001008	H-loop/switch region; other site
1192196001009	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
1192196001010	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1192196001011	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196001012	FeS/SAM binding site; other site
1192196001013	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1192196001014	Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420
1192196001015	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
1192196001016	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1192196001017	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1192196001018	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1192196001019	active site
1192196001020	HIGH motif; other site
1192196001021	KMSK motif region; other site
1192196001022	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1192196001023	tRNA binding surface [nucleotide binding]; other site
1192196001024	anticodon binding site; other site
1192196001025	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1192196001026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196001027	putative substrate translocation pore; other site
1192196001028	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1192196001029	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1192196001030	ligand binding site [chemical binding]; other site
1192196001031	flexible hinge region; other site
1192196001032	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1192196001033	putative switch regulator; other site
1192196001034	non-specific DNA interactions [nucleotide binding]; other site
1192196001035	DNA binding site [nucleotide binding]
1192196001036	sequence specific DNA binding site [nucleotide binding]; other site
1192196001037	putative cAMP binding site [chemical binding]; other site
1192196001038	YwiC-like protein; Region: YwiC; pfam14256
1192196001039	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1192196001040	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
1192196001041	ligand binding site [chemical binding]; other site
1192196001042	flexible hinge region; other site
1192196001043	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
1192196001044	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1192196001045	[4Fe-4S] binding site [ion binding]; other site
1192196001046	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1192196001047	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1192196001048	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1192196001049	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1192196001050	molybdopterin cofactor binding site; other site
1192196001051	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1192196001052	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1192196001053	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
1192196001054	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1192196001055	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1192196001056	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1192196001057	putative active site [active]
1192196001058	catalytic site [active]
1192196001059	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1192196001060	putative active site [active]
1192196001061	catalytic site [active]
1192196001062	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1192196001063	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1192196001064	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1192196001065	Walker A/P-loop; other site
1192196001066	ATP binding site [chemical binding]; other site
1192196001067	Q-loop/lid; other site
1192196001068	ABC transporter signature motif; other site
1192196001069	Walker B; other site
1192196001070	D-loop; other site
1192196001071	H-loop/switch region; other site
1192196001072	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1192196001073	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
1192196001074	folate binding site [chemical binding]; other site
1192196001075	NADP+ binding site [chemical binding]; other site
1192196001076	UV damage endonuclease UvdE; Region: uvde; TIGR00629
1192196001077	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1192196001078	putative active site [active]
1192196001079	catalytic site [active]
1192196001080	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1192196001081	PLD-like domain; Region: PLDc_2; pfam13091
1192196001082	putative active site [active]
1192196001083	catalytic site [active]
1192196001084	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1192196001085	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1192196001086	FAD binding site [chemical binding]; other site
1192196001087	homotetramer interface [polypeptide binding]; other site
1192196001088	substrate binding pocket [chemical binding]; other site
1192196001089	catalytic base [active]
1192196001090	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1192196001091	CTP synthetase; Validated; Region: pyrG; PRK05380
1192196001092	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1192196001093	Catalytic site [active]
1192196001094	active site
1192196001095	UTP binding site [chemical binding]; other site
1192196001096	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1192196001097	active site
1192196001098	putative oxyanion hole; other site
1192196001099	catalytic triad [active]
1192196001100	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
1192196001101	Response regulator receiver domain; Region: Response_reg; pfam00072
1192196001102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196001103	active site
1192196001104	phosphorylation site [posttranslational modification]
1192196001105	intermolecular recognition site; other site
1192196001106	dimerization interface [polypeptide binding]; other site
1192196001107	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1192196001108	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1192196001109	intersubunit interface [polypeptide binding]; other site
1192196001110	active site
1192196001111	zinc binding site [ion binding]; other site
1192196001112	Na+ binding site [ion binding]; other site
1192196001113	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1192196001114	active site
1192196001115	intersubunit interactions; other site
1192196001116	catalytic residue [active]
1192196001117	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1192196001118	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1192196001119	hinge; other site
1192196001120	active site
1192196001121	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1192196001122	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1192196001123	putative active site [active]
1192196001124	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1192196001125	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1192196001126	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1192196001127	RNA binding site [nucleotide binding]; other site
1192196001128	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1192196001129	multimer interface [polypeptide binding]; other site
1192196001130	Walker A motif; other site
1192196001131	ATP binding site [chemical binding]; other site
1192196001132	Walker B motif; other site
1192196001133	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1192196001134	thymidine kinase; Provisional; Region: PRK04296
1192196001135	malate dehydrogenase; Provisional; Region: PRK13529
1192196001136	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1192196001137	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1192196001138	NAD(P) binding site [chemical binding]; other site
1192196001139	he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946
1192196001140	polar chromosome segregation protein; Reviewed; Region: racA; PRK13182
1192196001141	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
1192196001142	DNA binding residues [nucleotide binding]
1192196001143	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1192196001144	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196001145	putative metal binding site [ion binding]; other site
1192196001146	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1192196001147	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1192196001148	RF-1 domain; Region: RF-1; pfam00472
1192196001149	HemK family putative methylases; Region: hemK_fam; TIGR00536
1192196001150	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196001151	S-adenosylmethionine binding site [chemical binding]; other site
1192196001152	stage II sporulation protein R; Region: spore_II_R; TIGR02837
1192196001153	N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246
1192196001154	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1192196001155	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1192196001156	Predicted membrane protein [Function unknown]; Region: COG1971
1192196001157	Domain of unknown function DUF; Region: DUF204; pfam02659
1192196001158	Domain of unknown function DUF; Region: DUF204; pfam02659
1192196001159	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1192196001160	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1192196001161	active site
1192196001162	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1192196001163	hypothetical protein; Provisional; Region: PRK13690
1192196001164	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1192196001165	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1192196001166	dimer interface [polypeptide binding]; other site
1192196001167	active site
1192196001168	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1192196001169	folate binding site [chemical binding]; other site
1192196001170	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1192196001171	active site
1192196001172	ATP synthase I chain; Region: ATP_synt_I; pfam03899
1192196001173	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1192196001174	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1192196001175	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1192196001176	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1192196001177	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1192196001178	ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145
1192196001179	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1192196001180	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1192196001181	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1192196001182	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1192196001183	beta subunit interaction interface [polypeptide binding]; other site
1192196001184	Walker A motif; other site
1192196001185	ATP binding site [chemical binding]; other site
1192196001186	Walker B motif; other site
1192196001187	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1192196001188	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1192196001189	core domain interface [polypeptide binding]; other site
1192196001190	delta subunit interface [polypeptide binding]; other site
1192196001191	epsilon subunit interface [polypeptide binding]; other site
1192196001192	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1192196001193	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1192196001194	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1192196001195	alpha subunit interaction interface [polypeptide binding]; other site
1192196001196	Walker A motif; other site
1192196001197	ATP binding site [chemical binding]; other site
1192196001198	Walker B motif; other site
1192196001199	inhibitor binding site; inhibition site
1192196001200	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1192196001201	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1192196001202	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1192196001203	gamma subunit interface [polypeptide binding]; other site
1192196001204	epsilon subunit interface [polypeptide binding]; other site
1192196001205	LBP interface [polypeptide binding]; other site
1192196001206	Predicted membrane protein [Function unknown]; Region: COG4836
1192196001207	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
1192196001208	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1192196001209	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1192196001210	hinge; other site
1192196001211	active site
1192196001212	stage II sporulation protein D; Region: spore_II_D; TIGR02870
1192196001213	Stage II sporulation protein; Region: SpoIID; pfam08486
1192196001214	VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456
1192196001215	metal ion-dependent adhesion site (MIDAS); other site
1192196001216	VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456
1192196001217	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1192196001218	metal ion-dependent adhesion site (MIDAS); other site
1192196001219	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1192196001220	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1192196001221	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196001222	FeS/SAM binding site; other site
1192196001223	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1192196001224	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196001225	binding surface
1192196001226	TPR motif; other site
1192196001227	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1192196001228	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196001229	binding surface
1192196001230	TPR motif; other site
1192196001231	CsbD-like; Region: CsbD; pfam05532
1192196001232	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1192196001233	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1192196001234	alpha-gamma subunit interface [polypeptide binding]; other site
1192196001235	beta-gamma subunit interface [polypeptide binding]; other site
1192196001236	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1192196001237	gamma-beta subunit interface [polypeptide binding]; other site
1192196001238	alpha-beta subunit interface [polypeptide binding]; other site
1192196001239	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1192196001240	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1192196001241	subunit interactions [polypeptide binding]; other site
1192196001242	active site
1192196001243	flap region; other site
1192196001244	Predicted transcriptional regulator [Transcription]; Region: COG1959
1192196001245	Transcriptional regulator; Region: Rrf2; pfam02082
1192196001246	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1192196001247	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1192196001248	active site
1192196001249	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1192196001250	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1192196001251	DNA binding residues [nucleotide binding]
1192196001252	dimer interface [polypeptide binding]; other site
1192196001253	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1192196001254	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1192196001255	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1192196001256	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1192196001257	putative active site [active]
1192196001258	catalytic site [active]
1192196001259	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1192196001260	putative active site [active]
1192196001261	catalytic site [active]
1192196001262	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1192196001263	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196001264	Coenzyme A binding pocket [chemical binding]; other site
1192196001265	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1192196001266	Peptidase family M23; Region: Peptidase_M23; pfam01551
1192196001267	Restriction endonuclease BamHI; Region: BamHI; pfam02923
1192196001268	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196001269	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1192196001270	DNA methylase; Region: N6_N4_Mtase; pfam01555
1192196001271	VanZ like family; Region: VanZ; pfam04892
1192196001272	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
1192196001273	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1192196001274	active site
1192196001275	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1192196001276	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1192196001277	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1192196001278	Isochorismatase family; Region: Isochorismatase; pfam00857
1192196001279	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1192196001280	catalytic triad [active]
1192196001281	conserved cis-peptide bond; other site
1192196001282	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196001283	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196001284	putative substrate translocation pore; other site
1192196001285	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196001286	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
1192196001287	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1192196001288	Na binding site [ion binding]; other site
1192196001289	putative substrate binding site [chemical binding]; other site
1192196001290	Right handed beta helix region; Region: Beta_helix; pfam13229
1192196001291	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196001292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196001293	putative substrate translocation pore; other site
1192196001294	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196001295	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196001296	putative Zn2+ binding site [ion binding]; other site
1192196001297	putative DNA binding site [nucleotide binding]; other site
1192196001298	Stage III sporulation protein D; Region: SpoIIID; pfam12116
1192196001299	rod shape-determining protein Mbl; Provisional; Region: PRK13928
1192196001300	MreB and similar proteins; Region: MreB_like; cd10225
1192196001301	nucleotide binding site [chemical binding]; other site
1192196001302	Mg binding site [ion binding]; other site
1192196001303	putative protofilament interaction site [polypeptide binding]; other site
1192196001304	RodZ interaction site [polypeptide binding]; other site
1192196001305	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
1192196001306	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1192196001307	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1192196001308	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
1192196001309	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
1192196001310	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196001311	binding surface
1192196001312	TPR motif; other site
1192196001313	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1192196001314	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1192196001315	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955
1192196001316	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1192196001317	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1192196001318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196001319	dimer interface [polypeptide binding]; other site
1192196001320	phosphorylation site [posttranslational modification]
1192196001321	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1192196001322	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196001323	ATP binding site [chemical binding]; other site
1192196001324	Mg2+ binding site [ion binding]; other site
1192196001325	G-X-G motif; other site
1192196001326	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1192196001327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196001328	active site
1192196001329	phosphorylation site [posttranslational modification]
1192196001330	intermolecular recognition site; other site
1192196001331	dimerization interface [polypeptide binding]; other site
1192196001332	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1192196001333	Histidine kinase; Region: His_kinase; pfam06580
1192196001334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196001335	ATP binding site [chemical binding]; other site
1192196001336	Mg2+ binding site [ion binding]; other site
1192196001337	G-X-G motif; other site
1192196001338	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
1192196001339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196001340	active site
1192196001341	phosphorylation site [posttranslational modification]
1192196001342	intermolecular recognition site; other site
1192196001343	dimerization interface [polypeptide binding]; other site
1192196001344	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1192196001345	DNA binding site [nucleotide binding]
1192196001346	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
1192196001347	Collagen binding domain; Region: Collagen_bind; pfam05737
1192196001348	Collagen binding domain; Region: Collagen_bind; pfam05737
1192196001349	Collagen binding domain; Region: Collagen_bind; pfam05737
1192196001350	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
1192196001351	Collagen binding domain; Region: Collagen_bind; pfam05737
1192196001352	Cna protein B-type domain; Region: Cna_B; pfam05738
1192196001353	Cna protein B-type domain; Region: Cna_B; pfam05738
1192196001354	Cna protein B-type domain; Region: Cna_B; pfam05738
1192196001355	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
1192196001356	Cna protein B-type domain; Region: Cna_B; pfam05738
1192196001357	Cna protein B-type domain; Region: Cna_B; pfam05738
1192196001358	Cna protein B-type domain; Region: Cna_B; pfam05738
1192196001359	Cna protein B-type domain; Region: Cna_B; pfam05738
1192196001360	Cna protein B-type domain; Region: Cna_B; pfam05738
1192196001361	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
1192196001362	active site
1192196001363	catalytic site [active]
1192196001364	YwpF-like protein; Region: YwpF; pfam14183
1192196001365	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1192196001366	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1192196001367	dimer interface [polypeptide binding]; other site
1192196001368	ssDNA binding site [nucleotide binding]; other site
1192196001369	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1192196001370	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1192196001371	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1192196001372	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1192196001373	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196001374	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1192196001375	active site
1192196001376	motif I; other site
1192196001377	motif II; other site
1192196001378	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196001379	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1192196001380	SNF2 Helicase protein; Region: DUF3670; pfam12419
1192196001381	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1192196001382	ATP binding site [chemical binding]; other site
1192196001383	putative Mg++ binding site [ion binding]; other site
1192196001384	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1192196001385	nucleotide binding region [chemical binding]; other site
1192196001386	ATP-binding site [chemical binding]; other site
1192196001387	SWIM zinc finger; Region: SWIM; pfam04434
1192196001388	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1192196001389	Chain length determinant protein; Region: Wzz; cl15801
1192196001390	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1192196001391	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1192196001392	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1192196001393	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1192196001394	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1192196001395	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1192196001396	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1192196001397	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
1192196001398	LXG domain of WXG superfamily; Region: LXG; pfam04740
1192196001399	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
1192196001400	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
1192196001401	Active_site [active]
1192196001402	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196001403	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196001404	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1192196001405	dimerization interface [polypeptide binding]; other site
1192196001406	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1192196001407	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1192196001408	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1192196001409	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1192196001410	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1192196001411	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196001412	putative DNA binding site [nucleotide binding]; other site
1192196001413	putative Zn2+ binding site [ion binding]; other site
1192196001414	AsnC family; Region: AsnC_trans_reg; pfam01037
1192196001415	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1192196001416	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
1192196001417	Domain of unknown function (DUF4181); Region: DUF4181; pfam13789
1192196001418	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1192196001419	CotH protein; Region: CotH; pfam08757
1192196001420	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1192196001421	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1192196001422	transmembrane helices; other site
1192196001423	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1192196001424	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196001425	The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452
1192196001426	putative dimerization interface [polypeptide binding]; other site
1192196001427	putative substrate binding pocket [chemical binding]; other site
1192196001428	acetolactate synthase; Reviewed; Region: PRK08617
1192196001429	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1192196001430	PYR/PP interface [polypeptide binding]; other site
1192196001431	dimer interface [polypeptide binding]; other site
1192196001432	TPP binding site [chemical binding]; other site
1192196001433	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1192196001434	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1192196001435	TPP-binding site [chemical binding]; other site
1192196001436	dimer interface [polypeptide binding]; other site
1192196001437	alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252
1192196001438	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1192196001439	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1192196001440	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
1192196001441	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1192196001442	Bacterial SH3 domain; Region: SH3_3; cl17532
1192196001443	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
1192196001444	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1192196001445	ligand binding site [chemical binding]; other site
1192196001446	dimerization interface [polypeptide binding]; other site
1192196001447	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1192196001448	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1192196001449	TM-ABC transporter signature motif; other site
1192196001450	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1192196001451	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1192196001452	Walker A/P-loop; other site
1192196001453	ATP binding site [chemical binding]; other site
1192196001454	Q-loop/lid; other site
1192196001455	ABC transporter signature motif; other site
1192196001456	Walker B; other site
1192196001457	D-loop; other site
1192196001458	H-loop/switch region; other site
1192196001459	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1192196001460	D-ribose pyranase; Provisional; Region: PRK11797
1192196001461	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1192196001462	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1192196001463	substrate binding site [chemical binding]; other site
1192196001464	dimer interface [polypeptide binding]; other site
1192196001465	ATP binding site [chemical binding]; other site
1192196001466	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1192196001467	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1192196001468	DNA binding site [nucleotide binding]
1192196001469	domain linker motif; other site
1192196001470	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1192196001471	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
1192196001472	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1192196001473	poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011
1192196001474	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
1192196001475	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1192196001476	putative active site [active]
1192196001477	putative metal binding site [ion binding]; other site
1192196001478	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1192196001479	NlpC/P60 family; Region: NLPC_P60; pfam00877
1192196001480	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1192196001481	NlpC/P60 family; Region: NLPC_P60; pfam00877
1192196001482	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1192196001483	NlpC/P60 family; Region: NLPC_P60; pfam00877
1192196001484	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196001485	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1192196001486	active site
1192196001487	motif I; other site
1192196001488	motif II; other site
1192196001489	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1192196001490	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1192196001491	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1192196001492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196001493	putative substrate translocation pore; other site
1192196001494	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1192196001495	Spore germination protein; Region: Spore_permease; pfam03845
1192196001496	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1192196001497	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1192196001498	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1192196001499	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1192196001500	Bacterial SH3 domain; Region: SH3_3; pfam08239
1192196001501	Lysozyme subfamily 2; Region: LYZ2; smart00047
1192196001502	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1192196001503	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1192196001504	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1192196001505	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1192196001506	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
1192196001507	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1192196001508	putative NAD(P) binding site [chemical binding]; other site
1192196001509	putative catalytic Zn binding site [ion binding]; other site
1192196001510	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1192196001511	substrate binding site; other site
1192196001512	dimer interface; other site
1192196001513	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1192196001514	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1192196001515	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1192196001516	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1192196001517	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1192196001518	active site
1192196001519	HIGH motif; other site
1192196001520	nucleotide binding site [chemical binding]; other site
1192196001521	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1192196001522	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1192196001523	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1192196001524	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1192196001525	active site
1192196001526	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1192196001527	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1192196001528	active site
1192196001529	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1192196001530	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1192196001531	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1192196001532	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1192196001533	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1192196001534	Walker A/P-loop; other site
1192196001535	ATP binding site [chemical binding]; other site
1192196001536	Q-loop/lid; other site
1192196001537	ABC transporter signature motif; other site
1192196001538	Walker B; other site
1192196001539	D-loop; other site
1192196001540	H-loop/switch region; other site
1192196001541	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1192196001542	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1192196001543	active site
1192196001544	tetramer interface; other site
1192196001545	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1192196001546	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1192196001547	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1192196001548	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1192196001549	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1192196001550	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1192196001551	active site
1192196001552	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
1192196001553	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1192196001554	active site
1192196001555	homodimer interface [polypeptide binding]; other site
1192196001556	membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379
1192196001557	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1192196001558	Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247
1192196001559	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1192196001560	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1192196001561	Stage II sporulation protein; Region: SpoIID; pfam08486
1192196001562	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
1192196001563	Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247
1192196001564	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1192196001565	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1192196001566	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1192196001567	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1192196001568	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1192196001569	active site
1192196001570	metal binding site [ion binding]; metal-binding site
1192196001571	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1192196001572	active site
1192196001573	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1192196001574	colanic acid exporter; Provisional; Region: PRK10459
1192196001575	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1192196001576	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1192196001577	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
1192196001578	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1192196001579	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1192196001580	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1192196001581	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1192196001582	Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297
1192196001583	O-Antigen ligase; Region: Wzy_C; pfam04932
1192196001584	Chain length determinant protein; Region: Wzz; cl15801
1192196001585	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
1192196001586	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1192196001587	putative homodimer interface [polypeptide binding]; other site
1192196001588	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1192196001589	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1192196001590	Mg++ binding site [ion binding]; other site
1192196001591	putative catalytic motif [active]
1192196001592	substrate binding site [chemical binding]; other site
1192196001593	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1192196001594	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
1192196001595	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1192196001596	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1192196001597	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1192196001598	Histidine kinase; Region: HisKA_3; pfam07730
1192196001599	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196001600	ATP binding site [chemical binding]; other site
1192196001601	Mg2+ binding site [ion binding]; other site
1192196001602	G-X-G motif; other site
1192196001603	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1192196001604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196001605	active site
1192196001606	phosphorylation site [posttranslational modification]
1192196001607	intermolecular recognition site; other site
1192196001608	dimerization interface [polypeptide binding]; other site
1192196001609	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1192196001610	DNA binding residues [nucleotide binding]
1192196001611	dimerization interface [polypeptide binding]; other site
1192196001612	EDD domain protein, DegV family; Region: DegV; TIGR00762
1192196001613	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1192196001614	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
1192196001615	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1192196001616	ATP binding site [chemical binding]; other site
1192196001617	putative Mg++ binding site [ion binding]; other site
1192196001618	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1192196001619	nucleotide binding region [chemical binding]; other site
1192196001620	ATP-binding site [chemical binding]; other site
1192196001621	Late competence development protein ComFB; Region: ComFB; pfam10719
1192196001622	comF family protein; Region: comF; TIGR00201
1192196001623	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1192196001624	active site
1192196001625	flagellar operon protein TIGR03826; Region: YvyF
1192196001626	Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747
1192196001627	FlgN protein; Region: FlgN; pfam05130
1192196001628	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
1192196001629	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1192196001630	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
1192196001631	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1192196001632	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1192196001633	flagellar assembly protein FliW; Provisional; Region: PRK13285
1192196001634	carbon storage regulator; Provisional; Region: PRK01712
1192196001635	flagellin; Provisional; Region: PRK12804
1192196001636	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1192196001637	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1192196001638	flagellar protein FlaG; Provisional; Region: PRK07738
1192196001639	flagellar capping protein; Validated; Region: fliD; PRK07737
1192196001640	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1192196001641	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1192196001642	flagellar biosynthetic protein FliS; Region: fliS; TIGR00208
1192196001643	Flagellar protein FliT; Region: FliT; pfam05400
1192196001644	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1192196001645	30S subunit binding site; other site
1192196001646	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1192196001647	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1192196001648	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1192196001649	nucleotide binding region [chemical binding]; other site
1192196001650	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1192196001651	ATP-binding site [chemical binding]; other site
1192196001652	SEC-C motif; Region: SEC-C; pfam02810
1192196001653	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1192196001654	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1192196001655	RF-1 domain; Region: RF-1; pfam00472
1192196001656	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1192196001657	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1192196001658	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1192196001659	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1192196001660	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1192196001661	Cytochrome c; Region: Cytochrom_C; pfam00034
1192196001662	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1192196001663	ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292
1192196001664	Walker A/P-loop; other site
1192196001665	ATP binding site [chemical binding]; other site
1192196001666	Q-loop/lid; other site
1192196001667	ABC transporter signature motif; other site
1192196001668	Walker B; other site
1192196001669	D-loop; other site
1192196001670	H-loop/switch region; other site
1192196001671	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1192196001672	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1192196001673	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1192196001674	C-terminal peptidase (prc); Region: prc; TIGR00225
1192196001675	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1192196001676	protein binding site [polypeptide binding]; other site
1192196001677	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1192196001678	Catalytic dyad [active]
1192196001679	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1192196001680	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1192196001681	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1192196001682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196001683	putative substrate translocation pore; other site
1192196001684	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196001685	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196001686	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1192196001687	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
1192196001688	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1192196001689	excinuclease ABC subunit B; Provisional; Region: PRK05298
1192196001690	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1192196001691	ATP binding site [chemical binding]; other site
1192196001692	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1192196001693	nucleotide binding region [chemical binding]; other site
1192196001694	ATP-binding site [chemical binding]; other site
1192196001695	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1192196001696	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1192196001697	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1192196001698	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1192196001699	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1192196001700	flagellin; Provisional; Region: PRK12804
1192196001701	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1192196001702	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1192196001703	Uncharacterized conserved protein [Function unknown]; Region: COG3595
1192196001704	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1192196001705	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
1192196001706	Predicted membrane protein [Function unknown]; Region: COG1950
1192196001707	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196001708	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196001709	putative substrate translocation pore; other site
1192196001710	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196001711	MarR family; Region: MarR; pfam01047
1192196001712	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1192196001713	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196001714	DNA-binding site [nucleotide binding]; DNA binding site
1192196001715	UTRA domain; Region: UTRA; pfam07702
1192196001716	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1192196001717	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1192196001718	active site
1192196001719	trimer interface [polypeptide binding]; other site
1192196001720	allosteric site; other site
1192196001721	active site lid [active]
1192196001722	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1192196001723	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
1192196001724	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1192196001725	active site
1192196001726	dimer interface [polypeptide binding]; other site
1192196001727	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1192196001728	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1192196001729	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1192196001730	Hpr binding site; other site
1192196001731	active site
1192196001732	homohexamer subunit interaction site [polypeptide binding]; other site
1192196001733	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1192196001734	Nucleoside recognition; Region: Gate; pfam07670
1192196001735	Nucleoside recognition; Region: Gate; pfam07670
1192196001736	pyrophosphatase PpaX; Provisional; Region: PRK13288
1192196001737	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196001738	motif II; other site
1192196001739	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1192196001740	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1192196001741	CoA binding site [chemical binding]; other site
1192196001742	active site
1192196001743	Pectate lyase; Region: Pectate_lyase; pfam03211
1192196001744	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
1192196001745	putative active site [active]
1192196001746	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
1192196001747	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1192196001748	dimer interface [polypeptide binding]; other site
1192196001749	motif 1; other site
1192196001750	active site
1192196001751	motif 2; other site
1192196001752	motif 3; other site
1192196001753	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1192196001754	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1192196001755	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1192196001756	histidinol dehydrogenase; Region: hisD; TIGR00069
1192196001757	NAD binding site [chemical binding]; other site
1192196001758	dimerization interface [polypeptide binding]; other site
1192196001759	product binding site; other site
1192196001760	substrate binding site [chemical binding]; other site
1192196001761	zinc binding site [ion binding]; other site
1192196001762	catalytic residues [active]
1192196001763	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1192196001764	putative active site pocket [active]
1192196001765	4-fold oligomerization interface [polypeptide binding]; other site
1192196001766	metal binding residues [ion binding]; metal-binding site
1192196001767	3-fold/trimer interface [polypeptide binding]; other site
1192196001768	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1192196001769	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1192196001770	putative active site [active]
1192196001771	oxyanion strand; other site
1192196001772	catalytic triad [active]
1192196001773	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1192196001774	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1192196001775	catalytic residues [active]
1192196001776	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1192196001777	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1192196001778	substrate binding site [chemical binding]; other site
1192196001779	glutamase interaction surface [polypeptide binding]; other site
1192196001780	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1192196001781	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1192196001782	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1192196001783	metal binding site [ion binding]; metal-binding site
1192196001784	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1192196001785	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1192196001786	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196001787	Walker A/P-loop; other site
1192196001788	ATP binding site [chemical binding]; other site
1192196001789	Q-loop/lid; other site
1192196001790	ABC transporter signature motif; other site
1192196001791	Walker B; other site
1192196001792	D-loop; other site
1192196001793	H-loop/switch region; other site
1192196001794	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196001795	binding surface
1192196001796	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1192196001797	TPR motif; other site
1192196001798	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1192196001799	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196001800	TPR motif; other site
1192196001801	binding surface
1192196001802	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1192196001803	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1192196001804	NlpC/P60 family; Region: NLPC_P60; pfam00877
1192196001805	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1192196001806	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1192196001807	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1192196001808	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1192196001809	putative active site [active]
1192196001810	nucleotide binding site [chemical binding]; other site
1192196001811	nudix motif; other site
1192196001812	putative metal binding site [ion binding]; other site
1192196001813	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
1192196001814	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1192196001815	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1192196001816	phosphate binding site [ion binding]; other site
1192196001817	putative substrate binding pocket [chemical binding]; other site
1192196001818	dimer interface [polypeptide binding]; other site
1192196001819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1192196001820	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1192196001821	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1192196001822	dimerization domain swap beta strand [polypeptide binding]; other site
1192196001823	regulatory protein interface [polypeptide binding]; other site
1192196001824	active site
1192196001825	regulatory phosphorylation site [posttranslational modification]; other site
1192196001826	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1192196001827	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1192196001828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196001829	active site
1192196001830	phosphorylation site [posttranslational modification]
1192196001831	intermolecular recognition site; other site
1192196001832	dimerization interface [polypeptide binding]; other site
1192196001833	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1192196001834	DNA binding site [nucleotide binding]
1192196001835	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1192196001836	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
1192196001837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196001838	ATP binding site [chemical binding]; other site
1192196001839	Mg2+ binding site [ion binding]; other site
1192196001840	G-X-G motif; other site
1192196001841	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1192196001842	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1192196001843	Walker A/P-loop; other site
1192196001844	ATP binding site [chemical binding]; other site
1192196001845	Q-loop/lid; other site
1192196001846	ABC transporter signature motif; other site
1192196001847	Walker B; other site
1192196001848	D-loop; other site
1192196001849	H-loop/switch region; other site
1192196001850	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1192196001851	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1192196001852	dimerization interface [polypeptide binding]; other site
1192196001853	ligand binding site [chemical binding]; other site
1192196001854	NADP binding site [chemical binding]; other site
1192196001855	catalytic site [active]
1192196001856	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1192196001857	active site clefts [active]
1192196001858	zinc binding site [ion binding]; other site
1192196001859	dimer interface [polypeptide binding]; other site
1192196001860	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1192196001861	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1192196001862	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1192196001863	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1192196001864	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
1192196001865	metal binding site [ion binding]; metal-binding site
1192196001866	TIGR00730 family protein; Region: TIGR00730
1192196001867	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1192196001868	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1192196001869	DNA binding site [nucleotide binding]
1192196001870	domain linker motif; other site
1192196001871	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1192196001872	ligand binding site [chemical binding]; other site
1192196001873	dimerization interface [polypeptide binding]; other site
1192196001874	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1192196001875	homodimer interface [polypeptide binding]; other site
1192196001876	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1192196001877	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1192196001878	active site
1192196001879	homodimer interface [polypeptide binding]; other site
1192196001880	catalytic site [active]
1192196001881	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1192196001882	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1192196001883	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1192196001884	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196001885	dimer interface [polypeptide binding]; other site
1192196001886	conserved gate region; other site
1192196001887	putative PBP binding loops; other site
1192196001888	ABC-ATPase subunit interface; other site
1192196001889	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1192196001890	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196001891	dimer interface [polypeptide binding]; other site
1192196001892	conserved gate region; other site
1192196001893	ABC-ATPase subunit interface; other site
1192196001894	Predicted integral membrane protein [Function unknown]; Region: COG5521
1192196001895	maltose phosphorylase; Provisional; Region: PRK13807
1192196001896	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1192196001897	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1192196001898	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1192196001899	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1192196001900	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1192196001901	Ca binding site [ion binding]; other site
1192196001902	active site
1192196001903	catalytic site [active]
1192196001904	beta-phosphoglucomutase; Region: bPGM; TIGR01990
1192196001905	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196001906	motif II; other site
1192196001907	Clp protease; Region: CLP_protease; pfam00574
1192196001908	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1192196001909	oligomer interface [polypeptide binding]; other site
1192196001910	active site residues [active]
1192196001911	Patatin [General function prediction only]; Region: COG3621
1192196001912	Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213
1192196001913	active site
1192196001914	nucleophile elbow; other site
1192196001915	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1192196001916	FAD binding domain; Region: FAD_binding_4; pfam01565
1192196001917	Berberine and berberine like; Region: BBE; pfam08031
1192196001918	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1192196001919	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1192196001920	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1192196001921	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196001922	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196001923	amino acid transporter; Region: 2A0306; TIGR00909
1192196001924	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1192196001925	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1192196001926	substrate binding [chemical binding]; other site
1192196001927	active site
1192196001928	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1192196001929	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
1192196001930	active site
1192196001931	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1192196001932	Beta-lactamase; Region: Beta-lactamase; pfam00144
1192196001933	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
1192196001934	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1192196001935	aspartate racemase; Region: asp_race; TIGR00035
1192196001936	Protein of unknown function (DUF3237); Region: DUF3237; cl07905
1192196001937	Protein of unknown function (DUF3237); Region: DUF3237; cl07905
1192196001938	Phenolic acid decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3479
1192196001939	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1192196001940	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1192196001941	substrate binding pocket [chemical binding]; other site
1192196001942	catalytic triad [active]
1192196001943	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1192196001944	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1192196001945	non-specific DNA binding site [nucleotide binding]; other site
1192196001946	salt bridge; other site
1192196001947	sequence-specific DNA binding site [nucleotide binding]; other site
1192196001948	Anti-repressor SinI; Region: SinI; pfam08671
1192196001949	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1192196001950	Chain length determinant protein; Region: Wzz; cl15801
1192196001951	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
1192196001952	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1192196001953	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1192196001954	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1192196001955	NAD(P) binding site [chemical binding]; other site
1192196001956	homodimer interface [polypeptide binding]; other site
1192196001957	substrate binding site [chemical binding]; other site
1192196001958	active site
1192196001959	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1192196001960	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1192196001961	putative ADP-binding pocket [chemical binding]; other site
1192196001962	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1192196001963	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1192196001964	active site
1192196001965	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1192196001966	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
1192196001967	putative ADP-binding pocket [chemical binding]; other site
1192196001968	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1192196001969	active site
1192196001970	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
1192196001971	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1192196001972	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1192196001973	active site
1192196001974	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
1192196001975	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1192196001976	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1192196001977	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1192196001978	putative trimer interface [polypeptide binding]; other site
1192196001979	putative CoA binding site [chemical binding]; other site
1192196001980	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
1192196001981	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1192196001982	inhibitor-cofactor binding pocket; inhibition site
1192196001983	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196001984	catalytic residue [active]
1192196001985	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
1192196001986	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1192196001987	YvfG protein; Region: YvfG; pfam09628
1192196001988	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
1192196001989	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1192196001990	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1192196001991	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1192196001992	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1192196001993	L-lactate permease; Region: Lactate_perm; pfam02652
1192196001994	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1192196001995	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1192196001996	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1192196001997	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1192196001998	DNA binding site [nucleotide binding]
1192196001999	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1192196002000	putative dimerization interface [polypeptide binding]; other site
1192196002001	putative ligand binding site [chemical binding]; other site
1192196002002	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1192196002003	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1192196002004	TM2 domain; Region: TM2; pfam05154
1192196002005	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196002006	dimer interface [polypeptide binding]; other site
1192196002007	conserved gate region; other site
1192196002008	ABC-ATPase subunit interface; other site
1192196002009	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1192196002010	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196002011	dimer interface [polypeptide binding]; other site
1192196002012	conserved gate region; other site
1192196002013	putative PBP binding loops; other site
1192196002014	ABC-ATPase subunit interface; other site
1192196002015	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1192196002016	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1192196002017	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1192196002018	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1192196002019	Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867
1192196002020	PAS domain S-box; Region: sensory_box; TIGR00229
1192196002021	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196002022	putative active site [active]
1192196002023	heme pocket [chemical binding]; other site
1192196002024	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1192196002025	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
1192196002026	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1192196002027	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1192196002028	catalytic site [active]
1192196002029	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1192196002030	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1192196002031	Walker A/P-loop; other site
1192196002032	ATP binding site [chemical binding]; other site
1192196002033	Q-loop/lid; other site
1192196002034	ABC transporter signature motif; other site
1192196002035	Walker B; other site
1192196002036	D-loop; other site
1192196002037	H-loop/switch region; other site
1192196002038	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1192196002039	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1192196002040	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1192196002041	Histidine kinase; Region: HisKA_3; pfam07730
1192196002042	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196002043	ATP binding site [chemical binding]; other site
1192196002044	Mg2+ binding site [ion binding]; other site
1192196002045	G-X-G motif; other site
1192196002046	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1192196002047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196002048	active site
1192196002049	phosphorylation site [posttranslational modification]
1192196002050	intermolecular recognition site; other site
1192196002051	dimerization interface [polypeptide binding]; other site
1192196002052	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1192196002053	DNA binding residues [nucleotide binding]
1192196002054	dimerization interface [polypeptide binding]; other site
1192196002055	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
1192196002056	Cysteine-rich domain; Region: CCG; pfam02754
1192196002057	Cysteine-rich domain; Region: CCG; pfam02754
1192196002058	iron-sulfur cluster-binding protein; Region: TIGR00273
1192196002059	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1192196002060	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1192196002061	Uncharacterized conserved protein [Function unknown]; Region: COG1556
1192196002062	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1192196002063	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1192196002064	active site
1192196002065	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1192196002066	EamA-like transporter family; Region: EamA; pfam00892
1192196002067	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1192196002068	EamA-like transporter family; Region: EamA; pfam00892
1192196002069	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196002070	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196002071	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1192196002072	dimerization interface [polypeptide binding]; other site
1192196002073	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1192196002074	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1192196002075	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1192196002076	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196002077	DNA-binding site [nucleotide binding]; DNA binding site
1192196002078	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1192196002079	Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541
1192196002080	putative dimerization interface [polypeptide binding]; other site
1192196002081	putative ligand binding site [chemical binding]; other site
1192196002082	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
1192196002083	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196002084	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196002085	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1192196002086	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1192196002087	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1192196002088	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1192196002089	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1192196002090	Phosphoglycerate kinase; Region: PGK; pfam00162
1192196002091	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1192196002092	substrate binding site [chemical binding]; other site
1192196002093	hinge regions; other site
1192196002094	ADP binding site [chemical binding]; other site
1192196002095	catalytic site [active]
1192196002096	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1192196002097	dimer interface [polypeptide binding]; other site
1192196002098	substrate binding site [chemical binding]; other site
1192196002099	catalytic triad [active]
1192196002100	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1192196002101	phosphoglyceromutase; Provisional; Region: PRK05434
1192196002102	enolase; Provisional; Region: eno; PRK00077
1192196002103	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1192196002104	dimer interface [polypeptide binding]; other site
1192196002105	metal binding site [ion binding]; metal-binding site
1192196002106	substrate binding pocket [chemical binding]; other site
1192196002107	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196002108	Coenzyme A binding pocket [chemical binding]; other site
1192196002109	Predicted membrane protein [Function unknown]; Region: COG4640
1192196002110	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1192196002111	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1192196002112	Double zinc ribbon; Region: DZR; pfam12773
1192196002113	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1192196002114	pentamer interface [polypeptide binding]; other site
1192196002115	dodecaamer interface [polypeptide binding]; other site
1192196002116	YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724
1192196002117	membrane protein, MarC family; Region: TIGR00427
1192196002118	Predicted transcriptional regulators [Transcription]; Region: COG1510
1192196002119	MarR family; Region: MarR_2; pfam12802
1192196002120	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1192196002121	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
1192196002122	Walker A/P-loop; other site
1192196002123	ATP binding site [chemical binding]; other site
1192196002124	Q-loop/lid; other site
1192196002125	ABC transporter signature motif; other site
1192196002126	Walker B; other site
1192196002127	D-loop; other site
1192196002128	H-loop/switch region; other site
1192196002129	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1192196002130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1192196002131	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1192196002132	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196002133	dimer interface [polypeptide binding]; other site
1192196002134	conserved gate region; other site
1192196002135	putative PBP binding loops; other site
1192196002136	ABC-ATPase subunit interface; other site
1192196002137	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196002138	dimerization interface [polypeptide binding]; other site
1192196002139	putative DNA binding site [nucleotide binding]; other site
1192196002140	putative Zn2+ binding site [ion binding]; other site
1192196002141	Predicted integral membrane protein [Function unknown]; Region: COG5658
1192196002142	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1192196002143	SdpI/YhfL protein family; Region: SdpI; pfam13630
1192196002144	antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032
1192196002145	antimicrobial peptide system protein, SdpB family; Region: export_SdpB; TIGR04033
1192196002146	antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034
1192196002147	Predicted transcriptional regulators [Transcription]; Region: COG1510
1192196002148	MarR family; Region: MarR_2; pfam12802
1192196002149	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1192196002150	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
1192196002151	Walker A/P-loop; other site
1192196002152	ATP binding site [chemical binding]; other site
1192196002153	Q-loop/lid; other site
1192196002154	ABC transporter signature motif; other site
1192196002155	Walker B; other site
1192196002156	D-loop; other site
1192196002157	H-loop/switch region; other site
1192196002158	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1192196002159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196002160	dimer interface [polypeptide binding]; other site
1192196002161	conserved gate region; other site
1192196002162	putative PBP binding loops; other site
1192196002163	ABC-ATPase subunit interface; other site
1192196002164	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1192196002165	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1192196002166	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196002167	dimer interface [polypeptide binding]; other site
1192196002168	conserved gate region; other site
1192196002169	putative PBP binding loops; other site
1192196002170	ABC-ATPase subunit interface; other site
1192196002171	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1192196002172	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196002173	dimerization interface [polypeptide binding]; other site
1192196002174	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1192196002175	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1192196002176	dimer interface [polypeptide binding]; other site
1192196002177	putative CheW interface [polypeptide binding]; other site
1192196002178	Predicted transcriptional regulators [Transcription]; Region: COG1733
1192196002179	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1192196002180	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1192196002181	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1192196002182	non-specific DNA binding site [nucleotide binding]; other site
1192196002183	salt bridge; other site
1192196002184	sequence-specific DNA binding site [nucleotide binding]; other site
1192196002185	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1192196002186	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1192196002187	non-specific DNA binding site [nucleotide binding]; other site
1192196002188	salt bridge; other site
1192196002189	sequence-specific DNA binding site [nucleotide binding]; other site
1192196002190	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1192196002191	salt bridge; other site
1192196002192	non-specific DNA binding site [nucleotide binding]; other site
1192196002193	sequence-specific DNA binding site [nucleotide binding]; other site
1192196002194	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1192196002195	Esterase/lipase [General function prediction only]; Region: COG1647
1192196002196	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1192196002197	ribonuclease R; Region: RNase_R; TIGR02063
1192196002198	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1192196002199	Cold shock protein domain; Region: CSP; smart00357
1192196002200	RNB domain; Region: RNB; pfam00773
1192196002201	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1192196002202	RNA binding site [nucleotide binding]; other site
1192196002203	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1192196002204	SmpB-tmRNA interface; other site
1192196002205	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1192196002206	classical (c) SDRs; Region: SDR_c; cd05233
1192196002207	NAD(P) binding site [chemical binding]; other site
1192196002208	active site
1192196002209	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196002210	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196002211	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1192196002212	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1192196002213	Predicted membrane protein [Function unknown]; Region: COG1289
1192196002214	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1192196002215	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1192196002216	azoreductase; Reviewed; Region: PRK00170
1192196002217	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1192196002218	putative oxidoreductase; Provisional; Region: PRK11579
1192196002219	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1192196002220	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1192196002221	Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157
1192196002222	putative homodimer interface [polypeptide binding]; other site
1192196002223	putative homotetramer interface [polypeptide binding]; other site
1192196002224	allosteric switch controlling residues; other site
1192196002225	putative metal binding site [ion binding]; other site
1192196002226	putative homodimer-homodimer interface [polypeptide binding]; other site
1192196002227	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1192196002228	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1192196002229	metal-binding site [ion binding]
1192196002230	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1192196002231	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1192196002232	metal-binding site [ion binding]
1192196002233	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1192196002234	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1192196002235	metal-binding site [ion binding]
1192196002236	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1192196002237	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1192196002238	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1192196002239	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1192196002240	metal-binding site [ion binding]
1192196002241	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1192196002242	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1192196002243	Thioredoxin; Region: Thioredoxin_4; pfam13462
1192196002244	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1192196002245	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
1192196002246	Predicted membrane protein [Function unknown]; Region: COG2860
1192196002247	UPF0126 domain; Region: UPF0126; pfam03458
1192196002248	UPF0126 domain; Region: UPF0126; pfam03458
1192196002249	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1192196002250	Part of AAA domain; Region: AAA_19; pfam13245
1192196002251	Family description; Region: UvrD_C_2; pfam13538
1192196002252	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
1192196002253	Flavodoxin; Region: Flavodoxin_1; pfam00258
1192196002254	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1192196002255	FAD binding pocket [chemical binding]; other site
1192196002256	FAD binding motif [chemical binding]; other site
1192196002257	catalytic residues [active]
1192196002258	NAD binding pocket [chemical binding]; other site
1192196002259	phosphate binding motif [ion binding]; other site
1192196002260	beta-alpha-beta structure motif; other site
1192196002261	sulfite reductase subunit beta; Provisional; Region: PRK13504
1192196002262	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1192196002263	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1192196002264	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1192196002265	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1192196002266	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1192196002267	active site
1192196002268	catalytic tetrad [active]
1192196002269	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1192196002270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196002271	dimer interface [polypeptide binding]; other site
1192196002272	conserved gate region; other site
1192196002273	putative PBP binding loops; other site
1192196002274	ABC-ATPase subunit interface; other site
1192196002275	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1192196002276	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1192196002277	DNA binding domain, excisionase family; Region: excise; TIGR01764
1192196002278	Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910
1192196002279	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1192196002280	Sulfatase; Region: Sulfatase; pfam00884
1192196002281	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1192196002282	small, acid-soluble spore protein, SspJ family; Region: spore_sspJ; TIGR02863
1192196002283	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
1192196002284	Spore germination protein; Region: Spore_permease; cl17796
1192196002285	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1192196002286	putative ligand binding residues [chemical binding]; other site
1192196002287	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1192196002288	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1192196002289	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196002290	ABC-ATPase subunit  interface; other site
1192196002291	dimer interface [polypeptide binding]; other site
1192196002292	putative PBP binding regions; other site
1192196002293	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1192196002294	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196002295	ABC-ATPase subunit  interface; other site
1192196002296	dimer interface [polypeptide binding]; other site
1192196002297	putative PBP binding regions; other site
1192196002298	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1192196002299	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1192196002300	Walker A/P-loop; other site
1192196002301	ATP binding site [chemical binding]; other site
1192196002302	Q-loop/lid; other site
1192196002303	ABC transporter signature motif; other site
1192196002304	Walker B; other site
1192196002305	D-loop; other site
1192196002306	H-loop/switch region; other site
1192196002307	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1192196002308	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1192196002309	DNA damage checkpoint protein; Region: LCD1; pfam09798
1192196002310	HlyD family secretion protein; Region: HlyD_3; pfam13437
1192196002311	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1192196002312	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1192196002313	Walker A/P-loop; other site
1192196002314	ATP binding site [chemical binding]; other site
1192196002315	Q-loop/lid; other site
1192196002316	ABC transporter signature motif; other site
1192196002317	Walker B; other site
1192196002318	D-loop; other site
1192196002319	H-loop/switch region; other site
1192196002320	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1192196002321	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1192196002322	FtsX-like permease family; Region: FtsX; pfam02687
1192196002323	Regulatory protein YrvL; Region: YrvL; pfam14184
1192196002324	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
1192196002325	Cupin; Region: Cupin_1; smart00835
1192196002326	Cupin; Region: Cupin_1; smart00835
1192196002327	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1192196002328	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196002329	DNA binding residues [nucleotide binding]
1192196002330	Response regulator receiver domain; Region: Response_reg; pfam00072
1192196002331	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196002332	active site
1192196002333	phosphorylation site [posttranslational modification]
1192196002334	intermolecular recognition site; other site
1192196002335	dimerization interface [polypeptide binding]; other site
1192196002336	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1192196002337	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1192196002338	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196002339	dimer interface [polypeptide binding]; other site
1192196002340	phosphorylation site [posttranslational modification]
1192196002341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196002342	ATP binding site [chemical binding]; other site
1192196002343	Mg2+ binding site [ion binding]; other site
1192196002344	G-X-G motif; other site
1192196002345	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1192196002346	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1192196002347	classical (c) SDRs; Region: SDR_c; cd05233
1192196002348	NAD(P) binding site [chemical binding]; other site
1192196002349	active site
1192196002350	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1192196002351	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
1192196002352	putative binding site residues; other site
1192196002353	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1192196002354	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196002355	ABC-ATPase subunit  interface; other site
1192196002356	dimer interface [polypeptide binding]; other site
1192196002357	putative PBP binding regions; other site
1192196002358	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1192196002359	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1192196002360	Walker A/P-loop; other site
1192196002361	ATP binding site [chemical binding]; other site
1192196002362	Q-loop/lid; other site
1192196002363	ABC transporter signature motif; other site
1192196002364	Walker B; other site
1192196002365	D-loop; other site
1192196002366	H-loop/switch region; other site
1192196002367	Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808
1192196002368	ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636
1192196002369	H+ Antiporter protein; Region: 2A0121; TIGR00900
1192196002370	PspA/IM30 family; Region: PspA_IM30; pfam04012
1192196002371	Uncharacterized conserved protein [Function unknown]; Region: COG3595
1192196002372	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1192196002373	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1192196002374	Predicted membrane protein [Function unknown]; Region: COG4758
