-- dump date 20140618_223703 -- class Genbank::misc_feature -- table misc_feature_note -- id note 936156000001 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 936156000002 Methyltransferase domain; Region: Methyltransf_23; pfam13489 936156000003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156000004 S-adenosylmethionine binding site [chemical binding]; other site 936156000005 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 936156000006 putative metal binding site; other site 936156000007 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156000008 binding surface 936156000009 TPR motif; other site 936156000010 TPR repeat; Region: TPR_11; pfam13414 936156000011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156000012 binding surface 936156000013 TPR motif; other site 936156000014 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 936156000015 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 936156000016 Probable Catalytic site; other site 936156000017 metal-binding site 936156000018 Methyltransferase domain; Region: Methyltransf_23; pfam13489 936156000019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156000020 S-adenosylmethionine binding site [chemical binding]; other site 936156000021 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 936156000022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156000023 Coenzyme A binding pocket [chemical binding]; other site 936156000024 CAAX protease self-immunity; Region: Abi; cl00558 936156000025 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 936156000026 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 936156000027 Predicted acetyltransferase [General function prediction only]; Region: COG3153 936156000028 Coenzyme A binding pocket [chemical binding]; other site 936156000029 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 936156000030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156000031 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 936156000032 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 936156000033 inhibitor binding site; inhibition site 936156000034 active site 936156000035 Transcriptional regulators [Transcription]; Region: MarR; COG1846 936156000036 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 936156000037 non-specific DNA interactions [nucleotide binding]; other site 936156000038 DNA binding site [nucleotide binding] 936156000039 sequence specific DNA binding site [nucleotide binding]; other site 936156000040 putative cAMP binding site [chemical binding]; other site 936156000041 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 936156000042 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936156000043 nucleotide binding site [chemical binding]; other site 936156000044 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 936156000045 xylose isomerase; Provisional; Region: PRK05474 936156000046 xylose isomerase; Region: xylose_isom_A; TIGR02630 936156000047 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 936156000048 N- and C-terminal domain interface [polypeptide binding]; other site 936156000049 D-xylulose kinase; Region: XylB; TIGR01312 936156000050 active site 936156000051 MgATP binding site [chemical binding]; other site 936156000052 catalytic site [active] 936156000053 metal binding site [ion binding]; metal-binding site 936156000054 xylulose binding site [chemical binding]; other site 936156000055 homodimer interface [polypeptide binding]; other site 936156000056 Staphylococcal nuclease homologues; Region: SNc; smart00318 936156000057 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 936156000058 Catalytic site; other site 936156000059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156000060 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 936156000061 putative substrate translocation pore; other site 936156000062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156000063 alanine racemase; Region: alr; TIGR00492 936156000064 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 936156000065 active site 936156000066 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936156000067 dimer interface [polypeptide binding]; other site 936156000068 substrate binding site [chemical binding]; other site 936156000069 catalytic residues [active] 936156000070 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 936156000071 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 936156000072 trimer interface [polypeptide binding]; other site 936156000073 active site 936156000074 thymidylate synthase; Reviewed; Region: thyA; PRK01827 936156000075 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 936156000076 dimerization interface [polypeptide binding]; other site 936156000077 active site 936156000078 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 936156000079 putative binding site; other site 936156000080 putative dimer interface [polypeptide binding]; other site 936156000081 YoqO-like protein; Region: YoqO; pfam14037 936156000082 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 936156000083 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 936156000084 putative hydrophobic ligand binding site [chemical binding]; other site 936156000085 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 936156000086 Spore germination protein; Region: Spore_permease; pfam03845 936156000087 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 936156000088 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 936156000089 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 936156000090 YndJ-like protein; Region: YndJ; pfam14158 936156000091 Phage-related replication protein [General function prediction only]; Region: COG4195 936156000092 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 936156000093 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 936156000094 active site 936156000095 LexA repressor; Validated; Region: PRK00215 936156000096 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156000097 putative DNA binding site [nucleotide binding]; other site 936156000098 putative Zn2+ binding site [ion binding]; other site 936156000099 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 936156000100 Catalytic site [active] 936156000101 cell division suppressor protein YneA; Provisional; Region: PRK14125 936156000102 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156000103 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 936156000104 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 936156000105 catalytic residues [active] 936156000106 catalytic nucleophile [active] 936156000107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 936156000108 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 936156000109 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 936156000110 TPP-binding site [chemical binding]; other site 936156000111 dimer interface [polypeptide binding]; other site 936156000112 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 936156000113 PYR/PP interface [polypeptide binding]; other site 936156000114 dimer interface [polypeptide binding]; other site 936156000115 TPP binding site [chemical binding]; other site 936156000116 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 936156000117 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 936156000118 hypothetical protein; Provisional; Region: PRK01844 936156000119 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 936156000120 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 936156000121 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 936156000122 Response regulator receiver domain; Region: Response_reg; pfam00072 936156000123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156000124 active site 936156000125 phosphorylation site [posttranslational modification] 936156000126 intermolecular recognition site; other site 936156000127 dimerization interface [polypeptide binding]; other site 936156000128 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 936156000129 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 936156000130 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 936156000131 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 936156000132 putative dimer interface [polypeptide binding]; other site 936156000133 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 936156000134 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 936156000135 aconitate hydratase; Validated; Region: PRK09277 936156000136 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 936156000137 substrate binding site [chemical binding]; other site 936156000138 ligand binding site [chemical binding]; other site 936156000139 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 936156000140 substrate binding site [chemical binding]; other site 936156000141 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 936156000142 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 936156000143 catalytic residues [active] 936156000144 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 936156000145 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 936156000146 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 936156000147 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 936156000148 active site 936156000149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 936156000150 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 936156000151 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 936156000152 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 936156000153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156000154 ATP binding site [chemical binding]; other site 936156000155 Mg2+ binding site [ion binding]; other site 936156000156 G-X-G motif; other site 936156000157 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 936156000158 anchoring element; other site 936156000159 dimer interface [polypeptide binding]; other site 936156000160 ATP binding site [chemical binding]; other site 936156000161 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 936156000162 active site 936156000163 putative metal-binding site [ion binding]; other site 936156000164 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 936156000165 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 936156000166 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 936156000167 CAP-like domain; other site 936156000168 active site 936156000169 primary dimer interface [polypeptide binding]; other site 936156000170 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936156000171 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936156000172 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936156000173 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936156000174 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 936156000175 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 936156000176 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 936156000177 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 936156000178 Cellulose binding domain; Region: CBM_3; pfam00942 936156000179 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 936156000180 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 936156000181 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 936156000182 substrate binding site [chemical binding]; other site 936156000183 active site 936156000184 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 936156000185 metal binding site [ion binding]; metal-binding site 936156000186 ligand binding site [chemical binding]; other site 936156000187 Predicted membrane protein [Function unknown]; Region: COG2246 936156000188 GtrA-like protein; Region: GtrA; pfam04138 936156000189 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 936156000190 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 936156000191 active site 936156000192 tetramer interface; other site 936156000193 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 936156000194 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 936156000195 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 936156000196 DHH family; Region: DHH; pfam01368 936156000197 DHHA1 domain; Region: DHHA1; pfam02272 936156000198 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 936156000199 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 936156000200 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 936156000201 enoyl-CoA hydratase; Provisional; Region: PRK07657 936156000202 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 936156000203 substrate binding site [chemical binding]; other site 936156000204 oxyanion hole (OAH) forming residues; other site 936156000205 trimer interface [polypeptide binding]; other site 936156000206 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 936156000207 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 936156000208 active site 936156000209 catalytic residues [active] 936156000210 metal binding site [ion binding]; metal-binding site 936156000211 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 936156000212 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 936156000213 carboxyltransferase (CT) interaction site; other site 936156000214 biotinylation site [posttranslational modification]; other site 936156000215 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 936156000216 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936156000217 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 936156000218 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 936156000219 AMP-binding domain protein; Validated; Region: PRK08315 936156000220 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 936156000221 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 936156000222 acyl-activating enzyme (AAE) consensus motif; other site 936156000223 putative AMP binding site [chemical binding]; other site 936156000224 putative active site [active] 936156000225 putative CoA binding site [chemical binding]; other site 936156000226 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 936156000227 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 936156000228 active site 936156000229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 936156000230 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 936156000231 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 936156000232 Condensation domain; Region: Condensation; pfam00668 936156000233 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156000234 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 936156000235 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 936156000236 acyl-activating enzyme (AAE) consensus motif; other site 936156000237 AMP binding site [chemical binding]; other site 936156000238 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156000239 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 936156000240 Condensation domain; Region: Condensation; pfam00668 936156000241 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156000242 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936156000243 acyl-activating enzyme (AAE) consensus motif; other site 936156000244 AMP binding site [chemical binding]; other site 936156000245 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156000246 Condensation domain; Region: Condensation; pfam00668 936156000247 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156000248 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 936156000249 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936156000250 acyl-activating enzyme (AAE) consensus motif; other site 936156000251 AMP binding site [chemical binding]; other site 936156000252 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156000253 Condensation domain; Region: Condensation; pfam00668 936156000254 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156000255 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 936156000256 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936156000257 acyl-activating enzyme (AAE) consensus motif; other site 936156000258 AMP binding site [chemical binding]; other site 936156000259 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156000260 Condensation domain; Region: Condensation; pfam00668 936156000261 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 936156000262 Condensation domain; Region: Condensation; pfam00668 936156000263 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156000264 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936156000265 acyl-activating enzyme (AAE) consensus motif; other site 936156000266 AMP binding site [chemical binding]; other site 936156000267 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156000268 Condensation domain; Region: Condensation; pfam00668 936156000269 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156000270 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 936156000271 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 936156000272 acyl-activating enzyme (AAE) consensus motif; other site 936156000273 AMP binding site [chemical binding]; other site 936156000274 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156000275 Condensation domain; Region: Condensation; pfam00668 936156000276 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 936156000277 Condensation domain; Region: Condensation; pfam00668 936156000278 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156000279 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936156000280 acyl-activating enzyme (AAE) consensus motif; other site 936156000281 AMP binding site [chemical binding]; other site 936156000282 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156000283 Condensation domain; Region: Condensation; pfam00668 936156000284 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156000285 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 936156000286 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936156000287 acyl-activating enzyme (AAE) consensus motif; other site 936156000288 AMP binding site [chemical binding]; other site 936156000289 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156000290 Condensation domain; Region: Condensation; pfam00668 936156000291 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156000292 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 936156000293 potential frameshift: common BLAST hit: gi|255767429|ref|NP_389716.2| plipastatin synthetase 936156000294 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 936156000295 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 936156000296 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 936156000297 active site 936156000298 catalytic residues [active] 936156000299 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 936156000300 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 936156000301 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 936156000302 Int/Topo IB signature motif; other site 936156000303 Helix-turn-helix domain; Region: HTH_17; cl17695 936156000304 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 936156000305 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 936156000306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156000307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156000308 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 936156000309 putative dimerization interface [polypeptide binding]; other site 936156000310 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 936156000311 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 936156000312 NAD(P) binding site [chemical binding]; other site 936156000313 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 936156000314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936156000315 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 936156000316 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 936156000317 active site 936156000318 dimer interface [polypeptide binding]; other site 936156000319 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 936156000320 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 936156000321 active site 936156000322 FMN binding site [chemical binding]; other site 936156000323 substrate binding site [chemical binding]; other site 936156000324 3Fe-4S cluster binding site [ion binding]; other site 936156000325 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 936156000326 domain interface; other site 936156000327 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156000328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156000329 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 936156000330 putative dimerization interface [polypeptide binding]; other site 936156000331 gamma-glutamyl kinase; Provisional; Region: PRK13402 936156000332 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 936156000333 nucleotide binding site [chemical binding]; other site 936156000334 homotetrameric interface [polypeptide binding]; other site 936156000335 putative phosphate binding site [ion binding]; other site 936156000336 putative allosteric binding site; other site 936156000337 PUA domain; Region: PUA; pfam01472 936156000338 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 936156000339 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 936156000340 Replication terminator protein; Region: RTP; pfam02334 936156000341 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 936156000342 classical (c) SDRs; Region: SDR_c; cd05233 936156000343 NAD(P) binding site [chemical binding]; other site 936156000344 active site 936156000345 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 936156000346 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 936156000347 polyol permease family; Region: 2A0118; TIGR00897 936156000348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156000349 putative substrate translocation pore; other site 936156000350 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 936156000351 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 936156000352 putative N- and C-terminal domain interface [polypeptide binding]; other site 936156000353 putative active site [active] 936156000354 putative MgATP binding site [chemical binding]; other site 936156000355 catalytic site [active] 936156000356 metal binding site [ion binding]; metal-binding site 936156000357 carbohydrate binding site [chemical binding]; other site 936156000358 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 936156000359 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 936156000360 putative ligand binding site [chemical binding]; other site 936156000361 putative NAD binding site [chemical binding]; other site 936156000362 catalytic site [active] 936156000363 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 936156000364 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 936156000365 putative [4Fe-4S] binding site [ion binding]; other site 936156000366 putative molybdopterin cofactor binding site [chemical binding]; other site 936156000367 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 936156000368 putative molybdopterin cofactor binding site; other site 936156000369 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 936156000370 CHASE3 domain; Region: CHASE3; cl05000 936156000371 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936156000372 dimerization interface [polypeptide binding]; other site 936156000373 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936156000374 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936156000375 dimer interface [polypeptide binding]; other site 936156000376 putative CheW interface [polypeptide binding]; other site 936156000377 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 936156000378 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 936156000379 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 936156000380 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 936156000381 Predicted membrane protein [Function unknown]; Region: COG3619 936156000382 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 936156000383 Amb_all domain; Region: Amb_all; smart00656 936156000384 Uncharacterized conserved protein [Function unknown]; Region: COG2135 936156000385 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 936156000386 Cupin; Region: Cupin_1; smart00835 936156000387 Cupin; Region: Cupin_1; smart00835 936156000388 YoaP-like; Region: YoaP; pfam14268 936156000389 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 936156000390 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 936156000391 VanW like protein; Region: VanW; pfam04294 936156000392 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 936156000393 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156000394 salt bridge; other site 936156000395 non-specific DNA binding site [nucleotide binding]; other site 936156000396 sequence-specific DNA binding site [nucleotide binding]; other site 936156000397 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 936156000398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156000399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156000400 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936156000401 dimerization interface [polypeptide binding]; other site 936156000402 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 936156000403 EamA-like transporter family; Region: EamA; pfam00892 936156000404 EamA-like transporter family; Region: EamA; pfam00892 936156000405 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 936156000406 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 936156000407 conserved cys residue [active] 936156000408 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 936156000409 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 936156000410 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 936156000411 phosphoenolpyruvate synthase; Validated; Region: PRK06241 936156000412 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 936156000413 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 936156000414 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 936156000415 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 936156000416 Uncharacterized conserved protein [Function unknown]; Region: COG5444 936156000417 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 936156000418 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 936156000419 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 936156000420 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 936156000421 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 936156000422 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 936156000423 dimer interface [polypeptide binding]; other site 936156000424 putative tRNA-binding site [nucleotide binding]; other site 936156000425 Cupin domain; Region: Cupin_2; pfam07883 936156000426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156000427 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936156000428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156000429 Coenzyme A binding pocket [chemical binding]; other site 936156000430 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156000431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156000432 WHG domain; Region: WHG; pfam13305 936156000433 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 936156000434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 936156000435 Predicted transcriptional regulator [Transcription]; Region: COG2378 936156000436 HTH domain; Region: HTH_11; pfam08279 936156000437 WYL domain; Region: WYL; pfam13280 936156000438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156000439 dimerization interface [polypeptide binding]; other site 936156000440 putative DNA binding site [nucleotide binding]; other site 936156000441 putative Zn2+ binding site [ion binding]; other site 936156000442 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 936156000443 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 936156000444 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936156000445 catalytic residue [active] 936156000446 Predicted membrane protein [Function unknown]; Region: COG2322 936156000447 Protein required for attachment to host cells; Region: Host_attach; cl02398 936156000448 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 936156000449 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 936156000450 putative dimer interface [polypeptide binding]; other site 936156000451 catalytic triad [active] 936156000452 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 936156000453 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 936156000454 putative di-iron ligands [ion binding]; other site 936156000455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 936156000456 Histidine kinase; Region: HisKA_3; pfam07730 936156000457 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 936156000458 ATP binding site [chemical binding]; other site 936156000459 Mg2+ binding site [ion binding]; other site 936156000460 G-X-G motif; other site 936156000461 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936156000462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156000463 active site 936156000464 phosphorylation site [posttranslational modification] 936156000465 intermolecular recognition site; other site 936156000466 dimerization interface [polypeptide binding]; other site 936156000467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936156000468 DNA binding residues [nucleotide binding] 936156000469 dimerization interface [polypeptide binding]; other site 936156000470 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156000471 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156000472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 936156000473 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 936156000474 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936156000475 ATP binding site [chemical binding]; other site 936156000476 putative Mg++ binding site [ion binding]; other site 936156000477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156000478 nucleotide binding region [chemical binding]; other site 936156000479 ATP-binding site [chemical binding]; other site 936156000480 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 936156000481 Helicase and RNase D C-terminal; Region: HRDC; smart00341 936156000482 azoreductase; Provisional; Region: PRK13556 936156000483 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 936156000484 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 936156000485 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 936156000486 putative dimer interface [polypeptide binding]; other site 936156000487 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 936156000488 pentamer interface [polypeptide binding]; other site 936156000489 dodecaamer interface [polypeptide binding]; other site 936156000490 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 936156000491 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 936156000492 NAD(P) binding site [chemical binding]; other site 936156000493 catalytic residues [active] 936156000494 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 936156000495 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 936156000496 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 936156000497 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 936156000498 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 936156000499 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 936156000500 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 936156000501 Na2 binding site [ion binding]; other site 936156000502 putative substrate binding site 1 [chemical binding]; other site 936156000503 Na binding site 1 [ion binding]; other site 936156000504 putative substrate binding site 2 [chemical binding]; other site 936156000505 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 936156000506 Sodium Bile acid symporter family; Region: SBF; pfam01758 936156000507 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 936156000508 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 936156000509 E3 interaction surface; other site 936156000510 lipoyl attachment site [posttranslational modification]; other site 936156000511 e3 binding domain; Region: E3_binding; pfam02817 936156000512 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 936156000513 2-oxoglutarate dehydrogenase, E1 component; Region: 2oxo_dh_E1; TIGR00239 936156000514 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 936156000515 TPP-binding site [chemical binding]; other site 936156000516 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 936156000517 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 936156000518 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 936156000519 metal ion-dependent adhesion site (MIDAS); other site 936156000520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156000521 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 936156000522 Walker A motif; other site 936156000523 ATP binding site [chemical binding]; other site 936156000524 Walker B motif; other site 936156000525 arginine finger; other site 936156000526 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 936156000527 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 936156000528 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 936156000529 E-class dimer interface [polypeptide binding]; other site 936156000530 P-class dimer interface [polypeptide binding]; other site 936156000531 active site 936156000532 Cu2+ binding site [ion binding]; other site 936156000533 Zn2+ binding site [ion binding]; other site 936156000534 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156000535 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156000536 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156000537 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156000538 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 936156000539 NlpC/P60 family; Region: NLPC_P60; pfam00877 936156000540 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 936156000541 glycosyltransferase, MGT family; Region: MGT; TIGR01426 936156000542 active site 936156000543 TDP-binding site; other site 936156000544 acceptor substrate-binding pocket; other site 936156000545 Uncharacterized conserved protein [Function unknown]; Region: COG1624 936156000546 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 936156000547 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 936156000548 multidrug efflux protein; Reviewed; Region: PRK01766 936156000549 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 936156000550 cation binding site [ion binding]; other site 936156000551 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 936156000552 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 936156000553 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 936156000554 rarD protein; Region: rarD; TIGR00688 936156000555 EamA-like transporter family; Region: EamA; pfam00892 936156000556 GntP family permease; Region: GntP_permease; pfam02447 936156000557 fructuronate transporter; Provisional; Region: PRK10034; cl15264 936156000558 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 936156000559 Predicted transcriptional regulators [Transcription]; Region: COG1733 936156000560 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156000561 dimerization interface [polypeptide binding]; other site 936156000562 putative DNA binding site [nucleotide binding]; other site 936156000563 putative Zn2+ binding site [ion binding]; other site 936156000564 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 936156000565 dimer interface [polypeptide binding]; other site 936156000566 FMN binding site [chemical binding]; other site 936156000567 Predicted esterase [General function prediction only]; Region: COG0400 936156000568 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 936156000569 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156000570 Zn binding site [ion binding]; other site 936156000571 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 936156000572 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156000573 Zn binding site [ion binding]; other site 936156000574 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 936156000575 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 936156000576 Na binding site [ion binding]; other site 936156000577 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 936156000578 C-terminal peptidase (prc); Region: prc; TIGR00225 936156000579 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 936156000580 protein binding site [polypeptide binding]; other site 936156000581 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 936156000582 Catalytic dyad [active] 936156000583 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 936156000584 Methyltransferase domain; Region: Methyltransf_31; pfam13847 936156000585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156000586 S-adenosylmethionine binding site [chemical binding]; other site 936156000587 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 936156000588 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 936156000589 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 936156000590 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 936156000591 YodL-like; Region: YodL; pfam14191 936156000592 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 936156000593 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 936156000594 active site 936156000595 YozD-like protein; Region: YozD; pfam14162 936156000596 hypothetical protein; Provisional; Region: PRK13672 936156000597 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 936156000598 toxin interface [polypeptide binding]; other site 936156000599 Zn binding site [ion binding]; other site 936156000600 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 936156000601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936156000602 FeS/SAM binding site; other site 936156000603 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 936156000604 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 936156000605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156000606 Coenzyme A binding pocket [chemical binding]; other site 936156000607 acetylornithine deacetylase; Validated; Region: PRK06915 936156000608 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 936156000609 metal binding site [ion binding]; metal-binding site 936156000610 dimer interface [polypeptide binding]; other site 936156000611 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 936156000612 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 936156000613 hypothetical protein; Provisional; Region: PRK06917 936156000614 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936156000615 inhibitor-cofactor binding pocket; inhibition site 936156000616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156000617 catalytic residue [active] 936156000618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156000619 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 936156000620 Coenzyme A binding pocket [chemical binding]; other site 936156000621 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 936156000622 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 936156000623 active site 936156000624 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 936156000625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 936156000626 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 936156000627 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 936156000628 Phytase; Region: Phytase; cl17685 936156000629 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 936156000630 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 936156000631 NAD(P) binding site [chemical binding]; other site 936156000632 homodimer interface [polypeptide binding]; other site 936156000633 substrate binding site [chemical binding]; other site 936156000634 active site 936156000635 methionine sulfoxide reductase B; Provisional; Region: PRK00222 936156000636 SelR domain; Region: SelR; pfam01641 936156000637 methionine sulfoxide reductase A; Provisional; Region: PRK14054 936156000638 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156000639 MarR family; Region: MarR; pfam01047 936156000640 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 936156000641 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 936156000642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 936156000643 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 936156000644 active site 936156000645 catalytic triad [active] 936156000646 oxyanion hole [active] 936156000647 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 936156000648 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 936156000649 Cu(I) binding site [ion binding]; other site 936156000650 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 936156000651 threonine dehydratase; Validated; Region: PRK08639 936156000652 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 936156000653 tetramer interface [polypeptide binding]; other site 936156000654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156000655 catalytic residue [active] 936156000656 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 936156000657 putative Ile/Val binding site [chemical binding]; other site 936156000658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156000659 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 936156000660 Walker A motif; other site 936156000661 ATP binding site [chemical binding]; other site 936156000662 Walker B motif; other site 936156000663 arginine finger; other site 936156000664 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 936156000665 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 936156000666 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 936156000667 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 936156000668 putative acyl-acceptor binding pocket; other site 936156000669 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 936156000670 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 936156000671 folate binding site [chemical binding]; other site 936156000672 NADP+ binding site [chemical binding]; other site 936156000673 thymidylate synthase; Reviewed; Region: thyA; PRK01827 936156000674 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 936156000675 dimerization interface [polypeptide binding]; other site 936156000676 active site 936156000677 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 936156000678 tetramer interfaces [polypeptide binding]; other site 936156000679 binuclear metal-binding site [ion binding]; other site 936156000680 YpjP-like protein; Region: YpjP; pfam14005 936156000681 ribosomal biogenesis protein; Validated; Region: PRK00933 936156000682 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 936156000683 Disulphide isomerase; Region: Disulph_isomer; pfam06491 936156000684 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 936156000685 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 936156000686 Virulence factor; Region: Virulence_fact; pfam13769 936156000687 HEAT repeats; Region: HEAT_2; pfam13646 936156000688 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 936156000689 HEAT repeats; Region: HEAT_2; pfam13646 936156000690 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 936156000691 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 936156000692 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936156000693 Zn2+ binding site [ion binding]; other site 936156000694 Mg2+ binding site [ion binding]; other site 936156000695 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 936156000696 catalytic residues [active] 936156000697 dimer interface [polypeptide binding]; other site 936156000698 homoserine O-succinyltransferase; Provisional; Region: PRK05368 936156000699 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 936156000700 proposed active site lysine [active] 936156000701 conserved cys residue [active] 936156000702 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 936156000703 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 936156000704 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 936156000705 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 936156000706 DNA-binding site [nucleotide binding]; DNA binding site 936156000707 RNA-binding motif; other site 936156000708 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 936156000709 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 936156000710 hypothetical protein; Validated; Region: PRK07708 936156000711 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 936156000712 RNA/DNA hybrid binding site [nucleotide binding]; other site 936156000713 active site 936156000714 conserved hypothetical integral membrane protein; Region: TIGR00697 936156000715 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 936156000716 RNA/DNA hybrid binding site [nucleotide binding]; other site 936156000717 active site 936156000718 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 936156000719 5'-3' exonuclease; Region: 53EXOc; smart00475 936156000720 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 936156000721 active site 936156000722 metal binding site 1 [ion binding]; metal-binding site 936156000723 putative 5' ssDNA interaction site; other site 936156000724 metal binding site 3; metal-binding site 936156000725 metal binding site 2 [ion binding]; metal-binding site 936156000726 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 936156000727 putative DNA binding site [nucleotide binding]; other site 936156000728 putative metal binding site [ion binding]; other site 936156000729 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 936156000730 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 936156000731 Dynamin family; Region: Dynamin_N; pfam00350 936156000732 G1 box; other site 936156000733 GTP/Mg2+ binding site [chemical binding]; other site 936156000734 G2 box; other site 936156000735 Switch I region; other site 936156000736 G3 box; other site 936156000737 Switch II region; other site 936156000738 G4 box; other site 936156000739 G5 box; other site 936156000740 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 936156000741 G1 box; other site 936156000742 GTP/Mg2+ binding site [chemical binding]; other site 936156000743 Dynamin family; Region: Dynamin_N; pfam00350 936156000744 G2 box; other site 936156000745 Switch I region; other site 936156000746 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 936156000747 G3 box; other site 936156000748 Switch II region; other site 936156000749 GTP/Mg2+ binding site [chemical binding]; other site 936156000750 G4 box; other site 936156000751 G5 box; other site 936156000752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 936156000753 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 936156000754 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 936156000755 malonyl-CoA binding site [chemical binding]; other site 936156000756 dimer interface [polypeptide binding]; other site 936156000757 active site 936156000758 product binding site; other site 936156000759 xanthine permease; Region: pbuX; TIGR03173 936156000760 Sulfate transporter family; Region: Sulfate_transp; pfam00916 936156000761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936156000762 active site 936156000763 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 936156000764 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 936156000765 active site 936156000766 Zn binding site [ion binding]; other site 936156000767 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 936156000768 Entner-Doudoroff aldolase; Region: eda; TIGR01182 936156000769 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 936156000770 active site 936156000771 intersubunit interface [polypeptide binding]; other site 936156000772 catalytic residue [active] 936156000773 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936156000774 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 936156000775 substrate binding site [chemical binding]; other site 936156000776 ATP binding site [chemical binding]; other site 936156000777 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936156000778 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936156000779 DNA binding site [nucleotide binding] 936156000780 domain linker motif; other site 936156000781 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 936156000782 putative dimerization interface [polypeptide binding]; other site 936156000783 putative ligand binding site [chemical binding]; other site 936156000784 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 936156000785 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 936156000786 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 936156000787 NADP binding site [chemical binding]; other site 936156000788 homodimer interface [polypeptide binding]; other site 936156000789 active site 936156000790 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 936156000791 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 936156000792 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 936156000793 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 936156000794 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 936156000795 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 936156000796 cell division protein GpsB; Provisional; Region: PRK14127 936156000797 DivIVA domain; Region: DivI1A_domain; TIGR03544 936156000798 hypothetical protein; Provisional; Region: PRK13660 936156000799 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 936156000800 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 936156000801 RNase_H superfamily; Region: RNase_H_2; pfam13482 936156000802 active site 936156000803 substrate binding site [chemical binding]; other site 936156000804 Tetratricopeptide repeat; Region: TPR_16; pfam13432 936156000805 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 936156000806 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936156000807 ATP binding site [chemical binding]; other site 936156000808 putative Mg++ binding site [ion binding]; other site 936156000809 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156000810 nucleotide binding region [chemical binding]; other site 936156000811 ATP-binding site [chemical binding]; other site 936156000812 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 936156000813 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 936156000814 HPr interaction site; other site 936156000815 glycerol kinase (GK) interaction site [polypeptide binding]; other site 936156000816 active site 936156000817 phosphorylation site [posttranslational modification] 936156000818 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 936156000819 YppG-like protein; Region: YppG; pfam14179 936156000820 YppF-like protein; Region: YppF; pfam14178 936156000821 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 936156000822 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 936156000823 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 936156000824 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 936156000825 Transglycosylase; Region: Transgly; pfam00912 936156000826 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936156000827 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 936156000828 Interdomain contacts; other site 936156000829 Cytokine receptor motif; other site 936156000830 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 936156000831 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 936156000832 minor groove reading motif; other site 936156000833 helix-hairpin-helix signature motif; other site 936156000834 substrate binding pocket [chemical binding]; other site 936156000835 active site 936156000836 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 936156000837 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 936156000838 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 936156000839 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 936156000840 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 936156000841 putative dimer interface [polypeptide binding]; other site 936156000842 putative anticodon binding site; other site 936156000843 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 936156000844 homodimer interface [polypeptide binding]; other site 936156000845 motif 1; other site 936156000846 motif 2; other site 936156000847 active site 936156000848 motif 3; other site 936156000849 aspartate aminotransferase; Provisional; Region: PRK05764 936156000850 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156000851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156000852 homodimer interface [polypeptide binding]; other site 936156000853 catalytic residue [active] 936156000854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 936156000855 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 936156000856 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 936156000857 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 936156000858 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 936156000859 active site 936156000860 catalytic site [active] 936156000861 substrate binding site [chemical binding]; other site 936156000862 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 936156000863 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 936156000864 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 936156000865 tetramerization interface [polypeptide binding]; other site 936156000866 active site 936156000867 pantoate--beta-alanine ligase; Region: panC; TIGR00018 936156000868 Pantoate-beta-alanine ligase; Region: PanC; cd00560 936156000869 active site 936156000870 ATP-binding site [chemical binding]; other site 936156000871 pantoate-binding site; other site 936156000872 HXXH motif; other site 936156000873 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 936156000874 oligomerization interface [polypeptide binding]; other site 936156000875 active site 936156000876 metal binding site [ion binding]; metal-binding site 936156000877 Biotin operon repressor [Transcription]; Region: BirA; COG1654 936156000878 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 936156000879 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 936156000880 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 936156000881 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 936156000882 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 936156000883 active site 936156000884 NTP binding site [chemical binding]; other site 936156000885 metal binding triad [ion binding]; metal-binding site 936156000886 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 936156000887 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 936156000888 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 936156000889 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 936156000890 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 936156000891 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 936156000892 active site 936156000893 dimer interfaces [polypeptide binding]; other site 936156000894 catalytic residues [active] 936156000895 dihydrodipicolinate reductase; Region: dapB; TIGR00036 936156000896 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 936156000897 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 936156000898 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 936156000899 homodimer interface [polypeptide binding]; other site 936156000900 metal binding site [ion binding]; metal-binding site 936156000901 Uncharacterized conserved protein [Function unknown]; Region: COG1284 936156000902 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156000903 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156000904 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 936156000905 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 936156000906 Predicted membrane protein [Function unknown]; Region: COG4347 936156000907 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 936156000908 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 936156000909 intrachain domain interface; other site 936156000910 Qi binding site; other site 936156000911 Qo binding site; other site 936156000912 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 936156000913 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 936156000914 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 936156000915 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 936156000916 interchain domain interface [polypeptide binding]; other site 936156000917 intrachain domain interface; other site 936156000918 heme bH binding site [chemical binding]; other site 936156000919 Qi binding site; other site 936156000920 heme bL binding site [chemical binding]; other site 936156000921 Qo binding site; other site 936156000922 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 936156000923 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 936156000924 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 936156000925 iron-sulfur cluster [ion binding]; other site 936156000926 [2Fe-2S] cluster binding site [ion binding]; other site 936156000927 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 936156000928 hypothetical protein; Provisional; Region: PRK03636 936156000929 UPF0302 domain; Region: UPF0302; pfam08864 936156000930 IDEAL domain; Region: IDEAL; pfam08858 936156000931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156000932 TPR motif; other site 936156000933 binding surface 936156000934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156000935 binding surface 936156000936 TPR motif; other site 936156000937 Tetratricopeptide repeat; Region: TPR_16; pfam13432 936156000938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156000939 TPR motif; other site 936156000940 binding surface 936156000941 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 936156000942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156000943 binding surface 936156000944 TPR motif; other site 936156000945 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 936156000946 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 936156000947 hinge; other site 936156000948 active site 936156000949 prephenate dehydrogenase; Validated; Region: PRK06545 936156000950 prephenate dehydrogenase; Validated; Region: PRK08507 936156000951 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 936156000952 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 936156000953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156000954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156000955 homodimer interface [polypeptide binding]; other site 936156000956 catalytic residue [active] 936156000957 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 936156000958 substrate binding site [chemical binding]; other site 936156000959 active site 936156000960 catalytic residues [active] 936156000961 heterodimer interface [polypeptide binding]; other site 936156000962 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 936156000963 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 936156000964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156000965 catalytic residue [active] 936156000966 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 936156000967 active site 936156000968 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 936156000969 active site 936156000970 ribulose/triose binding site [chemical binding]; other site 936156000971 phosphate binding site [ion binding]; other site 936156000972 substrate (anthranilate) binding pocket [chemical binding]; other site 936156000973 product (indole) binding pocket [chemical binding]; other site 936156000974 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 936156000975 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 936156000976 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 936156000977 anthranilate synthase component I; Provisional; Region: PRK13569 936156000978 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 936156000979 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 936156000980 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 936156000981 homotrimer interaction site [polypeptide binding]; other site 936156000982 active site 936156000983 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 936156000984 active site 936156000985 dimer interface [polypeptide binding]; other site 936156000986 metal binding site [ion binding]; metal-binding site 936156000987 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 936156000988 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 936156000989 Tetramer interface [polypeptide binding]; other site 936156000990 active site 936156000991 FMN-binding site [chemical binding]; other site 936156000992 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 936156000993 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 936156000994 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 936156000995 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 936156000996 active site 936156000997 multimer interface [polypeptide binding]; other site 936156000998 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 936156000999 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 936156001000 substrate binding pocket [chemical binding]; other site 936156001001 chain length determination region; other site 936156001002 substrate-Mg2+ binding site; other site 936156001003 catalytic residues [active] 936156001004 aspartate-rich region 1; other site 936156001005 active site lid residues [active] 936156001006 aspartate-rich region 2; other site 936156001007 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 936156001008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156001009 S-adenosylmethionine binding site [chemical binding]; other site 936156001010 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 936156001011 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 936156001012 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 936156001013 homodecamer interface [polypeptide binding]; other site 936156001014 GTP cyclohydrolase I; Provisional; Region: PLN03044 936156001015 active site 936156001016 putative catalytic site residues [active] 936156001017 zinc binding site [ion binding]; other site 936156001018 GTP-CH-I/GFRP interaction surface; other site 936156001019 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 936156001020 IHF dimer interface [polypeptide binding]; other site 936156001021 IHF - DNA interface [nucleotide binding]; other site 936156001022 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 936156001023 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 936156001024 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 936156001025 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 936156001026 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 936156001027 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 936156001028 GTP-binding protein Der; Reviewed; Region: PRK00093 936156001029 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 936156001030 G1 box; other site 936156001031 GTP/Mg2+ binding site [chemical binding]; other site 936156001032 Switch I region; other site 936156001033 G2 box; other site 936156001034 Switch II region; other site 936156001035 G3 box; other site 936156001036 G4 box; other site 936156001037 G5 box; other site 936156001038 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 936156001039 G1 box; other site 936156001040 GTP/Mg2+ binding site [chemical binding]; other site 936156001041 Switch I region; other site 936156001042 G2 box; other site 936156001043 G3 box; other site 936156001044 Switch II region; other site 936156001045 G4 box; other site 936156001046 G5 box; other site 936156001047 YIEGIA protein; Region: YIEGIA; pfam14045 936156001048 YpzI-like protein; Region: YpzI; pfam14140 936156001049 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 936156001050 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 936156001051 homotetramer interface [polypeptide binding]; other site 936156001052 FMN binding site [chemical binding]; other site 936156001053 homodimer contacts [polypeptide binding]; other site 936156001054 putative active site [active] 936156001055 putative substrate binding site [chemical binding]; other site 936156001056 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 936156001057 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 936156001058 RNA binding site [nucleotide binding]; other site 936156001059 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 936156001060 RNA binding site [nucleotide binding]; other site 936156001061 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 936156001062 RNA binding site [nucleotide binding]; other site 936156001063 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 936156001064 RNA binding site [nucleotide binding]; other site 936156001065 cytidylate kinase; Provisional; Region: cmk; PRK00023 936156001066 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 936156001067 CMP-binding site; other site 936156001068 The sites determining sugar specificity; other site 936156001069 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 936156001070 Flagellar protein YcgR; Region: YcgR_2; pfam12945 936156001071 PilZ domain; Region: PilZ; pfam07238 936156001072 germination protein YpeB; Region: spore_YpeB; TIGR02889 936156001073 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 936156001074 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 936156001075 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 936156001076 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 936156001077 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 936156001078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936156001079 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 936156001080 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 936156001081 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 936156001082 NAD(P) binding site [chemical binding]; other site 936156001083 adaptor protein; Provisional; Region: PRK02899 936156001084 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 936156001085 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 936156001086 putative active site [active] 936156001087 putative metal binding site [ion binding]; other site 936156001088 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 936156001089 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156001090 CAAX protease self-immunity; Region: Abi; pfam02517 936156001091 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 936156001092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936156001093 ATP binding site [chemical binding]; other site 936156001094 putative Mg++ binding site [ion binding]; other site 936156001095 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156001096 nucleotide binding region [chemical binding]; other site 936156001097 ATP-binding site [chemical binding]; other site 936156001098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 936156001099 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 936156001100 Predicted membrane protein [Function unknown]; Region: COG3601 936156001101 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 936156001102 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 936156001103 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 936156001104 ligand binding site [chemical binding]; other site 936156001105 NAD binding site [chemical binding]; other site 936156001106 dimerization interface [polypeptide binding]; other site 936156001107 catalytic site [active] 936156001108 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 936156001109 putative L-serine binding site [chemical binding]; other site 936156001110 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 936156001111 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 936156001112 active site 936156001113 catalytic residue [active] 936156001114 dimer interface [polypeptide binding]; other site 936156001115 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 936156001116 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156001117 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156001118 DNA binding residues [nucleotide binding] 936156001119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 936156001120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936156001121 dimerization interface [polypeptide binding]; other site 936156001122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156001123 putative active site [active] 936156001124 heme pocket [chemical binding]; other site 936156001125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156001126 dimer interface [polypeptide binding]; other site 936156001127 phosphorylation site [posttranslational modification] 936156001128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156001129 ATP binding site [chemical binding]; other site 936156001130 Mg2+ binding site [ion binding]; other site 936156001131 G-X-G motif; other site 936156001132 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936156001133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156001134 active site 936156001135 phosphorylation site [posttranslational modification] 936156001136 intermolecular recognition site; other site 936156001137 dimerization interface [polypeptide binding]; other site 936156001138 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936156001139 DNA binding site [nucleotide binding] 936156001140 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 936156001141 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 936156001142 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 936156001143 ResB-like family; Region: ResB; pfam05140 936156001144 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 936156001145 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 936156001146 catalytic residues [active] 936156001147 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 936156001148 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936156001149 RNA binding surface [nucleotide binding]; other site 936156001150 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 936156001151 active site 936156001152 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 936156001153 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 936156001154 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 936156001155 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 936156001156 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 936156001157 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 936156001158 segregation and condensation protein B; Region: TIGR00281 936156001159 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 936156001160 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 936156001161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156001162 Coenzyme A binding pocket [chemical binding]; other site 936156001163 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 936156001164 homopentamer interface [polypeptide binding]; other site 936156001165 active site 936156001166 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 936156001167 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 936156001168 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 936156001169 dimerization interface [polypeptide binding]; other site 936156001170 active site 936156001171 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 936156001172 Lumazine binding domain; Region: Lum_binding; pfam00677 936156001173 Lumazine binding domain; Region: Lum_binding; pfam00677 936156001174 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 936156001175 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 936156001176 catalytic motif [active] 936156001177 Zn binding site [ion binding]; other site 936156001178 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 936156001179 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 936156001180 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 936156001181 Catalytic site [active] 936156001182 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 936156001183 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 936156001184 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 936156001185 active site 936156001186 Bacterial SH3 domain; Region: SH3_3; pfam08239 936156001187 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 936156001188 active site 936156001189 Predicted secreted protein [Function unknown]; Region: COG4086 936156001190 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 936156001191 diaminopimelate decarboxylase; Region: lysA; TIGR01048 936156001192 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 936156001193 active site 936156001194 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936156001195 substrate binding site [chemical binding]; other site 936156001196 catalytic residues [active] 936156001197 dimer interface [polypeptide binding]; other site 936156001198 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 936156001199 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 936156001200 