1192196002375	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
1192196002376	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1192196002377	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1192196002378	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196002379	dimerization interface [polypeptide binding]; other site
1192196002380	Histidine kinase; Region: HisKA_3; pfam07730
1192196002381	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196002382	ATP binding site [chemical binding]; other site
1192196002383	Mg2+ binding site [ion binding]; other site
1192196002384	G-X-G motif; other site
1192196002385	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1192196002386	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196002387	active site
1192196002388	phosphorylation site [posttranslational modification]
1192196002389	intermolecular recognition site; other site
1192196002390	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1192196002391	DNA binding residues [nucleotide binding]
1192196002392	dimerization interface [polypeptide binding]; other site
1192196002393	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1192196002394	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1192196002395	Spore germination protein; Region: Spore_permease; pfam03845
1192196002396	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1192196002397	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1192196002398	Class II fumarases; Region: Fumarase_classII; cd01362
1192196002399	active site
1192196002400	tetramer interface [polypeptide binding]; other site
1192196002401	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196002402	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196002403	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1192196002404	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196002405	dimerization interface [polypeptide binding]; other site
1192196002406	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196002407	dimer interface [polypeptide binding]; other site
1192196002408	phosphorylation site [posttranslational modification]
1192196002409	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196002410	ATP binding site [chemical binding]; other site
1192196002411	Mg2+ binding site [ion binding]; other site
1192196002412	G-X-G motif; other site
1192196002413	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1192196002414	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196002415	active site
1192196002416	phosphorylation site [posttranslational modification]
1192196002417	intermolecular recognition site; other site
1192196002418	dimerization interface [polypeptide binding]; other site
1192196002419	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1192196002420	DNA binding site [nucleotide binding]
1192196002421	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1192196002422	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1192196002423	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1192196002424	protein binding site [polypeptide binding]; other site
1192196002425	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1192196002426	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1192196002427	dimerization interface [polypeptide binding]; other site
1192196002428	DPS ferroxidase diiron center [ion binding]; other site
1192196002429	ion pore; other site
1192196002430	short chain dehydrogenase; Provisional; Region: PRK06914
1192196002431	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1192196002432	NADP binding site [chemical binding]; other site
1192196002433	active site
1192196002434	steroid binding site; other site
1192196002435	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1192196002436	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
1192196002437	active site
1192196002438	Zn binding site [ion binding]; other site
1192196002439	YusW-like protein; Region: YusW; pfam14039
1192196002440	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1192196002441	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1192196002442	Walker A/P-loop; other site
1192196002443	ATP binding site [chemical binding]; other site
1192196002444	Q-loop/lid; other site
1192196002445	ABC transporter signature motif; other site
1192196002446	Walker B; other site
1192196002447	D-loop; other site
1192196002448	H-loop/switch region; other site
1192196002449	Protein of unknown function (DUF2573); Region: DUF2573; pfam10835
1192196002450	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196002451	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196002452	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1192196002453	dimerization interface [polypeptide binding]; other site
1192196002454	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1192196002455	classical (c) SDRs; Region: SDR_c; cd05233
1192196002456	NAD(P) binding site [chemical binding]; other site
1192196002457	active site
1192196002458	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1192196002459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196002460	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196002461	putative substrate translocation pore; other site
1192196002462	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196002463	MarR family; Region: MarR; pfam01047
1192196002464	Coat F domain; Region: Coat_F; pfam07875
1192196002465	Proline dehydrogenase; Region: Pro_dh; pfam01619
1192196002466	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1192196002467	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1192196002468	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1192196002469	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1192196002470	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1192196002471	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1192196002472	substrate binding site [chemical binding]; other site
1192196002473	oxyanion hole (OAH) forming residues; other site
1192196002474	trimer interface [polypeptide binding]; other site
1192196002475	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
1192196002476	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1192196002477	dimer interface [polypeptide binding]; other site
1192196002478	active site
1192196002479	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1192196002480	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1192196002481	active site
1192196002482	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1192196002483	ArsC family; Region: ArsC; pfam03960
1192196002484	putative ArsC-like catalytic residues; other site
1192196002485	putative TRX-like catalytic residues [active]
1192196002486	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1192196002487	lipoyl attachment site [posttranslational modification]; other site
1192196002488	Protein of unknown function (DUF2553); Region: DUF2553; pfam10830
1192196002489	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1192196002490	putative active site [active]
1192196002491	putative metal binding site [ion binding]; other site
1192196002492	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1192196002493	catalytic residues [active]
1192196002494	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1192196002495	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1192196002496	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1192196002497	Walker A/P-loop; other site
1192196002498	ATP binding site [chemical binding]; other site
1192196002499	Q-loop/lid; other site
1192196002500	ABC transporter signature motif; other site
1192196002501	Walker B; other site
1192196002502	D-loop; other site
1192196002503	H-loop/switch region; other site
1192196002504	NIL domain; Region: NIL; pfam09383
1192196002505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196002506	conserved gate region; other site
1192196002507	ABC-ATPase subunit interface; other site
1192196002508	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1192196002509	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1192196002510	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1192196002511	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1192196002512	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1192196002513	Walker A/P-loop; other site
1192196002514	ATP binding site [chemical binding]; other site
1192196002515	Q-loop/lid; other site
1192196002516	ABC transporter signature motif; other site
1192196002517	Walker B; other site
1192196002518	D-loop; other site
1192196002519	H-loop/switch region; other site
1192196002520	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1192196002521	FeS assembly protein SufD; Region: sufD; TIGR01981
1192196002522	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1192196002523	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1192196002524	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1192196002525	catalytic residue [active]
1192196002526	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1192196002527	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1192196002528	trimerization site [polypeptide binding]; other site
1192196002529	active site
1192196002530	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1192196002531	FeS assembly protein SufB; Region: sufB; TIGR01980
1192196002532	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196002533	dimerization interface [polypeptide binding]; other site
1192196002534	putative DNA binding site [nucleotide binding]; other site
1192196002535	putative Zn2+ binding site [ion binding]; other site
1192196002536	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196002537	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1192196002538	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1192196002539	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1192196002540	Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322
1192196002541	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1192196002542	GIY-YIG motif/motif A; other site
1192196002543	active site
1192196002544	catalytic site [active]
1192196002545	putative DNA binding site [nucleotide binding]; other site
1192196002546	metal binding site [ion binding]; metal-binding site
1192196002547	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1192196002548	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1192196002549	putative active site [active]
1192196002550	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1192196002551	dimer interface [polypeptide binding]; other site
1192196002552	active site
1192196002553	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1192196002554	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1192196002555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196002556	dimer interface [polypeptide binding]; other site
1192196002557	conserved gate region; other site
1192196002558	putative PBP binding loops; other site
1192196002559	ABC-ATPase subunit interface; other site
1192196002560	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1192196002561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196002562	dimer interface [polypeptide binding]; other site
1192196002563	conserved gate region; other site
1192196002564	putative PBP binding loops; other site
1192196002565	ABC-ATPase subunit interface; other site
1192196002566	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1192196002567	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
1192196002568	substrate binding site [chemical binding]; other site
1192196002569	ATP binding site [chemical binding]; other site
1192196002570	DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402
1192196002571	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196002572	DNA-binding site [nucleotide binding]; DNA binding site
1192196002573	UTRA domain; Region: UTRA; pfam07702
1192196002574	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1192196002575	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1192196002576	Walker A/P-loop; other site
1192196002577	ATP binding site [chemical binding]; other site
1192196002578	Q-loop/lid; other site
1192196002579	ABC transporter signature motif; other site
1192196002580	Walker B; other site
1192196002581	D-loop; other site
1192196002582	H-loop/switch region; other site
1192196002583	TOBE domain; Region: TOBE_2; pfam08402
1192196002584	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
1192196002585	allantoate amidohydrolase; Reviewed; Region: PRK09290
1192196002586	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1192196002587	active site
1192196002588	metal binding site [ion binding]; metal-binding site
1192196002589	dimer interface [polypeptide binding]; other site
1192196002590	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1192196002591	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1192196002592	catalytic residue [active]
1192196002593	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1192196002594	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1192196002595	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1192196002596	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1192196002597	Ligand binding site; other site
1192196002598	metal-binding site
1192196002599	xanthine dehydrogenase C subunit; Region: pucC; TIGR03199
1192196002600	xanthine dehydrogenase D subunit; Region: pucD; TIGR03196
1192196002601	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1192196002602	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1192196002603	xanthine dehydrogenase E subunit; Region: pucE; TIGR03198
1192196002604	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1192196002605	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1192196002606	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1192196002607	active site
1192196002608	homotetramer interface [polypeptide binding]; other site
1192196002609	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
1192196002610	Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648
1192196002611	Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the...; Region: Uricase; cd00445
1192196002612	tetramer interface [polypeptide binding]; other site
1192196002613	active site
1192196002614	xanthine permease; Region: pbuX; TIGR03173
1192196002615	xanthine permease; Region: pbuX; TIGR03173
1192196002616	DRTGG domain; Region: DRTGG; pfam07085
1192196002617	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1192196002618	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1192196002619	allantoinase; Provisional; Region: PRK06189
1192196002620	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
1192196002621	active site
1192196002622	Uncharacterized conserved protein [Function unknown]; Region: COG1801
1192196002623	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1192196002624	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1192196002625	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1192196002626	active site
1192196002627	metal binding site [ion binding]; metal-binding site
1192196002628	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1192196002629	Uncharacterized conserved protein [Function unknown]; Region: COG3377
1192196002630	sporulation protein YunB; Region: spo_yunB; TIGR02832
1192196002631	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1192196002632	Peptidase family M23; Region: Peptidase_M23; pfam01551
1192196002633	lipoyl synthase; Provisional; Region: PRK05481
1192196002634	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196002635	FeS/SAM binding site; other site
1192196002636	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1192196002637	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
1192196002638	Uncharacterized conserved protein [Function unknown]; Region: COG2445
1192196002639	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
1192196002640	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196002641	active site
1192196002642	motif I; other site
1192196002643	motif II; other site
1192196002644	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196002645	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1192196002646	tetramer interfaces [polypeptide binding]; other site
1192196002647	binuclear metal-binding site [ion binding]; other site
1192196002648	spore coat protein YutH; Region: spore_yutH; TIGR02905
1192196002649	homoserine dehydrogenase; Provisional; Region: PRK06349
1192196002650	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1192196002651	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1192196002652	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1192196002653	threonine synthase; Reviewed; Region: PRK06721
1192196002654	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1192196002655	homodimer interface [polypeptide binding]; other site
1192196002656	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196002657	catalytic residue [active]
1192196002658	homoserine kinase; Region: thrB; TIGR00191
1192196002659	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1192196002660	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1192196002661	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1192196002662	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1192196002663	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1192196002664	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1192196002665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
1192196002666	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1192196002667	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196002668	Coenzyme A binding pocket [chemical binding]; other site
1192196002669	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
1192196002670	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1192196002671	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1192196002672	active site
1192196002673	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1192196002674	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1192196002675	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1192196002676	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1192196002677	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1192196002678	Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107
1192196002679	Putative membrane protein; Region: YuiB; pfam14068
1192196002680	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1192196002681	Divergent PAP2 family; Region: DUF212; pfam02681
1192196002682	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1192196002683	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1192196002684	interface (dimer of trimers) [polypeptide binding]; other site
1192196002685	Substrate-binding/catalytic site; other site
1192196002686	Zn-binding sites [ion binding]; other site
1192196002687	Predicted permease [General function prediction only]; Region: COG2056
1192196002688	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1192196002689	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1192196002690	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1192196002691	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
1192196002692	Moco binding site; other site
1192196002693	metal coordination site [ion binding]; other site
1192196002694	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1192196002695	Putative esterase; Region: Esterase; pfam00756
1192196002696	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
1192196002697	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
1192196002698	putative NAD(P) binding site [chemical binding]; other site
1192196002699	active site
1192196002700	isochorismate synthase DhbC; Validated; Region: PRK06923
1192196002701	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1192196002702	2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275
1192196002703	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1192196002704	acyl-activating enzyme (AAE) consensus motif; other site
1192196002705	active site
1192196002706	AMP binding site [chemical binding]; other site
1192196002707	substrate binding site [chemical binding]; other site
1192196002708	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
1192196002709	hydrophobic substrate binding pocket; other site
1192196002710	Isochorismatase family; Region: Isochorismatase; pfam00857
1192196002711	active site
1192196002712	conserved cis-peptide bond; other site
1192196002713	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1192196002714	Condensation domain; Region: Condensation; pfam00668
1192196002715	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1192196002716	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
1192196002717	acyl-activating enzyme (AAE) consensus motif; other site
1192196002718	AMP binding site [chemical binding]; other site
1192196002719	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196002720	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1192196002721	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1192196002722	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1192196002723	acyl-activating enzyme (AAE) consensus motif; other site
1192196002724	AMP binding site [chemical binding]; other site
1192196002725	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196002726	Uncharacterized conserved protein (DUF2278); Region: DUF2278; cl17857
1192196002727	Uncharacterized conserved protein (DUF2278); Region: DUF2278; cl17857
1192196002728	alanine dehydrogenase; Region: alaDH; TIGR00518
1192196002729	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1192196002730	hexamer interface [polypeptide binding]; other site
1192196002731	ligand binding site [chemical binding]; other site
1192196002732	putative active site [active]
1192196002733	NAD(P) binding site [chemical binding]; other site
1192196002734	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1192196002735	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1192196002736	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1192196002737	Uncharacterized small protein [Function unknown]; Region: COG5417
1192196002738	Ubiquitin homologues; Region: UBQ; smart00213
1192196002739	Predicted membrane protein [Function unknown]; Region: COG4499
1192196002740	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
1192196002741	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
1192196002742	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1192196002743	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1192196002744	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1192196002745	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1192196002746	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
1192196002747	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1192196002748	Predicted membrane protein [Function unknown]; Region: COG1511
1192196002749	exosortase F-associated protein; Region: flavo_near_exo; TIGR04127
1192196002750	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
1192196002751	short chain dehydrogenase; Provisional; Region: PRK06924
1192196002752	sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367
1192196002753	NADP binding site [chemical binding]; other site
1192196002754	homodimer interface [polypeptide binding]; other site
1192196002755	active site
1192196002756	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1192196002757	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1192196002758	Zn2+ binding site [ion binding]; other site
1192196002759	Mg2+ binding site [ion binding]; other site
1192196002760	Protein of unknown function (DUF2642); Region: DUF2642; pfam10842
1192196002761	Uncharacterized conserved small protein [Function unknown]; Region: COG5428
1192196002762	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1192196002763	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1192196002764	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1192196002765	YueH-like protein; Region: YueH; pfam14166
1192196002766	Uncharacterized conserved protein [Function unknown]; Region: COG5506
1192196002767	Isochorismatase family; Region: Isochorismatase; pfam00857
1192196002768	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1192196002769	catalytic triad [active]
1192196002770	conserved cis-peptide bond; other site
1192196002771	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1192196002772	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1192196002773	active site
1192196002774	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
1192196002775	EAL domain; Region: EAL; pfam00563
1192196002776	DegQ (SacQ) family; Region: DegQ; pfam08181
1192196002777	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1192196002778	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1192196002779	substrate binding pocket [chemical binding]; other site
1192196002780	substrate-Mg2+ binding site; other site
1192196002781	aspartate-rich region 1; other site
1192196002782	Bacillus competence pheromone ComX; Region: ComX; pfam05952
1192196002783	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1192196002784	Histidine kinase; Region: HisKA_3; pfam07730
1192196002785	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196002786	ATP binding site [chemical binding]; other site
1192196002787	Mg2+ binding site [ion binding]; other site
1192196002788	G-X-G motif; other site
1192196002789	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1192196002790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196002791	active site
1192196002792	phosphorylation site [posttranslational modification]
1192196002793	intermolecular recognition site; other site
1192196002794	dimerization interface [polypeptide binding]; other site
1192196002795	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1192196002796	DNA binding residues [nucleotide binding]
1192196002797	dimerization interface [polypeptide binding]; other site
1192196002798	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1192196002799	CoenzymeA binding site [chemical binding]; other site
1192196002800	subunit interaction site [polypeptide binding]; other site
1192196002801	PHB binding site; other site
1192196002802	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
1192196002803	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
1192196002804	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
1192196002805	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
1192196002806	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1192196002807	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
1192196002808	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
1192196002809	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
1192196002810	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1192196002811	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1192196002812	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
1192196002813	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1192196002814	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1192196002815	TM-ABC transporter signature motif; other site
1192196002816	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1192196002817	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1192196002818	TM-ABC transporter signature motif; other site
1192196002819	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1192196002820	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1192196002821	Walker A/P-loop; other site
1192196002822	ATP binding site [chemical binding]; other site
1192196002823	Q-loop/lid; other site
1192196002824	ABC transporter signature motif; other site
1192196002825	Walker B; other site
1192196002826	D-loop; other site
1192196002827	H-loop/switch region; other site
1192196002828	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1192196002829	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1192196002830	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1192196002831	ligand binding site [chemical binding]; other site
1192196002832	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1192196002833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196002834	active site
1192196002835	phosphorylation site [posttranslational modification]
1192196002836	intermolecular recognition site; other site
1192196002837	dimerization interface [polypeptide binding]; other site
1192196002838	sensory histidine kinase DcuS; Provisional; Region: PRK11086
1192196002839	PAS domain; Region: PAS; smart00091
1192196002840	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196002841	ATP binding site [chemical binding]; other site
1192196002842	G-X-G motif; other site
1192196002843	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
1192196002844	Transglycosylase; Region: Transgly; pfam00912
1192196002845	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1192196002846	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1192196002847	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196002848	drug efflux system protein MdtG; Provisional; Region: PRK09874
1192196002849	putative substrate translocation pore; other site
1192196002850	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
1192196002851	active site
1192196002852	catalytic site [active]
1192196002853	substrate binding site [chemical binding]; other site
1192196002854	Kinase associated protein B; Region: KapB; pfam08810
1192196002855	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1192196002856	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196002857	dimer interface [polypeptide binding]; other site
1192196002858	phosphorylation site [posttranslational modification]
1192196002859	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196002860	ATP binding site [chemical binding]; other site
1192196002861	Mg2+ binding site [ion binding]; other site
1192196002862	G-X-G motif; other site
1192196002863	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1192196002864	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196002865	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196002866	homodimer interface [polypeptide binding]; other site
1192196002867	catalytic residue [active]
1192196002868	Domain of unknown function (DUF1871); Region: DUF1871; pfam08958
1192196002869	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1192196002870	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1192196002871	nucleophilic elbow; other site
1192196002872	catalytic triad; other site
1192196002873	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1192196002874	AsnC family; Region: AsnC_trans_reg; pfam01037
1192196002875	hypothetical protein; Validated; Region: PRK07682
1192196002876	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196002877	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196002878	homodimer interface [polypeptide binding]; other site
1192196002879	catalytic residue [active]
1192196002880	general stress protein 13; Validated; Region: PRK08059
1192196002881	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1192196002882	RNA binding site [nucleotide binding]; other site
1192196002883	Uncharacterized conserved protein [Function unknown]; Region: COG2155
1192196002884	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1192196002885	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1192196002886	dimer interface [polypeptide binding]; other site
1192196002887	active site
1192196002888	metal binding site [ion binding]; metal-binding site
1192196002889	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1192196002890	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1192196002891	dimer interface [polypeptide binding]; other site
1192196002892	active site
1192196002893	metal binding site [ion binding]; metal-binding site
1192196002894	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1192196002895	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1192196002896	active site
1192196002897	dimer interface [polypeptide binding]; other site
1192196002898	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1192196002899	dimer interface [polypeptide binding]; other site
1192196002900	active site
1192196002901	YugN-like family; Region: YugN; pfam08868
1192196002902	Membrane-integrating protein Mistic; Region: Mistic; pfam11458
1192196002903	Ion channel; Region: Ion_trans_2; pfam07885
1192196002904	TrkA-N domain; Region: TrkA_N; pfam02254
1192196002905	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
1192196002906	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1192196002907	Domain of unknown function DUF21; Region: DUF21; pfam01595
1192196002908	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1192196002909	Transporter associated domain; Region: CorC_HlyC; smart01091
1192196002910	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1192196002911	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1192196002912	Ca binding site [ion binding]; other site
1192196002913	active site
1192196002914	catalytic site [active]
1192196002915	secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ
1192196002916	transglutaminase; Provisional; Region: tgl; PRK03187
1192196002917	Homologues of the ligand binding domain of Tar; Region: TarH; smart00319
1192196002918	Cache domain; Region: Cache_1; pfam02743
1192196002919	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196002920	dimerization interface [polypeptide binding]; other site
1192196002921	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1192196002922	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1192196002923	dimer interface [polypeptide binding]; other site
1192196002924	putative CheW interface [polypeptide binding]; other site
1192196002925	Tar ligand binding domain homologue; Region: TarH; pfam02203
1192196002926	Cache domain; Region: Cache_1; pfam02743
1192196002927	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1192196002928	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196002929	dimerization interface [polypeptide binding]; other site
1192196002930	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1192196002931	dimer interface [polypeptide binding]; other site
1192196002932	putative CheW interface [polypeptide binding]; other site
1192196002933	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1192196002934	Cache domain; Region: Cache_1; pfam02743
1192196002935	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196002936	dimerization interface [polypeptide binding]; other site
1192196002937	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1192196002938	dimer interface [polypeptide binding]; other site
1192196002939	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1192196002940	putative CheW interface [polypeptide binding]; other site
1192196002941	Homologues of the ligand binding domain of Tar; Region: TarH; smart00319
1192196002942	Cache domain; Region: Cache_1; pfam02743
1192196002943	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196002944	dimerization interface [polypeptide binding]; other site
1192196002945	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1192196002946	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1192196002947	dimer interface [polypeptide binding]; other site
1192196002948	putative CheW interface [polypeptide binding]; other site
1192196002949	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1192196002950	short chain dehydrogenase; Validated; Region: PRK08324
1192196002951	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
1192196002952	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
1192196002953	putative NAD(P) binding site [chemical binding]; other site
1192196002954	active site
1192196002955	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1192196002956	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1192196002957	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1192196002958	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
1192196002959	N- and C-terminal domain interface [polypeptide binding]; other site
1192196002960	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
1192196002961	active site
1192196002962	putative catalytic site [active]
1192196002963	metal binding site [ion binding]; metal-binding site
1192196002964	ATP binding site [chemical binding]; other site
1192196002965	carbohydrate binding site [chemical binding]; other site
1192196002966	Domain of unknown function (DUF718); Region: DUF718; cl01281
1192196002967	L-rhamnose isomerase (RhaA); Region: RhaA; pfam06134
1192196002968	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
1192196002969	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1192196002970	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1192196002971	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1192196002972	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1192196002973	undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753
1192196002974	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
1192196002975	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196002976	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196002977	putative substrate translocation pore; other site
1192196002978	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1192196002979	SH3-like domain; Region: SH3_8; pfam13457
1192196002980	Predicted membrane protein [Function unknown]; Region: COG4682
1192196002981	yiaA/B two helix domain; Region: YiaAB; pfam05360
1192196002982	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1192196002983	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1192196002984	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1192196002985	TrkA-N domain; Region: TrkA_N; pfam02254
1192196002986	TrkA-C domain; Region: TrkA_C; pfam02080
1192196002987	Predicted transcriptional regulators [Transcription]; Region: COG1510
1192196002988	MarR family; Region: MarR_2; pfam12802
1192196002989	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1192196002990	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
1192196002991	tetramerization interface [polypeptide binding]; other site
1192196002992	NAD(P) binding site [chemical binding]; other site
1192196002993	catalytic residues [active]
1192196002994	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1192196002995	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1192196002996	active site
1192196002997	NAD binding site [chemical binding]; other site
1192196002998	metal binding site [ion binding]; metal-binding site
1192196002999	MOSC domain; Region: MOSC; pfam03473
1192196003000	DinB superfamily; Region: DinB_2; pfam12867
1192196003001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
1192196003002	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1192196003003	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1192196003004	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196003005	Coenzyme A binding pocket [chemical binding]; other site
1192196003006	Predicted membrane protein [Function unknown]; Region: COG3859
1192196003007	alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515
1192196003008	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1192196003009	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1192196003010	active site
1192196003011	catalytic site [active]
1192196003012	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1192196003013	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
1192196003014	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1192196003015	ligand binding site; other site
1192196003016	oligomer interface; other site
1192196003017	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1192196003018	dimer interface [polypeptide binding]; other site
1192196003019	N-terminal domain interface [polypeptide binding]; other site
1192196003020	sulfate 1 binding site; other site
1192196003021	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
1192196003022	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1192196003023	ligand binding site; other site
1192196003024	oligomer interface; other site
1192196003025	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1192196003026	dimer interface [polypeptide binding]; other site
1192196003027	N-terminal domain interface [polypeptide binding]; other site
1192196003028	sulfate 1 binding site; other site
1192196003029	glycogen synthase; Provisional; Region: glgA; PRK00654
1192196003030	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1192196003031	ADP-binding pocket [chemical binding]; other site
1192196003032	homodimer interface [polypeptide binding]; other site
1192196003033	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1192196003034	homodimer interface [polypeptide binding]; other site
1192196003035	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1192196003036	active site pocket [active]
1192196003037	TspO/MBR family; Region: TspO_MBR; cl01379
1192196003038	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
1192196003039	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
1192196003040	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1192196003041	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1192196003042	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
1192196003043	spore coat protein YutH; Region: spore_yutH; TIGR02905
1192196003044	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1192196003045	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1192196003046	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1192196003047	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1192196003048	NAD(P) binding site [chemical binding]; other site
1192196003049	active site
1192196003050	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1192196003051	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1192196003052	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1192196003053	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1192196003054	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1192196003055	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1192196003056	active site
1192196003057	tetramer interface; other site
1192196003058	regulatory protein, yteA family; Region: bacill_yteA; TIGR02890
1192196003059	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1192196003060	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1192196003061	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
1192196003062	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1192196003063	dimer interface [polypeptide binding]; other site
1192196003064	tetramer interface [polypeptide binding]; other site
1192196003065	PYR/PP interface [polypeptide binding]; other site
1192196003066	TPP binding site [chemical binding]; other site
1192196003067	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1192196003068	TPP-binding site; other site
1192196003069	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1192196003070	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1192196003071	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1192196003072	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1192196003073	substrate binding site [chemical binding]; other site
1192196003074	oxyanion hole (OAH) forming residues; other site
1192196003075	trimer interface [polypeptide binding]; other site
1192196003076	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
1192196003077	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1192196003078	acyl-activating enzyme (AAE) consensus motif; other site
1192196003079	putative AMP binding site [chemical binding]; other site
1192196003080	putative active site [active]
1192196003081	putative CoA binding site [chemical binding]; other site
1192196003082	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
1192196003083	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1192196003084	active site
1192196003085	octamer interface [polypeptide binding]; other site
1192196003086	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1192196003087	Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species.  The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016
1192196003088	metal binding site [ion binding]; metal-binding site
1192196003089	intersubunit interface [polypeptide binding]; other site
1192196003090	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1192196003091	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1192196003092	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1192196003093	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196003094	ABC-ATPase subunit  interface; other site
1192196003095	dimer interface [polypeptide binding]; other site
1192196003096	putative PBP binding regions; other site
1192196003097	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1192196003098	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1192196003099	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196003100	ABC-ATPase subunit  interface; other site
1192196003101	dimer interface [polypeptide binding]; other site
1192196003102	putative PBP binding regions; other site
1192196003103	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1192196003104	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1192196003105	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1192196003106	active site clefts [active]
1192196003107	zinc binding site [ion binding]; other site
1192196003108	dimer interface [polypeptide binding]; other site
1192196003109	Haemolytic domain; Region: Haemolytic; pfam01809
1192196003110	S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664
1192196003111	YtkA-like; Region: YtkA; pfam13115
1192196003112	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1192196003113	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1192196003114	dimerization interface [polypeptide binding]; other site
1192196003115	DPS ferroxidase diiron center [ion binding]; other site
1192196003116	ion pore; other site
1192196003117	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
1192196003118	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
1192196003119	nudix motif; other site
1192196003120	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1192196003121	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196003122	dimer interface [polypeptide binding]; other site
1192196003123	conserved gate region; other site
1192196003124	putative PBP binding loops; other site
1192196003125	ABC-ATPase subunit interface; other site
1192196003126	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1192196003127	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1192196003128	Walker A/P-loop; other site
1192196003129	ATP binding site [chemical binding]; other site
1192196003130	Q-loop/lid; other site
1192196003131	ABC transporter signature motif; other site
1192196003132	Walker B; other site
1192196003133	D-loop; other site
1192196003134	H-loop/switch region; other site
1192196003135	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1192196003136	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1192196003137	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1192196003138	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1192196003139	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1192196003140	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
1192196003141	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1192196003142	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1192196003143	active site
1192196003144	substrate-binding site [chemical binding]; other site
1192196003145	metal-binding site [ion binding]
1192196003146	ATP binding site [chemical binding]; other site
1192196003147	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1192196003148	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1192196003149	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1192196003150	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1192196003151	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1192196003152	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1192196003153	active site
1192196003154	dimer interface [polypeptide binding]; other site
1192196003155	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1192196003156	Ligand Binding Site [chemical binding]; other site
1192196003157	Molecular Tunnel; other site
1192196003158	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1192196003159	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1192196003160	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1192196003161	trimer interface [polypeptide binding]; other site
1192196003162	putative metal binding site [ion binding]; other site
1192196003163	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1192196003164	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1192196003165	PGAP1-like protein; Region: PGAP1; pfam07819
1192196003166	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
1192196003167	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
1192196003168	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1192196003169	Protein of unknown function (DUF2524); Region: DUF2524; pfam10732
1192196003170	Predicted transcriptional regulators [Transcription]; Region: COG1725
1192196003171	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196003172	DNA-binding site [nucleotide binding]; DNA binding site
1192196003173	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1192196003174	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1192196003175	Walker A/P-loop; other site
1192196003176	ATP binding site [chemical binding]; other site
1192196003177	Q-loop/lid; other site
1192196003178	ABC transporter signature motif; other site
1192196003179	Walker B; other site
1192196003180	D-loop; other site
1192196003181	H-loop/switch region; other site
1192196003182	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1192196003183	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1192196003184	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1192196003185	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1192196003186	Walker A/P-loop; other site
1192196003187	ATP binding site [chemical binding]; other site
1192196003188	Q-loop/lid; other site
1192196003189	ABC transporter signature motif; other site
1192196003190	Walker B; other site
1192196003191	D-loop; other site
1192196003192	H-loop/switch region; other site
1192196003193	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1192196003194	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1192196003195	FtsX-like permease family; Region: FtsX; pfam02687
1192196003196	Response regulator receiver domain; Region: Response_reg; pfam00072
1192196003197	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196003198	active site
1192196003199	phosphorylation site [posttranslational modification]
1192196003200	intermolecular recognition site; other site
1192196003201	dimerization interface [polypeptide binding]; other site
1192196003202	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1192196003203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196003204	ATP binding site [chemical binding]; other site
1192196003205	Mg2+ binding site [ion binding]; other site
1192196003206	G-X-G motif; other site
1192196003207	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1192196003208	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1192196003209	Walker A/P-loop; other site
1192196003210	ATP binding site [chemical binding]; other site
1192196003211	Q-loop/lid; other site
1192196003212	ABC transporter signature motif; other site
1192196003213	Walker B; other site
1192196003214	D-loop; other site
1192196003215	H-loop/switch region; other site
1192196003216	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1192196003217	FtsX-like permease family; Region: FtsX; pfam02687
1192196003218	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1192196003219	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1192196003220	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196003221	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196003222	putative substrate translocation pore; other site
1192196003223	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196003224	PAS domain; Region: PAS_9; pfam13426
1192196003225	putative active site [active]
1192196003226	heme pocket [chemical binding]; other site
1192196003227	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1192196003228	Protein of unknown function (DUF4257); Region: DUF4257; pfam14074
1192196003229	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1192196003230	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1192196003231	HIGH motif; other site
1192196003232	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1192196003233	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1192196003234	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1192196003235	active site
1192196003236	KMSKS motif; other site
1192196003237	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1192196003238	tRNA binding surface [nucleotide binding]; other site
1192196003239	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1192196003240	active site residue [active]
1192196003241	alpha-galactosidase; Provisional; Region: PRK15076
1192196003242	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
1192196003243	NAD binding site [chemical binding]; other site
1192196003244	sugar binding site [chemical binding]; other site
1192196003245	divalent metal binding site [ion binding]; other site
1192196003246	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1192196003247	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1192196003248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196003249	dimer interface [polypeptide binding]; other site
1192196003250	conserved gate region; other site
1192196003251	putative PBP binding loops; other site
1192196003252	ABC-ATPase subunit interface; other site
1192196003253	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1192196003254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196003255	dimer interface [polypeptide binding]; other site
1192196003256	conserved gate region; other site
1192196003257	putative PBP binding loops; other site
1192196003258	ABC-ATPase subunit interface; other site
1192196003259	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1192196003260	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1192196003261	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1192196003262	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1192196003263	DNA binding site [nucleotide binding]
1192196003264	domain linker motif; other site
1192196003265	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1192196003266	putative ligand binding site [chemical binding]; other site
1192196003267	putative dimerization interface [polypeptide binding]; other site
1192196003268	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1192196003269	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1192196003270	Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
1192196003271	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916
1192196003272	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1192196003273	inhibitor-cofactor binding pocket; inhibition site
1192196003274	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196003275	catalytic residue [active]
1192196003276	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1192196003277	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1192196003278	substrate-cofactor binding pocket; other site
1192196003279	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196003280	catalytic residue [active]
1192196003281	AAA domain; Region: AAA_26; pfam13500
1192196003282	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1192196003283	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
1192196003284	biotin synthase; Validated; Region: PRK06256
1192196003285	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196003286	FeS/SAM binding site; other site
1192196003287	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1192196003288	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1192196003289	Cytochrome P450; Region: p450; cl12078
1192196003290	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1192196003291	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1192196003292	active site
1192196003293	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1192196003294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196003295	dimer interface [polypeptide binding]; other site
1192196003296	conserved gate region; other site
1192196003297	putative PBP binding loops; other site
1192196003298	ABC-ATPase subunit interface; other site
1192196003299	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1192196003300	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1192196003301	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1192196003302	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1192196003303	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1192196003304	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196003305	dimer interface [polypeptide binding]; other site
1192196003306	conserved gate region; other site
1192196003307	ABC-ATPase subunit interface; other site
1192196003308	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1192196003309	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1192196003310	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1192196003311	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1192196003312	Predicted integral membrane protein [Function unknown]; Region: COG5578
1192196003313	Protein of unknown function (DUF2758); Region: DUF2758; pfam10957
1192196003314	BCCT family transporter; Region: BCCT; pfam02028
1192196003315	Predicted flavoproteins [General function prediction only]; Region: COG2081
1192196003316	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1192196003317	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1192196003318	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1192196003319	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1192196003320	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1192196003321	RNA binding surface [nucleotide binding]; other site
1192196003322	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1192196003323	pseudouridine synthase; Region: TIGR00093
1192196003324	active site
1192196003325	uracil binding [chemical binding]; other site
1192196003326	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1192196003327	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1192196003328	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1192196003329	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1192196003330	Walker A/P-loop; other site
1192196003331	ATP binding site [chemical binding]; other site
1192196003332	Q-loop/lid; other site
1192196003333	ABC transporter signature motif; other site
1192196003334	Walker B; other site
1192196003335	D-loop; other site
1192196003336	H-loop/switch region; other site
1192196003337	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
1192196003338	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1192196003339	dipeptidase PepV; Reviewed; Region: PRK07318
1192196003340	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1192196003341	active site
1192196003342	metal binding site [ion binding]; metal-binding site
1192196003343	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1192196003344	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1192196003345	dimer interface [polypeptide binding]; other site
1192196003346	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196003347	catalytic residue [active]
1192196003348	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
1192196003349	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1192196003350	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1192196003351	lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147
1192196003352	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1192196003353	pullulanase, type I; Region: pulA_typeI; TIGR02104
1192196003354	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1192196003355	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1192196003356	Ca binding site [ion binding]; other site
1192196003357	active site
1192196003358	catalytic site [active]
1192196003359	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1192196003360	active site
1192196003361	ATP binding site [chemical binding]; other site
1192196003362	Phosphotransferase enzyme family; Region: APH; pfam01636
1192196003363	substrate binding site [chemical binding]; other site
1192196003364	YtzH-like protein; Region: YtzH; pfam14165
1192196003365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196003366	S-adenosylmethionine binding site [chemical binding]; other site
1192196003367	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1192196003368	malate dehydrogenase; Provisional; Region: PRK13529
1192196003369	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1192196003370	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1192196003371	NAD(P) binding site [chemical binding]; other site
1192196003372	Predicted small secreted protein [Function unknown]; Region: COG5584
1192196003373	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1192196003374	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1192196003375	oligomer interface [polypeptide binding]; other site
1192196003376	active site
1192196003377	metal binding site [ion binding]; metal-binding site
1192196003378	YtoQ family protein; Region: YtoQ_fam; TIGR03646
1192196003379	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1192196003380	catalytic residues [active]
1192196003381	hypothetical protein; Provisional; Region: PRK13668
1192196003382	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1192196003383	putative tRNA-binding site [nucleotide binding]; other site
1192196003384	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1192196003385	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1192196003386	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1192196003387	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1192196003388	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1192196003389	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1192196003390	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1192196003391	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1192196003392	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
1192196003393	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1192196003394	catalytic residues [active]
1192196003395	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
1192196003396	chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801
1192196003397	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1192196003398	catabolite control protein A; Region: ccpA; TIGR01481
1192196003399	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1192196003400	DNA binding site [nucleotide binding]
1192196003401	domain linker motif; other site
1192196003402	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1192196003403	dimerization interface [polypeptide binding]; other site
1192196003404	effector binding site; other site
1192196003405	flagellar motor protein MotP; Reviewed; Region: PRK06926
1192196003406	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1192196003407	flagellar motor protein MotS; Reviewed; Region: PRK06925
1192196003408	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1192196003409	ligand binding site [chemical binding]; other site
1192196003410	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1192196003411	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1192196003412	active site
1192196003413	Zn binding site [ion binding]; other site
1192196003414	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196003415	Coenzyme A binding pocket [chemical binding]; other site
1192196003416	acetyl-CoA synthetase; Provisional; Region: PRK04319
1192196003417	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1192196003418	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
1192196003419	active site
1192196003420	acyl-activating enzyme (AAE) consensus motif; other site
1192196003421	putative CoA binding site [chemical binding]; other site
1192196003422	AMP binding site [chemical binding]; other site
1192196003423	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1192196003424	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
1192196003425	active site
1192196003426	HIGH motif; other site
1192196003427	dimer interface [polypeptide binding]; other site
1192196003428	KMSKS motif; other site
1192196003429	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1192196003430	RNA binding surface [nucleotide binding]; other site
1192196003431	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1192196003432	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1192196003433	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1192196003434	RNA binding surface [nucleotide binding]; other site
1192196003435	GAF domain; Region: GAF; cl17456
1192196003436	GAF domain; Region: GAF_3; pfam13492
1192196003437	GAF domain; Region: GAF_2; pfam13185
1192196003438	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1192196003439	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1192196003440	metal binding site [ion binding]; metal-binding site
1192196003441	active site
1192196003442	I-site; other site
1192196003443	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1192196003444	GAF domain; Region: GAF_2; pfam13185
1192196003445	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196003446	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196003447	histidinol-phosphatase; Reviewed; Region: PRK08123
1192196003448	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
1192196003449	active site
1192196003450	dimer interface [polypeptide binding]; other site
1192196003451	TMPIT-like protein; Region: TMPIT; pfam07851
1192196003452	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1192196003453	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1192196003454	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1192196003455	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1192196003456	catalytic residue [active]
1192196003457	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1192196003458	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1192196003459	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1192196003460	Ligand Binding Site [chemical binding]; other site
1192196003461	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1192196003462	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1192196003463	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
1192196003464	active site
1192196003465	acyl-activating enzyme (AAE) consensus motif; other site
1192196003466	putative CoA binding site [chemical binding]; other site
1192196003467	AMP binding site [chemical binding]; other site
1192196003468	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1192196003469	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1192196003470	active site
1192196003471	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
1192196003472	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1192196003473	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1192196003474	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1192196003475	tandem repeat interface [polypeptide binding]; other site
1192196003476	oligomer interface [polypeptide binding]; other site
1192196003477	active site residues [active]
1192196003478	Predicted membrane protein/domain [Function unknown]; Region: COG1714
1192196003479	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
1192196003480	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
1192196003481	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1192196003482	dimer interface [polypeptide binding]; other site
1192196003483	catalytic triad [active]
1192196003484	peroxidatic and resolving cysteines [active]
1192196003485	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1192196003486	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196003487	S-adenosylmethionine binding site [chemical binding]; other site
1192196003488	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1192196003489	propionate/acetate kinase; Provisional; Region: PRK12379
1192196003490	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1192196003491	MPT binding site; other site
1192196003492	trimer interface [polypeptide binding]; other site
1192196003493	argininosuccinate synthase; Provisional; Region: PRK13820
1192196003494	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1192196003495	ANP binding site [chemical binding]; other site
1192196003496	Substrate Binding Site II [chemical binding]; other site
1192196003497	Substrate Binding Site I [chemical binding]; other site
1192196003498	argininosuccinate lyase; Provisional; Region: PRK00855
1192196003499	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1192196003500	active sites [active]
1192196003501	tetramer interface [polypeptide binding]; other site
1192196003502	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1192196003503	classical (c) SDRs; Region: SDR_c; cd05233
1192196003504	NAD(P) binding site [chemical binding]; other site
1192196003505	active site
1192196003506	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1192196003507	metal-dependent hydrolase; Provisional; Region: PRK00685
1192196003508	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196003509	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196003510	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1192196003511	dimerization interface [polypeptide binding]; other site
1192196003512	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1192196003513	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196003514	Coenzyme A binding pocket [chemical binding]; other site
1192196003515	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1192196003516	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1192196003517	substrate binding pocket [chemical binding]; other site
1192196003518	membrane-bound complex binding site; other site
1192196003519	hinge residues; other site
1192196003520	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1192196003521	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1192196003522	substrate binding pocket [chemical binding]; other site
1192196003523	membrane-bound complex binding site; other site
1192196003524	hinge residues; other site
1192196003525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196003526	dimer interface [polypeptide binding]; other site
1192196003527	conserved gate region; other site
1192196003528	putative PBP binding loops; other site
1192196003529	ABC-ATPase subunit interface; other site
1192196003530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196003531	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1192196003532	dimer interface [polypeptide binding]; other site
1192196003533	conserved gate region; other site
1192196003534	putative PBP binding loops; other site
1192196003535	ABC-ATPase subunit interface; other site
1192196003536	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1192196003537	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1192196003538	Walker A/P-loop; other site
1192196003539	ATP binding site [chemical binding]; other site
1192196003540	Q-loop/lid; other site
1192196003541	ABC transporter signature motif; other site
1192196003542	Walker B; other site
1192196003543	D-loop; other site
1192196003544	H-loop/switch region; other site
1192196003545	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1192196003546	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1192196003547	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1192196003548	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1192196003549	catalytic residues [active]
1192196003550	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1192196003551	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1192196003552	active site
1192196003553	non-prolyl cis peptide bond; other site
1192196003554	Riboflavin kinase; Region: Flavokinase; pfam01687
1192196003555	Riboflavin kinase; Region: Flavokinase; smart00904
1192196003556	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1192196003557	amidohydrolase; Region: amidohydrolases; TIGR01891
1192196003558	metal binding site [ion binding]; metal-binding site
1192196003559	dimer interface [polypeptide binding]; other site
1192196003560	Predicted permeases [General function prediction only]; Region: COG0730
1192196003561	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1192196003562	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196003563	DNA-binding site [nucleotide binding]; DNA binding site
1192196003564	DRTGG domain; Region: DRTGG; pfam07085
1192196003565	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1192196003566	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1192196003567	active site 2 [active]
1192196003568	active site 1 [active]
1192196003569	YtpI-like protein; Region: YtpI; pfam14007
1192196003570	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1192196003571	DHH family; Region: DHH; pfam01368
1192196003572	DHHA1 domain; Region: DHHA1; pfam02272
1192196003573	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
1192196003574	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1192196003575	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1192196003576	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1192196003577	generic binding surface I; other site
1192196003578	generic binding surface II; other site
1192196003579	acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515
1192196003580	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1192196003581	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1192196003582	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1192196003583	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1192196003584	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1192196003585	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1192196003586	active site
1192196003587	ADP/pyrophosphate binding site [chemical binding]; other site
1192196003588	dimerization interface [polypeptide binding]; other site
1192196003589	allosteric effector site; other site
1192196003590	fructose-1,6-bisphosphate binding site; other site
1192196003591	pyruvate kinase; Provisional; Region: PRK06354
1192196003592	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
1192196003593	domain interfaces; other site
1192196003594	active site
1192196003595	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1192196003596	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
1192196003597	sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872
1192196003598	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1192196003599	Predicted membrane protein [Function unknown]; Region: COG2707
1192196003600	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1192196003601	dimer interface [polypeptide binding]; other site
1192196003602	Citrate synthase; Region: Citrate_synt; pfam00285
1192196003603	active site
1192196003604	citrylCoA binding site [chemical binding]; other site
1192196003605	oxalacetate/citrate binding site [chemical binding]; other site
1192196003606	coenzyme A binding site [chemical binding]; other site
1192196003607	catalytic triad [active]
1192196003608	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1192196003609	isocitrate dehydrogenase; Validated; Region: PRK07362
1192196003610	malate dehydrogenase; Reviewed; Region: PRK06223
1192196003611	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
1192196003612	NAD(P) binding site [chemical binding]; other site
1192196003613	dimer interface [polypeptide binding]; other site
1192196003614	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1192196003615	substrate binding site [chemical binding]; other site
1192196003616	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1192196003617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196003618	active site
1192196003619	phosphorylation site [posttranslational modification]
1192196003620	intermolecular recognition site; other site
1192196003621	dimerization interface [polypeptide binding]; other site
1192196003622	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1192196003623	DNA binding site [nucleotide binding]
1192196003624	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1192196003625	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196003626	putative active site [active]
1192196003627	heme pocket [chemical binding]; other site
1192196003628	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196003629	dimer interface [polypeptide binding]; other site
1192196003630	phosphorylation site [posttranslational modification]
1192196003631	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196003632	ATP binding site [chemical binding]; other site
1192196003633	Mg2+ binding site [ion binding]; other site
1192196003634	G-X-G motif; other site
1192196003635	DNA polymerase I; Provisional; Region: PRK05755
1192196003636	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1192196003637	active site
1192196003638	metal binding site 1 [ion binding]; metal-binding site
1192196003639	putative 5' ssDNA interaction site; other site
1192196003640	metal binding site 3; metal-binding site
1192196003641	metal binding site 2 [ion binding]; metal-binding site
1192196003642	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1192196003643	putative DNA binding site [nucleotide binding]; other site
1192196003644	putative metal binding site [ion binding]; other site
1192196003645	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1192196003646	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1192196003647	active site
1192196003648	DNA binding site [nucleotide binding]
1192196003649	catalytic site [active]
1192196003650	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1192196003651	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1192196003652	DNA binding site [nucleotide binding]
1192196003653	catalytic residue [active]
1192196003654	H2TH interface [polypeptide binding]; other site
1192196003655	putative catalytic residues [active]
1192196003656	turnover-facilitating residue; other site
1192196003657	intercalation triad [nucleotide binding]; other site
1192196003658	8OG recognition residue [nucleotide binding]; other site
1192196003659	putative reading head residues; other site
1192196003660	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1192196003661	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1192196003662	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
1192196003663	Domain of unknown function DUF; Region: DUF204; pfam02659
1192196003664	dephospho-CoA kinase; Region: TIGR00152
1192196003665	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1192196003666	ATP-binding [chemical binding]; other site
1192196003667	CoA-binding site [chemical binding]; other site
1192196003668	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1192196003669	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1192196003670	active site
1192196003671	catalytic tetrad [active]
1192196003672	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1192196003673	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196003674	putative substrate translocation pore; other site
1192196003675	Predicted transcriptional regulators [Transcription]; Region: COG1733
1192196003676	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1192196003677	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1192196003678	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1192196003679	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
1192196003680	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1192196003681	ATP cone domain; Region: ATP-cone; pfam03477
1192196003682	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1192196003683	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1192196003684	primosomal protein DnaI; Reviewed; Region: PRK08939
1192196003685	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1192196003686	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196003687	Walker A motif; other site
1192196003688	ATP binding site [chemical binding]; other site
1192196003689	Walker B motif; other site
1192196003690	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1192196003691	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1192196003692	putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834
1192196003693	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1192196003694	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1192196003695	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1192196003696	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1192196003697	active site
1192196003698	dimer interface [polypeptide binding]; other site
1192196003699	motif 1; other site
1192196003700	motif 2; other site
1192196003701	motif 3; other site
1192196003702	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1192196003703	anticodon binding site; other site
1192196003704	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1192196003705	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196003706	motif II; other site
1192196003707	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1192196003708	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1192196003709	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1192196003710	Histidine kinase; Region: His_kinase; pfam06580
1192196003711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196003712	ATP binding site [chemical binding]; other site
1192196003713	Mg2+ binding site [ion binding]; other site
1192196003714	G-X-G motif; other site
1192196003715	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1192196003716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196003717	active site
1192196003718	phosphorylation site [posttranslational modification]
1192196003719	intermolecular recognition site; other site
1192196003720	dimerization interface [polypeptide binding]; other site
1192196003721	LytTr DNA-binding domain; Region: LytTR; pfam04397
1192196003722	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
1192196003723	antiholin-like protein LrgB; Provisional; Region: PRK04288
1192196003724	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1192196003725	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1192196003726	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1192196003727	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1192196003728	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1192196003729	23S rRNA binding site [nucleotide binding]; other site
1192196003730	L21 binding site [polypeptide binding]; other site
1192196003731	L13 binding site [polypeptide binding]; other site
1192196003732	Predicted membrane protein [Function unknown]; Region: COG3326
1192196003733	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1192196003734	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1192196003735	oligomer interface [polypeptide binding]; other site
1192196003736	active site
1192196003737	metal binding site [ion binding]; metal-binding site
1192196003738	Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988
1192196003739	substrate binding site [chemical binding]; other site
1192196003740	active site
1192196003741	L-arabinose isomerase; Provisional; Region: PRK02929
1192196003742	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
1192196003743	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
1192196003744	trimer interface [polypeptide binding]; other site
1192196003745	putative substrate binding site [chemical binding]; other site
1192196003746	putative metal binding site [ion binding]; other site
1192196003747	L-ribulokinase; Region: L-ribulokinase; TIGR01234