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 936156001201 stage V sporulation protein AD; Validated; Region: PRK08304 936156001202 stage V sporulation protein AD; Provisional; Region: PRK12404 936156001203 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 936156001204 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 936156001205 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 936156001206 sporulation sigma factor SigF; Validated; Region: PRK05572 936156001207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156001208 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 936156001209 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156001210 DNA binding residues [nucleotide binding] 936156001211 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 936156001212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156001213 ATP binding site [chemical binding]; other site 936156001214 Mg2+ binding site [ion binding]; other site 936156001215 G-X-G motif; other site 936156001216 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 936156001217 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 936156001218 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 936156001219 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 936156001220 purine nucleoside phosphorylase; Provisional; Region: PRK08202 936156001221 phosphopentomutase; Provisional; Region: PRK05362 936156001222 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 936156001223 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 936156001224 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 936156001225 active site 936156001226 Int/Topo IB signature motif; other site 936156001227 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 936156001228 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 936156001229 metal binding site 2 [ion binding]; metal-binding site 936156001230 putative DNA binding helix; other site 936156001231 metal binding site 1 [ion binding]; metal-binding site 936156001232 dimer interface [polypeptide binding]; other site 936156001233 structural Zn2+ binding site [ion binding]; other site 936156001234 stage II sporulation protein M; Region: spo_II_M; TIGR02831 936156001235 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 936156001236 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 936156001237 Malic enzyme, N-terminal domain; Region: malic; pfam00390 936156001238 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 936156001239 NAD(P) binding pocket [chemical binding]; other site 936156001240 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 936156001241 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 936156001242 Aspartase; Region: Aspartase; cd01357 936156001243 active sites [active] 936156001244 tetramer interface [polypeptide binding]; other site 936156001245 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 936156001246 active site 936156001247 homodimer interface [polypeptide binding]; other site 936156001248 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936156001249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156001250 non-specific DNA binding site [nucleotide binding]; other site 936156001251 salt bridge; other site 936156001252 sequence-specific DNA binding site [nucleotide binding]; other site 936156001253 TIGR00375 family protein; Region: TIGR00375 936156001254 PHP-associated; Region: PHP_C; pfam13263 936156001255 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 936156001256 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 936156001257 dimer interface [polypeptide binding]; other site 936156001258 ADP-ribose binding site [chemical binding]; other site 936156001259 active site 936156001260 nudix motif; other site 936156001261 metal binding site [ion binding]; metal-binding site 936156001262 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 936156001263 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936156001264 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936156001265 active site 936156001266 catalytic tetrad [active] 936156001267 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 936156001268 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 936156001269 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 936156001270 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 936156001271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 936156001272 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 936156001273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156001274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 936156001275 Coenzyme A binding pocket [chemical binding]; other site 936156001276 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 936156001277 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 936156001278 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 936156001279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156001280 Coenzyme A binding pocket [chemical binding]; other site 936156001281 YolD-like protein; Region: YolD; pfam08863 936156001282 DNA polymerase IV; Reviewed; Region: PRK03103 936156001283 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 936156001284 active site 936156001285 DNA binding site [nucleotide binding] 936156001286 YqzH-like protein; Region: YqzH; pfam14164 936156001287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156001288 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156001289 putative substrate translocation pore; other site 936156001290 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 936156001291 putative dimer interface [polypeptide binding]; other site 936156001292 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156001293 ligand binding site [chemical binding]; other site 936156001294 Zn binding site [ion binding]; other site 936156001295 pantothenate kinase; Provisional; Region: PRK05439 936156001296 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 936156001297 ATP-binding site [chemical binding]; other site 936156001298 CoA-binding site [chemical binding]; other site 936156001299 Mg2+-binding site [ion binding]; other site 936156001300 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 936156001301 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936156001302 catalytic residue [active] 936156001303 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 936156001304 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 936156001305 NADP binding site [chemical binding]; other site 936156001306 homodimer interface [polypeptide binding]; other site 936156001307 substrate binding site [chemical binding]; other site 936156001308 active site 936156001309 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 936156001310 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 936156001311 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 936156001312 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 936156001313 putative metal binding site [ion binding]; other site 936156001314 putative dimer interface [polypeptide binding]; other site 936156001315 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 936156001316 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 936156001317 active site 936156001318 FMN binding site [chemical binding]; other site 936156001319 substrate binding site [chemical binding]; other site 936156001320 homotetramer interface [polypeptide binding]; other site 936156001321 catalytic residue [active] 936156001322 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 936156001323 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 936156001324 putative hydrolase; Provisional; Region: PRK02113 936156001325 ribonuclease Z; Region: RNase_Z; TIGR02651 936156001326 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 936156001327 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 936156001328 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 936156001329 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 936156001330 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 936156001331 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 936156001332 DNA polymerase IV; Validated; Region: PRK01810 936156001333 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 936156001334 active site 936156001335 DNA binding site [nucleotide binding] 936156001336 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 936156001337 OxaA-like protein precursor; Validated; Region: PRK01622 936156001338 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 936156001339 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 936156001340 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 936156001341 peptidase T-like protein; Region: PepT-like; TIGR01883 936156001342 metal binding site [ion binding]; metal-binding site 936156001343 putative dimer interface [polypeptide binding]; other site 936156001344 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 936156001345 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 936156001346 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 936156001347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156001348 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 936156001349 dimer interface [polypeptide binding]; other site 936156001350 substrate binding site [chemical binding]; other site 936156001351 metal binding site [ion binding]; metal-binding site 936156001352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 936156001353 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 936156001354 Predicted membrane protein [Function unknown]; Region: COG4129 936156001355 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 936156001356 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 936156001357 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 936156001358 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 936156001359 Walker A/P-loop; other site 936156001360 ATP binding site [chemical binding]; other site 936156001361 Q-loop/lid; other site 936156001362 ABC transporter signature motif; other site 936156001363 Walker B; other site 936156001364 D-loop; other site 936156001365 H-loop/switch region; other site 936156001366 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 936156001367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156001368 dimer interface [polypeptide binding]; other site 936156001369 conserved gate region; other site 936156001370 putative PBP binding loops; other site 936156001371 ABC-ATPase subunit interface; other site 936156001372 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936156001373 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 936156001374 substrate binding pocket [chemical binding]; other site 936156001375 membrane-bound complex binding site; other site 936156001376 hinge residues; other site 936156001377 Disulphide isomerase; Region: Disulph_isomer; pfam06491 936156001378 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 936156001379 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 936156001380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156001381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156001382 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 936156001383 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 936156001384 DNA binding residues [nucleotide binding] 936156001385 drug binding residues [chemical binding]; other site 936156001386 dimer interface [polypeptide binding]; other site 936156001387 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 936156001388 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 936156001389 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 936156001390 E3 interaction surface; other site 936156001391 lipoyl attachment site [posttranslational modification]; other site 936156001392 e3 binding domain; Region: E3_binding; pfam02817 936156001393 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 936156001394 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 936156001395 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 936156001396 alpha subunit interface [polypeptide binding]; other site 936156001397 TPP binding site [chemical binding]; other site 936156001398 heterodimer interface [polypeptide binding]; other site 936156001399 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 936156001400 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 936156001401 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 936156001402 tetramer interface [polypeptide binding]; other site 936156001403 TPP-binding site [chemical binding]; other site 936156001404 heterodimer interface [polypeptide binding]; other site 936156001405 phosphorylation loop region [posttranslational modification] 936156001406 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 936156001407 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 936156001408 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936156001409 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 936156001410 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936156001411 nucleotide binding site [chemical binding]; other site 936156001412 Acetokinase family; Region: Acetate_kinase; cl17229 936156001413 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 936156001414 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 936156001415 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 936156001416 NAD binding site [chemical binding]; other site 936156001417 Phe binding site; other site 936156001418 phosphate butyryltransferase; Validated; Region: PRK07742 936156001419 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 936156001420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156001421 putative active site [active] 936156001422 heme pocket [chemical binding]; other site 936156001423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156001424 putative active site [active] 936156001425 heme pocket [chemical binding]; other site 936156001426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156001427 Walker A motif; other site 936156001428 ATP binding site [chemical binding]; other site 936156001429 Walker B motif; other site 936156001430 arginine finger; other site 936156001431 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 936156001432 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 936156001433 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 936156001434 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 936156001435 tetramer interface [polypeptide binding]; other site 936156001436 active site 936156001437 Mg2+/Mn2+ binding site [ion binding]; other site 936156001438 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 936156001439 2-methylcitrate dehydratase; Region: prpD; TIGR02330 936156001440 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 936156001441 dimer interface [polypeptide binding]; other site 936156001442 Citrate synthase; Region: Citrate_synt; pfam00285 936156001443 active site 936156001444 coenzyme A binding site [chemical binding]; other site 936156001445 citrylCoA binding site [chemical binding]; other site 936156001446 oxalacetate/citrate binding site [chemical binding]; other site 936156001447 catalytic triad [active] 936156001448 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 936156001449 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 936156001450 FAD binding site [chemical binding]; other site 936156001451 homotetramer interface [polypeptide binding]; other site 936156001452 substrate binding pocket [chemical binding]; other site 936156001453 catalytic base [active] 936156001454 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 936156001455 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 936156001456 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 936156001457 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 936156001458 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 936156001459 dimer interface [polypeptide binding]; other site 936156001460 active site 936156001461 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 936156001462 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 936156001463 active site 936156001464 catalytic site [active] 936156001465 metal binding site [ion binding]; metal-binding site 936156001466 dimer interface [polypeptide binding]; other site 936156001467 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 936156001468 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 936156001469 active site 936156001470 metal binding site [ion binding]; metal-binding site 936156001471 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 936156001472 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 936156001473 putative active site [active] 936156001474 putative FMN binding site [chemical binding]; other site 936156001475 putative substrate binding site [chemical binding]; other site 936156001476 putative catalytic residue [active] 936156001477 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 936156001478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156001479 active site 936156001480 phosphorylation site [posttranslational modification] 936156001481 intermolecular recognition site; other site 936156001482 dimerization interface [polypeptide binding]; other site 936156001483 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 936156001484 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 936156001485 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 936156001486 protein binding site [polypeptide binding]; other site 936156001487 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 936156001488 DNA repair protein RecN; Region: recN; TIGR00634 936156001489 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 936156001490 Walker A/P-loop; other site 936156001491 ATP binding site [chemical binding]; other site 936156001492 Q-loop/lid; other site 936156001493 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 936156001494 ABC transporter signature motif; other site 936156001495 Walker B; other site 936156001496 D-loop; other site 936156001497 H-loop/switch region; other site 936156001498 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 936156001499 arginine repressor; Provisional; Region: PRK04280 936156001500 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 936156001501 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 936156001502 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936156001503 RNA binding surface [nucleotide binding]; other site 936156001504 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 936156001505 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 936156001506 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 936156001507 TPP-binding site; other site 936156001508 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 936156001509 PYR/PP interface [polypeptide binding]; other site 936156001510 dimer interface [polypeptide binding]; other site 936156001511 TPP binding site [chemical binding]; other site 936156001512 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 936156001513 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 936156001514 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 936156001515 substrate binding pocket [chemical binding]; other site 936156001516 chain length determination region; other site 936156001517 substrate-Mg2+ binding site; other site 936156001518 catalytic residues [active] 936156001519 aspartate-rich region 1; other site 936156001520 active site lid residues [active] 936156001521 aspartate-rich region 2; other site 936156001522 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 936156001523 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 936156001524 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 936156001525 generic binding surface II; other site 936156001526 generic binding surface I; other site 936156001527 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 936156001528 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 936156001529 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 936156001530 homodimer interface [polypeptide binding]; other site 936156001531 NADP binding site [chemical binding]; other site 936156001532 substrate binding site [chemical binding]; other site 936156001533 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 936156001534 putative RNA binding site [nucleotide binding]; other site 936156001535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 936156001536 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 936156001537 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936156001538 ATP-grasp domain; Region: ATP-grasp_4; cl17255 936156001539 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 936156001540 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 936156001541 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 936156001542 carboxyltransferase (CT) interaction site; other site 936156001543 biotinylation site [posttranslational modification]; other site 936156001544 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 936156001545 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 936156001546 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 936156001547 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 936156001548 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 936156001549 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 936156001550 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 936156001551 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 936156001552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156001553 Walker A motif; other site 936156001554 ATP binding site [chemical binding]; other site 936156001555 Walker B motif; other site 936156001556 arginine finger; other site 936156001557 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 936156001558 elongation factor P; Validated; Region: PRK00529 936156001559 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 936156001560 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 936156001561 RNA binding site [nucleotide binding]; other site 936156001562 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 936156001563 RNA binding site [nucleotide binding]; other site 936156001564 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 936156001565 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 936156001566 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 936156001567 active site 936156001568 Dehydroquinase class II; Region: DHquinase_II; pfam01220 936156001569 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 936156001570 trimer interface [polypeptide binding]; other site 936156001571 active site 936156001572 dimer interface [polypeptide binding]; other site 936156001573 Conserved membrane protein YqhR; Region: YqhR; pfam11085 936156001574 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 936156001575 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 936156001576 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 936156001577 active site 936156001578 nucleophile elbow; other site 936156001579 manganese transport transcriptional regulator; Provisional; Region: PRK03902 936156001580 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 936156001581 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 936156001582 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 936156001583 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 936156001584 active site residue [active] 936156001585 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 936156001586 tetramer interface [polypeptide binding]; other site 936156001587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156001588 catalytic residue [active] 936156001589 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 936156001590 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 936156001591 tetramer interface [polypeptide binding]; other site 936156001592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156001593 catalytic residue [active] 936156001594 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 936156001595 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 936156001596 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 936156001597 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 936156001598 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936156001599 ATP binding site [chemical binding]; other site 936156001600 putative Mg++ binding site [ion binding]; other site 936156001601 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156001602 nucleotide binding region [chemical binding]; other site 936156001603 ATP-binding site [chemical binding]; other site 936156001604 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 936156001605 Anti-repressor SinI; Region: SinI; pfam08671 936156001606 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936156001607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156001608 non-specific DNA binding site [nucleotide binding]; other site 936156001609 salt bridge; other site 936156001610 sequence-specific DNA binding site [nucleotide binding]; other site 936156001611 Anti-repressor SinI; Region: SinI; pfam08671 936156001612 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 936156001613 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 936156001614 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 936156001615 Catalytic site [active] 936156001616 YqxM protein; Region: YqxM_for_SipW; TIGR04087 936156001617 Merozoite surface protein (SPAM); Region: Merozoite_SPAM; pfam07133 936156001618 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 936156001619 YqzE-like protein; Region: YqzE; pfam14038 936156001620 ComG operon protein 7; Region: ComGG; pfam14173 936156001621 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 936156001622 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 936156001623 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 936156001624 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 936156001625 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 936156001626 Type II/IV secretion system protein; Region: T2SE; pfam00437 936156001627 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 936156001628 Walker A motif; other site 936156001629 ATP binding site [chemical binding]; other site 936156001630 Walker B motif; other site 936156001631 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 936156001632 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 936156001633 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 936156001634 Cl binding site [ion binding]; other site 936156001635 oligomer interface [polypeptide binding]; other site 936156001636 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 936156001637 Domain of unknown function DUF21; Region: DUF21; pfam01595 936156001638 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 936156001639 Transporter associated domain; Region: CorC_HlyC; smart01091 936156001640 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 936156001641 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 936156001642 ArsC family; Region: ArsC; pfam03960 936156001643 putative catalytic residues [active] 936156001644 thiol/disulfide switch; other site 936156001645 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 936156001646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 936156001647 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 936156001648 Domain of unknown function DUF77; Region: DUF77; pfam01910 936156001649 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 936156001650 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 936156001651 putative active site [active] 936156001652 Zn binding site [ion binding]; other site 936156001653 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 936156001654 Sulfatase; Region: Sulfatase; pfam00884 936156001655 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 936156001656 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936156001657 nucleotide binding site [chemical binding]; other site 936156001658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 936156001659 Rhomboid family; Region: Rhomboid; pfam01694 936156001660 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156001661 binding surface 936156001662 TPR motif; other site 936156001663 TPR repeat; Region: TPR_11; pfam13414 936156001664 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 936156001665 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 936156001666 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 936156001667 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936156001668 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 936156001669 YceG-like family; Region: YceG; pfam02618 936156001670 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 936156001671 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 936156001672 Walker A/P-loop; other site 936156001673 ATP binding site [chemical binding]; other site 936156001674 Q-loop/lid; other site 936156001675 ABC transporter signature motif; other site 936156001676 Walker B; other site 936156001677 D-loop; other site 936156001678 H-loop/switch region; other site 936156001679 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 936156001680 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 936156001681 Walker A/P-loop; other site 936156001682 ATP binding site [chemical binding]; other site 936156001683 Q-loop/lid; other site 936156001684 ABC transporter signature motif; other site 936156001685 Walker B; other site 936156001686 D-loop; other site 936156001687 H-loop/switch region; other site 936156001688 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 936156001689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156001690 dimer interface [polypeptide binding]; other site 936156001691 conserved gate region; other site 936156001692 ABC-ATPase subunit interface; other site 936156001693 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 936156001694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156001695 dimer interface [polypeptide binding]; other site 936156001696 conserved gate region; other site 936156001697 putative PBP binding loops; other site 936156001698 ABC-ATPase subunit interface; other site 936156001699 PBP superfamily domain; Region: PBP_like_2; cl17296 936156001700 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 936156001701 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 936156001702 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 936156001703 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936156001704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156001705 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156001706 putative substrate translocation pore; other site 936156001707 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 936156001708 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 936156001709 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 936156001710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 936156001711 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 936156001712 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156001713 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 936156001714 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 936156001715 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 936156001716 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 936156001717 Uncharacterized conserved protein [Function unknown]; Region: COG5663 936156001718 ferric uptake regulator; Provisional; Region: fur; PRK09462 936156001719 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 936156001720 metal binding site 2 [ion binding]; metal-binding site 936156001721 putative DNA binding helix; other site 936156001722 metal binding site 1 [ion binding]; metal-binding site 936156001723 dimer interface [polypeptide binding]; other site 936156001724 structural Zn2+ binding site [ion binding]; other site 936156001725 Uncharacterized conserved protein [Function unknown]; Region: COG1284 936156001726 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156001727 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156001728 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 936156001729 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 936156001730 endonuclease IV; Provisional; Region: PRK01060 936156001731 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 936156001732 AP (apurinic/apyrimidinic) site pocket; other site 936156001733 DNA interaction; other site 936156001734 Metal-binding active site; metal-binding site 936156001735 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 936156001736 DEAD-like helicases superfamily; Region: DEXDc; smart00487 936156001737 ATP binding site [chemical binding]; other site 936156001738 Mg++ binding site [ion binding]; other site 936156001739 motif III; other site 936156001740 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156001741 nucleotide binding region [chemical binding]; other site 936156001742 ATP-binding site [chemical binding]; other site 936156001743 YqfQ-like protein; Region: YqfQ; pfam14181 936156001744 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 936156001745 LytB protein; Region: LYTB; pfam02401 936156001746 Uncharacterized conserved protein [Function unknown]; Region: COG0327 936156001747 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 936156001748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 936156001749 Uncharacterized conserved protein [Function unknown]; Region: COG0327 936156001750 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 936156001751 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 936156001752 Family of unknown function (DUF633); Region: DUF633; pfam04816 936156001753 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 936156001754 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 936156001755 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 936156001756 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 936156001757 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 936156001758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156001759 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 936156001760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156001761 DNA binding residues [nucleotide binding] 936156001762 DNA primase; Validated; Region: dnaG; PRK05667 936156001763 CHC2 zinc finger; Region: zf-CHC2; pfam01807 936156001764 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 936156001765 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 936156001766 active site 936156001767 metal binding site [ion binding]; metal-binding site 936156001768 interdomain interaction site; other site 936156001769 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 936156001770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 936156001771 PEP synthetase regulatory protein; Provisional; Region: PRK05339 936156001772 HTH domain; Region: HTH_11; pfam08279 936156001773 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 936156001774 FOG: CBS domain [General function prediction only]; Region: COG0517 936156001775 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 936156001776 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 936156001777 dimer interface [polypeptide binding]; other site 936156001778 motif 1; other site 936156001779 active site 936156001780 motif 2; other site 936156001781 motif 3; other site 936156001782 Recombination protein O N terminal; Region: RecO_N; pfam11967 936156001783 DNA repair protein RecO; Region: reco; TIGR00613 936156001784 Recombination protein O C terminal; Region: RecO_C; pfam02565 936156001785 YqzL-like protein; Region: YqzL; pfam14006 936156001786 GTPase Era; Reviewed; Region: era; PRK00089 936156001787 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 936156001788 G1 box; other site 936156001789 GTP/Mg2+ binding site [chemical binding]; other site 936156001790 Switch I region; other site 936156001791 G2 box; other site 936156001792 Switch II region; other site 936156001793 G3 box; other site 936156001794 G4 box; other site 936156001795 G5 box; other site 936156001796 KH domain; Region: KH_2; pfam07650 936156001797 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 936156001798 active site 936156001799 catalytic motif [active] 936156001800 Zn binding site [ion binding]; other site 936156001801 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 936156001802 metal-binding heat shock protein; Provisional; Region: PRK00016 936156001803 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 936156001804 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 936156001805 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936156001806 Zn2+ binding site [ion binding]; other site 936156001807 Mg2+ binding site [ion binding]; other site 936156001808 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 936156001809 PhoH-like protein; Region: PhoH; pfam02562 936156001810 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 936156001811 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 936156001812 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 936156001813 hypothetical protein; Provisional; Region: PRK13665 936156001814 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 936156001815 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 936156001816 dimer interface [polypeptide binding]; other site 936156001817 active site residues [active] 936156001818 Yqey-like protein; Region: YqeY; pfam09424 936156001819 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 936156001820 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 936156001821 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 936156001822 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 936156001823 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 936156001824 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 936156001825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936156001826 FeS/SAM binding site; other site 936156001827 TRAM domain; Region: TRAM; cl01282 936156001828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 936156001829 RNA methyltransferase, RsmE family; Region: TIGR00046 936156001830 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 936156001831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156001832 S-adenosylmethionine binding site [chemical binding]; other site 936156001833 chaperone protein DnaJ; Provisional; Region: PRK14280 936156001834 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 936156001835 HSP70 interaction site [polypeptide binding]; other site 936156001836 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 936156001837 substrate binding site [polypeptide binding]; other site 936156001838 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 936156001839 Zn binding sites [ion binding]; other site 936156001840 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 936156001841 dimer interface [polypeptide binding]; other site 936156001842 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 936156001843 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 936156001844 nucleotide binding site [chemical binding]; other site 936156001845 NEF interaction site [polypeptide binding]; other site 936156001846 SBD interface [polypeptide binding]; other site 936156001847 GrpE; Region: GrpE; pfam01025 936156001848 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 936156001849 dimer interface [polypeptide binding]; other site 936156001850 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 936156001851 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 936156001852 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 936156001853 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 936156001854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936156001855 FeS/SAM binding site; other site 936156001856 HemN C-terminal domain; Region: HemN_C; pfam06969 936156001857 GTP-binding protein LepA; Provisional; Region: PRK05433 936156001858 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 936156001859 G1 box; other site 936156001860 putative GEF interaction site [polypeptide binding]; other site 936156001861 GTP/Mg2+ binding site [chemical binding]; other site 936156001862 Switch I region; other site 936156001863 G2 box; other site 936156001864 G3 box; other site 936156001865 Switch II region; other site 936156001866 G4 box; other site 936156001867 G5 box; other site 936156001868 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 936156001869 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 936156001870 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 936156001871 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 936156001872 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 936156001873 stage II sporulation protein P; Region: spore_II_P; TIGR02867 936156001874 germination protease; Provisional; Region: PRK02858 936156001875 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 936156001876 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 936156001877 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 936156001878 YqzM-like protein; Region: YqzM; pfam14141 936156001879 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 936156001880 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 936156001881 Competence protein; Region: Competence; pfam03772 936156001882 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 936156001883 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 936156001884 catalytic motif [active] 936156001885 Zn binding site [ion binding]; other site 936156001886 SLBB domain; Region: SLBB; pfam10531 936156001887 comEA protein; Region: comE; TIGR01259 936156001888 Helix-hairpin-helix motif; Region: HHH; pfam00633 936156001889 late competence protein ComER; Validated; Region: PRK07680 936156001890 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 936156001891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156001892 S-adenosylmethionine binding site [chemical binding]; other site 936156001893 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 936156001894 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936156001895 Zn2+ binding site [ion binding]; other site 936156001896 Mg2+ binding site [ion binding]; other site 936156001897 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 936156001898 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 936156001899 active site 936156001900 (T/H)XGH motif; other site 936156001901 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 936156001902 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 936156001903 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 936156001904 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 936156001905 shikimate binding site; other site 936156001906 NAD(P) binding site [chemical binding]; other site 936156001907 GTPase YqeH; Provisional; Region: PRK13796 936156001908 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 936156001909 GTP/Mg2+ binding site [chemical binding]; other site 936156001910 G4 box; other site 936156001911 G5 box; other site 936156001912 G1 box; other site 936156001913 Switch I region; other site 936156001914 G2 box; other site 936156001915 G3 box; other site 936156001916 Switch II region; other site 936156001917 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 936156001918 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156001919 active site 936156001920 motif I; other site 936156001921 motif II; other site 936156001922 Sporulation inhibitor A; Region: Sda; pfam08970 936156001923 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 936156001924 active site 936156001925 catalytic triad [active] 936156001926 oxyanion hole [active] 936156001927 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 936156001928 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 936156001929 amidase catalytic site [active] 936156001930 Zn binding residues [ion binding]; other site 936156001931 substrate binding site [chemical binding]; other site 936156001932 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 936156001933 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 936156001934 Uncharacterized conserved protein [Function unknown]; Region: COG0398 936156001935 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 936156001936 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 936156001937 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 936156001938 arginine decarboxylase; Provisional; Region: PRK15029 936156001939 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 936156001940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156001941 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 936156001942 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 936156001943 catalytic residues [active] 936156001944 Recombinase; Region: Recombinase; pfam07508 936156001945 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 936156001946 Low molecular weight phosphatase family; Region: LMWPc; cd00115 936156001947 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 936156001948 active site 936156001949 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 936156001950 arsenical-resistance protein; Region: acr3; TIGR00832 936156001951 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 936156001952 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156001953 putative metal binding site [ion binding]; other site 936156001954 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156001955 dimerization interface [polypeptide binding]; other site 936156001956 putative DNA binding site [nucleotide binding]; other site 936156001957 putative Zn2+ binding site [ion binding]; other site 936156001958 Uncharacterized conserved protein [Function unknown]; Region: COG3403 936156001959 YtkA-like; Region: YtkA; pfam13115 936156001960 potential frameshift: common BLAST hit: gi|172056330|ref|YP_001812790.1| PepSY-associated TM helix domain-containing protein 936156001961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156001962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156001963 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 936156001964 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 936156001965 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 936156001966 putative NADP binding site [chemical binding]; other site 936156001967 putative dimer interface [polypeptide binding]; other site 936156001968 C1q domain; Region: C1q; cl17543 936156001969 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 936156001970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156001971 binding surface 936156001972 TPR motif; other site 936156001973 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156001974 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156001975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156001976 TPR motif; other site 936156001977 binding surface 936156001978 TPR repeat; Region: TPR_11; pfam13414 936156001979 Uncharacterized conserved protein [Function unknown]; Region: COG5444 936156001980 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 936156001981 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 936156001982 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 936156001983 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 936156001984 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 936156001985 amidase catalytic site [active] 936156001986 Zn binding residues [ion binding]; other site 936156001987 substrate binding site [chemical binding]; other site 936156001988 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 936156001989 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 936156001990 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 936156001991 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 936156001992 XkdW protein; Region: XkdW; pfam09636 936156001993 C1q domain; Region: C1q; cl17543 936156001994 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 936156001995 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 936156001996 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 936156001997 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 936156001998 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 936156001999 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 936156002000 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156002001 Phage-related minor tail protein [Function unknown]; Region: COG5280 936156002002 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 936156002003 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936156002004 catalytic residue [active] 936156002005 Phage XkdN-like protein; Region: XkdN; pfam08890 936156002006 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 936156002007 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 936156002008 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 936156002009 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 936156002010 Phage capsid family; Region: Phage_capsid; pfam05065 936156002011 The Phox Homology domain, a phosphoinositide binding module; Region: PX_domain; cl02563 936156002012 phosphoinositide binding site [chemical binding]; other site 936156002013 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 936156002014 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 936156002015 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 936156002016 Uncharacterized conserved protein [Function unknown]; Region: COG5484 936156002017 Helix-turn-helix domain; Region: HTH_28; pfam13518 936156002018 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 936156002019 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 936156002020 cofactor binding site; other site 936156002021 DNA binding site [nucleotide binding] 936156002022 substrate interaction site [chemical binding]; other site 936156002023 SacI restriction endonuclease; Region: RE_SacI; pfam09566 936156002024 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 936156002025 hypothetical protein; Provisional; Region: PRK06921 936156002026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156002027 Walker A motif; other site 936156002028 ATP binding site [chemical binding]; other site 936156002029 Walker B motif; other site 936156002030 arginine finger; other site 936156002031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 936156002032 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 936156002033 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 936156002034 Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377 936156002035 Hypothetical protein Yqai; Region: Yqai; pfam09466 936156002036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156002037 non-specific DNA binding site [nucleotide binding]; other site 936156002038 salt bridge; other site 936156002039 sequence-specific DNA binding site [nucleotide binding]; other site 936156002040 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936156002041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156002042 non-specific DNA binding site [nucleotide binding]; other site 936156002043 salt bridge; other site 936156002044 sequence-specific DNA binding site [nucleotide binding]; other site 936156002045 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936156002046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156002047 non-specific DNA binding site [nucleotide binding]; other site 936156002048 salt bridge; other site 936156002049 sequence-specific DNA binding site [nucleotide binding]; other site 936156002050 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 936156002051 hypothetical protein; Validated; Region: PRK06217 936156002052 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 936156002053 Domain of unknown function (DUF955); Region: DUF955; pfam06114 936156002054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156002055 DNA binding residues [nucleotide binding] 936156002056 tetracycline repressor protein TetR; Provisional; Region: PRK13756 936156002057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156002058 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 936156002059 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 936156002060 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 936156002061 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 936156002062 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 936156002063 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 936156002064 CPxP motif; other site 936156002065 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 936156002066 active site residue [active] 936156002067 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 936156002068 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 936156002069 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 936156002070 CPxP motif; other site 936156002071 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 936156002072 active site residue [active] 936156002073 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 936156002074 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 936156002075 putative homodimer interface [polypeptide binding]; other site 936156002076 putative homotetramer interface [polypeptide binding]; other site 936156002077 putative metal binding site [ion binding]; other site 936156002078 putative homodimer-homodimer interface [polypeptide binding]; other site 936156002079 putative allosteric switch controlling residues; other site 936156002080 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 936156002081 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 936156002082 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 936156002083 DNA binding residues [nucleotide binding] 936156002084 dimer interface [polypeptide binding]; other site 936156002085 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 936156002086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156002087 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156002088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156002089 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 936156002090 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 936156002091 Coenzyme A binding pocket [chemical binding]; other site 936156002092 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 936156002093 Domain of unknown function DUF21; Region: DUF21; pfam01595 936156002094 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 936156002095 Transporter associated domain; Region: CorC_HlyC; smart01091 936156002096 YrzO-like protein; Region: YrzO; pfam14142 936156002097 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 936156002098 EamA-like transporter family; Region: EamA; pfam00892 936156002099 EamA-like transporter family; Region: EamA; pfam00892 936156002100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156002101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156002102 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 936156002103 putative dimerization interface [polypeptide binding]; other site 936156002104 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 936156002105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 936156002106 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 936156002107 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 936156002108 Tautomerase enzyme; Region: Tautomerase; pfam01361 936156002109 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156002110 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 936156002111 putative dimerization interface [polypeptide binding]; other site 936156002112 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 936156002113 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 936156002114 4-azaleucine resistance probable transporter AzlC; Region: azlC; TIGR00346 936156002115 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 936156002116 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156002117 putative DNA binding site [nucleotide binding]; other site 936156002118 putative Zn2+ binding site [ion binding]; other site 936156002119 AsnC family; Region: AsnC_trans_reg; pfam01037 936156002120 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 936156002121 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 936156002122 Cytochrome P450; Region: p450; cl12078 936156002123 Isochorismatase family; Region: Isochorismatase; pfam00857 936156002124 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 936156002125 catalytic triad [active] 936156002126 conserved cis-peptide bond; other site 936156002127 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 936156002128 DinB family; Region: DinB; pfam05163 936156002129 DinB superfamily; Region: DinB_2; pfam12867 936156002130 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 936156002131 Nitronate monooxygenase; Region: NMO; pfam03060 936156002132 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 936156002133 FMN binding site [chemical binding]; other site 936156002134 substrate binding site [chemical binding]; other site 936156002135 putative catalytic residue [active] 936156002136 glutamate racemase; Region: glut_race; TIGR00067 936156002137 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 936156002138 putative binding site; other site 936156002139 putative dimer interface [polypeptide binding]; other site 936156002140 Transcriptional regulators [Transcription]; Region: FadR; COG2186 936156002141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156002142 DNA-binding site [nucleotide binding]; DNA binding site 936156002143 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 936156002144 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 936156002145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156002146 D-galactonate transporter; Region: 2A0114; TIGR00893 936156002147 putative substrate translocation pore; other site 936156002148 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 936156002149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 936156002150 NAD(P) binding site [chemical binding]; other site 936156002151 active site 936156002152 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 936156002153 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 936156002154 PYR/PP interface [polypeptide binding]; other site 936156002155 dimer interface [polypeptide binding]; other site 936156002156 TPP binding site [chemical binding]; other site 936156002157 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 936156002158 transketolase; Reviewed; Region: PRK05899 936156002159 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 936156002160 TPP-binding site [chemical binding]; other site 936156002161 dimer interface [polypeptide binding]; other site 936156002162 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 936156002163 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 936156002164 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 936156002165 DNA binding residues [nucleotide binding] 936156002166 drug binding residues [chemical binding]; other site 936156002167 dimer interface [polypeptide binding]; other site 936156002168 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 936156002169 Protein of unknown function (DUF419); Region: DUF419; pfam04237 936156002170 YodA lipocalin-like domain; Region: YodA; pfam09223 936156002171 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 936156002172 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156002173 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156002174 DNA binding residues [nucleotide binding] 936156002175 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936156002176 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936156002177 active site 936156002178 catalytic tetrad [active] 936156002179 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 936156002180 Citrate transporter; Region: CitMHS; pfam03600 936156002181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156002182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156002183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936156002184 dimerization interface [polypeptide binding]; other site 936156002185 PrpF protein; Region: PrpF; pfam04303 936156002186 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 936156002187 chitosan binding site [chemical binding]; other site 936156002188 catalytic residues [active] 936156002189 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 936156002190 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 936156002191 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 936156002192 Bacterial SH3 domain homologues; Region: SH3b; smart00287 936156002193 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 936156002194 Bacterial SH3 domain; Region: SH3_3; cl17532 936156002195 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156002196 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 936156002197 active site 936156002198 metal binding site [ion binding]; metal-binding site 936156002199 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 936156002200 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 936156002201 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 936156002202 NAD binding site [chemical binding]; other site 936156002203 catalytic Zn binding site [ion binding]; other site 936156002204 structural Zn binding site [ion binding]; other site 936156002205 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 936156002206 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 936156002207 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 936156002208 DNA binding residues [nucleotide binding] 936156002209 putative dimer interface [polypeptide binding]; other site 936156002210 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 936156002211 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 936156002212 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 936156002213 putative NAD(P) binding site [chemical binding]; other site 936156002214 putative substrate binding site [chemical binding]; other site 936156002215 catalytic Zn binding site [ion binding]; other site 936156002216 structural Zn binding site [ion binding]; other site 936156002217 dimer interface [polypeptide binding]; other site 936156002218 intracellular protease, PfpI family; Region: PfpI; TIGR01382 936156002219 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 936156002220 proposed catalytic triad [active] 936156002221 conserved cys residue [active] 936156002222 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 936156002223 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 936156002224 substrate binding [chemical binding]; other site 936156002225 active site 936156002226 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 936156002227 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 936156002228 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 936156002229 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 936156002230 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 936156002231 active site 936156002232 phosphorylation site [posttranslational modification] 936156002233 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 936156002234 active pocket/dimerization site; other site 936156002235 active site 936156002236 phosphorylation site [posttranslational modification] 936156002237 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 936156002238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156002239 Walker A motif; other site 936156002240 ATP binding site [chemical binding]; other site 936156002241 Walker B motif; other site 936156002242 arginine finger; other site 936156002243 Transcriptional antiterminator [Transcription]; Region: COG3933 936156002244 PRD domain; Region: PRD; pfam00874 936156002245 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 936156002246 active pocket/dimerization site; other site 936156002247 active site 936156002248 phosphorylation site [posttranslational modification] 936156002249 PRD domain; Region: PRD; pfam00874 936156002250 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 936156002251 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 936156002252 Predicted transcriptional regulators [Transcription]; Region: COG1378 936156002253 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 936156002254 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 936156002255 C-terminal domain interface [polypeptide binding]; other site 936156002256 sugar binding site [chemical binding]; other site 936156002257 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 936156002258 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 936156002259 potential frameshift: common BLAST hit: gi|16079768|ref|NP_390592.1| peptidoglycan O-acetyltransferase 936156002260 YrhK-like protein; Region: YrhK; pfam14145 936156002261 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 936156002262 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 936156002263 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936156002264 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 936156002265 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 936156002266 metal binding site [ion binding]; metal-binding site 936156002267 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 936156002268 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 936156002269 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 936156002270 active sites [active] 936156002271 tetramer interface [polypeptide binding]; other site 936156002272 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 936156002273 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 936156002274 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936156002275 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 936156002276 acyl-activating enzyme (AAE) consensus motif; other site 936156002277 AMP binding site [chemical binding]; other site 936156002278 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 936156002279 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 936156002280 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 936156002281 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 936156002282 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 936156002283 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 936156002284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936156002285 Walker A/P-loop; other site 936156002286 ATP binding site [chemical binding]; other site 936156002287 Q-loop/lid; other site 936156002288 ABC transporter signature motif; other site 936156002289 Walker B; other site 936156002290 D-loop; other site 936156002291 H-loop/switch region; other site 936156002292 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 936156002293 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 936156002294 NAD binding site [chemical binding]; other site 936156002295 substrate binding site [chemical binding]; other site 936156002296 homodimer interface [polypeptide binding]; other site 936156002297 active site 936156002298 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 936156002299 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 936156002300 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 936156002301 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 936156002302 Cytochrome P450; Region: p450; pfam00067 936156002303 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 936156002304 Flavodoxin; Region: Flavodoxin_1; pfam00258 936156002305 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 936156002306 FAD binding pocket [chemical binding]; other site 936156002307 FAD binding motif [chemical binding]; other site 936156002308 catalytic residues [active] 936156002309 NAD binding pocket [chemical binding]; other site 936156002310 phosphate binding motif [ion binding]; other site 936156002311 beta-alpha-beta structure motif; other site 936156002312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156002313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156002314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156002315 S-adenosylmethionine binding site [chemical binding]; other site 936156002316 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 936156002317 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 936156002318 Uncharacterized conserved protein [Function unknown]; Region: COG5609 936156002319 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 936156002320 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 936156002321 catalytic loop [active] 936156002322 iron binding site [ion binding]; other site 936156002323 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 936156002324 4Fe-4S binding domain; Region: Fer4; pfam00037 936156002325 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 936156002326 [4Fe-4S] binding site [ion binding]; other site 936156002327 molybdopterin cofactor binding site; other site 936156002328 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 936156002329 molybdopterin cofactor binding site; other site 936156002330 Uncharacterized conserved protein [Function unknown]; Region: COG2427 936156002331 YrhC-like protein; Region: YrhC; pfam14143 936156002332 cystathionine beta-lyase; Provisional; Region: PRK07671 936156002333 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 936156002334 homodimer interface [polypeptide binding]; other site 936156002335 substrate-cofactor binding pocket; other site 936156002336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156002337 catalytic residue [active] 936156002338 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 936156002339 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 936156002340 dimer interface [polypeptide binding]; other site 936156002341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156002342 catalytic residue [active] 936156002343 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 936156002344 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 936156002345 Methyltransferase domain; Region: Methyltransf_23; pfam13489 936156002346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156002347 S-adenosylmethionine binding site [chemical binding]; other site 936156002348 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 936156002349 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 936156002350 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 936156002351 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 936156002352 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936156002353 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 936156002354 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 936156002355 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 936156002356 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 936156002357 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 936156002358 ATP-binding site [chemical binding]; other site 936156002359 Sugar specificity; other site 936156002360 Pyrimidine base specificity; other site 936156002361 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 936156002362 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 936156002363 Peptidase family U32; Region: Peptidase_U32; pfam01136 936156002364 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 936156002365 Peptidase family U32; Region: Peptidase_U32; pfam01136 936156002366 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 936156002367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156002368 S-adenosylmethionine binding site [chemical binding]; other site 936156002369 conserved hypothetical protein, YceG family; Region: TIGR00247 936156002370 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 936156002371 dimerization interface [polypeptide binding]; other site 936156002372 hypothetical protein; Provisional; Region: PRK13678 936156002373 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 936156002374 hypothetical protein; Provisional; Region: PRK05473 936156002375 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 936156002376 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 936156002377 motif 1; other site 936156002378 active site 936156002379 motif 2; other site 936156002380 motif 3; other site 936156002381 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 936156002382 DHHA1 domain; Region: DHHA1; pfam02272 936156002383 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 936156002384 Domain of unknown function DUF20; Region: UPF0118; pfam01594 936156002385 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 936156002386 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 936156002387 Walker A/P-loop; other site 936156002388 ATP binding site [chemical binding]; other site 936156002389 Q-loop/lid; other site 936156002390 ABC transporter signature motif; other site 936156002391 Walker B; other site 936156002392 D-loop; other site 936156002393 H-loop/switch region; other site 936156002394 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 936156002395 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936156002396 substrate binding pocket [chemical binding]; other site 936156002397 membrane-bound complex binding site; other site 936156002398 hinge residues; other