1192196003748	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1192196003749	N- and C-terminal domain interface [polypeptide binding]; other site
1192196003750	active site
1192196003751	MgATP binding site [chemical binding]; other site
1192196003752	catalytic site [active]
1192196003753	metal binding site [ion binding]; metal-binding site
1192196003754	carbohydrate binding site [chemical binding]; other site
1192196003755	homodimer interface [polypeptide binding]; other site
1192196003756	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1192196003757	L-ribulose-5-phosphate 4-epimerase; Region: araD; TIGR00760
1192196003758	intersubunit interface [polypeptide binding]; other site
1192196003759	active site
1192196003760	Zn2+ binding site [ion binding]; other site
1192196003761	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1192196003762	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196003763	active site
1192196003764	motif I; other site
1192196003765	motif II; other site
1192196003766	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196003767	motif II; other site
1192196003768	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1192196003769	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
1192196003770	active site
1192196003771	metal binding site [ion binding]; metal-binding site
1192196003772	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1192196003773	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1192196003774	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1192196003775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196003776	dimer interface [polypeptide binding]; other site
1192196003777	conserved gate region; other site
1192196003778	putative PBP binding loops; other site
1192196003779	ABC-ATPase subunit interface; other site
1192196003780	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1192196003781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196003782	putative PBP binding loops; other site
1192196003783	dimer interface [polypeptide binding]; other site
1192196003784	ABC-ATPase subunit interface; other site
1192196003785	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1192196003786	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1192196003787	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1192196003788	Carbon starvation protein CstA; Region: CstA; pfam02554
1192196003789	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1192196003790	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1192196003791	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196003792	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1192196003793	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1192196003794	Cysteine-rich domain; Region: CCG; pfam02754
1192196003795	Cysteine-rich domain; Region: CCG; pfam02754
1192196003796	FAD binding domain; Region: FAD_binding_4; pfam01565
1192196003797	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1192196003798	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1192196003799	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1192196003800	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1192196003801	small acid-soluble spore protein SspI; Provisional; Region: PRK02955
1192196003802	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1192196003803	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1192196003804	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1192196003805	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1192196003806	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1192196003807	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1192196003808	dimer interface [polypeptide binding]; other site
1192196003809	motif 1; other site
1192196003810	active site
1192196003811	motif 2; other site
1192196003812	motif 3; other site
1192196003813	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1192196003814	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1192196003815	putative tRNA-binding site [nucleotide binding]; other site
1192196003816	B3/4 domain; Region: B3_4; pfam03483
1192196003817	tRNA synthetase B5 domain; Region: B5; smart00874
1192196003818	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1192196003819	dimer interface [polypeptide binding]; other site
1192196003820	motif 1; other site
1192196003821	motif 3; other site
1192196003822	motif 2; other site
1192196003823	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1192196003824	ribonuclease HIII; Provisional; Region: PRK00996
1192196003825	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1192196003826	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1192196003827	RNA/DNA hybrid binding site [nucleotide binding]; other site
1192196003828	active site
1192196003829	cell division protein ZapA; Provisional; Region: PRK14126
1192196003830	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1192196003831	Colicin V production protein; Region: Colicin_V; pfam02674
1192196003832	hypothetical protein; Provisional; Region: PRK08609
1192196003833	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
1192196003834	active site
1192196003835	primer binding site [nucleotide binding]; other site
1192196003836	NTP  binding site [chemical binding]; other site
1192196003837	metal binding triad [ion binding]; metal-binding site
1192196003838	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1192196003839	active site
1192196003840	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1192196003841	MutS domain III; Region: MutS_III; pfam05192
1192196003842	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1192196003843	Walker A/P-loop; other site
1192196003844	ATP binding site [chemical binding]; other site
1192196003845	Q-loop/lid; other site
1192196003846	ABC transporter signature motif; other site
1192196003847	Walker B; other site
1192196003848	D-loop; other site
1192196003849	H-loop/switch region; other site
1192196003850	Smr domain; Region: Smr; pfam01713
1192196003851	Predicted membrane protein [Function unknown]; Region: COG3766
1192196003852	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1192196003853	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1192196003854	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
1192196003855	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1192196003856	acyl-activating enzyme (AAE) consensus motif; other site
1192196003857	putative AMP binding site [chemical binding]; other site
1192196003858	putative active site [active]
1192196003859	putative CoA binding site [chemical binding]; other site
1192196003860	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196003861	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196003862	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
1192196003863	enoyl-CoA hydratase; Provisional; Region: PRK07658
1192196003864	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1192196003865	substrate binding site [chemical binding]; other site
1192196003866	oxyanion hole (OAH) forming residues; other site
1192196003867	trimer interface [polypeptide binding]; other site
1192196003868	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1192196003869	Ligand binding site [chemical binding]; other site
1192196003870	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1192196003871	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1192196003872	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1192196003873	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1192196003874	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1192196003875	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1192196003876	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1192196003877	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1192196003878	catalytic residues [active]
1192196003879	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1192196003880	aspartate kinase; Reviewed; Region: PRK06635
1192196003881	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1192196003882	putative nucleotide binding site [chemical binding]; other site
1192196003883	putative catalytic residues [active]
1192196003884	putative Mg ion binding site [ion binding]; other site
1192196003885	putative aspartate binding site [chemical binding]; other site
1192196003886	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1192196003887	putative allosteric regulatory site; other site
1192196003888	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1192196003889	putative allosteric regulatory residue; other site
1192196003890	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
1192196003891	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
1192196003892	putative Iron-sulfur protein interface [polypeptide binding]; other site
1192196003893	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1192196003894	proximal heme binding site [chemical binding]; other site
1192196003895	distal heme binding site [chemical binding]; other site
1192196003896	putative dimer interface [polypeptide binding]; other site
1192196003897	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
1192196003898	L-aspartate oxidase; Provisional; Region: PRK06175
1192196003899	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1192196003900	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
1192196003901	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1192196003902	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1192196003903	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1192196003904	active site
1192196003905	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1192196003906	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1192196003907	DNA binding residues [nucleotide binding]
1192196003908	dimerization interface [polypeptide binding]; other site
1192196003909	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196003910	MarR family; Region: MarR; pfam01047
1192196003911	glutamate racemase; Region: glut_race; TIGR00067
1192196003912	Spore germination protein [General function prediction only]; Region: COG5401
1192196003913	Sporulation and spore germination; Region: Germane; pfam10646
1192196003914	Sporulation and spore germination; Region: Germane; pfam10646
1192196003915	ribonuclease PH; Reviewed; Region: rph; PRK00173
1192196003916	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1192196003917	hexamer interface [polypeptide binding]; other site
1192196003918	active site
1192196003919	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1192196003920	active site
1192196003921	dimerization interface [polypeptide binding]; other site
1192196003922	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1192196003923	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1192196003924	active site
1192196003925	metal binding site [ion binding]; metal-binding site
1192196003926	homotetramer interface [polypeptide binding]; other site
1192196003927	conserved domain; Region: TIGR02271
1192196003928	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1192196003929	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196003930	Coenzyme A binding pocket [chemical binding]; other site
1192196003931	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
1192196003932	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1192196003933	PYR/PP interface [polypeptide binding]; other site
1192196003934	dimer interface [polypeptide binding]; other site
1192196003935	TPP binding site [chemical binding]; other site
1192196003936	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1192196003937	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1192196003938	TPP-binding site [chemical binding]; other site
1192196003939	dimer interface [polypeptide binding]; other site
1192196003940	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1192196003941	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1192196003942	putative valine binding site [chemical binding]; other site
1192196003943	dimer interface [polypeptide binding]; other site
1192196003944	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1192196003945	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1192196003946	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1192196003947	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1192196003948	2-isopropylmalate synthase; Validated; Region: PRK00915
1192196003949	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1192196003950	active site
1192196003951	catalytic residues [active]
1192196003952	metal binding site [ion binding]; metal-binding site
1192196003953	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1192196003954	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1192196003955	tartrate dehydrogenase; Region: TTC; TIGR02089
1192196003956	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1192196003957	substrate binding site [chemical binding]; other site
1192196003958	ligand binding site [chemical binding]; other site
1192196003959	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1192196003960	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1192196003961	substrate binding site [chemical binding]; other site
1192196003962	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196003963	TPR repeat; Region: TPR_11; pfam13414
1192196003964	TPR motif; other site
1192196003965	binding surface
1192196003966	trigger factor; Provisional; Region: tig; PRK01490
1192196003967	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1192196003968	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1192196003969	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1192196003970	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1192196003971	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196003972	Walker A motif; other site
1192196003973	ATP binding site [chemical binding]; other site
1192196003974	Walker B motif; other site
1192196003975	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1192196003976	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
1192196003977	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196003978	Walker A motif; other site
1192196003979	ATP binding site [chemical binding]; other site
1192196003980	Walker B motif; other site
1192196003981	arginine finger; other site
1192196003982	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1192196003983	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1192196003984	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1192196003985	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1192196003986	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196003987	Walker A motif; other site
1192196003988	ATP binding site [chemical binding]; other site
1192196003989	Walker B motif; other site
1192196003990	arginine finger; other site
1192196003991	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1192196003992	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1192196003993	G1 box; other site
1192196003994	GTP/Mg2+ binding site [chemical binding]; other site
1192196003995	Switch I region; other site
1192196003996	G2 box; other site
1192196003997	G3 box; other site
1192196003998	Switch II region; other site
1192196003999	G4 box; other site
1192196004000	G5 box; other site
1192196004001	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1192196004002	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1192196004003	tRNA; other site
1192196004004	putative tRNA binding site [nucleotide binding]; other site
1192196004005	putative NADP binding site [chemical binding]; other site
1192196004006	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1192196004007	Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578
1192196004008	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1192196004009	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1192196004010	domain interfaces; other site
1192196004011	active site
1192196004012	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1192196004013	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1192196004014	active site
1192196004015	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1192196004016	dimer interface [polypeptide binding]; other site
1192196004017	active site
1192196004018	Schiff base residues; other site
1192196004019	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1192196004020	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1192196004021	inhibitor-cofactor binding pocket; inhibition site
1192196004022	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196004023	catalytic residue [active]
1192196004024	stage VI sporulation protein D; Region: spore_VI_D; TIGR02907
1192196004025	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196004026	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
1192196004027	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1192196004028	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1192196004029	active site
1192196004030	HIGH motif; other site
1192196004031	nucleotide binding site [chemical binding]; other site
1192196004032	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1192196004033	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1192196004034	active site
1192196004035	KMSKS motif; other site
1192196004036	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1192196004037	tRNA binding surface [nucleotide binding]; other site
1192196004038	anticodon binding site; other site
1192196004039	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1192196004040	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1192196004041	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1192196004042	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1192196004043	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1192196004044	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1192196004045	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1192196004046	Sporulation related domain; Region: SPOR; pfam05036
1192196004047	Maf-like protein; Region: Maf; pfam02545
1192196004048	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1192196004049	active site
1192196004050	dimer interface [polypeptide binding]; other site
1192196004051	hypothetical protein; Reviewed; Region: PRK00024
1192196004052	Helix-hairpin-helix motif; Region: HHH; pfam00633
1192196004053	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1192196004054	MPN+ (JAMM) motif; other site
1192196004055	Zinc-binding site [ion binding]; other site
1192196004056	rod shape-determining protein MreB; Provisional; Region: PRK13927
1192196004057	MreB and similar proteins; Region: MreB_like; cd10225
1192196004058	nucleotide binding site [chemical binding]; other site
1192196004059	Mg binding site [ion binding]; other site
1192196004060	putative protofilament interaction site [polypeptide binding]; other site
1192196004061	RodZ interaction site [polypeptide binding]; other site
1192196004062	rod shape-determining protein MreC; Region: mreC; TIGR00219
1192196004063	rod shape-determining protein MreC; Region: MreC; pfam04085
1192196004064	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
1192196004065	septum formation inhibitor; Reviewed; Region: minC; PRK00513
1192196004066	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1192196004067	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1192196004068	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1192196004069	Switch I; other site
1192196004070	Switch II; other site
1192196004071	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1192196004072	Peptidase family M23; Region: Peptidase_M23; pfam01551
1192196004073	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
1192196004074	Peptidase family M50; Region: Peptidase_M50; pfam02163
1192196004075	active site
1192196004076	putative substrate binding region [chemical binding]; other site
1192196004077	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1192196004078	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1192196004079	hypothetical protein; Provisional; Region: PRK14553
1192196004080	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1192196004081	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1192196004082	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1192196004083	GTP1/OBG; Region: GTP1_OBG; pfam01018
1192196004084	Obg GTPase; Region: Obg; cd01898
1192196004085	G1 box; other site
1192196004086	GTP/Mg2+ binding site [chemical binding]; other site
1192196004087	Switch I region; other site
1192196004088	G2 box; other site
1192196004089	G3 box; other site
1192196004090	Switch II region; other site
1192196004091	G4 box; other site
1192196004092	G5 box; other site
1192196004093	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1192196004094	hypothetical protein; Provisional; Region: PRK04435
1192196004095	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
1192196004096	prephenate dehydratase; Provisional; Region: PRK11898
1192196004097	Prephenate dehydratase; Region: PDT; pfam00800
1192196004098	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1192196004099	putative L-Phe binding site [chemical binding]; other site
1192196004100	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
1192196004101	HTH domain; Region: HTH_11; pfam08279
1192196004102	3H domain; Region: 3H; pfam02829
1192196004103	cysteine desulfurase; Provisional; Region: PRK02948
1192196004104	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1192196004105	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1192196004106	catalytic residue [active]
1192196004107	L-aspartate oxidase; Provisional; Region: PRK08071
1192196004108	L-aspartate oxidase; Provisional; Region: PRK06175
1192196004109	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1192196004110	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
1192196004111	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1192196004112	dimerization interface [polypeptide binding]; other site
1192196004113	active site
1192196004114	quinolinate synthetase complex, A subunit; Region: nadA; TIGR00550
1192196004115	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196004116	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1192196004117	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1192196004118	hypothetical protein; Validated; Region: PRK00110
1192196004119	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1192196004120	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
1192196004121	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1192196004122	active site
1192196004123	substrate binding site [chemical binding]; other site
1192196004124	ATP binding site [chemical binding]; other site
1192196004125	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1192196004126	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1192196004127	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1192196004128	polyol permease family; Region: 2A0118; TIGR00897
1192196004129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196004130	putative substrate translocation pore; other site
1192196004131	Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977
1192196004132	BofC C-terminal domain; Region: BofC_C; pfam08955
1192196004133	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1192196004134	RuvA N terminal domain; Region: RuvA_N; pfam01330
1192196004135	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1192196004136	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1192196004137	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196004138	Walker A motif; other site
1192196004139	ATP binding site [chemical binding]; other site
1192196004140	Walker B motif; other site
1192196004141	arginine finger; other site
1192196004142	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1192196004143	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1192196004144	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1192196004145	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1192196004146	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1192196004147	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1192196004148	Protein of unknown function (DUF3792); Region: DUF3792; pfam12670
1192196004149	Predicted membrane protein [Function unknown]; Region: COG2323
1192196004150	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1192196004151	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1192196004152	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
1192196004153	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
1192196004154	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1192196004155	Protein export membrane protein; Region: SecD_SecF; pfam02355
1192196004156	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1192196004157	TrkA-C domain; Region: TrkA_C; pfam02080
1192196004158	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
1192196004159	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1192196004160	DHH family; Region: DHH; pfam01368
1192196004161	DHHA1 domain; Region: DHHA1; pfam02272
1192196004162	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
1192196004163	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1192196004164	active site
1192196004165	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1192196004166	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1192196004167	Zn2+ binding site [ion binding]; other site
1192196004168	Mg2+ binding site [ion binding]; other site
1192196004169	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1192196004170	synthetase active site [active]
1192196004171	NTP binding site [chemical binding]; other site
1192196004172	metal binding site [ion binding]; metal-binding site
1192196004173	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1192196004174	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1192196004175	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1192196004176	dimerization interface [polypeptide binding]; other site
1192196004177	putative tRNAtyr binding site [nucleotide binding]; other site
1192196004178	putative active site [active]
1192196004179	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
1192196004180	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1192196004181	Bacterial SH3 domain; Region: SH3_3; pfam08239
1192196004182	Bacterial SH3 domain; Region: SH3_3; pfam08239
1192196004183	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1192196004184	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1192196004185	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1192196004186	active site
1192196004187	metal binding site [ion binding]; metal-binding site
1192196004188	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1192196004189	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1192196004190	dimer interface [polypeptide binding]; other site
1192196004191	motif 1; other site
1192196004192	active site
1192196004193	motif 2; other site
1192196004194	motif 3; other site
1192196004195	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1192196004196	anticodon binding site; other site
1192196004197	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1192196004198	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1192196004199	dimer interface [polypeptide binding]; other site
1192196004200	anticodon binding site; other site
1192196004201	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1192196004202	homodimer interface [polypeptide binding]; other site
1192196004203	motif 1; other site
1192196004204	active site
1192196004205	motif 2; other site
1192196004206	GAD domain; Region: GAD; pfam02938
1192196004207	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1192196004208	motif 3; other site
1192196004209	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1192196004210	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1192196004211	putative ATP binding site [chemical binding]; other site
1192196004212	putative substrate interface [chemical binding]; other site
1192196004213	recombination factor protein RarA; Reviewed; Region: PRK13342
1192196004214	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196004215	Walker A motif; other site
1192196004216	ATP binding site [chemical binding]; other site
1192196004217	Walker B motif; other site
1192196004218	arginine finger; other site
1192196004219	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1192196004220	Predicted transcriptional regulator [Transcription]; Region: COG1959
1192196004221	Transcriptional regulator; Region: Rrf2; pfam02082
1192196004222	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1192196004223	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1192196004224	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1192196004225	catalytic residue [active]
1192196004226	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1192196004227	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1192196004228	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196004229	TPR motif; other site
1192196004230	TPR repeat; Region: TPR_11; pfam13414
1192196004231	binding surface
1192196004232	TPR repeat; Region: TPR_11; pfam13414
1192196004233	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196004234	binding surface
1192196004235	TPR motif; other site
1192196004236	TPR repeat; Region: TPR_11; pfam13414
1192196004237	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1192196004238	AAA domain; Region: AAA_30; pfam13604
1192196004239	Family description; Region: UvrD_C_2; pfam13538
1192196004240	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
1192196004241	amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726
1192196004242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196004243	dimer interface [polypeptide binding]; other site
1192196004244	ABC-ATPase subunit interface; other site
1192196004245	putative PBP binding loops; other site
1192196004246	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1192196004247	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196004248	dimer interface [polypeptide binding]; other site
1192196004249	conserved gate region; other site
1192196004250	putative PBP binding loops; other site
1192196004251	ABC-ATPase subunit interface; other site
1192196004252	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1192196004253	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1192196004254	substrate binding pocket [chemical binding]; other site
1192196004255	membrane-bound complex binding site; other site
1192196004256	hinge residues; other site
1192196004257	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1192196004258	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1192196004259	Walker A/P-loop; other site
1192196004260	ATP binding site [chemical binding]; other site
1192196004261	Q-loop/lid; other site
1192196004262	ABC transporter signature motif; other site
1192196004263	Walker B; other site
1192196004264	D-loop; other site
1192196004265	H-loop/switch region; other site
1192196004266	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1192196004267	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1192196004268	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1192196004269	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1192196004270	motif 1; other site
1192196004271	active site
1192196004272	motif 2; other site
1192196004273	motif 3; other site
1192196004274	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1192196004275	DHHA1 domain; Region: DHHA1; pfam02272
1192196004276	hypothetical protein; Provisional; Region: PRK05473
1192196004277	RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250
1192196004278	hypothetical protein; Provisional; Region: PRK13678
1192196004279	conserved hypothetical protein, YceG family; Region: TIGR00247
1192196004280	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1192196004281	dimerization interface [polypeptide binding]; other site
1192196004282	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1192196004283	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196004284	S-adenosylmethionine binding site [chemical binding]; other site
1192196004285	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1192196004286	Peptidase family U32; Region: Peptidase_U32; pfam01136
1192196004287	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1192196004288	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1192196004289	Peptidase family U32; Region: Peptidase_U32; pfam01136
1192196004290	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1192196004291	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1192196004292	ATP-binding site [chemical binding]; other site
1192196004293	Sugar specificity; other site
1192196004294	Pyrimidine base specificity; other site
1192196004295	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1192196004296	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1192196004297	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1192196004298	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1192196004299	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1192196004300	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1192196004301	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
1192196004302	Protein of unknown function (DUF2536); Region: DUF2536; pfam10750
1192196004303	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1192196004304	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196004305	S-adenosylmethionine binding site [chemical binding]; other site
1192196004306	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1192196004307	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1192196004308	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1192196004309	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1192196004310	dimer interface [polypeptide binding]; other site
1192196004311	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196004312	catalytic residue [active]
1192196004313	cystathionine beta-lyase; Provisional; Region: PRK07671
1192196004314	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1192196004315	homodimer interface [polypeptide binding]; other site
1192196004316	substrate-cofactor binding pocket; other site
1192196004317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196004318	catalytic residue [active]
1192196004319	YrhC-like protein; Region: YrhC; pfam14143
1192196004320	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1192196004321	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1192196004322	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1192196004323	catalytic loop [active]
1192196004324	iron binding site [ion binding]; other site
1192196004325	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1192196004326	4Fe-4S binding domain; Region: Fer4; pfam00037
1192196004327	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1192196004328	[4Fe-4S] binding site [ion binding]; other site
1192196004329	molybdopterin cofactor binding site; other site
1192196004330	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1192196004331	molybdopterin cofactor binding site; other site
1192196004332	Uncharacterized conserved protein [Function unknown]; Region: COG5609
1192196004333	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1192196004334	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
1192196004335	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196004336	S-adenosylmethionine binding site [chemical binding]; other site
1192196004337	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196004338	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196004339	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1192196004340	Cytochrome P450; Region: p450; pfam00067
1192196004341	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1192196004342	Flavodoxin; Region: Flavodoxin_1; pfam00258
1192196004343	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
1192196004344	FAD binding pocket [chemical binding]; other site
1192196004345	FAD binding motif [chemical binding]; other site
1192196004346	catalytic residues [active]
1192196004347	NAD binding pocket [chemical binding]; other site
1192196004348	phosphate binding motif [ion binding]; other site
1192196004349	beta-alpha-beta structure motif; other site
1192196004350	YrhK-like protein; Region: YrhK; pfam14145
1192196004351	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1192196004352	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1192196004353	catalytic triad [active]
1192196004354	catalytic triad [active]
1192196004355	oxyanion hole [active]
1192196004356	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
1192196004357	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1192196004358	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1192196004359	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196004360	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196004361	DNA binding residues [nucleotide binding]
1192196004362	Predicted transcriptional regulators [Transcription]; Region: COG1378
1192196004363	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
1192196004364	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
1192196004365	C-terminal domain interface [polypeptide binding]; other site
1192196004366	sugar binding site [chemical binding]; other site
1192196004367	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
1192196004368	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1192196004369	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1192196004370	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196004371	Walker A motif; other site
1192196004372	ATP binding site [chemical binding]; other site
1192196004373	Walker B motif; other site
1192196004374	arginine finger; other site
1192196004375	Transcriptional antiterminator [Transcription]; Region: COG3933
1192196004376	PRD domain; Region: PRD; pfam00874
1192196004377	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1192196004378	active pocket/dimerization site; other site
1192196004379	active site
1192196004380	phosphorylation site [posttranslational modification]
1192196004381	PRD domain; Region: PRD; pfam00874
1192196004382	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1192196004383	active pocket/dimerization site; other site
1192196004384	active site
1192196004385	phosphorylation site [posttranslational modification]
1192196004386	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1192196004387	active site
1192196004388	phosphorylation site [posttranslational modification]
1192196004389	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1192196004390	PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828
1192196004391	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1192196004392	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1192196004393	substrate binding [chemical binding]; other site
1192196004394	active site
1192196004395	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1192196004396	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
1192196004397	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1192196004398	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1192196004399	proposed catalytic triad [active]
1192196004400	conserved cys residue [active]
1192196004401	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1192196004402	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1192196004403	putative NAD(P) binding site [chemical binding]; other site
1192196004404	putative substrate binding site [chemical binding]; other site
1192196004405	catalytic Zn binding site [ion binding]; other site
1192196004406	structural Zn binding site [ion binding]; other site
1192196004407	dimer interface [polypeptide binding]; other site
1192196004408	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1192196004409	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1192196004410	DNA binding residues [nucleotide binding]
1192196004411	putative dimer interface [polypeptide binding]; other site
1192196004412	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1192196004413	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1192196004414	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1192196004415	NAD binding site [chemical binding]; other site
1192196004416	catalytic Zn binding site [ion binding]; other site
1192196004417	structural Zn binding site [ion binding]; other site
1192196004418	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1192196004419	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196004420	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1192196004421	active site
1192196004422	metal binding site [ion binding]; metal-binding site
1192196004423	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
1192196004424	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1192196004425	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
1192196004426	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1192196004427	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1192196004428	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1192196004429	Mor transcription activator family; Region: Mor; cl02360
1192196004430	Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978
1192196004431	chitosan binding site [chemical binding]; other site
1192196004432	catalytic residues [active]
1192196004433	PrpF protein; Region: PrpF; pfam04303
1192196004434	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196004435	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196004436	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1192196004437	dimerization interface [polypeptide binding]; other site
1192196004438	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
1192196004439	Citrate transporter; Region: CitMHS; pfam03600
1192196004440	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1192196004441	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1192196004442	active site
1192196004443	catalytic tetrad [active]
1192196004444	RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637
1192196004445	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196004446	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196004447	DNA binding residues [nucleotide binding]
1192196004448	YodA lipocalin-like domain; Region: YodA; pfam09223
1192196004449	Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427
1192196004450	putative binding site; other site
1192196004451	putative dimer interface [polypeptide binding]; other site
1192196004452	glutamate racemase; Region: glut_race; TIGR00067
1192196004453	Nitronate monooxygenase; Region: NMO; pfam03060
1192196004454	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1192196004455	FMN binding site [chemical binding]; other site
1192196004456	substrate binding site [chemical binding]; other site
1192196004457	putative catalytic residue [active]
1192196004458	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
1192196004459	DinB family; Region: DinB; pfam05163
1192196004460	DinB superfamily; Region: DinB_2; pfam12867
1192196004461	Protein of unknown function (DUF2568); Region: DUF2568; pfam10823
1192196004462	Isochorismatase family; Region: Isochorismatase; pfam00857
1192196004463	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1192196004464	catalytic triad [active]
1192196004465	conserved cis-peptide bond; other site
1192196004466	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1192196004467	Cytochrome P450; Region: p450; cl12078
1192196004468	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
1192196004469	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1192196004470	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196004471	putative DNA binding site [nucleotide binding]; other site
1192196004472	putative Zn2+ binding site [ion binding]; other site
1192196004473	AsnC family; Region: AsnC_trans_reg; pfam01037
1192196004474	4-azaleucine resistance probable transporter AzlC; Region: azlC; TIGR00346
1192196004475	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
1192196004476	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1192196004477	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1192196004478	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196004479	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196004480	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1192196004481	putative dimerization interface [polypeptide binding]; other site
1192196004482	Tautomerase enzyme; Region: Tautomerase; pfam01361
1192196004483	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1192196004484	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1192196004485	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1192196004486	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1192196004487	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196004488	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196004489	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1192196004490	putative dimerization interface [polypeptide binding]; other site
1192196004491	EamA-like transporter family; Region: EamA; pfam00892
1192196004492	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1192196004493	Domain of unknown function DUF21; Region: DUF21; pfam01595
1192196004494	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1192196004495	Transporter associated domain; Region: CorC_HlyC; smart01091
1192196004496	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1192196004497	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1192196004498	Coenzyme A binding pocket [chemical binding]; other site
1192196004499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196004500	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196004501	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196004502	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1192196004503	Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782
1192196004504	DNA binding residues [nucleotide binding]
1192196004505	dimer interface [polypeptide binding]; other site
1192196004506	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
1192196004507	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1192196004508	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1192196004509	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1192196004510	CPxP  motif; other site
1192196004511	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1192196004512	active site residue [active]
1192196004513	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1192196004514	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1192196004515	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1192196004516	CPxP  motif; other site
1192196004517	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1192196004518	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
1192196004519	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1192196004520	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196004521	Coenzyme A binding pocket [chemical binding]; other site
1192196004522	Predicted membrane protein [Function unknown]; Region: COG2311
1192196004523	Protein of unknown function (DUF418); Region: DUF418; cl12135
1192196004524	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1192196004525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196004526	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1192196004527	active site
1192196004528	phosphorylation site [posttranslational modification]
1192196004529	intermolecular recognition site; other site
1192196004530	dimerization interface [polypeptide binding]; other site
1192196004531	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1192196004532	DNA binding site [nucleotide binding]
1192196004533	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1192196004534	HAMP domain; Region: HAMP; pfam00672
1192196004535	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196004536	dimer interface [polypeptide binding]; other site
1192196004537	phosphorylation site [posttranslational modification]
1192196004538	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1192196004539	sporulation sigma factor SigK; Reviewed; Region: PRK05803
1192196004540	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196004541	DNA binding residues [nucleotide binding]
1192196004542	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1192196004543	hypothetical protein; Validated; Region: PRK06217
1192196004544	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
1192196004545	Predicted transcriptional regulators [Transcription]; Region: COG1695
1192196004546	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1192196004547	Domain of unknown function (DUF303); Region: DUF303; pfam03629
1192196004548	Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122
1192196004549	Uncharacterized conserved protein [Function unknown]; Region: COG5484
1192196004550	Phage terminase small subunit; Region: Phage_terminase; pfam10668
1192196004551	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1192196004552	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1192196004553	amidase catalytic site [active]
1192196004554	Zn binding residues [ion binding]; other site
1192196004555	substrate binding site [chemical binding]; other site
1192196004556	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196004557	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1192196004558	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1192196004559	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1192196004560	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1192196004561	NAD(P) binding site [chemical binding]; other site
1192196004562	active site
1192196004563	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196004564	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196004565	Necrosis inducing protein (NPP1); Region: NPP1; pfam05630
1192196004566	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1192196004567	Uncharacterized conserved protein [Function unknown]; Region: COG5444
1192196004568	A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411
1192196004569	TraX protein; Region: TraX; pfam05857
1192196004570	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1192196004571	binding surface
1192196004572	TPR motif; other site
1192196004573	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1192196004574	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1192196004575	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196004576	binding surface
1192196004577	TPR motif; other site
1192196004578	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1192196004579	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1192196004580	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1192196004581	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1192196004582	catalytic residues [active]
1192196004583	catalytic nucleophile [active]
1192196004584	Recombinase; Region: Recombinase; pfam07508
1192196004585	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1192196004586	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196004587	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196004588	putative substrate translocation pore; other site
1192196004589	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196004590	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196004591	MarR family; Region: MarR; pfam01047
1192196004592	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196004593	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
1192196004594	arginine decarboxylase; Provisional; Region: PRK15029
1192196004595	6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872
1192196004596	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1192196004597	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1192196004598	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1192196004599	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1192196004600	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1192196004601	amidase catalytic site [active]
1192196004602	Zn binding residues [ion binding]; other site
1192196004603	substrate binding site [chemical binding]; other site
1192196004604	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1192196004605	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1192196004606	GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657
1192196004607	active site
1192196004608	catalytic triad [active]
1192196004609	oxyanion hole [active]
1192196004610	Sporulation inhibitor A; Region: Sda; pfam08970
1192196004611	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1192196004612	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196004613	active site
1192196004614	motif I; other site
1192196004615	motif II; other site
1192196004616	GTPase YqeH; Provisional; Region: PRK13796
1192196004617	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1192196004618	GTP/Mg2+ binding site [chemical binding]; other site
1192196004619	G4 box; other site
1192196004620	G5 box; other site
1192196004621	G1 box; other site
1192196004622	Switch I region; other site
1192196004623	G2 box; other site
1192196004624	G3 box; other site
1192196004625	Switch II region; other site
1192196004626	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
1192196004627	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1192196004628	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1192196004629	shikimate binding site; other site
1192196004630	NAD(P) binding site [chemical binding]; other site
1192196004631	putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253
1192196004632	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1192196004633	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1192196004634	active site
1192196004635	(T/H)XGH motif; other site
1192196004636	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1192196004637	Zn2+ binding site [ion binding]; other site
1192196004638	Mg2+ binding site [ion binding]; other site
1192196004639	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1192196004640	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1192196004641	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196004642	S-adenosylmethionine binding site [chemical binding]; other site
1192196004643	late competence protein ComER; Validated; Region: PRK07680
1192196004644	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1192196004645	SLBB domain; Region: SLBB; pfam10531
1192196004646	comEA protein; Region: comE; TIGR01259
1192196004647	Helix-hairpin-helix motif; Region: HHH; pfam00633
1192196004648	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1192196004649	catalytic motif [active]
1192196004650	Zn binding site [ion binding]; other site
1192196004651	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1192196004652	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
1192196004653	Competence protein; Region: Competence; pfam03772
1192196004654	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1192196004655	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1192196004656	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1192196004657	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1192196004658	germination protease; Provisional; Region: PRK02858
1192196004659	Protein of unknown function (DUF3679); Region: DUF3679; pfam12438
1192196004660	GTP-binding protein LepA; Provisional; Region: PRK05433
1192196004661	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1192196004662	G1 box; other site
1192196004663	putative GEF interaction site [polypeptide binding]; other site
1192196004664	GTP/Mg2+ binding site [chemical binding]; other site
1192196004665	Switch I region; other site
1192196004666	G2 box; other site
1192196004667	G3 box; other site
1192196004668	Switch II region; other site
1192196004669	G4 box; other site
1192196004670	G5 box; other site
1192196004671	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1192196004672	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1192196004673	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1192196004674	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1192196004675	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196004676	FeS/SAM binding site; other site
1192196004677	HemN C-terminal domain; Region: HemN_C; pfam06969
1192196004678	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1192196004679	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1192196004680	GrpE; Region: GrpE; pfam01025
1192196004681	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1192196004682	dimer interface [polypeptide binding]; other site
1192196004683	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1192196004684	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1192196004685	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1192196004686	nucleotide binding site [chemical binding]; other site
1192196004687	NEF interaction site [polypeptide binding]; other site
1192196004688	SBD interface [polypeptide binding]; other site
1192196004689	chaperone protein DnaJ; Provisional; Region: PRK14280
1192196004690	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1192196004691	HSP70 interaction site [polypeptide binding]; other site
1192196004692	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1192196004693	substrate binding site [polypeptide binding]; other site
1192196004694	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1192196004695	Zn binding sites [ion binding]; other site
1192196004696	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1192196004697	dimer interface [polypeptide binding]; other site
1192196004698	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
1192196004699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196004700	S-adenosylmethionine binding site [chemical binding]; other site
1192196004701	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1192196004702	RNA methyltransferase, RsmE family; Region: TIGR00046
1192196004703	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1192196004704	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1192196004705	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196004706	FeS/SAM binding site; other site
1192196004707	TRAM domain; Region: TRAM; cl01282
1192196004708	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
1192196004709	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1192196004710	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1192196004711	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1192196004712	Yqey-like protein; Region: YqeY; pfam09424
1192196004713	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1192196004714	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
1192196004715	dimer interface [polypeptide binding]; other site
1192196004716	active site residues [active]
1192196004717	hypothetical protein; Provisional; Region: PRK13665
1192196004718	sporulation protein YqfC; Region: spore_yqfC; TIGR02856
1192196004719	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
1192196004720	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
1192196004721	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1192196004722	PhoH-like protein; Region: PhoH; pfam02562
1192196004723	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
1192196004724	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
1192196004725	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1192196004726	Zn2+ binding site [ion binding]; other site
1192196004727	Mg2+ binding site [ion binding]; other site
1192196004728	metal-binding heat shock protein; Provisional; Region: PRK00016
1192196004729	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1192196004730	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1192196004731	active site
1192196004732	catalytic motif [active]
1192196004733	Zn binding site [ion binding]; other site
1192196004734	GTPase Era; Reviewed; Region: era; PRK00089
1192196004735	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1192196004736	G1 box; other site
1192196004737	GTP/Mg2+ binding site [chemical binding]; other site
1192196004738	Switch I region; other site
1192196004739	G2 box; other site
1192196004740	Switch II region; other site
1192196004741	G3 box; other site
1192196004742	G4 box; other site
1192196004743	G5 box; other site
1192196004744	KH domain; Region: KH_2; pfam07650
1192196004745	Recombination protein O N terminal; Region: RecO_N; pfam11967
1192196004746	DNA repair protein RecO; Region: reco; TIGR00613
1192196004747	Recombination protein O C terminal; Region: RecO_C; pfam02565
1192196004748	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1192196004749	dimer interface [polypeptide binding]; other site
1192196004750	motif 1; other site
1192196004751	active site
1192196004752	motif 2; other site
1192196004753	motif 3; other site
1192196004754	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
1192196004755	HTH domain; Region: HTH_11; pfam08279
1192196004756	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
1192196004757	FOG: CBS domain [General function prediction only]; Region: COG0517
1192196004758	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1192196004759	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
1192196004760	DNA primase; Validated; Region: dnaG; PRK05667
1192196004761	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1192196004762	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1192196004763	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1192196004764	active site
1192196004765	metal binding site [ion binding]; metal-binding site
1192196004766	interdomain interaction site; other site
1192196004767	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1192196004768	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1192196004769	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1192196004770	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1192196004771	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196004772	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1192196004773	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196004774	DNA binding residues [nucleotide binding]
1192196004775	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1192196004776	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1192196004777	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1192196004778	Family of unknown function (DUF633); Region: DUF633; pfam04816
1192196004779	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1192196004780	dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486
1192196004781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1192196004782	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1192196004783	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
1192196004784	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1192196004785	LytB protein; Region: LYTB; pfam02401
1192196004786	YqfQ-like protein; Region: YqfQ; pfam14181
1192196004787	endonuclease IV; Provisional; Region: PRK01060
1192196004788	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1192196004789	AP (apurinic/apyrimidinic) site pocket; other site
1192196004790	DNA interaction; other site
1192196004791	Metal-binding active site; metal-binding site
1192196004792	Protein of unknown function (DUF2624); Region: DUF2624; pfam11116
1192196004793	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1192196004794	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1192196004795	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1192196004796	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1192196004797	ferric uptake regulator; Provisional; Region: fur; PRK09462
1192196004798	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1192196004799	metal binding site 2 [ion binding]; metal-binding site
1192196004800	putative DNA binding helix; other site
1192196004801	metal binding site 1 [ion binding]; metal-binding site
1192196004802	dimer interface [polypeptide binding]; other site
1192196004803	structural Zn2+ binding site [ion binding]; other site
1192196004804	Uncharacterized conserved protein [Function unknown]; Region: COG5663
1192196004805	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
1192196004806	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1192196004807	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1192196004808	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1192196004809	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196004810	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
1192196004811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
1192196004812	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1192196004813	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1192196004814	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1192196004815	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196004816	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196004817	putative substrate translocation pore; other site
1192196004818	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1192196004819	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1192196004820	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1192196004821	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1192196004822	PBP superfamily domain; Region: PBP_like_2; cl17296
1192196004823	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1192196004824	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1192196004825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196004826	dimer interface [polypeptide binding]; other site
1192196004827	conserved gate region; other site
1192196004828	putative PBP binding loops; other site
1192196004829	ABC-ATPase subunit interface; other site
1192196004830	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1192196004831	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196004832	dimer interface [polypeptide binding]; other site
1192196004833	conserved gate region; other site
1192196004834	ABC-ATPase subunit interface; other site
1192196004835	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248
1192196004836	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1192196004837	Walker A/P-loop; other site
1192196004838	ATP binding site [chemical binding]; other site
1192196004839	Q-loop/lid; other site
1192196004840	ABC transporter signature motif; other site
1192196004841	Walker B; other site
1192196004842	D-loop; other site
1192196004843	H-loop/switch region; other site
1192196004844	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274
1192196004845	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1192196004846	Walker A/P-loop; other site
1192196004847	ATP binding site [chemical binding]; other site
1192196004848	Q-loop/lid; other site
1192196004849	ABC transporter signature motif; other site
1192196004850	Walker B; other site
1192196004851	D-loop; other site
1192196004852	H-loop/switch region; other site
1192196004853	YceG-like family; Region: YceG; pfam02618
1192196004854	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1192196004855	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1192196004856	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1192196004857	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1192196004858	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1192196004859	Rhomboid family; Region: Rhomboid; pfam01694
1192196004860	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196004861	binding surface
1192196004862	TPR motif; other site
1192196004863	TPR repeat; Region: TPR_11; pfam13414
1192196004864	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
1192196004865	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1192196004866	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1192196004867	nucleotide binding site [chemical binding]; other site
1192196004868	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1192196004869	Sulfatase; Region: Sulfatase; pfam00884
1192196004870	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
1192196004871	Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229
1192196004872	putative active site [active]
1192196004873	Zn binding site [ion binding]; other site
1192196004874	uncharacterized protein, MTH1187 family; Region: TIGR00106
1192196004875	Protein of unknown function (DUF2759); Region: DUF2759; pfam10958
1192196004876	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1192196004877	Protein of unknown function (DUF2626); Region: DUF2626; pfam11117
1192196004878	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1192196004879	ArsC family; Region: ArsC; pfam03960
1192196004880	putative catalytic residues [active]
1192196004881	thiol/disulfide switch; other site
1192196004882	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1192196004883	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1192196004884	Domain of unknown function DUF21; Region: DUF21; pfam01595
1192196004885	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1192196004886	Transporter associated domain; Region: CorC_HlyC; smart01091
1192196004887	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1192196004888	Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821
1192196004889	Cl binding site [ion binding]; other site
1192196004890	oligomer interface [polypeptide binding]; other site
1192196004891	Type II/IV secretion system protein; Region: T2SE; pfam00437
1192196004892	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1192196004893	Walker A motif; other site
1192196004894	ATP binding site [chemical binding]; other site
1192196004895	Walker B motif; other site
1192196004896	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1192196004897	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1192196004898	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1192196004899	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1192196004900	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1192196004901	ComG operon protein 7; Region: ComGG; pfam14173
1192196004902	YqzE-like protein; Region: YqzE; pfam14038
1192196004903	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
1192196004904	YqxM protein; Region: YqxM_for_SipW; TIGR04087
1192196004905	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
1192196004906	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1192196004907	Catalytic site [active]
1192196004908	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
1192196004909	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1192196004910	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1192196004911	non-specific DNA binding site [nucleotide binding]; other site
1192196004912	salt bridge; other site
1192196004913	sequence-specific DNA binding site [nucleotide binding]; other site
1192196004914	Anti-repressor SinI; Region: SinI; pfam08671
1192196004915	Anti-repressor SinI; Region: SinI; pfam08671
1192196004916	Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079
1192196004917	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1192196004918	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1192196004919	ATP binding site [chemical binding]; other site
1192196004920	putative Mg++ binding site [ion binding]; other site
1192196004921	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1192196004922	nucleotide binding region [chemical binding]; other site
1192196004923	ATP-binding site [chemical binding]; other site
1192196004924	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1192196004925	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1192196004926	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1192196004927	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
1192196004928	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1192196004929	tetramer interface [polypeptide binding]; other site
1192196004930	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196004931	catalytic residue [active]
1192196004932	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1192196004933	tetramer interface [polypeptide binding]; other site
1192196004934	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196004935	catalytic residue [active]
1192196004936	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1192196004937	active site residue [active]
1192196004938	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1192196004939	manganese transport transcriptional regulator; Provisional; Region: PRK03902
1192196004940	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1192196004941	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1192196004942	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1192196004943	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
1192196004944	active site
1192196004945	nucleophile elbow; other site
1192196004946	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
1192196004947	Conserved membrane protein YqhR; Region: YqhR; pfam11085
1192196004948	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1192196004949	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1192196004950	trimer interface [polypeptide binding]; other site
1192196004951	active site
1192196004952	dimer interface [polypeptide binding]; other site
1192196004953	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1192196004954	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1192196004955	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1192196004956	active site
1192196004957	elongation factor P; Validated; Region: PRK00529
1192196004958	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1192196004959	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1192196004960	RNA binding site [nucleotide binding]; other site
1192196004961	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1192196004962	RNA binding site [nucleotide binding]; other site
1192196004963	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
1192196004964	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
1192196004965	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196004966	Walker A motif; other site
1192196004967	ATP binding site [chemical binding]; other site
1192196004968	Walker B motif; other site
1192196004969	arginine finger; other site
1192196004970	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
1192196004971	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
1192196004972	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
1192196004973	stage III sporulation protein AE; Region: spore_III_AE; TIGR02829
1192196004974	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
1192196004975	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
1192196004976	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
1192196004977	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1192196004978	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1192196004979	carboxyltransferase (CT) interaction site; other site
1192196004980	biotinylation site [posttranslational modification]; other site
1192196004981	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1192196004982	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1192196004983	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1192196004984	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1192196004985	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1192196004986	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1192196004987	putative RNA binding site [nucleotide binding]; other site
1192196004988	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
1192196004989	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1192196004990	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1192196004991	homodimer interface [polypeptide binding]; other site
1192196004992	NADP binding site [chemical binding]; other site
1192196004993	substrate binding site [chemical binding]; other site
1192196004994	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
1192196004995	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1192196004996	generic binding surface II; other site
1192196004997	generic binding surface I; other site
1192196004998	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
1192196004999	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1192196005000	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1192196005001	substrate binding pocket [chemical binding]; other site
1192196005002	chain length determination region; other site
1192196005003	substrate-Mg2+ binding site; other site
1192196005004	catalytic residues [active]
1192196005005	aspartate-rich region 1; other site
1192196005006	active site lid residues [active]
1192196005007	aspartate-rich region 2; other site
1192196005008	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
1192196005009	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1192196005010	TPP-binding site; other site
1192196005011	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1192196005012	PYR/PP interface [polypeptide binding]; other site
1192196005013	dimer interface [polypeptide binding]; other site
1192196005014	TPP binding site [chemical binding]; other site
1192196005015	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1192196005016	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1192196005017	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1192196005018	RNA binding surface [nucleotide binding]; other site
1192196005019	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1192196005020	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1192196005021	arginine repressor; Provisional; Region: PRK04280
1192196005022	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1192196005023	DNA repair protein RecN; Region: recN; TIGR00634
1192196005024	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1192196005025	Walker A/P-loop; other site
1192196005026	ATP binding site [chemical binding]; other site
1192196005027	Q-loop/lid; other site
1192196005028	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1192196005029	ABC transporter signature motif; other site
1192196005030	Walker B; other site
1192196005031	D-loop; other site
1192196005032	H-loop/switch region; other site
1192196005033	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
1192196005034	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1192196005035	protein binding site [polypeptide binding]; other site
1192196005036	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
1192196005037	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
1192196005038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196005039	active site
1192196005040	phosphorylation site [posttranslational modification]
1192196005041	intermolecular recognition site; other site
1192196005042	dimerization interface [polypeptide binding]; other site
1192196005043	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
1192196005044	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1192196005045	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1192196005046	putative active site [active]
1192196005047	putative FMN binding site [chemical binding]; other site
1192196005048	putative substrate binding site [chemical binding]; other site
1192196005049	putative catalytic residue [active]
1192196005050	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1192196005051	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
1192196005052	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1192196005053	active site
1192196005054	metal binding site [ion binding]; metal-binding site
1192196005055	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1192196005056	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
1192196005057	active site
1192196005058	catalytic site [active]
1192196005059	metal binding site [ion binding]; metal-binding site
1192196005060	dimer interface [polypeptide binding]; other site
1192196005061	acetyl-CoA acetyltransferase; Provisional; Region: PRK08235
1192196005062	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1192196005063	dimer interface [polypeptide binding]; other site
1192196005064	active site
1192196005065	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1192196005066	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1192196005067	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1192196005068	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1192196005069	FAD binding site [chemical binding]; other site
1192196005070	homotetramer interface [polypeptide binding]; other site
1192196005071	substrate binding pocket [chemical binding]; other site
1192196005072	catalytic base [active]
1192196005073	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
1192196005074	dimer interface [polypeptide binding]; other site
1192196005075	Citrate synthase; Region: Citrate_synt; pfam00285
1192196005076	active site
1192196005077	coenzyme A binding site [chemical binding]; other site
1192196005078	citrylCoA binding site [chemical binding]; other site
1192196005079	oxalacetate/citrate binding site [chemical binding]; other site
1192196005080	catalytic triad [active]
1192196005081	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
1192196005082	2-methylcitrate dehydratase; Region: prpD; TIGR02330
1192196005083	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1192196005084	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1192196005085	tetramer interface [polypeptide binding]; other site
1192196005086	active site
1192196005087	Mg2+/Mn2+ binding site [ion binding]; other site
1192196005088	Protein of unknown function (DUF2627); Region: DUF2627; pfam11118
1192196005089	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1192196005090	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196005091	putative active site [active]
1192196005092	heme pocket [chemical binding]; other site
1192196005093	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196005094	putative active site [active]
1192196005095	heme pocket [chemical binding]; other site
1192196005096	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196005097	Walker A motif; other site
1192196005098	ATP binding site [chemical binding]; other site
1192196005099	Walker B motif; other site
1192196005100	arginine finger; other site
1192196005101	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1192196005102	phosphate butyryltransferase; Validated; Region: PRK07742
1192196005103	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1192196005104	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1192196005105	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
1192196005106	NAD binding site [chemical binding]; other site
1192196005107	Phe binding site; other site
1192196005108	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1192196005109	nucleotide binding site [chemical binding]; other site
1192196005110	Acetokinase family; Region: Acetate_kinase; cl17229
1192196005111	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1192196005112	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1192196005113	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1192196005114	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1192196005115	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1192196005116	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1192196005117	tetramer interface [polypeptide binding]; other site
1192196005118	TPP-binding site [chemical binding]; other site
1192196005119	heterodimer interface [polypeptide binding]; other site
1192196005120	phosphorylation loop region [posttranslational modification]
1192196005121	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1192196005122	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1192196005123	alpha subunit interface [polypeptide binding]; other site
1192196005124	TPP binding site [chemical binding]; other site
1192196005125	heterodimer interface [polypeptide binding]; other site
1192196005126	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1192196005127	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1192196005128	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1192196005129	E3 interaction surface; other site
1192196005130	lipoyl attachment site [posttranslational modification]; other site
1192196005131	e3 binding domain; Region: E3_binding; pfam02817
1192196005132	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1192196005133	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1192196005134	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1192196005135	DNA binding residues [nucleotide binding]
1192196005136	drug binding residues [chemical binding]; other site
1192196005137	dimer interface [polypeptide binding]; other site
1192196005138	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
1192196005139	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196005140	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196005141	lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147
1192196005142	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1192196005143	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1192196005144	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1192196005145	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1192196005146	substrate binding pocket [chemical binding]; other site
1192196005147	membrane-bound complex binding site; other site
1192196005148	hinge residues; other site
1192196005149	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1192196005150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196005151	dimer interface [polypeptide binding]; other site
1192196005152	conserved gate region; other site
1192196005153	putative PBP binding loops; other site
1192196005154	ABC-ATPase subunit interface; other site
1192196005155	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1192196005156	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1192196005157	Walker A/P-loop; other site
1192196005158	ATP binding site [chemical binding]; other site
1192196005159	Q-loop/lid; other site
1192196005160	ABC transporter signature motif; other site
1192196005161	Walker B; other site
1192196005162	D-loop; other site
1192196005163	H-loop/switch region; other site
1192196005164	Predicted membrane protein [Function unknown]; Region: COG4129
1192196005165	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1192196005166	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1192196005167	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1192196005168	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1192196005169	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196005170	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1192196005171	dimer interface [polypeptide binding]; other site
1192196005172	substrate binding site [chemical binding]; other site
1192196005173	metal binding site [ion binding]; metal-binding site
1192196005174	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1192196005175	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1192196005176	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1192196005177	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
1192196005178	peptidase T-like protein; Region: PepT-like; TIGR01883
1192196005179	metal binding site [ion binding]; metal-binding site
1192196005180	putative dimer interface [polypeptide binding]; other site
1192196005181	Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329
1192196005182	OxaA-like protein precursor; Validated; Region: PRK01622
1192196005183	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
1192196005184	DNA polymerase IV; Validated; Region: PRK01810
1192196005185	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1192196005186	active site
1192196005187	DNA binding site [nucleotide binding]
1192196005188	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1192196005189	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1192196005190	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1192196005191	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1192196005192	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1192196005193	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1192196005194	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1192196005195	putative hydrolase; Provisional; Region: PRK02113
1192196005196	ribonuclease Z; Region: RNase_Z; TIGR02651
1192196005197	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1192196005198	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1192196005199	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1192196005200	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1192196005201	active site
1192196005202	FMN binding site [chemical binding]; other site
1192196005203	substrate binding site [chemical binding]; other site
1192196005204	homotetramer interface [polypeptide binding]; other site
1192196005205	catalytic residue [active]
1192196005206	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
1192196005207	putative metal binding site [ion binding]; other site
1192196005208	putative dimer interface [polypeptide binding]; other site
1192196005209	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1192196005210	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
1192196005211	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1192196005212	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1192196005213	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332
1192196005214	NADP binding site [chemical binding]; other site
1192196005215	homodimer interface [polypeptide binding]; other site
1192196005216	substrate binding site [chemical binding]; other site
1192196005217	active site
1192196005218	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
1192196005219	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1192196005220	catalytic residue [active]
1192196005221	pantothenate kinase; Provisional; Region: PRK05439
1192196005222	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1192196005223	ATP-binding site [chemical binding]; other site
1192196005224	CoA-binding site [chemical binding]; other site
1192196005225	Mg2+-binding site [ion binding]; other site
1192196005226	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
1192196005227	putative dimer interface [polypeptide binding]; other site
1192196005228	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196005229	ligand binding site [chemical binding]; other site
1192196005230	Zn binding site [ion binding]; other site
1192196005231	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196005232	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196005233	putative substrate translocation pore; other site
1192196005234	YqzH-like protein; Region: YqzH; pfam14164
1192196005235	YolD-like protein; Region: YolD; pfam08863
1192196005236	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1192196005237	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196005238	Coenzyme A binding pocket [chemical binding]; other site
1192196005239	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1192196005240	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1192196005241	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196005242	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1192196005243	Coenzyme A binding pocket [chemical binding]; other site
1192196005244	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1192196005245	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
1192196005246	Protein of unknown function (DUF2552); Region: DUF2552; pfam10827
1192196005247	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1192196005248	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1192196005249	Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705
1192196005250	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1192196005251	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1192196005252	active site
1192196005253	catalytic tetrad [active]
1192196005254	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
1192196005255	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1192196005256	dimer interface [polypeptide binding]; other site
1192196005257	ADP-ribose binding site [chemical binding]; other site
1192196005258	active site
1192196005259	nudix motif; other site
1192196005260	metal binding site [ion binding]; metal-binding site
1192196005261	TIGR00375 family protein; Region: TIGR00375
1192196005262	PHP-associated; Region: PHP_C; pfam13263
1192196005263	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1192196005264	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1192196005265	non-specific DNA binding site [nucleotide binding]; other site
1192196005266	salt bridge; other site
1192196005267	sequence-specific DNA binding site [nucleotide binding]; other site
1192196005268	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
1192196005269	active site
1192196005270	homodimer interface [polypeptide binding]; other site
1192196005271	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1192196005272	Aspartase; Region: Aspartase; cd01357
1192196005273	active sites [active]
1192196005274	tetramer interface [polypeptide binding]; other site
1192196005275	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1192196005276	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
1192196005277	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1192196005278	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1192196005279	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1192196005280	NAD(P) binding pocket [chemical binding]; other site
1192196005281	stage II sporulation protein M; Region: spo_II_M; TIGR02831
1192196005282	ferric uptake regulator; Provisional; Region: fur; PRK09462
1192196005283	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1192196005284	metal binding site 2 [ion binding]; metal-binding site
1192196005285	putative DNA binding helix; other site
1192196005286	metal binding site 1 [ion binding]; metal-binding site
1192196005287	dimer interface [polypeptide binding]; other site
1192196005288	structural Zn2+ binding site [ion binding]; other site
1192196005289	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1192196005290	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1192196005291	active site
1192196005292	Int/Topo IB signature motif; other site
1192196005293	phosphopentomutase; Provisional; Region: PRK05362
1192196005294	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1192196005295	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1192196005296	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1192196005297	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1192196005298	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1192196005299	anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886
1192196005300	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1192196005301	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196005302	ATP binding site [chemical binding]; other site
1192196005303	Mg2+ binding site [ion binding]; other site
1192196005304	G-X-G motif; other site
1192196005305	sporulation sigma factor SigF; Validated; Region: PRK05572
1192196005306	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196005307	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1192196005308	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196005309	DNA binding residues [nucleotide binding]
1192196005310	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
1192196005311	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
1192196005312	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
1192196005313	stage V sporulation protein AD; Validated; Region: PRK08304
1192196005314	stage V sporulation protein AD; Provisional; Region: PRK12404
1192196005315	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
1192196005316	Stage V sporulation protein AE1; Region: SpoVAE; pfam14097
1192196005317	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1192196005318	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1192196005319	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1192196005320	active site
1192196005321	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1192196005322	substrate binding site [chemical binding]; other site
1192196005323	catalytic residues [active]
1192196005324	dimer interface [polypeptide binding]; other site
1192196005325	Predicted secreted protein [Function unknown]; Region: COG4086
1192196005326	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
1192196005327	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1192196005328	active site
1192196005329	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1192196005330	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1192196005331	active site
1192196005332	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855
1192196005333	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1192196005334	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1192196005335	Catalytic site [active]
1192196005336	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1192196005337	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1192196005338	catalytic motif [active]
1192196005339	Zn binding site [ion binding]; other site
1192196005340	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
1192196005341	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1192196005342	Lumazine binding domain; Region: Lum_binding; pfam00677
1192196005343	Lumazine binding domain; Region: Lum_binding; pfam00677
1192196005344	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1192196005345	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1192196005346	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1192196005347	dimerization interface [polypeptide binding]; other site
1192196005348	active site
1192196005349	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1192196005350	homopentamer interface [polypeptide binding]; other site
1192196005351	active site
1192196005352	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196005353	Coenzyme A binding pocket [chemical binding]; other site
1192196005354	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
1192196005355	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1192196005356	segregation and condensation protein B; Region: TIGR00281
1192196005357	Protein of unknown function (DUF3907); Region: DUF3907; pfam13047
1192196005358	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1192196005359	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1192196005360	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1192196005361	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
1192196005362	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
1192196005363	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1192196005364	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1192196005365	RNA binding surface [nucleotide binding]; other site
1192196005366	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1192196005367	active site
1192196005368	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1192196005369	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1192196005370	catalytic residues [active]
1192196005371	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
1192196005372	ResB-like family; Region: ResB; pfam05140
1192196005373	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1192196005374	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1192196005375	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1192196005376	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196005377	active site
1192196005378	phosphorylation site [posttranslational modification]
1192196005379	intermolecular recognition site; other site
1192196005380	dimerization interface [polypeptide binding]; other site
1192196005381	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1192196005382	DNA binding site [nucleotide binding]
1192196005383	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1192196005384	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196005385	dimerization interface [polypeptide binding]; other site
1192196005386	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196005387	putative active site [active]
1192196005388	heme pocket [chemical binding]; other site
1192196005389	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196005390	dimer interface [polypeptide binding]; other site
1192196005391	phosphorylation site [posttranslational modification]
1192196005392	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196005393	ATP binding site [chemical binding]; other site
1192196005394	Mg2+ binding site [ion binding]; other site
1192196005395	G-X-G motif; other site
1192196005396	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
1192196005397	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196005398	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196005399	DNA binding residues [nucleotide binding]
1192196005400	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1192196005401	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1192196005402	active site
1192196005403	catalytic residue [active]
1192196005404	dimer interface [polypeptide binding]; other site
1192196005405	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
1192196005406	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1192196005407	ligand binding site [chemical binding]; other site
1192196005408	NAD binding site [chemical binding]; other site
1192196005409	dimerization interface [polypeptide binding]; other site
1192196005410	catalytic site [active]
1192196005411	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1192196005412	putative L-serine binding site [chemical binding]; other site
1192196005413	Predicted membrane protein [Function unknown]; Region: COG3601
1192196005414	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1192196005415	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1192196005416	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1192196005417	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1192196005418	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1192196005419	ATP binding site [chemical binding]; other site
1192196005420	putative Mg++ binding site [ion binding]; other site
1192196005421	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1192196005422	nucleotide binding region [chemical binding]; other site
1192196005423	ATP-binding site [chemical binding]; other site
1192196005424	CAAX protease self-immunity; Region: Abi; pfam02517
1192196005425	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196005426	Protein of unknown function (DUF2663); Region: DUF2663; pfam10864
1192196005427	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1192196005428	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1192196005429	putative active site [active]
1192196005430	putative metal binding site [ion binding]; other site
1192196005431	adaptor protein; Provisional; Region: PRK02899
1192196005432	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1192196005433	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1192196005434	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1192196005435	NAD(P) binding site [chemical binding]; other site
1192196005436	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1192196005437	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1192196005438	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1192196005439	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1192196005440	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1192196005441	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1192196005442	germination protein YpeB; Region: spore_YpeB; TIGR02889
1192196005443	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
1192196005444	Flagellar protein YcgR; Region: YcgR_2; pfam12945
1192196005445	PilZ domain; Region: PilZ; pfam07238
1192196005446	cytidylate kinase; Provisional; Region: cmk; PRK00023
1192196005447	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1192196005448	CMP-binding site; other site
1192196005449	The sites determining sugar specificity; other site
1192196005450	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1192196005451	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1192196005452	RNA binding site [nucleotide binding]; other site
1192196005453	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1192196005454	RNA binding site [nucleotide binding]; other site
1192196005455	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1192196005456	RNA binding site [nucleotide binding]; other site
1192196005457	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1192196005458	RNA binding site [nucleotide binding]; other site
1192196005459	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1192196005460	phosphate binding site [ion binding]; other site
1192196005461	YIEGIA protein; Region: YIEGIA; pfam14045
1192196005462	GTP-binding protein Der; Reviewed; Region: PRK00093
1192196005463	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1192196005464	G1 box; other site
1192196005465	GTP/Mg2+ binding site [chemical binding]; other site
1192196005466	Switch I region; other site
1192196005467	G2 box; other site
1192196005468	Switch II region; other site
1192196005469	G3 box; other site
1192196005470	G4 box; other site
1192196005471	G5 box; other site
1192196005472	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1192196005473	G1 box; other site
1192196005474	GTP/Mg2+ binding site [chemical binding]; other site
1192196005475	Switch I region; other site
1192196005476	G2 box; other site
1192196005477	G3 box; other site
1192196005478	Switch II region; other site
1192196005479	G4 box; other site
1192196005480	G5 box; other site
1192196005481	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1192196005482	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1192196005483	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1192196005484	Protein of unknown function (DUF2768); Region: DUF2768; pfam10966
1192196005485	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
1192196005486	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
1192196005487	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1192196005488	IHF dimer interface [polypeptide binding]; other site
1192196005489	IHF - DNA interface [nucleotide binding]; other site
1192196005490	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1192196005491	homodecamer interface [polypeptide binding]; other site
1192196005492	GTP cyclohydrolase I; Provisional; Region: PLN03044
1192196005493	active site
1192196005494	putative catalytic site residues [active]
1192196005495	zinc binding site [ion binding]; other site
1192196005496	GTP-CH-I/GFRP interaction surface; other site
1192196005497	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
1192196005498	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
1192196005499	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196005500	S-adenosylmethionine binding site [chemical binding]; other site
1192196005501	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1192196005502	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1192196005503	substrate binding pocket [chemical binding]; other site
1192196005504	chain length determination region; other site
1192196005505	substrate-Mg2+ binding site; other site
1192196005506	catalytic residues [active]
1192196005507	aspartate-rich region 1; other site
1192196005508	active site lid residues [active]
1192196005509	aspartate-rich region 2; other site
1192196005510	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1192196005511	active site
1192196005512	multimer interface [polypeptide binding]; other site
1192196005513	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
1192196005514	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1192196005515	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1192196005516	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1192196005517	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1192196005518	Tetramer interface [polypeptide binding]; other site
1192196005519	FMN-binding site [chemical binding]; other site
1192196005520	active site
1192196005521	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1192196005522	active site
1192196005523	dimer interface [polypeptide binding]; other site
1192196005524	metal binding site [ion binding]; metal-binding site
1192196005525	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
1192196005526	homotrimer interaction site [polypeptide binding]; other site
1192196005527	active site
1192196005528	anthranilate synthase component I; Provisional; Region: PRK13569
1192196005529	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1192196005530	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1192196005531	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1192196005532	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1192196005533	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1192196005534	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1192196005535	active site
1192196005536	ribulose/triose binding site [chemical binding]; other site
1192196005537	phosphate binding site [ion binding]; other site
1192196005538	substrate (anthranilate) binding pocket [chemical binding]; other site
1192196005539	product (indole) binding pocket [chemical binding]; other site
1192196005540	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1192196005541	active site
1192196005542	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1192196005543	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1192196005544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196005545	catalytic residue [active]
1192196005546	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1192196005547	substrate binding site [chemical binding]; other site
1192196005548	active site
1192196005549	catalytic residues [active]
1192196005550	heterodimer interface [polypeptide binding]; other site
1192196005551	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1192196005552	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196005553	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196005554	homodimer interface [polypeptide binding]; other site
1192196005555	catalytic residue [active]
1192196005556	prephenate dehydrogenase; Validated; Region: PRK06545
1192196005557	prephenate dehydrogenase; Validated; Region: PRK08507
1192196005558	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1192196005559	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1192196005560	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1192196005561	hinge; other site
1192196005562	active site
1192196005563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1192196005564	TPR motif; other site
1192196005565	binding surface
1192196005566	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1192196005567	binding surface
1192196005568	TPR motif; other site
1192196005569	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1192196005570	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196005571	TPR motif; other site
1192196005572	binding surface
1192196005573	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1192196005574	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196005575	binding surface
1192196005576	TPR motif; other site
1192196005577	hypothetical protein; Provisional; Region: PRK03636
1192196005578	UPF0302 domain; Region: UPF0302; pfam08864
1192196005579	IDEAL domain; Region: IDEAL; pfam08858
1192196005580	Protein of unknown function (DUF2487); Region: DUF2487; pfam10673
1192196005581	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1192196005582	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
1192196005583	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1192196005584	iron-sulfur cluster [ion binding]; other site
1192196005585	[2Fe-2S] cluster binding site [ion binding]; other site
1192196005586	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1192196005587	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1192196005588	interchain domain interface [polypeptide binding]; other site
1192196005589	intrachain domain interface; other site
1192196005590	heme bH binding site [chemical binding]; other site
1192196005591	Qi binding site; other site
1192196005592	heme bL binding site [chemical binding]; other site
1192196005593	Qo binding site; other site
1192196005594	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1192196005595	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
1192196005596	intrachain domain interface; other site
1192196005597	Qi binding site; other site
1192196005598	Qo binding site; other site
1192196005599	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1192196005600	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1192196005601	Predicted membrane protein [Function unknown]; Region: COG4347
1192196005602	Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577
1192196005603	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1192196005604	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1192196005605	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1192196005606	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
1192196005607	homodimer interface [polypeptide binding]; other site
1192196005608	metal binding site [ion binding]; metal-binding site
1192196005609	dihydrodipicolinate reductase; Region: dapB; TIGR00036
1192196005610	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1192196005611	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1192196005612	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1192196005613	active site
1192196005614	dimer interfaces [polypeptide binding]; other site
1192196005615	catalytic residues [active]
1192196005616	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
1192196005617	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1192196005618	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
1192196005619	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1192196005620	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1192196005621	active site
1192196005622	NTP binding site [chemical binding]; other site
1192196005623	metal binding triad [ion binding]; metal-binding site
1192196005624	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1192196005625	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1192196005626	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1192196005627	birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121
1192196005628	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1192196005629	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1192196005630	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1192196005631	oligomerization interface [polypeptide binding]; other site
1192196005632	active site
1192196005633	metal binding site [ion binding]; metal-binding site
1192196005634	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1192196005635	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1192196005636	active site
1192196005637	ATP-binding site [chemical binding]; other site
1192196005638	pantoate-binding site; other site
1192196005639	HXXH motif; other site
1192196005640	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1192196005641	tetramerization interface [polypeptide binding]; other site
1192196005642	active site
1192196005643	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
1192196005644	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1192196005645	active site
1192196005646	catalytic site [active]
1192196005647	substrate binding site [chemical binding]; other site
1192196005648	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1192196005649	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1192196005650	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
1192196005651	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1192196005652	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1192196005653	aspartate aminotransferase; Provisional; Region: PRK05764
1192196005654	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196005655	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196005656	homodimer interface [polypeptide binding]; other site
1192196005657	catalytic residue [active]
1192196005658	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1192196005659	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1192196005660	putative dimer interface [polypeptide binding]; other site
1192196005661	putative anticodon binding site; other site
1192196005662	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1192196005663	homodimer interface [polypeptide binding]; other site
1192196005664	motif 1; other site
1192196005665	motif 2; other site
1192196005666	active site
1192196005667	motif 3; other site
1192196005668	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1192196005669	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1192196005670	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1192196005671	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1192196005672	minor groove reading motif; other site
1192196005673	helix-hairpin-helix signature motif; other site
1192196005674	substrate binding pocket [chemical binding]; other site
1192196005675	active site
1192196005676	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
1192196005677	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1192196005678	Transglycosylase; Region: Transgly; pfam00912
1192196005679	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1192196005680	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1192196005681	Interdomain contacts; other site
1192196005682	Cytokine receptor motif; other site
1192196005683	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1192196005684	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
1192196005685	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
1192196005686	YppF-like protein; Region: YppF; pfam14178
1192196005687	YppG-like protein; Region: YppG; pfam14179
1192196005688	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
1192196005689	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1192196005690	HPr interaction site; other site
1192196005691	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1192196005692	active site
1192196005693	phosphorylation site [posttranslational modification]
1192196005694	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
1192196005695	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1192196005696	ATP binding site [chemical binding]; other site
1192196005697	putative Mg++ binding site [ion binding]; other site
1192196005698	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1192196005699	nucleotide binding region [chemical binding]; other site
1192196005700	ATP-binding site [chemical binding]; other site
1192196005701	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1192196005702	Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359
1192196005703	RNase_H superfamily; Region: RNase_H_2; pfam13482
1192196005704	active site
1192196005705	substrate binding site [chemical binding]; other site
1192196005706	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1192196005707	Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122
1192196005708	hypothetical protein; Provisional; Region: PRK13660
1192196005709	cell division protein GpsB; Provisional; Region: PRK14127
1192196005710	DivIVA domain; Region: DivI1A_domain; TIGR03544
1192196005711	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1192196005712	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1192196005713	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
1192196005714	YpzG-like protein; Region: YpzG; pfam14139
1192196005715	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1192196005716	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1192196005717	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1192196005718	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
1192196005719	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1192196005720	NADP binding site [chemical binding]; other site
1192196005721	homodimer interface [polypeptide binding]; other site
1192196005722	active site
1192196005723	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
1192196005724	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1192196005725	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1192196005726	DNA binding site [nucleotide binding]
1192196005727	domain linker motif; other site
1192196005728	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
1192196005729	putative dimerization interface [polypeptide binding]; other site
1192196005730	putative ligand binding site [chemical binding]; other site
1192196005731	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1192196005732	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1192196005733	substrate binding site [chemical binding]; other site
1192196005734	ATP binding site [chemical binding]; other site
1192196005735	Entner-Doudoroff aldolase; Region: eda; TIGR01182
1192196005736	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1192196005737	active site
1192196005738	intersubunit interface [polypeptide binding]; other site
1192196005739	catalytic residue [active]
1192196005740	2-keto-3-deoxygluconate permease; Region: KdgT; cl14653
1192196005741	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
1192196005742	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
1192196005743	active site
1192196005744	Zn binding site [ion binding]; other site
1192196005745	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1192196005746	active site
1192196005747	xanthine permease; Region: pbuX; TIGR03173
1192196005748	Microtubule-associated protein CRIPT; Region: Cript; pfam10235
1192196005749	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
1192196005750	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1192196005751	malonyl-CoA binding site [chemical binding]; other site
1192196005752	dimer interface [polypeptide binding]; other site
1192196005753	active site
1192196005754	product binding site; other site
1192196005755	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
1192196005756	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1192196005757	Dynamin family; Region: Dynamin_N; pfam00350
1192196005758	G1 box; other site
1192196005759	GTP/Mg2+ binding site [chemical binding]; other site
1192196005760	G2 box; other site
1192196005761	Switch I region; other site
1192196005762	G3 box; other site
1192196005763	Switch II region; other site
1192196005764	G4 box; other site
1192196005765	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1192196005766	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1192196005767	G1 box; other site
1192196005768	GTP/Mg2+ binding site [chemical binding]; other site
1192196005769	Dynamin family; Region: Dynamin_N; pfam00350
1192196005770	G2 box; other site
1192196005771	Switch I region; other site
1192196005772	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1192196005773	G3 box; other site
1192196005774	Switch II region; other site
1192196005775	GTP/Mg2+ binding site [chemical binding]; other site
1192196005776	G4 box; other site
1192196005777	G5 box; other site
1192196005778	Protein of unknown function (DUF2533); Region: DUF2533; pfam10752
1192196005779	5'-3' exonuclease; Region: 53EXOc; smart00475
1192196005780	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1192196005781	active site
1192196005782	metal binding site 1 [ion binding]; metal-binding site
1192196005783	putative 5' ssDNA interaction site; other site
1192196005784	metal binding site 3; metal-binding site
1192196005785	metal binding site 2 [ion binding]; metal-binding site
1192196005786	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1192196005787	putative DNA binding site [nucleotide binding]; other site
1192196005788	putative metal binding site [ion binding]; other site
1192196005789	small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093
1192196005790	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1192196005791	RNA/DNA hybrid binding site [nucleotide binding]; other site
1192196005792	active site
1192196005793	conserved hypothetical integral membrane protein; Region: TIGR00697
1192196005794	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1192196005795	RNA/DNA hybrid binding site [nucleotide binding]; other site
1192196005796	active site
1192196005797	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
1192196005798	Protein of unknown function (DUF2564); Region: DUF2564; pfam10819
1192196005799	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1192196005800	DNA-binding site [nucleotide binding]; DNA binding site
1192196005801	RNA-binding motif; other site
1192196005802	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
1192196005803	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1192196005804	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1192196005805	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1192196005806	proposed active site lysine [active]
1192196005807	conserved cys residue [active]
1192196005808	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1192196005809	catalytic residues [active]
1192196005810	dimer interface [polypeptide binding]; other site
1192196005811	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1192196005812	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1192196005813	Zn2+ binding site [ion binding]; other site
1192196005814	Mg2+ binding site [ion binding]; other site
1192196005815	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
1192196005816	Virulence factor; Region: Virulence_fact; pfam13769
1192196005817	HEAT repeats; Region: HEAT_2; pfam13646
1192196005818	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
1192196005819	HEAT repeats; Region: HEAT_2; pfam13646
1192196005820	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
1192196005821	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1192196005822	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1192196005823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196005824	S-adenosylmethionine binding site [chemical binding]; other site
1192196005825	YpjP-like protein; Region: YpjP; pfam14005
1192196005826	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1192196005827	tetramer interfaces [polypeptide binding]; other site
1192196005828	binuclear metal-binding site [ion binding]; other site
1192196005829	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1192196005830	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1192196005831	dimerization interface [polypeptide binding]; other site
1192196005832	active site
1192196005833	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1192196005834	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1192196005835	folate binding site [chemical binding]; other site
1192196005836	NADP+ binding site [chemical binding]; other site
1192196005837	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1192196005838	putative acyl-acceptor binding pocket; other site
1192196005839	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1192196005840	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1192196005841	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196005842	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1192196005843	Walker A motif; other site
1192196005844	ATP binding site [chemical binding]; other site
1192196005845	Walker B motif; other site
1192196005846	arginine finger; other site
1192196005847	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
1192196005848	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1192196005849	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196005850	catalytic residue [active]
1192196005851	Protein of unknown function (DUF2535); Region: DUF2535; pfam10751
1192196005852	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1192196005853	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1192196005854	Cu(I) binding site [ion binding]; other site
1192196005855	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
1192196005856	active site
1192196005857	catalytic triad [active]
1192196005858	oxyanion hole [active]
1192196005859	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698
1192196005860	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1192196005861	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1192196005862	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196005863	MarR family; Region: MarR; pfam01047
1192196005864	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1192196005865	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1192196005866	SelR domain; Region: SelR; pfam01641
1192196005867	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1192196005868	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1192196005869	active site
1192196005870	Phytase; Region: Phytase; cl17685
1192196005871	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
1192196005872	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
1192196005873	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1192196005874	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1192196005875	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1192196005876	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1192196005877	active site
1192196005878	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196005879	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1192196005880	Coenzyme A binding pocket [chemical binding]; other site
1192196005881	hypothetical protein; Provisional; Region: PRK06917
1192196005882	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1192196005883	inhibitor-cofactor binding pocket; inhibition site
1192196005884	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196005885	catalytic residue [active]
1192196005886	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1192196005887	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1192196005888	acetylornithine deacetylase; Validated; Region: PRK06915
1192196005889	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
1192196005890	metal binding site [ion binding]; metal-binding site
1192196005891	dimer interface [polypeptide binding]; other site
1192196005892	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
1192196005893	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196005894	Coenzyme A binding pocket [chemical binding]; other site
1192196005895	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
1192196005896	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196005897	FeS/SAM binding site; other site
1192196005898	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
1192196005899	hypothetical protein; Provisional; Region: PRK13672
1192196005900	YozD-like protein; Region: YozD; pfam14162
1192196005901	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1192196005902	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1192196005903	active site
1192196005904	YodL-like; Region: YodL; pfam14191
1192196005905	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1192196005906	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1192196005907	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1192196005908	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1192196005909	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1192196005910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196005911	S-adenosylmethionine binding site [chemical binding]; other site
1192196005912	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1192196005913	C-terminal peptidase (prc); Region: prc; TIGR00225
1192196005914	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1192196005915	protein binding site [polypeptide binding]; other site
1192196005916	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1192196005917	Catalytic dyad [active]
1192196005918	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1192196005919	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1192196005920	Na binding site [ion binding]; other site
1192196005921	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1192196005922	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196005923	Zn binding site [ion binding]; other site
1192196005924	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1192196005925	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196005926	Zn binding site [ion binding]; other site
1192196005927	Predicted esterase [General function prediction only]; Region: COG0400
1192196005928	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1192196005929	dimer interface [polypeptide binding]; other site
1192196005930	FMN binding site [chemical binding]; other site
1192196005931	Predicted transcriptional regulators [Transcription]; Region: COG1733
1192196005932	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196005933	dimerization interface [polypeptide binding]; other site
1192196005934	putative DNA binding site [nucleotide binding]; other site
1192196005935	putative Zn2+ binding site [ion binding]; other site
1192196005936	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1192196005937	GntP family permease; Region: GntP_permease; pfam02447
1192196005938	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1192196005939	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
1192196005940	rarD protein; Region: rarD; TIGR00688
1192196005941	EamA-like transporter family; Region: EamA; pfam00892
1192196005942	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
1192196005943	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1192196005944	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1192196005945	multidrug efflux protein; Reviewed; Region: PRK01766
1192196005946	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1192196005947	cation binding site [ion binding]; other site
1192196005948	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1192196005949	Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372
1192196005950	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1192196005951	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1192196005952	glycosyltransferase, MGT family; Region: MGT; TIGR01426
1192196005953	active site
1192196005954	TDP-binding site; other site
1192196005955	acceptor substrate-binding pocket; other site
1192196005956	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196005957	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196005958	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196005959	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196005960	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1192196005961	NlpC/P60 family; Region: NLPC_P60; pfam00877
1192196005962	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1192196005963	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1192196005964	E-class dimer interface [polypeptide binding]; other site
1192196005965	P-class dimer interface [polypeptide binding]; other site
1192196005966	active site
1192196005967	Cu2+ binding site [ion binding]; other site
1192196005968	Zn2+ binding site [ion binding]; other site
1192196005969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196005970	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1192196005971	Walker A motif; other site
1192196005972	ATP binding site [chemical binding]; other site
1192196005973	Walker B motif; other site
1192196005974	arginine finger; other site
1192196005975	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
1192196005976	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
1192196005977	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1192196005978	metal ion-dependent adhesion site (MIDAS); other site
1192196005979	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1192196005980	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1192196005981	TPP-binding site [chemical binding]; other site
1192196005982	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1192196005983	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1192196005984	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1192196005985	E3 interaction surface; other site
1192196005986	lipoyl attachment site [posttranslational modification]; other site
1192196005987	e3 binding domain; Region: E3_binding; pfam02817
1192196005988	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1192196005989	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1192196005990	Sodium Bile acid symporter family; Region: SBF; pfam01758
1192196005991	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1192196005992	Na2 binding site [ion binding]; other site
1192196005993	putative substrate binding site 1 [chemical binding]; other site
1192196005994	Na binding site 1 [ion binding]; other site
1192196005995	putative substrate binding site 2 [chemical binding]; other site
1192196005996	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1192196005997	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1192196005998	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1192196005999	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
1192196006000	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
1192196006001	Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657
1192196006002	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
1192196006003	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1192196006004	NAD(P) binding site [chemical binding]; other site
1192196006005	catalytic residues [active]
1192196006006	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1192196006007	pentamer interface [polypeptide binding]; other site
1192196006008	dodecaamer interface [polypeptide binding]; other site
1192196006009	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1192196006010	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1192196006011	putative dimer interface [polypeptide binding]; other site
1192196006012	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
1192196006013	azoreductase; Provisional; Region: PRK13556
1192196006014	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1192196006015	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196006016	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196006017	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1192196006018	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1192196006019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196006020	active site
1192196006021	phosphorylation site [posttranslational modification]
1192196006022	intermolecular recognition site; other site
1192196006023	dimerization interface [polypeptide binding]; other site
1192196006024	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1192196006025	DNA binding residues [nucleotide binding]
1192196006026	dimerization interface [polypeptide binding]; other site
1192196006027	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1192196006028	Histidine kinase; Region: HisKA_3; pfam07730
1192196006029	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1192196006030	ATP binding site [chemical binding]; other site
1192196006031	Mg2+ binding site [ion binding]; other site
1192196006032	G-X-G motif; other site
1192196006033	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1192196006034	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
1192196006035	putative di-iron ligands [ion binding]; other site
1192196006036	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1192196006037	putative dimer interface [polypeptide binding]; other site
1192196006038	catalytic triad [active]
1192196006039	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1192196006040	Protein required for attachment to host cells; Region: Host_attach; cl02398
1192196006041	Predicted membrane protein [Function unknown]; Region: COG2322
1192196006042	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1192196006043	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1192196006044	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1192196006045	catalytic residue [active]
1192196006046	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196006047	dimerization interface [polypeptide binding]; other site
1192196006048	putative DNA binding site [nucleotide binding]; other site
1192196006049	putative Zn2+ binding site [ion binding]; other site
1192196006050	Predicted transcriptional regulator [Transcription]; Region: COG2378
1192196006051	HTH domain; Region: HTH_11; pfam08279
1192196006052	WYL domain; Region: WYL; pfam13280
1192196006053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1192196006054	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1192196006055	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1192196006056	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196006057	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196006058	WHG domain; Region: WHG; pfam13305
1192196006059	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196006060	Coenzyme A binding pocket [chemical binding]; other site
1192196006061	Cupin domain; Region: Cupin_2; pfam07883
1192196006062	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1192196006063	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1192196006064	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
1192196006065	dimer interface [polypeptide binding]; other site
1192196006066	putative tRNA-binding site [nucleotide binding]; other site
1192196006067	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1192196006068	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1192196006069	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1192196006070	Uncharacterized conserved protein [Function unknown]; Region: COG5444
1192196006071	A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411
1192196006072	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1192196006073	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1192196006074	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1192196006075	nucleotide binding site [chemical binding]; other site
1192196006076	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1192196006077	Melibiase; Region: Melibiase; pfam02065
1192196006078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196006079	dimer interface [polypeptide binding]; other site
1192196006080	conserved gate region; other site
1192196006081	putative PBP binding loops; other site
1192196006082	ABC-ATPase subunit interface; other site
1192196006083	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1192196006084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196006085	dimer interface [polypeptide binding]; other site
1192196006086	conserved gate region; other site
1192196006087	putative PBP binding loops; other site
1192196006088	ABC-ATPase subunit interface; other site
1192196006089	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1192196006090	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1192196006091	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1192196006092	beta-galactosidase; Region: BGL; TIGR03356
1192196006093	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1192196006094	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1192196006095	DNA binding site [nucleotide binding]
1192196006096	domain linker motif; other site
1192196006097	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277
1192196006098	putative dimerization interface [polypeptide binding]; other site
1192196006099	putative ligand binding site [chemical binding]; other site
1192196006100	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1192196006101	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
1192196006102	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1192196006103	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1192196006104	non-specific DNA binding site [nucleotide binding]; other site
1192196006105	salt bridge; other site
1192196006106	sequence-specific DNA binding site [nucleotide binding]; other site
1192196006107	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
1192196006108	phosphoenolpyruvate synthase; Validated; Region: PRK06241
1192196006109	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1192196006110	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1192196006111	Protein of unknown function (DUF3221); Region: DUF3221; pfam11518
1192196006112	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1192196006113	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1192196006114	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
1192196006115	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1192196006116	conserved cys residue [active]
1192196006117	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1192196006118	EamA-like transporter family; Region: EamA; pfam00892
1192196006119	EamA-like transporter family; Region: EamA; pfam00892
1192196006120	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196006121	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196006122	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1192196006123	dimerization interface [polypeptide binding]; other site
1192196006124	Uncharacterized integral membrane protein [Function unknown]; Region: COG3739
1192196006125	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1192196006126	salt bridge; other site
1192196006127	non-specific DNA binding site [nucleotide binding]; other site
1192196006128	sequence-specific DNA binding site [nucleotide binding]; other site
1192196006129	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
1192196006130	VanW like protein; Region: VanW; pfam04294
1192196006131	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1192196006132	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196006133	Coenzyme A binding pocket [chemical binding]; other site
1192196006134	YoaP-like; Region: YoaP; pfam14268
1192196006135	Cupin; Region: Cupin_1; smart00835
1192196006136	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1192196006137	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1192196006138	Amb_all domain; Region: Amb_all; smart00656
1192196006139	Predicted membrane protein [Function unknown]; Region: COG3619
1192196006140	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
1192196006141	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1192196006142	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
1192196006143	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
1192196006144	CHASE3 domain; Region: CHASE3; cl05000
1192196006145	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196006146	dimerization interface [polypeptide binding]; other site
1192196006147	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1192196006148	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1192196006149	dimer interface [polypeptide binding]; other site
1192196006150	putative CheW interface [polypeptide binding]; other site
1192196006151	Protein of unknown function (DUF4025); Region: DUF4025; pfam13217
1192196006152	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1192196006153	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
1192196006154	putative [4Fe-4S] binding site [ion binding]; other site
1192196006155	putative molybdopterin cofactor binding site [chemical binding]; other site
1192196006156	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
1192196006157	putative molybdopterin cofactor binding site; other site
1192196006158	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1192196006159	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
1192196006160	putative ligand binding site [chemical binding]; other site
1192196006161	putative NAD binding site [chemical binding]; other site
1192196006162	catalytic site [active]
1192196006163	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1192196006164	Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798
1192196006165	putative N- and C-terminal domain interface [polypeptide binding]; other site
1192196006166	putative active site [active]
1192196006167	putative MgATP binding site [chemical binding]; other site
1192196006168	catalytic site [active]
1192196006169	metal binding site [ion binding]; metal-binding site
1192196006170	carbohydrate binding site [chemical binding]; other site
1192196006171	polyol permease family; Region: 2A0118; TIGR00897
1192196006172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196006173	putative substrate translocation pore; other site
1192196006174	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196006175	MarR family; Region: MarR_2; pfam12802
1192196006176	MarR family; Region: MarR_2; cl17246
1192196006177	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1192196006178	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196006179	Walker A/P-loop; other site
1192196006180	ATP binding site [chemical binding]; other site
1192196006181	Q-loop/lid; other site
1192196006182	ABC transporter signature motif; other site
1192196006183	Walker B; other site
1192196006184	D-loop; other site
1192196006185	H-loop/switch region; other site
1192196006186	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1192196006187	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1192196006188	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1192196006189	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1192196006190	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
1192196006191	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
1192196006192	classical (c) SDRs; Region: SDR_c; cd05233
1192196006193	NAD(P) binding site [chemical binding]; other site
1192196006194	active site
1192196006195	Replication terminator protein; Region: RTP; pfam02334
1192196006196	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1192196006197	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
1192196006198	gamma-glutamyl kinase; Provisional; Region: PRK13402
1192196006199	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1192196006200	nucleotide binding site [chemical binding]; other site
1192196006201	homotetrameric interface [polypeptide binding]; other site
1192196006202	putative phosphate binding site [ion binding]; other site
1192196006203	putative allosteric binding site; other site
1192196006204	PUA domain; Region: PUA; pfam01472
1192196006205	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196006206	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196006207	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1192196006208	putative dimerization interface [polypeptide binding]; other site
1192196006209	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1192196006210	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1192196006211	active site
1192196006212	dimer interface [polypeptide binding]; other site
1192196006213	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1192196006214	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1192196006215	active site
1192196006216	FMN binding site [chemical binding]; other site
1192196006217	substrate binding site [chemical binding]; other site
1192196006218	3Fe-4S cluster binding site [ion binding]; other site
1192196006219	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1192196006220	domain interface; other site
1192196006221	glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317
1192196006222	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1192196006223	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1192196006224	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1192196006225	NAD(P) binding site [chemical binding]; other site
1192196006226	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196006227	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196006228	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1192196006229	putative dimerization interface [polypeptide binding]; other site
1192196006230	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1192196006231	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
1192196006232	Helix-turn-helix domain; Region: HTH_17; cl17695
1192196006233	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1192196006234	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1192196006235	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1192196006236	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
1192196006237	active site
1192196006238	catalytic residues [active]
1192196006239	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113
1192196006240	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1192196006241	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1192196006242	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1192196006243	acyl-activating enzyme (AAE) consensus motif; other site
1192196006244	AMP binding site [chemical binding]; other site
1192196006245	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1192196006246	Condensation domain; Region: Condensation; pfam00668
1192196006247	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1192196006248	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1192196006249	acyl-activating enzyme (AAE) consensus motif; other site
1192196006250	AMP binding site [chemical binding]; other site
1192196006251	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006252	Condensation domain; Region: Condensation; pfam00668
1192196006253	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1192196006254	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1192196006255	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1192196006256	acyl-activating enzyme (AAE) consensus motif; other site
1192196006257	AMP binding site [chemical binding]; other site
1192196006258	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006259	Condensation domain; Region: Condensation; pfam00668
1192196006260	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1192196006261	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1192196006262	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1192196006263	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1192196006264	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1192196006265	acyl-activating enzyme (AAE) consensus motif; other site
1192196006266	AMP binding site [chemical binding]; other site
1192196006267	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006268	Condensation domain; Region: Condensation; pfam00668
1192196006269	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1192196006270	Condensation domain; Region: Condensation; pfam00668
1192196006271	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1192196006272	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1192196006273	acyl-activating enzyme (AAE) consensus motif; other site
1192196006274	AMP binding site [chemical binding]; other site
1192196006275	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006276	Condensation domain; Region: Condensation; pfam00668
1192196006277	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1192196006278	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1192196006279	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1192196006280	acyl-activating enzyme (AAE) consensus motif; other site
1192196006281	AMP binding site [chemical binding]; other site
1192196006282	Condensation domain; Region: Condensation; pfam00668
1192196006283	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1192196006284	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1192196006285	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1192196006286	acyl-activating enzyme (AAE) consensus motif; other site
1192196006287	AMP binding site [chemical binding]; other site
1192196006288	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006289	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1192196006290	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
1192196006291	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
1192196006292	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1192196006293	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1192196006294	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1192196006295	active site
1192196006296	AMP-binding domain protein; Validated; Region: PRK08315
1192196006297	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1192196006298	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1192196006299	acyl-activating enzyme (AAE) consensus motif; other site
1192196006300	putative AMP binding site [chemical binding]; other site
1192196006301	putative active site [active]
1192196006302	putative CoA binding site [chemical binding]; other site
1192196006303	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
1192196006304	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1192196006305	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1192196006306	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1192196006307	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1192196006308	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1192196006309	active site
1192196006310	catalytic residues [active]
1192196006311	metal binding site [ion binding]; metal-binding site
1192196006312	enoyl-CoA hydratase; Provisional; Region: PRK07657
1192196006313	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1192196006314	substrate binding site [chemical binding]; other site
1192196006315	oxyanion hole (OAH) forming residues; other site
1192196006316	trimer interface [polypeptide binding]; other site
1192196006317	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1192196006318	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1192196006319	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1192196006320	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
1192196006321	DHH family; Region: DHH; pfam01368
1192196006322	DHHA1 domain; Region: DHHA1; pfam02272
1192196006323	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1192196006324	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1192196006325	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1192196006326	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1192196006327	active site
1192196006328	tetramer interface; other site
1192196006329	Predicted membrane protein [Function unknown]; Region: COG2246
1192196006330	GtrA-like protein; Region: GtrA; pfam04138
1192196006331	Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003
1192196006332	substrate binding site [chemical binding]; other site
1192196006333	active site
1192196006334	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
1192196006335	metal binding site [ion binding]; metal-binding site
1192196006336	ligand binding site [chemical binding]; other site
1192196006337	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
1192196006338	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
1192196006339	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
1192196006340	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1192196006341	Cellulose binding domain; Region: CBM_3; pfam00942
1192196006342	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1192196006343	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
1192196006344	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
1192196006345	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1192196006346	CAP-like domain; other site
1192196006347	active site
1192196006348	primary dimer interface [polypeptide binding]; other site
1192196006349	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1192196006350	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1192196006351	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1192196006352	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1192196006353	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
1192196006354	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196006355	ATP binding site [chemical binding]; other site
1192196006356	Mg2+ binding site [ion binding]; other site
1192196006357	G-X-G motif; other site
1192196006358	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1192196006359	anchoring element; other site
1192196006360	dimer interface [polypeptide binding]; other site
1192196006361	ATP binding site [chemical binding]; other site
1192196006362	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1192196006363	active site
1192196006364	putative metal-binding site [ion binding]; other site
1192196006365	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1192196006366	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1192196006367	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1192196006368	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
1192196006369	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1192196006370	active site
1192196006371	small acid-soluble spore protein Tlp; Provisional; Region: PRK03830
1192196006372	acid-soluble spore protein N; Provisional; Region: sspN; PRK09398
1192196006373	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1192196006374	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1192196006375	catalytic residues [active]
1192196006376	aconitate hydratase; Validated; Region: PRK09277
1192196006377	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1192196006378	substrate binding site [chemical binding]; other site
1192196006379	ligand binding site [chemical binding]; other site
1192196006380	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1192196006381	substrate binding site [chemical binding]; other site
1192196006382	acid-soluble spore protein O; Provisional; Region: sspO; PRK02984
1192196006383	acid-soluble spore protein P; Provisional; Region: sspP; PRK09399
1192196006384	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1192196006385	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1192196006386	putative dimer interface [polypeptide binding]; other site
1192196006387	Protein of unknown function (DUF2621); Region: DUF2621; pfam11084
1192196006388	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
1192196006389	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1192196006390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196006391	active site
1192196006392	phosphorylation site [posttranslational modification]
1192196006393	intermolecular recognition site; other site
1192196006394	dimerization interface [polypeptide binding]; other site
1192196006395	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1192196006396	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1192196006397	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1192196006398	hypothetical protein; Provisional; Region: PRK01844
1192196006399	Protein of unknown function (DUF2522); Region: DUF2522; pfam10747
1192196006400	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1192196006401	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1192196006402	TPP-binding site [chemical binding]; other site
1192196006403	dimer interface [polypeptide binding]; other site
1192196006404	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1192196006405	PYR/PP interface [polypeptide binding]; other site
1192196006406	dimer interface [polypeptide binding]; other site
1192196006407	TPP binding site [chemical binding]; other site
1192196006408	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1192196006409	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1192196006410	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1192196006411	catalytic residues [active]
1192196006412	catalytic nucleophile [active]
1192196006413	cell division suppressor protein YneA; Provisional; Region: PRK14125
1192196006414	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196006415	LexA repressor; Validated; Region: PRK00215
1192196006416	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196006417	putative DNA binding site [nucleotide binding]; other site
1192196006418	putative Zn2+ binding site [ion binding]; other site
1192196006419	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1192196006420	Catalytic site [active]
1192196006421	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
1192196006422	FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363
1192196006423	putative active site [active]
1192196006424	putative Mg binding site [ion binding]; other site
1192196006425	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
1192196006426	Phage-related replication protein [General function prediction only]; Region: COG4195
1192196006427	YndJ-like protein; Region: YndJ; pfam14158
1192196006428	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
1192196006429	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1192196006430	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1192196006431	Spore germination protein; Region: Spore_permease; pfam03845
1192196006432	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1192196006433	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1192196006434	putative hydrophobic ligand binding site [chemical binding]; other site
1192196006435	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
1192196006436	Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427
1192196006437	putative binding site; other site
1192196006438	putative dimer interface [polypeptide binding]; other site
1192196006439	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1192196006440	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1192196006441	dimerization interface [polypeptide binding]; other site
1192196006442	active site
1192196006443	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1192196006444	trimer interface [polypeptide binding]; other site
1192196006445	active site
1192196006446	Protein of unknown function (DUF2691); Region: DUF2691; pfam10903
1192196006447	alanine racemase; Region: alr; TIGR00492
1192196006448	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1192196006449	active site
1192196006450	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1192196006451	dimer interface [polypeptide binding]; other site
1192196006452	substrate binding site [chemical binding]; other site
1192196006453	catalytic residues [active]
1192196006454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196006455	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1192196006456	putative substrate translocation pore; other site
1192196006457	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196006458	Staphylococcal nuclease homologues; Region: SNc; smart00318
1192196006459	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1192196006460	Catalytic site; other site
1192196006461	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1192196006462	N- and C-terminal domain interface [polypeptide binding]; other site
1192196006463	D-xylulose kinase; Region: XylB; TIGR01312
1192196006464	active site
1192196006465	MgATP binding site [chemical binding]; other site
1192196006466	catalytic site [active]
1192196006467	metal binding site [ion binding]; metal-binding site
1192196006468	xylulose binding site [chemical binding]; other site
1192196006469	homodimer interface [polypeptide binding]; other site
1192196006470	xylose isomerase; Provisional; Region: PRK05474
1192196006471	xylose isomerase; Region: xylose_isom_A; TIGR02630
1192196006472	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1192196006473	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1192196006474	nucleotide binding site [chemical binding]; other site
1192196006475	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1192196006476	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1192196006477	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1192196006478	inhibitor binding site; inhibition site
1192196006479	active site
1192196006480	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1192196006481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196006482	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
1192196006483	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1192196006484	CAAX protease self-immunity; Region: Abi; pfam02517