site 936156002399 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 936156002400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156002401 dimer interface [polypeptide binding]; other site 936156002402 conserved gate region; other site 936156002403 putative PBP binding loops; other site 936156002404 ABC-ATPase subunit interface; other site 936156002405 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 936156002406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156002407 dimer interface [polypeptide binding]; other site 936156002408 ABC-ATPase subunit interface; other site 936156002409 putative PBP binding loops; other site 936156002410 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 936156002411 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 936156002412 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 936156002413 AAA domain; Region: AAA_30; pfam13604 936156002414 Family description; Region: UvrD_C_2; pfam13538 936156002415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156002416 binding surface 936156002417 TPR motif; other site 936156002418 TPR repeat; Region: TPR_11; pfam13414 936156002419 TPR repeat; Region: TPR_11; pfam13414 936156002420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156002421 binding surface 936156002422 TPR motif; other site 936156002423 TPR repeat; Region: TPR_11; pfam13414 936156002424 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 936156002425 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 936156002426 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 936156002427 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 936156002428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936156002429 catalytic residue [active] 936156002430 Predicted transcriptional regulator [Transcription]; Region: COG1959 936156002431 Transcriptional regulator; Region: Rrf2; pfam02082 936156002432 recombination factor protein RarA; Reviewed; Region: PRK13342 936156002433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156002434 Walker A motif; other site 936156002435 ATP binding site [chemical binding]; other site 936156002436 Walker B motif; other site 936156002437 arginine finger; other site 936156002438 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 936156002439 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 936156002440 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 936156002441 putative ATP binding site [chemical binding]; other site 936156002442 putative substrate interface [chemical binding]; other site 936156002443 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 936156002444 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 936156002445 dimer interface [polypeptide binding]; other site 936156002446 anticodon binding site; other site 936156002447 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 936156002448 homodimer interface [polypeptide binding]; other site 936156002449 motif 1; other site 936156002450 active site 936156002451 motif 2; other site 936156002452 GAD domain; Region: GAD; pfam02938 936156002453 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 936156002454 motif 3; other site 936156002455 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 936156002456 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 936156002457 dimer interface [polypeptide binding]; other site 936156002458 motif 1; other site 936156002459 active site 936156002460 motif 2; other site 936156002461 motif 3; other site 936156002462 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 936156002463 anticodon binding site; other site 936156002464 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 936156002465 Bacterial SH3 domain homologues; Region: SH3b; smart00287 936156002466 Bacterial SH3 domain; Region: SH3_3; pfam08239 936156002467 Bacterial SH3 domain; Region: SH3_3; pfam08239 936156002468 Bacterial SH3 domain homologues; Region: SH3b; smart00287 936156002469 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 936156002470 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 936156002471 active site 936156002472 metal binding site [ion binding]; metal-binding site 936156002473 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 936156002474 putative active site [active] 936156002475 dimerization interface [polypeptide binding]; other site 936156002476 putative tRNAtyr binding site [nucleotide binding]; other site 936156002477 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 936156002478 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936156002479 Zn2+ binding site [ion binding]; other site 936156002480 Mg2+ binding site [ion binding]; other site 936156002481 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 936156002482 synthetase active site [active] 936156002483 NTP binding site [chemical binding]; other site 936156002484 metal binding site [ion binding]; metal-binding site 936156002485 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 936156002486 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 936156002487 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936156002488 active site 936156002489 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 936156002490 DHH family; Region: DHH; pfam01368 936156002491 DHHA1 domain; Region: DHHA1; pfam02272 936156002492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 936156002493 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 936156002494 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 936156002495 TrkA-C domain; Region: TrkA_C; pfam02080 936156002496 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 936156002497 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 936156002498 Protein export membrane protein; Region: SecD_SecF; pfam02355 936156002499 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 936156002500 stage V sporulation protein B; Region: spore_V_B; TIGR02900 936156002501 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 936156002502 Predicted membrane protein [Function unknown]; Region: COG2323 936156002503 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 936156002504 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 936156002505 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 936156002506 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 936156002507 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 936156002508 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 936156002509 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 936156002510 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 936156002511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156002512 Walker A motif; other site 936156002513 ATP binding site [chemical binding]; other site 936156002514 Walker B motif; other site 936156002515 arginine finger; other site 936156002516 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 936156002517 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 936156002518 RuvA N terminal domain; Region: RuvA_N; pfam01330 936156002519 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 936156002520 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 936156002521 BofC C-terminal domain; Region: BofC_C; pfam08955 936156002522 polyol permease family; Region: 2A0118; TIGR00897 936156002523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156002524 putative substrate translocation pore; other site 936156002525 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 936156002526 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936156002527 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 936156002528 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 936156002529 active site 936156002530 substrate binding site [chemical binding]; other site 936156002531 ATP binding site [chemical binding]; other site 936156002532 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 936156002533 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 936156002534 hypothetical protein; Validated; Region: PRK00110 936156002535 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 936156002536 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156002537 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 936156002538 quinolinate synthetase complex, A subunit; Region: nadA; TIGR00550 936156002539 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 936156002540 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 936156002541 dimerization interface [polypeptide binding]; other site 936156002542 active site 936156002543 L-aspartate oxidase; Provisional; Region: PRK08071 936156002544 L-aspartate oxidase; Provisional; Region: PRK06175 936156002545 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 936156002546 cysteine desulfurase; Provisional; Region: PRK02948 936156002547 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 936156002548 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936156002549 catalytic residue [active] 936156002550 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 936156002551 HTH domain; Region: HTH_11; pfam08279 936156002552 3H domain; Region: 3H; pfam02829 936156002553 prephenate dehydratase; Provisional; Region: PRK11898 936156002554 Prephenate dehydratase; Region: PDT; pfam00800 936156002555 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 936156002556 putative L-Phe binding site [chemical binding]; other site 936156002557 hypothetical protein; Provisional; Region: PRK04435 936156002558 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 936156002559 GTPase CgtA; Reviewed; Region: obgE; PRK12297 936156002560 GTP1/OBG; Region: GTP1_OBG; pfam01018 936156002561 Obg GTPase; Region: Obg; cd01898 936156002562 G1 box; other site 936156002563 GTP/Mg2+ binding site [chemical binding]; other site 936156002564 Switch I region; other site 936156002565 G2 box; other site 936156002566 G3 box; other site 936156002567 Switch II region; other site 936156002568 G4 box; other site 936156002569 G5 box; other site 936156002570 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 936156002571 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 936156002572 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 936156002573 hypothetical protein; Provisional; Region: PRK14553 936156002574 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 936156002575 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 936156002576 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 936156002577 active site 936156002578 Peptidase family M50; Region: Peptidase_M50; pfam02163 936156002579 putative substrate binding region [chemical binding]; other site 936156002580 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 936156002581 Peptidase family M23; Region: Peptidase_M23; pfam01551 936156002582 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 936156002583 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 936156002584 Switch I; other site 936156002585 Switch II; other site 936156002586 septum formation inhibitor; Reviewed; Region: minC; PRK00513 936156002587 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 936156002588 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 936156002589 rod shape-determining protein MreC; Region: mreC; TIGR00219 936156002590 rod shape-determining protein MreC; Region: MreC; pfam04085 936156002591 rod shape-determining protein MreB; Provisional; Region: PRK13927 936156002592 MreB and similar proteins; Region: MreB_like; cd10225 936156002593 nucleotide binding site [chemical binding]; other site 936156002594 Mg binding site [ion binding]; other site 936156002595 putative protofilament interaction site [polypeptide binding]; other site 936156002596 RodZ interaction site [polypeptide binding]; other site 936156002597 hypothetical protein; Reviewed; Region: PRK00024 936156002598 Helix-hairpin-helix motif; Region: HHH; pfam00633 936156002599 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 936156002600 MPN+ (JAMM) motif; other site 936156002601 Zinc-binding site [ion binding]; other site 936156002602 Maf-like protein; Region: Maf; pfam02545 936156002603 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 936156002604 active site 936156002605 dimer interface [polypeptide binding]; other site 936156002606 Sporulation related domain; Region: SPOR; pfam05036 936156002607 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 936156002608 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 936156002609 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 936156002610 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936156002611 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936156002612 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 936156002613 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 936156002614 active site 936156002615 HIGH motif; other site 936156002616 nucleotide binding site [chemical binding]; other site 936156002617 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 936156002618 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 936156002619 active site 936156002620 KMSKS motif; other site 936156002621 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 936156002622 tRNA binding surface [nucleotide binding]; other site 936156002623 anticodon binding site; other site 936156002624 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 936156002625 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 936156002626 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 936156002627 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156002628 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 936156002629 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936156002630 inhibitor-cofactor binding pocket; inhibition site 936156002631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156002632 catalytic residue [active] 936156002633 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 936156002634 dimer interface [polypeptide binding]; other site 936156002635 active site 936156002636 Schiff base residues; other site 936156002637 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 936156002638 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 936156002639 active site 936156002640 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 936156002641 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 936156002642 domain interfaces; other site 936156002643 active site 936156002644 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 936156002645 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 936156002646 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 936156002647 tRNA; other site 936156002648 putative tRNA binding site [nucleotide binding]; other site 936156002649 putative NADP binding site [chemical binding]; other site 936156002650 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 936156002651 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 936156002652 G1 box; other site 936156002653 GTP/Mg2+ binding site [chemical binding]; other site 936156002654 Switch I region; other site 936156002655 G2 box; other site 936156002656 G3 box; other site 936156002657 Switch II region; other site 936156002658 G4 box; other site 936156002659 G5 box; other site 936156002660 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 936156002661 Found in ATP-dependent protease La (LON); Region: LON; smart00464 936156002662 Found in ATP-dependent protease La (LON); Region: LON; smart00464 936156002663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156002664 Walker A motif; other site 936156002665 ATP binding site [chemical binding]; other site 936156002666 Walker B motif; other site 936156002667 arginine finger; other site 936156002668 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 936156002669 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 936156002670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156002671 Walker A motif; other site 936156002672 ATP binding site [chemical binding]; other site 936156002673 Walker B motif; other site 936156002674 arginine finger; other site 936156002675 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 936156002676 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 936156002677 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 936156002678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156002679 Walker A motif; other site 936156002680 ATP binding site [chemical binding]; other site 936156002681 Walker B motif; other site 936156002682 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 936156002683 trigger factor; Provisional; Region: tig; PRK01490 936156002684 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 936156002685 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 936156002686 TPR repeat; Region: TPR_11; pfam13414 936156002687 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156002688 binding surface 936156002689 TPR motif; other site 936156002690 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 936156002691 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 936156002692 substrate binding site [chemical binding]; other site 936156002693 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 936156002694 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 936156002695 substrate binding site [chemical binding]; other site 936156002696 ligand binding site [chemical binding]; other site 936156002697 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 936156002698 tartrate dehydrogenase; Region: TTC; TIGR02089 936156002699 2-isopropylmalate synthase; Validated; Region: PRK00915 936156002700 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 936156002701 active site 936156002702 catalytic residues [active] 936156002703 metal binding site [ion binding]; metal-binding site 936156002704 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 936156002705 ketol-acid reductoisomerase; Provisional; Region: PRK05479 936156002706 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 936156002707 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 936156002708 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 936156002709 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 936156002710 putative valine binding site [chemical binding]; other site 936156002711 dimer interface [polypeptide binding]; other site 936156002712 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 936156002713 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 936156002714 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 936156002715 PYR/PP interface [polypeptide binding]; other site 936156002716 dimer interface [polypeptide binding]; other site 936156002717 TPP binding site [chemical binding]; other site 936156002718 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 936156002719 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 936156002720 TPP-binding site [chemical binding]; other site 936156002721 dimer interface [polypeptide binding]; other site 936156002722 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 936156002723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156002724 Coenzyme A binding pocket [chemical binding]; other site 936156002725 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 936156002726 Heat induced stress protein YflT; Region: YflT; pfam11181 936156002727 conserved domain; Region: TIGR02271 936156002728 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 936156002729 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 936156002730 active site 936156002731 metal binding site [ion binding]; metal-binding site 936156002732 homotetramer interface [polypeptide binding]; other site 936156002733 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 936156002734 active site 936156002735 dimerization interface [polypeptide binding]; other site 936156002736 ribonuclease PH; Reviewed; Region: rph; PRK00173 936156002737 Ribonuclease PH; Region: RNase_PH_bact; cd11362 936156002738 hexamer interface [polypeptide binding]; other site 936156002739 active site 936156002740 Spore germination protein [General function prediction only]; Region: COG5401 936156002741 Sporulation and spore germination; Region: Germane; pfam10646 936156002742 Sporulation and spore germination; Region: Germane; pfam10646 936156002743 glutamate racemase; Region: glut_race; TIGR00067 936156002744 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156002745 MarR family; Region: MarR; pfam01047 936156002746 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936156002747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936156002748 DNA binding residues [nucleotide binding] 936156002749 dimerization interface [polypeptide binding]; other site 936156002750 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 936156002751 active site 936156002752 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 936156002753 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 936156002754 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 936156002755 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 936156002756 L-aspartate oxidase; Provisional; Region: PRK06175 936156002757 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 936156002758 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 936156002759 putative Iron-sulfur protein interface [polypeptide binding]; other site 936156002760 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 936156002761 proximal heme binding site [chemical binding]; other site 936156002762 distal heme binding site [chemical binding]; other site 936156002763 putative dimer interface [polypeptide binding]; other site 936156002764 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 936156002765 aspartate kinase; Reviewed; Region: PRK06635 936156002766 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 936156002767 putative nucleotide binding site [chemical binding]; other site 936156002768 putative catalytic residues [active] 936156002769 putative Mg ion binding site [ion binding]; other site 936156002770 putative aspartate binding site [chemical binding]; other site 936156002771 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 936156002772 putative allosteric regulatory site; other site 936156002773 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 936156002774 putative allosteric regulatory residue; other site 936156002775 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 936156002776 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 936156002777 GIY-YIG motif/motif A; other site 936156002778 active site 936156002779 catalytic site [active] 936156002780 putative DNA binding site [nucleotide binding]; other site 936156002781 metal binding site [ion binding]; metal-binding site 936156002782 UvrB/uvrC motif; Region: UVR; pfam02151 936156002783 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 936156002784 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 936156002785 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 936156002786 catalytic residues [active] 936156002787 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 936156002788 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 936156002789 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 936156002790 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 936156002791 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 936156002792 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 936156002793 Ligand binding site [chemical binding]; other site 936156002794 Electron transfer flavoprotein domain; Region: ETF; pfam01012 936156002795 enoyl-CoA hydratase; Provisional; Region: PRK07658 936156002796 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 936156002797 substrate binding site [chemical binding]; other site 936156002798 oxyanion hole (OAH) forming residues; other site 936156002799 trimer interface [polypeptide binding]; other site 936156002800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156002801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156002802 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 936156002803 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 936156002804 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 936156002805 acyl-activating enzyme (AAE) consensus motif; other site 936156002806 putative AMP binding site [chemical binding]; other site 936156002807 putative active site [active] 936156002808 putative CoA binding site [chemical binding]; other site 936156002809 Predicted membrane protein [Function unknown]; Region: COG3766 936156002810 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 936156002811 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 936156002812 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 936156002813 MutS domain III; Region: MutS_III; pfam05192 936156002814 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 936156002815 Walker A/P-loop; other site 936156002816 ATP binding site [chemical binding]; other site 936156002817 Q-loop/lid; other site 936156002818 ABC transporter signature motif; other site 936156002819 Walker B; other site 936156002820 D-loop; other site 936156002821 H-loop/switch region; other site 936156002822 Smr domain; Region: Smr; pfam01713 936156002823 hypothetical protein; Provisional; Region: PRK08609 936156002824 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 936156002825 active site 936156002826 primer binding site [nucleotide binding]; other site 936156002827 NTP binding site [chemical binding]; other site 936156002828 metal binding triad [ion binding]; metal-binding site 936156002829 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 936156002830 active site 936156002831 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 936156002832 Colicin V production protein; Region: Colicin_V; pfam02674 936156002833 cell division protein ZapA; Provisional; Region: PRK14126 936156002834 ribonuclease HIII; Provisional; Region: PRK00996 936156002835 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 936156002836 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 936156002837 RNA/DNA hybrid binding site [nucleotide binding]; other site 936156002838 active site 936156002839 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 936156002840 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 936156002841 putative tRNA-binding site [nucleotide binding]; other site 936156002842 B3/4 domain; Region: B3_4; pfam03483 936156002843 tRNA synthetase B5 domain; Region: B5; smart00874 936156002844 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 936156002845 dimer interface [polypeptide binding]; other site 936156002846 motif 1; other site 936156002847 motif 3; other site 936156002848 motif 2; other site 936156002849 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 936156002850 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 936156002851 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 936156002852 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 936156002853 dimer interface [polypeptide binding]; other site 936156002854 motif 1; other site 936156002855 active site 936156002856 motif 2; other site 936156002857 motif 3; other site 936156002858 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 936156002859 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 936156002860 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 936156002861 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 936156002862 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 936156002863 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 936156002864 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 936156002865 FAD binding domain; Region: FAD_binding_4; pfam01565 936156002866 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 936156002867 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 936156002868 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 936156002869 Cysteine-rich domain; Region: CCG; pfam02754 936156002870 Cysteine-rich domain; Region: CCG; pfam02754 936156002871 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 936156002872 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156002873 active site 936156002874 metal binding site [ion binding]; metal-binding site 936156002875 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 936156002876 Carbon starvation protein CstA; Region: CstA; pfam02554 936156002877 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 936156002878 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 936156002879 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 936156002880 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 936156002881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156002882 putative PBP binding loops; other site 936156002883 dimer interface [polypeptide binding]; other site 936156002884 ABC-ATPase subunit interface; other site 936156002885 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 936156002886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156002887 dimer interface [polypeptide binding]; other site 936156002888 conserved gate region; other site 936156002889 putative PBP binding loops; other site 936156002890 ABC-ATPase subunit interface; other site 936156002891 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 936156002892 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 936156002893 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 936156002894 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 936156002895 active site 936156002896 metal binding site [ion binding]; metal-binding site 936156002897 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 936156002898 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156002899 active site 936156002900 motif I; other site 936156002901 motif II; other site 936156002902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156002903 motif II; other site 936156002904 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 936156002905 L-ribulose-5-phosphate 4-epimerase; Region: araD; TIGR00760 936156002906 intersubunit interface [polypeptide binding]; other site 936156002907 active site 936156002908 Zn2+ binding site [ion binding]; other site 936156002909 L-ribulokinase; Region: L-ribulokinase; TIGR01234 936156002910 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 936156002911 N- and C-terminal domain interface [polypeptide binding]; other site 936156002912 active site 936156002913 MgATP binding site [chemical binding]; other site 936156002914 catalytic site [active] 936156002915 metal binding site [ion binding]; metal-binding site 936156002916 carbohydrate binding site [chemical binding]; other site 936156002917 homodimer interface [polypeptide binding]; other site 936156002918 L-arabinose isomerase; Provisional; Region: PRK02929 936156002919 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 936156002920 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 936156002921 trimer interface [polypeptide binding]; other site 936156002922 putative substrate binding site [chemical binding]; other site 936156002923 putative metal binding site [ion binding]; other site 936156002924 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 936156002925 substrate binding site [chemical binding]; other site 936156002926 active site 936156002927 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 936156002928 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 936156002929 oligomer interface [polypeptide binding]; other site 936156002930 active site 936156002931 metal binding site [ion binding]; metal-binding site 936156002932 Predicted membrane protein [Function unknown]; Region: COG3326 936156002933 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 936156002934 23S rRNA binding site [nucleotide binding]; other site 936156002935 L21 binding site [polypeptide binding]; other site 936156002936 L13 binding site [polypeptide binding]; other site 936156002937 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 936156002938 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 936156002939 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 936156002940 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 936156002941 antiholin-like protein LrgB; Provisional; Region: PRK04288 936156002942 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 936156002943 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 936156002944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156002945 active site 936156002946 phosphorylation site [posttranslational modification] 936156002947 intermolecular recognition site; other site 936156002948 dimerization interface [polypeptide binding]; other site 936156002949 LytTr DNA-binding domain; Region: LytTR; pfam04397 936156002950 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 936156002951 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 936156002952 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 936156002953 Histidine kinase; Region: His_kinase; pfam06580 936156002954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156002955 ATP binding site [chemical binding]; other site 936156002956 Mg2+ binding site [ion binding]; other site 936156002957 G-X-G motif; other site 936156002958 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 936156002959 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156002960 motif II; other site 936156002961 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 936156002962 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 936156002963 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 936156002964 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 936156002965 active site 936156002966 dimer interface [polypeptide binding]; other site 936156002967 motif 1; other site 936156002968 motif 2; other site 936156002969 motif 3; other site 936156002970 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 936156002971 anticodon binding site; other site 936156002972 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 936156002973 Uncharacterized conserved protein [Function unknown]; Region: COG0398 936156002974 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 936156002975 primosomal protein DnaI; Reviewed; Region: PRK08939 936156002976 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 936156002977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156002978 Walker A motif; other site 936156002979 ATP binding site [chemical binding]; other site 936156002980 Walker B motif; other site 936156002981 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 936156002982 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 936156002983 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 936156002984 ATP cone domain; Region: ATP-cone; pfam03477 936156002985 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 936156002986 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 936156002987 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 936156002988 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 936156002989 Predicted transcriptional regulators [Transcription]; Region: COG1733 936156002990 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 936156002991 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936156002992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156002993 putative substrate translocation pore; other site 936156002994 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936156002995 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936156002996 active site 936156002997 catalytic tetrad [active] 936156002998 dephospho-CoA kinase; Region: TIGR00152 936156002999 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 936156003000 CoA-binding site [chemical binding]; other site 936156003001 ATP-binding [chemical binding]; other site 936156003002 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 936156003003 Domain of unknown function DUF; Region: DUF204; pfam02659 936156003004 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 936156003005 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 936156003006 DNA binding site [nucleotide binding] 936156003007 catalytic residue [active] 936156003008 H2TH interface [polypeptide binding]; other site 936156003009 putative catalytic residues [active] 936156003010 turnover-facilitating residue; other site 936156003011 intercalation triad [nucleotide binding]; other site 936156003012 8OG recognition residue [nucleotide binding]; other site 936156003013 putative reading head residues; other site 936156003014 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 936156003015 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 936156003016 DNA polymerase I; Provisional; Region: PRK05755 936156003017 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 936156003018 active site 936156003019 metal binding site 1 [ion binding]; metal-binding site 936156003020 putative 5' ssDNA interaction site; other site 936156003021 metal binding site 3; metal-binding site 936156003022 metal binding site 2 [ion binding]; metal-binding site 936156003023 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 936156003024 putative DNA binding site [nucleotide binding]; other site 936156003025 putative metal binding site [ion binding]; other site 936156003026 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 936156003027 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 936156003028 active site 936156003029 DNA binding site [nucleotide binding] 936156003030 catalytic site [active] 936156003031 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 936156003032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156003033 putative active site [active] 936156003034 heme pocket [chemical binding]; other site 936156003035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156003036 dimer interface [polypeptide binding]; other site 936156003037 phosphorylation site [posttranslational modification] 936156003038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156003039 ATP binding site [chemical binding]; other site 936156003040 Mg2+ binding site [ion binding]; other site 936156003041 G-X-G motif; other site 936156003042 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936156003043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156003044 active site 936156003045 phosphorylation site [posttranslational modification] 936156003046 intermolecular recognition site; other site 936156003047 dimerization interface [polypeptide binding]; other site 936156003048 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936156003049 DNA binding site [nucleotide binding] 936156003050 malate dehydrogenase; Reviewed; Region: PRK06223 936156003051 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 936156003052 NAD(P) binding site [chemical binding]; other site 936156003053 dimer interface [polypeptide binding]; other site 936156003054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 936156003055 substrate binding site [chemical binding]; other site 936156003056 isocitrate dehydrogenase; Reviewed; Region: PRK07006 936156003057 isocitrate dehydrogenase; Validated; Region: PRK07362 936156003058 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 936156003059 dimer interface [polypeptide binding]; other site 936156003060 Citrate synthase; Region: Citrate_synt; pfam00285 936156003061 active site 936156003062 citrylCoA binding site [chemical binding]; other site 936156003063 oxalacetate/citrate binding site [chemical binding]; other site 936156003064 coenzyme A binding site [chemical binding]; other site 936156003065 catalytic triad [active] 936156003066 Predicted membrane protein [Function unknown]; Region: COG2707 936156003067 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 936156003068 Domain of unknown function DUF20; Region: UPF0118; pfam01594 936156003069 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 936156003070 pyruvate kinase; Provisional; Region: PRK06354 936156003071 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 936156003072 domain interfaces; other site 936156003073 active site 936156003074 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 936156003075 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 936156003076 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 936156003077 active site 936156003078 ADP/pyrophosphate binding site [chemical binding]; other site 936156003079 dimerization interface [polypeptide binding]; other site 936156003080 allosteric effector site; other site 936156003081 fructose-1,6-bisphosphate binding site; other site 936156003082 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 936156003083 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 936156003084 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 936156003085 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 936156003086 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 936156003087 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 936156003088 Malic enzyme, N-terminal domain; Region: malic; pfam00390 936156003089 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 936156003090 putative NAD(P) binding site [chemical binding]; other site 936156003091 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 936156003092 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 936156003093 active site 936156003094 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 936156003095 generic binding surface I; other site 936156003096 generic binding surface II; other site 936156003097 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 936156003098 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 936156003099 DHH family; Region: DHH; pfam01368 936156003100 DHHA1 domain; Region: DHHA1; pfam02272 936156003101 YtpI-like protein; Region: YtpI; pfam14007 936156003102 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 936156003103 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156003104 DNA-binding site [nucleotide binding]; DNA binding site 936156003105 DRTGG domain; Region: DRTGG; pfam07085 936156003106 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 936156003107 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 936156003108 active site 2 [active] 936156003109 active site 1 [active] 936156003110 Predicted permeases [General function prediction only]; Region: COG0730 936156003111 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 936156003112 amidohydrolase; Region: amidohydrolases; TIGR01891 936156003113 metal binding site [ion binding]; metal-binding site 936156003114 dimer interface [polypeptide binding]; other site 936156003115 Riboflavin kinase; Region: Flavokinase; pfam01687 936156003116 Riboflavin kinase; Region: Flavokinase; cl03312 936156003117 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 936156003118 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 936156003119 active site 936156003120 non-prolyl cis peptide bond; other site 936156003121 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 936156003122 catalytic residues [active] 936156003123 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 936156003124 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 936156003125 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 936156003126 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 936156003127 Walker A/P-loop; other site 936156003128 ATP binding site [chemical binding]; other site 936156003129 Q-loop/lid; other site 936156003130 ABC transporter signature motif; other site 936156003131 Walker B; other site 936156003132 D-loop; other site 936156003133 H-loop/switch region; other site 936156003134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156003135 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 936156003136 dimer interface [polypeptide binding]; other site 936156003137 conserved gate region; other site 936156003138 putative PBP binding loops; other site 936156003139 ABC-ATPase subunit interface; other site 936156003140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156003141 dimer interface [polypeptide binding]; other site 936156003142 conserved gate region; other site 936156003143 putative PBP binding loops; other site 936156003144 ABC-ATPase subunit interface; other site 936156003145 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 936156003146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936156003147 substrate binding pocket [chemical binding]; other site 936156003148 membrane-bound complex binding site; other site 936156003149 hinge residues; other site 936156003150 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 936156003151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936156003152 substrate binding pocket [chemical binding]; other site 936156003153 membrane-bound complex binding site; other site 936156003154 hinge residues; other site 936156003155 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 936156003156 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156003157 Coenzyme A binding pocket [chemical binding]; other site 936156003158 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156003159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156003160 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936156003161 dimerization interface [polypeptide binding]; other site 936156003162 metal-dependent hydrolase; Provisional; Region: PRK00685 936156003163 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 936156003164 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 936156003165 classical (c) SDRs; Region: SDR_c; cd05233 936156003166 NAD(P) binding site [chemical binding]; other site 936156003167 active site 936156003168 argininosuccinate lyase; Provisional; Region: PRK00855 936156003169 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 936156003170 active sites [active] 936156003171 tetramer interface [polypeptide binding]; other site 936156003172 argininosuccinate synthase; Provisional; Region: PRK13820 936156003173 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 936156003174 ANP binding site [chemical binding]; other site 936156003175 Substrate Binding Site II [chemical binding]; other site 936156003176 Substrate Binding Site I [chemical binding]; other site 936156003177 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 936156003178 MPT binding site; other site 936156003179 trimer interface [polypeptide binding]; other site 936156003180 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 936156003181 propionate/acetate kinase; Provisional; Region: PRK12379 936156003182 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 936156003183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156003184 S-adenosylmethionine binding site [chemical binding]; other site 936156003185 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 936156003186 dimer interface [polypeptide binding]; other site 936156003187 catalytic triad [active] 936156003188 peroxidatic and resolving cysteines [active] 936156003189 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 936156003190 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 936156003191 Predicted membrane protein/domain [Function unknown]; Region: COG1714 936156003192 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 936156003193 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 936156003194 tandem repeat interface [polypeptide binding]; other site 936156003195 oligomer interface [polypeptide binding]; other site 936156003196 active site residues [active] 936156003197 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 936156003198 ATP-NAD kinase; Region: NAD_kinase; pfam01513 936156003199 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 936156003200 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 936156003201 active site 936156003202 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 936156003203 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 936156003204 active site 936156003205 acyl-activating enzyme (AAE) consensus motif; other site 936156003206 putative CoA binding site [chemical binding]; other site 936156003207 AMP binding site [chemical binding]; other site 936156003208 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 936156003209 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 936156003210 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 936156003211 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 936156003212 Ligand Binding Site [chemical binding]; other site 936156003213 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 936156003214 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 936156003215 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936156003216 catalytic residue [active] 936156003217 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 936156003218 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 936156003219 histidinol-phosphatase; Reviewed; Region: PRK08123 936156003220 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 936156003221 active site 936156003222 dimer interface [polypeptide binding]; other site 936156003223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156003224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156003225 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 936156003226 GAF domain; Region: GAF_2; pfam13185 936156003227 GAF domain; Region: GAF; cl17456 936156003228 GAF domain; Region: GAF_3; pfam13492 936156003229 GAF domain; Region: GAF_2; pfam13185 936156003230 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 936156003231 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936156003232 metal binding site [ion binding]; metal-binding site 936156003233 active site 936156003234 I-site; other site 936156003235 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 936156003236 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 936156003237 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936156003238 RNA binding surface [nucleotide binding]; other site 936156003239 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 936156003240 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 936156003241 active site 936156003242 HIGH motif; other site 936156003243 dimer interface [polypeptide binding]; other site 936156003244 KMSKS motif; other site 936156003245 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936156003246 RNA binding surface [nucleotide binding]; other site 936156003247 acetyl-CoA synthetase; Provisional; Region: PRK04319 936156003248 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 936156003249 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 936156003250 active site 936156003251 acyl-activating enzyme (AAE) consensus motif; other site 936156003252 putative CoA binding site [chemical binding]; other site 936156003253 AMP binding site [chemical binding]; other site 936156003254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156003255 Coenzyme A binding pocket [chemical binding]; other site 936156003256 FOG: CBS domain [General function prediction only]; Region: COG0517 936156003257 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 936156003258 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 936156003259 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 936156003260 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 936156003261 active site 936156003262 Zn binding site [ion binding]; other site 936156003263 flagellar motor protein MotS; Reviewed; Region: PRK06925 936156003264 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 936156003265 ligand binding site [chemical binding]; other site 936156003266 flagellar motor protein MotP; Reviewed; Region: PRK06926 936156003267 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 936156003268 catabolite control protein A; Region: ccpA; TIGR01481 936156003269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936156003270 DNA binding site [nucleotide binding] 936156003271 domain linker motif; other site 936156003272 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 936156003273 dimerization interface [polypeptide binding]; other site 936156003274 effector binding site; other site 936156003275 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 936156003276 chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801 936156003277 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 936156003278 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 936156003279 catalytic residues [active] 936156003280 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 936156003281 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 936156003282 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 936156003283 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 936156003284 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936156003285 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936156003286 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 936156003287 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 936156003288 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 936156003289 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 936156003290 putative tRNA-binding site [nucleotide binding]; other site 936156003291 hypothetical protein; Provisional; Region: PRK13668 936156003292 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 936156003293 catalytic residues [active] 936156003294 YtoQ family protein; Region: YtoQ_fam; TIGR03646 936156003295 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 936156003296 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 936156003297 oligomer interface [polypeptide binding]; other site 936156003298 active site 936156003299 metal binding site [ion binding]; metal-binding site 936156003300 Predicted small secreted protein [Function unknown]; Region: COG5584 936156003301 malate dehydrogenase; Provisional; Region: PRK13529 936156003302 Malic enzyme, N-terminal domain; Region: malic; pfam00390 936156003303 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 936156003304 NAD(P) binding site [chemical binding]; other site 936156003305 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 936156003306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156003307 S-adenosylmethionine binding site [chemical binding]; other site 936156003308 YtzH-like protein; Region: YtzH; pfam14165 936156003309 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 936156003310 active site 936156003311 ATP binding site [chemical binding]; other site 936156003312 Phosphotransferase enzyme family; Region: APH; pfam01636 936156003313 substrate binding site [chemical binding]; other site 936156003314 pullulanase, type I; Region: pulA_typeI; TIGR02104 936156003315 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 936156003316 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 936156003317 Ca binding site [ion binding]; other site 936156003318 active site 936156003319 catalytic site [active] 936156003320 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 936156003321 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 936156003322 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 936156003323 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 936156003324 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 936156003325 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 936156003326 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 936156003327 dimer interface [polypeptide binding]; other site 936156003328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156003329 catalytic residue [active] 936156003330 dipeptidase PepV; Reviewed; Region: PRK07318 936156003331 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 936156003332 active site 936156003333 metal binding site [ion binding]; metal-binding site 936156003334 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 936156003335 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 936156003336 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 936156003337 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 936156003338 Walker A/P-loop; other site 936156003339 ATP binding site [chemical binding]; other site 936156003340 Q-loop/lid; other site 936156003341 ABC transporter signature motif; other site 936156003342 Walker B; other site 936156003343 D-loop; other site 936156003344 H-loop/switch region; other site 936156003345 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936156003346 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 936156003347 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 936156003348 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936156003349 RNA binding surface [nucleotide binding]; other site 936156003350 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 936156003351 active site 936156003352 uracil binding [chemical binding]; other site 936156003353 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 936156003354 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 936156003355 Predicted flavoproteins [General function prediction only]; Region: COG2081 936156003356 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936156003357 BCCT family transporter; Region: BCCT; pfam02028 936156003358 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 936156003359 Predicted integral membrane protein [Function unknown]; Region: COG5578 936156003360 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 936156003361 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936156003362 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 936156003363 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 936156003364 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 936156003365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156003366 dimer interface [polypeptide binding]; other site 936156003367 conserved gate region; other site 936156003368 ABC-ATPase subunit interface; other site 936156003369 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156003370 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936156003371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156003372 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 936156003373 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 936156003374 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 936156003375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156003376 dimer interface [polypeptide binding]; other site 936156003377 conserved gate region; other site 936156003378 putative PBP binding loops; other site 936156003379 ABC-ATPase subunit interface; other site 936156003380 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 936156003381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 936156003382 NAD(P) binding site [chemical binding]; other site 936156003383 active site 936156003384 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 936156003385 Cytochrome P450; Region: p450; cl12078 936156003386 biotin synthase; Validated; Region: PRK06256 936156003387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936156003388 FeS/SAM binding site; other site 936156003389 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 936156003390 AAA domain; Region: AAA_26; pfam13500 936156003391 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 936156003392 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 936156003393 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 936156003394 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 936156003395 substrate-cofactor binding pocket; other site 936156003396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156003397 catalytic residue [active] 936156003398 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 936156003399 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936156003400 inhibitor-cofactor binding pocket; inhibition site 936156003401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156003402 catalytic residue [active] 936156003403 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 936156003404 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 936156003405 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 936156003406 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936156003407 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936156003408 DNA binding site [nucleotide binding] 936156003409 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 936156003410 putative ligand binding site [chemical binding]; other site 936156003411 putative dimerization interface [polypeptide binding]; other site 936156003412 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 936156003413 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 936156003414 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 936156003415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156003416 dimer interface [polypeptide binding]; other site 936156003417 conserved gate region; other site 936156003418 putative PBP binding loops; other site 936156003419 ABC-ATPase subunit interface; other site 936156003420 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 936156003421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156003422 dimer interface [polypeptide binding]; other site 936156003423 conserved gate region; other site 936156003424 putative PBP binding loops; other site 936156003425 ABC-ATPase subunit interface; other site 936156003426 alpha-galactosidase; Provisional; Region: PRK15076 936156003427 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 936156003428 NAD binding site [chemical binding]; other site 936156003429 sugar binding site [chemical binding]; other site 936156003430 divalent metal binding site [ion binding]; other site 936156003431 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 936156003432 dimer interface [polypeptide binding]; other site 936156003433 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 936156003434 active site residue [active] 936156003435 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 936156003436 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 936156003437 HIGH motif; other site 936156003438 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 936156003439 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 936156003440 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 936156003441 active site 936156003442 KMSKS motif; other site 936156003443 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 936156003444 tRNA binding surface [nucleotide binding]; other site 936156003445 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 936156003446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156003447 PAS domain; Region: PAS_9; pfam13426 936156003448 putative active site [active] 936156003449 heme pocket [chemical binding]; other site 936156003450 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 936156003451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156003452 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156003453 putative substrate translocation pore; other site 936156003454 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 936156003455 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 936156003456 FtsX-like permease family; Region: FtsX; pfam02687 936156003457 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 936156003458 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 936156003459 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 936156003460 Walker A/P-loop; other site 936156003461 ATP binding site [chemical binding]; other site 936156003462 Q-loop/lid; other site 936156003463 ABC transporter signature motif; other site 936156003464 Walker B; other site 936156003465 D-loop; other site 936156003466 H-loop/switch region; other site 936156003467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936156003468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156003469 ATP binding site [chemical binding]; other site 936156003470 Mg2+ binding site [ion binding]; other site 936156003471 G-X-G motif; other site 936156003472 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936156003473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156003474 active site 936156003475 phosphorylation site [posttranslational modification] 936156003476 intermolecular recognition site; other site 936156003477 dimerization interface [polypeptide binding]; other site 936156003478 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936156003479 DNA binding site [nucleotide binding] 936156003480 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 936156003481 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 936156003482 FtsX-like permease family; Region: FtsX; pfam02687 936156003483 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 936156003484 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 936156003485 Walker A/P-loop; other site 936156003486 ATP binding site [chemical binding]; other site 936156003487 Q-loop/lid; other site 936156003488 ABC transporter signature motif; other site 936156003489 Walker B; other site 936156003490 D-loop; other site 936156003491 H-loop/switch region; other site 936156003492 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 936156003493 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 936156003494 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 936156003495 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 936156003496 Walker A/P-loop; other site 936156003497 ATP binding site [chemical binding]; other site 936156003498 Q-loop/lid; other site 936156003499 ABC transporter signature motif; other site 936156003500 Walker B; other site 936156003501 D-loop; other site 936156003502 H-loop/switch region; other site 936156003503 Predicted transcriptional regulators [Transcription]; Region: COG1725 936156003504 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156003505 DNA-binding site [nucleotide binding]; DNA binding site 936156003506 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 936156003507 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 936156003508 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 936156003509 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 936156003510 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 936156003511 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 936156003512 PGAP1-like protein; Region: PGAP1; pfam07819 936156003513 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 936156003514 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 936156003515 trimer interface [polypeptide binding]; other site 936156003516 putative metal binding site [ion binding]; other site 936156003517 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 936156003518 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 936156003519 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 936156003520 active site 936156003521 dimer interface [polypeptide binding]; other site 936156003522 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 936156003523 Ligand Binding Site [chemical binding]; other site 936156003524 Molecular Tunnel; other site 936156003525 S-adenosylmethionine synthetase; Validated; Region: PRK05250 936156003526 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 936156003527 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 936156003528 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 936156003529 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 936156003530 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 936156003531 active site 936156003532 substrate-binding site [chemical binding]; other site 936156003533 metal-binding site [ion binding] 936156003534 ATP binding site [chemical binding]; other site 936156003535 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 936156003536 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 936156003537 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 936156003538 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 936156003539 NMT1-like family; Region: NMT1_2; pfam13379 936156003540 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 936156003541 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 936156003542 Walker A/P-loop; other site 936156003543 ATP binding site [chemical binding]; other site 936156003544 Q-loop/lid; other site 936156003545 ABC transporter signature motif; other site 936156003546 Walker B; other site 936156003547 D-loop; other site 936156003548 H-loop/switch region; other site 936156003549 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 936156003550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156003551 dimer interface [polypeptide binding]; other site 936156003552 conserved gate region; other site 936156003553 putative PBP binding loops; other site 936156003554 ABC-ATPase subunit interface; other site 936156003555 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 936156003556 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 936156003557 nudix motif; other site 936156003558 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 936156003559 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 936156003560 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 936156003561 dimerization interface [polypeptide binding]; other site 936156003562 DPS ferroxidase diiron center [ion binding]; other site 936156003563 ion pore; other site 936156003564 YtkA-like; Region: YtkA; pfam13115 936156003565 S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664 936156003566 Haemolytic domain; Region: Haemolytic; pfam01809 936156003567 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 936156003568 active site clefts [active] 936156003569 zinc binding site [ion binding]; other site 936156003570 dimer interface [polypeptide binding]; other site 936156003571 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 936156003572 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 936156003573 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 936156003574 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 936156003575 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 936156003576 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156003577 ABC-ATPase subunit interface; other site 936156003578 dimer interface [polypeptide binding]; other site 936156003579 putative PBP binding regions; other site 936156003580 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 936156003581 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156003582 ABC-ATPase subunit interface; other site 936156003583 dimer interface [polypeptide binding]; other site 936156003584 putative PBP binding regions; other site 936156003585 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 936156003586 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 936156003587 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 936156003588 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 936156003589 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 936156003590 metal binding site [ion binding]; metal-binding site 936156003591 intersubunit interface [polypeptide binding]; other site 936156003592 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 936156003593 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 936156003594 active site 936156003595 octamer interface [polypeptide binding]; other site 936156003596 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 936156003597 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 936156003598 acyl-activating enzyme (AAE) consensus motif; other site 936156003599 putative AMP binding site [chemical binding]; other site 936156003600 putative active site [active] 936156003601 putative CoA binding site [chemical binding]; other site 936156003602 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 936156003603 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 936156003604 substrate binding site [chemical binding]; other site 936156003605 oxyanion hole (OAH) forming residues; other site 936156003606 trimer interface [polypeptide binding]; other site 936156003607 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 936156003608 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 936156003609 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 936156003610 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 936156003611 dimer interface [polypeptide binding]; other site 936156003612 tetramer interface [polypeptide binding]; other site 936156003613 PYR/PP interface [polypeptide binding]; other site 936156003614 TPP binding site [chemical binding]; other site 936156003615 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 936156003616 TPP-binding site; other site 936156003617 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 936156003618 chorismate binding enzyme; Region: Chorismate_bind; cl10555 936156003619 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 936156003620 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 936156003621 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 936156003622 active site 936156003623 tetramer interface; other site 936156003624 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 936156003625 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 936156003626 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 936156003627 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 936156003628 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 936156003629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 936156003630 NAD(P) binding