1192196006485	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1192196006486	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196006487	Coenzyme A binding pocket [chemical binding]; other site
1192196006488	glutamine synthetase, type I; Region: GlnA; TIGR00653
1192196006489	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1192196006490	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1192196006491	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1192196006492	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1192196006493	DNA binding residues [nucleotide binding]
1192196006494	putative dimer interface [polypeptide binding]; other site
1192196006495	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1192196006496	Aluminium resistance protein; Region: Alum_res; pfam06838
1192196006497	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1192196006498	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1192196006499	HflX GTPase family; Region: HflX; cd01878
1192196006500	G1 box; other site
1192196006501	GTP/Mg2+ binding site [chemical binding]; other site
1192196006502	Switch I region; other site
1192196006503	G2 box; other site
1192196006504	G3 box; other site
1192196006505	Switch II region; other site
1192196006506	G4 box; other site
1192196006507	G5 box; other site
1192196006508	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1192196006509	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196006510	Walker A motif; other site
1192196006511	ATP binding site [chemical binding]; other site
1192196006512	Walker B motif; other site
1192196006513	arginine finger; other site
1192196006514	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1192196006515	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1192196006516	active site
1192196006517	metal binding site [ion binding]; metal-binding site
1192196006518	Sporulation related domain; Region: SPOR; pfam05036
1192196006519	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
1192196006520	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1192196006521	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1192196006522	dimer interface [polypeptide binding]; other site
1192196006523	putative radical transfer pathway; other site
1192196006524	diiron center [ion binding]; other site
1192196006525	tyrosyl radical; other site
1192196006526	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
1192196006527	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1192196006528	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1192196006529	active site
1192196006530	dimer interface [polypeptide binding]; other site
1192196006531	catalytic residues [active]
1192196006532	effector binding site; other site
1192196006533	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1192196006534	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1192196006535	YmzC-like protein; Region: YmzC; pfam14157
1192196006536	bacterial Hfq-like; Region: Hfq; cd01716
1192196006537	hexamer interface [polypeptide binding]; other site
1192196006538	Sm1 motif; other site
1192196006539	RNA binding site [nucleotide binding]; other site
1192196006540	Sm2 motif; other site
1192196006541	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1192196006542	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1192196006543	YmaF family; Region: YmaF; pfam12788
1192196006544	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
1192196006545	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1192196006546	peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563
1192196006547	Phage-related replication protein [General function prediction only]; Region: COG4195
1192196006548	WYL domain; Region: WYL; cl14852
1192196006549	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1192196006550	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
1192196006551	active site
1192196006552	catalytic triad [active]
1192196006553	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1192196006554	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1192196006555	Cytochrome P450; Region: p450; cl12078
1192196006556	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1192196006557	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196006558	S-adenosylmethionine binding site [chemical binding]; other site
1192196006559	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1192196006560	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006561	active site
1192196006562	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1192196006563	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006564	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1192196006565	active site
1192196006566	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1192196006567	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1192196006568	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1192196006569	putative NADP binding site [chemical binding]; other site
1192196006570	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1192196006571	active site
1192196006572	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1192196006573	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1192196006574	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1192196006575	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1192196006576	putative NADP binding site [chemical binding]; other site
1192196006577	active site
1192196006578	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1192196006579	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006580	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1192196006581	active site
1192196006582	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1192196006583	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1192196006584	putative NADP binding site [chemical binding]; other site
1192196006585	active site
1192196006586	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1192196006587	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006588	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1192196006589	active site
1192196006590	Condensation domain; Region: Condensation; pfam00668
1192196006591	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1192196006592	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1192196006593	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1192196006594	acyl-activating enzyme (AAE) consensus motif; other site
1192196006595	AMP binding site [chemical binding]; other site
1192196006596	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006597	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006598	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1192196006599	active site
1192196006600	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1192196006601	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1192196006602	putative NADP binding site [chemical binding]; other site
1192196006603	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1192196006604	active site
1192196006605	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006606	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006607	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1192196006608	active site
1192196006609	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006610	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1192196006611	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006612	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006613	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1192196006614	active site
1192196006615	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1192196006616	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1192196006617	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006618	active site
1192196006619	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1192196006620	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1192196006621	putative NADP binding site [chemical binding]; other site
1192196006622	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1192196006623	active site
1192196006624	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006625	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1192196006626	active site
1192196006627	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1192196006628	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1192196006629	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1192196006630	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006631	active site
1192196006632	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1192196006633	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1192196006634	putative NADP binding site [chemical binding]; other site
1192196006635	active site
1192196006636	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006637	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006638	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1192196006639	active site
1192196006640	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006641	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1192196006642	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006643	active site
1192196006644	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1192196006645	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1192196006646	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1192196006647	putative NADP binding site [chemical binding]; other site
1192196006648	active site
1192196006649	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006650	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1192196006651	The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906
1192196006652	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1192196006653	acyl-activating enzyme (AAE) consensus motif; other site
1192196006654	putative AMP binding site [chemical binding]; other site
1192196006655	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006656	Condensation domain; Region: Condensation; pfam00668
1192196006657	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1192196006658	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1192196006659	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
1192196006660	acyl-activating enzyme (AAE) consensus motif; other site
1192196006661	AMP binding site [chemical binding]; other site
1192196006662	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006663	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1192196006664	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006665	active site
1192196006666	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1192196006667	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1192196006668	KR domain; Region: KR; pfam08659
1192196006669	putative NADP binding site [chemical binding]; other site
1192196006670	active site
1192196006671	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006672	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006673	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1192196006674	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006675	active site
1192196006676	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1192196006677	putative NADP binding site [chemical binding]; other site
1192196006678	active site
1192196006679	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196006680	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1192196006681	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1192196006682	active site
1192196006683	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1192196006684	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1192196006685	substrate binding site [chemical binding]; other site
1192196006686	oxyanion hole (OAH) forming residues; other site
1192196006687	trimer interface [polypeptide binding]; other site
1192196006688	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1192196006689	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1192196006690	substrate binding site [chemical binding]; other site
1192196006691	oxyanion hole (OAH) forming residues; other site
1192196006692	trimer interface [polypeptide binding]; other site
1192196006693	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
1192196006694	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1192196006695	dimer interface [polypeptide binding]; other site
1192196006696	active site
1192196006697	polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103
1192196006698	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1192196006699	dimer interface [polypeptide binding]; other site
1192196006700	active site
1192196006701	acyl carrier protein; Validated; Region: PRK07117
1192196006702	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1192196006703	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1192196006704	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
1192196006705	FMN binding site [chemical binding]; other site
1192196006706	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1192196006707	substrate binding site [chemical binding]; other site
1192196006708	putative catalytic residue [active]
1192196006709	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1192196006710	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1192196006711	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1192196006712	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1192196006713	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1192196006714	transcriptional regulator BetI; Validated; Region: PRK00767
1192196006715	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196006716	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1192196006717	Regulatory protein YrvL; Region: YrvL; pfam14184
1192196006718	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1192196006719	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196006720	ATP binding site [chemical binding]; other site
1192196006721	Mg2+ binding site [ion binding]; other site
1192196006722	G-X-G motif; other site
1192196006723	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1192196006724	ATP binding site [chemical binding]; other site
1192196006725	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1192196006726	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1192196006727	MutS domain I; Region: MutS_I; pfam01624
1192196006728	MutS domain II; Region: MutS_II; pfam05188
1192196006729	MutS domain III; Region: MutS_III; pfam05192
1192196006730	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1192196006731	Walker A/P-loop; other site
1192196006732	ATP binding site [chemical binding]; other site
1192196006733	Q-loop/lid; other site
1192196006734	ABC transporter signature motif; other site
1192196006735	Walker B; other site
1192196006736	D-loop; other site
1192196006737	H-loop/switch region; other site
1192196006738	Outer spore coat protein E (CotE); Region: CotE; pfam10628
1192196006739	Predicted membrane protein [Function unknown]; Region: COG4550
1192196006740	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
1192196006741	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1192196006742	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196006743	FeS/SAM binding site; other site
1192196006744	TRAM domain; Region: TRAM; pfam01938
1192196006745	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1192196006746	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1192196006747	substrate-cofactor binding pocket; other site
1192196006748	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196006749	catalytic residue [active]
1192196006750	Threonine dehydrogenase; Region: TDH; cd05281
1192196006751	L-threonine 3-dehydrogenase; Region: tdh; TIGR00692
1192196006752	structural Zn binding site [ion binding]; other site
1192196006753	catalytic Zn binding site [ion binding]; other site
1192196006754	tetramer interface [polypeptide binding]; other site
1192196006755	NADP binding site [chemical binding]; other site
1192196006756	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
1192196006757	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1192196006758	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1192196006759	putative active site [active]
1192196006760	metal binding site [ion binding]; metal-binding site
1192196006761	homodimer binding site [polypeptide binding]; other site
1192196006762	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
1192196006763	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1192196006764	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1192196006765	Zn2+ binding site [ion binding]; other site
1192196006766	Mg2+ binding site [ion binding]; other site
1192196006767	Beta-lactamase; Region: Beta-lactamase; pfam00144
1192196006768	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1192196006769	recombinase A; Provisional; Region: recA; PRK09354
1192196006770	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1192196006771	hexamer interface [polypeptide binding]; other site
1192196006772	Walker A motif; other site
1192196006773	ATP binding site [chemical binding]; other site
1192196006774	Walker B motif; other site
1192196006775	competence damage-inducible protein A; Provisional; Region: PRK00549
1192196006776	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1192196006777	putative MPT binding site; other site
1192196006778	competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199
1192196006779	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1192196006780	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1192196006781	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1192196006782	non-specific DNA binding site [nucleotide binding]; other site
1192196006783	salt bridge; other site
1192196006784	sequence-specific DNA binding site [nucleotide binding]; other site
1192196006785	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1192196006786	ACT domain; Region: ACT; pfam01842
1192196006787	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
1192196006788	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
1192196006789	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1192196006790	classical (c) SDRs; Region: SDR_c; cd05233
1192196006791	NAD(P) binding site [chemical binding]; other site
1192196006792	active site
1192196006793	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1192196006794	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1192196006795	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1192196006796	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1192196006797	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1192196006798	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196006799	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196006800	putative substrate translocation pore; other site
1192196006801	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1192196006802	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196006803	DNA-binding site [nucleotide binding]; DNA binding site
1192196006804	UTRA domain; Region: UTRA; pfam07702
1192196006805	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1192196006806	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1192196006807	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1192196006808	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1192196006809	Clp protease; Region: CLP_protease; pfam00574
1192196006810	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
1192196006811	active site
1192196006812	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1192196006813	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1192196006814	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1192196006815	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1192196006816	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1192196006817	dimer interface [polypeptide binding]; other site
1192196006818	active site
1192196006819	catalytic residue [active]
1192196006820	aspartate kinase I; Reviewed; Region: PRK08210
1192196006821	AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of  the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260
1192196006822	putative catalytic residues [active]
1192196006823	putative nucleotide binding site [chemical binding]; other site
1192196006824	putative aspartate binding site [chemical binding]; other site
1192196006825	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
1192196006826	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
1192196006827	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1192196006828	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1192196006829	Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452
1192196006830	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
1192196006831	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
1192196006832	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1192196006833	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
1192196006834	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1192196006835	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1192196006836	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1192196006837	probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873
1192196006838	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
1192196006839	NodB motif; other site
1192196006840	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1192196006841	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1192196006842	RNase E interface [polypeptide binding]; other site
1192196006843	trimer interface [polypeptide binding]; other site
1192196006844	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1192196006845	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1192196006846	RNase E interface [polypeptide binding]; other site
1192196006847	trimer interface [polypeptide binding]; other site
1192196006848	active site
1192196006849	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1192196006850	putative nucleic acid binding region [nucleotide binding]; other site
1192196006851	G-X-X-G motif; other site
1192196006852	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1192196006853	RNA binding site [nucleotide binding]; other site
1192196006854	domain interface; other site
1192196006855	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1192196006856	16S/18S rRNA binding site [nucleotide binding]; other site
1192196006857	S13e-L30e interaction site [polypeptide binding]; other site
1192196006858	25S rRNA binding site [nucleotide binding]; other site
1192196006859	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1192196006860	riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083
1192196006861	active site
1192196006862	Riboflavin kinase; Region: Flavokinase; smart00904
1192196006863	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
1192196006864	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1192196006865	RNA binding site [nucleotide binding]; other site
1192196006866	active site
1192196006867	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1192196006868	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550
1192196006869	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1192196006870	translation initiation factor IF-2; Region: IF-2; TIGR00487
1192196006871	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1192196006872	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1192196006873	G1 box; other site
1192196006874	putative GEF interaction site [polypeptide binding]; other site
1192196006875	GTP/Mg2+ binding site [chemical binding]; other site
1192196006876	Switch I region; other site
1192196006877	G2 box; other site
1192196006878	G3 box; other site
1192196006879	Switch II region; other site
1192196006880	G4 box; other site
1192196006881	G5 box; other site
1192196006882	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1192196006883	Translation-initiation factor 2; Region: IF-2; pfam11987
1192196006884	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1192196006885	hypothetical protein; Provisional; Region: PRK07714
1192196006886	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1192196006887	putative RNA binding cleft [nucleotide binding]; other site
1192196006888	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1192196006889	NusA N-terminal domain; Region: NusA_N; pfam08529
1192196006890	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1192196006891	RNA binding site [nucleotide binding]; other site
1192196006892	homodimer interface [polypeptide binding]; other site
1192196006893	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1192196006894	G-X-X-G motif; other site
1192196006895	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1192196006896	G-X-X-G motif; other site
1192196006897	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1192196006898	Sm and related proteins; Region: Sm_like; cl00259
1192196006899	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1192196006900	putative oligomer interface [polypeptide binding]; other site
1192196006901	putative RNA binding site [nucleotide binding]; other site
1192196006902	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1192196006903	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1192196006904	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1192196006905	generic binding surface II; other site
1192196006906	generic binding surface I; other site
1192196006907	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1192196006908	active site
1192196006909	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1192196006910	active site
1192196006911	catalytic site [active]
1192196006912	substrate binding site [chemical binding]; other site
1192196006913	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1192196006914	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1192196006915	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1192196006916	dimer interface [polypeptide binding]; other site
1192196006917	motif 1; other site
1192196006918	active site
1192196006919	motif 2; other site
1192196006920	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1192196006921	putative deacylase active site [active]
1192196006922	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1192196006923	active site
1192196006924	motif 3; other site
1192196006925	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1192196006926	anticodon binding site; other site
1192196006927	RIP metalloprotease RseP; Region: TIGR00054
1192196006928	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1192196006929	active site
1192196006930	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1192196006931	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1192196006932	protein binding site [polypeptide binding]; other site
1192196006933	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1192196006934	putative substrate binding region [chemical binding]; other site
1192196006935	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1192196006936	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1192196006937	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1192196006938	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1192196006939	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1192196006940	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1192196006941	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1192196006942	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1192196006943	catalytic residue [active]
1192196006944	putative FPP diphosphate  binding site; other site
1192196006945	putative FPP binding hydrophobic cleft; other site
1192196006946	dimer interface [polypeptide binding]; other site
1192196006947	putative IPP diphosphate binding site; other site
1192196006948	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1192196006949	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1192196006950	hinge region; other site
1192196006951	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1192196006952	putative nucleotide binding site [chemical binding]; other site
1192196006953	uridine monophosphate binding site [chemical binding]; other site
1192196006954	homohexameric interface [polypeptide binding]; other site
1192196006955	elongation factor Ts; Provisional; Region: tsf; PRK09377
1192196006956	UBA/TS-N domain; Region: UBA; pfam00627
1192196006957	Elongation factor TS; Region: EF_TS; pfam00889
1192196006958	Elongation factor TS; Region: EF_TS; pfam00889
1192196006959	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1192196006960	rRNA interaction site [nucleotide binding]; other site
1192196006961	S8 interaction site; other site
1192196006962	putative laminin-1 binding site; other site
1192196006963	RNA polymerase sigma factor SigD; Validated; Region: PRK07670
1192196006964	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196006965	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1192196006966	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196006967	DNA binding residues [nucleotide binding]
1192196006968	Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871
1192196006969	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1192196006970	CheC-like family; Region: CheC; pfam04509
1192196006971	CheC-like family; Region: CheC; pfam04509
1192196006972	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1192196006973	putative CheA interaction surface; other site
1192196006974	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196006975	ATP binding site [chemical binding]; other site
1192196006976	G-X-G motif; other site
1192196006977	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1192196006978	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1192196006979	putative binding surface; other site
1192196006980	active site
1192196006981	P2 response regulator binding domain; Region: P2; pfam07194
1192196006982	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1192196006983	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1192196006984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196006985	active site
1192196006986	phosphorylation site [posttranslational modification]
1192196006987	intermolecular recognition site; other site
1192196006988	dimerization interface [polypeptide binding]; other site
1192196006989	CheB methylesterase; Region: CheB_methylest; pfam01339
1192196006990	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1192196006991	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1192196006992	P-loop; other site
1192196006993	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1192196006994	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
1192196006995	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1192196006996	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1192196006997	FHIPEP family; Region: FHIPEP; pfam00771
1192196006998	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1192196006999	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1192196007000	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1192196007001	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1192196007002	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1192196007003	flagella biosynthesis protein FliZ; Provisional; Region: PRK13415
1192196007004	Response regulator receiver domain; Region: Response_reg; pfam00072
1192196007005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196007006	active site
1192196007007	phosphorylation site [posttranslational modification]
1192196007008	intermolecular recognition site; other site
1192196007009	dimerization interface [polypeptide binding]; other site
1192196007010	flagellar motor switch protein; Validated; Region: PRK08119
1192196007011	CheC-like family; Region: CheC; pfam04509
1192196007012	CheC-like family; Region: CheC; pfam04509
1192196007013	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
1192196007014	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1192196007015	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1192196007016	Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580
1192196007017	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718
1192196007018	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
1192196007019	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1192196007020	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1192196007021	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
1192196007022	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1192196007023	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
1192196007024	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1192196007025	Uncharacterized conserved protein [Function unknown]; Region: COG3334
1192196007026	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
1192196007027	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720
1192196007028	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721
1192196007029	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1192196007030	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1192196007031	Walker A motif/ATP binding site; other site
1192196007032	Walker B motif; other site
1192196007033	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
1192196007034	Flagellar assembly protein FliH; Region: FliH; pfam02108
1192196007035	flagellar motor switch protein FliG; Region: fliG; TIGR00207
1192196007036	MgtE intracellular N domain; Region: MgtE_N; smart00924
1192196007037	FliG C-terminal domain; Region: FliG_C; pfam01706
1192196007038	flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206
1192196007039	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
1192196007040	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1192196007041	flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728
1192196007042	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1192196007043	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1192196007044	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1192196007045	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
1192196007046	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1192196007047	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1192196007048	transcriptional repressor CodY; Validated; Region: PRK04158
1192196007049	CodY GAF-like domain; Region: CodY; pfam06018
1192196007050	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
1192196007051	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1192196007052	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196007053	Walker A motif; other site
1192196007054	ATP binding site [chemical binding]; other site
1192196007055	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1192196007056	Walker B motif; other site
1192196007057	arginine finger; other site
1192196007058	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1192196007059	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1192196007060	active site
1192196007061	HslU subunit interaction site [polypeptide binding]; other site
1192196007062	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1192196007063	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1192196007064	active site
1192196007065	Int/Topo IB signature motif; other site
1192196007066	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1192196007067	Glucose inhibited division protein A; Region: GIDA; pfam01134
1192196007068	DNA topoisomerase I; Validated; Region: PRK05582
1192196007069	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1192196007070	active site
1192196007071	interdomain interaction site; other site
1192196007072	putative metal-binding site [ion binding]; other site
1192196007073	nucleotide binding site [chemical binding]; other site
1192196007074	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1192196007075	domain I; other site
1192196007076	DNA binding groove [nucleotide binding]
1192196007077	phosphate binding site [ion binding]; other site
1192196007078	domain II; other site
1192196007079	domain III; other site
1192196007080	nucleotide binding site [chemical binding]; other site
1192196007081	catalytic site [active]
1192196007082	domain IV; other site
1192196007083	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1192196007084	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1192196007085	DNA protecting protein DprA; Region: dprA; TIGR00732
1192196007086	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1192196007087	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1192196007088	CoA binding domain; Region: CoA_binding; smart00881
1192196007089	CoA-ligase; Region: Ligase_CoA; pfam00549
1192196007090	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1192196007091	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1192196007092	CoA-ligase; Region: Ligase_CoA; pfam00549
1192196007093	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1192196007094	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1192196007095	RNA/DNA hybrid binding site [nucleotide binding]; other site
1192196007096	active site
1192196007097	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1192196007098	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1192196007099	GTP/Mg2+ binding site [chemical binding]; other site
1192196007100	G4 box; other site
1192196007101	G5 box; other site
1192196007102	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1192196007103	G1 box; other site
1192196007104	G1 box; other site
1192196007105	GTP/Mg2+ binding site [chemical binding]; other site
1192196007106	Switch I region; other site
1192196007107	G2 box; other site
1192196007108	G2 box; other site
1192196007109	G3 box; other site
1192196007110	G3 box; other site
1192196007111	Switch II region; other site
1192196007112	Switch II region; other site
1192196007113	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1192196007114	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1192196007115	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1192196007116	RimM N-terminal domain; Region: RimM; pfam01782
1192196007117	PRC-barrel domain; Region: PRC; pfam05239
1192196007118	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
1192196007119	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1192196007120	KH domain; Region: KH_4; pfam13083
1192196007121	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1192196007122	signal recognition particle protein; Provisional; Region: PRK10867
1192196007123	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1192196007124	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1192196007125	P loop; other site
1192196007126	GTP binding site [chemical binding]; other site
1192196007127	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1192196007128	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1192196007129	putative DNA-binding protein; Validated; Region: PRK00118
1192196007130	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
1192196007131	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1192196007132	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1192196007133	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1192196007134	GTP binding site [chemical binding]; other site
1192196007135	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1192196007136	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1192196007137	Walker A/P-loop; other site
1192196007138	ATP binding site [chemical binding]; other site
1192196007139	Q-loop/lid; other site
1192196007140	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1192196007141	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1192196007142	ABC transporter signature motif; other site
1192196007143	Walker B; other site
1192196007144	D-loop; other site
1192196007145	H-loop/switch region; other site
1192196007146	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
1192196007147	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1192196007148	dimerization interface [polypeptide binding]; other site
1192196007149	active site
1192196007150	metal binding site [ion binding]; metal-binding site
1192196007151	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1192196007152	dsRNA binding site [nucleotide binding]; other site
1192196007153	acyl carrier protein; Provisional; Region: acpP; PRK00982
1192196007154	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1192196007155	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1192196007156	NAD(P) binding site [chemical binding]; other site
1192196007157	homotetramer interface [polypeptide binding]; other site
1192196007158	homodimer interface [polypeptide binding]; other site
1192196007159	active site
1192196007160	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1192196007161	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1192196007162	putative phosphate acyltransferase; Provisional; Region: PRK05331
1192196007163	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
1192196007164	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
1192196007165	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1192196007166	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1192196007167	generic binding surface II; other site
1192196007168	ssDNA binding site; other site
1192196007169	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1192196007170	ATP binding site [chemical binding]; other site
1192196007171	putative Mg++ binding site [ion binding]; other site
1192196007172	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1192196007173	nucleotide binding region [chemical binding]; other site
1192196007174	ATP-binding site [chemical binding]; other site
1192196007175	L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Region: sda_alpha; TIGR00718
1192196007176	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1192196007177	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1192196007178	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1192196007179	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
1192196007180	putative L-serine binding site [chemical binding]; other site
1192196007181	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1192196007182	DAK2 domain; Region: Dak2; pfam02734
1192196007183	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1192196007184	stage V sporulation protein M; Provisional; Region: spoVM; PRK14741
1192196007185	Thiamine pyrophosphokinase; Region: TPK; cd07995
1192196007186	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
1192196007187	active site
1192196007188	dimerization interface [polypeptide binding]; other site
1192196007189	thiamine binding site [chemical binding]; other site
1192196007190	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1192196007191	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1192196007192	substrate binding site [chemical binding]; other site
1192196007193	hexamer interface [polypeptide binding]; other site
1192196007194	metal binding site [ion binding]; metal-binding site
1192196007195	GTPase RsgA; Reviewed; Region: PRK00098
1192196007196	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1192196007197	RNA binding site [nucleotide binding]; other site
1192196007198	homodimer interface [polypeptide binding]; other site
1192196007199	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1192196007200	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1192196007201	GTP/Mg2+ binding site [chemical binding]; other site
1192196007202	G4 box; other site
1192196007203	G5 box; other site
1192196007204	G1 box; other site
1192196007205	Switch I region; other site
1192196007206	G2 box; other site
1192196007207	G3 box; other site
1192196007208	Switch II region; other site
1192196007209	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1192196007210	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1192196007211	active site
1192196007212	ATP binding site [chemical binding]; other site
1192196007213	substrate binding site [chemical binding]; other site
1192196007214	activation loop (A-loop); other site
1192196007215	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1192196007216	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1192196007217	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1192196007218	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1192196007219	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1192196007220	Protein phosphatase 2C; Region: PP2C; pfam00481
1192196007221	active site
1192196007222	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1192196007223	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196007224	FeS/SAM binding site; other site
1192196007225	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1192196007226	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
1192196007227	putative RNA binding site [nucleotide binding]; other site
1192196007228	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196007229	S-adenosylmethionine binding site [chemical binding]; other site
1192196007230	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1192196007231	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1192196007232	putative active site [active]
1192196007233	substrate binding site [chemical binding]; other site
1192196007234	putative cosubstrate binding site; other site
1192196007235	catalytic site [active]
1192196007236	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1192196007237	substrate binding site [chemical binding]; other site
1192196007238	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1192196007239	active site
1192196007240	catalytic residues [active]
1192196007241	metal binding site [ion binding]; metal-binding site
1192196007242	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1192196007243	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1192196007244	ATP binding site [chemical binding]; other site
1192196007245	putative Mg++ binding site [ion binding]; other site
1192196007246	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1192196007247	nucleotide binding region [chemical binding]; other site
1192196007248	ATP-binding site [chemical binding]; other site
1192196007249	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1192196007250	Flavoprotein; Region: Flavoprotein; pfam02441
1192196007251	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1192196007252	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
1192196007253	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1192196007254	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1192196007255	catalytic site [active]
1192196007256	G-X2-G-X-G-K; other site
1192196007257	hypothetical protein; Provisional; Region: PRK04323
1192196007258	TIGR00255 family protein; Region: TIGR00255
1192196007259	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1192196007260	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1192196007261	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1192196007262	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1192196007263	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1192196007264	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1192196007265	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196007266	motif II; other site
1192196007267	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1192196007268	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1192196007269	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1192196007270	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
1192196007271	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1192196007272	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1192196007273	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1192196007274	putative active site [active]
1192196007275	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1192196007276	putative active site [active]
1192196007277	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1192196007278	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
1192196007279	active site
1192196007280	SAM binding site [chemical binding]; other site
1192196007281	homodimer interface [polypeptide binding]; other site
1192196007282	AAA domain; Region: AAA_33; pfam13671
1192196007283	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1192196007284	ligand-binding site [chemical binding]; other site
1192196007285	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
1192196007286	ATP-sulfurylase; Region: ATPS; cd00517
1192196007287	active site
1192196007288	HXXH motif; other site
1192196007289	flexible loop; other site
1192196007290	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1192196007291	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1192196007292	active site
1192196007293	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1192196007294	active site
1192196007295	dimer interface [polypeptide binding]; other site
1192196007296	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1192196007297	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1192196007298	heterodimer interface [polypeptide binding]; other site
1192196007299	active site
1192196007300	FMN binding site [chemical binding]; other site
1192196007301	homodimer interface [polypeptide binding]; other site
1192196007302	substrate binding site [chemical binding]; other site
1192196007303	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
1192196007304	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
1192196007305	FAD binding pocket [chemical binding]; other site
1192196007306	FAD binding motif [chemical binding]; other site
1192196007307	phosphate binding motif [ion binding]; other site
1192196007308	beta-alpha-beta structure motif; other site
1192196007309	NAD binding pocket [chemical binding]; other site
1192196007310	Iron coordination center [ion binding]; other site
1192196007311	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1192196007312	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1192196007313	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1192196007314	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1192196007315	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1192196007316	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1192196007317	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1192196007318	IMP binding site; other site
1192196007319	dimer interface [polypeptide binding]; other site
1192196007320	interdomain contacts; other site
1192196007321	partial ornithine binding site; other site
1192196007322	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1192196007323	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1192196007324	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1192196007325	catalytic site [active]
1192196007326	subunit interface [polypeptide binding]; other site
1192196007327	dihydroorotase; Validated; Region: pyrC; PRK09357
1192196007328	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1192196007329	active site
1192196007330	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1192196007331	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1192196007332	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1192196007333	uracil-xanthine permease; Region: ncs2; TIGR00801
1192196007334	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1192196007335	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1192196007336	active site
1192196007337	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1192196007338	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1192196007339	RNA binding surface [nucleotide binding]; other site
1192196007340	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1192196007341	active site
1192196007342	lipoprotein signal peptidase; Provisional; Region: PRK14787
1192196007343	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1192196007344	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
1192196007345	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1192196007346	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1192196007347	HIGH motif; other site
1192196007348	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1192196007349	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1192196007350	active site
1192196007351	KMSKS motif; other site
1192196007352	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1192196007353	tRNA binding surface [nucleotide binding]; other site
1192196007354	anticodon binding site; other site
1192196007355	DivIVA protein; Region: DivIVA; pfam05103
1192196007356	DivIVA domain; Region: DivI1A_domain; TIGR03544
1192196007357	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1192196007358	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1192196007359	RNA binding surface [nucleotide binding]; other site
1192196007360	YGGT family; Region: YGGT; pfam02325
1192196007361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1192196007362	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1192196007363	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1192196007364	catalytic residue [active]
1192196007365	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1192196007366	uncharacterized protein, YfiH family; Region: TIGR00726
1192196007367	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
1192196007368	acetylornithine deacetylase; Validated; Region: PRK08596
1192196007369	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1192196007370	metal binding site [ion binding]; metal-binding site
1192196007371	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1192196007372	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1192196007373	Walker A/P-loop; other site
1192196007374	ATP binding site [chemical binding]; other site
1192196007375	Q-loop/lid; other site
1192196007376	ABC transporter signature motif; other site
1192196007377	Walker B; other site
1192196007378	D-loop; other site
1192196007379	H-loop/switch region; other site
1192196007380	sporulation sigma factor SigG; Reviewed; Region: PRK08215
1192196007381	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196007382	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1192196007383	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196007384	DNA binding residues [nucleotide binding]
1192196007385	sporulation sigma factor SigE; Reviewed; Region: PRK08301
1192196007386	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196007387	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196007388	DNA binding residues [nucleotide binding]
1192196007389	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
1192196007390	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
1192196007391	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1192196007392	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1192196007393	Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481
1192196007394	active site
1192196007395	catalytic triad [active]
1192196007396	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
1192196007397	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
1192196007398	Cna protein B-type domain; Region: Cna_B_2; pfam13715
1192196007399	Cna protein B-type domain; Region: Cna_B_2; pfam13715
1192196007400	cell division protein FtsZ; Validated; Region: PRK09330
1192196007401	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1192196007402	nucleotide binding site [chemical binding]; other site
1192196007403	SulA interaction site; other site
1192196007404	cell division protein FtsA; Region: ftsA; TIGR01174
1192196007405	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1192196007406	nucleotide binding site [chemical binding]; other site
1192196007407	Cell division protein FtsA; Region: FtsA; pfam14450
1192196007408	Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856
1192196007409	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1192196007410	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1192196007411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1192196007412	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1192196007413	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1192196007414	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1192196007415	Cell division protein FtsQ; Region: FtsQ; pfam03799
1192196007416	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1192196007417	FAD binding domain; Region: FAD_binding_4; pfam01565
1192196007418	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1192196007419	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1192196007420	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1192196007421	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1192196007422	homodimer interface [polypeptide binding]; other site
1192196007423	stage V sporulation protein E; Region: spoVE; TIGR02615
1192196007424	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1192196007425	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1192196007426	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1192196007427	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
1192196007428	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1192196007429	Mg++ binding site [ion binding]; other site
1192196007430	putative catalytic motif [active]
1192196007431	putative substrate binding site [chemical binding]; other site
1192196007432	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1192196007433	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1192196007434	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1192196007435	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1192196007436	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
1192196007437	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1192196007438	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1192196007439	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
1192196007440	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1192196007441	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1192196007442	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1192196007443	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1192196007444	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1192196007445	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
1192196007446	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1192196007447	MraW methylase family; Region: Methyltransf_5; pfam01795
1192196007448	mraZ protein; Region: TIGR00242
1192196007449	MraZ protein; Region: MraZ; pfam02381
1192196007450	MraZ protein; Region: MraZ; pfam02381
1192196007451	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
1192196007452	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
1192196007453	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
1192196007454	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1192196007455	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1192196007456	hypothetical protein; Provisional; Region: PRK13688
1192196007457	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196007458	Coenzyme A binding pocket [chemical binding]; other site
1192196007459	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1192196007460	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
1192196007461	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1192196007462	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1192196007463	hypothetical protein; Provisional; Region: PRK13670
1192196007464	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
1192196007465	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1192196007466	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
1192196007467	protein binding site [polypeptide binding]; other site
1192196007468	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1192196007469	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1192196007470	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
1192196007471	nucleophile elbow; other site
1192196007472	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1192196007473	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
1192196007474	Nucleoside recognition; Region: Gate; pfam07670
1192196007475	Nucleoside recognition; Region: Gate; pfam07670
1192196007476	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1192196007477	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1192196007478	active site
1192196007479	(T/H)XGH motif; other site
1192196007480	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1192196007481	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196007482	S-adenosylmethionine binding site [chemical binding]; other site
1192196007483	hypothetical protein; Provisional; Region: PRK02886
1192196007484	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
1192196007485	YlbE-like protein; Region: YlbE; pfam14003
1192196007486	Putative coat protein; Region: YlbD_coat; pfam14071
1192196007487	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1192196007488	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1192196007489	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1192196007490	FOG: CBS domain [General function prediction only]; Region: COG0517
1192196007491	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1192196007492	YugN-like family; Region: YugN; pfam08868
1192196007493	cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737
1192196007494	cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908
1192196007495	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1192196007496	Subunit I/III interface [polypeptide binding]; other site
1192196007497	Subunit III/IV interface [polypeptide binding]; other site
1192196007498	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1192196007499	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1192196007500	Putative ubiquinol binding site [chemical binding]; other site
1192196007501	Low-spin heme (heme b) binding site [chemical binding]; other site
1192196007502	D-pathway; other site
1192196007503	Putative water exit pathway; other site
1192196007504	Binuclear center (heme o3/CuB) [ion binding]; other site
1192196007505	K-pathway; other site
1192196007506	Putative proton exit pathway; other site
1192196007507	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1192196007508	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1192196007509	Cytochrome c; Region: Cytochrom_C; pfam00034
1192196007510	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1192196007511	UbiA prenyltransferase family; Region: UbiA; pfam01040
1192196007512	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1192196007513	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1192196007514	pyruvate carboxylase; Reviewed; Region: PRK12999
1192196007515	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1192196007516	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1192196007517	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1192196007518	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1192196007519	active site
1192196007520	catalytic residues [active]
1192196007521	metal binding site [ion binding]; metal-binding site
1192196007522	homodimer binding site [polypeptide binding]; other site
1192196007523	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1192196007524	carboxyltransferase (CT) interaction site; other site
1192196007525	biotinylation site [posttranslational modification]; other site
1192196007526	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
1192196007527	hypothetical protein; Provisional; Region: PRK13666
1192196007528	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1192196007529	glutaminase A; Region: Gln_ase; TIGR03814
1192196007530	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1192196007531	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1192196007532	putative active site [active]
1192196007533	PhoH-like protein; Region: PhoH; pfam02562
1192196007534	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
1192196007535	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1192196007536	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896
1192196007537	YlaH-like protein; Region: YlaH; pfam14036
1192196007538	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1192196007539	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1192196007540	G1 box; other site
1192196007541	putative GEF interaction site [polypeptide binding]; other site
1192196007542	GTP/Mg2+ binding site [chemical binding]; other site
1192196007543	Switch I region; other site
1192196007544	G2 box; other site
1192196007545	G3 box; other site
1192196007546	Switch II region; other site
1192196007547	G4 box; other site
1192196007548	G5 box; other site
1192196007549	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1192196007550	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1192196007551	Putative zinc-finger; Region: zf-HC2; pfam13490
1192196007552	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196007553	RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950
1192196007554	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196007555	DNA binding residues [nucleotide binding]
1192196007556	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1192196007557	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1192196007558	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1192196007559	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1192196007560	active site
1192196007561	Zn binding site [ion binding]; other site
1192196007562	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1192196007563	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1192196007564	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1192196007565	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1192196007566	active site
1192196007567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1192196007568	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1192196007569	Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256
1192196007570	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1192196007571	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1192196007572	homodimer interface [polypeptide binding]; other site
1192196007573	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196007574	catalytic residue [active]
1192196007575	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1192196007576	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1192196007577	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1192196007578	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1192196007579	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1192196007580	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1192196007581	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1192196007582	E3 interaction surface; other site
1192196007583	lipoyl attachment site [posttranslational modification]; other site
1192196007584	e3 binding domain; Region: E3_binding; pfam02817
1192196007585	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1192196007586	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1192196007587	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1192196007588	alpha subunit interface [polypeptide binding]; other site
1192196007589	TPP binding site [chemical binding]; other site
1192196007590	heterodimer interface [polypeptide binding]; other site
1192196007591	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1192196007592	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1192196007593	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1192196007594	TPP-binding site [chemical binding]; other site
1192196007595	tetramer interface [polypeptide binding]; other site
1192196007596	heterodimer interface [polypeptide binding]; other site
1192196007597	phosphorylation loop region [posttranslational modification]
1192196007598	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
1192196007599	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1192196007600	active site
1192196007601	catalytic residues [active]
1192196007602	metal binding site [ion binding]; metal-binding site
1192196007603	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1192196007604	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196007605	active site
1192196007606	motif I; other site
1192196007607	motif II; other site
1192196007608	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196007609	hypothetical protein; Provisional; Region: PRK13667
1192196007610	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1192196007611	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1192196007612	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1192196007613	adenine deaminase; Region: ade; TIGR01178
1192196007614	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1192196007615	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1192196007616	active site
1192196007617	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1192196007618	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1192196007619	TrkA-N domain; Region: TrkA_N; pfam02254
1192196007620	TrkA-C domain; Region: TrkA_C; pfam02080
1192196007621	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1192196007622	putative active site pocket [active]
1192196007623	dimerization interface [polypeptide binding]; other site
1192196007624	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1192196007625	putative active site pocket [active]
1192196007626	dimerization interface [polypeptide binding]; other site
1192196007627	putative catalytic residue [active]
1192196007628	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1192196007629	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196007630	putative active site [active]
1192196007631	heme pocket [chemical binding]; other site
1192196007632	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196007633	dimer interface [polypeptide binding]; other site
1192196007634	phosphorylation site [posttranslational modification]
1192196007635	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196007636	ATP binding site [chemical binding]; other site
1192196007637	Mg2+ binding site [ion binding]; other site
1192196007638	G-X-G motif; other site
1192196007639	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1192196007640	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1192196007641	rod-share determining protein MreBH; Provisional; Region: PRK13929
1192196007642	MreB and similar proteins; Region: MreB_like; cd10225
1192196007643	nucleotide binding site [chemical binding]; other site
1192196007644	Mg binding site [ion binding]; other site
1192196007645	putative protofilament interaction site [polypeptide binding]; other site
1192196007646	RodZ interaction site [polypeptide binding]; other site
1192196007647	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1192196007648	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1192196007649	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1192196007650	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1192196007651	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1192196007652	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1192196007653	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1192196007654	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1192196007655	ABC transporter; Region: ABC_tran_2; pfam12848
1192196007656	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1192196007657	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1192196007658	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1192196007659	Catalytic site [active]
1192196007660	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1192196007661	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1192196007662	active site
1192196007663	phosphorylation site [posttranslational modification]
1192196007664	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1192196007665	active site
1192196007666	P-loop; other site
1192196007667	phosphorylation site [posttranslational modification]
1192196007668	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1192196007669	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1192196007670	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1192196007671	putative substrate binding site [chemical binding]; other site
1192196007672	putative ATP binding site [chemical binding]; other site
1192196007673	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1192196007674	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1192196007675	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1192196007676	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1192196007677	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1192196007678	FtsX-like permease family; Region: FtsX; pfam02687
1192196007679	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1192196007680	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1192196007681	Walker A/P-loop; other site
1192196007682	ATP binding site [chemical binding]; other site
1192196007683	Q-loop/lid; other site
1192196007684	ABC transporter signature motif; other site
1192196007685	Walker B; other site
1192196007686	D-loop; other site
1192196007687	H-loop/switch region; other site
1192196007688	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
1192196007689	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1192196007690	HlyD family secretion protein; Region: HlyD_3; pfam13437
1192196007691	Yip1 domain; Region: Yip1; pfam04893
1192196007692	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1192196007693	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1192196007694	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1192196007695	Walker A/P-loop; other site
1192196007696	ATP binding site [chemical binding]; other site
1192196007697	Q-loop/lid; other site
1192196007698	ABC transporter signature motif; other site
1192196007699	Walker B; other site
1192196007700	D-loop; other site
1192196007701	H-loop/switch region; other site
1192196007702	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1192196007703	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1192196007704	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1192196007705	Walker A/P-loop; other site
1192196007706	ATP binding site [chemical binding]; other site
1192196007707	Q-loop/lid; other site
1192196007708	ABC transporter signature motif; other site
1192196007709	Walker B; other site
1192196007710	D-loop; other site
1192196007711	H-loop/switch region; other site
1192196007712	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1192196007713	MoaE interaction surface [polypeptide binding]; other site
1192196007714	MoeB interaction surface [polypeptide binding]; other site
1192196007715	thiocarboxylated glycine; other site
1192196007716	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1192196007717	MoaE homodimer interface [polypeptide binding]; other site
1192196007718	MoaD interaction [polypeptide binding]; other site
1192196007719	active site residues [active]
1192196007720	Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
1192196007721	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1192196007722	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1192196007723	dimer interface [polypeptide binding]; other site
1192196007724	putative functional site; other site
1192196007725	putative MPT binding site; other site
1192196007726	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
1192196007727	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1192196007728	ATP binding site [chemical binding]; other site
1192196007729	substrate interface [chemical binding]; other site
1192196007730	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1192196007731	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1192196007732	GTP binding site; other site
1192196007733	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1192196007734	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1192196007735	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1192196007736	catalytic residues [active]
1192196007737	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1192196007738	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1192196007739	dimer interface [polypeptide binding]; other site
1192196007740	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1192196007741	catalytic triad [active]
1192196007742	peroxidatic and resolving cysteines [active]
1192196007743	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1192196007744	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1192196007745	hypothetical protein; Provisional; Region: PRK03094
1192196007746	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1192196007747	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
1192196007748	metal binding site [ion binding]; metal-binding site
1192196007749	putative dimer interface [polypeptide binding]; other site
1192196007750	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1192196007751	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1192196007752	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1192196007753	active site
1192196007754	trimer interface [polypeptide binding]; other site
1192196007755	substrate binding site [chemical binding]; other site
1192196007756	CoA binding site [chemical binding]; other site
1192196007757	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1192196007758	flavodoxin, short chain; Region: flav_short; TIGR01753
1192196007759	BNR repeat-like domain; Region: BNR_2; pfam13088
1192196007760	flavodoxin; Provisional; Region: PRK06703
1192196007761	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196007762	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196007763	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1192196007764	dimerization interface [polypeptide binding]; other site
1192196007765	FOG: CBS domain [General function prediction only]; Region: COG0517
1192196007766	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1192196007767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
1192196007768	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1192196007769	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
1192196007770	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1192196007771	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1192196007772	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1192196007773	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
1192196007774	active site
1192196007775	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
1192196007776	NAD(P) binding site [chemical binding]; other site
1192196007777	substrate binding site [chemical binding]; other site
1192196007778	homotetramer interface [polypeptide binding]; other site
1192196007779	active site
1192196007780	homodimer interface [polypeptide binding]; other site
1192196007781	phosphodiesterase YaeI; Provisional; Region: PRK11340
1192196007782	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1192196007783	putative active site [active]
1192196007784	putative metal binding site [ion binding]; other site
1192196007785	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196007786	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1192196007787	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1192196007788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196007789	H+ Antiporter protein; Region: 2A0121; TIGR00900
1192196007790	putative substrate translocation pore; other site
1192196007791	YkyB-like protein; Region: YkyB; pfam14177
1192196007792	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1192196007793	putative CheA interaction surface; other site
1192196007794	Response regulator receiver domain; Region: Response_reg; pfam00072
1192196007795	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196007796	active site
1192196007797	phosphorylation site [posttranslational modification]
1192196007798	intermolecular recognition site; other site
1192196007799	dimerization interface [polypeptide binding]; other site
1192196007800	aminotransferase A; Validated; Region: PRK07683
1192196007801	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196007802	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196007803	homodimer interface [polypeptide binding]; other site
1192196007804	catalytic residue [active]
1192196007805	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196007806	putative active site [active]
1192196007807	heme pocket [chemical binding]; other site
1192196007808	PAS fold; Region: PAS; pfam00989
1192196007809	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196007810	putative active site [active]
1192196007811	heme pocket [chemical binding]; other site
1192196007812	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1192196007813	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196007814	putative active site [active]
1192196007815	heme pocket [chemical binding]; other site
1192196007816	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196007817	dimer interface [polypeptide binding]; other site
1192196007818	phosphorylation site [posttranslational modification]
1192196007819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196007820	ATP binding site [chemical binding]; other site
1192196007821	Mg2+ binding site [ion binding]; other site
1192196007822	G-X-G motif; other site
1192196007823	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1192196007824	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1192196007825	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1192196007826	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1192196007827	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1192196007828	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1192196007829	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1192196007830	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1192196007831	Cache domain; Region: Cache_1; pfam02743
1192196007832	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196007833	dimerization interface [polypeptide binding]; other site
1192196007834	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1192196007835	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1192196007836	dimer interface [polypeptide binding]; other site
1192196007837	putative CheW interface [polypeptide binding]; other site
1192196007838	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1192196007839	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196007840	Coenzyme A binding pocket [chemical binding]; other site
1192196007841	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1192196007842	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196007843	FeS/SAM binding site; other site
1192196007844	Transcriptional regulator protein (SplA); Region: SplA; pfam11132
1192196007845	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1192196007846	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1192196007847	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1192196007848	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1192196007849	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1192196007850	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1192196007851	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1192196007852	active site turn [active]
1192196007853	phosphorylation site [posttranslational modification]
1192196007854	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1192196007855	HPr interaction site; other site
1192196007856	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1192196007857	active site
1192196007858	phosphorylation site [posttranslational modification]
1192196007859	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1192196007860	CAT RNA binding domain; Region: CAT_RBD; pfam03123
1192196007861	PRD domain; Region: PRD; pfam00874
1192196007862	PRD domain; Region: PRD; pfam00874
1192196007863	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1192196007864	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1192196007865	DNA binding site [nucleotide binding]
1192196007866	domain linker motif; other site
1192196007867	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1192196007868	putative dimerization interface [polypeptide binding]; other site
1192196007869	putative ligand binding site [chemical binding]; other site
1192196007870	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1192196007871	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1192196007872	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1192196007873	active site
1192196007874	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1192196007875	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1192196007876	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196007877	motif II; other site
1192196007878	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1192196007879	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1192196007880	catalytic residues [active]
1192196007881	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1192196007882	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
1192196007883	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1192196007884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
1192196007885	Protein of unknown function (DUF3219); Region: DUF3219; pfam11514
1192196007886	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1192196007887	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1192196007888	active site
1192196007889	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
1192196007890	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1192196007891	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1192196007892	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196007893	short chain dehydrogenase; Provisional; Region: PRK06500
1192196007894	classical (c) SDRs; Region: SDR_c; cd05233
1192196007895	NAD(P) binding site [chemical binding]; other site
1192196007896	active site
1192196007897	Predicted transcriptional regulators [Transcription]; Region: COG1733
1192196007898	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1192196007899	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1192196007900	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
1192196007901	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196007902	FeS/SAM binding site; other site
1192196007903	6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039
1192196007904	active site
1192196007905	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1192196007906	Ligand Binding Site [chemical binding]; other site
1192196007907	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1192196007908	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1192196007909	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196007910	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1192196007911	Walker A motif; other site
1192196007912	ATP binding site [chemical binding]; other site
1192196007913	Walker B motif; other site
1192196007914	arginine finger; other site
1192196007915	UvrB/uvrC motif; Region: UVR; pfam02151
1192196007916	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196007917	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1192196007918	Walker A motif; other site
1192196007919	ATP binding site [chemical binding]; other site
1192196007920	Walker B motif; other site
1192196007921	arginine finger; other site
1192196007922	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1192196007923	flagellar motor protein MotA; Validated; Region: PRK08124
1192196007924	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1192196007925	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
1192196007926	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1192196007927	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1192196007928	ligand binding site [chemical binding]; other site
1192196007929	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196007930	MarR family; Region: MarR; pfam01047
1192196007931	Cache domain; Region: Cache_1; pfam02743
1192196007932	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1192196007933	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196007934	dimer interface [polypeptide binding]; other site
1192196007935	phosphorylation site [posttranslational modification]
1192196007936	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196007937	ATP binding site [chemical binding]; other site
1192196007938	Mg2+ binding site [ion binding]; other site
1192196007939	G-X-G motif; other site
1192196007940	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1192196007941	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1192196007942	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
1192196007943	Cupin domain; Region: Cupin_2; pfam07883
1192196007944	methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754
1192196007945	intersubunit interface [polypeptide binding]; other site
1192196007946	active site
1192196007947	Zn2+ binding site [ion binding]; other site
1192196007948	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196007949	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1192196007950	motif II; other site
1192196007951	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332
1192196007952	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
1192196007953	dimer interface [polypeptide binding]; other site
1192196007954	active site
1192196007955	catalytic residue [active]
1192196007956	metal binding site [ion binding]; metal-binding site
1192196007957	transaminase; Reviewed; Region: PRK08068
1192196007958	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196007959	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196007960	homodimer interface [polypeptide binding]; other site
1192196007961	catalytic residue [active]
1192196007962	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1192196007963	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1192196007964	putative active site [active]
1192196007965	catalytic triad [active]
1192196007966	putative dimer interface [polypeptide binding]; other site
1192196007967	Predicted kinase [General function prediction only]; Region: COG4857
1192196007968	Phosphotransferase enzyme family; Region: APH; pfam01636
1192196007969	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1192196007970	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
1192196007971	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1192196007972	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1192196007973	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1192196007974	DNA binding site [nucleotide binding]
1192196007975	active site
1192196007976	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196007977	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1192196007978	putative active site [active]
1192196007979	heme pocket [chemical binding]; other site
1192196007980	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196007981	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1192196007982	putative active site [active]
1192196007983	heme pocket [chemical binding]; other site
1192196007984	PAS domain; Region: PAS; smart00091
1192196007985	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1192196007986	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196007987	putative active site [active]
1192196007988	heme pocket [chemical binding]; other site
1192196007989	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196007990	dimer interface [polypeptide binding]; other site
1192196007991	phosphorylation site [posttranslational modification]
1192196007992	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196007993	ATP binding site [chemical binding]; other site
1192196007994	Mg2+ binding site [ion binding]; other site
1192196007995	G-X-G motif; other site
1192196007996	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1192196007997	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1192196007998	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1192196007999	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1192196008000	heat shock protein HtpX; Provisional; Region: PRK05457
1192196008001	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1192196008002	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1192196008003	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
1192196008004	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
1192196008005	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196008006	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1192196008007	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1192196008008	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1192196008009	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1192196008010	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1192196008011	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1192196008012	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1192196008013	PAS domain S-box; Region: sensory_box; TIGR00229
1192196008014	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1192196008015	metal binding site [ion binding]; metal-binding site
1192196008016	active site
1192196008017	I-site; other site
1192196008018	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1192196008019	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1192196008020	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1192196008021	putative DNA binding site [nucleotide binding]; other site
1192196008022	putative homodimer interface [polypeptide binding]; other site
1192196008023	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633
1192196008024	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1192196008025	active site
1192196008026	DNA binding site [nucleotide binding]
1192196008027	LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866
1192196008028	nucleotide binding site [chemical binding]; other site
1192196008029	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1192196008030	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1192196008031	Ligand binding site; other site
1192196008032	Putative Catalytic site; other site
1192196008033	DXD motif; other site
1192196008034	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
1192196008035	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1192196008036	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1192196008037	putative active site [active]
1192196008038	putative metal binding site [ion binding]; other site
1192196008039	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
1192196008040	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1192196008041	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196008042	MarR family; Region: MarR; pfam01047
1192196008043	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1192196008044	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1192196008045	DNA binding residues [nucleotide binding]
1192196008046	putative dimer interface [polypeptide binding]; other site
1192196008047	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
1192196008048	MgtE intracellular N domain; Region: MgtE_N; smart00924
1192196008049	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1192196008050	Divalent cation transporter; Region: MgtE; pfam01769
1192196008051	Transcriptional regulator protein (SplA); Region: SplA; pfam11132
1192196008052	Predicted membrane protein [Function unknown]; Region: COG3212
1192196008053	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1192196008054	Predicted membrane protein [Function unknown]; Region: COG3212
1192196008055	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1192196008056	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1192196008057	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196008058	dimerization interface [polypeptide binding]; other site
1192196008059	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196008060	dimer interface [polypeptide binding]; other site
1192196008061	phosphorylation site [posttranslational modification]
1192196008062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196008063	ATP binding site [chemical binding]; other site
1192196008064	Mg2+ binding site [ion binding]; other site
1192196008065	G-X-G motif; other site
1192196008066	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1192196008067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196008068	active site
1192196008069	phosphorylation site [posttranslational modification]
1192196008070	intermolecular recognition site; other site
1192196008071	dimerization interface [polypeptide binding]; other site
1192196008072	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1192196008073	DNA binding site [nucleotide binding]
1192196008074	YKOF-related Family; Region: Ykof; pfam07615
1192196008075	YKOF-related Family; Region: Ykof; pfam07615
1192196008076	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
1192196008077	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1192196008078	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1192196008079	Walker A/P-loop; other site
1192196008080	ATP binding site [chemical binding]; other site
1192196008081	Q-loop/lid; other site
1192196008082	ABC transporter signature motif; other site
1192196008083	Walker B; other site
1192196008084	D-loop; other site
1192196008085	H-loop/switch region; other site
1192196008086	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1192196008087	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1192196008088	Walker A/P-loop; other site
1192196008089	ATP binding site [chemical binding]; other site
1192196008090	Q-loop/lid; other site
1192196008091	ABC transporter signature motif; other site
1192196008092	Walker B; other site
1192196008093	D-loop; other site
1192196008094	H-loop/switch region; other site
1192196008095	Cobalt transport protein; Region: CbiQ; pfam02361
1192196008096	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1192196008097	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1192196008098	active site
1192196008099	catalytic residues [active]
1192196008100	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1192196008101	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371
1192196008102	THF binding site; other site
1192196008103	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1192196008104	substrate binding site [chemical binding]; other site
1192196008105	THF binding site; other site
1192196008106	zinc-binding site [ion binding]; other site
1192196008107	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1192196008108	nucleoside/Zn binding site; other site
1192196008109	dimer interface [polypeptide binding]; other site
1192196008110	catalytic motif [active]
1192196008111	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1192196008112	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1192196008113	MarR family; Region: MarR; pfam01047
1192196008114	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1192196008115	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1192196008116	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1192196008117	putative catalytic cysteine [active]
1192196008118	glutamate 5-kinase; Region: proB; TIGR01027
1192196008119	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1192196008120	nucleotide binding site [chemical binding]; other site
1192196008121	homotetrameric interface [polypeptide binding]; other site
1192196008122	putative phosphate binding site [ion binding]; other site
1192196008123	putative allosteric binding site; other site
1192196008124	PUA domain; Region: PUA; pfam01472
1192196008125	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1192196008126	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1192196008127	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1192196008128	putative active site [active]
1192196008129	putative substrate binding site [chemical binding]; other site
1192196008130	putative cosubstrate binding site; other site
1192196008131	catalytic site [active]
1192196008132	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1192196008133	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
1192196008134	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1192196008135	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1192196008136	DinB superfamily; Region: DinB_2; pfam12867
1192196008137	Predicted membrane protein [Function unknown]; Region: COG2323
1192196008138	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1192196008139	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1192196008140	heme-binding site [chemical binding]; other site
1192196008141	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1192196008142	FAD binding pocket [chemical binding]; other site
1192196008143	FAD binding motif [chemical binding]; other site
1192196008144	phosphate binding motif [ion binding]; other site
1192196008145	beta-alpha-beta structure motif; other site
1192196008146	NAD binding pocket [chemical binding]; other site
1192196008147	Heme binding  pocket [chemical binding]; other site
1192196008148	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1192196008149	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1192196008150	Amidinotransferase; Region: Amidinotransf; cl12043
1192196008151	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
1192196008152	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1192196008153	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1192196008154	Walker A/P-loop; other site
1192196008155	ATP binding site [chemical binding]; other site
1192196008156	Q-loop/lid; other site
1192196008157	ABC transporter signature motif; other site
1192196008158	Walker B; other site
1192196008159	D-loop; other site
1192196008160	H-loop/switch region; other site
1192196008161	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1192196008162	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1192196008163	NlpC/P60 family; Region: NLPC_P60; pfam00877
1192196008164	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1192196008165	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1192196008166	active site
1192196008167	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1192196008168	dimer interface [polypeptide binding]; other site
1192196008169	catalytic triad [active]
1192196008170	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1192196008171	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1192196008172	peptide binding site [polypeptide binding]; other site
1192196008173	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1192196008174	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1192196008175	Walker A/P-loop; other site
1192196008176	ATP binding site [chemical binding]; other site
1192196008177	Q-loop/lid; other site
1192196008178	ABC transporter signature motif; other site
1192196008179	Walker B; other site
1192196008180	D-loop; other site
1192196008181	H-loop/switch region; other site
1192196008182	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1192196008183	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1192196008184	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1192196008185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196008186	dimer interface [polypeptide binding]; other site
1192196008187	conserved gate region; other site
1192196008188	putative PBP binding loops; other site
1192196008189	ABC-ATPase subunit interface; other site
1192196008190	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1192196008191	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196008192	dimer interface [polypeptide binding]; other site
1192196008193	conserved gate region; other site
1192196008194	putative PBP binding loops; other site
1192196008195	ABC-ATPase subunit interface; other site
1192196008196	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281
1192196008197	SxDxEG motif; other site
1192196008198	active site
1192196008199	metal binding site [ion binding]; metal-binding site
1192196008200	homopentamer interface [polypeptide binding]; other site
1192196008201	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928
1192196008202	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
1192196008203	Trypsin; Region: Trypsin; pfam00089
1192196008204	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1192196008205	protein binding site [polypeptide binding]; other site
1192196008206	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1192196008207	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1192196008208	Ligand binding site; other site
1192196008209	Putative Catalytic site; other site
1192196008210	DXD motif; other site
1192196008211	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1192196008212	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1192196008213	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1192196008214	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1192196008215	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196008216	Zn binding site [ion binding]; other site
1192196008217	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1192196008218	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196008219	Zn binding site [ion binding]; other site
1192196008220	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
1192196008221	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1192196008222	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1192196008223	Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171
1192196008224	Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185
1192196008225	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1192196008226	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1192196008227	amidase catalytic site [active]
1192196008228	Zn binding residues [ion binding]; other site
1192196008229	substrate binding site [chemical binding]; other site
1192196008230	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1192196008231	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196008232	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1192196008233	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1192196008234	Phage lysis protein, holin; Region: Phage_holin; cl04675
1192196008235	Haemolysin XhlA; Region: XhlA; pfam10779
1192196008236	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
1192196008237	XkdW protein; Region: XkdW; pfam09636
1192196008238	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
1192196008239	Hexamer interface [polypeptide binding]; other site
1192196008240	Hexagonal pore residue; other site
1192196008241	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
1192196008242	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
1192196008243	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
1192196008244	Protein of unknown function (DUF2577); Region: DUF2577; pfam10844
1192196008245	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
1192196008246	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
1192196008247	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196008248	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1192196008249	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1192196008250	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1192196008251	catalytic residue [active]
1192196008252	Phage XkdN-like protein; Region: XkdN; pfam08890
1192196008253	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
1192196008254	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
1192196008255	Domain of unknown function (DUF3599); Region: DUF3599; pfam12206
1192196008256	Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053
1192196008257	Phage capsid family; Region: Phage_capsid; pfam05065
1192196008258	Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518
1192196008259	Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783
1192196008260	Terminase-like family; Region: Terminase_6; pfam03237
1192196008261	Phage terminase small subunit; Region: Phage_terminase; pfam10668
1192196008262	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
1192196008263	positive control sigma-like factor; Validated; Region: PRK06930
1192196008264	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196008265	DNA binding residues [nucleotide binding]
1192196008266	hypothetical protein; Provisional; Region: PRK06921
1192196008267	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196008268	Walker A motif; other site
1192196008269	ATP binding site [chemical binding]; other site
1192196008270	Walker B motif; other site
1192196008271	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1192196008272	putative Zn2+ binding site [ion binding]; other site
1192196008273	putative DNA binding site [nucleotide binding]; other site
1192196008274	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1192196008275	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1192196008276	non-specific DNA binding site [nucleotide binding]; other site
1192196008277	salt bridge; other site
1192196008278	sequence-specific DNA binding site [nucleotide binding]; other site
1192196008279	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1192196008280	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1192196008281	dimanganese center [ion binding]; other site
1192196008282	Phage-related replication protein [General function prediction only]; Region: COG4195
1192196008283	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1192196008284	pentamer interface [polypeptide binding]; other site
1192196008285	dodecaamer interface [polypeptide binding]; other site
1192196008286	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1192196008287	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1192196008288	amidase catalytic site [active]
1192196008289	Zn binding residues [ion binding]; other site
1192196008290	substrate binding site [chemical binding]; other site
1192196008291	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1192196008292	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196008293	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1192196008294	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1192196008295	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
1192196008296	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196008297	binding surface
1192196008298	TPR motif; other site
1192196008299	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1192196008300	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196008301	binding surface
1192196008302	TPR motif; other site
1192196008303	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196008304	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1192196008305	Walker A motif; other site
1192196008306	ATP binding site [chemical binding]; other site
1192196008307	Walker B motif; other site
1192196008308	arginine finger; other site
1192196008309	DinB family; Region: DinB; pfam05163
1192196008310	DinB superfamily; Region: DinB_2; pfam12867
1192196008311	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1192196008312	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1192196008313	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1192196008314	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1192196008315	altronate oxidoreductase; Provisional; Region: PRK03643
1192196008316	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1192196008317	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1192196008318	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1192196008319	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1192196008320	DNA binding site [nucleotide binding]
1192196008321	domain linker motif; other site
1192196008322	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1192196008323	dimerization interface [polypeptide binding]; other site
1192196008324	ligand binding site [chemical binding]; other site
1192196008325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196008326	D-galactonate transporter; Region: 2A0114; TIGR00893
1192196008327	putative substrate translocation pore; other site
1192196008328	D-mannonate oxidoreductase; Provisional; Region: PRK08277
1192196008329	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
1192196008330	putative NAD(P) binding site [chemical binding]; other site
1192196008331	active site
1192196008332	mannonate dehydratase; Provisional; Region: PRK03906
1192196008333	mannonate dehydratase; Region: uxuA; TIGR00695
1192196008334	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1192196008335	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1192196008336	putative NAD(P) binding site [chemical binding]; other site
1192196008337	catalytic Zn binding site [ion binding]; other site
1192196008338	structural Zn binding site [ion binding]; other site
1192196008339	Malate/L-lactate dehydrogenase; Region: Ldh_2; pfam02615
1192196008340	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1192196008341	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196008342	putative substrate translocation pore; other site
1192196008343	Glucuronate isomerase; Region: UxaC; pfam02614
1192196008344	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
1192196008345	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1192196008346	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1192196008347	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1192196008348	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
1192196008349	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1192196008350	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
1192196008351	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1192196008352	Walker A/P-loop; other site
1192196008353	ATP binding site [chemical binding]; other site
1192196008354	Q-loop/lid; other site
1192196008355	ABC transporter signature motif; other site
1192196008356	Walker B; other site
1192196008357	D-loop; other site
1192196008358	H-loop/switch region; other site
1192196008359	TIGR00245 family protein; Region: TIGR00245
1192196008360	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1192196008361	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1192196008362	active site
1192196008363	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1192196008364	glycosyltransferase, MGT family; Region: MGT; TIGR01426
1192196008365	active site
1192196008366	TDP-binding site; other site
1192196008367	acceptor substrate-binding pocket; other site
1192196008368	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1192196008369	Cytochrome P450; Region: p450; cl12078
1192196008370	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1192196008371	nudix motif; other site
1192196008372	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1192196008373	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1192196008374	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1192196008375	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1192196008376	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1192196008377	4Fe-4S binding domain; Region: Fer4; pfam00037
1192196008378	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1192196008379	[4Fe-4S] binding site [ion binding]; other site
1192196008380	molybdopterin cofactor binding site; other site
1192196008381	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1192196008382	molybdopterin cofactor binding site; other site
1192196008383	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
1192196008384	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
1192196008385	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
1192196008386	Putative motility protein; Region: YjfB_motility; pfam14070
1192196008387	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
1192196008388	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
1192196008389	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1192196008390	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1192196008391	Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947
1192196008392	NodB motif; other site
1192196008393	active site
1192196008394	catalytic site [active]
1192196008395	Zn binding site [ion binding]; other site
1192196008396	Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109
1192196008397	UbiA prenyltransferase family; Region: UbiA; pfam01040
1192196008398	Domain of unknown function (DUF4306); Region: DUF4306; pfam14154
1192196008399	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1192196008400	putative deacylase active site [active]
1192196008401	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1192196008402	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1192196008403	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
1192196008404	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1192196008405	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1192196008406	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1192196008407	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1192196008408	active site
1192196008409	P-loop; other site
1192196008410	phosphorylation site [posttranslational modification]
1192196008411	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1192196008412	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1192196008413	active site
1192196008414	phosphorylation site [posttranslational modification]
1192196008415	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1192196008416	HTH domain; Region: HTH_11; pfam08279
1192196008417	PRD domain; Region: PRD; pfam00874
1192196008418	PRD domain; Region: PRD; pfam00874
1192196008419	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1192196008420	active site
1192196008421	P-loop; other site
1192196008422	phosphorylation site [posttranslational modification]
1192196008423	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1192196008424	active site
1192196008425	phosphorylation site [posttranslational modification]
1192196008426	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1192196008427	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1192196008428	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748
1192196008429	classical (c) SDRs; Region: SDR_c; cd05233
1192196008430	NAD(P) binding site [chemical binding]; other site
1192196008431	active site
1192196008432	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1192196008433	Putative amidase domain; Region: Amidase_6; pfam12671
1192196008434	Predicted integral membrane protein [Function unknown]; Region: COG5505
1192196008435	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1192196008436	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1192196008437	cystathionine beta-lyase; Provisional; Region: PRK08064
1192196008438	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1192196008439	homodimer interface [polypeptide binding]; other site
1192196008440	substrate-cofactor binding pocket; other site
1192196008441	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196008442	catalytic residue [active]
1192196008443	cystathionine gamma-synthase; Reviewed; Region: PRK08247
1192196008444	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1192196008445	homodimer interface [polypeptide binding]; other site
1192196008446	substrate-cofactor binding pocket; other site
1192196008447	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196008448	catalytic residue [active]
1192196008449	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1192196008450	phosphodiesterase; Provisional; Region: PRK12704
1192196008451	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1192196008452	Putative esterase; Region: Esterase; pfam00756
1192196008453	hypothetical protein; Provisional; Region: PRK13679
1192196008454	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1192196008455	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196008456	Coenzyme A binding pocket [chemical binding]; other site
1192196008457	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1192196008458	Part of AAA domain; Region: AAA_19; pfam13245
1192196008459	Family description; Region: UvrD_C_2; pfam13538
1192196008460	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
1192196008461	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
1192196008462	Spore Coat Protein X and V domain; Region: Coat_X; pfam07552
1192196008463	Spore Coat Protein X and V domain; Region: Coat_X; pfam07552
1192196008464	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
1192196008465	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
1192196008466	Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153
1192196008467	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
1192196008468	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1192196008469	NAD binding site [chemical binding]; other site
1192196008470	homotetramer interface [polypeptide binding]; other site
1192196008471	homodimer interface [polypeptide binding]; other site
1192196008472	substrate binding site [chemical binding]; other site
1192196008473	active site
1192196008474	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1192196008475	dimer interface [polypeptide binding]; other site
1192196008476	substrate binding site [chemical binding]; other site
1192196008477	ATP binding site [chemical binding]; other site
1192196008478	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
1192196008479	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1192196008480	ATP binding site [chemical binding]; other site
1192196008481	substrate interface [chemical binding]; other site
1192196008482	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1192196008483	ThiS interaction site; other site
1192196008484	putative active site [active]
1192196008485	tetramer interface [polypeptide binding]; other site
1192196008486	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1192196008487	thiS-thiF/thiG interaction site; other site
1192196008488	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1192196008489	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1192196008490	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1192196008491	thiamine phosphate binding site [chemical binding]; other site
1192196008492	active site
1192196008493	pyrophosphate binding site [ion binding]; other site
1192196008494	thiaminase II; Region: salvage_TenA; TIGR04306
1192196008495	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1192196008496	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1192196008497	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1192196008498	TrkA-N domain; Region: TrkA_N; pfam02254
1192196008499	TrkA-C domain; Region: TrkA_C; pfam02080
1192196008500	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
1192196008501	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
1192196008502	active site
1192196008503	metal binding site [ion binding]; metal-binding site
1192196008504	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1192196008505	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1192196008506	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1192196008507	active site
1192196008508	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1192196008509	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1192196008510	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1192196008511	synthetase active site [active]
1192196008512	NTP binding site [chemical binding]; other site
1192196008513	metal binding site [ion binding]; metal-binding site
1192196008514	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1192196008515	putative active site [active]
1192196008516	putative metal binding residues [ion binding]; other site
1192196008517	signature motif; other site
1192196008518	putative triphosphate binding site [ion binding]; other site
1192196008519	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1192196008520	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1192196008521	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1192196008522	catalytic residue [active]
1192196008523	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1192196008524	apolar tunnel; other site
1192196008525	heme binding site [chemical binding]; other site
1192196008526	dimerization interface [polypeptide binding]; other site
1192196008527	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1192196008528	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
1192196008529	catalytic residues [active]
1192196008530	oligoendopeptidase F; Region: pepF; TIGR00181
1192196008531	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1192196008532	active site
1192196008533	Zn binding site [ion binding]; other site
1192196008534	Competence protein CoiA-like family, contains a predicted nuclease    domain [General function prediction only]; Region: CoiA; COG4469
1192196008535	adaptor protein; Provisional; Region: PRK02315
1192196008536	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1192196008537	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1192196008538	ArsC family; Region: ArsC; pfam03960
1192196008539	putative catalytic residues [active]
1192196008540	thiol/disulfide switch; other site
1192196008541	H+ Antiporter protein; Region: 2A0121; TIGR00900
1192196008542	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1192196008543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196008544	Walker A/P-loop; other site
1192196008545	ATP binding site [chemical binding]; other site
1192196008546	Q-loop/lid; other site
1192196008547	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1192196008548	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1192196008549	Walker A/P-loop; other site
1192196008550	ATP binding site [chemical binding]; other site
1192196008551	Q-loop/lid; other site
1192196008552	ABC transporter signature motif; other site
1192196008553	Walker B; other site
1192196008554	D-loop; other site
1192196008555	H-loop/switch region; other site
1192196008556	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1192196008557	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1192196008558	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1192196008559	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196008560	dimer interface [polypeptide binding]; other site
1192196008561	conserved gate region; other site
1192196008562	putative PBP binding loops; other site
1192196008563	ABC-ATPase subunit interface; other site
1192196008564	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1192196008565	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196008566	dimer interface [polypeptide binding]; other site
1192196008567	conserved gate region; other site
1192196008568	putative PBP binding loops; other site
1192196008569	ABC-ATPase subunit interface; other site
1192196008570	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1192196008571	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1192196008572	peptide binding site [polypeptide binding]; other site
1192196008573	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1192196008574	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1192196008575	active site
1192196008576	HIGH motif; other site
1192196008577	dimer interface [polypeptide binding]; other site
1192196008578	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1192196008579	KMSKS motif; other site
1192196008580	Protein of unknown function (DUF3603); Region: DUF3603; pfam12227
1192196008581	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1192196008582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196008583	dimer interface [polypeptide binding]; other site
1192196008584	conserved gate region; other site
1192196008585	putative PBP binding loops; other site
1192196008586	ABC-ATPase subunit interface; other site
1192196008587	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1192196008588	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196008589	dimer interface [polypeptide binding]; other site
1192196008590	conserved gate region; other site
1192196008591	putative PBP binding loops; other site
1192196008592	ABC-ATPase subunit interface; other site
1192196008593	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1192196008594	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
1192196008595	peptide binding site [polypeptide binding]; other site
1192196008596	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1192196008597	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1192196008598	Walker A/P-loop; other site
1192196008599	ATP binding site [chemical binding]; other site
1192196008600	Q-loop/lid; other site
1192196008601	ABC transporter signature motif; other site
1192196008602	Walker B; other site
1192196008603	D-loop; other site
1192196008604	H-loop/switch region; other site
1192196008605	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1192196008606	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1192196008607	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1192196008608	Walker A/P-loop; other site
1192196008609	ATP binding site [chemical binding]; other site
1192196008610	Q-loop/lid; other site
1192196008611	ABC transporter signature motif; other site
1192196008612	Walker B; other site
1192196008613	D-loop; other site
1192196008614	H-loop/switch region; other site
1192196008615	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1192196008616	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
1192196008617	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1192196008618	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1192196008619	dimer interface [polypeptide binding]; other site
1192196008620	active site
1192196008621	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1192196008622	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1192196008623	dimer interface [polypeptide binding]; other site
1192196008624	active site
1192196008625	CoA binding pocket [chemical binding]; other site
1192196008626	ComZ; Region: ComZ; pfam10815
1192196008627	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1192196008628	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
1192196008629	putative ligand binding site [chemical binding]; other site
1192196008630	UDP-apiose/xylose synthase; Region: PLN02427
1192196008631	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1192196008632	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
1192196008633	YjzC-like protein; Region: YjzC; pfam14168
1192196008634	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1192196008635	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1192196008636	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1192196008637	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815
1192196008638	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1192196008639	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1192196008640	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1192196008641	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1192196008642	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1192196008643	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838
1192196008644	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1192196008645	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1192196008646	subunit interface [polypeptide binding]; other site
1192196008647	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
1192196008648	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1192196008649	inhibitor-cofactor binding pocket; inhibition site
1192196008650	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196008651	catalytic residue [active]
1192196008652	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1192196008653	nucleotide binding site [chemical binding]; other site
1192196008654	N-acetyl-L-glutamate binding site [chemical binding]; other site
1192196008655	DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603
1192196008656	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1192196008657	active site pocket [active]
1192196008658	cleavage site
1192196008659	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
1192196008660	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1192196008661	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1192196008662	putative substrate translocation pore; other site
1192196008663	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1192196008664	FAD binding domain; Region: FAD_binding_4; pfam01565
1192196008665	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1192196008666	esterase; Provisional; Region: PRK10566
1192196008667	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1192196008668	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1192196008669	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196008670	motif II; other site
1192196008671	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196008672	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
1192196008673	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1192196008674	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1192196008675	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1192196008676	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1192196008677	EDD domain protein, DegV family; Region: DegV; TIGR00762
1192196008678	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1192196008679	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1192196008680	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1192196008681	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1192196008682	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1192196008683	active site
1192196008684	Zn binding site [ion binding]; other site
1192196008685	Predicted transcriptional regulators [Transcription]; Region: COG1695
1192196008686	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1192196008687	antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034
1192196008688	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
1192196008689	antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032
1192196008690	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1192196008691	S1 domain; Region: S1_2; pfam13509
1192196008692	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
1192196008693	RNA binding site [nucleotide binding]; other site
1192196008694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1192196008695	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1192196008696	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
1192196008697	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1192196008698	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1192196008699	FAD binding site [chemical binding]; other site
1192196008700	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196008701	Coenzyme A binding pocket [chemical binding]; other site
1192196008702	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1192196008703	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196008704	Coenzyme A binding pocket [chemical binding]; other site
1192196008705	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196008706	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196008707	putative substrate translocation pore; other site
1192196008708	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1192196008709	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1192196008710	active site pocket [active]
1192196008711	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1192196008712	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1192196008713	(2R)-phospho-3-sulfolactate synthase (PSL synthase, CoM    biosynthesis) [Coenzyme transport and metabolism]; Region: COG1809
1192196008714	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
1192196008715	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
1192196008716	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1192196008717	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1192196008718	Active Sites [active]
1192196008719	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
1192196008720	ATP-sulfurylase; Region: ATPS; cd00517
1192196008721	active site
1192196008722	HXXH motif; other site
1192196008723	flexible loop; other site
1192196008724	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1192196008725	ligand-binding site [chemical binding]; other site
1192196008726	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1192196008727	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1192196008728	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1192196008729	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1192196008730	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1192196008731	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1192196008732	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196008733	DNA-binding site [nucleotide binding]; DNA binding site
1192196008734	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196008735	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196008736	homodimer interface [polypeptide binding]; other site
1192196008737	catalytic residue [active]
1192196008738	Lysine efflux permease [General function prediction only]; Region: COG1279
1192196008739	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
1192196008740	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1192196008741	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1192196008742	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1192196008743	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1192196008744	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1192196008745	DNA binding site [nucleotide binding]
1192196008746	domain linker motif; other site
1192196008747	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1192196008748	dimerization interface [polypeptide binding]; other site
1192196008749	ligand binding site [chemical binding]; other site
1192196008750	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1192196008751	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1192196008752	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1192196008753	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1192196008754	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
1192196008755	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1192196008756	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
1192196008757	substrate binding pocket [chemical binding]; other site
1192196008758	aspartate-rich region 2; other site
1192196008759	substrate-Mg2+ binding site; other site
1192196008760	DinB family; Region: DinB; cl17821
1192196008761	DinB superfamily; Region: DinB_2; pfam12867
1192196008762	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
1192196008763	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1192196008764	dimer interface [polypeptide binding]; other site
1192196008765	active site
1192196008766	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1192196008767	Ligand Binding Site [chemical binding]; other site
1192196008768	Molecular Tunnel; other site
1192196008769	Protein of unknown function (DUF2777); Region: DUF2777; pfam10949
1192196008770	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1192196008771	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
1192196008772	active site
1192196008773	catalytic triad [active]
1192196008774	hypothetical protein; Provisional; Region: PRK13673
1192196008775	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1192196008776	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1192196008777	CotH protein; Region: CotH; pfam08757
1192196008778	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1192196008779	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1192196008780	Protein of unknown function (DUF2539); Region: DUF2539; pfam10803
1192196008781	Spore germination protein GerPC; Region: GerPC; pfam10737
1192196008782	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
1192196008783	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
1192196008784	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1192196008785	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1192196008786	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1192196008787	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1192196008788	Walker A/P-loop; other site
1192196008789	ATP binding site [chemical binding]; other site
1192196008790	Q-loop/lid; other site
1192196008791	ABC transporter signature motif; other site
1192196008792	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1192196008793	ABC transporter signature motif; other site
1192196008794	Walker B; other site
1192196008795	D-loop; other site
1192196008796	H-loop/switch region; other site
1192196008797	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1192196008798	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1192196008799	active site
1192196008800	metal binding site [ion binding]; metal-binding site
1192196008801	DNA binding site [nucleotide binding]
1192196008802	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1192196008803	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1192196008804	Part of AAA domain; Region: AAA_19; pfam13245
1192196008805	Family description; Region: UvrD_C_2; pfam13538
1192196008806	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1192196008807	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1192196008808	Uncharacterized conserved protein [Function unknown]; Region: COG1633
1192196008809	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1192196008810	dinuclear metal binding motif [ion binding]; other site
1192196008811	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
1192196008812	dimerization interface [polypeptide binding]; other site
1192196008813	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1192196008814	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1192196008815	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1192196008816	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196008817	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196008818	putative substrate translocation pore; other site
1192196008819	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1192196008820	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1192196008821	DNA binding site [nucleotide binding]
1192196008822	domain linker motif; other site
1192196008823	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1192196008824	putative dimerization interface [polypeptide binding]; other site
1192196008825	putative ligand binding site [chemical binding]; other site
1192196008826	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1192196008827	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1192196008828	inhibitor-cofactor binding pocket; inhibition site
1192196008829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196008830	catalytic residue [active]
1192196008831	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1192196008832	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196008833	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1192196008834	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1192196008835	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1192196008836	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1192196008837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196008838	putative substrate translocation pore; other site
1192196008839	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196008840	MarR family; Region: MarR; pfam01047
1192196008841	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1192196008842	hypothetical protein; Provisional; Region: PRK08244
1192196008843	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1192196008844	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1192196008845	Catalytic site [active]
1192196008846	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1192196008847	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1192196008848	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
1192196008849	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1192196008850	Na binding site [ion binding]; other site
1192196008851	oxidoreductase; Provisional; Region: PRK07985
1192196008852	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1192196008853	NAD binding site [chemical binding]; other site
1192196008854	metal binding site [ion binding]; metal-binding site
1192196008855	active site
1192196008856	Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
1192196008857	IDEAL domain; Region: IDEAL; pfam08858
1192196008858	short chain dehydrogenase; Provisional; Region: PRK06701
1192196008859	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1192196008860	NAD binding site [chemical binding]; other site
1192196008861	metal binding site [ion binding]; metal-binding site
1192196008862	active site
1192196008863	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1192196008864	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1192196008865	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1192196008866	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
1192196008867	[2Fe-2S] cluster binding site [ion binding]; other site
1192196008868	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
1192196008869	heme-binding site [chemical binding]; other site
1192196008870	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1192196008871	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1192196008872	dimer interface [polypeptide binding]; other site
1192196008873	putative CheW interface [polypeptide binding]; other site
1192196008874	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1192196008875	acyl-CoA synthetase; Validated; Region: PRK07638
1192196008876	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1192196008877	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
1192196008878	acyl-activating enzyme (AAE) consensus motif; other site
1192196008879	acyl-activating enzyme (AAE) consensus motif; other site
1192196008880	AMP binding site [chemical binding]; other site
1192196008881	active site
1192196008882	CoA binding site [chemical binding]; other site
1192196008883	acetyl-CoA acetyltransferase; Provisional; Region: PRK06690
1192196008884	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1192196008885	dimer interface [polypeptide binding]; other site
1192196008886	active site
1192196008887	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1192196008888	catalytic core [active]
1192196008889	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1192196008890	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1192196008891	siderophore binding site; other site
1192196008892	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
1192196008893	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1192196008894	putative NADP binding site [chemical binding]; other site
1192196008895	putative dimer interface [polypeptide binding]; other site
1192196008896	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1192196008897	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196008898	Coenzyme A binding pocket [chemical binding]; other site
1192196008899	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1192196008900	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1192196008901	active site
1192196008902	catalytic residues [active]
1192196008903	Peptidase family M48; Region: Peptidase_M48; pfam01435
1192196008904	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
1192196008905	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1192196008906	acyl-activating enzyme (AAE) consensus motif; other site
1192196008907	putative AMP binding site [chemical binding]; other site
1192196008908	putative active site [active]
1192196008909	putative CoA binding site [chemical binding]; other site
1192196008910	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1192196008911	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1192196008912	NAD(P) binding site [chemical binding]; other site
1192196008913	putative active site [active]
1192196008914	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1192196008915	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1192196008916	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1192196008917	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1192196008918	YhfH-like protein; Region: YhfH; pfam14149
1192196008919	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1192196008920	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1192196008921	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
1192196008922	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1192196008923	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1192196008924	putative oligomer interface [polypeptide binding]; other site
1192196008925	putative active site [active]
1192196008926	metal binding site [ion binding]; metal-binding site
1192196008927	Predicted membrane protein [Function unknown]; Region: COG4377
1192196008928	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
1192196008929	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1192196008930	dimer interface [polypeptide binding]; other site
1192196008931	active site
1192196008932	CoA binding pocket [chemical binding]; other site
1192196008933	Predicted membrane protein [Function unknown]; Region: COG1511
1192196008934	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1192196008935	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196008936	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196008937	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196008938	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1192196008939	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1192196008940	ferrochelatase; Provisional; Region: PRK12435
1192196008941	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1192196008942	C-terminal domain interface [polypeptide binding]; other site
1192196008943	active site
1192196008944	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1192196008945	active site
1192196008946	N-terminal domain interface [polypeptide binding]; other site
1192196008947	RNA island B
1192196008948	EcsC protein family; Region: EcsC; pfam12787
1192196008949	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
1192196008950	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1192196008951	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1192196008952	Walker A/P-loop; other site
1192196008953	ATP binding site [chemical binding]; other site
1192196008954	Q-loop/lid; other site
1192196008955	ABC transporter signature motif; other site
1192196008956	Walker B; other site
1192196008957	D-loop; other site
1192196008958	H-loop/switch region; other site
1192196008959	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1192196008960	HIT family signature motif; other site
1192196008961	catalytic residue [active]
1192196008962	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1192196008963	homodimer interface [polypeptide binding]; other site
1192196008964	substrate-cofactor binding pocket; other site
1192196008965	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196008966	catalytic residue [active]
1192196008967	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
1192196008968	transcriptional regulator Hpr; Provisional; Region: PRK13777
1192196008969	MarR family; Region: MarR; pfam01047
1192196008970	Protein of unknown function (DUF1878); Region: DUF1878; pfam08963
1192196008971	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1192196008972	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
1192196008973	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1192196008974	Sporulation protein YhaL; Region: Spore_YhaL; pfam14147
1192196008975	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1192196008976	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1192196008977	generic binding surface II; other site
1192196008978	generic binding surface I; other site
1192196008979	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1192196008980	Zn2+ binding site [ion binding]; other site
1192196008981	Mg2+ binding site [ion binding]; other site
1192196008982	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1192196008983	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1192196008984	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1192196008985	active site
1192196008986	metal binding site [ion binding]; metal-binding site
1192196008987	DNA binding site [nucleotide binding]
1192196008988	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1192196008989	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1192196008990	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1192196008991	ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269
1192196008992	Walker A/P-loop; other site
1192196008993	ATP binding site [chemical binding]; other site
1192196008994	Q-loop/lid; other site
1192196008995	ABC transporter signature motif; other site
1192196008996	Walker B; other site
1192196008997	D-loop; other site
1192196008998	H-loop/switch region; other site
1192196008999	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1192196009000	enoyl-CoA hydratase; Provisional; Region: PRK07659
1192196009001	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1192196009002	substrate binding site [chemical binding]; other site
1192196009003	oxyanion hole (OAH) forming residues; other site
1192196009004	trimer interface [polypeptide binding]; other site
1192196009005	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1192196009006	TrkA-C domain; Region: TrkA_C; pfam02080
1192196009007	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1192196009008	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1192196009009	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
1192196009010	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196009011	FeS/SAM binding site; other site
1192196009012	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1192196009013	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196009014	active site
1192196009015	motif I; other site
1192196009016	motif II; other site
1192196009017	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1192196009018	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
1192196009019	hypothetical protein; Provisional; Region: PRK13676
1192196009020	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
1192196009021	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1192196009022	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1192196009023	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1192196009024	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1192196009025	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1192196009026	NAD binding site [chemical binding]; other site
1192196009027	substrate binding site [chemical binding]; other site
1192196009028	putative active site [active]
1192196009029	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1192196009030	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1192196009031	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1192196009032	Walker A/P-loop; other site
1192196009033	ATP binding site [chemical binding]; other site
1192196009034	Q-loop/lid; other site
1192196009035	ABC transporter signature motif; other site
1192196009036	Walker B; other site
1192196009037	D-loop; other site
1192196009038	H-loop/switch region; other site
1192196009039	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1192196009040	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1192196009041	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196009042	Walker A/P-loop; other site
1192196009043	ATP binding site [chemical binding]; other site
1192196009044	Q-loop/lid; other site
1192196009045	ABC transporter signature motif; other site
1192196009046	Walker B; other site
1192196009047	D-loop; other site
1192196009048	H-loop/switch region; other site
1192196009049	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1192196009050	Ligand Binding Site [chemical binding]; other site
1192196009051	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1192196009052	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1192196009053	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1192196009054	homodimer interface [polypeptide binding]; other site
1192196009055	substrate-cofactor binding pocket; other site
1192196009056	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196009057	catalytic residue [active]
1192196009058	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1192196009059	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1192196009060	NodB motif; other site
1192196009061	active site
1192196009062	catalytic site [active]
1192196009063	Zn binding site [ion binding]; other site
1192196009064	NAD-dependent deacetylase; Provisional; Region: PRK00481
1192196009065	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
1192196009066	NAD+ binding site [chemical binding]; other site
1192196009067	substrate binding site [chemical binding]; other site
1192196009068	Zn binding site [ion binding]; other site
1192196009069	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1192196009070	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1192196009071	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
1192196009072	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1192196009073	active site
1192196009074	catalytic site [active]
1192196009075	metal binding site [ion binding]; metal-binding site
1192196009076	dimer interface [polypeptide binding]; other site
1192196009077	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1192196009078	camphor resistance protein CrcB; Provisional; Region: PRK14213
1192196009079	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1192196009080	Domain of unknown function DUF21; Region: DUF21; pfam01595
1192196009081	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1192196009082	Transporter associated domain; Region: CorC_HlyC; smart01091
1192196009083	aspartate aminotransferase; Provisional; Region: PRK06836
1192196009084	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196009085	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196009086	homodimer interface [polypeptide binding]; other site
1192196009087	catalytic residue [active]
1192196009088	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779
1192196009089	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1192196009090	DNA binding residues [nucleotide binding]
1192196009091	putative dimer interface [polypeptide binding]; other site
1192196009092	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1192196009093	Domain of unknown function DUF21; Region: DUF21; pfam01595
1192196009094	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1192196009095	Transporter associated domain; Region: CorC_HlyC; smart01091
1192196009096	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1192196009097	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1192196009098	putative acyl-acceptor binding pocket; other site
1192196009099	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1192196009100	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1192196009101	active site
1192196009102	catalytic tetrad [active]
1192196009103	RNA polymerase sigma factor SigM; Provisional; Region: PRK09644
1192196009104	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196009105	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196009106	DNA binding residues [nucleotide binding]
1192196009107	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
1192196009108	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
1192196009109	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1192196009110	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196009111	Coenzyme A binding pocket [chemical binding]; other site
1192196009112	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1192196009113	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196009114	DNA-binding site [nucleotide binding]; DNA binding site
1192196009115	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196009116	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196009117	homodimer interface [polypeptide binding]; other site
1192196009118	catalytic residue [active]
1192196009119	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1192196009120	Na2 binding site [ion binding]; other site
1192196009121	putative substrate binding site 1 [chemical binding]; other site
1192196009122	Na binding site 1 [ion binding]; other site
1192196009123	putative substrate binding site 2 [chemical binding]; other site
1192196009124	amino acid transporter; Region: 2A0306; TIGR00909
1192196009125	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1192196009126	short chain dehydrogenase; Provisional; Region: PRK06701
1192196009127	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1192196009128	NAD binding site [chemical binding]; other site
1192196009129	metal binding site [ion binding]; metal-binding site
1192196009130	active site
1192196009131	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
1192196009132	dimer interface [polypeptide binding]; other site
1192196009133	Citrate synthase; Region: Citrate_synt; pfam00285
1192196009134	active site
1192196009135	citrylCoA binding site [chemical binding]; other site
1192196009136	oxalacetate/citrate binding site [chemical binding]; other site
1192196009137	coenzyme A binding site [chemical binding]; other site
1192196009138	catalytic triad [active]
1192196009139	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196009140	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1192196009141	dimerization interface [polypeptide binding]; other site
1192196009142	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196009143	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196009144	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196009145	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1192196009146	NlpC/P60 family; Region: NLPC_P60; pfam00877
1192196009147	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1192196009148	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1192196009149	dimer interface [polypeptide binding]; other site
1192196009150	active site
1192196009151	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1192196009152	SpoVR like protein; Region: SpoVR; pfam04293
1192196009153	Conserved TM helix; Region: TM_helix; pfam05552
1192196009154	Conserved TM helix; Region: TM_helix; pfam05552
1192196009155	Conserved TM helix; Region: TM_helix; pfam05552
1192196009156	Conserved TM helix; Region: TM_helix; pfam05552
1192196009157	Transcriptional regulator; Region: Rrf2; cl17282
1192196009158	Rrf2 family protein; Region: rrf2_super; TIGR00738
1192196009159	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196009160	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196009161	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196009162	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196009163	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196009164	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1192196009165	NlpC/P60 family; Region: NLPC_P60; pfam00877
1192196009166	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
1192196009167	YhdB-like protein; Region: YhdB; pfam14148
1192196009168	Predicted flavoprotein [General function prediction only]; Region: COG0431
1192196009169	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1192196009170	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1192196009171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196009172	active site
1192196009173	phosphorylation site [posttranslational modification]
1192196009174	intermolecular recognition site; other site
1192196009175	dimerization interface [polypeptide binding]; other site
1192196009176	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1192196009177	DNA binding residues [nucleotide binding]
1192196009178	dimerization interface [polypeptide binding]; other site
1192196009179	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1192196009180	GAF domain; Region: GAF; pfam01590
1192196009181	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1192196009182	Histidine kinase; Region: HisKA_3; pfam07730
1192196009183	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196009184	ATP binding site [chemical binding]; other site
1192196009185	Mg2+ binding site [ion binding]; other site
1192196009186	G-X-G motif; other site
1192196009187	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1192196009188	active site
1192196009189	substrate binding site [chemical binding]; other site
1192196009190	metal binding site [ion binding]; metal-binding site
1192196009191	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1192196009192	glycerol kinase; Provisional; Region: glpK; PRK00047
1192196009193	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1192196009194	N- and C-terminal domain interface [polypeptide binding]; other site
1192196009195	active site
1192196009196	MgATP binding site [chemical binding]; other site
1192196009197	catalytic site [active]
1192196009198	metal binding site [ion binding]; metal-binding site
1192196009199	glycerol binding site [chemical binding]; other site
1192196009200	homotetramer interface [polypeptide binding]; other site
1192196009201	homodimer interface [polypeptide binding]; other site
1192196009202	FBP binding site [chemical binding]; other site
1192196009203	protein IIAGlc interface [polypeptide binding]; other site
1192196009204	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1192196009205	amphipathic channel; other site
1192196009206	Asn-Pro-Ala signature motifs; other site
1192196009207	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
1192196009208	aminotransferase; Validated; Region: PRK07678
1192196009209	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1192196009210	inhibitor-cofactor binding pocket; inhibition site
1192196009211	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196009212	catalytic residue [active]
1192196009213	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196009214	Coenzyme A binding pocket [chemical binding]; other site
1192196009215	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1192196009216	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
1192196009217	putative active site [active]
1192196009218	catalytic triad [active]
1192196009219	putative dimer interface [polypeptide binding]; other site
1192196009220	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1192196009221	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196009222	motif II; other site
1192196009223	FOG: CBS domain [General function prediction only]; Region: COG0517
1192196009224	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1192196009225	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1192196009226	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1192196009227	RNA binding surface [nucleotide binding]; other site
1192196009228	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1192196009229	active site
1192196009230	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
1192196009231	active site
1192196009232	catalytic site [active]
1192196009233	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1192196009234	generic binding surface II; other site
1192196009235	generic binding surface I; other site
1192196009236	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1192196009237	generic binding surface II; other site
1192196009238	generic binding surface I; other site
1192196009239	Staphylococcal nuclease homologues; Region: SNc; smart00318
1192196009240	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1192196009241	Catalytic site; other site
1192196009242	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1192196009243	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1192196009244	putative active site [active]
1192196009245	putative metal binding site [ion binding]; other site
1192196009246	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1192196009247	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1192196009248	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1192196009249	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
1192196009250	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