site [chemical binding]; other site 936156003631 active site 936156003632 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936156003633 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 936156003634 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 936156003635 spore coat protein YutH; Region: spore_yutH; TIGR02905 936156003636 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936156003637 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 936156003638 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 936156003639 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 936156003640 TspO/MBR family; Region: TspO_MBR; cl01379 936156003641 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 936156003642 homodimer interface [polypeptide binding]; other site 936156003643 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 936156003644 active site pocket [active] 936156003645 glycogen synthase; Provisional; Region: glgA; PRK00654 936156003646 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 936156003647 ADP-binding pocket [chemical binding]; other site 936156003648 homodimer interface [polypeptide binding]; other site 936156003649 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 936156003650 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 936156003651 ligand binding site; other site 936156003652 oligomer interface; other site 936156003653 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 936156003654 dimer interface [polypeptide binding]; other site 936156003655 N-terminal domain interface [polypeptide binding]; other site 936156003656 sulfate 1 binding site; other site 936156003657 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 936156003658 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 936156003659 ligand binding site; other site 936156003660 oligomer interface; other site 936156003661 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 936156003662 dimer interface [polypeptide binding]; other site 936156003663 N-terminal domain interface [polypeptide binding]; other site 936156003664 sulfate 1 binding site; other site 936156003665 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 936156003666 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 936156003667 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 936156003668 active site 936156003669 catalytic site [active] 936156003670 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 936156003671 potential RNA of insufficient length (16S ribosomal RNA) 936156003672 Predicted membrane protein [Function unknown]; Region: COG3859 936156003673 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 936156003674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156003675 Coenzyme A binding pocket [chemical binding]; other site 936156003676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 936156003677 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 936156003678 DinB superfamily; Region: DinB_2; pfam12867 936156003679 MOSC domain; Region: MOSC; pfam03473 936156003680 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 936156003681 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 936156003682 active site 936156003683 NAD binding site [chemical binding]; other site 936156003684 metal binding site [ion binding]; metal-binding site 936156003685 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 936156003686 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 936156003687 tetramerization interface [polypeptide binding]; other site 936156003688 NAD(P) binding site [chemical binding]; other site 936156003689 catalytic residues [active] 936156003690 Predicted transcriptional regulators [Transcription]; Region: COG1510 936156003691 MarR family; Region: MarR_2; pfam12802 936156003692 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 936156003693 TrkA-N domain; Region: TrkA_N; pfam02254 936156003694 TrkA-C domain; Region: TrkA_C; pfam02080 936156003695 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 936156003696 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 936156003697 Predicted membrane protein [Function unknown]; Region: COG4682 936156003698 yiaA/B two helix domain; Region: YiaAB; pfam05360 936156003699 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 936156003700 SH3-like domain; Region: SH3_8; pfam13457 936156003701 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156003702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156003703 putative substrate translocation pore; other site 936156003704 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 936156003705 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 936156003706 Domain of unknown function DUF20; Region: UPF0118; pfam01594 936156003707 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 936156003708 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 936156003709 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936156003710 L-rhamnose isomerase (RhaA); Region: RhaA; pfam06134 936156003711 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 936156003712 Domain of unknown function (DUF718); Region: DUF718; cl01281 936156003713 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 936156003714 N- and C-terminal domain interface [polypeptide binding]; other site 936156003715 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 936156003716 active site 936156003717 putative catalytic site [active] 936156003718 metal binding site [ion binding]; metal-binding site 936156003719 ATP binding site [chemical binding]; other site 936156003720 carbohydrate binding site [chemical binding]; other site 936156003721 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936156003722 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 936156003723 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936156003724 short chain dehydrogenase; Validated; Region: PRK08324 936156003725 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 936156003726 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 936156003727 putative NAD(P) binding site [chemical binding]; other site 936156003728 active site 936156003729 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 936156003730 Cache domain; Region: Cache_1; pfam02743 936156003731 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936156003732 dimerization interface [polypeptide binding]; other site 936156003733 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936156003734 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936156003735 dimer interface [polypeptide binding]; other site 936156003736 putative CheW interface [polypeptide binding]; other site 936156003737 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936156003738 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 936156003739 Cache domain; Region: Cache_1; pfam02743 936156003740 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936156003741 dimerization interface [polypeptide binding]; other site 936156003742 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936156003743 dimer interface [polypeptide binding]; other site 936156003744 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 936156003745 putative CheW interface [polypeptide binding]; other site 936156003746 potential frameshift: common BLAST hit: gi|16080177|ref|NP_391003.1| methyl-accepting chemotaxis protein 936156003747 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 936156003748 Cache domain; Region: Cache_1; pfam02743 936156003749 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936156003750 dimerization interface [polypeptide binding]; other site 936156003751 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936156003752 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936156003753 dimer interface [polypeptide binding]; other site 936156003754 putative CheW interface [polypeptide binding]; other site 936156003755 transglutaminase; Provisional; Region: tgl; PRK03187 936156003756 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 936156003757 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 936156003758 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 936156003759 Ca binding site [ion binding]; other site 936156003760 active site 936156003761 catalytic site [active] 936156003762 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 936156003763 Domain of unknown function DUF21; Region: DUF21; pfam01595 936156003764 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 936156003765 Transporter associated domain; Region: CorC_HlyC; smart01091 936156003766 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 936156003767 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 936156003768 Ion channel; Region: Ion_trans_2; pfam07885 936156003769 TrkA-N domain; Region: TrkA_N; pfam02254 936156003770 YugN-like family; Region: YugN; pfam08868 936156003771 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 936156003772 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 936156003773 active site 936156003774 dimer interface [polypeptide binding]; other site 936156003775 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 936156003776 dimer interface [polypeptide binding]; other site 936156003777 active site 936156003778 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 936156003779 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 936156003780 dimer interface [polypeptide binding]; other site 936156003781 active site 936156003782 metal binding site [ion binding]; metal-binding site 936156003783 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 936156003784 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 936156003785 dimer interface [polypeptide binding]; other site 936156003786 active site 936156003787 metal binding site [ion binding]; metal-binding site 936156003788 Uncharacterized conserved protein [Function unknown]; Region: COG2155 936156003789 general stress protein 13; Validated; Region: PRK08059 936156003790 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 936156003791 RNA binding site [nucleotide binding]; other site 936156003792 hypothetical protein; Validated; Region: PRK07682 936156003793 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156003794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156003795 homodimer interface [polypeptide binding]; other site 936156003796 catalytic residue [active] 936156003797 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 936156003798 AsnC family; Region: AsnC_trans_reg; pfam01037 936156003799 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 936156003800 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 936156003801 nucleophilic elbow; other site 936156003802 catalytic triad; other site 936156003803 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 936156003804 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 936156003805 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156003806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156003807 homodimer interface [polypeptide binding]; other site 936156003808 catalytic residue [active] 936156003809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936156003810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156003811 dimer interface [polypeptide binding]; other site 936156003812 phosphorylation site [posttranslational modification] 936156003813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156003814 ATP binding site [chemical binding]; other site 936156003815 Mg2+ binding site [ion binding]; other site 936156003816 G-X-G motif; other site 936156003817 Kinase associated protein B; Region: KapB; pfam08810 936156003818 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 936156003819 active site 936156003820 catalytic site [active] 936156003821 substrate binding site [chemical binding]; other site 936156003822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156003823 putative substrate translocation pore; other site 936156003824 Transglycosylase; Region: Transgly; pfam00912 936156003825 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 936156003826 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 936156003827 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 936156003828 Meckelin (Transmembrane protein 67); Region: Meckelin; pfam09773 936156003829 sensory histidine kinase DcuS; Provisional; Region: PRK11086 936156003830 PAS domain; Region: PAS; smart00091 936156003831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156003832 ATP binding site [chemical binding]; other site 936156003833 G-X-G motif; other site 936156003834 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 936156003835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156003836 active site 936156003837 phosphorylation site [posttranslational modification] 936156003838 intermolecular recognition site; other site 936156003839 dimerization interface [polypeptide binding]; other site 936156003840 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 936156003841 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 936156003842 ligand binding site [chemical binding]; other site 936156003843 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 936156003844 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 936156003845 Walker A/P-loop; other site 936156003846 ATP binding site [chemical binding]; other site 936156003847 Q-loop/lid; other site 936156003848 ABC transporter signature motif; other site 936156003849 Walker B; other site 936156003850 D-loop; other site 936156003851 H-loop/switch region; other site 936156003852 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 936156003853 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 936156003854 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 936156003855 TM-ABC transporter signature motif; other site 936156003856 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 936156003857 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 936156003858 TM-ABC transporter signature motif; other site 936156003859 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 936156003860 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 936156003861 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 936156003862 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 936156003863 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 936156003864 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 936156003865 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 936156003866 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 936156003867 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 936156003868 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 936156003869 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 936156003870 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 936156003871 CoenzymeA binding site [chemical binding]; other site 936156003872 subunit interaction site [polypeptide binding]; other site 936156003873 PHB binding site; other site 936156003874 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936156003875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156003876 active site 936156003877 phosphorylation site [posttranslational modification] 936156003878 intermolecular recognition site; other site 936156003879 dimerization interface [polypeptide binding]; other site 936156003880 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936156003881 DNA binding residues [nucleotide binding] 936156003882 dimerization interface [polypeptide binding]; other site 936156003883 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 936156003884 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 936156003885 Protein of unknown function (DUF2704); Region: DUF2704; pfam10866 936156003886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 936156003887 Histidine kinase; Region: HisKA_3; pfam07730 936156003888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156003889 ATP binding site [chemical binding]; other site 936156003890 Mg2+ binding site [ion binding]; other site 936156003891 G-X-G motif; other site 936156003892 Bacillus competence pheromone ComX; Region: ComX; pfam05952 936156003893 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 936156003894 substrate binding pocket [chemical binding]; other site 936156003895 substrate-Mg2+ binding site; other site 936156003896 aspartate-rich region 1; other site 936156003897 DegQ (SacQ) family; Region: DegQ; pfam08181 936156003898 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 936156003899 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936156003900 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 936156003901 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 936156003902 active site 936156003903 Isochorismatase family; Region: Isochorismatase; pfam00857 936156003904 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 936156003905 catalytic triad [active] 936156003906 conserved cis-peptide bond; other site 936156003907 Uncharacterized conserved protein [Function unknown]; Region: COG5506 936156003908 YueH-like protein; Region: YueH; pfam14166 936156003909 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 936156003910 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 936156003911 Domain of unknown function DUF20; Region: UPF0118; pfam01594 936156003912 Uncharacterized conserved small protein [Function unknown]; Region: COG5428 936156003913 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 936156003914 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 936156003915 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936156003916 Zn2+ binding site [ion binding]; other site 936156003917 Mg2+ binding site [ion binding]; other site 936156003918 short chain dehydrogenase; Provisional; Region: PRK06924 936156003919 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 936156003920 NADP binding site [chemical binding]; other site 936156003921 homodimer interface [polypeptide binding]; other site 936156003922 active site 936156003923 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 936156003924 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 936156003925 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 936156003926 Predicted membrane protein [Function unknown]; Region: COG1511 936156003927 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 936156003928 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 936156003929 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 936156003930 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 936156003931 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 936156003932 Domain of unknown function DUF87; Region: DUF87; pfam01935 936156003933 Predicted membrane protein [Function unknown]; Region: COG4499 936156003934 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 936156003935 Uncharacterized small protein [Function unknown]; Region: COG5417 936156003936 Ubiquitin homologues; Region: UBQ; smart00213 936156003937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 936156003938 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 936156003939 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 936156003940 alanine dehydrogenase; Region: alaDH; TIGR00518 936156003941 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 936156003942 hexamer interface [polypeptide binding]; other site 936156003943 ligand binding site [chemical binding]; other site 936156003944 putative active site [active] 936156003945 NAD(P) binding site [chemical binding]; other site 936156003946 Uncharacterized conserved protein [Function unknown]; Region: COG5634 936156003947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 936156003948 Condensation domain; Region: Condensation; pfam00668 936156003949 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 936156003950 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 936156003951 acyl-activating enzyme (AAE) consensus motif; other site 936156003952 AMP binding site [chemical binding]; other site 936156003953 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156003954 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 936156003955 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 936156003956 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936156003957 acyl-activating enzyme (AAE) consensus motif; other site 936156003958 AMP binding site [chemical binding]; other site 936156003959 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156003960 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 936156003961 hydrophobic substrate binding pocket; other site 936156003962 Isochorismatase family; Region: Isochorismatase; pfam00857 936156003963 active site 936156003964 conserved cis-peptide bond; other site 936156003965 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 936156003966 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 936156003967 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 936156003968 acyl-activating enzyme (AAE) consensus motif; other site 936156003969 active site 936156003970 AMP binding site [chemical binding]; other site 936156003971 substrate binding site [chemical binding]; other site 936156003972 isochorismate synthase DhbC; Validated; Region: PRK06923 936156003973 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 936156003974 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 936156003975 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 936156003976 putative NAD(P) binding site [chemical binding]; other site 936156003977 active site 936156003978 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 936156003979 Putative esterase; Region: Esterase; pfam00756 936156003980 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 936156003981 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 936156003982 Moco binding site; other site 936156003983 metal coordination site [ion binding]; other site 936156003984 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 936156003985 Predicted permease [General function prediction only]; Region: COG2056 936156003986 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 936156003987 multifunctional aminopeptidase A; Provisional; Region: PRK00913 936156003988 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 936156003989 interface (dimer of trimers) [polypeptide binding]; other site 936156003990 Substrate-binding/catalytic site; other site 936156003991 Zn-binding sites [ion binding]; other site 936156003992 Divergent PAP2 family; Region: DUF212; pfam02681 936156003993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 936156003994 Putative membrane protein; Region: YuiB; pfam14068 936156003995 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 936156003996 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 936156003997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936156003998 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 936156003999 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936156004000 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936156004001 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 936156004002 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 936156004003 active site 936156004004 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 936156004005 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 936156004006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156004007 Coenzyme A binding pocket [chemical binding]; other site 936156004008 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 936156004009 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 936156004010 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 936156004011 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 936156004012 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 936156004013 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 936156004014 Nucleoside recognition; Region: Gate; pfam07670 936156004015 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 936156004016 hypothetical protein; Provisional; Region: PRK13669 936156004017 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 936156004018 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936156004019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 936156004020 NifU-like domain; Region: NifU; pfam01106 936156004021 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 936156004022 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 936156004023 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 936156004024 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 936156004025 homoserine kinase; Region: thrB; TIGR00191 936156004026 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 936156004027 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 936156004028 threonine synthase; Reviewed; Region: PRK06721 936156004029 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 936156004030 homodimer interface [polypeptide binding]; other site 936156004031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156004032 catalytic residue [active] 936156004033 homoserine dehydrogenase; Provisional; Region: PRK06349 936156004034 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 936156004035 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 936156004036 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 936156004037 spore coat protein YutH; Region: spore_yutH; TIGR02905 936156004038 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 936156004039 tetramer interfaces [polypeptide binding]; other site 936156004040 binuclear metal-binding site [ion binding]; other site 936156004041 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 936156004042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156004043 active site 936156004044 motif I; other site 936156004045 motif II; other site 936156004046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156004047 Uncharacterized conserved protein [Function unknown]; Region: COG2445 936156004048 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 936156004049 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 936156004050 lipoyl synthase; Provisional; Region: PRK05481 936156004051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936156004052 FeS/SAM binding site; other site 936156004053 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 936156004054 Peptidase family M23; Region: Peptidase_M23; pfam01551 936156004055 sporulation protein YunB; Region: spo_yunB; TIGR02832 936156004056 Uncharacterized conserved protein [Function unknown]; Region: COG3377 936156004057 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 936156004058 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 936156004059 active site 936156004060 metal binding site [ion binding]; metal-binding site 936156004061 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 936156004062 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 936156004063 Uncharacterized conserved protein [Function unknown]; Region: COG1801 936156004064 allantoinase; Provisional; Region: PRK06189 936156004065 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 936156004066 active site 936156004067 DRTGG domain; Region: DRTGG; pfam07085 936156004068 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 936156004069 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 936156004070 xanthine permease; Region: pbuX; TIGR03173 936156004071 xanthine permease; Region: pbuX; TIGR03173 936156004072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 936156004073 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 936156004074 Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the...; Region: Uricase; cd00445 936156004075 tetramer interface [polypeptide binding]; other site 936156004076 active site 936156004077 Transthyretin-like protein [General function prediction only]; Region: COG2351 936156004078 active site 936156004079 homotetramer interface [polypeptide binding]; other site 936156004080 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 936156004081 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 936156004082 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 936156004083 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 936156004084 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 936156004085 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 936156004086 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 936156004087 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 936156004088 Ligand binding site; other site 936156004089 metal-binding site 936156004090 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 936156004091 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 936156004092 XdhC Rossmann domain; Region: XdhC_C; pfam13478 936156004093 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 936156004094 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936156004095 catalytic residue [active] 936156004096 allantoate amidohydrolase; Reviewed; Region: PRK09290 936156004097 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 936156004098 active site 936156004099 metal binding site [ion binding]; metal-binding site 936156004100 dimer interface [polypeptide binding]; other site 936156004101 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 936156004102 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 936156004103 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 936156004104 Walker A/P-loop; other site 936156004105 ATP binding site [chemical binding]; other site 936156004106 Q-loop/lid; other site 936156004107 ABC transporter signature motif; other site 936156004108 Walker B; other site 936156004109 D-loop; other site 936156004110 H-loop/switch region; other site 936156004111 TOBE domain; Region: TOBE_2; pfam08402 936156004112 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 936156004113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156004114 DNA-binding site [nucleotide binding]; DNA binding site 936156004115 UTRA domain; Region: UTRA; pfam07702 936156004116 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936156004117 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 936156004118 substrate binding site [chemical binding]; other site 936156004119 ATP binding site [chemical binding]; other site 936156004120 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 936156004121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156004122 dimer interface [polypeptide binding]; other site 936156004123 conserved gate region; other site 936156004124 putative PBP binding loops; other site 936156004125 ABC-ATPase subunit interface; other site 936156004126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156004127 dimer interface [polypeptide binding]; other site 936156004128 conserved gate region; other site 936156004129 putative PBP binding loops; other site 936156004130 ABC-ATPase subunit interface; other site 936156004131 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 936156004132 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 936156004133 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 936156004134 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 936156004135 putative active site [active] 936156004136 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 936156004137 dimer interface [polypeptide binding]; other site 936156004138 active site 936156004139 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 936156004140 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 936156004141 GIY-YIG motif/motif A; other site 936156004142 active site 936156004143 catalytic site [active] 936156004144 putative DNA binding site [nucleotide binding]; other site 936156004145 metal binding site [ion binding]; metal-binding site 936156004146 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 936156004147 hydroxyglutarate oxidase; Provisional; Region: PRK11728 936156004148 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 936156004149 FeS assembly protein SufB; Region: sufB; TIGR01980 936156004150 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 936156004151 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 936156004152 trimerization site [polypeptide binding]; other site 936156004153 active site 936156004154 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 936156004155 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 936156004156 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936156004157 catalytic residue [active] 936156004158 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 936156004159 FeS assembly protein SufD; Region: sufD; TIGR01981 936156004160 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 936156004161 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 936156004162 Walker A/P-loop; other site 936156004163 ATP binding site [chemical binding]; other site 936156004164 Q-loop/lid; other site 936156004165 ABC transporter signature motif; other site 936156004166 Walker B; other site 936156004167 D-loop; other site 936156004168 H-loop/switch region; other site 936156004169 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 936156004170 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 936156004171 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 936156004172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156004173 conserved gate region; other site 936156004174 ABC-ATPase subunit interface; other site 936156004175 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 936156004176 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 936156004177 Walker A/P-loop; other site 936156004178 ATP binding site [chemical binding]; other site 936156004179 Q-loop/lid; other site 936156004180 ABC transporter signature motif; other site 936156004181 Walker B; other site 936156004182 D-loop; other site 936156004183 H-loop/switch region; other site 936156004184 NIL domain; Region: NIL; pfam09383 936156004185 SCP-2 sterol transfer family; Region: SCP2; pfam02036 936156004186 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 936156004187 catalytic residues [active] 936156004188 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 936156004189 putative active site [active] 936156004190 putative metal binding site [ion binding]; other site 936156004191 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 936156004192 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 936156004193 lipoyl attachment site [posttranslational modification]; other site 936156004194 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 936156004195 ArsC family; Region: ArsC; pfam03960 936156004196 putative ArsC-like catalytic residues; other site 936156004197 putative TRX-like catalytic residues [active] 936156004198 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 936156004199 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 936156004200 active site 936156004201 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 936156004202 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 936156004203 dimer interface [polypeptide binding]; other site 936156004204 active site 936156004205 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 936156004206 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 936156004207 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 936156004208 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 936156004209 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 936156004210 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 936156004211 substrate binding site [chemical binding]; other site 936156004212 oxyanion hole (OAH) forming residues; other site 936156004213 trimer interface [polypeptide binding]; other site 936156004214 Proline dehydrogenase; Region: Pro_dh; pfam01619 936156004215 Coat F domain; Region: Coat_F; pfam07875 936156004216 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156004217 MarR family; Region: MarR; pfam01047 936156004218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156004219 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156004220 putative substrate translocation pore; other site 936156004221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156004222 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 936156004223 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 936156004224 classical (c) SDRs; Region: SDR_c; cd05233 936156004225 NAD(P) binding site [chemical binding]; other site 936156004226 active site 936156004227 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156004228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156004229 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 936156004230 dimerization interface [polypeptide binding]; other site 936156004231 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 936156004232 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 936156004233 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 936156004234 Walker A/P-loop; other site 936156004235 ATP binding site [chemical binding]; other site 936156004236 Q-loop/lid; other site 936156004237 ABC transporter signature motif; other site 936156004238 Walker B; other site 936156004239 D-loop; other site 936156004240 H-loop/switch region; other site 936156004241 YusW-like protein; Region: YusW; pfam14039 936156004242 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 936156004243 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 936156004244 active site 936156004245 Zn binding site [ion binding]; other site 936156004246 short chain dehydrogenase; Provisional; Region: PRK06914 936156004247 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 936156004248 NADP binding site [chemical binding]; other site 936156004249 active site 936156004250 steroid binding site; other site 936156004251 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 936156004252 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 936156004253 dimerization interface [polypeptide binding]; other site 936156004254 DPS ferroxidase diiron center [ion binding]; other site 936156004255 ion pore; other site 936156004256 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 936156004257 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 936156004258 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 936156004259 protein binding site [polypeptide binding]; other site 936156004260 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936156004261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156004262 active site 936156004263 phosphorylation site [posttranslational modification] 936156004264 intermolecular recognition site; other site 936156004265 dimerization interface [polypeptide binding]; other site 936156004266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936156004267 DNA binding site [nucleotide binding] 936156004268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936156004269 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936156004270 dimerization interface [polypeptide binding]; other site 936156004271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156004272 dimer interface [polypeptide binding]; other site 936156004273 phosphorylation site [posttranslational modification] 936156004274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156004275 ATP binding site [chemical binding]; other site 936156004276 Mg2+ binding site [ion binding]; other site 936156004277 G-X-G motif; other site 936156004278 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156004279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156004280 fumarate hydratase; Reviewed; Region: fumC; PRK00485 936156004281 Class II fumarases; Region: Fumarase_classII; cd01362 936156004282 active site 936156004283 tetramer interface [polypeptide binding]; other site 936156004284 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 936156004285 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 936156004286 Spore germination protein; Region: Spore_permease; pfam03845 936156004287 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 936156004288 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 936156004289 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936156004290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156004291 active site 936156004292 phosphorylation site [posttranslational modification] 936156004293 intermolecular recognition site; other site 936156004294 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936156004295 DNA binding residues [nucleotide binding] 936156004296 dimerization interface [polypeptide binding]; other site 936156004297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 936156004298 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936156004299 dimerization interface [polypeptide binding]; other site 936156004300 Histidine kinase; Region: HisKA_3; pfam07730 936156004301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156004302 ATP binding site [chemical binding]; other site 936156004303 Mg2+ binding site [ion binding]; other site 936156004304 G-X-G motif; other site 936156004305 Predicted membrane protein [Function unknown]; Region: COG4758 936156004306 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 936156004307 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 936156004308 Uncharacterized conserved protein [Function unknown]; Region: COG3595 936156004309 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 936156004310 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 936156004311 PspA/IM30 family; Region: PspA_IM30; pfam04012 936156004312 H+ Antiporter protein; Region: 2A0121; TIGR00900 936156004313 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 936156004314 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 936156004315 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 936156004316 Walker A/P-loop; other site 936156004317 ATP binding site [chemical binding]; other site 936156004318 Q-loop/lid; other site 936156004319 ABC transporter signature motif; other site 936156004320 Walker B; other site 936156004321 D-loop; other site 936156004322 H-loop/switch region; other site 936156004323 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 936156004324 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 936156004325 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156004326 ABC-ATPase subunit interface; other site 936156004327 dimer interface [polypeptide binding]; other site 936156004328 putative PBP binding regions; other site 936156004329 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 936156004330 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 936156004331 putative binding site residues; other site 936156004332 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 936156004333 classical (c) SDRs; Region: SDR_c; cd05233 936156004334 NAD(P) binding site [chemical binding]; other site 936156004335 active site 936156004336 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 936156004337 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936156004338 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156004339 dimer interface [polypeptide binding]; other site 936156004340 phosphorylation site [posttranslational modification] 936156004341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156004342 ATP binding site [chemical binding]; other site 936156004343 Mg2+ binding site [ion binding]; other site 936156004344 G-X-G motif; other site 936156004345 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936156004346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156004347 active site 936156004348 phosphorylation site [posttranslational modification] 936156004349 intermolecular recognition site; other site 936156004350 dimerization interface [polypeptide binding]; other site 936156004351 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936156004352 DNA binding site [nucleotide binding] 936156004353 hypothetical protein; Provisional; Region: PRK14082 936156004354 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 936156004355 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156004356 DNA binding residues [nucleotide binding] 936156004357 YvrJ protein family; Region: YvrJ; pfam12841 936156004358 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 936156004359 Cupin; Region: Cupin_1; smart00835 936156004360 Cupin; Region: Cupin_1; smart00835 936156004361 Regulatory protein YrvL; Region: YrvL; pfam14184 936156004362 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 936156004363 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 936156004364 FtsX-like permease family; Region: FtsX; pfam02687 936156004365 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 936156004366 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 936156004367 Walker A/P-loop; other site 936156004368 ATP binding site [chemical binding]; other site 936156004369 Q-loop/lid; other site 936156004370 ABC transporter signature motif; other site 936156004371 Walker B; other site 936156004372 D-loop; other site 936156004373 H-loop/switch region; other site 936156004374 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 936156004375 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936156004376 DNA damage checkpoint protein; Region: LCD1; pfam09798 936156004377 HlyD family secretion protein; Region: HlyD_3; pfam13437 936156004378 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 936156004379 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 936156004380 Walker A/P-loop; other site 936156004381 ATP binding site [chemical binding]; other site 936156004382 Q-loop/lid; other site 936156004383 ABC transporter signature motif; other site 936156004384 Walker B; other site 936156004385 D-loop; other site 936156004386 H-loop/switch region; other site 936156004387 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 936156004388 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156004389 ABC-ATPase subunit interface; other site 936156004390 dimer interface [polypeptide binding]; other site 936156004391 putative PBP binding regions; other site 936156004392 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 936156004393 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156004394 ABC-ATPase subunit interface; other site 936156004395 dimer interface [polypeptide binding]; other site 936156004396 putative PBP binding regions; other site 936156004397 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 936156004398 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 936156004399 putative ligand binding residues [chemical binding]; other site 936156004400 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 936156004401 Spore germination protein; Region: Spore_permease; cl17796 936156004402 small, acid-soluble spore protein, SspJ family; Region: spore_sspJ; TIGR02863 936156004403 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 936156004404 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 936156004405 Sulfatase; Region: Sulfatase; pfam00884 936156004406 DNA binding domain, excisionase family; Region: excise; TIGR01764 936156004407 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 936156004408 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 936156004409 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 936156004410 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 936156004411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156004412 dimer interface [polypeptide binding]; other site 936156004413 conserved gate region; other site 936156004414 putative PBP binding loops; other site 936156004415 ABC-ATPase subunit interface; other site 936156004416 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936156004417 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936156004418 active site 936156004419 catalytic tetrad [active] 936156004420 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 936156004421 sulfite reductase subunit beta; Provisional; Region: PRK13504 936156004422 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 936156004423 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 936156004424 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 936156004425 Flavodoxin; Region: Flavodoxin_1; pfam00258 936156004426 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 936156004427 FAD binding pocket [chemical binding]; other site 936156004428 FAD binding motif [chemical binding]; other site 936156004429 catalytic residues [active] 936156004430 NAD binding pocket [chemical binding]; other site 936156004431 phosphate binding motif [ion binding]; other site 936156004432 beta-alpha-beta structure motif; other site 936156004433 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 936156004434 Part of AAA domain; Region: AAA_19; pfam13245 936156004435 Family description; Region: UvrD_C_2; pfam13538 936156004436 Predicted membrane protein [Function unknown]; Region: COG2860 936156004437 UPF0126 domain; Region: UPF0126; pfam03458 936156004438 UPF0126 domain; Region: UPF0126; pfam03458 936156004439 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 936156004440 Thioredoxin; Region: Thioredoxin_4; pfam13462 936156004441 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 936156004442 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 936156004443 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 936156004444 metal-binding site [ion binding] 936156004445 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 936156004446 Soluble P-type ATPase [General function prediction only]; Region: COG4087 936156004447 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 936156004448 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 936156004449 metal-binding site [ion binding] 936156004450 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 936156004451 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 936156004452 metal-binding site [ion binding] 936156004453 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 936156004454 Soluble P-type ATPase [General function prediction only]; Region: COG4087 936156004455 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 936156004456 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 936156004457 metal-binding site [ion binding] 936156004458 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 936156004459 putative homodimer interface [polypeptide binding]; other site 936156004460 putative homotetramer interface [polypeptide binding]; other site 936156004461 allosteric switch controlling residues; other site 936156004462 putative metal binding site [ion binding]; other site 936156004463 putative homodimer-homodimer interface [polypeptide binding]; other site 936156004464 putative oxidoreductase; Provisional; Region: PRK11579 936156004465 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936156004466 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 936156004467 azoreductase; Reviewed; Region: PRK00170 936156004468 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 936156004469 Predicted membrane protein [Function unknown]; Region: COG1289 936156004470 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 936156004471 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 936156004472 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 936156004473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156004474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156004475 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 936156004476 classical (c) SDRs; Region: SDR_c; cd05233 936156004477 NAD(P) binding site [chemical binding]; other site 936156004478 active site 936156004479 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 936156004480 SmpB-tmRNA interface; other site 936156004481 ribonuclease R; Region: RNase_R; TIGR02063 936156004482 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 936156004483 Cold shock protein domain; Region: CSP; smart00357 936156004484 RNB domain; Region: RNB; pfam00773 936156004485 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 936156004486 RNA binding site [nucleotide binding]; other site 936156004487 Esterase/lipase [General function prediction only]; Region: COG1647 936156004488 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 936156004489 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 936156004490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156004491 salt bridge; other site 936156004492 non-specific DNA binding site [nucleotide binding]; other site 936156004493 sequence-specific DNA binding site [nucleotide binding]; other site 936156004494 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936156004495 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156004496 non-specific DNA binding site [nucleotide binding]; other site 936156004497 salt bridge; other site 936156004498 sequence-specific DNA binding site [nucleotide binding]; other site 936156004499 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936156004500 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936156004501 dimer interface [polypeptide binding]; other site 936156004502 putative CheW interface [polypeptide binding]; other site 936156004503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156004504 dimer interface [polypeptide binding]; other site 936156004505 conserved gate region; other site 936156004506 putative PBP binding loops; other site 936156004507 ABC-ATPase subunit interface; other site 936156004508 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 936156004509 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 936156004510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156004511 dimer interface [polypeptide binding]; other site 936156004512 conserved gate region; other site 936156004513 putative PBP binding loops; other site 936156004514 ABC-ATPase subunit interface; other site 936156004515 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 936156004516 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 936156004517 Walker A/P-loop; other site 936156004518 ATP binding site [chemical binding]; other site 936156004519 Q-loop/lid; other site 936156004520 ABC transporter signature motif; other site 936156004521 Walker B; other site 936156004522 D-loop; other site 936156004523 H-loop/switch region; other site 936156004524 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 936156004525 Predicted transcriptional regulators [Transcription]; Region: COG1510 936156004526 MarR family; Region: MarR_2; pfam12802 936156004527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156004528 dimer interface [polypeptide binding]; other site 936156004529 conserved gate region; other site 936156004530 putative PBP binding loops; other site 936156004531 ABC-ATPase subunit interface; other site 936156004532 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 936156004533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156004534 dimer interface [polypeptide binding]; other site 936156004535 conserved gate region; other site 936156004536 putative PBP binding loops; other site 936156004537 ABC-ATPase subunit interface; other site 936156004538 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 936156004539 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 936156004540 Walker A/P-loop; other site 936156004541 ATP binding site [chemical binding]; other site 936156004542 Q-loop/lid; other site 936156004543 ABC transporter signature motif; other site 936156004544 Walker B; other site 936156004545 D-loop; other site 936156004546 H-loop/switch region; other site 936156004547 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 936156004548 Predicted transcriptional regulators [Transcription]; Region: COG1510 936156004549 MarR family; Region: MarR_2; pfam12802 936156004550 membrane protein, MarC family; Region: TIGR00427 936156004551 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 936156004552 pentamer interface [polypeptide binding]; other site 936156004553 dodecaamer interface [polypeptide binding]; other site 936156004554 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 936156004555 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 936156004556 Double zinc ribbon; Region: DZR; pfam12773 936156004557 Predicted membrane protein [Function unknown]; Region: COG4640 936156004558 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 936156004559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156004560 Coenzyme A binding pocket [chemical binding]; other site 936156004561 H+ Antiporter protein; Region: 2A0121; TIGR00900 936156004562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156004563 putative substrate translocation pore; other site 936156004564 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 936156004565 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 936156004566 WbqC-like protein family; Region: WbqC; pfam08889 936156004567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 936156004568 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 936156004569 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 936156004570 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936156004571 catalytic residue [active] 936156004572 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 936156004573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 936156004574 NAD(P) binding site [chemical binding]; other site 936156004575 active site 936156004576 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 936156004577 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 936156004578 inhibitor-cofactor binding pocket; inhibition site 936156004579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156004580 catalytic residue [active] 936156004581 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 936156004582 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 936156004583 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 936156004584 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 936156004585 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 936156004586 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 936156004587 putative integrin binding motif; other site 936156004588 PA/protease domain interface [polypeptide binding]; other site 936156004589 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 936156004590 Peptidase family M28; Region: Peptidase_M28; pfam04389 936156004591 metal binding site [ion binding]; metal-binding site 936156004592 enolase; Provisional; Region: eno; PRK00077 936156004593 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 936156004594 dimer interface [polypeptide binding]; other site 936156004595 metal binding site [ion binding]; metal-binding site 936156004596 substrate binding pocket [chemical binding]; other site 936156004597 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 936156004598 phosphoglyceromutase; Provisional; Region: PRK05434 936156004599 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 936156004600 triosephosphate isomerase; Provisional; Region: PRK14565 936156004601 substrate binding site [chemical binding]; other site 936156004602 dimer interface [polypeptide binding]; other site 936156004603 catalytic triad [active] 936156004604 Phosphoglycerate kinase; Region: PGK; pfam00162 936156004605 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 936156004606 substrate binding site [chemical binding]; other site 936156004607 hinge regions; other site 936156004608 ADP binding site [chemical binding]; other site 936156004609 catalytic site [active] 936156004610 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 936156004611 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 936156004612 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 936156004613 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 936156004614 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 936156004615 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 936156004616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156004617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156004618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156004619 DNA-binding site [nucleotide binding]; DNA binding site 936156004620 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936156004621 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 936156004622 putative dimerization interface [polypeptide binding]; other site 936156004623 putative ligand binding site [chemical binding]; other site 936156004624 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 936156004625 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 936156004626 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 936156004627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156004628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156004629 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936156004630 dimerization interface [polypeptide binding]; other site 936156004631 EamA-like transporter family; Region: EamA; pfam00892 936156004632 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 936156004633 EamA-like transporter family; Region: EamA; pfam00892 936156004634 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 936156004635 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 936156004636 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 936156004637 active site 936156004638 Uncharacterized conserved protein [Function unknown]; Region: COG1556 936156004639 iron-sulfur cluster-binding protein; Region: TIGR00273 936156004640 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 936156004641 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 936156004642 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 936156004643 Cysteine-rich domain; Region: CCG; pfam02754 936156004644 Cysteine-rich domain; Region: CCG; pfam02754 936156004645 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936156004646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156004647 active site 936156004648 phosphorylation site [posttranslational modification] 936156004649 intermolecular recognition site; other site 936156004650 dimerization interface [polypeptide binding]; other site 936156004651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936156004652 DNA binding residues [nucleotide binding] 936156004653 dimerization interface [polypeptide binding]; other site 936156004654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 936156004655 Histidine kinase; Region: HisKA_3; pfam07730 936156004656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156004657 ATP binding site [chemical binding]; other site 936156004658 Mg2+ binding site [ion binding]; other site 936156004659 G-X-G motif; other site 936156004660 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 936156004661 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 936156004662 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 936156004663 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 936156004664 Walker A/P-loop; other site 936156004665 ATP binding site [chemical binding]; other site 936156004666 Q-loop/lid; other site 936156004667 ABC transporter signature motif; other site 936156004668 Walker B; other site 936156004669 D-loop; other site 936156004670 H-loop/switch region; other site 936156004671 potential frameshift: common BLAST hit: gi|16080463|ref|NP_391290.1| regulator of RsbP phosphatase 936156004672 PAS domain S-box; Region: sensory_box; TIGR00229 936156004673 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156004674 putative active site [active] 936156004675 heme pocket [chemical binding]; other site 936156004676 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 936156004677 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 936156004678 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 936156004679 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 936156004680 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 936156004681 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 936156004682 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 936156004683 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 936156004684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156004685 dimer interface [polypeptide binding]; other site 936156004686 conserved gate region; other site 936156004687 putative PBP binding loops; other site 936156004688 ABC-ATPase subunit interface; other site 936156004689 TM2 domain; Region: TM2; pfam05154 936156004690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156004691 dimer interface [polypeptide binding]; other site 936156004692 conserved gate region; other site 936156004693 ABC-ATPase subunit interface; other site 936156004694 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 936156004695 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 936156004696 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936156004697 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936156004698 DNA binding site [nucleotide binding] 936156004699 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 936156004700 putative dimerization interface [polypeptide binding]; other site 936156004701 putative ligand binding site [chemical binding]; other site 936156004702 Transcriptional regulators [Transcription]; Region: FadR; COG2186 936156004703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156004704 DNA-binding site [nucleotide binding]; DNA binding site 936156004705 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 936156004706 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 936156004707 L-lactate permease; Region: Lactate_perm; pfam02652 936156004708 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 936156004709 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 936156004710 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 936156004711 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 936156004712 YvfG protein; Region: YvfG; pfam09628 936156004713 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 936156004714 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 936156004715 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 936156004716 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 936156004717 inhibitor-cofactor binding pocket; inhibition site 936156004718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156004719 catalytic residue [active] 936156004720 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 936156004721 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 936156004722 putative trimer interface [polypeptide binding]; other site 936156004723 putative CoA binding site [chemical binding]; other site 936156004724 Bacterial sugar transferase; Region: Bac_transf; pfam02397 936156004725 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 936156004726 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 936156004727 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 936156004728 active site 936156004729 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 936156004730 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 936156004731 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 936156004732 active site 936156004733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936156004734 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 936156004735 putative ADP-binding pocket [chemical binding]; other site 936156004736 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 936156004737 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 936156004738 active site 936156004739 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 936156004740 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936156004741 putative ADP-binding pocket [chemical binding]; other site 936156004742 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 936156004743 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 936156004744 NAD(P) binding site [chemical binding]; other site 936156004745 homodimer interface [polypeptide binding]; other site 936156004746 substrate binding site [chemical binding]; other site 936156004747 active site 936156004748 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 936156004749 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 936156004750 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 936156004751 Chain length determinant protein; Region: Wzz; cl15801 936156004752 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936156004753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156004754 non-specific DNA binding site [nucleotide binding]; other site 936156004755 salt bridge; other site 936156004756 sequence-specific DNA binding site [nucleotide binding]; other site 936156004757 Anti-repressor SinI; Region: SinI; pfam08671 936156004758 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 936156004759 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 936156004760 substrate binding pocket [chemical binding]; other site 936156004761 catalytic triad [active] 936156004762 Phenolic acid decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3479 936156004763 hypothetical protein; Provisional; Region: PRK00872 936156004764 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 936156004765 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 936156004766 Beta-lactamase; Region: Beta-lactamase; pfam00144 936156004767 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 936156004768 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 936156004769 active site 936156004770 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 936156004771 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 936156004772 substrate binding [chemical binding]; other site 936156004773 active site 936156004774 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 936156004775 amino acid transporter; Region: 2A0306; TIGR00909 936156004776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156004777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156004778 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 936156004779 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 936156004780 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 936156004781 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 936156004782 FAD binding domain; Region: FAD_binding_4; pfam01565 936156004783 Berberine and berberine like; Region: BBE; pfam08031 936156004784 Patatin [General function prediction only]; Region: COG3621 936156004785 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 936156004786 active site 936156004787 nucleophile elbow; other site 936156004788 Clp protease; Region: CLP_protease; pfam00574 936156004789 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 936156004790 oligomer interface [polypeptide binding]; other site 936156004791 active site residues [active] 936156004792 beta-phosphoglucomutase; Region: bPGM; TIGR01990 936156004793 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156004794 motif II; other site 936156004795 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 936156004796 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 936156004797 Ca binding site [ion binding]; other site 936156004798 active site 936156004799 catalytic site [active] 936156004800 maltose phosphorylase; Provisional; Region: PRK13807 936156004801 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 936156004802 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 936156004803 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 936156004804 Predicted integral membrane protein [Function unknown]; Region: COG5521 936156004805 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 936156004806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156004807 dimer interface [polypeptide binding]; other site 936156004808 conserved gate region; other site 936156004809 ABC-ATPase subunit interface; other site 936156004810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156004811 dimer interface [polypeptide binding]; other site 936156004812 conserved gate region; other site 936156004813 putative PBP binding loops; other site 936156004814 ABC-ATPase subunit interface; other site 936156004815 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 936156004816 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 936156004817 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 936156004818 homodimer interface [polypeptide binding]; other site 936156004819 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 936156004820 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 936156004821 active site 936156004822 homodimer interface [polypeptide binding]; other site 936156004823 catalytic site [active] 936156004824 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936156004825 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936156004826 DNA binding site [nucleotide binding] 936156004827 domain linker motif; other site 936156004828 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 936156004829 ligand binding site [chemical binding]; other site 936156004830 dimerization interface [polypeptide binding]; other site 936156004831 TIGR00730 family protein; Region: TIGR00730 936156004832 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 936156004833 metal binding site [ion binding]; metal-binding site 936156004834 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 936156004835 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 936156004836 Sulfate transporter family; Region: Sulfate_transp; pfam00916 936156004837 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 936156004838 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 936156004839 active site clefts [active] 936156004840 zinc binding site [ion binding]; other site 936156004841 dimer interface [polypeptide binding]; other site 936156004842 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 936156004843 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 936156004844 dimerization interface [polypeptide binding]; other site 936156004845 ligand binding site [chemical binding]; other site 936156004846 NADP binding site [chemical binding]; other site 936156004847 catalytic site [active] 936156004848 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 936156004849 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 936156004850 Walker A/P-loop; other site 936156004851 ATP binding site [chemical binding]; other site 936156004852 Q-loop/lid; other site 936156004853 ABC transporter signature motif; other site 936156004854 Walker B; other site 936156004855 D-loop; other site 936156004856 H-loop/switch region; other site 936156004857 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936156004858 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 936156004859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156004860 ATP binding site [chemical binding]; other site 936156004861 Mg2+ binding site [ion binding]; other site 936156004862 G-X-G motif; other site 936156004863 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936156004864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156004865 active site 936156004866 phosphorylation site [posttranslational modification] 936156004867 intermolecular recognition site; other site 936156004868 dimerization interface [polypeptide binding]; other site 936156004869 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936156004870 DNA binding site [nucleotide binding] 936156004871 Lysis protein; Region: Lysis_col; pfam02402 936156004872 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 936156004873 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 936156004874 dimerization domain swap beta strand [polypeptide binding]; other site 936156004875 regulatory protein interface [polypeptide binding]; other site 936156004876 active site 936156004877 regulatory phosphorylation site [posttranslational modification]; other site 936156004878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 936156004879 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 936156004880 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 936156004881 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 936156004882 phosphate binding site [ion binding]; other site 936156004883 putative substrate binding pocket [chemical binding]; other site 936156004884 dimer interface [polypeptide binding]; other site 936156004885 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 936156004886 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 936156004887 putative active site [active] 936156004888 nucleotide binding site [chemical binding]; other site 936156004889 nudix motif; other site 936156004890 putative metal binding site [ion binding]; other site 936156004891 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 936156004892 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936156004893 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936156004894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 936156004895 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 936156004896 NlpC/P60 family; Region: NLPC_P60; pfam00877 936156004897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156004898 binding surface 936156004899 Tetratricopeptide repeat; Region: TPR_16; pfam13432 936156004900 TPR motif; other site 936156004901 Tetratricopeptide repeat; Region: TPR_16; pfam13432 936156004902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156004903 TPR motif; other site 936156004904 binding surface 936156004905 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 936156004906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936156004907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936156004908 Walker A/P-loop; other site 936156004909 ATP binding site [chemical binding]; other site 936156004910 Q-loop/lid; other site 936156004911 ABC transporter signature motif; other site 936156004912 Walker B; other site 936156004913 D-loop; other site 936156004914 H-loop/switch region; other site 936156004915 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 936156004916 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 936156004917 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 936156004918 metal binding site [ion binding]; metal-binding site 936156004919 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 936156004920 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 936156004921 substrate binding site [chemical binding]; other site 936156004922 glutamase interaction surface [polypeptide binding]; other site 936156004923 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 936156004924 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 936156004925 catalytic residues [active] 936156004926 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 936156004927 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 936156004928 putative active site [active] 936156004929 oxyanion strand; other site 936156004930 catalytic triad [active] 936156004931 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 936156004932 putative active site pocket [active] 936156004933 4-fold oligomerization interface [polypeptide binding]; other site 936156004934 metal binding residues [ion binding]; metal-binding site 936156004935 3-fold/trimer interface [polypeptide binding]; other site 936156004936 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 936156004937 histidinol dehydrogenase; Region: hisD; TIGR00069 936156004938 NAD binding site [chemical binding]; other site 936156004939 dimerization interface [polypeptide binding]; other site 936156004940 product binding site; other site 936156004941 substrate binding site [chemical binding]; other site 936156004942 zinc binding site [ion binding]; other site 936156004943 catalytic residues [active] 936156004944 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 936156004945 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 936156004946 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 936156004947 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 936156004948 dimer interface [polypeptide binding]; other site 936156004949 motif 1; other site 936156004950 active site 936156004951 motif 2; other site 936156004952 motif 3; other site 936156004953 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 936156004954 putative active site [active] 936156004955 Pectate lyase; Region: Pectate_lyase; pfam03211 936156004956 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 936156004957 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 936156004958 CoA binding site [chemical binding]; other site 936156004959 active site 936156004960 pyrophosphatase PpaX; Provisional; Region: PRK13288 936156004961 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 936156004962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156004963 motif II; other site 936156004964 Nucleoside recognition; Region: Gate; pfam07670 936156004965 Nucleoside recognition; Region: Gate; pfam07670 936156004966 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 936156004967 HPr kinase/phosphorylase; Provisional; Region: PRK05428 936156004968 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 936156004969 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 936156004970 Hpr binding site; other site 936156004971 active site 936156004972 homohexamer subunit interaction site [polypeptide binding]; other site 936156004973 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 936156004974 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 936156004975 active site 936156004976 dimer interface [polypeptide binding]; other site 936156004977 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 936156004978 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 936156004979 active site 936156004980 trimer interface [polypeptide binding]; other site 936156004981 allosteric site; other site 936156004982 active site lid [active] 936156004983 hexamer (dimer of trimers) interface [polypeptide binding]; other site 936156004984 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 936156004985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156004986 DNA-binding site [nucleotide binding]; DNA binding site 936156004987 UTRA domain; Region: UTRA; pfam07702 936156004988 Lamin Tail Domain; Region: LTD; pfam00932 936156004989 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 936156004990 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 936156004991 putative active site [active] 936156004992 putative metal binding site [ion binding]; other site 936156004993 Predicted membrane protein [Function unknown]; Region: COG1950 936156004994 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 936156004995 Uncharacterized conserved protein [Function unknown]; Region: COG3595 936156004996 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 936156004997 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 936156004998 potential frameshift: common BLAST hit: gi|16080568|ref|NP_391395.1| putative flagellin 936156004999 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 936156005000 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 936156005001 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 936156005002 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 936156005003 excinuclease ABC subunit B; Provisional; Region: PRK05298 936156005004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936156005005 ATP binding site [chemical binding]; other site 936156005006 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156005007 nucleotide binding region [chemical binding]; other site 936156005008 ATP-binding site [chemical binding]; other site 936156005009 Ultra-violet resistance protein B; Region: UvrB; pfam12344 936156005010 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 936156005011 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 936156005012 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 936156005013 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 936156005014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156005015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156005016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156005017 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156005018 putative substrate translocation pore; other site 936156005019 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 936156005020 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 936156005021 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 936156005022 C-terminal peptidase (prc); Region: prc; TIGR00225 936156005023 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 936156005024 protein binding site [polypeptide binding]; other site 936156005025 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 936156005026 Catalytic dyad [active] 936156005027 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 936156005028 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 936156005029 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 936156005030 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 936156005031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936156005032 Walker A/P-loop; other site 936156005033 ATP binding site [chemical binding]; other site 936156005034 Q-loop/lid; other site 936156005035 ABC transporter signature motif; other site 936156005036 Walker B; other site 936156005037 D-loop; other site 936156005038 H-loop/switch region; other site 936156005039 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 936156005040 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 936156005041 Uncharacterized conserved protein [Function unknown]; Region: COG1284 936156005042 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156005043 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156005044 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 936156005045 peptide chain release factor 2; Provisional; Region: PRK06746 936156005046 This domain is found in peptide chain release factors; Region: PCRF; smart00937 936156005047 RF-1 domain; Region: RF-1; pfam00472 936156005048 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 936156005049 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 936156005050 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 936156005051 nucleotide binding region [chemical binding]; other site 936156005052 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 936156005053 ATP-binding site [chemical binding]; other site 936156005054 SEC-C motif; Region: SEC-C; pfam02810 936156005055 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 936156005056 30S subunit binding site; other site 936156005057 Flagellar protein FliT; Region: FliT; pfam05400 936156005058 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 936156005059 flagellar capping protein; Validated; Region: fliD; PRK07737 936156005060 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 936156005061 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 936156005062 flagellar protein FlaG; Provisional; Region: PRK07738 936156005063 flagellin; Provisional; Region: PRK12804 936156005064 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 936156005065 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 936156005066 carbon storage regulator; Provisional; Region: PRK01712 936156005067 flagellar assembly protein FliW; Provisional; Region: PRK13285 936156005068 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 936156005069 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 936156005070 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 936156005071 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 936156005072 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 936156005073 FlgN protein; Region: FlgN; pfam05130 936156005074 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 936156005075 flagellar operon protein TIGR03826; Region: YvyF 936156005076 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936156005077 active site 936156005078 Late competence development protein ComFB; Region: ComFB; pfam10719 936156005079 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 936156005080 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936156005081 ATP binding site [chemical binding]; other site 936156005082 putative Mg++ binding site [ion binding]; other site 936156005083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156005084 nucleotide binding region [chemical binding]; other site 936156005085 ATP-binding site [chemical binding]; other site 936156005086 EDD domain protein, DegV family; Region: DegV; TIGR00762 936156005087 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 936156005088 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936156005089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156005090 active site 936156005091 phosphorylation site [posttranslational modification] 936156005092 intermolecular recognition site; other site 936156005093 dimerization interface [polypeptide binding]; other site 936156005094 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936156005095 DNA binding residues [nucleotide binding] 936156005096 dimerization interface [polypeptide binding]; other site 936156005097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 936156005098 Histidine kinase; Region: HisKA_3; pfam07730 936156005099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156005100 ATP binding site [chemical binding]; other site 936156005101 Mg2+ binding site [ion binding]; other site 936156005102 G-X-G motif; other site 936156005103 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 936156005104 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 936156005105 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 936156005106 Transcriptional regulator [Transcription]; Region: LytR; COG1316 936156005107 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 936156005108 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 936156005109 Mg++ binding site [ion binding]; other site 936156005110 putative catalytic motif [active] 936156005111 substrate binding site [chemical binding]; other site 936156005112 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 936156005113 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936156005114 putative homodimer interface [polypeptide binding]; other site 936156005115 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 936156005116 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 936156005117 active site 936156005118 Chain length determinant protein; Region: Wzz; cl15801 936156005119 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 936156005120 O-Antigen ligase; Region: Wzy_C; pfam04932 936156005121 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 936156005122 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 936156005123 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 936156005124 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 936156005125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936156005126 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 936156005127 colanic acid exporter; Provisional; Region: PRK10459 936156005128 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 936156005129 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 936156005130 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 936156005131 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 936156005132 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 936156005133 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 936156005134 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 936156005135 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 936156005136 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 936156005137 active site 936156005138 metal binding site [ion binding]; metal-binding site 936156005139 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 936156005140 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 936156005141 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 936156005142 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 936156005143 Stage II sporulation protein; Region: SpoIID; pfam08486 936156005144 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 936156005145 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 936156005146 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 936156005147 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 936156005148 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 936156005149 active site 936156005150 homodimer interface [polypeptide binding]; other site 936156005151 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 936156005152 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 936156005153 active site 936156005154 tetramer interface; other site 936156005155 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 936156005156 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 936156005157 Walker A/P-loop; other site 936156005158 ATP binding site [chemical binding]; other site 936156005159 Q-loop/lid; other site 936156005160 ABC transporter signature motif; other site 936156005161 Walker B; other site 936156005162 D-loop; other site 936156005163 H-loop/switch region; other site 936156005164 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 936156005165 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 936156005166 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 936156005167 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 936156005168 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 936156005169 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 936156005170 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936156005171 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 936156005172 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 936156005173 active site 936156005174 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 936156005175 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 936156005176 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 936156005177 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 936156005178 potential frameshift: common BLAST hit: gi|16080630|ref|NP_391458.1| putative polyglycerol phosphate assembly and export protein 936156005179 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 936156005180 Bacterial SH3 domain; Region: SH3_3; pfam08239 936156005181 Lysozyme subfamily 2; Region: LYZ2; smart00047 936156005182 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 936156005183 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 936156005184 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 936156005185 Spore germination protein; Region: Spore_permease; pfam03845 936156005186 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 936156005187 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 936156005188 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 936156005189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156005190 putative substrate translocation pore; other site 936156005191 Transcriptional regulator [Transcription]; Region: LytR; COG1316 936156005192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156005193 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 936156005194 active site 936156005195 motif I; other site 936156005196 motif II; other site 936156005197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156005198 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 936156005199 NlpC/P60 family; Region: NLPC_P60; pfam00877 936156005200 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 936156005201 NlpC/P60 family; Region: NLPC_P60; pfam00877 936156005202 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 936156005203 NlpC/P60 family; Region: NLPC_P60; pfam00877 936156005204 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 936156005205 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 936156005206 putative active site [active] 936156005207 putative metal binding site [ion binding]; other site 936156005208 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 936156005209 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 936156005210 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936156005211 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936156005212 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936156005213 DNA binding site [nucleotide binding] 936156005214 domain linker motif; other site 936156005215 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 936156005216 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936156005217 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 936156005218 substrate binding site [chemical binding]; other site 936156005219 dimer interface [polypeptide binding]; other site 936156005220 ATP binding site [chemical binding]; other site 936156005221 D-ribose pyranase; Provisional; Region: PRK11797 936156005222 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 936156005223 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 936156005224 Walker A/P-loop; other site 936156005225 ATP binding site [chemical binding]; other site 936156005226 Q-loop/lid; other site 936156005227 ABC transporter signature motif; other site 936156005228 Walker B; other site 936156005229 D-loop; other site 936156005230 H-loop/switch region; other site 936156005231 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 936156005232 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 936156005233 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 936156005234 TM-ABC transporter signature motif; other site 936156005235 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 936156005236 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 936156005237 ligand binding site [chemical binding]; other site 936156005238 dimerization interface [polypeptide binding]; other site 936156005239 Bacterial SH3 domain homologues; Region: SH3b; smart00287 936156005240 Bacterial SH3 domain; Region: SH3_3; cl17532 936156005241 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 936156005242 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 936156005243 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 936156005244 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 936156005245 acetolactate synthase; Reviewed; Region: PRK08617 936156005246 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 936156005247 PYR/PP interface [polypeptide binding]; other site 936156005248 dimer interface [polypeptide binding]; other site 936156005249 TPP binding site [chemical binding]; other site 936156005250 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 936156005251 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 936156005252 TPP-binding site [chemical binding]; other site 936156005253 dimer interface [polypeptide binding]; other site 936156005254 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 936156005255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156005256 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 936156005257 putative dimerization interface [polypeptide binding]; other site 936156005258 putative substrate binding pocket [chemical binding]; other site 936156005259 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 936156005260 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 936156005261 transmembrane helices; other site 936156005262 CotH protein; Region: CotH; pfam08757 936156005263 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 936156005264 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 936156005265 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 936156005266 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 936156005267 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 936156005268 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156005269 putative DNA binding site [nucleotide binding]; other site 936156005270 putative Zn2+ binding site [ion binding]; other site 936156005271 AsnC family; Region: AsnC_trans_reg; pfam01037 936156005272 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 936156005273 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 936156005274 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 936156005275 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 936156005276 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156005277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156005278 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936156005279 dimerization interface [polypeptide binding]; other site 936156005280 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 936156005281 Active_site [active] 936156005282 LXG domain of WXG superfamily; Region: LXG; pfam04740 936156005283 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 936156005284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 936156005285 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 936156005286 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 936156005287 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 936156005288 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 936156005289 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 936156005290 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 936156005291 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 936156005292 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 936156005293 Chain length determinant protein; Region: Wzz; cl15801 936156005294 SWIM zinc finger; Region: SWIM; pfam04434 936156005295 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 936156005296 SNF2 Helicase protein; Region: DUF3670; pfam12419 936156005297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936156005298 ATP binding site [chemical binding]; other site 936156005299 putative Mg++ binding site [ion binding]; other site 936156005300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156005301 nucleotide binding region [chemical binding]; other site 936156005302 ATP-binding site [chemical binding]; other site 936156005303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156005304 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 936156005305 active site 936156005306 motif I; other site 936156005307 motif II; other site 936156005308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156005309 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936156005310 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 936156005311 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936156005312 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 936156005313 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 936156005314 dimer interface [polypeptide binding]; other site 936156005315 ssDNA binding site [nucleotide binding]; other site 936156005316 tetramer (dimer of dimers) interface [polypeptide binding]; other site 936156005317 YwpF-like protein; Region: YwpF; pfam14183 936156005318 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 936156005319 active site 936156005320 catalytic site [active] 936156005321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936156005322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156005323 intermolecular recognition site; other site 936156005324 active site 936156005325 dimerization interface [polypeptide binding]; other site 936156005326 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 936156005327 Histidine kinase; Region: His_kinase; pfam06580 936156005328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156005329 ATP binding site [chemical binding]; other site 936156005330 Mg2+ binding site [ion binding]; other site 936156005331 G-X-G motif; other site 936156005332 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 936156005333 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 936156005334 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 936156005335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156005336 binding surface 936156005337 TPR motif; other site 936156005338 Tetratricopeptide repeat; Region: TPR_16; pfam13432 936156005339 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 936156005340 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 936156005341 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 936156005342 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 936156005343 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 936156005344 rod shape-determining protein Mbl; Provisional; Region: PRK13928 936156005345 MreB and similar proteins; Region: MreB_like; cd10225 936156005346 nucleotide binding site [chemical binding]; other site 936156005347 Mg binding site [ion binding]; other site 936156005348 putative protofilament interaction site [polypeptide binding]; other site 936156005349 RodZ interaction site [polypeptide binding]; other site 936156005350 Stage III sporulation protein D; Region: SpoIIID; pfam12116 936156005351 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156005352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156005353 putative Zn2+ binding site [ion binding]; other site 936156005354 putative DNA binding site [nucleotide binding]; other site 936156005355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156005356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156005357 putative substrate translocation pore; other site 936156005358 Right handed beta helix region; Region: Beta_helix; pfam13229 936156005359 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 936156005360 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 936156005361 Na binding site [ion binding]; other site 936156005362 putative substrate binding site [chemical binding]; other site 936156005363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156005364 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156005365 putative substrate translocation pore; other site 936156005366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156005367 Isochorismatase family; Region: Isochorismatase; pfam00857 936156005368 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 936156005369 catalytic triad [active] 936156005370 conserved cis-peptide bond; other site 936156005371 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 936156005372 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 936156005373 Nitrogen regulatory protein P-II; Region: P-II; smart00938 936156005374 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 936156005375 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 936156005376 active site 936156005377 VanZ like family; Region: VanZ; pfam04892 936156005378 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 936156005379 Peptidase family M23; Region: Peptidase_M23; pfam01551 936156005380 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 936156005381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156005382 Coenzyme A binding pocket [chemical binding]; other site 936156005383 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 936156005384 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 936156005385 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 936156005386 putative active site [active] 936156005387 catalytic site [active] 936156005388 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 936156005389 putative active site [active] 936156005390 catalytic site [active] 936156005391 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 936156005392 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 936156005393 DNA binding residues [nucleotide binding] 936156005394 dimer interface [polypeptide binding]; other site 936156005395 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 936156005396 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 936156005397 NADH(P)-binding; Region: NAD_binding_10; pfam13460 936156005398 NAD binding site [chemical binding]; other site 936156005399 substrate binding site [chemical binding]; other site 936156005400 putative active site [active] 936156005401 Predicted transcriptional regulator [Transcription]; Region: COG1959 936156005402 Transcriptional regulator; Region: Rrf2; pfam02082 936156005403 urease subunit alpha; Reviewed; Region: ureC; PRK13207 936156005404 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 936156005405 subunit interactions [polypeptide binding]; other site 936156005406 active site 936156005407 flap region; other site 936156005408 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 936156005409 gamma-beta subunit interface [polypeptide binding]; other site 936156005410 alpha-beta subunit interface [polypeptide binding]; other site 936156005411 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 936156005412 alpha-gamma subunit interface [polypeptide binding]; other site 936156005413 beta-gamma subunit interface [polypeptide binding]; other site 936156005414 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 936156005415 CsbD-like; Region: CsbD; pfam05532 936156005416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156005417 binding surface 936156005418 TPR motif; other site 936156005419 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156005420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156005421 binding surface 936156005422 TPR motif; other site 936156005423 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 936156005424 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936156005425 FeS/SAM binding site; other site 936156005426 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 936156005427 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 936156005428 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 936156005429 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 936156005430 metal ion-dependent adhesion site (MIDAS); other site 936156005431 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 936156005432 metal ion-dependent adhesion site (MIDAS); other site 936156005433 stage II sporulation protein D; Region: spore_II_D; TIGR02870 936156005434 Stage II sporulation protein; Region: SpoIID; pfam08486 936156005435 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 936156005436 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 936156005437 hinge; other site 936156005438 active site 936156005439 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 936156005440 Predicted membrane protein [Function unknown]; Region: COG4836 936156005441 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 936156005442 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 936156005443 gamma subunit interface [polypeptide binding]; other site 936156005444 epsilon subunit interface [polypeptide binding]; other site 936156005445 LBP interface [polypeptide binding]; other site 936156005446 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 936156005447 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 936156005448 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 936156005449 alpha subunit interaction interface [polypeptide binding]; other site 936156005450 Walker A motif; other site 936156005451 ATP binding site [chemical binding]; other site 936156005452 Walker B motif; other site 936156005453 inhibitor binding site; inhibition site 936156005454 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 936156005455 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 936156005456 core domain interface [polypeptide binding]; other site 936156005457 delta subunit interface [polypeptide binding]; other site 936156005458 epsilon subunit interface [polypeptide binding]; other site 936156005459 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 936156005460 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 936156005461 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 936156005462 beta subunit interaction interface [polypeptide binding]; other site 936156005463 Walker A motif; other site 936156005464 ATP binding site [chemical binding]; other site 936156005465 Walker B motif; other site 936156005466 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 936156005467 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 936156005468 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 936156005469 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 936156005470 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 936156005471 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 936156005472 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 936156005473 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 936156005474 ATP synthase I chain; Region: ATP_synt_I; pfam03899 936156005475 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936156005476 active site 936156005477 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 936156005478 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 936156005479 dimer interface [polypeptide binding]; other site 936156005480 active site 936156005481 glycine-pyridoxal phosphate binding site [chemical binding]; other site 936156005482 folate binding site [chemical binding]; other site 936156005483 hypothetical protein; Provisional; Region: PRK13690 936156005484 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 936156005485 Low molecular weight phosphatase family; Region: LMWPc; cd00115 936156005486 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 936156005487 active site 936156005488 Predicted membrane protein [Function unknown]; Region: COG1971 936156005489 Domain of unknown function DUF; Region: DUF204; pfam02659 936156005490 Domain of unknown function DUF; Region: DUF204; pfam02659 936156005491 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 936156005492 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 936156005493 N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246 936156005494 stage II sporulation protein R; Region: spore_II_R; TIGR02837 936156005495 HemK family putative methylases; Region: hemK_fam; TIGR00536 936156005496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156005497 S-adenosylmethionine binding site [chemical binding]; other site 936156005498 peptide chain release factor 1; Validated; Region: prfA; PRK00591 936156005499 This domain is found in peptide chain release factors; Region: PCRF; smart00937 936156005500 RF-1 domain; Region: RF-1; pfam00472 936156005501 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 936156005502 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156005503 putative metal binding site [ion binding]; other site 936156005504 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 936156005505 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 936156005506 DNA binding residues [nucleotide binding] 936156005507 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 936156005508 malate dehydrogenase; Provisional; Region: PRK13529 936156005509 Malic enzyme, N-terminal domain; Region: malic; pfam00390 936156005510 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 936156005511 NAD(P) binding site [chemical binding]; other site 936156005512 thymidine kinase; Provisional; Region: PRK04296 936156005513 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 936156005514 transcription termination factor Rho; Provisional; Region: rho; PRK09376 936156005515 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 936156005516 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 936156005517 RNA binding site [nucleotide binding]; other site 936156005518 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 936156005519 multimer interface [polypeptide binding]; other site 936156005520 Walker A motif; other site 936156005521 ATP binding site [chemical binding]; other site 936156005522 Walker B motif; other site 936156005523 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 936156005524 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 936156005525 putative active site [active] 936156005526 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 936156005527 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 936156005528 hinge; other site 936156005529 active site 936156005530 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 936156005531 active site 936156005532 intersubunit interactions; other site 936156005533 catalytic residue [active] 936156005534 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 936156005535 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 936156005536 intersubunit interface [polypeptide binding]; other site 936156005537 active site 936156005538 zinc binding site [ion binding]; other site 936156005539 Na+ binding site [ion binding]; other site 936156005540 Response regulator receiver domain; Region: Response_reg; pfam00072 936156005541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156005542 active site 936156005543 phosphorylation site [posttranslational modification] 936156005544 intermolecular recognition site; other site 936156005545 dimerization interface [polypeptide binding]; other site 936156005546 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 936156005547 CTP synthetase; Validated; Region: pyrG; PRK05380 936156005548 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 936156005549 Catalytic site [active] 936156005550 active site 936156005551 UTP binding site [chemical binding]; other site 936156005552 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 936156005553 active site 936156005554 putative oxyanion hole; other site 936156005555 catalytic triad [active] 936156005556 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 936156005557 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 936156005558 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 936156005559 FAD binding site [chemical binding]; other site 936156005560 homotetramer interface [polypeptide binding]; other site 936156005561 substrate binding pocket [chemical binding]; other site 936156005562 catalytic base [active] 936156005563 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 936156005564 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 936156005565 Cysteine-rich domain; Region: CCG; pfam02754 936156005566 Cysteine-rich domain; Region: CCG; pfam02754 936156005567 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 936156005568 putative active site [active] 936156005569 catalytic site [active] 936156005570 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 936156005571 PLD-like domain; Region: PLDc_2; pfam13091 936156005572 putative active site [active] 936156005573 catalytic site [active] 936156005574 UV-endonuclease UvdE; Region: UvdE; cl10036 936156005575 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 936156005576 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 936156005577 folate binding site [chemical binding]; other site 936156005578 NADP+ binding site [chemical binding]; other site 936156005579 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 936156005580 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936156005581 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 936156005582 Walker A/P-loop; other site 936156005583 ATP binding site [chemical binding]; other site 936156005584 Q-loop/lid; other site 936156005585 ABC transporter signature motif; other site 936156005586 Walker B; other site 936156005587 D-loop; other site 936156005588 H-loop/switch region; other site 936156005589 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 936156005590 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 936156005591 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 936156005592 putative active site [active] 936156005593 catalytic site [active] 936156005594 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 936156005595 putative active site [active] 936156005596 catalytic site [active] 936156005597 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 936156005598 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 936156005599 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 936156005600 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 936156005601 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 936156005602 [4Fe-4S] binding site [ion binding]; other site 936156005603 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936156005604 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936156005605 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936156005606 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 936156005607 molybdopterin cofactor binding site; other site 936156005608 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 936156005609 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 936156005610 ligand binding site [chemical binding]; other site 936156005611 flexible hinge region; other site 936156005612 YwiC-like protein; Region: YwiC; pfam14256 936156005613 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 936156005614 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 936156005615 ligand binding site [chemical binding]; other site 936156005616 flexible hinge region; other site 936156005617 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 936156005618 putative switch regulator; other site 936156005619 non-specific DNA interactions [nucleotide binding]; other site 936156005620 DNA binding site [nucleotide binding] 936156005621 sequence specific DNA binding site [nucleotide binding]; other site 936156005622 putative cAMP binding site [chemical binding]; other site 936156005623 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 936156005624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156005625 putative substrate translocation pore; other site 936156005626 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 936156005627 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 936156005628 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 936156005629 active site 936156005630 HIGH motif; other site 936156005631 KMSK motif region; other site 936156005632 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 936156005633 tRNA binding surface [nucleotide binding]; other site 936156005634 anticodon binding site; other site 936156005635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 936156005636 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 936156005637 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 936156005638 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 936156005639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936156005640 FeS/SAM binding site; other site 936156005641 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 936156005642 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 936156005643 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 936156005644 Walker A/P-loop; other site 936156005645 ATP binding site [chemical binding]; other site 936156005646 Q-loop/lid; other site 936156005647 ABC transporter signature motif; other site 936156005648 Walker B; other site 936156005649 D-loop; other site 936156005650 H-loop/switch region; other site 936156005651 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 936156005652 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 936156005653 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 936156005654 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 936156005655 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 936156005656 Uncharacterized conserved protein [Function unknown]; Region: COG3391 936156005657 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 936156005658 Uncharacterized conserved protein [Function unknown]; Region: COG3391 936156005659 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 936156005660 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156005661 TPR motif; other site 936156005662 binding surface 936156005663 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156005664 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 936156005665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936156005666 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 936156005667 Walker A/P-loop; other site 936156005668 ATP binding site [chemical binding]; other site 936156005669 Q-loop/lid; other site 936156005670 ABC transporter signature motif; other site 936156005671 Walker B; other site 936156005672 D-loop; other site 936156005673 H-loop/switch region; other site 936156005674 agmatinase; Region: agmatinase; TIGR01230 936156005675 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 936156005676 putative active site [active] 936156005677 Mn binding site [ion binding]; other site 936156005678 spermidine synthase; Provisional; Region: PRK00811 936156005679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156005680 Transglycosylase; Region: Transgly; pfam00912 936156005681 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 936156005682 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 936156005683 YwhD family; Region: YwhD; pfam08741 936156005684 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 936156005685 Peptidase family M50; Region: Peptidase_M50; pfam02163 936156005686 active site 936156005687 putative substrate binding region [chemical binding]; other site 936156005688 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 936156005689 active site 1 [active] 936156005690 dimer interface [polypeptide binding]; other site 936156005691 hexamer interface [polypeptide binding]; other site 936156005692 active site 2 [active] 936156005693 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156005694 MarR family; Region: MarR; pfam01047 936156005695 MarR family; Region: MarR_2; cl17246 936156005696 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 936156005697 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 936156005698 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 936156005699 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 936156005700 active site 936156005701 dimer interface [polypeptide binding]; other site 936156005702 motif 1; other site 936156005703 motif 2; other site 936156005704 motif 3; other site 936156005705 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 936156005706 anticodon binding site; other site 936156005707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156005708 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156005709 putative substrate translocation pore; other site 936156005710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156005711 putative substrate translocation pore; other site 936156005712 Rrf2 family protein; Region: rrf2_super; TIGR00738 936156005713 Transcriptional regulator; Region: Rrf2; pfam02082 936156005714 Uncharacterized conserved protein [Function unknown]; Region: COG3465 936156005715 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 936156005716 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936156005717 Zn2+ binding site [ion binding]; other site 936156005718 Mg2+ binding site [ion binding]; other site 936156005719 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 936156005720 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 936156005721 EamA-like transporter family; Region: EamA; pfam00892 936156005722 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 936156005723 EamA-like transporter family; Region: EamA; pfam00892 936156005724 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 936156005725 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156005726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156005727 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 936156005728 putative dimerization interface [polypeptide binding]; other site 936156005729 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 936156005730 putative heme peroxidase; Provisional; Region: PRK12276 936156005731 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 936156005732 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 936156005733 putative NAD(P) binding site [chemical binding]; other site 936156005734 putative active site [active] 936156005735 transaminase; Reviewed; Region: PRK08068 936156005736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156005737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156005738 homodimer interface [polypeptide binding]; other site 936156005739 catalytic residue [active] 936156005740 H+ Antiporter protein; Region: 2A0121; TIGR00900 936156005741 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 936156005742 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 936156005743 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 936156005744 classical (c) SDRs; Region: SDR_c; cd05233 936156005745 NAD(P) binding site [chemical binding]; other site 936156005746 active site 936156005747 Cupin domain; Region: Cupin_2; pfam07883 936156005748 Cupin domain; Region: Cupin_2; pfam07883 936156005749 Prephenate dehydratase; Region: PDT; pfam00800 936156005750 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936156005751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156005752 putative substrate translocation pore; other site 936156005753 S-methylmethionine transporter; Provisional; Region: PRK11387 936156005754 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 936156005755 putative metal binding site [ion binding]; other site 936156005756 putative dimer interface [polypeptide binding]; other site 936156005757 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 936156005758 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 936156005759 Glutamate binding site [chemical binding]; other site 936156005760 homodimer interface [polypeptide binding]; other site 936156005761 NAD binding site [chemical binding]; other site 936156005762 catalytic residues [active] 936156005763 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 936156005764 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 936156005765 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 936156005766 NAD(P) binding site [chemical binding]; other site 936156005767 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 936156005768 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 936156005769 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 936156005770 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 936156005771 NADP binding site [chemical binding]; other site 936156005772 active site 936156005773 putative substrate binding site [chemical binding]; other site 936156005774 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 936156005775 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 936156005776 NAD binding site [chemical binding]; other site 936156005777 substrate binding site [chemical binding]; other site 936156005778 homodimer interface [polypeptide binding]; other site 936156005779 active site 936156005780 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 936156005781 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 936156005782 substrate binding site; other site 936156005783 tetramer interface; other site 936156005784 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 936156005785 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 936156005786 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 936156005787 ligand binding site; other site 936156005788 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 936156005789 NeuB family; Region: NeuB; pfam03102 936156005790 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 936156005791 NeuB binding interface [polypeptide binding]; other site 936156005792 putative substrate binding site [chemical binding]; other site 936156005793 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 936156005794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156005795 Coenzyme A binding pocket [chemical binding]; other site 936156005796 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 936156005797 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 936156005798 inhibitor-cofactor binding pocket; inhibition site 936156005799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156005800 catalytic residue [active] 936156005801 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 936156005802 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 936156005803 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 936156005804 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 936156005805 active site 936156005806 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 936156005807 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 936156005808 Permease family; Region: Xan_ur_permease; pfam00860 936156005809 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 936156005810 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 936156005811 NAD(P) binding site [chemical binding]; other site 936156005812 catalytic residues [active] 936156005813 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 936156005814 ligand binding site [chemical binding]; other site 936156005815 active site 936156005816 UGI interface [polypeptide binding]; other site 936156005817 catalytic site [active] 936156005818 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 936156005819 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 936156005820 active site 936156005821 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 936156005822 dimer interface [polypeptide binding]; other site 936156005823 substrate binding site [chemical binding]; other site 936156005824 ATP binding site [chemical binding]; other site 936156005825 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 936156005826 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 936156005827 substrate binding [chemical binding]; other site 936156005828 active site 936156005829 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 936156005830 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 936156005831 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 936156005832 active site turn [active] 936156005833 phosphorylation site [posttranslational modification] 936156005834 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 936156005835 formate/nitrite transporter; Region: fnt; TIGR00790 936156005836 transcriptional antiterminator BglG; Provisional; Region: PRK09772 936156005837 CAT RNA binding domain; Region: CAT_RBD; smart01061 936156005838 PRD domain; Region: PRD; pfam00874 936156005839 PRD domain; Region: PRD; pfam00874 936156005840 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 936156005841 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 936156005842 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 936156005843 putative active site [active] 936156005844 catalytic triad [active] 936156005845 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 936156005846 PA/protease domain interface [polypeptide binding]; other site 936156005847 putative integrin binding motif; other site 936156005848 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 936156005849 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 936156005850 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 936156005851 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 936156005852 Bacterial protein of unknown function (HtrL_YibB); Region: HtrL_YibB; cl08171 936156005853 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 936156005854 dimer interface [polypeptide binding]; other site 936156005855 FMN binding site [chemical binding]; other site 936156005856 NADPH bind site [chemical binding]; other site 936156005857 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 936156005858 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 936156005859 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 936156005860 Subunit I/III interface [polypeptide binding]; other site 936156005861 Subunit III/IV interface [polypeptide binding]; other site 936156005862 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 936156005863 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 936156005864 D-pathway; other site 936156005865 Putative ubiquinol binding site [chemical binding]; other site 936156005866 Low-spin heme (heme b) binding site [chemical binding]; other site 936156005867 Putative water exit pathway; other site 936156005868 Binuclear center (heme o3/CuB) [ion binding]; other site 936156005869 K-pathway; other site 936156005870 Putative proton exit pathway; other site 936156005871 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 936156005872 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 936156005873 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 936156005874 Predicted membrane protein [Function unknown]; Region: COG2261 936156005875 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 936156005876 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 936156005877 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 936156005878 galactokinase; Provisional; Region: PRK05322 936156005879 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 936156005880 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 936156005881 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 936156005882 Predicted membrane protein [Function unknown]; Region: COG2246 936156005883 GtrA-like protein; Region: GtrA; pfam04138 936156005884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156005885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156005886 Anti-repressor SinI; Region: SinI; pfam08671 936156005887 Predicted membrane protein [Function unknown]; Region: COG3162 936156005888 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 936156005889 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 936156005890 Na binding site [ion binding]; other site 936156005891 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 936156005892 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 936156005893 catalytic residues [active] 936156005894 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 936156005895 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 936156005896 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 936156005897 Imelysin; Region: Peptidase_M75; pfam09375 936156005898 FTR1 family protein; Region: TIGR00145 936156005899 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 936156005900 thiamine phosphate binding site [chemical binding]; other site 936156005901 active site 936156005902 pyrophosphate binding site [ion binding]; other site 936156005903 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 936156005904 substrate binding site [chemical binding]; other site 936156005905 multimerization interface [polypeptide binding]; other site 936156005906 ATP binding site [chemical binding]; other site 936156005907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156005908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156005909 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 936156005910 putative dimerization interface [polypeptide binding]; other site 936156005911 holin-like protein; Validated; Region: PRK01658 936156005912 TIGR00659 family protein; Region: TIGR00659 936156005913 sugar efflux transporter; Region: 2A0120; TIGR00899 936156005914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156005915 putative substrate translocation pore; other site 936156005916 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 936156005917 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 936156005918 PUA domain; Region: PUA; cl00607 936156005919 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 936156005920 putative RNA binding site [nucleotide binding]; other site 936156005921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156005922 S-adenosylmethionine binding site [chemical binding]; other site 936156005923 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156005924 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 936156005925 active site 936156005926 metal binding site [ion binding]; metal-binding site 936156005927 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 936156005928 Kelch domain; Region: Kelch; smart00612 936156005929 Kelch motif; Region: Kelch_1; pfam01344 936156005930 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 936156005931 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 936156005932 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 936156005933 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 936156005934 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 936156005935 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 936156005936 active site 936156005937 catalytic residues [active] 936156005938 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 936156005939 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 936156005940 active site turn [active] 936156005941 phosphorylation site [posttranslational modification] 936156005942 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 936156005943 transcriptional antiterminator BglG; Provisional; Region: PRK09772 936156005944 CAT RNA binding domain; Region: CAT_RBD; smart01061 936156005945 PRD domain; Region: PRD; pfam00874 936156005946 PRD domain; Region: PRD; pfam00874 936156005947 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 936156005948 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 936156005949 Ligand binding site; other site 936156005950 metal-binding site 936156005951 Predicted integral membrane protein [Function unknown]; Region: COG5522 936156005952 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156005953 MarR family; Region: MarR; pfam01047 936156005954 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 936156005955 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 936156005956 active site 936156005957 HIGH motif; other site 936156005958 dimer interface [polypeptide binding]; other site 936156005959 KMSKS motif; other site 936156005960 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936156005961 RNA binding surface [nucleotide binding]; other site 936156005962 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 936156005963 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 936156005964 PA/protease domain interface [polypeptide binding]; other site 936156005965 putative integrin binding motif; other site 936156005966 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 936156005967 Peptidase family M28; Region: Peptidase_M28; pfam04389 936156005968 metal binding site [ion binding]; metal-binding site 936156005969 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156005970 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936156005971 salt bridge; other site 936156005972 non-specific DNA binding site [nucleotide binding]; other site 936156005973 sequence-specific DNA binding site [nucleotide binding]; other site 936156005974 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 936156005975 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936156005976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156005977 putative substrate translocation pore; other site 936156005978 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 936156005979 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 936156005980 synthetase active site [active] 936156005981 NTP binding site [chemical binding]; other site 936156005982 metal binding site [ion binding]; metal-binding site 936156005983 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 936156005984 UbiA prenyltransferase family; Region: UbiA; pfam01040 936156005985 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 936156005986 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 936156005987 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 936156005988 acyl-activating enzyme (AAE) consensus motif; other site 936156005989 AMP binding site [chemical binding]; other site 936156005990 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 936156005991 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 936156005992 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 936156005993 DltD N-terminal region; Region: DltD_N; pfam04915 936156005994 DltD central region; Region: DltD_M; pfam04918 936156005995 DltD C-terminal region; Region: DltD_C; pfam04914 936156005996 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 936156005997 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 936156005998 putative NAD(P) binding site [chemical binding]; other site 936156005999 active site 936156006000 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 936156006001 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 936156006002 homodimer interface [polypeptide binding]; other site 936156006003 substrate-cofactor binding pocket; other site 936156006004 catalytic residue [active] 936156006005 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 936156006006 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 936156006007 NAD binding site [chemical binding]; other site 936156006008 sugar binding site [chemical binding]; other site 936156006009 divalent metal binding site [ion binding]; other site 936156006010 tetramer (dimer of dimers) interface [polypeptide binding]; other site 936156006011 dimer interface [polypeptide binding]; other site 936156006012 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 936156006013 methionine cluster; other site 936156006014 active site 936156006015 phosphorylation site [posttranslational modification] 936156006016 metal binding site [ion binding]; metal-binding site 936156006017 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 936156006018 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 936156006019 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 936156006020 active site 936156006021 P-loop; other site 936156006022 phosphorylation site [posttranslational modification] 936156006023 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 936156006024 HTH domain; Region: HTH_11; pfam08279 936156006025 Mga helix-turn-helix domain; Region: Mga; pfam05043 936156006026 PRD domain; Region: PRD; pfam00874 936156006027 PRD domain; Region: PRD; pfam00874 936156006028 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 936156006029 active site 936156006030 P-loop; other site 936156006031 phosphorylation site [posttranslational modification] 936156006032 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936156006033 active site 936156006034 phosphorylation site [posttranslational modification] 936156006035 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 936156006036 active site 936156006037 DNA binding site [nucleotide binding] 936156006038 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 936156006039 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 936156006040 tetramer interface [polypeptide binding]; other site 936156006041 heme binding pocket [chemical binding]; other site 936156006042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156006043 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156006044 putative substrate translocation pore; other site 936156006045 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 936156006046 