1192196009251	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1192196009252	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1192196009253	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1192196009254	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1192196009255	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1192196009256	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1192196009257	metal binding site [ion binding]; metal-binding site
1192196009258	active site
1192196009259	I-site; other site
1192196009260	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1192196009261	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1192196009262	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1192196009263	DNA-binding site [nucleotide binding]; DNA binding site
1192196009264	RNA-binding motif; other site
1192196009265	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1192196009266	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1192196009267	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1192196009268	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196009269	Walker A/P-loop; other site
1192196009270	ATP binding site [chemical binding]; other site
1192196009271	Q-loop/lid; other site
1192196009272	ABC transporter signature motif; other site
1192196009273	Walker B; other site
1192196009274	D-loop; other site
1192196009275	H-loop/switch region; other site
1192196009276	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1192196009277	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1192196009278	Walker A/P-loop; other site
1192196009279	ATP binding site [chemical binding]; other site
1192196009280	Q-loop/lid; other site
1192196009281	ABC transporter signature motif; other site
1192196009282	Walker B; other site
1192196009283	D-loop; other site
1192196009284	H-loop/switch region; other site
1192196009285	Predicted transcriptional regulators [Transcription]; Region: COG1725
1192196009286	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196009287	DNA-binding site [nucleotide binding]; DNA binding site
1192196009288	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1192196009289	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1192196009290	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1192196009291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196009292	putative substrate translocation pore; other site
1192196009293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196009294	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1192196009295	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1192196009296	carboxyltransferase (CT) interaction site; other site
1192196009297	biotinylation site [posttranslational modification]; other site
1192196009298	HlyD family secretion protein; Region: HlyD_3; pfam13437
1192196009299	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196009300	MarR family; Region: MarR; pfam01047
1192196009301	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
1192196009302	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
1192196009303	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1192196009304	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
1192196009305	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1192196009306	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
1192196009307	Protein of unknown function (DUF4004); Region: DUF4004; pfam13171
1192196009308	tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185
1192196009309	Putative amidase domain; Region: Amidase_6; pfam12671
1192196009310	epoxyqueuosine reductase; Region: TIGR00276
1192196009311	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1192196009312	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
1192196009313	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1192196009314	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1192196009315	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1192196009316	active site
1192196009317	dimer interface [polypeptide binding]; other site
1192196009318	non-prolyl cis peptide bond; other site
1192196009319	insertion regions; other site
1192196009320	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1192196009321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196009322	dimer interface [polypeptide binding]; other site
1192196009323	conserved gate region; other site
1192196009324	putative PBP binding loops; other site
1192196009325	ABC-ATPase subunit interface; other site
1192196009326	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1192196009327	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1192196009328	substrate binding pocket [chemical binding]; other site
1192196009329	membrane-bound complex binding site; other site
1192196009330	hinge residues; other site
1192196009331	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1192196009332	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1192196009333	Walker A/P-loop; other site
1192196009334	ATP binding site [chemical binding]; other site
1192196009335	Q-loop/lid; other site
1192196009336	ABC transporter signature motif; other site
1192196009337	Walker B; other site
1192196009338	D-loop; other site
1192196009339	H-loop/switch region; other site
1192196009340	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1192196009341	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1192196009342	tetramer interface [polypeptide binding]; other site
1192196009343	heme binding pocket [chemical binding]; other site
1192196009344	NADPH binding site [chemical binding]; other site
1192196009345	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
1192196009346	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1192196009347	Berberine and berberine like; Region: BBE; pfam08031
1192196009348	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
1192196009349	active site pocket [active]
1192196009350	oxyanion hole [active]
1192196009351	catalytic triad [active]
1192196009352	active site nucleophile [active]
1192196009353	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
1192196009354	SpoOM protein; Region: Spo0M; pfam07070
1192196009355	Protein of unknown function (DUF2614); Region: DUF2614; pfam11023
1192196009356	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1192196009357	metal binding site 2 [ion binding]; metal-binding site
1192196009358	putative DNA binding helix; other site
1192196009359	metal binding site 1 [ion binding]; metal-binding site
1192196009360	dimer interface [polypeptide binding]; other site
1192196009361	structural Zn2+ binding site [ion binding]; other site
1192196009362	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1192196009363	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1192196009364	catalytic triad [active]
1192196009365	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
1192196009366	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1192196009367	inhibitor-cofactor binding pocket; inhibition site
1192196009368	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196009369	catalytic residue [active]
1192196009370	Predicted membrane protein [Function unknown]; Region: COG4129
1192196009371	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1192196009372	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1192196009373	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1192196009374	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1192196009375	Walker A/P-loop; other site
1192196009376	ATP binding site [chemical binding]; other site
1192196009377	Q-loop/lid; other site
1192196009378	ABC transporter signature motif; other site
1192196009379	Walker B; other site
1192196009380	D-loop; other site
1192196009381	H-loop/switch region; other site
1192196009382	hypothetical protein; Provisional; Region: PRK13662
1192196009383	YgaB-like protein; Region: YgaB; pfam14182
1192196009384	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
1192196009385	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
1192196009386	putative NAD(P) binding site [chemical binding]; other site
1192196009387	active site
1192196009388	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
1192196009389	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1192196009390	minor groove reading motif; other site
1192196009391	helix-hairpin-helix signature motif; other site
1192196009392	substrate binding pocket [chemical binding]; other site
1192196009393	active site
1192196009394	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1192196009395	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1192196009396	DNA binding and oxoG recognition site [nucleotide binding]
1192196009397	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1192196009398	Predicted membrane protein [Function unknown]; Region: COG4485
1192196009399	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1192196009400	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1192196009401	Ligand binding site; other site
1192196009402	Putative Catalytic site; other site
1192196009403	DXD motif; other site
1192196009404	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1192196009405	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1192196009406	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1192196009407	catalytic site [active]
1192196009408	Predicted integral membrane protein [Function unknown]; Region: COG5658
1192196009409	SdpI/YhfL protein family; Region: SdpI; pfam13630
1192196009410	Bacterial SH3 domain; Region: SH3_3; pfam08239
1192196009411	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1192196009412	WVELL protein; Region: WVELL; pfam14043
1192196009413	Small acid-soluble spore protein K family; Region: SspK; pfam08176
1192196009414	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1192196009415	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196009416	putative substrate translocation pore; other site
1192196009417	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
1192196009418	recombination regulator RecX; Provisional; Region: recX; PRK14135
1192196009419	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1192196009420	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1192196009421	putative NAD(P) binding site [chemical binding]; other site
1192196009422	putative active site [active]
1192196009423	YfhD-like protein; Region: YfhD; pfam14151
1192196009424	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1192196009425	putative FMN binding site [chemical binding]; other site
1192196009426	phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654
1192196009427	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1192196009428	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196009429	ABC-ATPase subunit  interface; other site
1192196009430	dimer interface [polypeptide binding]; other site
1192196009431	putative PBP binding regions; other site
1192196009432	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1192196009433	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196009434	ABC-ATPase subunit  interface; other site
1192196009435	dimer interface [polypeptide binding]; other site
1192196009436	putative PBP binding regions; other site
1192196009437	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1192196009438	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1192196009439	siderophore binding site; other site
1192196009440	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1192196009441	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1192196009442	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196009443	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196009444	putative Zn2+ binding site [ion binding]; other site
1192196009445	putative DNA binding site [nucleotide binding]; other site
1192196009446	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196009447	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196009448	putative substrate translocation pore; other site
1192196009449	metal-dependent hydrolase; Provisional; Region: PRK13291
1192196009450	DinB superfamily; Region: DinB_2; pfam12867
1192196009451	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
1192196009452	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1192196009453	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1192196009454	Lipase (class 2); Region: Lipase_2; pfam01674
1192196009455	Predicted transcriptional regulators [Transcription]; Region: COG1695
1192196009456	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1192196009457	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1192196009458	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1192196009459	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1192196009460	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1192196009461	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1192196009462	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1192196009463	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1192196009464	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196009465	Walker A/P-loop; other site
1192196009466	ATP binding site [chemical binding]; other site
1192196009467	Q-loop/lid; other site
1192196009468	ABC transporter signature motif; other site
1192196009469	Walker B; other site
1192196009470	D-loop; other site
1192196009471	H-loop/switch region; other site
1192196009472	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1192196009473	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196009474	active site
1192196009475	phosphorylation site [posttranslational modification]
1192196009476	intermolecular recognition site; other site
1192196009477	dimerization interface [polypeptide binding]; other site
1192196009478	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1192196009479	DNA binding residues [nucleotide binding]
1192196009480	dimerization interface [polypeptide binding]; other site
1192196009481	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1192196009482	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1192196009483	Histidine kinase; Region: HisKA_3; pfam07730
1192196009484	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196009485	ATP binding site [chemical binding]; other site
1192196009486	Mg2+ binding site [ion binding]; other site
1192196009487	G-X-G motif; other site
1192196009488	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1192196009489	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1192196009490	putative metal binding site [ion binding]; other site
1192196009491	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1192196009492	active site
1192196009493	Predicted membrane protein [Function unknown]; Region: COG2259
1192196009494	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1192196009495	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1192196009496	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1192196009497	Walker A/P-loop; other site
1192196009498	ATP binding site [chemical binding]; other site
1192196009499	Q-loop/lid; other site
1192196009500	ABC transporter signature motif; other site
1192196009501	Walker B; other site
1192196009502	D-loop; other site
1192196009503	H-loop/switch region; other site
1192196009504	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1192196009505	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1192196009506	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196009507	Walker A/P-loop; other site
1192196009508	ATP binding site [chemical binding]; other site
1192196009509	Q-loop/lid; other site
1192196009510	ABC transporter signature motif; other site
1192196009511	Walker B; other site
1192196009512	D-loop; other site
1192196009513	H-loop/switch region; other site
1192196009514	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1192196009515	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
1192196009516	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1192196009517	active site turn [active]
1192196009518	phosphorylation site [posttranslational modification]
1192196009519	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1192196009520	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1192196009521	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1192196009522	putative active site [active]
1192196009523	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1192196009524	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
1192196009525	NAD binding site [chemical binding]; other site
1192196009526	sugar binding site [chemical binding]; other site
1192196009527	divalent metal binding site [ion binding]; other site
1192196009528	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1192196009529	dimer interface [polypeptide binding]; other site
1192196009530	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1192196009531	hypothetical protein; Provisional; Region: PRK02237
1192196009532	acid-soluble spore protein H; Provisional; Region: sspH; PRK03174
1192196009533	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1192196009534	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196009535	Walker A motif; other site
1192196009536	ATP binding site [chemical binding]; other site
1192196009537	Walker B motif; other site
1192196009538	arginine finger; other site
1192196009539	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1192196009540	dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912
1192196009541	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1192196009542	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1192196009543	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1192196009544	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1192196009545	E3 interaction surface; other site
1192196009546	lipoyl attachment site [posttranslational modification]; other site
1192196009547	e3 binding domain; Region: E3_binding; pfam02817
1192196009548	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1192196009549	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1192196009550	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1192196009551	alpha subunit interface [polypeptide binding]; other site
1192196009552	TPP binding site [chemical binding]; other site
1192196009553	heterodimer interface [polypeptide binding]; other site
1192196009554	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1192196009555	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1192196009556	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1192196009557	tetramer interface [polypeptide binding]; other site
1192196009558	TPP-binding site [chemical binding]; other site
1192196009559	heterodimer interface [polypeptide binding]; other site
1192196009560	phosphorylation loop region [posttranslational modification]
1192196009561	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1192196009562	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1192196009563	FMN binding site [chemical binding]; other site
1192196009564	active site
1192196009565	catalytic residues [active]
1192196009566	substrate binding site [chemical binding]; other site
1192196009567	YfzA-like protein; Region: YfzA; pfam14118
1192196009568	TRAM domain; Region: TRAM; pfam01938
1192196009569	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
1192196009570	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196009571	S-adenosylmethionine binding site [chemical binding]; other site
1192196009572	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1192196009573	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1192196009574	minor groove reading motif; other site
1192196009575	helix-hairpin-helix signature motif; other site
1192196009576	substrate binding pocket [chemical binding]; other site
1192196009577	active site
1192196009578	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1192196009579	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
1192196009580	oligomer interface [polypeptide binding]; other site
1192196009581	metal binding site [ion binding]; metal-binding site
1192196009582	metal binding site [ion binding]; metal-binding site
1192196009583	putative Cl binding site [ion binding]; other site
1192196009584	aspartate ring; other site
1192196009585	basic sphincter; other site
1192196009586	hydrophobic gate; other site
1192196009587	periplasmic entrance; other site
1192196009588	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1192196009589	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1192196009590	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
1192196009591	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
1192196009592	NodB motif; other site
1192196009593	active site
1192196009594	catalytic site [active]
1192196009595	Cd binding site [ion binding]; other site
1192196009596	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1192196009597	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196009598	FeS/SAM binding site; other site
1192196009599	YfkB-like domain; Region: YfkB; pfam08756
1192196009600	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1192196009601	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1192196009602	YfkD-like protein; Region: YfkD; pfam14167
1192196009603	calcium/proton exchanger (cax); Region: cax; TIGR00378
1192196009604	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1192196009605	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1192196009606	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196009607	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196009608	putative substrate translocation pore; other site
1192196009609	YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765
1192196009610	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1192196009611	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1192196009612	active site
1192196009613	Protein of unknown function (DUF1128); Region: DUF1128; pfam06569
1192196009614	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196009615	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196009616	putative substrate translocation pore; other site
1192196009617	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1192196009618	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1192196009619	proposed catalytic triad [active]
1192196009620	conserved cys residue [active]
1192196009621	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419
1192196009622	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1192196009623	active site
1192196009624	metal binding site [ion binding]; metal-binding site
1192196009625	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1192196009626	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
1192196009627	active site
1192196009628	metal binding site [ion binding]; metal-binding site
1192196009629	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1192196009630	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1192196009631	dimer interface [polypeptide binding]; other site
1192196009632	FMN binding site [chemical binding]; other site
1192196009633	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1192196009634	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196009635	DNA-binding site [nucleotide binding]; DNA binding site
1192196009636	UTRA domain; Region: UTRA; pfam07702
1192196009637	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1192196009638	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1192196009639	Ca binding site [ion binding]; other site
1192196009640	active site
1192196009641	catalytic site [active]
1192196009642	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1192196009643	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1192196009644	active site turn [active]
1192196009645	phosphorylation site [posttranslational modification]
1192196009646	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1192196009647	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1192196009648	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1192196009649	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1192196009650	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
1192196009651	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1192196009652	Sulfatase; Region: Sulfatase; pfam00884
1192196009653	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1192196009654	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1192196009655	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1192196009656	active site turn [active]
1192196009657	phosphorylation site [posttranslational modification]
1192196009658	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1192196009659	active site
1192196009660	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
1192196009661	Protein of unknown function (DUF2639); Region: DUF2639; pfam11121
1192196009662	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1192196009663	MOSC domain; Region: MOSC; pfam03473
1192196009664	3-alpha domain; Region: 3-alpha; pfam03475
1192196009665	acylphosphatase; Provisional; Region: PRK14420
1192196009666	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
1192196009667	active site
1192196009668	dimer interface [polypeptide binding]; other site
1192196009669	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1192196009670	citrate transporter, CitMHS family; Region: citMHS; TIGR00784
1192196009671	Citrate transporter; Region: CitMHS; pfam03600
1192196009672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1192196009673	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1192196009674	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196009675	active site
1192196009676	phosphorylation site [posttranslational modification]
1192196009677	intermolecular recognition site; other site
1192196009678	dimerization interface [polypeptide binding]; other site
1192196009679	Transcriptional regulator; Region: CitT; pfam12431
1192196009680	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1192196009681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196009682	ATP binding site [chemical binding]; other site
1192196009683	Mg2+ binding site [ion binding]; other site
1192196009684	G-X-G motif; other site
1192196009685	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1192196009686	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1192196009687	transmembrane helices; other site
1192196009688	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1192196009689	Amb_all domain; Region: Amb_all; smart00656
1192196009690	Heat induced stress protein YflT; Region: YflT; pfam11181
1192196009691	Protein of unknown function (DUF3212); Region: DUF3212; pfam11486
1192196009692	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1192196009693	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1192196009694	siderophore binding site; other site
1192196009695	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1192196009696	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196009697	ABC-ATPase subunit  interface; other site
1192196009698	dimer interface [polypeptide binding]; other site
1192196009699	putative PBP binding regions; other site
1192196009700	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1192196009701	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196009702	ABC-ATPase subunit  interface; other site
1192196009703	dimer interface [polypeptide binding]; other site
1192196009704	putative PBP binding regions; other site
1192196009705	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1192196009706	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1192196009707	Walker A/P-loop; other site
1192196009708	ATP binding site [chemical binding]; other site
1192196009709	Q-loop/lid; other site
1192196009710	ABC transporter signature motif; other site
1192196009711	Walker B; other site
1192196009712	D-loop; other site
1192196009713	H-loop/switch region; other site
1192196009714	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1192196009715	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1192196009716	H+ Antiporter protein; Region: 2A0121; TIGR00900
1192196009717	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196009718	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1192196009719	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1192196009720	NAD(P) binding site [chemical binding]; other site
1192196009721	substrate binding site [chemical binding]; other site
1192196009722	dimer interface [polypeptide binding]; other site
1192196009723	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1192196009724	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1192196009725	Coenzyme A binding pocket [chemical binding]; other site
1192196009726	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1192196009727	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1192196009728	ATP binding site [chemical binding]; other site
1192196009729	Mg++ binding site [ion binding]; other site
1192196009730	motif III; other site
1192196009731	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1192196009732	nucleotide binding region [chemical binding]; other site
1192196009733	ATP-binding site [chemical binding]; other site
1192196009734	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1192196009735	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1192196009736	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1192196009737	ABC transporter; Region: ABC_tran_2; pfam12848
1192196009738	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1192196009739	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1192196009740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196009741	putative substrate translocation pore; other site
1192196009742	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1192196009743	Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774
1192196009744	DNA binding residues [nucleotide binding]
1192196009745	putative dimer interface [polypeptide binding]; other site
1192196009746	Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787
1192196009747	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1192196009748	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196009749	Walker A/P-loop; other site
1192196009750	ATP binding site [chemical binding]; other site
1192196009751	Q-loop/lid; other site
1192196009752	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1192196009753	ABC transporter signature motif; other site
1192196009754	Walker B; other site
1192196009755	D-loop; other site
1192196009756	ABC transporter; Region: ABC_tran_2; pfam12848
1192196009757	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1192196009758	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1192196009759	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1192196009760	dimer interface [polypeptide binding]; other site
1192196009761	putative CheW interface [polypeptide binding]; other site
1192196009762	NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151
1192196009763	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1192196009764	NAD(P) binding site [chemical binding]; other site
1192196009765	catalytic residues [active]
1192196009766	amino acid transporter; Region: 2A0306; TIGR00909
1192196009767	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1192196009768	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1192196009769	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196009770	active site
1192196009771	motif I; other site
1192196009772	motif II; other site
1192196009773	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196009774	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196009775	putative substrate translocation pore; other site
1192196009776	Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407
1192196009777	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1192196009778	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1192196009779	active site
1192196009780	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1192196009781	Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407
1192196009782	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1192196009783	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1192196009784	NAD(P) binding site [chemical binding]; other site
1192196009785	active site
1192196009786	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1192196009787	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
1192196009788	substrate binding site; other site
1192196009789	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1192196009790	Sulfatase; Region: Sulfatase; pfam00884
1192196009791	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1192196009792	Cytochrome P450; Region: p450; pfam00067
1192196009793	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1192196009794	Flavodoxin; Region: Flavodoxin_1; pfam00258
1192196009795	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
1192196009796	FAD binding pocket [chemical binding]; other site
1192196009797	FAD binding motif [chemical binding]; other site
1192196009798	catalytic residues [active]
1192196009799	NAD binding pocket [chemical binding]; other site
1192196009800	phosphate binding motif [ion binding]; other site
1192196009801	beta-alpha-beta structure motif; other site
1192196009802	Protein of unknown function (DUF3900); Region: DUF3900; pfam13039
1192196009803	Domain of unknown function (DUF3898); Region: DUF3898; pfam13037
1192196009804	hypothetical protein; Provisional; Region: PRK06847
1192196009805	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1192196009806	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196009807	MarR family; Region: MarR; pfam01047
1192196009808	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1192196009809	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1192196009810	Uncharacterized small protein [Function unknown]; Region: COG5583
1192196009811	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1192196009812	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196009813	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1192196009814	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1192196009815	Predicted membrane protein [Function unknown]; Region: COG2323
1192196009816	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1192196009817	NAD(P) binding site [chemical binding]; other site
1192196009818	substrate binding site [chemical binding]; other site
1192196009819	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1192196009820	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196009821	dimer interface [polypeptide binding]; other site
1192196009822	conserved gate region; other site
1192196009823	putative PBP binding loops; other site
1192196009824	ABC-ATPase subunit interface; other site
1192196009825	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1192196009826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1192196009827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196009828	dimer interface [polypeptide binding]; other site
1192196009829	putative PBP binding loops; other site
1192196009830	ABC-ATPase subunit interface; other site
1192196009831	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1192196009832	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1192196009833	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1192196009834	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1192196009835	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1192196009836	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1192196009837	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1192196009838	active site
1192196009839	catalytic triad [active]
1192196009840	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1192196009841	metal binding site [ion binding]; metal-binding site
1192196009842	active site
1192196009843	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1192196009844	metal binding site [ion binding]; metal-binding site
1192196009845	active site
1192196009846	Predicted integral membrane protein [Function unknown]; Region: COG5578
1192196009847	Domain of unknown function (DUF1961); Region: DUF1961; pfam09224
1192196009848	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1192196009849	active site
1192196009850	catalytic triad [active]
1192196009851	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1192196009852	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1192196009853	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1192196009854	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1192196009855	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196009856	dimer interface [polypeptide binding]; other site
1192196009857	conserved gate region; other site
1192196009858	putative PBP binding loops; other site
1192196009859	ABC-ATPase subunit interface; other site
1192196009860	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1192196009861	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196009862	dimer interface [polypeptide binding]; other site
1192196009863	conserved gate region; other site
1192196009864	putative PBP binding loops; other site
1192196009865	ABC-ATPase subunit interface; other site
1192196009866	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1192196009867	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1192196009868	Response regulator receiver domain; Region: Response_reg; pfam00072
1192196009869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196009870	active site
1192196009871	phosphorylation site [posttranslational modification]
1192196009872	intermolecular recognition site; other site
1192196009873	dimerization interface [polypeptide binding]; other site
1192196009874	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1192196009875	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1192196009876	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1192196009877	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196009878	dimerization interface [polypeptide binding]; other site
1192196009879	Histidine kinase; Region: His_kinase; pfam06580
1192196009880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196009881	ATP binding site [chemical binding]; other site
1192196009882	Mg2+ binding site [ion binding]; other site
1192196009883	G-X-G motif; other site
1192196009884	Predicted integral membrane protein [Function unknown]; Region: COG5578
1192196009885	YesK-like protein; Region: YesK; pfam14150
1192196009886	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196009887	Coenzyme A binding pocket [chemical binding]; other site
1192196009888	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1192196009889	dimanganese center [ion binding]; other site
1192196009890	CotJB protein; Region: CotJB; pfam12652
1192196009891	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
1192196009892	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1192196009893	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1192196009894	NADP binding site [chemical binding]; other site
1192196009895	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1192196009896	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196009897	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196009898	hypothetical protein; Provisional; Region: PRK12378
1192196009899	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196009900	binding surface
1192196009901	TPR motif; other site
1192196009902	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1192196009903	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1192196009904	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196009905	TPR motif; other site
1192196009906	binding surface
1192196009907	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1192196009908	Uncharacterized conserved protein [Function unknown]; Region: COG5444
1192196009909	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
1192196009910	Protein of unknown function, DUF600; Region: DUF600; cl04640
1192196009911	Protein of unknown function, DUF600; Region: DUF600; cl04640
1192196009912	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
1192196009913	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
1192196009914	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1192196009915	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1192196009916	ATP binding site [chemical binding]; other site
1192196009917	putative Mg++ binding site [ion binding]; other site
1192196009918	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1192196009919	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1192196009920	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1192196009921	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1192196009922	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196009923	S-adenosylmethionine binding site [chemical binding]; other site
1192196009924	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
1192196009925	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
1192196009926	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196009927	S-adenosylmethionine binding site [chemical binding]; other site
1192196009928	putative lipid kinase; Reviewed; Region: PRK13337
1192196009929	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1192196009930	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1192196009931	Protein export membrane protein; Region: SecD_SecF; cl14618
1192196009932	Protein export membrane protein; Region: SecD_SecF; cl14618
1192196009933	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196009934	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196009935	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1192196009936	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1192196009937	GatB domain; Region: GatB_Yqey; pfam02637
1192196009938	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1192196009939	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1192196009940	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1192196009941	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1192196009942	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1192196009943	Na binding site [ion binding]; other site
1192196009944	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1192196009945	MgtC family; Region: MgtC; pfam02308
1192196009946	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1192196009947	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1192196009948	active site
1192196009949	ATP binding site [chemical binding]; other site
1192196009950	substrate binding site [chemical binding]; other site
1192196009951	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
1192196009952	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1192196009953	putative dimer interface [polypeptide binding]; other site
1192196009954	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1192196009955	putative dimer interface [polypeptide binding]; other site
1192196009956	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1192196009957	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1192196009958	nucleotide binding pocket [chemical binding]; other site
1192196009959	K-X-D-G motif; other site
1192196009960	catalytic site [active]
1192196009961	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1192196009962	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1192196009963	Helix-hairpin-helix motif; Region: HHH; pfam00633
1192196009964	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1192196009965	Dimer interface [polypeptide binding]; other site
1192196009966	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1192196009967	Part of AAA domain; Region: AAA_19; pfam13245
1192196009968	Family description; Region: UvrD_C_2; pfam13538
1192196009969	PcrB family; Region: PcrB; pfam01884
1192196009970	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
1192196009971	substrate binding site [chemical binding]; other site
1192196009972	putative active site [active]
1192196009973	dimer interface [polypeptide binding]; other site
1192196009974	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1192196009975	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1192196009976	active site
1192196009977	FMN binding site [chemical binding]; other site
1192196009978	substrate binding site [chemical binding]; other site
1192196009979	3Fe-4S cluster binding site [ion binding]; other site
1192196009980	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
1192196009981	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
1192196009982	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1192196009983	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1192196009984	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1192196009985	active site
1192196009986	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1192196009987	putative transporter; Provisional; Region: PRK11021
1192196009988	Spore germination protein; Region: Spore_permease; cl17796
1192196009989	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1192196009990	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196009991	putative DNA binding site [nucleotide binding]; other site
1192196009992	putative Zn2+ binding site [ion binding]; other site
1192196009993	AsnC family; Region: AsnC_trans_reg; pfam01037
1192196009994	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1192196009995	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1192196009996	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1192196009997	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1192196009998	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1192196009999	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1192196010000	purine monophosphate binding site [chemical binding]; other site
1192196010001	dimer interface [polypeptide binding]; other site
1192196010002	putative catalytic residues [active]
1192196010003	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1192196010004	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1192196010005	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1192196010006	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1192196010007	active site
1192196010008	substrate binding site [chemical binding]; other site
1192196010009	cosubstrate binding site; other site
1192196010010	catalytic site [active]
1192196010011	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1192196010012	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1192196010013	dimerization interface [polypeptide binding]; other site
1192196010014	putative ATP binding site [chemical binding]; other site
1192196010015	amidophosphoribosyltransferase; Provisional; Region: PRK07631
1192196010016	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1192196010017	active site
1192196010018	tetramer interface [polypeptide binding]; other site
1192196010019	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1192196010020	active site
1192196010021	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1192196010022	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1192196010023	dimerization interface [polypeptide binding]; other site
1192196010024	ATP binding site [chemical binding]; other site
1192196010025	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1192196010026	dimerization interface [polypeptide binding]; other site
1192196010027	ATP binding site [chemical binding]; other site
1192196010028	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1192196010029	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1192196010030	putative active site [active]
1192196010031	catalytic triad [active]
1192196010032	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1192196010033	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1192196010034	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1192196010035	ATP binding site [chemical binding]; other site
1192196010036	active site
1192196010037	substrate binding site [chemical binding]; other site
1192196010038	adenylosuccinate lyase; Provisional; Region: PRK07492
1192196010039	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1192196010040	tetramer interface [polypeptide binding]; other site
1192196010041	active site
1192196010042	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1192196010043	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1192196010044	NAD binding site [chemical binding]; other site
1192196010045	ATP-grasp domain; Region: ATP-grasp; pfam02222
1192196010046	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1192196010047	NETI protein; Region: NETI; pfam14044
1192196010048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
1192196010049	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1192196010050	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1192196010051	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
1192196010052	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
1192196010053	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196010054	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196010055	DNA binding residues [nucleotide binding]
1192196010056	GMP synthase; Reviewed; Region: guaA; PRK00074
1192196010057	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1192196010058	AMP/PPi binding site [chemical binding]; other site
1192196010059	candidate oxyanion hole; other site
1192196010060	catalytic triad [active]
1192196010061	potential glutamine specificity residues [chemical binding]; other site
1192196010062	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1192196010063	ATP Binding subdomain [chemical binding]; other site
1192196010064	Ligand Binding sites [chemical binding]; other site
1192196010065	Dimerization subdomain; other site
1192196010066	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1192196010067	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1192196010068	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1192196010069	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1192196010070	Protein of unknown function DUF58; Region: DUF58; pfam01882
1192196010071	MoxR-like ATPases [General function prediction only]; Region: COG0714
1192196010072	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196010073	Walker A motif; other site
1192196010074	ATP binding site [chemical binding]; other site
1192196010075	Walker B motif; other site
1192196010076	arginine finger; other site
1192196010077	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1192196010078	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1192196010079	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
1192196010080	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1192196010081	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1192196010082	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1192196010083	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1192196010084	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
1192196010085	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1192196010086	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1192196010087	Cold-inducible protein YdjO; Region: YdjO; pfam14169
1192196010088	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1192196010089	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1192196010090	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
1192196010091	putative NAD(P) binding site [chemical binding]; other site
1192196010092	catalytic Zn binding site [ion binding]; other site
1192196010093	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010094	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1192196010095	putative substrate translocation pore; other site
1192196010096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010097	Ion channel; Region: Ion_trans_2; pfam07885
1192196010098	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
1192196010099	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
1192196010100	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1192196010101	Double zinc ribbon; Region: DZR; pfam12773
1192196010102	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
1192196010103	Repair protein; Region: Repair_PSII; pfam04536
1192196010104	TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271
1192196010105	DNA-directed RNA polymerase subunit F; Provisional; Region: PRK14981
1192196010106	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1192196010107	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1192196010108	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1192196010109	putative substrate binding site [chemical binding]; other site
1192196010110	putative ATP binding site [chemical binding]; other site
1192196010111	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1192196010112	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010113	putative substrate translocation pore; other site
1192196010114	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1192196010115	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
1192196010116	inhibitor binding site; inhibition site
1192196010117	catalytic Zn binding site [ion binding]; other site
1192196010118	structural Zn binding site [ion binding]; other site
1192196010119	NADP binding site [chemical binding]; other site
1192196010120	tetramer interface [polypeptide binding]; other site
1192196010121	NB-ARC domain; Region: NB-ARC; pfam00931
1192196010122	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1192196010123	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196010124	TPR motif; other site
1192196010125	TPR repeat; Region: TPR_11; pfam13414
1192196010126	binding surface
1192196010127	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1192196010128	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
1192196010129	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1192196010130	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1192196010131	ring oligomerisation interface [polypeptide binding]; other site
1192196010132	ATP/Mg binding site [chemical binding]; other site
1192196010133	stacking interactions; other site
1192196010134	hinge regions; other site
1192196010135	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1192196010136	oligomerisation interface [polypeptide binding]; other site
1192196010137	mobile loop; other site
1192196010138	roof hairpin; other site
1192196010139	CAAX protease self-immunity; Region: Abi; pfam02517
1192196010140	Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945
1192196010141	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1192196010142	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1192196010143	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1192196010144	CoA binding domain; Region: CoA_binding; pfam02629
1192196010145	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1192196010146	trimer interface [polypeptide binding]; other site
1192196010147	dimer interface [polypeptide binding]; other site
1192196010148	putative active site [active]
1192196010149	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1192196010150	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1192196010151	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1192196010152	ABC transporter; Region: ABC_tran_2; pfam12848
1192196010153	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1192196010154	UGMP family protein; Validated; Region: PRK09604
1192196010155	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1192196010156	nucleotide binding site [chemical binding]; other site
1192196010157	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1192196010158	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196010159	Coenzyme A binding pocket [chemical binding]; other site
1192196010160	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1192196010161	Glycoprotease family; Region: Peptidase_M22; pfam00814
1192196010162	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1192196010163	thiamine-monophosphate kinase; Region: thiL; TIGR01379
1192196010164	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1192196010165	ATP binding site [chemical binding]; other site
1192196010166	dimerization interface [polypeptide binding]; other site
1192196010167	Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546
1192196010168	dinuclear metal binding motif [ion binding]; other site
1192196010169	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1192196010170	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1192196010171	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1192196010172	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1192196010173	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1192196010174	nucleotide binding site [chemical binding]; other site
1192196010175	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1192196010176	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196010177	DNA-binding site [nucleotide binding]; DNA binding site
1192196010178	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1192196010179	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1192196010180	beta-galactosidase; Region: BGL; TIGR03356
1192196010181	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1192196010182	PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410
1192196010183	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1192196010184	active site
1192196010185	methionine cluster; other site
1192196010186	phosphorylation site [posttranslational modification]
1192196010187	metal binding site [ion binding]; metal-binding site
1192196010188	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1192196010189	active site
1192196010190	P-loop; other site
1192196010191	phosphorylation site [posttranslational modification]
1192196010192	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1192196010193	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010194	putative substrate translocation pore; other site
1192196010195	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
1192196010196	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
1192196010197	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1192196010198	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1192196010199	Zn2+ binding site [ion binding]; other site
1192196010200	Mg2+ binding site [ion binding]; other site
1192196010201	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196010202	Coenzyme A binding pocket [chemical binding]; other site
1192196010203	Uncharacterized conserved protein [Function unknown]; Region: COG5646
1192196010204	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1192196010205	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1192196010206	dimer interface [polypeptide binding]; other site
1192196010207	active site
1192196010208	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1192196010209	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1192196010210	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1192196010211	active site
1192196010212	TDP-binding site; other site
1192196010213	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1192196010214	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196010215	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196010216	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1192196010217	active site
1192196010218	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1192196010219	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196010220	DNA-binding site [nucleotide binding]; DNA binding site
1192196010221	FCD domain; Region: FCD; pfam07729
1192196010222	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1192196010223	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1192196010224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010225	putative substrate translocation pore; other site
1192196010226	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196010227	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196010228	putative DNA binding site [nucleotide binding]; other site
1192196010229	putative Zn2+ binding site [ion binding]; other site
1192196010230	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1192196010231	dimer interface [polypeptide binding]; other site
1192196010232	FMN binding site [chemical binding]; other site
1192196010233	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1192196010234	MMPL family; Region: MMPL; pfam03176
1192196010235	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196010236	MarR family; Region: MarR; pfam01047
1192196010237	DinB family; Region: DinB; pfam05163
1192196010238	DinB superfamily; Region: DinB_2; pfam12867
1192196010239	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1192196010240	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1192196010241	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1192196010242	ABC transporter; Region: ABC_tran_2; pfam12848
1192196010243	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1192196010244	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1192196010245	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196010246	Coenzyme A binding pocket [chemical binding]; other site
1192196010247	DoxX-like family; Region: DoxX_2; pfam13564
1192196010248	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196010249	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196010250	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1192196010251	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1192196010252	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1192196010253	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1192196010254	putative dimer interface [polypeptide binding]; other site
1192196010255	Predicted membrane protein [Function unknown]; Region: COG2323
1192196010256	Predicted membrane protein [Function unknown]; Region: COG2323
1192196010257	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1192196010258	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1192196010259	catalytic residues [active]
1192196010260	Predicted membrane protein [Function unknown]; Region: COG2259
1192196010261	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1192196010262	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196010263	Zn binding site [ion binding]; other site
1192196010264	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1192196010265	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1192196010266	Zn binding site [ion binding]; other site
1192196010267	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1192196010268	dimer interface [polypeptide binding]; other site
1192196010269	FMN binding site [chemical binding]; other site
1192196010270	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1192196010271	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1192196010272	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1192196010273	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1192196010274	DNA binding residues [nucleotide binding]
1192196010275	drug binding residues [chemical binding]; other site
1192196010276	dimer interface [polypeptide binding]; other site
1192196010277	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
1192196010278	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
1192196010279	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1192196010280	MMPL family; Region: MMPL; pfam03176
1192196010281	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
1192196010282	MMPL family; Region: MMPL; pfam03176
1192196010283	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1192196010284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196010285	active site
1192196010286	phosphorylation site [posttranslational modification]
1192196010287	intermolecular recognition site; other site
1192196010288	dimerization interface [polypeptide binding]; other site
1192196010289	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1192196010290	DNA binding residues [nucleotide binding]
1192196010291	dimerization interface [polypeptide binding]; other site
1192196010292	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1192196010293	Histidine kinase; Region: HisKA_3; pfam07730
1192196010294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196010295	ATP binding site [chemical binding]; other site
1192196010296	Mg2+ binding site [ion binding]; other site
1192196010297	G-X-G motif; other site
1192196010298	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1192196010299	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
1192196010300	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196010301	putative DNA binding site [nucleotide binding]; other site
1192196010302	putative Zn2+ binding site [ion binding]; other site
1192196010303	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1192196010304	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1192196010305	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196010306	DNA-binding site [nucleotide binding]; DNA binding site
1192196010307	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196010308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196010309	homodimer interface [polypeptide binding]; other site
1192196010310	catalytic residue [active]
1192196010311	EamA-like transporter family; Region: EamA; pfam00892
1192196010312	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1192196010313	EamA-like transporter family; Region: EamA; pfam00892
1192196010314	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
1192196010315	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1192196010316	arsenical pump membrane protein; Provisional; Region: PRK15445
1192196010317	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1192196010318	transmembrane helices; other site
1192196010319	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196010320	dimerization interface [polypeptide binding]; other site
1192196010321	putative DNA binding site [nucleotide binding]; other site
1192196010322	putative Zn2+ binding site [ion binding]; other site
1192196010323	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196010324	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196010325	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1192196010326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010327	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1192196010328	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1192196010329	Predicted transcriptional regulators [Transcription]; Region: COG1733
1192196010330	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1192196010331	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1192196010332	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1192196010333	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1192196010334	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1192196010335	Predicted transcriptional regulators [Transcription]; Region: COG1733
1192196010336	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1192196010337	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1192196010338	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1192196010339	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
1192196010340	putative active site [active]
1192196010341	putative catalytic site [active]
1192196010342	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1192196010343	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196010344	DNA-binding site [nucleotide binding]; DNA binding site
1192196010345	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196010346	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196010347	homodimer interface [polypeptide binding]; other site
1192196010348	catalytic residue [active]
1192196010349	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196010350	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196010351	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1192196010352	dimerization domain swap beta strand [polypeptide binding]; other site
1192196010353	regulatory protein interface [polypeptide binding]; other site
1192196010354	regulatory phosphorylation site [posttranslational modification]; other site
1192196010355	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1192196010356	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1192196010357	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1192196010358	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1192196010359	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010360	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196010361	putative substrate translocation pore; other site
1192196010362	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1192196010363	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196010364	DNA-binding site [nucleotide binding]; DNA binding site
1192196010365	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196010366	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196010367	homodimer interface [polypeptide binding]; other site
1192196010368	catalytic residue [active]
1192196010369	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1192196010370	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1192196010371	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1192196010372	EamA-like transporter family; Region: EamA; pfam00892
1192196010373	EamA-like transporter family; Region: EamA; pfam00892
1192196010374	Cupin domain; Region: Cupin_2; pfam07883
1192196010375	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1192196010376	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1192196010377	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1192196010378	EamA-like transporter family; Region: EamA; pfam00892
1192196010379	EamA-like transporter family; Region: EamA; pfam00892
1192196010380	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1192196010381	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1192196010382	DNA-binding site [nucleotide binding]; DNA binding site
1192196010383	RNA-binding motif; other site
1192196010384	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1192196010385	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
1192196010386	conserved cys residue [active]
1192196010387	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1192196010388	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1192196010389	non-specific DNA binding site [nucleotide binding]; other site
1192196010390	salt bridge; other site
1192196010391	sequence-specific DNA binding site [nucleotide binding]; other site
1192196010392	Putative amidase domain; Region: Amidase_6; pfam12671
1192196010393	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1192196010394	active site
1192196010395	EVE domain; Region: EVE; cl00728
1192196010396	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1192196010397	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1192196010398	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
1192196010399	hypothetical protein; Provisional; Region: PRK04351
1192196010400	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1192196010401	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1192196010402	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1192196010403	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1192196010404	RNA binding site [nucleotide binding]; other site
1192196010405	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
1192196010406	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
1192196010407	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196010408	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1192196010409	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196010410	DNA binding residues [nucleotide binding]
1192196010411	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1192196010412	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196010413	ATP binding site [chemical binding]; other site
1192196010414	Mg2+ binding site [ion binding]; other site
1192196010415	G-X-G motif; other site
1192196010416	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1192196010417	anti sigma factor interaction site; other site
1192196010418	regulatory phosphorylation site [posttranslational modification]; other site
1192196010419	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1192196010420	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
1192196010421	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1192196010422	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1192196010423	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196010424	ATP binding site [chemical binding]; other site
1192196010425	Mg2+ binding site [ion binding]; other site
1192196010426	G-X-G motif; other site
1192196010427	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1192196010428	Rsbr N terminal; Region: Rsbr_N; pfam08678
1192196010429	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1192196010430	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1192196010431	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
1192196010432	ribbon-helix-helix domain containing protein; Region: PHA00617
1192196010433	alanine racemase; Region: alr; TIGR00492
1192196010434	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1192196010435	active site
1192196010436	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1192196010437	dimer interface [polypeptide binding]; other site
1192196010438	substrate binding site [chemical binding]; other site
1192196010439	catalytic residues [active]
1192196010440	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1192196010441	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
1192196010442	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1192196010443	Rhomboid family; Region: Rhomboid; pfam01694
1192196010444	Bacterial PH domain; Region: DUF304; pfam03703
1192196010445	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1192196010446	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1192196010447	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1192196010448	ATP binding site [chemical binding]; other site
1192196010449	Mg++ binding site [ion binding]; other site
1192196010450	motif III; other site
1192196010451	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1192196010452	nucleotide binding region [chemical binding]; other site
1192196010453	ATP-binding site [chemical binding]; other site
1192196010454	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1192196010455	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1192196010456	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1192196010457	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1192196010458	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1192196010459	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1192196010460	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1192196010461	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1192196010462	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1192196010463	catalytic residues [active]
1192196010464	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1192196010465	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1192196010466	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
1192196010467	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1192196010468	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1192196010469	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1192196010470	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1192196010471	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1192196010472	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1192196010473	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196010474	Walker A/P-loop; other site
1192196010475	ATP binding site [chemical binding]; other site
1192196010476	Q-loop/lid; other site
1192196010477	ABC transporter signature motif; other site
1192196010478	Walker B; other site
1192196010479	D-loop; other site
1192196010480	H-loop/switch region; other site
1192196010481	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1192196010482	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1192196010483	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1192196010484	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1192196010485	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1192196010486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196010487	active site
1192196010488	phosphorylation site [posttranslational modification]
1192196010489	intermolecular recognition site; other site
1192196010490	dimerization interface [polypeptide binding]; other site
1192196010491	HTH domain; Region: HTH_11; cl17392
1192196010492	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1192196010493	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1192196010494	putative active site [active]
1192196010495	heme pocket [chemical binding]; other site
1192196010496	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196010497	ATP binding site [chemical binding]; other site
1192196010498	Mg2+ binding site [ion binding]; other site
1192196010499	G-X-G motif; other site
1192196010500	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1192196010501	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
1192196010502	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1192196010503	dimanganese center [ion binding]; other site
1192196010504	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1192196010505	General stress protein [General function prediction only]; Region: GsiB; COG3729
1192196010506	EcsC protein family; Region: EcsC; pfam12787
1192196010507	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
1192196010508	Predicted membrane protein [Function unknown]; Region: COG2261
1192196010509	manganese transport protein MntH; Reviewed; Region: PRK00701
1192196010510	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1192196010511	pyruvate oxidase; Provisional; Region: PRK08611
1192196010512	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1192196010513	PYR/PP interface [polypeptide binding]; other site
1192196010514	tetramer interface [polypeptide binding]; other site
1192196010515	dimer interface [polypeptide binding]; other site
1192196010516	TPP binding site [chemical binding]; other site
1192196010517	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1192196010518	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1192196010519	TPP-binding site [chemical binding]; other site
1192196010520	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1192196010521	nudix motif; other site
1192196010522	Amino acid permease; Region: AA_permease_2; pfam13520
1192196010523	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
1192196010524	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
1192196010525	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1192196010526	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1192196010527	DXD motif; other site
1192196010528	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
1192196010529	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
1192196010530	NodB motif; other site
1192196010531	putative active site [active]
1192196010532	putative catalytic site [active]
1192196010533	putative Zn binding site [ion binding]; other site
1192196010534	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1192196010535	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1192196010536	metal binding site [ion binding]; metal-binding site
1192196010537	active site
1192196010538	I-site; other site
1192196010539	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
1192196010540	DNA topoisomerase III; Provisional; Region: PRK07726
1192196010541	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1192196010542	active site
1192196010543	putative interdomain interaction site [polypeptide binding]; other site
1192196010544	putative metal-binding site [ion binding]; other site
1192196010545	putative nucleotide binding site [chemical binding]; other site
1192196010546	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1192196010547	domain I; other site
1192196010548	DNA binding groove [nucleotide binding]
1192196010549	phosphate binding site [ion binding]; other site
1192196010550	domain II; other site
1192196010551	domain III; other site
1192196010552	nucleotide binding site [chemical binding]; other site
1192196010553	catalytic site [active]
1192196010554	domain IV; other site
1192196010555	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1192196010556	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1192196010557	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1192196010558	putative DNA binding site [nucleotide binding]; other site
1192196010559	putative Zn2+ binding site [ion binding]; other site
1192196010560	AsnC family; Region: AsnC_trans_reg; pfam01037
1192196010561	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1192196010562	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
1192196010563	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1192196010564	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1192196010565	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1192196010566	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1192196010567	ABC-type sugar transport system, auxiliary component [General function prediction only]; Region: COG3822
1192196010568	short chain dehydrogenase; Provisional; Region: PRK06701
1192196010569	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1192196010570	NAD binding site [chemical binding]; other site
1192196010571	metal binding site [ion binding]; metal-binding site
1192196010572	active site
1192196010573	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196010574	S-adenosylmethionine binding site [chemical binding]; other site
1192196010575	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1192196010576	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1192196010577	acyl-activating enzyme (AAE) consensus motif; other site
1192196010578	putative AMP binding site [chemical binding]; other site
1192196010579	putative active site [active]
1192196010580	putative CoA binding site [chemical binding]; other site
1192196010581	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1192196010582	HTH domain; Region: HTH_11; pfam08279
1192196010583	PRD domain; Region: PRD; pfam00874
1192196010584	PRD domain; Region: PRD; pfam00874
1192196010585	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1192196010586	active site
1192196010587	P-loop; other site
1192196010588	phosphorylation site [posttranslational modification]
1192196010589	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1192196010590	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1192196010591	active site
1192196010592	catalytic tetrad [active]
1192196010593	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1192196010594	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1192196010595	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1192196010596	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1192196010597	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1192196010598	Protein of unknown function (DUF3953); Region: DUF3953; pfam13129
1192196010599	Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755
1192196010600	active site
1192196010601	catalytic triad [active]
1192196010602	oxyanion hole [active]
1192196010603	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1192196010604	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1192196010605	Bacterial transcriptional regulator; Region: IclR; pfam01614
1192196010606	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1192196010607	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1192196010608	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1192196010609	hypothetical protein; Provisional; Region: PRK05463
1192196010610	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1192196010611	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1192196010612	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1192196010613	putative active site [active]