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 936156006047 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 936156006048 Walker A/P-loop; other site 936156006049 ATP binding site [chemical binding]; other site 936156006050 Q-loop/lid; other site 936156006051 ABC transporter signature motif; other site 936156006052 Walker B; other site 936156006053 D-loop; other site 936156006054 H-loop/switch region; other site 936156006055 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 936156006056 Exoribonuclease II [Transcription]; Region: Rnb; COG4776 936156006057 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 936156006058 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156006059 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156006060 DNA binding residues [nucleotide binding] 936156006061 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 936156006062 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 936156006063 Na binding site [ion binding]; other site 936156006064 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 936156006065 putative substrate binding site [chemical binding]; other site 936156006066 putative ATP binding site [chemical binding]; other site 936156006067 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 936156006068 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936156006069 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 936156006070 Walker A/P-loop; other site 936156006071 ATP binding site [chemical binding]; other site 936156006072 Q-loop/lid; other site 936156006073 ABC transporter signature motif; other site 936156006074 Walker B; other site 936156006075 D-loop; other site 936156006076 H-loop/switch region; other site 936156006077 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 936156006078 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936156006079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936156006080 ATP binding site [chemical binding]; other site 936156006081 Q-loop/lid; other site 936156006082 ABC transporter signature motif; other site 936156006083 Walker B; other site 936156006084 D-loop; other site 936156006085 H-loop/switch region; other site 936156006086 cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203 936156006087 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 936156006088 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 936156006089 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 936156006090 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 936156006091 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 936156006092 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 936156006093 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 936156006094 putative active site [active] 936156006095 putative metal binding site [ion binding]; other site 936156006096 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 936156006097 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 936156006098 Walker A/P-loop; other site 936156006099 ATP binding site [chemical binding]; other site 936156006100 Q-loop/lid; other site 936156006101 ABC transporter signature motif; other site 936156006102 Walker B; other site 936156006103 D-loop; other site 936156006104 H-loop/switch region; other site 936156006105 TOBE domain; Region: TOBE; pfam03459 936156006106 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 936156006107 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 936156006108 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 936156006109 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 936156006110 NAD(P) binding site [chemical binding]; other site 936156006111 catalytic residues [active] 936156006112 Uncharacterized conserved protein [Function unknown]; Region: COG1284 936156006113 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156006114 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156006115 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 936156006116 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 936156006117 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 936156006118 UDP-glucose 4-epimerase; Region: PLN02240 936156006119 NAD binding site [chemical binding]; other site 936156006120 homodimer interface [polypeptide binding]; other site 936156006121 active site 936156006122 substrate binding site [chemical binding]; other site 936156006123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 936156006124 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 936156006125 Histidine kinase; Region: HisKA_3; pfam07730 936156006126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156006127 ATP binding site [chemical binding]; other site 936156006128 Mg2+ binding site [ion binding]; other site 936156006129 G-X-G motif; other site 936156006130 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936156006131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156006132 active site 936156006133 phosphorylation site [posttranslational modification] 936156006134 intermolecular recognition site; other site 936156006135 dimerization interface [polypeptide binding]; other site 936156006136 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936156006137 DNA binding residues [nucleotide binding] 936156006138 dimerization interface [polypeptide binding]; other site 936156006139 peptidase T; Region: peptidase-T; TIGR01882 936156006140 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 936156006141 metal binding site [ion binding]; metal-binding site 936156006142 dimer interface [polypeptide binding]; other site 936156006143 Tubby C 2; Region: Tub_2; cl02043 936156006144 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 936156006145 substrate binding site [chemical binding]; other site 936156006146 THF binding site; other site 936156006147 zinc-binding site [ion binding]; other site 936156006148 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 936156006149 substrate binding site [chemical binding]; other site 936156006150 THF binding site; other site 936156006151 zinc-binding site [ion binding]; other site 936156006152 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 936156006153 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 936156006154 NAD binding site [chemical binding]; other site 936156006155 homotetramer interface [polypeptide binding]; other site 936156006156 homodimer interface [polypeptide binding]; other site 936156006157 substrate binding site [chemical binding]; other site 936156006158 active site 936156006159 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 936156006160 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 936156006161 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 936156006162 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 936156006163 Methyltransferase domain; Region: Methyltransf_11; pfam08241 936156006164 S-adenosylmethionine binding site [chemical binding]; other site 936156006165 nucleoside transporter; Region: nupC; TIGR00804 936156006166 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 936156006167 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 936156006168 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 936156006169 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 936156006170 hydroperoxidase II; Provisional; Region: katE; PRK11249 936156006171 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 936156006172 tetramer interface [polypeptide binding]; other site 936156006173 heme binding pocket [chemical binding]; other site 936156006174 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 936156006175 domain interactions; other site 936156006176 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 936156006177 Citrate transporter; Region: CitMHS; pfam03600 936156006178 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 936156006179 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 936156006180 active site 936156006181 active site 936156006182 catalytic residues [active] 936156006183 transcriptional antiterminator BglG; Provisional; Region: PRK09772 936156006184 CAT RNA binding domain; Region: CAT_RBD; pfam03123 936156006185 PRD domain; Region: PRD; pfam00874 936156006186 PRD domain; Region: PRD; pfam00874 936156006187 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 936156006188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156006189 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 936156006190 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 936156006191 ATP binding site [chemical binding]; other site 936156006192 Mg++ binding site [ion binding]; other site 936156006193 motif III; other site 936156006194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156006195 nucleotide binding region [chemical binding]; other site 936156006196 ATP-binding site [chemical binding]; other site 936156006197 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 936156006198 RNA binding site [nucleotide binding]; other site 936156006199 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 936156006200 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 936156006201 active site 936156006202 catalytic triad [active] 936156006203 YxiJ-like protein; Region: YxiJ; pfam14176 936156006204 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 936156006205 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 936156006206 RHS Repeat; Region: RHS_repeat; pfam05593 936156006207 RHS Repeat; Region: RHS_repeat; pfam05593 936156006208 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 936156006209 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 936156006210 RHS Repeat; Region: RHS_repeat; pfam05593 936156006211 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 936156006212 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 936156006213 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 936156006214 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 936156006215 EamA-like transporter family; Region: EamA; pfam00892 936156006216 EamA-like transporter family; Region: EamA; pfam00892 936156006217 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 936156006218 Ligand Binding Site [chemical binding]; other site 936156006219 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 936156006220 beta-galactosidase; Region: BGL; TIGR03356 936156006221 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 936156006222 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 936156006223 active site turn [active] 936156006224 phosphorylation site [posttranslational modification] 936156006225 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 936156006226 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 936156006227 HPr interaction site; other site 936156006228 glycerol kinase (GK) interaction site [polypeptide binding]; other site 936156006229 active site 936156006230 phosphorylation site [posttranslational modification] 936156006231 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 936156006232 Uncharacterized conserved protein [Function unknown]; Region: COG5444 936156006233 LXG domain of WXG superfamily; Region: LXG; pfam04740 936156006234 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 936156006235 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 936156006236 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 936156006237 substrate binding site [chemical binding]; other site 936156006238 active site 936156006239 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 936156006240 hexamer interface [polypeptide binding]; other site 936156006241 RNA binding site [nucleotide binding]; other site 936156006242 Histidine-zinc binding site [chemical binding]; other site 936156006243 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 936156006244 active sites [active] 936156006245 tetramer interface [polypeptide binding]; other site 936156006246 urocanate hydratase; Provisional; Region: PRK05414 936156006247 imidazolonepropionase; Validated; Region: PRK09356 936156006248 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 936156006249 active site 936156006250 Agmatinase-like family; Region: Agmatinase-like; cd09990 936156006251 agmatinase; Region: agmatinase; TIGR01230 936156006252 active site 936156006253 oligomer interface [polypeptide binding]; other site 936156006254 Mn binding site [ion binding]; other site 936156006255 S-methylmethionine transporter; Provisional; Region: PRK11387 936156006256 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 936156006257 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 936156006258 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 936156006259 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 936156006260 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 936156006261 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 936156006262 Nucleoside recognition; Region: Gate; pfam07670 936156006263 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 936156006264 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 936156006265 intersubunit interface [polypeptide binding]; other site 936156006266 active site 936156006267 catalytic residue [active] 936156006268 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 936156006269 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156006270 DNA binding residues [nucleotide binding] 936156006271 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 936156006272 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 936156006273 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 936156006274 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 936156006275 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 936156006276 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 936156006277 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 936156006278 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 936156006279 metal binding site [ion binding]; metal-binding site 936156006280 dimer interface [polypeptide binding]; other site 936156006281 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 936156006282 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 936156006283 Walker A/P-loop; other site 936156006284 ATP binding site [chemical binding]; other site 936156006285 Q-loop/lid; other site 936156006286 ABC transporter signature motif; other site 936156006287 Walker B; other site 936156006288 D-loop; other site 936156006289 H-loop/switch region; other site 936156006290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156006291 dimer interface [polypeptide binding]; other site 936156006292 conserved gate region; other site 936156006293 putative PBP binding loops; other site 936156006294 ABC-ATPase subunit interface; other site 936156006295 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 936156006296 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936156006297 substrate binding pocket [chemical binding]; other site 936156006298 membrane-bound complex binding site; other site 936156006299 hinge residues; other site 936156006300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156006301 Coenzyme A binding pocket [chemical binding]; other site 936156006302 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 936156006303 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 936156006304 active site 936156006305 non-prolyl cis peptide bond; other site 936156006306 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 936156006307 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 936156006308 active site 936156006309 sugar phosphate phosphatase; Provisional; Region: PRK10513 936156006310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156006311 active site 936156006312 motif I; other site 936156006313 motif II; other site 936156006314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156006315 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 936156006316 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 936156006317 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 936156006318 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 936156006319 putative ligand binding residues [chemical binding]; other site 936156006320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 936156006321 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 936156006322 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 936156006323 Walker A/P-loop; other site 936156006324 ATP binding site [chemical binding]; other site 936156006325 Q-loop/lid; other site 936156006326 ABC transporter signature motif; other site 936156006327 Walker B; other site 936156006328 D-loop; other site 936156006329 H-loop/switch region; other site 936156006330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936156006331 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 936156006332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156006333 ATP binding site [chemical binding]; other site 936156006334 Mg2+ binding site [ion binding]; other site 936156006335 G-X-G motif; other site 936156006336 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936156006337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156006338 active site 936156006339 phosphorylation site [posttranslational modification] 936156006340 intermolecular recognition site; other site 936156006341 dimerization interface [polypeptide binding]; other site 936156006342 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936156006343 DNA binding site [nucleotide binding] 936156006344 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 936156006345 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 936156006346 intersubunit interface [polypeptide binding]; other site 936156006347 active site 936156006348 zinc binding site [ion binding]; other site 936156006349 Na+ binding site [ion binding]; other site 936156006350 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 936156006351 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 936156006352 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 936156006353 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 936156006354 DNA interaction; other site 936156006355 Metal-binding active site; metal-binding site 936156006356 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 936156006357 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936156006358 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 936156006359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156006360 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156006361 putative substrate translocation pore; other site 936156006362 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 936156006363 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 936156006364 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 936156006365 PYR/PP interface [polypeptide binding]; other site 936156006366 dimer interface [polypeptide binding]; other site 936156006367 TPP binding site [chemical binding]; other site 936156006368 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 936156006369 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 936156006370 TPP-binding site; other site 936156006371 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936156006372 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 936156006373 substrate binding site [chemical binding]; other site 936156006374 ATP binding site [chemical binding]; other site 936156006375 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 936156006376 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 936156006377 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 936156006378 tetrameric interface [polypeptide binding]; other site 936156006379 NAD binding site [chemical binding]; other site 936156006380 catalytic residues [active] 936156006381 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936156006382 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 936156006383 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936156006384 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936156006385 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936156006386 active site 936156006387 catalytic tetrad [active] 936156006388 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 936156006389 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 936156006390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156006391 putative substrate translocation pore; other site 936156006392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156006393 heat shock protein 90; Provisional; Region: PRK05218 936156006394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156006395 ATP binding site [chemical binding]; other site 936156006396 Mg2+ binding site [ion binding]; other site 936156006397 G-X-G motif; other site 936156006398 short chain dehydrogenase; Validated; Region: PRK08589 936156006399 classical (c) SDRs; Region: SDR_c; cd05233 936156006400 NAD(P) binding site [chemical binding]; other site 936156006401 active site 936156006402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156006403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156006404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156006405 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 936156006406 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 936156006407 NAD(P) binding site [chemical binding]; other site 936156006408 catalytic residues [active] 936156006409 RDD family; Region: RDD; pfam06271 936156006410 FOG: WD40-like repeat [Function unknown]; Region: COG1520 936156006411 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 936156006412 active site 936156006413 Trp docking motif [polypeptide binding]; other site 936156006414 RDD family; Region: RDD; pfam06271 936156006415 Predicted membrane protein [Function unknown]; Region: COG2311 936156006416 Protein of unknown function (DUF418); Region: DUF418; pfam04235 936156006417 Cupin domain; Region: Cupin_2; pfam07883 936156006418 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 936156006419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156006420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156006421 short chain dehydrogenase; Provisional; Region: PRK07109 936156006422 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 936156006423 putative NAD(P) binding site [chemical binding]; other site 936156006424 active site 936156006425 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156006426 MarR family; Region: MarR; pfam01047 936156006427 LrgA family; Region: LrgA; cl00608 936156006428 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 936156006429 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 936156006430 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 936156006431 Glycerate kinase family; Region: Gly_kinase; pfam02595 936156006432 Transcriptional regulators [Transcription]; Region: GntR; COG1802 936156006433 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156006434 DNA-binding site [nucleotide binding]; DNA binding site 936156006435 FCD domain; Region: FCD; pfam07729 936156006436 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 936156006437 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 936156006438 N- and C-terminal domain interface [polypeptide binding]; other site 936156006439 active site 936156006440 catalytic site [active] 936156006441 metal binding site [ion binding]; metal-binding site 936156006442 carbohydrate binding site [chemical binding]; other site 936156006443 ATP binding site [chemical binding]; other site 936156006444 fructuronate transporter; Provisional; Region: PRK10034; cl15264 936156006445 gluconate transporter; Region: gntP; TIGR00791 936156006446 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 936156006447 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 936156006448 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 936156006449 peroxiredoxin; Region: AhpC; TIGR03137 936156006450 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 936156006451 dimer interface [polypeptide binding]; other site 936156006452 decamer (pentamer of dimers) interface [polypeptide binding]; other site 936156006453 catalytic triad [active] 936156006454 peroxidatic and resolving cysteines [active] 936156006455 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 936156006456 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 936156006457 catalytic residue [active] 936156006458 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 936156006459 catalytic residues [active] 936156006460 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936156006461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936156006462 potential frameshift: common BLAST hit: gi|154688098|ref|YP_001423259.1| YdgF 936156006463 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 936156006464 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 936156006465 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 936156006466 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 936156006467 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 936156006468 potential frameshift: common BLAST hit: gi|16081077|ref|NP_391905.1| putative dehydrogenase 936156006469 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 936156006470 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 936156006471 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 936156006472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156006473 Coenzyme A binding pocket [chemical binding]; other site 936156006474 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156006475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156006476 binding surface 936156006477 TPR motif; other site 936156006478 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156006479 Arginase family; Region: Arginase; cd09989 936156006480 agmatinase; Region: agmatinase; TIGR01230 936156006481 active site 936156006482 Mn binding site [ion binding]; other site 936156006483 oligomer interface [polypeptide binding]; other site 936156006484 S-methylmethionine transporter; Provisional; Region: PRK11387 936156006485 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 936156006486 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936156006487 inhibitor-cofactor binding pocket; inhibition site 936156006488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156006489 catalytic residue [active] 936156006490 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 936156006491 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 936156006492 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 936156006493 Predicted integral membrane protein [Function unknown]; Region: COG5658 936156006494 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 936156006495 SdpI/YhfL protein family; Region: SdpI; pfam13630 936156006496 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156006497 dimerization interface [polypeptide binding]; other site 936156006498 putative DNA binding site [nucleotide binding]; other site 936156006499 putative Zn2+ binding site [ion binding]; other site 936156006500 PAS domain; Region: PAS; smart00091 936156006501 PAS domain; Region: PAS_9; pfam13426 936156006502 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 936156006503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156006504 Walker A motif; other site 936156006505 ATP binding site [chemical binding]; other site 936156006506 Walker B motif; other site 936156006507 arginine finger; other site 936156006508 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 936156006509 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 936156006510 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 936156006511 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 936156006512 protein binding site [polypeptide binding]; other site 936156006513 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 936156006514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 936156006515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 936156006516 YycH protein; Region: YycH; pfam07435 936156006517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 936156006518 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936156006519 dimerization interface [polypeptide binding]; other site 936156006520 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156006521 putative active site [active] 936156006522 heme pocket [chemical binding]; other site 936156006523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156006524 dimer interface [polypeptide binding]; other site 936156006525 phosphorylation site [posttranslational modification] 936156006526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156006527 ATP binding site [chemical binding]; other site 936156006528 Mg2+ binding site [ion binding]; other site 936156006529 G-X-G motif; other site 936156006530 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936156006531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156006532 active site 936156006533 phosphorylation site [posttranslational modification] 936156006534 intermolecular recognition site; other site 936156006535 dimerization interface [polypeptide binding]; other site 936156006536 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936156006537 DNA binding site [nucleotide binding] 936156006538 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 936156006539 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 936156006540 GDP-binding site [chemical binding]; other site 936156006541 ACT binding site; other site 936156006542 IMP binding site; other site 936156006543 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156006544 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 936156006545 active site 936156006546 replicative DNA helicase; Provisional; Region: PRK05748 936156006547 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 936156006548 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 936156006549 Walker A motif; other site 936156006550 ATP binding site [chemical binding]; other site 936156006551 Walker B motif; other site 936156006552 DNA binding loops [nucleotide binding] 936156006553 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 936156006554 YycC-like protein; Region: YycC; pfam14174 936156006555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156006556 cyanate transporter; Region: CynX; TIGR00896 936156006557 putative substrate translocation pore; other site 936156006558 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 936156006559 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 936156006560 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 936156006561 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 936156006562 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 936156006563 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 936156006564 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 936156006565 diguanylate cyclase; Region: GGDEF; smart00267 936156006566 DHH family; Region: DHH; pfam01368 936156006567 DHHA1 domain; Region: DHHA1; pfam02272 936156006568 Predicted membrane protein [Function unknown]; Region: COG4241 936156006569 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 936156006570 Predicted transcriptional regulators [Transcription]; Region: COG1733 936156006571 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 936156006572 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 936156006573 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 936156006574 DHHA2 domain; Region: DHHA2; pfam02833 936156006575 D-galactonate transporter; Region: 2A0114; TIGR00893 936156006576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156006577 putative substrate translocation pore; other site 936156006578 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 936156006579 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 936156006580 DNA binding residues [nucleotide binding] 936156006581 dimer interface [polypeptide binding]; other site 936156006582 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 936156006583 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 936156006584 SnoaL-like domain; Region: SnoaL_3; pfam13474 936156006585 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 936156006586 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 936156006587 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 936156006588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156006589 putative substrate translocation pore; other site 936156006590 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156006591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156006592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156006593 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 936156006594 putative dimerization interface [polypeptide binding]; other site 936156006595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156006596 Coenzyme A binding pocket [chemical binding]; other site 936156006597 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 936156006598 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156006599 MarR family; Region: MarR; pfam01047 936156006600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156006601 Coenzyme A binding pocket [chemical binding]; other site 936156006602 Predicted membrane protein [Function unknown]; Region: COG2364 936156006603 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 936156006604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156006605 Coenzyme A binding pocket [chemical binding]; other site 936156006606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 936156006607 RibD C-terminal domain; Region: RibD_C; cl17279 936156006608 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 936156006609 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936156006610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156006611 putative substrate translocation pore; other site 936156006612 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 936156006613 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 936156006614 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 936156006615 EamA-like transporter family; Region: EamA; pfam00892 936156006616 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 936156006617 EamA-like transporter family; Region: EamA; pfam00892 936156006618 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 936156006619 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 936156006620 catalytic residues [active] 936156006621 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 936156006622 CAAX protease self-immunity; Region: Abi; pfam02517 936156006623 benzoate transport; Region: 2A0115; TIGR00895 936156006624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156006625 putative substrate translocation pore; other site 936156006626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156006627 maltose O-acetyltransferase; Provisional; Region: PRK10092 936156006628 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 936156006629 active site 936156006630 substrate binding site [chemical binding]; other site 936156006631 trimer interface [polypeptide binding]; other site 936156006632 CoA binding site [chemical binding]; other site 936156006633 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156006634 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 936156006635 putative metal binding site [ion binding]; other site 936156006636 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936156006637 DNA binding site [nucleotide binding] 936156006638 domain linker motif; other site 936156006639 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 936156006640 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 936156006641 putative dimerization interface [polypeptide binding]; other site 936156006642 putative ligand binding site [chemical binding]; other site 936156006643 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 936156006644 active site 936156006645 putative catalytic site [active] 936156006646 DNA binding site [nucleotide binding] 936156006647 putative phosphate binding site [ion binding]; other site 936156006648 metal binding site A [ion binding]; metal-binding site 936156006649 AP binding site [nucleotide binding]; other site 936156006650 metal binding site B [ion binding]; metal-binding site 936156006651 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 936156006652 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 936156006653 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 936156006654 dimer interface [polypeptide binding]; other site 936156006655 ssDNA binding site [nucleotide binding]; other site 936156006656 tetramer (dimer of dimers) interface [polypeptide binding]; other site 936156006657 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 936156006658 GTP-binding protein YchF; Reviewed; Region: PRK09601 936156006659 YchF GTPase; Region: YchF; cd01900 936156006660 G1 box; other site 936156006661 GTP/Mg2+ binding site [chemical binding]; other site 936156006662 Switch I region; other site 936156006663 G2 box; other site 936156006664 Switch II region; other site 936156006665 G3 box; other site 936156006666 G4 box; other site 936156006667 G5 box; other site 936156006668 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 936156006669 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 936156006670 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 936156006671 putative [4Fe-4S] binding site [ion binding]; other site 936156006672 putative molybdopterin cofactor binding site [chemical binding]; other site 936156006673 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 936156006674 molybdopterin cofactor binding site; other site 936156006675 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 936156006676 Uncharacterized membrane protein [Function unknown]; Region: COG3949 936156006677 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 936156006678 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 936156006679 ParB-like nuclease domain; Region: ParB; smart00470 936156006680 KorB domain; Region: KorB; pfam08535 936156006681 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 936156006682 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 936156006683 P-loop; other site 936156006684 Magnesium ion binding site [ion binding]; other site 936156006685 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 936156006686 Magnesium ion binding site [ion binding]; other site 936156006687 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 936156006688 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 936156006689 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 936156006690 ParB-like nuclease domain; Region: ParB; smart00470 936156006691 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 936156006692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156006693 S-adenosylmethionine binding site [chemical binding]; other site 936156006694 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 936156006695 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 936156006696 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 936156006697 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 936156006698 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 936156006699 trmE is a tRNA modification GTPase; Region: trmE; cd04164 936156006700 G1 box; other site 936156006701 GTP/Mg2+ binding site [chemical binding]; other site 936156006702 Switch I region; other site 936156006703 G2 box; other site 936156006704 Switch II region; other site 936156006705 G3 box; other site 936156006706 G4 box; other site 936156006707 G5 box; other site 936156006708 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 936156006709 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 936156006710 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 936156006711 G-X-X-G motif; other site 936156006712 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 936156006713 RxxxH motif; other site 936156006714 OxaA-like protein precursor; Validated; Region: PRK02944 936156006715 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 936156006716 ribonuclease P; Reviewed; Region: rnpA; PRK00499 936156006717 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 936156006718 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 936156006719 DnaA N-terminal domain; Region: DnaA_N; pfam11638 936156006720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156006721 Walker A motif; other site 936156006722 ATP binding site [chemical binding]; other site 936156006723 Walker B motif; other site 936156006724 arginine finger; other site 936156006725 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 936156006726 DnaA box-binding interface [nucleotide binding]; other site 936156006727 DNA polymerase III subunit beta; Validated; Region: PRK05643 936156006728 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 936156006729 putative DNA binding surface [nucleotide binding]; other site 936156006730 dimer interface [polypeptide binding]; other site 936156006731 beta-clamp/clamp loader binding surface; other site 936156006732 beta-clamp/translesion DNA polymerase binding surface; other site 936156006733 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 936156006734 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 936156006735 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 936156006736 Walker A/P-loop; other site 936156006737 ATP binding site [chemical binding]; other site 936156006738 Q-loop/lid; other site 936156006739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936156006740 ABC transporter signature motif; other site 936156006741 Walker B; other site 936156006742 D-loop; other site 936156006743 H-loop/switch region; other site 936156006744 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 936156006745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156006746 ATP binding site [chemical binding]; other site 936156006747 Mg2+ binding site [ion binding]; other site 936156006748 G-X-G motif; other site 936156006749 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 936156006750 anchoring element; other site 936156006751 dimer interface [polypeptide binding]; other site 936156006752 ATP binding site [chemical binding]; other site 936156006753 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 936156006754 active site 936156006755 putative metal-binding site [ion binding]; other site 936156006756 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 936156006757 DNA gyrase subunit A; Validated; Region: PRK05560 936156006758 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 936156006759 CAP-like domain; other site 936156006760 active site 936156006761 primary dimer interface [polypeptide binding]; other site 936156006762 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936156006763 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936156006764 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936156006765 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936156006766 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936156006767 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936156006768 YaaC-like Protein; Region: YaaC; pfam14175 936156006769 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 936156006770 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 936156006771 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 936156006772 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 936156006773 active site 936156006774 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 936156006775 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 936156006776 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 936156006777 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 936156006778 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 936156006779 active site 936156006780 multimer interface [polypeptide binding]; other site 936156006781 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 936156006782 Glutamine amidotransferase class-I; Region: GATase; pfam00117 936156006783 predicted active site [active] 936156006784 catalytic triad [active] 936156006785 seryl-tRNA synthetase; Provisional; Region: PRK05431 936156006786 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 936156006787 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 936156006788 dimer interface [polypeptide binding]; other site 936156006789 active site 936156006790 motif 1; other site 936156006791 motif 2; other site 936156006792 motif 3; other site 936156006793 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 936156006794 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 936156006795 Substrate-binding site [chemical binding]; other site 936156006796 Substrate specificity [chemical binding]; other site 936156006797 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 936156006798 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 936156006799 Substrate-binding site [chemical binding]; other site 936156006800 Substrate specificity [chemical binding]; other site 936156006801 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 936156006802 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156006803 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156006804 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 936156006805 active site 936156006806 Isochorismatase family; Region: Isochorismatase; pfam00857 936156006807 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 936156006808 catalytic triad [active] 936156006809 conserved cis-peptide bond; other site 936156006810 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 936156006811 nucleoside/Zn binding site; other site 936156006812 dimer interface [polypeptide binding]; other site 936156006813 catalytic motif [active] 936156006814 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 936156006815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156006816 Walker A motif; other site 936156006817 ATP binding site [chemical binding]; other site 936156006818 Walker B motif; other site 936156006819 arginine finger; other site 936156006820 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 936156006821 hypothetical protein; Validated; Region: PRK00153 936156006822 recombination protein RecR; Reviewed; Region: recR; PRK00076 936156006823 RecR protein; Region: RecR; pfam02132 936156006824 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 936156006825 putative active site [active] 936156006826 putative metal-binding site [ion binding]; other site 936156006827 tetramer interface [polypeptide binding]; other site 936156006828 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 936156006829 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 936156006830 beta-lactamase TEM; Provisional; Region: PRK15442 936156006831 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 936156006832 potential RNA of insufficient length (16S ribosomal RNA) 936156006833 potential RNA of insufficient length (23S ribosomal RNA) 936156006834 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 936156006835 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 936156006836 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 936156006837 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 936156006838 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 936156006839 homodimer interface [polypeptide binding]; other site 936156006840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156006841 catalytic residue [active] 936156006842 thymidylate kinase; Validated; Region: tmk; PRK00698 936156006843 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 936156006844 TMP-binding site; other site 936156006845 ATP-binding site [chemical binding]; other site 936156006846 Protein of unknown function (DUF970); Region: DUF970; pfam06153 936156006847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 936156006848 DNA polymerase III subunit delta'; Validated; Region: PRK08058 936156006849 DNA polymerase III subunit delta'; Validated; Region: PRK08485 936156006850 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 936156006851 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 936156006852 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 936156006853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156006854 S-adenosylmethionine binding site [chemical binding]; other site 936156006855 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 936156006856 GIY-YIG motif/motif A; other site 936156006857 putative active site [active] 936156006858 putative metal binding site [ion binding]; other site 936156006859 Predicted methyltransferases [General function prediction only]; Region: COG0313 936156006860 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 936156006861 putative SAM binding site [chemical binding]; other site 936156006862 putative homodimer interface [polypeptide binding]; other site 936156006863 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 936156006864 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 936156006865 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 936156006866 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 936156006867 active site 936156006868 HIGH motif; other site 936156006869 KMSKS motif; other site 936156006870 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 936156006871 tRNA binding surface [nucleotide binding]; other site 936156006872 anticodon binding site; other site 936156006873 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 936156006874 dimer interface [polypeptide binding]; other site 936156006875 putative tRNA-binding site [nucleotide binding]; other site 936156006876 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 936156006877 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 936156006878 active site 936156006879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 936156006880 Domain of unknown function (DUF348); Region: DUF348; pfam03990 936156006881 Domain of unknown function (DUF348); Region: DUF348; pfam03990 936156006882 Domain of unknown function (DUF348); Region: DUF348; pfam03990 936156006883 G5 domain; Region: G5; pfam07501 936156006884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 936156006885 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 936156006886 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 936156006887 putative active site [active] 936156006888 putative metal binding site [ion binding]; other site 936156006889 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 936156006890 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 936156006891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156006892 S-adenosylmethionine binding site [chemical binding]; other site 936156006893 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 936156006894 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 936156006895 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 936156006896 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 936156006897 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 936156006898 pur operon repressor; Provisional; Region: PRK09213 936156006899 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 936156006900 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936156006901 active site 936156006902 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 936156006903 homotrimer interaction site [polypeptide binding]; other site 936156006904 putative active site [active] 936156006905 regulatory protein SpoVG; Reviewed; Region: PRK13259 936156006906 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 936156006907 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 936156006908 Substrate binding site; other site 936156006909 Mg++ binding site; other site 936156006910 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 936156006911 active site 936156006912 substrate binding site [chemical binding]; other site 936156006913 CoA binding site [chemical binding]; other site 936156006914 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 936156006915 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 936156006916 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936156006917 active site 936156006918 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 936156006919 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 936156006920 5S rRNA interface [nucleotide binding]; other site 936156006921 CTC domain interface [polypeptide binding]; other site 936156006922 L16 interface [polypeptide binding]; other site 936156006923 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 936156006924 putative active site [active] 936156006925 catalytic residue [active] 936156006926 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 936156006927 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 936156006928 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 936156006929 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936156006930 ATP binding site [chemical binding]; other site 936156006931 putative Mg++ binding site [ion binding]; other site 936156006932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156006933 nucleotide binding region [chemical binding]; other site 936156006934 ATP-binding site [chemical binding]; other site 936156006935 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 936156006936 stage V sporulation protein T; Region: spore_V_T; TIGR02851 936156006937 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 936156006938 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 936156006939 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 936156006940 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 936156006941 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 936156006942 putative SAM binding site [chemical binding]; other site 936156006943 putative homodimer interface [polypeptide binding]; other site 936156006944 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 936156006945 homodimer interface [polypeptide binding]; other site 936156006946 metal binding site [ion binding]; metal-binding site 936156006947 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 936156006948 homodimer interface [polypeptide binding]; other site 936156006949 active site 936156006950 putative chemical substrate binding site [chemical binding]; other site 936156006951 metal binding site [ion binding]; metal-binding site 936156006952 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936156006953 RNA binding surface [nucleotide binding]; other site 936156006954 sporulation protein YabP; Region: spore_yabP; TIGR02892 936156006955 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 936156006956 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 936156006957 Septum formation initiator; Region: DivIC; pfam04977 936156006958 hypothetical protein; Provisional; Region: PRK08582 936156006959 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 936156006960 RNA binding site [nucleotide binding]; other site 936156006961 stage II sporulation protein E; Region: spore_II_E; TIGR02865 936156006962 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 936156006963 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 936156006964 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 936156006965 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 936156006966 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 936156006967 metal ion-dependent adhesion site (MIDAS); other site 936156006968 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 936156006969 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 936156006970 active site 936156006971 ATP binding site [chemical binding]; other site 936156006972 substrate binding site [chemical binding]; other site 936156006973 activation loop (A-loop); other site 936156006974 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 936156006975 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 936156006976 Ligand Binding Site [chemical binding]; other site 936156006977 TilS substrate C-terminal domain; Region: TilS_C; smart00977 936156006978 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936156006979 active site 936156006980 FtsH Extracellular; Region: FtsH_ext; pfam06480 936156006981 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 936156006982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156006983 Walker A motif; other site 936156006984 ATP binding site [chemical binding]; other site 936156006985 Walker B motif; other site 936156006986 arginine finger; other site 936156006987 Peptidase family M41; Region: Peptidase_M41; pfam01434 936156006988 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936156006989 nucleotide binding site [chemical binding]; other site 936156006990 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 936156006991 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 936156006992 dimerization interface [polypeptide binding]; other site 936156006993 domain crossover interface; other site 936156006994 redox-dependent activation switch; other site 936156006995 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 936156006996 SurA N-terminal domain; Region: SurA_N_3; cl07813 936156006997 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 936156006998 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 936156006999 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 936156007000 dimer interface [polypeptide binding]; other site 936156007001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156007002 catalytic residue [active] 936156007003 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 936156007004 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 936156007005 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 936156007006 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 936156007007 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 936156007008 glutamine binding [chemical binding]; other site 936156007009 catalytic triad [active] 936156007010 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 936156007011 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 936156007012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156007013 catalytic residue [active] 936156007014 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 936156007015 dihydropteroate synthase; Region: DHPS; TIGR01496 936156007016 substrate binding pocket [chemical binding]; other site 936156007017 dimer interface [polypeptide binding]; other site 936156007018 inhibitor binding site; inhibition site 936156007019 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 936156007020 homooctamer interface [polypeptide binding]; other site 936156007021 active site 936156007022 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 936156007023 catalytic center binding site [active] 936156007024 ATP binding site [chemical binding]; other site 936156007025 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936156007026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156007027 non-specific DNA binding site [nucleotide binding]; other site 936156007028 salt bridge; other site 936156007029 sequence-specific DNA binding site [nucleotide binding]; other site 936156007030 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 936156007031 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 936156007032 FMN binding site [chemical binding]; other site 936156007033 active site 936156007034 catalytic residues [active] 936156007035 substrate binding site [chemical binding]; other site 936156007036 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 936156007037 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 936156007038 dimer interface [polypeptide binding]; other site 936156007039 putative anticodon binding site; other site 936156007040 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 936156007041 motif 1; other site 936156007042 active site 936156007043 motif 2; other site 936156007044 motif 3; other site 936156007045 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 936156007046 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 936156007047 UvrB/uvrC motif; Region: UVR; pfam02151 936156007048 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 936156007049 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 936156007050 ADP binding site [chemical binding]; other site 936156007051 phosphagen binding site; other site 936156007052 substrate specificity loop; other site 936156007053 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 936156007054 Clp amino terminal domain; Region: Clp_N; pfam02861 936156007055 Clp amino terminal domain; Region: Clp_N; pfam02861 936156007056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156007057 Walker A motif; other site 936156007058 ATP binding site [chemical binding]; other site 936156007059 Walker B motif; other site 936156007060 arginine finger; other site 936156007061 UvrB/uvrC motif; Region: UVR; pfam02151 936156007062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156007063 Walker A motif; other site 936156007064 ATP binding site [chemical binding]; other site 936156007065 Walker B motif; other site 936156007066 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 936156007067 DNA repair protein RadA; Provisional; Region: PRK11823 936156007068 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 936156007069 Walker A motif/ATP binding site; other site 936156007070 ATP binding site [chemical binding]; other site 936156007071 Walker B motif; other site 936156007072 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 936156007073 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 936156007074 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 936156007075 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 936156007076 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 936156007077 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 936156007078 putative active site [active] 936156007079 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 936156007080 substrate binding site; other site 936156007081 dimer interface; other site 936156007082 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 936156007083 homotrimer interaction site [polypeptide binding]; other site 936156007084 zinc binding site [ion binding]; other site 936156007085 CDP-binding sites; other site 936156007086 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 936156007087 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 936156007088 active site 936156007089 HIGH motif; other site 936156007090 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 936156007091 active site 936156007092 KMSKS motif; other site 936156007093 serine O-acetyltransferase; Region: cysE; TIGR01172 936156007094 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 936156007095 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 936156007096 trimer interface [polypeptide binding]; other site 936156007097 active site 936156007098 substrate binding site [chemical binding]; other site 936156007099 CoA binding site [chemical binding]; other site 936156007100 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 936156007101 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 936156007102 active site 936156007103 HIGH motif; other site 936156007104 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 936156007105 KMSKS motif; other site 936156007106 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 936156007107 tRNA binding surface [nucleotide binding]; other site 936156007108 anticodon binding site; other site 936156007109 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 936156007110 active site 936156007111 metal binding site [ion binding]; metal-binding site 936156007112 dimerization interface [polypeptide binding]; other site 936156007113 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 936156007114 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 936156007115 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 936156007116 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 936156007117 RNA polymerase factor sigma-70; Validated; Region: PRK08295 936156007118 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156007119 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 936156007120 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 936156007121 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 936156007122 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 936156007123 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 936156007124 putative homodimer interface [polypeptide binding]; other site 936156007125 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 936156007126 heterodimer interface [polypeptide binding]; other site 936156007127 homodimer interface [polypeptide binding]; other site 936156007128 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 936156007129 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 936156007130 23S rRNA interface [nucleotide binding]; other site 936156007131 L7/L12 interface [polypeptide binding]; other site 936156007132 putative thiostrepton binding site; other site 936156007133 L25 interface [polypeptide binding]; other site 936156007134 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 936156007135 mRNA/rRNA interface [nucleotide binding]; other site 936156007136 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 936156007137 23S rRNA interface [nucleotide binding]; other site 936156007138 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 936156007139 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 936156007140 core dimer interface [polypeptide binding]; other site 936156007141 peripheral dimer interface [polypeptide binding]; other site 936156007142 L10 interface [polypeptide binding]; other site 936156007143 L11 interface [polypeptide binding]; other site 936156007144 putative EF-Tu interaction site [polypeptide binding]; other site 936156007145 putative EF-G interaction site [polypeptide binding]; other site 936156007146 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 936156007147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156007148 S-adenosylmethionine binding site [chemical binding]; other site 936156007149 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 936156007150 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 936156007151 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 936156007152 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 936156007153 RPB1 interaction site [polypeptide binding]; other site 936156007154 RPB10 interaction site [polypeptide binding]; other site 936156007155 RPB11 interaction site [polypeptide binding]; other site 936156007156 RPB3 interaction site [polypeptide binding]; other site 936156007157 RPB12 interaction site [polypeptide binding]; other site 936156007158 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 936156007159 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 936156007160 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 936156007161 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 936156007162 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 936156007163 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 936156007164 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 936156007165 G-loop; other site 936156007166 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 936156007167 DNA binding site [nucleotide binding] 936156007168 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 936156007169 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 936156007170 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 936156007171 S17 interaction site [polypeptide binding]; other site 936156007172 S8 interaction site; other site 936156007173 16S rRNA interaction site [nucleotide binding]; other site 936156007174 streptomycin interaction site [chemical binding]; other site 936156007175 23S rRNA interaction site [nucleotide binding]; other site 936156007176 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 936156007177 30S ribosomal protein S7; Validated; Region: PRK05302 936156007178 elongation factor G; Reviewed; Region: PRK00007 936156007179 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 936156007180 G1 box; other site 936156007181 putative GEF interaction site [polypeptide binding]; other site 936156007182 GTP/Mg2+ binding site [chemical binding]; other site 936156007183 Switch I region; other site 936156007184 G2 box; other site 936156007185 G3 box; other site 936156007186 Switch II region; other site 936156007187 G4 box; other site 936156007188 G5 box; other site 936156007189 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 936156007190 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 936156007191 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 936156007192 elongation factor Tu; Reviewed; Region: PRK00049 936156007193 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 936156007194 G1 box; other site 936156007195 GEF interaction site [polypeptide binding]; other site 936156007196 GTP/Mg2+ binding site [chemical binding]; other site 936156007197 Switch I region; other site 936156007198 G2 box; other site 936156007199 G3 box; other site 936156007200 Switch II region; other site 936156007201 G4 box; other site 936156007202 G5 box; other site 936156007203 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 936156007204 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 936156007205 Antibiotic Binding Site [chemical binding]; other site 936156007206 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 936156007207 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 936156007208 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 936156007209 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 936156007210 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 936156007211 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 936156007212 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 936156007213 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 936156007214 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 936156007215 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 936156007216 putative translocon binding site; other site 936156007217 protein-rRNA interface [nucleotide binding]; other site 936156007218 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 936156007219 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 936156007220 G-X-X-G motif; other site 936156007221 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 936156007222 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 936156007223 23S rRNA interface [nucleotide binding]; other site 936156007224 5S rRNA interface [nucleotide binding]; other site 936156007225 putative antibiotic binding site [chemical binding]; other site 936156007226 L25 interface [polypeptide binding]; other site 936156007227 L27 interface [polypeptide binding]; other site 936156007228 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 936156007229 23S rRNA interface [nucleotide binding]; other site 936156007230 putative translocon interaction site; other site 936156007231 signal recognition particle (SRP54) interaction site; other site 936156007232 L23 interface [polypeptide binding]; other site 936156007233 trigger factor interaction site; other site 936156007234 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 936156007235 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 936156007236 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 936156007237 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 936156007238 RNA binding site [nucleotide binding]; other site 936156007239 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 936156007240 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 936156007241 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 936156007242 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 936156007243 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 936156007244 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 936156007245 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 936156007246 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 936156007247 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 936156007248 5S rRNA interface [nucleotide binding]; other site 936156007249 L27 interface [polypeptide binding]; other site 936156007250 23S rRNA interface [nucleotide binding]; other site 936156007251 L5 interface [polypeptide binding]; other site 936156007252 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 936156007253 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 936156007254 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 936156007255 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 936156007256 23S rRNA binding site [nucleotide binding]; other site 936156007257 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 936156007258 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 936156007259 SecY translocase; Region: SecY; pfam00344 936156007260 adenylate kinase; Reviewed; Region: adk; PRK00279 936156007261 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 936156007262 AMP-binding site [chemical binding]; other site 936156007263 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 936156007264 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 