1192196010614	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1192196010615	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196010616	active site
1192196010617	motif I; other site
1192196010618	motif II; other site
1192196010619	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1192196010620	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1192196010621	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1192196010622	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1192196010623	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1192196010624	Catalytic site [active]
1192196010625	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1192196010626	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1192196010627	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1192196010628	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1192196010629	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1192196010630	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1192196010631	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1192196010632	active site
1192196010633	P-loop; other site
1192196010634	phosphorylation site [posttranslational modification]
1192196010635	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1192196010636	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1192196010637	NosL; Region: NosL; cl01769
1192196010638	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
1192196010639	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
1192196010640	YtkA-like; Region: YtkA; pfam13115
1192196010641	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1192196010642	glucose-1-dehydrogenase; Provisional; Region: PRK08936
1192196010643	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
1192196010644	NAD binding site [chemical binding]; other site
1192196010645	homodimer interface [polypeptide binding]; other site
1192196010646	active site
1192196010647	Sugar transport protein; Region: Sugar_transport; pfam06800
1192196010648	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
1192196010649	succinic semialdehyde dehydrogenase; Region: PLN02278
1192196010650	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1192196010651	tetramerization interface [polypeptide binding]; other site
1192196010652	NAD(P) binding site [chemical binding]; other site
1192196010653	catalytic residues [active]
1192196010654	4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918
1192196010655	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1192196010656	inhibitor-cofactor binding pocket; inhibition site
1192196010657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196010658	catalytic residue [active]
1192196010659	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1192196010660	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196010661	DNA-binding site [nucleotide binding]; DNA binding site
1192196010662	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196010663	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196010664	homodimer interface [polypeptide binding]; other site
1192196010665	catalytic residue [active]
1192196010666	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196010667	dimerization interface [polypeptide binding]; other site
1192196010668	putative DNA binding site [nucleotide binding]; other site
1192196010669	putative Zn2+ binding site [ion binding]; other site
1192196010670	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1192196010671	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1192196010672	dimer interface [polypeptide binding]; other site
1192196010673	FMN binding site [chemical binding]; other site
1192196010674	NADPH bind site [chemical binding]; other site
1192196010675	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196010676	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196010677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010678	putative substrate translocation pore; other site
1192196010679	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010680	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1192196010681	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1192196010682	putative ligand binding residues [chemical binding]; other site
1192196010683	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1192196010684	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1192196010685	Walker A/P-loop; other site
1192196010686	ATP binding site [chemical binding]; other site
1192196010687	Q-loop/lid; other site
1192196010688	ABC transporter signature motif; other site
1192196010689	Walker B; other site
1192196010690	D-loop; other site
1192196010691	H-loop/switch region; other site
1192196010692	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196010693	ABC-ATPase subunit  interface; other site
1192196010694	dimer interface [polypeptide binding]; other site
1192196010695	putative PBP binding regions; other site
1192196010696	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1192196010697	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196010698	ABC-ATPase subunit  interface; other site
1192196010699	dimer interface [polypeptide binding]; other site
1192196010700	putative PBP binding regions; other site
1192196010701	aspartate kinase; Reviewed; Region: PRK09034
1192196010702	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1192196010703	putative catalytic residues [active]
1192196010704	putative nucleotide binding site [chemical binding]; other site
1192196010705	putative aspartate binding site [chemical binding]; other site
1192196010706	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1192196010707	allosteric regulatory residue; other site
1192196010708	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1192196010709	Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131
1192196010710	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1192196010711	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196010712	TPR motif; other site
1192196010713	binding surface
1192196010714	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1192196010715	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1192196010716	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196010717	dimerization interface [polypeptide binding]; other site
1192196010718	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196010719	dimer interface [polypeptide binding]; other site
1192196010720	phosphorylation site [posttranslational modification]
1192196010721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196010722	ATP binding site [chemical binding]; other site
1192196010723	Mg2+ binding site [ion binding]; other site
1192196010724	G-X-G motif; other site
1192196010725	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1192196010726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196010727	dimerization interface [polypeptide binding]; other site
1192196010728	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1192196010729	DNA binding site [nucleotide binding]
1192196010730	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1192196010731	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1192196010732	FtsX-like permease family; Region: FtsX; pfam02687
1192196010733	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1192196010734	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1192196010735	Walker A/P-loop; other site
1192196010736	ATP binding site [chemical binding]; other site
1192196010737	Q-loop/lid; other site
1192196010738	ABC transporter signature motif; other site
1192196010739	Walker B; other site
1192196010740	D-loop; other site
1192196010741	H-loop/switch region; other site
1192196010742	Spore germination protein; Region: Spore_permease; pfam03845
1192196010743	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1192196010744	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1192196010745	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1192196010746	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1192196010747	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
1192196010748	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1192196010749	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010750	putative substrate translocation pore; other site
1192196010751	POT family; Region: PTR2; pfam00854
1192196010752	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1192196010753	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1192196010754	UbiD family decarboxylase; Region: TIGR00148
1192196010755	polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421
1192196010756	Flavoprotein; Region: Flavoprotein; pfam02441
1192196010757	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196010758	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196010759	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1192196010760	dimerization interface [polypeptide binding]; other site
1192196010761	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1192196010762	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1192196010763	substrate binding pocket [chemical binding]; other site
1192196010764	membrane-bound complex binding site; other site
1192196010765	hinge residues; other site
1192196010766	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1192196010767	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196010768	dimer interface [polypeptide binding]; other site
1192196010769	conserved gate region; other site
1192196010770	putative PBP binding loops; other site
1192196010771	ABC-ATPase subunit interface; other site
1192196010772	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1192196010773	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1192196010774	Walker A/P-loop; other site
1192196010775	ATP binding site [chemical binding]; other site
1192196010776	Q-loop/lid; other site
1192196010777	ABC transporter signature motif; other site
1192196010778	Walker B; other site
1192196010779	D-loop; other site
1192196010780	H-loop/switch region; other site
1192196010781	Predicted membrane protein [Function unknown]; Region: COG2364
1192196010782	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1192196010783	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1192196010784	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
1192196010785	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1192196010786	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196010787	DNA-binding site [nucleotide binding]; DNA binding site
1192196010788	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1192196010789	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196010790	homodimer interface [polypeptide binding]; other site
1192196010791	catalytic residue [active]
1192196010792	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1192196010793	EamA-like transporter family; Region: EamA; pfam00892
1192196010794	EamA-like transporter family; Region: EamA; pfam00892
1192196010795	YcxB-like protein; Region: YcxB; pfam14317
1192196010796	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196010797	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1192196010798	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
1192196010799	Condensation domain; Region: Condensation; pfam00668
1192196010800	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1192196010801	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1192196010802	acyl-activating enzyme (AAE) consensus motif; other site
1192196010803	AMP binding site [chemical binding]; other site
1192196010804	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1192196010805	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1192196010806	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1192196010807	Predicted transcriptional regulators [Transcription]; Region: COG1733
1192196010808	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1192196010809	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1192196010810	active site
1192196010811	dimer interface [polypeptide binding]; other site
1192196010812	magnesium binding site [ion binding]; other site
1192196010813	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1192196010814	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
1192196010815	tetramer interface [polypeptide binding]; other site
1192196010816	active site
1192196010817	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1192196010818	dimerization interface [polypeptide binding]; other site
1192196010819	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1192196010820	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1192196010821	dimer interface [polypeptide binding]; other site
1192196010822	putative CheW interface [polypeptide binding]; other site
1192196010823	Competence protein J (ComJ); Region: ComJ; pfam11033
1192196010824	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1192196010825	beta-galactosidase; Region: BGL; TIGR03356
1192196010826	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196010827	Walker A/P-loop; other site
1192196010828	ATP binding site [chemical binding]; other site
1192196010829	Q-loop/lid; other site
1192196010830	ABC transporter signature motif; other site
1192196010831	Walker B; other site
1192196010832	D-loop; other site
1192196010833	H-loop/switch region; other site
1192196010834	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196010835	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196010836	putative DNA binding site [nucleotide binding]; other site
1192196010837	putative Zn2+ binding site [ion binding]; other site
1192196010838	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
1192196010839	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1192196010840	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1192196010841	substrate binding pocket [chemical binding]; other site
1192196010842	membrane-bound complex binding site; other site
1192196010843	hinge residues; other site
1192196010844	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1192196010845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196010846	dimer interface [polypeptide binding]; other site
1192196010847	conserved gate region; other site
1192196010848	putative PBP binding loops; other site
1192196010849	ABC-ATPase subunit interface; other site
1192196010850	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1192196010851	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1192196010852	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1192196010853	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1192196010854	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1192196010855	Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642
1192196010856	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1192196010857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010858	putative substrate translocation pore; other site
1192196010859	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
1192196010860	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1192196010861	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1192196010862	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1192196010863	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1192196010864	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1192196010865	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1192196010866	[4Fe-4S] binding site [ion binding]; other site
1192196010867	molybdopterin cofactor binding site; other site
1192196010868	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
1192196010869	molybdopterin cofactor binding site; other site
1192196010870	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
1192196010871	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1192196010872	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1192196010873	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1192196010874	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1192196010875	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1192196010876	[2Fe-2S] cluster binding site [ion binding]; other site
1192196010877	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1192196010878	active site
1192196010879	SAM binding site [chemical binding]; other site
1192196010880	homodimer interface [polypeptide binding]; other site
1192196010881	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1192196010882	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1192196010883	active site
1192196010884	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1192196010885	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1192196010886	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1192196010887	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1192196010888	Predicted permeases [General function prediction only]; Region: COG0701
1192196010889	Predicted membrane protein [Function unknown]; Region: COG3689
1192196010890	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1192196010891	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1192196010892	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1192196010893	Na binding site [ion binding]; other site
1192196010894	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1192196010895	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1192196010896	Glutamate binding site [chemical binding]; other site
1192196010897	homodimer interface [polypeptide binding]; other site
1192196010898	NAD binding site [chemical binding]; other site
1192196010899	catalytic residues [active]
1192196010900	Proline dehydrogenase; Region: Pro_dh; pfam01619
1192196010901	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
1192196010902	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
1192196010903	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1192196010904	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1192196010905	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1192196010906	dimerization interface [polypeptide binding]; other site
1192196010907	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196010908	S-adenosylmethionine binding site [chemical binding]; other site
1192196010909	shikimate kinase; Reviewed; Region: aroK; PRK00131
1192196010910	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1192196010911	ADP binding site [chemical binding]; other site
1192196010912	magnesium binding site [ion binding]; other site
1192196010913	putative shikimate binding site; other site
1192196010914	AAA domain; Region: AAA_33; pfam13671
1192196010915	NAD+ synthetase; Region: nadE; TIGR00552
1192196010916	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1192196010917	homodimer interface [polypeptide binding]; other site
1192196010918	NAD binding pocket [chemical binding]; other site
1192196010919	ATP binding pocket [chemical binding]; other site
1192196010920	Mg binding site [ion binding]; other site
1192196010921	active-site loop [active]
1192196010922	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
1192196010923	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1192196010924	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1192196010925	Spore germination protein; Region: Spore_permease; cl17796
1192196010926	Uncharacterized conserved protein [Function unknown]; Region: COG3403
1192196010927	LysE type translocator; Region: LysE; pfam01810
1192196010928	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196010929	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196010930	putative DNA binding site [nucleotide binding]; other site
1192196010931	putative Zn2+ binding site [ion binding]; other site
1192196010932	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010933	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196010934	putative substrate translocation pore; other site
1192196010935	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010936	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1192196010937	L-lactate permease; Region: Lactate_perm; pfam02652
1192196010938	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1192196010939	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1192196010940	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1192196010941	NAD binding site [chemical binding]; other site
1192196010942	dimer interface [polypeptide binding]; other site
1192196010943	substrate binding site [chemical binding]; other site
1192196010944	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315
1192196010945	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1192196010946	active site
1192196010947	Ca binding site [ion binding]; other site
1192196010948	catalytic site [active]
1192196010949	Aamy_C domain; Region: Aamy_C; smart00632
1192196010950	Predicted membrane protein [Function unknown]; Region: COG1288
1192196010951	M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018
1192196010952	amidohydrolase; Region: amidohydrolases; TIGR01891
1192196010953	metal binding site [ion binding]; metal-binding site
1192196010954	putative dimer interface [polypeptide binding]; other site
1192196010955	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1192196010956	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1192196010957	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1192196010958	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
1192196010959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1192196010960	dimer interface [polypeptide binding]; other site
1192196010961	conserved gate region; other site
1192196010962	putative PBP binding loops; other site
1192196010963	ABC-ATPase subunit interface; other site
1192196010964	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196010965	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1192196010966	Walker A/P-loop; other site
1192196010967	ATP binding site [chemical binding]; other site
1192196010968	Q-loop/lid; other site
1192196010969	ABC transporter signature motif; other site
1192196010970	Walker B; other site
1192196010971	D-loop; other site
1192196010972	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196010973	dimerization interface [polypeptide binding]; other site
1192196010974	putative DNA binding site [nucleotide binding]; other site
1192196010975	putative Zn2+ binding site [ion binding]; other site
1192196010976	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1192196010977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010978	putative substrate translocation pore; other site
1192196010979	benzoate transport; Region: 2A0115; TIGR00895
1192196010980	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196010981	putative substrate translocation pore; other site
1192196010982	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
1192196010983	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
1192196010984	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1192196010985	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1192196010986	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1192196010987	putative metal binding site [ion binding]; other site
1192196010988	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1192196010989	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1192196010990	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1192196010991	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1192196010992	putative metal binding site [ion binding]; other site
1192196010993	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1192196010994	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1192196010995	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1192196010996	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1192196010997	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196010998	ABC-ATPase subunit  interface; other site
1192196010999	dimer interface [polypeptide binding]; other site
1192196011000	putative PBP binding regions; other site
1192196011001	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1192196011002	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1192196011003	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1192196011004	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1192196011005	metal binding site [ion binding]; metal-binding site
1192196011006	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1192196011007	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1192196011008	Ca binding site [ion binding]; other site
1192196011009	active site
1192196011010	catalytic site [active]
1192196011011	glucose-1-dehydrogenase; Provisional; Region: PRK08936
1192196011012	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
1192196011013	NAD binding site [chemical binding]; other site
1192196011014	homodimer interface [polypeptide binding]; other site
1192196011015	active site
1192196011016	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196011017	binding surface
1192196011018	TPR motif; other site
1192196011019	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1192196011020	TPR motif; other site
1192196011021	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1192196011022	binding surface
1192196011023	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
1192196011024	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1192196011025	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1192196011026	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1192196011027	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1192196011028	active site
1192196011029	catalytic tetrad [active]
1192196011030	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1192196011031	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1192196011032	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1192196011033	ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266
1192196011034	Walker A/P-loop; other site
1192196011035	ATP binding site [chemical binding]; other site
1192196011036	Q-loop/lid; other site
1192196011037	ABC transporter signature motif; other site
1192196011038	Walker B; other site
1192196011039	D-loop; other site
1192196011040	H-loop/switch region; other site
1192196011041	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1192196011042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196011043	active site
1192196011044	phosphorylation site [posttranslational modification]
1192196011045	intermolecular recognition site; other site
1192196011046	dimerization interface [polypeptide binding]; other site
1192196011047	LytTr DNA-binding domain; Region: LytTR; pfam04397
1192196011048	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1192196011049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196011050	ATP binding site [chemical binding]; other site
1192196011051	Mg2+ binding site [ion binding]; other site
1192196011052	G-X-G motif; other site
1192196011053	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
1192196011054	helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225
1192196011055	Predicted membrane protein/domain [Function unknown]; Region: COG1714
1192196011056	Lipase (class 2); Region: Lipase_2; pfam01674
1192196011057	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1192196011058	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1192196011059	active site
1192196011060	homotetramer interface [polypeptide binding]; other site
1192196011061	homodimer interface [polypeptide binding]; other site
1192196011062	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1192196011063	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1192196011064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196011065	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196011066	putative substrate translocation pore; other site
1192196011067	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196011068	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1192196011069	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1192196011070	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1192196011071	catalytic residue [active]
1192196011072	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1192196011073	putative substrate binding pocket [chemical binding]; other site
1192196011074	AC domain interface; other site
1192196011075	catalytic triad [active]
1192196011076	AB domain interface; other site
1192196011077	interchain disulfide; other site
1192196011078	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1192196011079	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1192196011080	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1192196011081	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1192196011082	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
1192196011083	metal ion-dependent adhesion site (MIDAS); other site
1192196011084	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
1192196011085	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1192196011086	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
1192196011087	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1192196011088	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1192196011089	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1192196011090	Walker A/P-loop; other site
1192196011091	ATP binding site [chemical binding]; other site
1192196011092	Q-loop/lid; other site
1192196011093	ABC transporter signature motif; other site
1192196011094	Walker B; other site
1192196011095	D-loop; other site
1192196011096	H-loop/switch region; other site
1192196011097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1192196011098	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196011099	dimer interface [polypeptide binding]; other site
1192196011100	phosphorylation site [posttranslational modification]
1192196011101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196011102	ATP binding site [chemical binding]; other site
1192196011103	Mg2+ binding site [ion binding]; other site
1192196011104	G-X-G motif; other site
1192196011105	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1192196011106	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196011107	active site
1192196011108	phosphorylation site [posttranslational modification]
1192196011109	intermolecular recognition site; other site
1192196011110	dimerization interface [polypeptide binding]; other site
1192196011111	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1192196011112	DNA binding site [nucleotide binding]
1192196011113	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1192196011114	EamA-like transporter family; Region: EamA; pfam00892
1192196011115	anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748
1192196011116	dodecamer interface 1 [polypeptide binding]; other site
1192196011117	dodecamer interface 2 [polypeptide binding]; other site
1192196011118	trimer interface [polypeptide binding]; other site
1192196011119	TRAP binding interface [polypeptide binding]; other site
1192196011120	Zn binding site [ion binding]; other site
1192196011121	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
1192196011122	putative active site [active]
1192196011123	putative substrate binding site [chemical binding]; other site
1192196011124	Phosphotransferase enzyme family; Region: APH; pfam01636
1192196011125	ATP binding site [chemical binding]; other site
1192196011126	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1192196011127	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1192196011128	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1192196011129	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1192196011130	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196011131	DNA-binding site [nucleotide binding]; DNA binding site
1192196011132	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1192196011133	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1192196011134	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1192196011135	active site
1192196011136	tetramer interface [polypeptide binding]; other site
1192196011137	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196011138	D-galactonate transporter; Region: 2A0114; TIGR00893
1192196011139	putative substrate translocation pore; other site
1192196011140	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1192196011141	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
1192196011142	NAD(P) binding site [chemical binding]; other site
1192196011143	catalytic residues [active]
1192196011144	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
1192196011145	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1192196011146	putative active site [active]
1192196011147	catalytic residue [active]
1192196011148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196011149	Response regulator receiver domain; Region: Response_reg; pfam00072
1192196011150	active site
1192196011151	phosphorylation site [posttranslational modification]
1192196011152	intermolecular recognition site; other site
1192196011153	dimerization interface [polypeptide binding]; other site
1192196011154	YcbB domain; Region: YcbB; pfam08664
1192196011155	Chorismate mutase type II; Region: CM_2; cl00693
1192196011156	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1192196011157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196011158	ATP binding site [chemical binding]; other site
1192196011159	Mg2+ binding site [ion binding]; other site
1192196011160	G-X-G motif; other site
1192196011161	glutaminase; Reviewed; Region: PRK12357
1192196011162	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1192196011163	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1192196011164	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1192196011165	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
1192196011166	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1192196011167	S-methylmethionine transporter; Provisional; Region: PRK11387
1192196011168	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1192196011169	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1192196011170	homodimer interface [polypeptide binding]; other site
1192196011171	substrate-cofactor binding pocket; other site
1192196011172	catalytic residue [active]
1192196011173	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1192196011174	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1192196011175	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1192196011176	DNA-binding site [nucleotide binding]; DNA binding site
1192196011177	UTRA domain; Region: UTRA; pfam07702
1192196011178	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1192196011179	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1192196011180	active site
1192196011181	trimer interface [polypeptide binding]; other site
1192196011182	allosteric site; other site
1192196011183	active site lid [active]
1192196011184	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1192196011185	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1192196011186	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1192196011187	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1192196011188	active site turn [active]
1192196011189	phosphorylation site [posttranslational modification]
1192196011190	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1192196011191	HPr interaction site; other site
1192196011192	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1192196011193	active site
1192196011194	phosphorylation site [posttranslational modification]
1192196011195	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1192196011196	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1192196011197	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1192196011198	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1192196011199	active site residue [active]
1192196011200	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1192196011201	Erythromycin esterase homolog [General function prediction only]; Region: COG2312
1192196011202	phosphatidylserine decarboxylase; Provisional; Region: PRK03140
1192196011203	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1192196011204	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1192196011205	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1192196011206	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
1192196011207	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1192196011208	Protein of unknown function (DUF2606); Region: DUF2606; pfam10794
1192196011209	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1192196011210	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1192196011211	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1192196011212	ATP-grasp domain; Region: ATP-grasp; pfam02222
1192196011213	LXG domain of WXG superfamily; Region: LXG; pfam04740
1192196011214	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233
1192196011215	active site
1192196011216	conformational flexibility of ligand binding pocket; other site
1192196011217	ADP-ribosylating toxin turn-turn motif; other site
1192196011218	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
1192196011219	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1192196011220	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1192196011221	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1192196011222	EamA-like transporter family; Region: EamA; pfam00892
1192196011223	EamA-like transporter family; Region: EamA; pfam00892
1192196011224	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1192196011225	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1192196011226	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1192196011227	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1192196011228	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
1192196011229	active site
1192196011230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196011231	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1192196011232	putative substrate translocation pore; other site
1192196011233	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1192196011234	MarR family; Region: MarR; pfam01047
1192196011235	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
1192196011236	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1192196011237	Coenzyme A binding pocket [chemical binding]; other site
1192196011238	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
1192196011239	glycerol-3-phosphate transporter; Region: glpT; TIGR00712
1192196011240	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196011241	putative substrate translocation pore; other site
1192196011242	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196011243	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1192196011244	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
1192196011245	active site
1192196011246	catalytic site [active]
1192196011247	metal binding site [ion binding]; metal-binding site
1192196011248	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1192196011249	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1192196011250	Cytochrome P450; Region: p450; cl12078
1192196011251	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1192196011252	putative transport protein YifK; Provisional; Region: PRK10746
1192196011253	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1192196011254	active site
1192196011255	ATP binding site [chemical binding]; other site
1192196011256	substrate binding site [chemical binding]; other site
1192196011257	activation loop (A-loop); other site
1192196011258	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1192196011259	HAMP domain; Region: HAMP; pfam00672
1192196011260	dimerization interface [polypeptide binding]; other site
1192196011261	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1192196011262	dimer interface [polypeptide binding]; other site
1192196011263	phosphorylation site [posttranslational modification]
1192196011264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196011265	ATP binding site [chemical binding]; other site
1192196011266	Mg2+ binding site [ion binding]; other site
1192196011267	G-X-G motif; other site
1192196011268	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1192196011269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1192196011270	active site
1192196011271	phosphorylation site [posttranslational modification]
1192196011272	intermolecular recognition site; other site
1192196011273	dimerization interface [polypeptide binding]; other site
1192196011274	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1192196011275	DNA binding site [nucleotide binding]
1192196011276	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1192196011277	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1192196011278	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1192196011279	catalytic residues [active]
1192196011280	HEAT repeats; Region: HEAT_2; pfam13646
1192196011281	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1192196011282	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1192196011283	Walker A/P-loop; other site
1192196011284	ATP binding site [chemical binding]; other site
1192196011285	Q-loop/lid; other site
1192196011286	ABC transporter signature motif; other site
1192196011287	Walker B; other site
1192196011288	D-loop; other site
1192196011289	H-loop/switch region; other site
1192196011290	CAAX protease self-immunity; Region: Abi; pfam02517
1192196011291	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1192196011292	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1192196011293	FeS/SAM binding site; other site
1192196011294	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449
1192196011295	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1192196011296	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1192196011297	putative substrate translocation pore; other site
1192196011298	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1192196011299	dimerization interface [polypeptide binding]; other site
1192196011300	putative DNA binding site [nucleotide binding]; other site
1192196011301	putative Zn2+ binding site [ion binding]; other site
1192196011302	Uncharacterized conserved protein [Function unknown]; Region: COG5609
1192196011303	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288
1192196011304	dimer interface [polypeptide binding]; other site
1192196011305	zinc binding site [ion binding]; other site
1192196011306	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
1192196011307	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
1192196011308	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
1192196011309	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1192196011310	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1192196011311	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1192196011312	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1192196011313	DNA binding site [nucleotide binding]
1192196011314	active site
1192196011315	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1192196011316	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1192196011317	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1192196011318	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1192196011319	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
1192196011320	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1192196011321	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1192196011322	minor groove reading motif; other site
1192196011323	helix-hairpin-helix signature motif; other site
1192196011324	substrate binding pocket [chemical binding]; other site
1192196011325	active site
1192196011326	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1192196011327	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1192196011328	glutaminase active site [active]
1192196011329	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1192196011330	dimer interface [polypeptide binding]; other site
1192196011331	active site
1192196011332	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1192196011333	dimer interface [polypeptide binding]; other site
1192196011334	active site
1192196011335	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1192196011336	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1192196011337	active site
1192196011338	substrate binding site [chemical binding]; other site
1192196011339	metal binding site [ion binding]; metal-binding site
1192196011340	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1192196011341	YbbR-like protein; Region: YbbR; pfam07949
1192196011342	YbbR-like protein; Region: YbbR; pfam07949
1192196011343	YbbR-like protein; Region: YbbR; pfam07949
1192196011344	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1192196011345	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1192196011346	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1192196011347	Putative zinc-finger; Region: zf-HC2; pfam13490
1192196011348	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1192196011349	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
1192196011350	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196011351	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1192196011352	DNA binding residues [nucleotide binding]
1192196011353	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1192196011354	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
1192196011355	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1192196011356	putative active site [active]
1192196011357	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1192196011358	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1192196011359	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1192196011360	putative active site [active]
1192196011361	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1192196011362	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1192196011363	active site turn [active]
1192196011364	phosphorylation site [posttranslational modification]
1192196011365	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1192196011366	putative periplasmic esterase; Provisional; Region: PRK03642
1192196011367	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1192196011368	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1192196011369	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1192196011370	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1192196011371	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876
1192196011372	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1192196011373	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1192196011374	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1192196011375	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1192196011376	putative ligand binding residues [chemical binding]; other site
1192196011377	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1192196011378	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1192196011379	putative ligand binding residues [chemical binding]; other site
1192196011380	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1192196011381	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1192196011382	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196011383	ABC-ATPase subunit  interface; other site
1192196011384	dimer interface [polypeptide binding]; other site
1192196011385	putative PBP binding regions; other site
1192196011386	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1192196011387	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1192196011388	ABC-ATPase subunit  interface; other site
1192196011389	dimer interface [polypeptide binding]; other site
1192196011390	putative PBP binding regions; other site
1192196011391	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1192196011392	bile acid transporter; Region: bass; TIGR00841
1192196011393	Sodium Bile acid symporter family; Region: SBF; cl17470
1192196011394	Sodium Bile acid symporter family; Region: SBF; cl17470
1192196011395	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1192196011396	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1192196011397	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1192196011398	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1192196011399	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1192196011400	Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949
1192196011401	NodB motif; other site
1192196011402	putative active site [active]
1192196011403	putative catalytic site [active]
1192196011404	KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089
1192196011405	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1192196011406	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1192196011407	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1192196011408	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1192196011409	active site
1192196011410	metal binding site [ion binding]; metal-binding site
1192196011411	Protein of unknown function (DUF2521); Region: DUF2521; pfam10730
1192196011412	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1192196011413	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196011414	S-adenosylmethionine binding site [chemical binding]; other site
1192196011415	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1192196011416	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1192196011417	23S rRNA interface [nucleotide binding]; other site
1192196011418	L3 interface [polypeptide binding]; other site
1192196011419	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1192196011420	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1192196011421	dimerization interface 3.5A [polypeptide binding]; other site
1192196011422	active site
1192196011423	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1192196011424	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
1192196011425	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1192196011426	Walker A/P-loop; other site
1192196011427	ATP binding site [chemical binding]; other site
1192196011428	Q-loop/lid; other site
1192196011429	ABC transporter signature motif; other site
1192196011430	Walker B; other site
1192196011431	D-loop; other site
1192196011432	H-loop/switch region; other site
1192196011433	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
1192196011434	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1192196011435	Walker A/P-loop; other site
1192196011436	ATP binding site [chemical binding]; other site
1192196011437	Q-loop/lid; other site
1192196011438	ABC transporter signature motif; other site
1192196011439	Walker B; other site
1192196011440	D-loop; other site
1192196011441	H-loop/switch region; other site
1192196011442	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1192196011443	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1192196011444	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1192196011445	alphaNTD homodimer interface [polypeptide binding]; other site
1192196011446	alphaNTD - beta interaction site [polypeptide binding]; other site
1192196011447	alphaNTD - beta' interaction site [polypeptide binding]; other site
1192196011448	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1192196011449	30S ribosomal protein S11; Validated; Region: PRK05309
1192196011450	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1192196011451	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1192196011452	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1192196011453	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1192196011454	rRNA binding site [nucleotide binding]; other site
1192196011455	predicted 30S ribosome binding site; other site
1192196011456	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1192196011457	active site
1192196011458	adenylate kinase; Reviewed; Region: adk; PRK00279
1192196011459	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1192196011460	AMP-binding site [chemical binding]; other site
1192196011461	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1192196011462	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1192196011463	SecY translocase; Region: SecY; pfam00344
1192196011464	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1192196011465	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1192196011466	23S rRNA binding site [nucleotide binding]; other site
1192196011467	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1192196011468	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1192196011469	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1192196011470	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1192196011471	5S rRNA interface [nucleotide binding]; other site
1192196011472	L27 interface [polypeptide binding]; other site
1192196011473	23S rRNA interface [nucleotide binding]; other site
1192196011474	L5 interface [polypeptide binding]; other site
1192196011475	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1192196011476	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1192196011477	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1192196011478	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1192196011479	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1192196011480	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1192196011481	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1192196011482	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1192196011483	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1192196011484	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1192196011485	RNA binding site [nucleotide binding]; other site
1192196011486	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1192196011487	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1192196011488	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1192196011489	23S rRNA interface [nucleotide binding]; other site
1192196011490	putative translocon interaction site; other site
1192196011491	signal recognition particle (SRP54) interaction site; other site
1192196011492	L23 interface [polypeptide binding]; other site
1192196011493	trigger factor interaction site; other site
1192196011494	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1192196011495	23S rRNA interface [nucleotide binding]; other site
1192196011496	5S rRNA interface [nucleotide binding]; other site
1192196011497	putative antibiotic binding site [chemical binding]; other site
1192196011498	L25 interface [polypeptide binding]; other site
1192196011499	L27 interface [polypeptide binding]; other site
1192196011500	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1192196011501	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1192196011502	G-X-X-G motif; other site
1192196011503	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1192196011504	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1192196011505	putative translocon binding site; other site
1192196011506	protein-rRNA interface [nucleotide binding]; other site
1192196011507	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1192196011508	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1192196011509	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1192196011510	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1192196011511	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1192196011512	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1192196011513	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1192196011514	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1192196011515	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1192196011516	elongation factor Tu; Reviewed; Region: PRK00049
1192196011517	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1192196011518	G1 box; other site
1192196011519	GEF interaction site [polypeptide binding]; other site
1192196011520	GTP/Mg2+ binding site [chemical binding]; other site
1192196011521	Switch I region; other site
1192196011522	G2 box; other site
1192196011523	G3 box; other site
1192196011524	Switch II region; other site
1192196011525	G4 box; other site
1192196011526	G5 box; other site
1192196011527	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1192196011528	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1192196011529	Antibiotic Binding Site [chemical binding]; other site
1192196011530	elongation factor G; Reviewed; Region: PRK00007
1192196011531	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1192196011532	G1 box; other site
1192196011533	putative GEF interaction site [polypeptide binding]; other site
1192196011534	GTP/Mg2+ binding site [chemical binding]; other site
1192196011535	Switch I region; other site
1192196011536	G2 box; other site
1192196011537	G3 box; other site
1192196011538	Switch II region; other site
1192196011539	G4 box; other site
1192196011540	G5 box; other site
1192196011541	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1192196011542	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1192196011543	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1192196011544	30S ribosomal protein S7; Validated; Region: PRK05302
1192196011545	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1192196011546	S17 interaction site [polypeptide binding]; other site
1192196011547	S8 interaction site; other site
1192196011548	16S rRNA interaction site [nucleotide binding]; other site
1192196011549	streptomycin interaction site [chemical binding]; other site
1192196011550	23S rRNA interaction site [nucleotide binding]; other site
1192196011551	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1192196011552	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
1192196011553	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1192196011554	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1192196011555	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1192196011556	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1192196011557	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1192196011558	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1192196011559	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1192196011560	G-loop; other site
1192196011561	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1192196011562	DNA binding site [nucleotide binding]
1192196011563	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1192196011564	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1192196011565	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1192196011566	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1192196011567	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1192196011568	RPB1 interaction site [polypeptide binding]; other site
1192196011569	RPB10 interaction site [polypeptide binding]; other site
1192196011570	RPB11 interaction site [polypeptide binding]; other site
1192196011571	RPB3 interaction site [polypeptide binding]; other site
1192196011572	RPB12 interaction site [polypeptide binding]; other site
1192196011573	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1192196011574	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196011575	S-adenosylmethionine binding site [chemical binding]; other site
1192196011576	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1192196011577	core dimer interface [polypeptide binding]; other site
1192196011578	peripheral dimer interface [polypeptide binding]; other site
1192196011579	L10 interface [polypeptide binding]; other site
1192196011580	L11 interface [polypeptide binding]; other site
1192196011581	putative EF-Tu interaction site [polypeptide binding]; other site
1192196011582	putative EF-G interaction site [polypeptide binding]; other site
1192196011583	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1192196011584	23S rRNA interface [nucleotide binding]; other site
1192196011585	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1192196011586	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1192196011587	mRNA/rRNA interface [nucleotide binding]; other site
1192196011588	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1192196011589	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1192196011590	23S rRNA interface [nucleotide binding]; other site
1192196011591	L7/L12 interface [polypeptide binding]; other site
1192196011592	putative thiostrepton binding site; other site
1192196011593	L25 interface [polypeptide binding]; other site
1192196011594	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1192196011595	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1192196011596	putative homodimer interface [polypeptide binding]; other site
1192196011597	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1192196011598	heterodimer interface [polypeptide binding]; other site
1192196011599	homodimer interface [polypeptide binding]; other site
1192196011600	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1192196011601	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1192196011602	RNA polymerase factor sigma-70; Validated; Region: PRK08295
1192196011603	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1192196011604	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1192196011605	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
1192196011606	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1192196011607	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1192196011608	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1192196011609	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1192196011610	active site
1192196011611	metal binding site [ion binding]; metal-binding site
1192196011612	dimerization interface [polypeptide binding]; other site
1192196011613	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1192196011614	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1192196011615	active site
1192196011616	HIGH motif; other site
1192196011617	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1192196011618	KMSKS motif; other site
1192196011619	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1192196011620	tRNA binding surface [nucleotide binding]; other site
1192196011621	anticodon binding site; other site
1192196011622	serine O-acetyltransferase; Region: cysE; TIGR01172
1192196011623	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1192196011624	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1192196011625	trimer interface [polypeptide binding]; other site
1192196011626	active site
1192196011627	substrate binding site [chemical binding]; other site
1192196011628	CoA binding site [chemical binding]; other site
1192196011629	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1192196011630	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1192196011631	active site
1192196011632	HIGH motif; other site
1192196011633	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1192196011634	active site
1192196011635	KMSKS motif; other site
1192196011636	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1192196011637	homotrimer interaction site [polypeptide binding]; other site
1192196011638	zinc binding site [ion binding]; other site
1192196011639	CDP-binding sites; other site
1192196011640	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1192196011641	substrate binding site; other site
1192196011642	dimer interface; other site
1192196011643	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1192196011644	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1192196011645	putative active site [active]
1192196011646	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
1192196011647	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1192196011648	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
1192196011649	DNA repair protein RadA; Provisional; Region: PRK11823
1192196011650	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1192196011651	Walker A motif/ATP binding site; other site
1192196011652	ATP binding site [chemical binding]; other site
1192196011653	Walker B motif; other site
1192196011654	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1192196011655	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1192196011656	Clp amino terminal domain; Region: Clp_N; pfam02861
1192196011657	Clp amino terminal domain; Region: Clp_N; pfam02861
1192196011658	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196011659	Walker A motif; other site
1192196011660	ATP binding site [chemical binding]; other site
1192196011661	Walker B motif; other site
1192196011662	arginine finger; other site
1192196011663	UvrB/uvrC motif; Region: UVR; pfam02151
1192196011664	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196011665	Walker A motif; other site
1192196011666	ATP binding site [chemical binding]; other site
1192196011667	Walker B motif; other site
1192196011668	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1192196011669	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
1192196011670	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1192196011671	ADP binding site [chemical binding]; other site
1192196011672	phosphagen binding site; other site
1192196011673	substrate specificity loop; other site
1192196011674	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
1192196011675	UvrB/uvrC motif; Region: UVR; pfam02151
1192196011676	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
1192196011677	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1192196011678	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1192196011679	dimer interface [polypeptide binding]; other site
1192196011680	putative anticodon binding site; other site
1192196011681	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1192196011682	motif 1; other site
1192196011683	active site
1192196011684	motif 2; other site
1192196011685	motif 3; other site
1192196011686	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1192196011687	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1192196011688	FMN binding site [chemical binding]; other site
1192196011689	active site
1192196011690	catalytic residues [active]
1192196011691	substrate binding site [chemical binding]; other site
1192196011692	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1192196011693	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1192196011694	sequence-specific DNA binding site [nucleotide binding]; other site
1192196011695	salt bridge; other site
1192196011696	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1192196011697	catalytic center binding site [active]
1192196011698	ATP binding site [chemical binding]; other site
1192196011699	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1192196011700	homooctamer interface [polypeptide binding]; other site
1192196011701	active site
1192196011702	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1192196011703	dihydropteroate synthase; Region: DHPS; TIGR01496
1192196011704	substrate binding pocket [chemical binding]; other site
1192196011705	dimer interface [polypeptide binding]; other site
1192196011706	inhibitor binding site; inhibition site
1192196011707	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1192196011708	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1192196011709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196011710	catalytic residue [active]
1192196011711	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1192196011712	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1192196011713	glutamine binding [chemical binding]; other site
1192196011714	catalytic triad [active]
1192196011715	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1192196011716	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1192196011717	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1192196011718	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1192196011719	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1192196011720	dimer interface [polypeptide binding]; other site
1192196011721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1192196011722	catalytic residue [active]
1192196011723	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1192196011724	SurA N-terminal domain; Region: SurA_N_3; cl07813
1192196011725	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1192196011726	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1192196011727	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1192196011728	dimerization interface [polypeptide binding]; other site
1192196011729	domain crossover interface; other site
1192196011730	redox-dependent activation switch; other site
1192196011731	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1192196011732	nucleotide binding site [chemical binding]; other site
1192196011733	FtsH Extracellular; Region: FtsH_ext; pfam06480
1192196011734	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1192196011735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196011736	Walker A motif; other site
1192196011737	ATP binding site [chemical binding]; other site
1192196011738	Walker B motif; other site
1192196011739	arginine finger; other site
1192196011740	Peptidase family M41; Region: Peptidase_M41; pfam01434
1192196011741	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1192196011742	active site
1192196011743	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1192196011744	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1192196011745	Ligand Binding Site [chemical binding]; other site
1192196011746	TilS substrate binding domain; Region: TilS; pfam09179
1192196011747	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1192196011748	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1192196011749	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1192196011750	active site
1192196011751	ATP binding site [chemical binding]; other site
1192196011752	substrate binding site [chemical binding]; other site
1192196011753	activation loop (A-loop); other site
1192196011754	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1192196011755	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1192196011756	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1192196011757	metal ion-dependent adhesion site (MIDAS); other site
1192196011758	stage II sporulation protein E; Region: spore_II_E; TIGR02865
1192196011759	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1192196011760	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1192196011761	hypothetical protein; Provisional; Region: PRK08582
1192196011762	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1192196011763	RNA binding site [nucleotide binding]; other site
1192196011764	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1192196011765	Septum formation initiator; Region: DivIC; pfam04977
1192196011766	spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893
1192196011767	sporulation protein YabP; Region: spore_yabP; TIGR02892
1192196011768	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1192196011769	RNA binding surface [nucleotide binding]; other site
1192196011770	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
1192196011771	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
1192196011772	putative SAM binding site [chemical binding]; other site
1192196011773	putative homodimer interface [polypeptide binding]; other site
1192196011774	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1192196011775	homodimer interface [polypeptide binding]; other site
1192196011776	metal binding site [ion binding]; metal-binding site
1192196011777	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1192196011778	homodimer interface [polypeptide binding]; other site
1192196011779	active site
1192196011780	putative chemical substrate binding site [chemical binding]; other site
1192196011781	metal binding site [ion binding]; metal-binding site
1192196011782	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1192196011783	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1192196011784	stage V sporulation protein T; Region: spore_V_T; TIGR02851
1192196011785	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
1192196011786	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1192196011787	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1192196011788	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1192196011789	ATP binding site [chemical binding]; other site
1192196011790	putative Mg++ binding site [ion binding]; other site
1192196011791	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1192196011792	nucleotide binding region [chemical binding]; other site
1192196011793	ATP-binding site [chemical binding]; other site
1192196011794	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1192196011795	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
1192196011796	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1192196011797	putative active site [active]
1192196011798	catalytic residue [active]
1192196011799	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1192196011800	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
1192196011801	5S rRNA interface [nucleotide binding]; other site
1192196011802	CTC domain interface [polypeptide binding]; other site
1192196011803	L16 interface [polypeptide binding]; other site
1192196011804	RNA island Y
1192196011805	regulatory protein SpoVG; Reviewed; Region: PRK13259
1192196011806	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1192196011807	homotrimer interaction site [polypeptide binding]; other site
1192196011808	putative active site [active]
1192196011809	pur operon repressor; Provisional; Region: PRK09213
1192196011810	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1192196011811	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1192196011812	active site
1192196011813	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1192196011814	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1192196011815	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1192196011816	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1192196011817	sporulation peptidase YabG; Region: spore_yabG; TIGR02855
1192196011818	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1192196011819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196011820	S-adenosylmethionine binding site [chemical binding]; other site
1192196011821	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1192196011822	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1192196011823	putative active site [active]
1192196011824	putative metal binding site [ion binding]; other site
1192196011825	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1192196011826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
1192196011827	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1192196011828	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1192196011829	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1192196011830	G5 domain; Region: G5; pfam07501
1192196011831	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1192196011832	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1192196011833	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1192196011834	active site
1192196011835	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1192196011836	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1192196011837	active site
1192196011838	HIGH motif; other site
1192196011839	KMSKS motif; other site
1192196011840	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1192196011841	tRNA binding surface [nucleotide binding]; other site
1192196011842	anticodon binding site; other site
1192196011843	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1192196011844	dimer interface [polypeptide binding]; other site
1192196011845	putative tRNA-binding site [nucleotide binding]; other site
1192196011846	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1192196011847	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1192196011848	Predicted methyltransferases [General function prediction only]; Region: COG0313
1192196011849	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1192196011850	putative SAM binding site [chemical binding]; other site
1192196011851	putative homodimer interface [polypeptide binding]; other site
1192196011852	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1192196011853	GIY-YIG motif/motif A; other site
1192196011854	putative active site [active]
1192196011855	putative metal binding site [ion binding]; other site
1192196011856	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1192196011857	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1192196011858	S-adenosylmethionine binding site [chemical binding]; other site
1192196011859	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
1192196011860	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1192196011861	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1192196011862	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1192196011863	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728
1192196011864	Protein of unknown function (DUF970); Region: DUF970; pfam06153
1192196011865	thymidylate kinase; Validated; Region: tmk; PRK00698
1192196011866	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1192196011867	TMP-binding site; other site
1192196011868	ATP-binding site [chemical binding]; other site
1192196011869	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1192196011870	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1192196011871	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1192196011872	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1192196011873	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
1192196011874	pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862
1192196011875	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
1192196011876	recombination protein RecR; Reviewed; Region: recR; PRK00076
1192196011877	RecR protein; Region: RecR; pfam02132
1192196011878	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1192196011879	putative active site [active]
1192196011880	putative metal-binding site [ion binding]; other site
1192196011881	tetramer interface [polypeptide binding]; other site
1192196011882	hypothetical protein; Validated; Region: PRK00153
1192196011883	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1192196011884	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196011885	Walker A motif; other site
1192196011886	ATP binding site [chemical binding]; other site
1192196011887	Walker B motif; other site
1192196011888	arginine finger; other site
1192196011889	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1192196011890	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1192196011891	nucleoside/Zn binding site; other site
1192196011892	dimer interface [polypeptide binding]; other site
1192196011893	catalytic motif [active]
1192196011894	Isochorismatase family; Region: Isochorismatase; pfam00857
1192196011895	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1192196011896	catalytic triad [active]
1192196011897	conserved cis-peptide bond; other site
1192196011898	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1192196011899	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196011900	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1192196011901	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1192196011902	active site
1192196011903	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1192196011904	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1192196011905	Substrate-binding site [chemical binding]; other site
1192196011906	Substrate specificity [chemical binding]; other site
1192196011907	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1192196011908	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1192196011909	Substrate-binding site [chemical binding]; other site
1192196011910	Substrate specificity [chemical binding]; other site
1192196011911	seryl-tRNA synthetase; Provisional; Region: PRK05431
1192196011912	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1192196011913	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1192196011914	dimer interface [polypeptide binding]; other site
1192196011915	active site
1192196011916	motif 1; other site
1192196011917	motif 2; other site
1192196011918	motif 3; other site
1192196011919	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1192196011920	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1192196011921	predicted active site [active]
1192196011922	catalytic triad [active]
1192196011923	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1192196011924	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1192196011925	active site
1192196011926	multimer interface [polypeptide binding]; other site
1192196011927	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1192196011928	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1192196011929	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1192196011930	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1192196011931	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1192196011932	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1192196011933	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1192196011934	active site
1192196011935	YaaC-like Protein; Region: YaaC; pfam14175
1192196011936	DNA gyrase subunit A; Validated; Region: PRK05560
1192196011937	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1192196011938	CAP-like domain; other site
1192196011939	active site
1192196011940	primary dimer interface [polypeptide binding]; other site
1192196011941	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1192196011942	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1192196011943	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1192196011944	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1192196011945	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1192196011946	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1192196011947	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1192196011948	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1192196011949	ATP binding site [chemical binding]; other site
1192196011950	Mg2+ binding site [ion binding]; other site
1192196011951	G-X-G motif; other site
1192196011952	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1192196011953	anchoring element; other site
1192196011954	dimer interface [polypeptide binding]; other site
1192196011955	ATP binding site [chemical binding]; other site
1192196011956	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1192196011957	active site
1192196011958	putative metal-binding site [ion binding]; other site
1192196011959	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1192196011960	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
1192196011961	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1192196011962	Walker A/P-loop; other site
1192196011963	ATP binding site [chemical binding]; other site
1192196011964	Q-loop/lid; other site
1192196011965	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1192196011966	ABC transporter signature motif; other site
1192196011967	Walker B; other site
1192196011968	D-loop; other site
1192196011969	H-loop/switch region; other site
1192196011970	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
1192196011971	DNA polymerase III subunit beta; Validated; Region: PRK05643
1192196011972	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1192196011973	putative DNA binding surface [nucleotide binding]; other site
1192196011974	dimer interface [polypeptide binding]; other site
1192196011975	beta-clamp/clamp loader binding surface; other site
1192196011976	beta-clamp/translesion DNA polymerase binding surface; other site
1192196011977	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1192196011978	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1192196011979	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1192196011980	Walker A motif; other site
1192196011981	ATP binding site [chemical binding]; other site
1192196011982	Walker B motif; other site
1192196011983	arginine finger; other site
1192196011984	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1192196011985	DnaA box-binding interface [nucleotide binding]; other site