936156007265 active site 936156007266 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 936156007267 RNA binding site [nucleotide binding]; other site 936156007268 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 936156007269 rRNA binding site [nucleotide binding]; other site 936156007270 predicted 30S ribosome binding site; other site 936156007271 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 936156007272 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 936156007273 30S ribosomal protein S13; Region: bact_S13; TIGR03631 936156007274 30S ribosomal protein S11; Validated; Region: PRK05309 936156007275 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 936156007276 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 936156007277 alphaNTD homodimer interface [polypeptide binding]; other site 936156007278 alphaNTD - beta interaction site [polypeptide binding]; other site 936156007279 alphaNTD - beta' interaction site [polypeptide binding]; other site 936156007280 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 936156007281 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 936156007282 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 936156007283 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 936156007284 Walker A/P-loop; other site 936156007285 ATP binding site [chemical binding]; other site 936156007286 Q-loop/lid; other site 936156007287 ABC transporter signature motif; other site 936156007288 Walker B; other site 936156007289 D-loop; other site 936156007290 H-loop/switch region; other site 936156007291 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 936156007292 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 936156007293 Walker A/P-loop; other site 936156007294 ATP binding site [chemical binding]; other site 936156007295 Q-loop/lid; other site 936156007296 ABC transporter signature motif; other site 936156007297 Walker B; other site 936156007298 D-loop; other site 936156007299 H-loop/switch region; other site 936156007300 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 936156007301 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 936156007302 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 936156007303 dimerization interface 3.5A [polypeptide binding]; other site 936156007304 active site 936156007305 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 936156007306 23S rRNA interface [nucleotide binding]; other site 936156007307 L3 interface [polypeptide binding]; other site 936156007308 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 936156007309 Methyltransferase domain; Region: Methyltransf_31; pfam13847 936156007310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156007311 S-adenosylmethionine binding site [chemical binding]; other site 936156007312 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 936156007313 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 936156007314 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 936156007315 active site 936156007316 metal binding site [ion binding]; metal-binding site 936156007317 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 936156007318 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 936156007319 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 936156007320 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 936156007321 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 936156007322 NodB motif; other site 936156007323 putative active site [active] 936156007324 putative catalytic site [active] 936156007325 potential protein location (hypothetical protein BSn5_12370 [Bacillus subtilis BSn5]) that overlaps RNA (tRNA-A) 936156007326 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 936156007327 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 936156007328 Sulfate transporter family; Region: Sulfate_transp; pfam00916 936156007329 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 936156007330 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 936156007331 Sodium Bile acid symporter family; Region: SBF; cl17470 936156007332 Putative esterase; Region: Esterase; pfam00756 936156007333 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 936156007334 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 936156007335 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156007336 dimer interface [polypeptide binding]; other site 936156007337 putative PBP binding regions; other site 936156007338 ABC-ATPase subunit interface; other site 936156007339 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 936156007340 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 936156007341 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156007342 ABC-ATPase subunit interface; other site 936156007343 dimer interface [polypeptide binding]; other site 936156007344 putative PBP binding regions; other site 936156007345 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 936156007346 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 936156007347 putative ligand binding residues [chemical binding]; other site 936156007348 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936156007349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156007350 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 936156007351 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 936156007352 putative ligand binding residues [chemical binding]; other site 936156007353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 936156007354 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 936156007355 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 936156007356 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 936156007357 putative periplasmic esterase; Provisional; Region: PRK03642 936156007358 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 936156007359 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 936156007360 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 936156007361 active site turn [active] 936156007362 phosphorylation site [posttranslational modification] 936156007363 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 936156007364 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 936156007365 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 936156007366 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 936156007367 putative active site [active] 936156007368 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 936156007369 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 936156007370 putative active site [active] 936156007371 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 936156007372 Uncharacterized conserved protein [Function unknown]; Region: COG1683 936156007373 potential protein location (hypothetical protein BSn5_12455 [Bacillus subtilis BSn5]) that overlaps RNA (tRNA-Q) 936156007374 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 936156007375 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156007376 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156007377 DNA binding residues [nucleotide binding] 936156007378 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 936156007379 Putative zinc-finger; Region: zf-HC2; pfam13490 936156007380 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 936156007381 Uncharacterized conserved protein [Function unknown]; Region: COG1624 936156007382 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 936156007383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 936156007384 YbbR-like protein; Region: YbbR; pfam07949 936156007385 YbbR-like protein; Region: YbbR; pfam07949 936156007386 YbbR-like protein; Region: YbbR; pfam07949 936156007387 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 936156007388 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 936156007389 active site 936156007390 substrate binding site [chemical binding]; other site 936156007391 metal binding site [ion binding]; metal-binding site 936156007392 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 936156007393 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 936156007394 glutaminase active site [active] 936156007395 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 936156007396 dimer interface [polypeptide binding]; other site 936156007397 active site 936156007398 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 936156007399 dimer interface [polypeptide binding]; other site 936156007400 active site 936156007401 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 936156007402 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 936156007403 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 936156007404 minor groove reading motif; other site 936156007405 helix-hairpin-helix signature motif; other site 936156007406 substrate binding pocket [chemical binding]; other site 936156007407 active site 936156007408 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 936156007409 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 936156007410 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156007411 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156007412 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 936156007413 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 936156007414 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 936156007415 DNA binding site [nucleotide binding] 936156007416 active site 936156007417 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 936156007418 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 936156007419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 936156007420 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 936156007421 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 936156007422 zinc binding site [ion binding]; other site 936156007423 Uncharacterized conserved protein [Function unknown]; Region: COG5609 936156007424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156007425 dimerization interface [polypeptide binding]; other site 936156007426 putative DNA binding site [nucleotide binding]; other site 936156007427 putative Zn2+ binding site [ion binding]; other site 936156007428 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936156007429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007430 putative substrate translocation pore; other site 936156007431 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449 936156007432 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 936156007433 active site 936156007434 catalytic residues [active] 936156007435 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 936156007436 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 936156007437 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 936156007438 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 936156007439 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 936156007440 active site 936156007441 zinc binding site [ion binding]; other site 936156007442 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 936156007443 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936156007444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936156007445 Walker A/P-loop; other site 936156007446 ATP binding site [chemical binding]; other site 936156007447 Q-loop/lid; other site 936156007448 ABC transporter signature motif; other site 936156007449 Walker B; other site 936156007450 D-loop; other site 936156007451 H-loop/switch region; other site 936156007452 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 936156007453 Response regulator receiver domain; Region: Response_reg; pfam00072 936156007454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156007455 active site 936156007456 phosphorylation site [posttranslational modification] 936156007457 intermolecular recognition site; other site 936156007458 dimerization interface [polypeptide binding]; other site 936156007459 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 936156007460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936156007461 HAMP domain; Region: HAMP; pfam00672 936156007462 dimerization interface [polypeptide binding]; other site 936156007463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156007464 dimer interface [polypeptide binding]; other site 936156007465 phosphorylation site [posttranslational modification] 936156007466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156007467 ATP binding site [chemical binding]; other site 936156007468 Mg2+ binding site [ion binding]; other site 936156007469 G-X-G motif; other site 936156007470 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 936156007471 active site 936156007472 ATP binding site [chemical binding]; other site 936156007473 substrate binding site [chemical binding]; other site 936156007474 activation loop (A-loop); other site 936156007475 putative transport protein YifK; Provisional; Region: PRK10746 936156007476 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 936156007477 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 936156007478 Cytochrome P450; Region: p450; cl12078 936156007479 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 936156007480 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 936156007481 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 936156007482 active site 936156007483 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 936156007484 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 936156007485 active site 936156007486 catalytic site [active] 936156007487 metal binding site [ion binding]; metal-binding site 936156007488 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 936156007489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007490 putative substrate translocation pore; other site 936156007491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007492 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 936156007493 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156007494 MarR family; Region: MarR; pfam01047 936156007495 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 936156007496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156007497 Coenzyme A binding pocket [chemical binding]; other site 936156007498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007499 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156007500 putative substrate translocation pore; other site 936156007501 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 936156007502 EamA-like transporter family; Region: EamA; pfam00892 936156007503 EamA-like transporter family; Region: EamA; pfam00892 936156007504 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 936156007505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156007506 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936156007507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156007508 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 936156007509 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936156007510 ATP-grasp domain; Region: ATP-grasp; pfam02222 936156007511 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 936156007512 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 936156007513 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 936156007514 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 936156007515 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 936156007516 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 936156007517 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 936156007518 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 936156007519 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 936156007520 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 936156007521 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 936156007522 active site residue [active] 936156007523 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 936156007524 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 936156007525 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 936156007526 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 936156007527 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 936156007528 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 936156007529 active site turn [active] 936156007530 phosphorylation site [posttranslational modification] 936156007531 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 936156007532 HPr interaction site; other site 936156007533 glycerol kinase (GK) interaction site [polypeptide binding]; other site 936156007534 active site 936156007535 phosphorylation site [posttranslational modification] 936156007536 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 936156007537 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 936156007538 active site 936156007539 trimer interface [polypeptide binding]; other site 936156007540 allosteric site; other site 936156007541 active site lid [active] 936156007542 hexamer (dimer of trimers) interface [polypeptide binding]; other site 936156007543 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 936156007544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156007545 DNA-binding site [nucleotide binding]; DNA binding site 936156007546 UTRA domain; Region: UTRA; pfam07702 936156007547 Predicted integral membrane protein [Function unknown]; Region: COG5658 936156007548 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 936156007549 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 936156007550 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 936156007551 homodimer interface [polypeptide binding]; other site 936156007552 substrate-cofactor binding pocket; other site 936156007553 catalytic residue [active] 936156007554 S-methylmethionine transporter; Provisional; Region: PRK11387 936156007555 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 936156007556 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 936156007557 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 936156007558 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 936156007559 glutaminase; Reviewed; Region: PRK12357 936156007560 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 936156007561 Chorismate mutase type II; Region: CM_2; cl00693 936156007562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936156007563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156007564 ATP binding site [chemical binding]; other site 936156007565 Mg2+ binding site [ion binding]; other site 936156007566 G-X-G motif; other site 936156007567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156007568 Response regulator receiver domain; Region: Response_reg; pfam00072 936156007569 active site 936156007570 phosphorylation site [posttranslational modification] 936156007571 intermolecular recognition site; other site 936156007572 dimerization interface [polypeptide binding]; other site 936156007573 YcbB domain; Region: YcbB; pfam08664 936156007574 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 936156007575 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 936156007576 putative active site [active] 936156007577 catalytic residue [active] 936156007578 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 936156007579 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 936156007580 NAD(P) binding site [chemical binding]; other site 936156007581 catalytic residues [active] 936156007582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007583 D-galactonate transporter; Region: 2A0114; TIGR00893 936156007584 putative substrate translocation pore; other site 936156007585 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 936156007586 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 936156007587 active site 936156007588 tetramer interface [polypeptide binding]; other site 936156007589 Transcriptional regulators [Transcription]; Region: FadR; COG2186 936156007590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156007591 DNA-binding site [nucleotide binding]; DNA binding site 936156007592 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 936156007593 galactarate dehydratase; Region: galactar-dH20; TIGR03248 936156007594 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 936156007595 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 936156007596 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 936156007597 putative active site [active] 936156007598 putative substrate binding site [chemical binding]; other site 936156007599 Phosphotransferase enzyme family; Region: APH; pfam01636 936156007600 ATP binding site [chemical binding]; other site 936156007601 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 936156007602 dodecamer interface 1 [polypeptide binding]; other site 936156007603 dodecamer interface 2 [polypeptide binding]; other site 936156007604 trimer interface [polypeptide binding]; other site 936156007605 TRAP binding interface [polypeptide binding]; other site 936156007606 Zn binding site [ion binding]; other site 936156007607 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 936156007608 EamA-like transporter family; Region: EamA; pfam00892 936156007609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936156007610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156007611 active site 936156007612 phosphorylation site [posttranslational modification] 936156007613 intermolecular recognition site; other site 936156007614 dimerization interface [polypeptide binding]; other site 936156007615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936156007616 DNA binding site [nucleotide binding] 936156007617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936156007618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156007619 dimer interface [polypeptide binding]; other site 936156007620 phosphorylation site [posttranslational modification] 936156007621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156007622 ATP binding site [chemical binding]; other site 936156007623 Mg2+ binding site [ion binding]; other site 936156007624 G-X-G motif; other site 936156007625 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 936156007626 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 936156007627 Walker A/P-loop; other site 936156007628 ATP binding site [chemical binding]; other site 936156007629 Q-loop/lid; other site 936156007630 ABC transporter signature motif; other site 936156007631 Walker B; other site 936156007632 D-loop; other site 936156007633 H-loop/switch region; other site 936156007634 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 936156007635 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 936156007636 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 936156007637 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 936156007638 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 936156007639 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 936156007640 metal ion-dependent adhesion site (MIDAS); other site 936156007641 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 936156007642 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 936156007643 putative active site [active] 936156007644 putative metal binding site [ion binding]; other site 936156007645 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 936156007646 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 936156007647 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 936156007648 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 936156007649 putative substrate binding pocket [chemical binding]; other site 936156007650 AC domain interface; other site 936156007651 catalytic triad [active] 936156007652 AB domain interface; other site 936156007653 interchain disulfide; other site 936156007654 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 936156007655 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 936156007656 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936156007657 catalytic residue [active] 936156007658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156007660 putative substrate translocation pore; other site 936156007661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156007663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156007664 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 936156007665 active site 936156007666 homotetramer interface [polypeptide binding]; other site 936156007667 homodimer interface [polypeptide binding]; other site 936156007668 Lipase (class 2); Region: Lipase_2; pfam01674 936156007669 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 936156007670 Predicted membrane protein/domain [Function unknown]; Region: COG1714 936156007671 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 936156007672 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 936156007673 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 936156007674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156007675 ATP binding site [chemical binding]; other site 936156007676 Mg2+ binding site [ion binding]; other site 936156007677 G-X-G motif; other site 936156007678 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 936156007679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156007680 active site 936156007681 phosphorylation site [posttranslational modification] 936156007682 intermolecular recognition site; other site 936156007683 dimerization interface [polypeptide binding]; other site 936156007684 LytTr DNA-binding domain; Region: LytTR; pfam04397 936156007685 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 936156007686 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 936156007687 Walker A/P-loop; other site 936156007688 ATP binding site [chemical binding]; other site 936156007689 Q-loop/lid; other site 936156007690 ABC transporter signature motif; other site 936156007691 Walker B; other site 936156007692 D-loop; other site 936156007693 H-loop/switch region; other site 936156007694 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 936156007695 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 936156007696 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936156007697 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936156007698 active site 936156007699 catalytic tetrad [active] 936156007700 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 936156007701 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 936156007702 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 936156007703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 936156007704 binding surface 936156007705 TPR motif; other site 936156007706 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156007707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156007708 binding surface 936156007709 TPR motif; other site 936156007710 glucose-1-dehydrogenase; Provisional; Region: PRK08936 936156007711 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 936156007712 NAD binding site [chemical binding]; other site 936156007713 homodimer interface [polypeptide binding]; other site 936156007714 active site 936156007715 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 936156007716 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 936156007717 Ca binding site [ion binding]; other site 936156007718 active site 936156007719 catalytic site [active] 936156007720 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 936156007721 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 936156007722 metal binding site [ion binding]; metal-binding site 936156007723 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 936156007724 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 936156007725 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 936156007726 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156007727 ABC-ATPase subunit interface; other site 936156007728 dimer interface [polypeptide binding]; other site 936156007729 putative PBP binding regions; other site 936156007730 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 936156007731 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 936156007732 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 936156007733 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 936156007734 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 936156007735 putative metal binding site [ion binding]; other site 936156007736 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 936156007737 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 936156007738 putative metal binding site [ion binding]; other site 936156007739 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 936156007740 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 936156007741 putative metal binding site [ion binding]; other site 936156007742 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 936156007743 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 936156007744 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 936156007745 benzoate transport; Region: 2A0115; TIGR00895 936156007746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007747 putative substrate translocation pore; other site 936156007748 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936156007749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007750 putative substrate translocation pore; other site 936156007751 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156007752 dimerization interface [polypeptide binding]; other site 936156007753 putative DNA binding site [nucleotide binding]; other site 936156007754 putative Zn2+ binding site [ion binding]; other site 936156007755 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 936156007756 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 936156007757 Walker A/P-loop; other site 936156007758 ATP binding site [chemical binding]; other site 936156007759 Q-loop/lid; other site 936156007760 ABC transporter signature motif; other site 936156007761 Walker B; other site 936156007762 D-loop; other site 936156007763 H-loop/switch region; other site 936156007764 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 936156007765 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 936156007766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156007767 dimer interface [polypeptide binding]; other site 936156007768 conserved gate region; other site 936156007769 putative PBP binding loops; other site 936156007770 ABC-ATPase subunit interface; other site 936156007771 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 936156007772 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 936156007773 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 936156007774 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 936156007775 amidohydrolase; Region: amidohydrolases; TIGR01891 936156007776 metal binding site [ion binding]; metal-binding site 936156007777 putative dimer interface [polypeptide binding]; other site 936156007778 Predicted membrane protein [Function unknown]; Region: COG1288 936156007779 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 936156007780 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 936156007781 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 936156007782 active site 936156007783 Ca binding site [ion binding]; other site 936156007784 catalytic site [active] 936156007785 Aamy_C domain; Region: Aamy_C; smart00632 936156007786 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 936156007787 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 936156007788 tetramer (dimer of dimers) interface [polypeptide binding]; other site 936156007789 NAD binding site [chemical binding]; other site 936156007790 dimer interface [polypeptide binding]; other site 936156007791 substrate binding site [chemical binding]; other site 936156007792 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 936156007793 L-lactate permease; Region: Lactate_perm; pfam02652 936156007794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007795 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156007796 putative substrate translocation pore; other site 936156007797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007798 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156007799 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156007800 putative DNA binding site [nucleotide binding]; other site 936156007801 putative Zn2+ binding site [ion binding]; other site 936156007802 LysE type translocator; Region: LysE; pfam01810 936156007803 Uncharacterized conserved protein [Function unknown]; Region: COG3403 936156007804 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 936156007805 Spore germination protein; Region: Spore_permease; cl17796 936156007806 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 936156007807 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 936156007808 NAD+ synthetase; Region: nadE; TIGR00552 936156007809 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 936156007810 homodimer interface [polypeptide binding]; other site 936156007811 NAD binding pocket [chemical binding]; other site 936156007812 ATP binding pocket [chemical binding]; other site 936156007813 Mg binding site [ion binding]; other site 936156007814 active-site loop [active] 936156007815 AAA domain; Region: AAA_17; cl17253 936156007816 AAA domain; Region: AAA_18; pfam13238 936156007817 shikimate kinase; Reviewed; Region: aroK; PRK00131 936156007818 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 936156007819 ADP binding site [chemical binding]; other site 936156007820 magnesium binding site [ion binding]; other site 936156007821 putative shikimate binding site; other site 936156007822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156007823 S-adenosylmethionine binding site [chemical binding]; other site 936156007824 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156007825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156007826 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936156007827 dimerization interface [polypeptide binding]; other site 936156007828 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 936156007829 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 936156007830 Proline dehydrogenase; Region: Pro_dh; pfam01619 936156007831 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 936156007832 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 936156007833 Glutamate binding site [chemical binding]; other site 936156007834 homodimer interface [polypeptide binding]; other site 936156007835 NAD binding site [chemical binding]; other site 936156007836 catalytic residues [active] 936156007837 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 936156007838 Na binding site [ion binding]; other site 936156007839 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 936156007840 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 936156007841 Predicted membrane protein [Function unknown]; Region: COG3689 936156007842 Predicted permeases [General function prediction only]; Region: COG0701 936156007843 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 936156007844 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 936156007845 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936156007846 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936156007847 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 936156007848 active site 936156007849 SAM binding site [chemical binding]; other site 936156007850 homodimer interface [polypeptide binding]; other site 936156007851 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 936156007852 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 936156007853 active site 936156007854 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 936156007855 [2Fe-2S] cluster binding site [ion binding]; other site 936156007856 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 936156007857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936156007858 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 936156007859 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 936156007860 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 936156007861 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 936156007862 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 936156007863 [4Fe-4S] binding site [ion binding]; other site 936156007864 molybdopterin cofactor binding site; other site 936156007865 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 936156007866 molybdopterin cofactor binding site; other site 936156007867 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 936156007868 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936156007869 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936156007870 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 936156007871 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 936156007872 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 936156007873 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 936156007874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007875 putative substrate translocation pore; other site 936156007876 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 936156007877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 936156007878 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 936156007879 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 936156007880 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 936156007881 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 936156007882 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 936156007883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156007884 dimer interface [polypeptide binding]; other site 936156007885 conserved gate region; other site 936156007886 putative PBP binding loops; other site 936156007887 ABC-ATPase subunit interface; other site 936156007888 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 936156007889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936156007890 substrate binding pocket [chemical binding]; other site 936156007891 membrane-bound complex binding site; other site 936156007892 hinge residues; other site 936156007893 RDD family; Region: RDD; pfam06271 936156007894 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 936156007895 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 936156007896 beta-galactosidase; Region: BGL; TIGR03356 936156007897 Competence protein J (ComJ); Region: ComJ; pfam11033 936156007898 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 936156007899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936156007900 dimerization interface [polypeptide binding]; other site 936156007901 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936156007902 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936156007903 dimer interface [polypeptide binding]; other site 936156007904 putative CheW interface [polypeptide binding]; other site 936156007905 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 936156007906 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 936156007907 tetramer interface [polypeptide binding]; other site 936156007908 active site 936156007909 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 936156007910 active site 936156007911 dimer interface [polypeptide binding]; other site 936156007912 magnesium binding site [ion binding]; other site 936156007913 Predicted transcriptional regulators [Transcription]; Region: COG1733 936156007914 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 936156007915 Condensation domain; Region: Condensation; pfam00668 936156007916 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156007917 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 936156007918 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936156007919 acyl-activating enzyme (AAE) consensus motif; other site 936156007920 AMP binding site [chemical binding]; other site 936156007921 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156007922 Condensation domain; Region: Condensation; pfam00668 936156007923 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156007924 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 936156007925 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 936156007926 acyl-activating enzyme (AAE) consensus motif; other site 936156007927 AMP binding site [chemical binding]; other site 936156007928 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156007929 Condensation domain; Region: Condensation; pfam00668 936156007930 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156007931 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 936156007932 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936156007933 acyl-activating enzyme (AAE) consensus motif; other site 936156007934 AMP binding site [chemical binding]; other site 936156007935 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156007936 Condensation domain; Region: Condensation; pfam00668 936156007937 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156007938 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 936156007939 potential frameshift: common BLAST hit: gi|255767106|ref|NP_388231.2| surfactin synthetase 936156007940 Condensation domain; Region: Condensation; pfam00668 936156007941 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156007942 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 936156007943 acyl-activating enzyme (AAE) consensus motif; other site 936156007944 AMP binding site [chemical binding]; other site 936156007945 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156007946 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 936156007947 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 936156007948 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 936156007949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007950 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156007951 putative substrate translocation pore; other site 936156007952 YcxB-like protein; Region: YcxB; pfam14317 936156007953 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 936156007954 EamA-like transporter family; Region: EamA; pfam00892 936156007955 EamA-like transporter family; Region: EamA; pfam00892 936156007956 potential frameshift: common BLAST hit: gi|16077425|ref|NP_388238.1| putative PLP-dependent transcriptional regulator 936156007957 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 936156007958 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 936156007959 Predicted membrane protein [Function unknown]; Region: COG2364 936156007960 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156007961 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 936156007962 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 936156007963 Walker A/P-loop; other site 936156007964 ATP binding site [chemical binding]; other site 936156007965 Q-loop/lid; other site 936156007966 ABC transporter signature motif; other site 936156007967 Walker B; other site 936156007968 D-loop; other site 936156007969 H-loop/switch region; other site 936156007970 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 936156007971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156007972 dimer interface [polypeptide binding]; other site 936156007973 conserved gate region; other site 936156007974 putative PBP binding loops; other site 936156007975 ABC-ATPase subunit interface; other site 936156007976 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 936156007977 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936156007978 substrate binding pocket [chemical binding]; other site 936156007979 membrane-bound complex binding site; other site 936156007980 hinge residues; other site 936156007981 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156007982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156007983 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936156007984 dimerization interface [polypeptide binding]; other site 936156007985 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 936156007986 Flavoprotein; Region: Flavoprotein; pfam02441 936156007987 UbiD family decarboxylase; Region: TIGR00148 936156007988 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 936156007989 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 936156007990 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 936156007991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156007992 putative substrate translocation pore; other site 936156007993 POT family; Region: PTR2; pfam00854 936156007994 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 936156007995 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 936156007996 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 936156007997 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 936156007998 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 936156007999 Spore germination protein; Region: Spore_permease; pfam03845 936156008000 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 936156008001 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 936156008002 Walker A/P-loop; other site 936156008003 ATP binding site [chemical binding]; other site 936156008004 Q-loop/lid; other site 936156008005 ABC transporter signature motif; other site 936156008006 Walker B; other site 936156008007 D-loop; other site 936156008008 H-loop/switch region; other site 936156008009 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 936156008010 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 936156008011 FtsX-like permease family; Region: FtsX; pfam02687 936156008012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936156008013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156008014 active site 936156008015 phosphorylation site [posttranslational modification] 936156008016 intermolecular recognition site; other site 936156008017 dimerization interface [polypeptide binding]; other site 936156008018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936156008019 DNA binding site [nucleotide binding] 936156008020 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936156008021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936156008022 dimerization interface [polypeptide binding]; other site 936156008023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156008024 dimer interface [polypeptide binding]; other site 936156008025 phosphorylation site [posttranslational modification] 936156008026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156008027 ATP binding site [chemical binding]; other site 936156008028 Mg2+ binding site [ion binding]; other site 936156008029 G-X-G motif; other site 936156008030 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156008031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156008032 TPR motif; other site 936156008033 binding surface 936156008034 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156008035 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 936156008036 aspartate kinase; Reviewed; Region: PRK09034 936156008037 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 936156008038 putative catalytic residues [active] 936156008039 putative nucleotide binding site [chemical binding]; other site 936156008040 putative aspartate binding site [chemical binding]; other site 936156008041 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 936156008042 allosteric regulatory residue; other site 936156008043 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 936156008044 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 936156008045 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156008046 ABC-ATPase subunit interface; other site 936156008047 dimer interface [polypeptide binding]; other site 936156008048 putative PBP binding regions; other site 936156008049 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 936156008050 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156008051 ABC-ATPase subunit interface; other site 936156008052 dimer interface [polypeptide binding]; other site 936156008053 putative PBP binding regions; other site 936156008054 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 936156008055 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 936156008056 Walker A/P-loop; other site 936156008057 ATP binding site [chemical binding]; other site 936156008058 Q-loop/lid; other site 936156008059 ABC transporter signature motif; other site 936156008060 Walker B; other site 936156008061 D-loop; other site 936156008062 H-loop/switch region; other site 936156008063 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 936156008064 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 936156008065 putative ligand binding residues [chemical binding]; other site 936156008066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156008067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156008068 putative substrate translocation pore; other site 936156008069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156008070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156008071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156008072 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 936156008073 dimer interface [polypeptide binding]; other site 936156008074 FMN binding site [chemical binding]; other site 936156008075 NADPH bind site [chemical binding]; other site 936156008076 Uncharacterized conserved protein [Function unknown]; Region: COG1359 936156008077 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156008078 dimerization interface [polypeptide binding]; other site 936156008079 putative DNA binding site [nucleotide binding]; other site 936156008080 putative Zn2+ binding site [ion binding]; other site 936156008081 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 936156008082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156008083 DNA-binding site [nucleotide binding]; DNA binding site 936156008084 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156008085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156008086 homodimer interface [polypeptide binding]; other site 936156008087 catalytic residue [active] 936156008088 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 936156008089 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936156008090 inhibitor-cofactor binding pocket; inhibition site 936156008091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156008092 catalytic residue [active] 936156008093 succinic semialdehyde dehydrogenase; Region: PLN02278 936156008094 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 936156008095 tetramerization interface [polypeptide binding]; other site 936156008096 NAD(P) binding site [chemical binding]; other site 936156008097 catalytic residues [active] 936156008098 Sugar transport protein; Region: Sugar_transport; pfam06800 936156008099 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 936156008100 glucose-1-dehydrogenase; Provisional; Region: PRK08936 936156008101 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 936156008102 NAD binding site [chemical binding]; other site 936156008103 homodimer interface [polypeptide binding]; other site 936156008104 active site 936156008105 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 936156008106 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 936156008107 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 936156008108 YtkA-like; Region: YtkA; pfam13115 936156008109 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936156008110 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 936156008111 NosL; Region: NosL; cl01769 936156008112 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 936156008113 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 936156008114 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 936156008115 active site 936156008116 P-loop; other site 936156008117 phosphorylation site [posttranslational modification] 936156008118 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936156008119 active site 936156008120 phosphorylation site [posttranslational modification] 936156008121 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 936156008122 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 936156008123 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 936156008124 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 936156008125 tartrate dehydrogenase; Provisional; Region: PRK08194 936156008126 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 936156008127 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 936156008128 Catalytic site [active] 936156008129 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 936156008130 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 936156008131 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 936156008132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156008133 active site 936156008134 motif I; other site 936156008135 motif II; other site 936156008136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156008137 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 936156008138 putative active site [active] 936156008139 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 936156008140 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 936156008141 hypothetical protein; Provisional; Region: PRK05463 936156008142 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 936156008143 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 936156008144 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 936156008145 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 936156008146 Transcriptional regulator [Transcription]; Region: IclR; COG1414 936156008147 Bacterial transcriptional regulator; Region: IclR; pfam01614 936156008148 Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755 936156008149 active site 936156008150 catalytic triad [active] 936156008151 oxyanion hole [active] 936156008152 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 936156008153 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 936156008154 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 936156008155 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 936156008156 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 936156008157 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936156008158 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936156008159 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936156008160 active site 936156008161 catalytic tetrad [active] 936156008162 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 936156008163 HTH domain; Region: HTH_11; pfam08279 936156008164 PRD domain; Region: PRD; pfam00874 936156008165 PRD domain; Region: PRD; pfam00874 936156008166 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 936156008167 active site 936156008168 P-loop; other site 936156008169 phosphorylation site [posttranslational modification] 936156008170 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 936156008171 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 936156008172 acyl-activating enzyme (AAE) consensus motif; other site 936156008173 putative AMP binding site [chemical binding]; other site 936156008174 putative active site [active] 936156008175 putative CoA binding site [chemical binding]; other site 936156008176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156008177 S-adenosylmethionine binding site [chemical binding]; other site 936156008178 short chain dehydrogenase; Provisional; Region: PRK06701 936156008179 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 936156008180 NAD binding site [chemical binding]; other site 936156008181 metal binding site [ion binding]; metal-binding site 936156008182 active site 936156008183 ABC-type sugar transport system, auxiliary component [General function prediction only]; Region: COG3822 936156008184 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 936156008185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 936156008186 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 936156008187 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 936156008188 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 936156008189 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 936156008190 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 936156008191 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 936156008192 putative DNA binding site [nucleotide binding]; other site 936156008193 putative Zn2+ binding site [ion binding]; other site 936156008194 AsnC family; Region: AsnC_trans_reg; pfam01037 936156008195 DNA topoisomerase III; Provisional; Region: PRK07726 936156008196 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 936156008197 active site 936156008198 putative interdomain interaction site [polypeptide binding]; other site 936156008199 putative metal-binding site [ion binding]; other site 936156008200 putative nucleotide binding site [chemical binding]; other site 936156008201 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 936156008202 domain I; other site 936156008203 DNA binding groove [nucleotide binding] 936156008204 phosphate binding site [ion binding]; other site 936156008205 domain II; other site 936156008206 domain III; other site 936156008207 nucleotide binding site [chemical binding]; other site 936156008208 catalytic site [active] 936156008209 domain IV; other site 936156008210 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 936156008211 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 936156008212 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 936156008213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936156008214 metal binding site [ion binding]; metal-binding site 936156008215 active site 936156008216 I-site; other site 936156008217 potential frameshift: common BLAST hit: gi|52787911|ref|YP_093740.1| YdaL 936156008218 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 936156008219 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 936156008220 DXD motif; other site 936156008221 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 936156008222 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 936156008223 Amino acid permease; Region: AA_permease_2; pfam13520 936156008224 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 936156008225 nudix motif; other site 936156008226 pyruvate oxidase; Provisional; Region: PRK08611 936156008227 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 936156008228 PYR/PP interface [polypeptide binding]; other site 936156008229 tetramer interface [polypeptide binding]; other site 936156008230 dimer interface [polypeptide binding]; other site 936156008231 TPP binding site [chemical binding]; other site 936156008232 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 936156008233 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 936156008234 TPP-binding site [chemical binding]; other site 936156008235 manganese transport protein MntH; Reviewed; Region: PRK00701 936156008236 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 936156008237 Predicted membrane protein [Function unknown]; Region: COG2261 936156008238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 936156008239 EcsC protein family; Region: EcsC; pfam12787 936156008240 General stress protein [General function prediction only]; Region: GsiB; COG3729 936156008241 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 936156008242 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 936156008243 dimanganese center [ion binding]; other site 936156008244 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 936156008245 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 936156008246 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 936156008247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156008248 putative active site [active] 936156008249 heme pocket [chemical binding]; other site 936156008250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156008251 ATP binding site [chemical binding]; other site 936156008252 Mg2+ binding site [ion binding]; other site 936156008253 G-X-G motif; other site 936156008254 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 936156008255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156008256 active site 936156008257 phosphorylation site [posttranslational modification] 936156008258 intermolecular recognition site; other site 936156008259 dimerization interface [polypeptide binding]; other site 936156008260 HTH domain; Region: HTH_11; cl17392 936156008261 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 936156008262 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 936156008263 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 936156008264 Domain of unknown function DUF20; Region: UPF0118; pfam01594 936156008265 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 936156008266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936156008267 Walker A/P-loop; other site 936156008268 ATP binding site [chemical binding]; other site 936156008269 Q-loop/lid; other site 936156008270 ABC transporter signature motif; other site 936156008271 Walker B; other site 936156008272 D-loop; other site 936156008273 H-loop/switch region; other site 936156008274 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 936156008275 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 936156008276 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 936156008277 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 936156008278 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 936156008279 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 936156008280 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 936156008281 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 936156008282 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 936156008283 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 936156008284 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 936156008285 catalytic residues [active] 936156008286 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 936156008287 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 936156008288 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 936156008289 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 936156008290 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 936156008291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936156008292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936156008293 helicase 45; Provisional; Region: PTZ00424 936156008294 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 936156008295 ATP binding site [chemical binding]; other site 936156008296 Mg++ binding site [ion binding]; other site 936156008297 motif III; other site 936156008298 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156008299 nucleotide binding region [chemical binding]; other site 936156008300 ATP-binding site [chemical binding]; other site 936156008301 Uncharacterized conserved protein [Function unknown]; Region: COG3402 936156008302 Predicted membrane protein [Function unknown]; Region: COG3428 936156008303 Bacterial PH domain; Region: DUF304; pfam03703 936156008304 Bacterial PH domain; Region: DUF304; pfam03703 936156008305 Bacterial PH domain; Region: DUF304; pfam03703 936156008306 Rhomboid family; Region: Rhomboid; pfam01694 936156008307 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 936156008308 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 936156008309 alanine racemase; Region: alr; TIGR00492 936156008310 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 936156008311 active site 936156008312 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936156008313 dimer interface [polypeptide binding]; other site 936156008314 substrate binding site [chemical binding]; other site 936156008315 catalytic residues [active] 936156008316 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 936156008317 ribbon-helix-helix domain containing protein; Region: PHA00617 936156008318 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 936156008319 Rsbr N terminal; Region: Rsbr_N; pfam08678 936156008320 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 936156008321 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 936156008322 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 936156008323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156008324 ATP binding site [chemical binding]; other site 936156008325 Mg2+ binding site [ion binding]; other site 936156008326 G-X-G motif; other site 936156008327 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 936156008328 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 936156008329 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 936156008330 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 936156008331 anti sigma factor interaction site; other site 936156008332 regulatory phosphorylation site [posttranslational modification]; other site 936156008333 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 936156008334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156008335 ATP binding site [chemical binding]; other site 936156008336 Mg2+ binding site [ion binding]; other site 936156008337 G-X-G motif; other site 936156008338 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 936156008339 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156008340 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 936156008341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156008342 DNA binding residues [nucleotide binding] 936156008343 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 936156008344 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 936156008345 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 936156008346 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 936156008347 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 936156008348 RNA binding site [nucleotide binding]; other site 936156008349 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 936156008350 hypothetical protein; Provisional; Region: PRK04351 936156008351 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 936156008352 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936156008353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156008354 non-specific DNA binding site [nucleotide binding]; other site 936156008355 salt bridge; other site 936156008356 sequence-specific DNA binding site [nucleotide binding]; other site 936156008357 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 936156008358 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 936156008359 conserved cys residue [active] 936156008360 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 936156008361 DNA-binding site [nucleotide binding]; DNA binding site 936156008362 RNA-binding motif; other site 936156008363 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 936156008364 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 936156008365 EamA-like transporter family; Region: EamA; pfam00892 936156008366 EamA-like transporter family; Region: EamA; pfam00892 936156008367 Cupin domain; Region: Cupin_2; pfam07883 936156008368 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936156008369 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156008370 EamA-like transporter family; Region: EamA; pfam00892 936156008371 EamA-like transporter family; Region: EamA; pfam00892 936156008372 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936156008373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156008374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 936156008375 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 936156008376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156008377 DNA-binding site [nucleotide binding]; DNA binding site 936156008378 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156008379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156008380 homodimer interface [polypeptide binding]; other site 936156008381 catalytic residue [active] 936156008382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156008383 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156008384 putative substrate translocation pore; other site 936156008385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 936156008386 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 936156008387 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 936156008388 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 936156008389 dimerization domain swap beta strand [polypeptide binding]; other site 936156008390 regulatory protein interface [polypeptide binding]; other site 936156008391 regulatory phosphorylation site [posttranslational modification]; other site 936156008392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156008393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156008394 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 936156008395 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 936156008396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156008397 DNA-binding site [nucleotide binding]; DNA binding site 936156008398 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156008399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156008400 homodimer interface [polypeptide binding]; other site 936156008401 catalytic residue [active] 936156008402 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 936156008403 putative active site [active] 936156008404 putative catalytic site [active] 936156008405 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 936156008406 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 936156008407 Predicted transcriptional regulators [Transcription]; Region: COG1733 936156008408 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 936156008409 Uncharacterized conserved protein [Function unknown]; Region: COG1284 936156008410 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156008411 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156008412 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 936156008413 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936156008414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156008415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156008416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156008417 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156008418 dimerization interface [polypeptide binding]; other site 936156008419 putative DNA binding site [nucleotide binding]; other site 936156008420 putative Zn2+ binding site [ion binding]; other site 936156008421 arsenical pump membrane protein; Provisional; Region: PRK15445 936156008422 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 936156008423 transmembrane helices; other site 936156008424 Low molecular weight phosphatase family; Region: LMWPc; cl00105 936156008425 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 936156008426 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 936156008427 EamA-like transporter family; Region: EamA; pfam00892 936156008428 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 936156008429 EamA-like transporter family; Region: EamA; pfam00892 936156008430 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 936156008431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156008432 DNA-binding site [nucleotide binding]; DNA binding site 936156008433 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156008434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156008435 homodimer interface [polypeptide binding]; other site 936156008436 catalytic residue [active] 936156008437 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 936156008438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156008439 putative DNA binding site [nucleotide binding]; other site 936156008440 putative Zn2+ binding site [ion binding]; other site 936156008441 Uncharacterized conserved protein [Function unknown]; Region: COG2128 936156008442 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 936156008443 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 936156008444 Histidine kinase; Region: HisKA_3; pfam07730 936156008445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156008446 ATP binding site [chemical binding]; other site 936156008447 Mg2+ binding site [ion binding]; other site 936156008448 G-X-G motif; other site 936156008449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936156008450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156008451 active site 936156008452 phosphorylation site [posttranslational modification] 936156008453 intermolecular recognition site; other site 936156008454 dimerization interface [polypeptide binding]; other site 936156008455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936156008456 DNA binding residues [nucleotide binding] 936156008457 dimerization interface [polypeptide binding]; other site 936156008458 MMPL family; Region: MMPL; pfam03176 936156008459 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 936156008460 MMPL family; Region: MMPL; pfam03176 936156008461 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 936156008462 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 936156008463 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 936156008464 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 936156008465 DNA binding residues [nucleotide binding] 936156008466 drug binding residues [chemical binding]; other site 936156008467 dimer interface [polypeptide binding]; other site 936156008468 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 936156008469 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 936156008470 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 936156008471 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 936156008472 dimer interface [polypeptide binding]; other site 936156008473 FMN binding site [chemical binding]; other site 936156008474 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 936156008475 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156008476 Zn binding site [ion binding]; other site 936156008477 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 936156008478 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156008479 Zn binding site [ion binding]; other site 936156008480 Predicted membrane protein [Function unknown]; Region: COG2259 936156008481 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 936156008482 catalytic residues [active] 936156008483 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 936156008484 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 936156008485 Predicted membrane protein [Function unknown]; Region: COG2323 936156008486 Predicted membrane protein [Function unknown]; Region: COG2323 936156008487 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 936156008488 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 936156008489 putative dimer interface [polypeptide binding]; other site 936156008490 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 936156008491 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 936156008492 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156008493 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156008494 DoxX-like family; Region: DoxX_2; pfam13564 936156008495 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 936156008496 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936156008497 ABC transporter; Region: ABC_tran_2; pfam12848 936156008498 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936156008499 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 936156008500 DinB family; Region: DinB; pfam05163 936156008501 DinB superfamily; Region: DinB_2; pfam12867 936156008502 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156008503 MarR family; Region: MarR; pfam01047 936156008504 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 936156008505 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 936156008506 dimer interface [polypeptide binding]; other site 936156008507 FMN binding site [chemical binding]; other site 936156008508 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156008509 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156008510 putative DNA binding site [nucleotide binding]; other site 936156008511 putative Zn2+ binding site [ion binding]; other site 936156008512 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 936156008513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156008514 putative substrate translocation pore; other site 936156008515 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 936156008516 Transcriptional regulators [Transcription]; Region: GntR; COG1802 936156008517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156008518 DNA-binding site [nucleotide binding]; DNA binding site 936156008519 FCD domain; Region: FCD; pfam07729 936156008520 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 936156008521 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156008522 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156008523 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 936156008524 active site 936156008525 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 936156008526 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 936156008527 homodimer interface [polypeptide binding]; other site 936156008528 active site 936156008529 TDP-binding site; other site 936156008530 acceptor substrate-binding pocket; other site 936156008531 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 936156008532 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 936156008533 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 936156008534 dimer interface [polypeptide binding]; other site 936156008535 active site 936156008536 Uncharacterized conserved protein [Function unknown]; Region: COG5646 936156008537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156008538 Coenzyme A binding pocket [chemical binding]; other site 936156008539 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 936156008540 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936156008541 Zn2+ binding site [ion binding]; other site 936156008542 Mg2+ binding site [ion binding]; other site 936156008543 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 936156008544 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 936156008545 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936156008546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156008547 putative substrate translocation pore; other site 936156008548 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 936156008549 active site 936156008550 P-loop; other site 936156008551 phosphorylation site [posttranslational modification] 936156008552 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 936156008553 active site 936156008554 methionine cluster; other site 936156008555 phosphorylation site [posttranslational modification] 936156008556 metal binding site [ion binding]; metal-binding site 936156008557 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 936156008558 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 936156008559 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 936156008560 beta-galactosidase; Region: BGL; TIGR03356 936156008561 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 936156008562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156008563 DNA-binding site [nucleotide binding]; DNA binding site 936156008564 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 936156008565 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 936156008566 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936156008567 nucleotide binding site [chemical binding]; other site 936156008568 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 936156008569 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 936156008570 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 936156008571 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 936156008572 dimanganese center [ion binding]; other site 936156008573 thiamine-monophosphate kinase; Region: thiL; TIGR01379 936156008574 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 936156008575 ATP binding site [chemical binding]; other site 936156008576 dimerization interface [polypeptide binding]; other site 936156008577 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 936156008578 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 936156008579 Glycoprotease family; Region: Peptidase_M22; pfam00814 936156008580 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 936156008581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156008582 Coenzyme A binding pocket [chemical binding]; other site 936156008583 UGMP family protein; Validated; Region: PRK09604 936156008584 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936156008585 nucleotide binding site [chemical binding]; other site 936156008586 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 936156008587 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936156008588 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936156008589 ABC transporter; Region: ABC_tran_2; pfam12848 936156008590 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936156008591 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 936156008592 trimer interface [polypeptide binding]; other site 936156008593 dimer interface [polypeptide binding]; other site 936156008594 putative active site [active] 936156008595 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 936156008596 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 936156008597 CoA binding domain; Region: CoA_binding; pfam02629 936156008598 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 936156008599 Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945 936156008600 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 936156008601 CAAX protease self-immunity; Region: Abi; pfam02517 936156008602 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 936156008603 oligomerisation interface [polypeptide binding]; other site 936156008604 mobile loop; other site 936156008605 roof hairpin; other site 936156008606 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 936156008607 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 936156008608 ring oligomerisation interface [polypeptide binding]; other site 936156008609 ATP/Mg binding site [chemical binding]; other site 936156008610 stacking interactions; other site 936156008611 hinge regions; other site 936156008612 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 936156008613 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 936156008614 Int/Topo IB signature motif; other site 936156008615 Domain of unknown function (DUF955); Region: DUF955; pfam06114 936156008616 Short C-terminal domain; Region: SHOCT; pfam09851 936156008617 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936156008618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156008619 non-specific DNA binding site [nucleotide binding]; other site 936156008620 salt bridge; other site 936156008621 sequence-specific DNA binding site [nucleotide binding]; other site 936156008622 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936156008623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156008624 non-specific DNA binding site [nucleotide binding]; other site 936156008625 salt bridge; other site 936156008626 sequence-specific DNA binding site [nucleotide binding]; other site 936156008627 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 936156008628 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 936156008629 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 936156008630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156008631 non-specific DNA binding site [nucleotide binding]; other site 936156008632 salt bridge; other site 936156008633 sequence-specific DNA binding site [nucleotide binding]; other site 936156008634 Hypothetical protein Yqai; Region: Yqai; pfam09466 936156008635 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 936156008636 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156008637 putative DNA binding site [nucleotide binding]; other site 936156008638 putative Zn2+ binding site [ion binding]; other site 936156008639 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 936156008640 hypothetical protein; Provisional; Region: PRK06921 936156008641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156008642 Walker A motif; other site 936156008643 ATP binding site [chemical binding]; other site 936156008644 Walker B motif; other site 936156008645 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 936156008646 Helix-turn-helix domain; Region: HTH_17; cl17695 936156008647 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 936156008648 peptide chain release factor 1; Provisional; Region: PRK04011 936156008649 YopX protein; Region: YopX; pfam09643 936156008650 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 936156008651 positive control sigma-like factor; Validated; Region: PRK06930 936156008652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156008653 DNA binding residues [nucleotide binding] 936156008654 Helix-turn-helix domain; Region: HTH_17; pfam12728 936156008655 Uncharacterized conserved protein [Function unknown]; Region: COG5484 936156008656 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 936156008657 Phage terminase large subunit; Region: Terminase_3; cl12054 936156008658 Terminase-like family; Region: Terminase_6; pfam03237 936156008659 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 936156008660 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 936156008661 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 936156008662 Phage capsid family; Region: Phage_capsid; pfam05065 936156008663 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 936156008664 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 936156008665 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 936156008666 Phage-related protein [Function unknown]; Region: COG5412 936156008667 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 936156008668 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936156008669 catalytic residue [active] 936156008670 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156008671 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 936156008672 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 936156008673 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 936156008674 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 936156008675 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 936156008676 active site 936156008677 catalytic site [active] 936156008678 Haemolysin XhlA; Region: XhlA; pfam10779 936156008679 holin, SPP1 family; Region: holin_SPP1; TIGR01592 936156008680 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 936156008681 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 936156008682 amidase catalytic site [active] 936156008683 Zn binding residues [ion binding]; other site 936156008684 substrate binding site [chemical binding]; other site 936156008685 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 936156008686 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 936156008687 Helix-turn-helix domain; Region: HTH_17; pfam12728 936156008688 SecA binding site; other site 936156008689 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 936156008690 Preprotein binding site; other site 936156008691 PGAP1-like protein; Region: PGAP1; pfam07819 936156008692 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 936156008693 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 936156008694 NB-ARC domain; Region: NB-ARC; pfam00931 936156008695 TPR repeat; Region: TPR_11; pfam13414 936156008696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156008697 TPR motif; other site 936156008698 TPR repeat; Region: TPR_11; pfam13414 936156008699 binding surface 936156008700 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 936156008701 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 936156008702 inhibitor binding site; inhibition site 936156008703 catalytic Zn binding site [ion binding]; other site 936156008704 structural Zn binding site [ion binding]; other site 936156008705 NADP binding site [chemical binding]; other site 936156008706 tetramer interface [polypeptide binding]; other site 936156008707 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 936156008708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156008709 putative substrate translocation pore; other site 936156008710 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936156008711 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 936156008712 putative substrate binding site [chemical binding]; other site 936156008713 putative ATP binding site [chemical binding]; other site 936156008714 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 936156008715 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 936156008716 DNA-directed RNA polymerase subunit F; Provisional; Region: PRK14981 936156008717 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 936156008718 Repair protein; Region: Repair_PSII; pfam04536 936156008719 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 936156008720 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 936156008721 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 936156008722 Double zinc ribbon; Region: DZR; pfam12773 936156008723 Ion channel; Region: Ion_trans_2; pfam07885 936156008724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156008725 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 936156008726 putative substrate translocation pore; other site 936156008727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156008728 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 936156008729 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 936156008730 putative NAD(P) binding site [chemical binding]; other site 936156008731 catalytic Zn binding site [ion binding]; other site 936156008732 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 936156008733 Cold-inducible protein YdjO; Region: YdjO; pfam14169 936156008734 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 936156008735 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 936156008736 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 936156008737 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 936156008738 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 936156008739 Multicopper oxidase; Region: Cu-oxidase; pfam00394 936156008740 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 936156008741 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 936156008742 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 936156008743 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 936156008744 MoxR-like ATPases [General function prediction only]; Region: COG0714 936156008745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156008746 Walker A motif; other site 936156008747 ATP binding site [chemical binding]; other site 936156008748 Walker B motif; other site 936156008749 arginine finger; other site 936156008750 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 936156008751 Protein of unknown function DUF58; Region: DUF58; pfam01882 936156008752 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 936156008753 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 936156008754 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 936156008755 GMP synthase; Reviewed; Region: guaA; PRK00074 936156008756 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 936156008757 AMP/PPi binding site [chemical binding]; other site 936156008758 candidate oxyanion hole; other site 936156008759 catalytic triad [active] 936156008760 potential glutamine specificity residues [chemical binding]; other site 936156008761 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 936156008762 ATP Binding subdomain [chemical binding]; other site 936156008763 Ligand Binding sites [chemical binding]; other site 936156008764 Dimerization subdomain; other site 936156008765 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 936156008766 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156008767 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156008768 DNA binding residues [nucleotide binding] 936156008769 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 936156008770 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 936156008771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 936156008772 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 936156008773 NETI protein; Region: NETI; pfam14044 936156008774 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 936156008775 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 936156008776 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 936156008777 NAD binding site [chemical binding]; other site 936156008778 ATP-grasp domain; Region: ATP-grasp; pfam02222 936156008779 adenylosuccinate lyase; Provisional; Region: PRK07492 936156008780 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 936156008781 tetramer interface [polypeptide binding]; other site 936156008782 active site 936156008783 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 936156008784 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 936156008785 ATP binding site [chemical binding]; other site 936156008786 active site 936156008787 substrate binding site [chemical binding]; other site 936156008788 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 936156008789 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 936156008790 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 936156008791 putative active site [active] 936156008792 catalytic triad [active] 936156008793 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 936156008794 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 936156008795 dimerization interface [polypeptide binding]; other site 936156008796 ATP binding site [chemical binding]; other site 936156008797 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 936156008798 dimerization interface [polypeptide binding]; other site 936156008799 ATP binding site [chemical binding]; other site 936156008800 amidophosphoribosyltransferase; Provisional; Region: PRK07631 936156008801 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 936156008802 active site 936156008803 tetramer interface [polypeptide binding]; other site 936156008804 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936156008805 active site 936156008806 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 936156008807 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 936156008808 dimerization interface [polypeptide binding]; other site 936156008809 putative ATP binding site [chemical binding]; other site 936156008810 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 936156008811 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 936156008812 active site 936156008813 substrate binding site [chemical binding]; other site 936156008814 cosubstrate binding site; other site 936156008815 catalytic site [active] 936156008816 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 936156008817 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 936156008818 purine monophosphate binding site [chemical binding]; other site 936156008819 dimer interface [polypeptide binding]; other site 936156008820 putative catalytic residues [active] 936156008821 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 936156008822 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 936156008823 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 936156008824 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 936156008825 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 936156008826 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 936156008827 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 936156008828 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156008829 putative DNA binding site [nucleotide binding]; other site 936156008830 putative Zn2+ binding site [ion binding]; other site 936156008831 AsnC family; Region: AsnC_trans_reg; pfam01037 936156008832 putative transporter; Provisional; Region: PRK11021 936156008833 Spore germination protein; Region: Spore_permease; cl17796 936156008834 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 936156008835 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 936156008836 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 936156008837 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 936156008838 active site 936156008839 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 936156008840 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 936156008841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 936156008842 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 936156008843 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 936156008844 active site 936156008845 FMN binding site [chemical binding]; other site 936156008846 substrate binding site [chemical binding]; other site 936156008847 3Fe-4S cluster binding site [ion binding]; other site 936156008848 PcrB family; Region: PcrB; pfam01884 936156008849 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 936156008850 substrate binding site [chemical binding]; other site 936156008851 putative active site [active] 936156008852 dimer interface [polypeptide binding]; other site 936156008853 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 936156008854 Part of AAA domain; Region: AAA_19; pfam13245 936156008855 Family description; Region: UvrD_C_2; pfam13538 936156008856 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 936156008857 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 936156008858 nucleotide binding pocket [chemical binding]; other site 936156008859 K-X-D-G motif; other site 936156008860 catalytic site [active] 936156008861 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 936156008862 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 936156008863 Helix-hairpin-helix motif; Region: HHH; pfam00633 936156008864 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 936156008865 Dimer interface [polypeptide binding]; other site 936156008866 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 936156008867 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 936156008868 putative dimer interface [polypeptide binding]; other site 936156008869 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 936156008870 putative dimer interface [polypeptide binding]; other site 936156008871 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 936156008872 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 936156008873 active site 936156008874 ATP binding site [chemical binding]; other site 936156008875 substrate binding site [chemical binding]; other site 936156008876 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 936156008877 MgtC family; Region: MgtC; pfam02308 936156008878 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 936156008879 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 936156008880 Na binding site [ion binding]; other site 936156008881 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 936156008882 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 936156008883 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 936156008884 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 936156008885 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 936156008886 GatB domain; Region: GatB_Yqey; pfam02637 936156008887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156008888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156008889 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 936156008890 Protein export membrane protein; Region: SecD_SecF; cl14618 936156008891 Protein export membrane protein; Region: SecD_SecF; cl14618 936156008892 putative lipid kinase; Reviewed; Region: PRK13337 936156008893 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 936156008894 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 936156008895 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 936156008896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156008897 S-adenosylmethionine binding site [chemical binding]; other site 936156008898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156008899 binding surface 936156008900 TPR motif; other site 936156008901 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156008902 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156008903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156008904 TPR motif; other site 936156008905 binding surface 936156008906 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156008907 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 936156008908 LXG domain of WXG superfamily; Region: LXG; pfam04740 936156008909 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156008910 hypothetical protein; Provisional; Region: PRK12378 936156008911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156008912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156008913 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 936156008914 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 936156008915 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 936156008916 NADP binding site [chemical binding]; other site 936156008917 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 936156008918 CotJB protein; Region: CotJB; pfam12652 936156008919 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 936156008920 dimanganese center [ion binding]; other site 936156008921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156008922 Coenzyme A binding pocket [chemical binding]; other site 936156008923 YesK-like protein; Region: YesK; pfam14150 936156008924 Predicted integral membrane protein [Function unknown]; Region: COG5578 936156008925 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 936156008926 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 936156008927 dimerization interface [polypeptide binding]; other site 936156008928 Histidine kinase; Region: His_kinase; pfam06580 936156008929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156008930 ATP binding site [chemical binding]; other site 936156008931 Mg2+ binding site [ion binding]; other site 936156008932 G-X-G motif; other site 936156008933 Response regulator receiver domain; Region: Response_reg; pfam00072 936156008934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156008935 active site 936156008936 phosphorylation site [posttranslational modification] 936156008937 intermolecular recognition site; other site 936156008938 dimerization interface [polypeptide binding]; other site 936156008939 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936156008940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156008941 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 936156008942 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 936156008943 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 936156008944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156008945 dimer interface [polypeptide binding]; other site 936156008946 conserved gate region; other site 936156008947 putative PBP binding loops; other site 936156008948 ABC-ATPase subunit interface; other site 936156008949 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 936156008950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156008951 dimer interface [polypeptide binding]; other site 936156008952 conserved gate region; other site 936156008953 putative PBP binding loops; other site 936156008954 ABC-ATPase subunit interface; other site 936156008955 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 936156008956 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936156008957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156008958 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 936156008959 active site 936156008960 catalytic triad [active] 936156008961 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 936156008962 Predicted integral membrane protein [Function unknown]; Region: COG5578 936156008963 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 936156008964 metal binding site [ion binding]; metal-binding site 936156008965 active site 936156008966 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 936156008967 metal binding site [ion binding]; metal-binding site 936156008968 active site 936156008969 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 936156008970 active site 936156008971 catalytic triad [active] 936156008972 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 936156008973 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 936156008974 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 936156008975 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 936156008976 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 936156008977 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 936156008978 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 936156008979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156008980 dimer interface [polypeptide binding]; other site 936156008981 putative PBP binding loops; other site 936156008982 ABC-ATPase subunit interface; other site 936156008983 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 936156008984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156008985 dimer interface [polypeptide binding]; other site 936156008986 conserved gate region; other site 936156008987 putative PBP binding loops; other site 936156008988 ABC-ATPase subunit interface; other site 936156008989 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 936156008990 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 936156008991 NAD(P) binding site [chemical binding]; other site 936156008992 LDH/MDH dimer interface [polypeptide binding]; other site 936156008993 substrate binding site [chemical binding]; other site 936156008994 Predicted membrane protein [Function unknown]; Region: COG2323 936156008995 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 936156008996 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156008997 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 936156008998 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 936156008999 Uncharacterized small protein [Function unknown]; Region: COG5583 936156009000 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 936156009001 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 936156009002 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156009003 MarR family; Region: MarR; pfam01047 936156009004 hypothetical protein; Provisional; Region: PRK06847 936156009005 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 936156009006 Excalibur calcium-binding domain; Region: Excalibur; smart00894 936156009007 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 936156009008 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 936156009009 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 936156009010 Cytochrome P450; Region: p450; pfam00067 936156009011 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 936156009012 Flavodoxin; Region: Flavodoxin_1; pfam00258 936156009013 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 936156009014 FAD binding pocket [chemical binding]; other site 936156009015 FAD binding motif [chemical binding]; other site 936156009016 catalytic residues [active] 936156009017 NAD binding pocket [chemical binding]; other site 936156009018 phosphate binding motif [ion binding]; other site 936156009019 beta-alpha-beta structure motif; other site 936156009020 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 936156009021 Sulfatase; Region: Sulfatase; pfam00884 936156009022 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 936156009023 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 936156009024 substrate binding site; other site 936156009025 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 936156009026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 936156009027 NAD(P) binding site [chemical binding]; other site 936156009028 active site 936156009029 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 936156009030 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 936156009031 active site 936156009032 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 936156009033 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 936156009034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156009035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156009036 putative substrate translocation pore; other site 936156009037 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 936156009038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156009039 active site 936156009040 motif I; other site 936156009041 motif II; other site 936156009042 amino acid transporter; Region: 2A0306; TIGR00909 936156009043 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 936156009044 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 936156009045 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 936156009046 NAD(P) binding site [chemical binding]; other site 936156009047 catalytic residues [active] 936156009048 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 936156009049 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936156009050 dimer interface [polypeptide binding]; other site 936156009051 putative CheW interface [polypeptide binding]; other site 936156009052 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 936156009053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936156009054 Walker A/P-loop; other site 936156009055 ATP binding site [chemical binding]; other site 936156009056 Q-loop/lid; other site 936156009057 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936156009058 ABC transporter signature motif; other site 936156009059 Walker B; other site 936156009060 D-loop; other site 936156009061 ABC transporter; Region: ABC_tran_2; pfam12848 936156009062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936156009063 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 936156009064 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 936156009065 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 936156009066 DNA binding residues [nucleotide binding] 936156009067 putative dimer interface [polypeptide binding]; other site 936156009068 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936156009069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156009070 putative substrate translocation pore; other site 936156009071 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 936156009072 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936156009073 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936156009074 ABC transporter; Region: ABC_tran_2; pfam12848 936156009075 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936156009076 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 936156009077 DEAD-like helicases superfamily; Region: DEXDc; smart00487 936156009078 ATP binding site [chemical binding]; other site 936156009079 Mg++ binding site [ion binding]; other site 936156009080 motif III; other site 936156009081 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156009082 nucleotide binding region [chemical binding]; other site 936156009083 ATP-binding site [chemical binding]; other site 936156009084 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 936156009085 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 936156009086 Coenzyme A binding pocket [chemical binding]; other site 936156009087 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 936156009088 Prostaglandin dehydrogenases; Region: PGDH; cd05288 936156009089 NAD(P) binding site [chemical binding]; other site 936156009090 substrate binding site [chemical binding]; other site 936156009091 dimer interface [polypeptide binding]; other site 936156009092 H+ Antiporter protein; Region: 2A0121; TIGR00900 936156009093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156009094 Uncharacterized conserved protein [Function unknown]; Region: COG1262 936156009095 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 936156009096 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 936156009097 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 936156009098 Walker A/P-loop; other site 936156009099 ATP binding site [chemical binding]; other site 936156009100 Q-loop/lid; other site 936156009101 ABC transporter signature motif; other site 936156009102 Walker B; other site 936156009103 D-loop; other site 936156009104 H-loop/switch region; other site 936156009105 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 936156009106 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156009107 ABC-ATPase subunit interface; other site 936156009108 dimer interface [polypeptide binding]; other site 936156009109 putative PBP binding regions; other site 936156009110 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 936156009111 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156009112 ABC-ATPase subunit interface; other site 936156009113 dimer interface [polypeptide binding]; other site 936156009114 putative PBP binding regions; other site 936156009115 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 936156009116 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 936156009117 siderophore binding site; other site 936156009118 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 936156009119 Heat induced stress protein YflT; Region: YflT; pfam11181 936156009120 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 936156009121 Amb_all domain; Region: Amb_all; smart00656 936156009122 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 936156009123 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 936156009124 transmembrane helices; other site 936156009125 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 936156009126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156009127 ATP binding site [chemical binding]; other site 936156009128 Mg2+ binding site [ion binding]; other site 936156009129 G-X-G motif; other site 936156009130 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 936156009131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156009132 active site 936156009133 phosphorylation site [posttranslational modification] 936156009134 intermolecular recognition site; other site 936156009135 dimerization interface [polypeptide binding]; other site 936156009136 Transcriptional regulator; Region: CitT; pfam12431 936156009137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 936156009138 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 936156009139 Citrate transporter; Region: CitMHS; pfam03600 936156009140 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 936156009141 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 936156009142 active site 936156009143 dimer interface [polypeptide binding]; other site 936156009144 acylphosphatase; Provisional; Region: PRK14420 936156009145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 936156009146 MOSC domain; Region: MOSC; pfam03473 936156009147 3-alpha domain; Region: 3-alpha; pfam03475 936156009148 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 936156009149 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 936156009150 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 936156009151 active site 936156009152 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 936156009153 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 936156009154 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 936156009155 active site turn [active] 936156009156 phosphorylation site [posttranslational modification] 936156009157 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 936156009158 Sulfatase; Region: Sulfatase; pfam00884 936156009159 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 936156009160 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 936156009161 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 936156009162 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 936156009163 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 936156009164 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 936156009165 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 936156009166 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 936156009167 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 936156009168 active site turn [active] 936156009169 phosphorylation site [posttranslational modification] 936156009170 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 936156009171 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 936156009172 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 936156009173 Ca binding site [ion binding]; other site 936156009174 active site 936156009175 catalytic site [active] 936156009176 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 936156009177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156009178 DNA-binding site [nucleotide binding]; DNA binding site 936156009179 UTRA domain; Region: UTRA; pfam07702 936156009180 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 936156009181 dimer interface [polypeptide binding]; other site 936156009182 FMN binding site [chemical binding]; other site 936156009183 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 936156009184 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 936156009185 active site 936156009186 metal binding site [ion binding]; metal-binding site 936156009187 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 936156009188 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 936156009189 active site 936156009190 metal binding site [ion binding]; metal-binding site 936156009191 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 936156009192 intracellular protease, PfpI family; Region: PfpI; TIGR01382 936156009193 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 936156009194 proposed catalytic triad [active] 936156009195 conserved cys residue [active] 936156009196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156009197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156009198 putative substrate translocation pore; other site 936156009199 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 936156009200 Low molecular weight phosphatase family; Region: LMWPc; cd00115 936156009201 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 936156009202 active site 936156009203 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 936156009204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156009205 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156009206 putative substrate translocation pore; other site 936156009207 calcium/proton exchanger (cax); Region: cax; TIGR00378 936156009208 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 936156009209 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 936156009210 YfkD-like protein; Region: YfkD; pfam14167 936156009211 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 936156009212 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936156009213 Radical SAM superfamily; Region: Radical_SAM; pfam04055 936156009214 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936156009215 FeS/SAM binding site; other site 936156009216 YfkB-like domain; Region: YfkB; pfam08756 936156009217 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 936156009218 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 936156009219 NodB motif; other site 936156009220 active site 936156009221 catalytic site [active] 936156009222 Cd binding site [ion binding]; other site 936156009223 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 936156009224 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 936156009225 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 936156009226 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 936156009227 oligomer interface [polypeptide binding]; other site 936156009228 metal binding site [ion binding]; metal-binding site 936156009229 metal binding site [ion binding]; metal-binding site 936156009230 putative Cl binding site [ion binding]; other site 936156009231 aspartate ring; other site 936156009232 basic sphincter; other site 936156009233 hydrophobic gate; other site 936156009234 periplasmic entrance; other site 936156009235 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 936156009236 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 936156009237 minor groove reading motif; other site 936156009238 helix-hairpin-helix signature motif; other site 936156009239 substrate binding pocket [chemical binding]; other site 936156009240 active site 936156009241 TRAM domain; Region: TRAM; pfam01938 936156009242 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 936156009243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156009244 S-adenosylmethionine binding site [chemical binding]; other site 936156009245 YfzA-like protein; Region: YfzA; pfam14118 936156009246 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 936156009247 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 936156009248 FMN binding site [chemical binding]; other site 936156009249 active site 936156009250 catalytic residues [active] 936156009251 substrate binding site [chemical binding]; other site 936156009252 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 936156009253 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 936156009254 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 936156009255 tetramer interface [polypeptide binding]; other site 936156009256 TPP-binding site [chemical binding]; other site 936156009257 heterodimer interface [polypeptide binding]; other site 936156009258 phosphorylation loop region [posttranslational modification] 936156009259 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 936156009260 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 936156009261 alpha subunit interface [polypeptide binding]; other site 936156009262 TPP binding site [chemical binding]; other site 936156009263 heterodimer interface [polypeptide binding]; other site 936156009264 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 936156009265 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 936156009266 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 936156009267 E3 interaction surface; other site 936156009268 lipoyl attachment site [posttranslational modification]; other site 936156009269 e3 binding domain; Region: E3_binding; pfam02817 936156009270 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 936156009271 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 936156009272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936156009273 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 936156009274 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 936156009275 GAF domain; Region: GAF; pfam01590 936156009276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156009277 Walker A motif; other site 936156009278 ATP binding site [chemical binding]; other site 936156009279 Walker B motif; other site 936156009280 arginine finger; other site 936156009281 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 936156009282 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 936156009283 hypothetical protein; Provisional; Region: PRK02237 936156009284 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 936156009285 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 936156009286 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 936156009287 NAD binding site [chemical binding]; other site 936156009288 sugar binding site [chemical binding]; other site 936156009289 divalent metal binding site [ion binding]; other site 936156009290 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 936156009291 dimer interface [polypeptide binding]; other site 936156009292 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 936156009293 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 936156009294 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 936156009295 putative active site [active] 936156009296 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 936156009297 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 936156009298 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 936156009299 active site turn [active] 936156009300 phosphorylation site [posttranslational modification] 936156009301 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 936156009302 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936156009303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936156009304 Walker A/P-loop; other site 936156009305 ATP binding site [chemical binding]; other site 936156009306 Q-loop/lid; other site 936156009307 ABC transporter signature motif; other site 936156009308 Walker B; other site 936156009309 D-loop; other site 936156009310 H-loop/switch region; other site 936156009311 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 936156009312 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936156009313 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 936156009314 Walker A/P-loop; other site 936156009315 ATP binding site [chemical binding]; other site 936156009316 Q-loop/lid; other site 936156009317 ABC transporter signature motif; other site 936156009318 Walker B; other site 936156009319 D-loop; other site 936156009320 H-loop/switch region; other site 936156009321 Predicted membrane protein [Function unknown]; Region: COG2259 936156009322 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 936156009323 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 936156009324 putative metal binding site [ion binding]; other site 936156009325 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 936156009326 active site 936156009327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 936156009328 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 936156009329 Histidine kinase; Region: HisKA_3; pfam07730 936156009330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156009331 ATP binding site [chemical binding]; other site 936156009332 Mg2+ binding site [ion binding]; other site 936156009333 G-X-G motif; other site 936156009334 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936156009335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156009336 active site 936156009337 phosphorylation site [posttranslational modification] 936156009338 intermolecular recognition site; other site 936156009339 dimerization interface [polypeptide binding]; other site 936156009340 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936156009341 DNA binding residues [nucleotide binding] 936156009342 dimerization interface [polypeptide binding]; other site 936156009343 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 936156009344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936156009345 Walker A/P-loop; other site 936156009346 ATP binding site [chemical binding]; other site 936156009347 Q-loop/lid; other site 936156009348 ABC transporter signature motif; other site 936156009349 Walker B; other site 936156009350 D-loop; other site 936156009351 H-loop/switch region; other site 936156009352 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 936156009353 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 936156009354 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 936156009355 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 936156009356 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 936156009357 Predicted transcriptional regulators [Transcription]; Region: COG1695 936156009358 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 936156009359 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 936156009360 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 936156009361 Lipase (class 2); Region: Lipase_2; pfam01674 936156009362 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 936156009363 Acyltransferase family; Region: Acyl_transf_3; pfam01757 936156009364 metal-dependent hydrolase; Provisional; Region: PRK13291 936156009365 DinB superfamily; Region: DinB_2; pfam12867 936156009366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156009367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156009368 putative substrate translocation pore; other site 936156009369 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156009370 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936156009371 putative Zn2+ binding site [ion binding]; other site 936156009372 putative DNA binding site [nucleotide binding]; other site 936156009373 Predicted integral membrane protein [Function unknown]; Region: COG0392 936156009374 Uncharacterized conserved protein [Function unknown]; Region: COG2898 936156009375 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 936156009376 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 936156009377 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 936156009378 siderophore binding site; other site 936156009379 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 936156009380 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156009381 ABC-ATPase subunit interface; other site 936156009382 dimer interface [polypeptide binding]; other site 936156009383 putative PBP binding regions; other site 936156009384 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 936156009385 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936156009386 ABC-ATPase subunit interface; other site 936156009387 dimer interface [polypeptide binding]; other site 936156009388 putative PBP binding regions; other site 936156009389 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 936156009390 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 936156009391 putative FMN binding site [chemical binding]; other site 936156009392 YfhD-like protein; Region: YfhD; pfam14151 936156009393 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 936156009394 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 936156009395 putative NAD(P) binding site [chemical binding]; other site 936156009396 putative active site [active] 936156009397 recombination regulator RecX; Provisional; Region: recX; PRK14135 936156009398 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 936156009399 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936156009400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156009401 putative substrate translocation pore; other site 936156009402 Small acid-soluble spore protein K family; Region: SspK; pfam08176 936156009403 WVELL protein; Region: WVELL; pfam14043 936156009404 Bacterial SH3 domain; Region: SH3_3; pfam08239 936156009405 Bacterial SH3 domain; Region: SH3_3; cl17532 936156009406 Predicted integral membrane protein [Function unknown]; Region: COG5658 936156009407 SdpI/YhfL protein family; Region: SdpI; pfam13630 936156009408 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 936156009409 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 936156009410 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 936156009411 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 936156009412 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 936156009413 Ligand binding site; other site 936156009414 Putative Catalytic site; other site 936156009415 DXD motif; other site 936156009416 Predicted membrane protein [Function unknown]; Region: COG4485 936156009417 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 936156009418 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 936156009419 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 936156009420 minor groove reading motif; other site 936156009421 helix-hairpin-helix signature motif; other site 936156009422 substrate binding pocket [chemical binding]; other site 936156009423 active site 936156009424 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 936156009425 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 936156009426 DNA binding and oxoG recognition site [nucleotide binding] 936156009427 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 936156009428 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 936156009429 putative NAD(P) binding site [chemical binding]; other site 936156009430 active site 936156009431 YgaB-like protein; Region: YgaB; pfam14182 936156009432 hypothetical protein; Provisional; Region: PRK13662 936156009433 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 936156009434 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936156009435 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 936156009436 Walker A/P-loop; other site 936156009437 ATP binding site [chemical binding]; other site 936156009438 Q-loop/lid; other site 936156009439 ABC transporter signature motif; other site 936156009440 Walker B; other site 936156009441 D-loop; other site 936156009442 H-loop/switch region; other site 936156009443 Predicted membrane protein [Function unknown]; Region: COG4129 936156009444 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 936156009445 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 936156009446 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936156009447 inhibitor-cofactor binding pocket; inhibition site 936156009448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156009449 catalytic residue [active] 936156009450 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 936156009451 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 936156009452 catalytic triad [active] 936156009453 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 936156009454 metal binding site 2 [ion binding]; metal-binding site 936156009455 putative DNA binding helix; other site 936156009456 metal binding site 1 [ion binding]; metal-binding site 936156009457 dimer interface [polypeptide binding]; other site 936156009458 structural Zn2+ binding site [ion binding]; other site 936156009459 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 936156009460 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 936156009461 SpoOM protein; Region: Spo0M; pfam07070 936156009462 Coat F domain; Region: Coat_F; pfam07875 936156009463 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 936156009464 active site pocket [active] 936156009465 oxyanion hole [active] 936156009466 catalytic triad [active] 936156009467 active site nucleophile [active] 936156009468 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 936156009469 ThiC-associated domain; Region: ThiC-associated; pfam13667 936156009470 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 936156009471 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 936156009472 FAD binding domain; Region: FAD_binding_4; pfam01565 936156009473 Berberine and berberine like; Region: BBE; pfam08031 936156009474 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 936156009475 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 936156009476 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 936156009477 tetramer interface [polypeptide binding]; other site 936156009478 heme binding pocket [chemical binding]; other site 936156009479 NADPH binding site [chemical binding]; other site 936156009480 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 936156009481 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 936156009482 Walker A/P-loop; other site 936156009483 ATP binding site [chemical binding]; other site 936156009484 Q-loop/lid; other site 936156009485 ABC transporter signature motif; other site 936156009486 Walker B; other site 936156009487 D-loop; other site 936156009488 H-loop/switch region; other site 936156009489 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 936156009490 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936156009491 substrate binding pocket [chemical binding]; other site 936156009492 membrane-bound complex binding site; other site 936156009493 hinge residues; other site 936156009494 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 936156009495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156009496 dimer interface [polypeptide binding]; other site 936156009497 conserved gate region; other site 936156009498 putative PBP binding loops; other site 936156009499 ABC-ATPase subunit interface; other site 936156009500 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 936156009501 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 936156009502 active site 936156009503 dimer interface [polypeptide binding]; other site 936156009504 non-prolyl cis peptide bond; other site 936156009505 insertion regions; other site 936156009506 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 936156009507 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936156009508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156009509 non-specific DNA binding site [nucleotide binding]; other site 936156009510 salt bridge; other site 936156009511 sequence-specific DNA binding site [nucleotide binding]; other site 936156009512 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 936156009513 epoxyqueuosine reductase; Region: TIGR00276 936156009514 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 936156009515 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 936156009516 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 936156009517 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 936156009518 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 936156009519 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 936156009520 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 936156009521 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 936156009522 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 936156009523 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156009524 MarR family; Region: MarR; pfam01047 936156009525 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 936156009526 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 936156009527 carboxyltransferase (CT) interaction site; other site 936156009528 biotinylation site [posttranslational modification]; other site 936156009529 HlyD family secretion protein; Region: HlyD_3; pfam13437 936156009530 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 936156009531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156009532 putative substrate translocation pore; other site 936156009533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156009534 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 936156009535 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 936156009536 Predicted transcriptional regulators [Transcription]; Region: COG1725 936156009537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156009538 DNA-binding site [nucleotide binding]; DNA binding site 936156009539 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 936156009540 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 936156009541 Walker A/P-loop; other site 936156009542 ATP binding site [chemical binding]; other site 936156009543 Q-loop/lid; other site 936156009544 ABC transporter signature motif; other site 936156009545 Walker B; other site 936156009546 D-loop; other site 936156009547 H-loop/switch region; other site 936156009548 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 936156009549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936156009550 Walker A/P-loop; other site 936156009551 ATP binding site [chemical binding]; other site 936156009552 Q-loop/lid; other site 936156009553 ABC transporter signature motif; other site 936156009554 Walker B; other site 936156009555 D-loop; other site 936156009556 H-loop/switch region; other site 936156009557 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 936156009558 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 936156009559 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 936156009560 DNA-binding site [nucleotide binding]; DNA binding site 936156009561 RNA-binding motif; other site 936156009562 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 936156009563 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 936156009564 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 936156009565 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 936156009566 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936156009567 metal binding site [ion binding]; metal-binding site 936156009568 active site 936156009569 I-site; other site 936156009570 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 936156009571 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 936156009572 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 936156009573 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 936156009574 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 936156009575 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 936156009576 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 936156009577 generic binding surface II; other site 936156009578 generic binding surface I; other site 936156009579 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 936156009580 generic binding surface II; other site 936156009581 generic binding surface I; other site 936156009582 Staphylococcal nuclease homologues; Region: SNc; smart00318 936156009583 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 936156009584 Catalytic site; other site 936156009585 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 936156009586 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 936156009587 putative active site [active] 936156009588 putative metal binding site [ion binding]; other site 936156009589 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 936156009590 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 936156009591 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 936156009592 active site 936156009593 catalytic site [active] 936156009594 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 936156009595 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936156009596 RNA binding surface [nucleotide binding]; other site 936156009597 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 936156009598 active site 936156009599 FOG: CBS domain [General function prediction only]; Region: COG0517 936156009600 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 936156009601 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 936156009602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156009603 motif II; other site 936156009604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156009605 Coenzyme A binding pocket [chemical binding]; other site 936156009606 Predicted amidohydrolase [General function prediction only]; Region: COG0388 936156009607 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 936156009608 putative active site [active] 936156009609 catalytic triad [active] 936156009610 putative dimer interface [polypeptide binding]; other site 936156009611 aminotransferase; Validated; Region: PRK07678 936156009612 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936156009613 inhibitor-cofactor binding pocket; inhibition site 936156009614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156009615 catalytic residue [active] 936156009616 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 936156009617 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 936156009618 amphipathic channel; other site 936156009619 Asn-Pro-Ala signature motifs; other site 936156009620 glycerol kinase; Provisional; Region: glpK; PRK00047 936156009621 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 936156009622 N- and C-terminal domain interface [polypeptide binding]; other site 936156009623 active site 936156009624 MgATP binding site [chemical binding]; other site 936156009625 catalytic site [active] 936156009626 metal binding site [ion binding]; metal-binding site 936156009627 glycerol binding site [chemical binding]; other site 936156009628 homotetramer interface [polypeptide binding]; other site 936156009629 homodimer interface [polypeptide binding]; other site 936156009630 FBP binding site [chemical binding]; other site 936156009631 protein IIAGlc interface [polypeptide binding]; other site 936156009632 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 936156009633 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 936156009634 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 936156009635 active site 936156009636 substrate binding site [chemical binding]; other site 936156009637 metal binding site [ion binding]; metal-binding site 936156009638 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 936156009639 GAF domain; Region: GAF; pfam01590 936156009640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 936156009641 Histidine kinase; Region: HisKA_3; pfam07730 936156009642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156009643 ATP binding site [chemical binding]; other site 936156009644 Mg2+ binding site [ion binding]; other site 936156009645 G-X-G motif; other site 936156009646 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936156009647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156009648 active site 936156009649 phosphorylation site [posttranslational modification] 936156009650 intermolecular recognition site; other site 936156009651 dimerization interface [polypeptide binding]; other site 936156009652 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936156009653 DNA binding residues [nucleotide binding] 936156009654 dimerization interface [polypeptide binding]; other site 936156009655 Predicted flavoprotein [General function prediction only]; Region: COG0431 936156009656 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 936156009657 YhdB-like protein; Region: YhdB; pfam14148 936156009658 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 936156009659 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156009660 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156009661 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156009662 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156009663 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156009664 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 936156009665 NlpC/P60 family; Region: NLPC_P60; pfam00877 936156009666 Transcriptional regulator; Region: Rrf2; cl17282 936156009667 Rrf2 family protein; Region: rrf2_super; TIGR00738 936156009668 Conserved TM helix; Region: TM_helix; pfam05552 936156009669 Conserved TM helix; Region: TM_helix; pfam05552 936156009670 Conserved TM helix; Region: TM_helix; pfam05552 936156009671 Conserved TM helix; Region: TM_helix; pfam05552 936156009672 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 936156009673 SpoVR like protein; Region: SpoVR; pfam04293 936156009674 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 936156009675 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 936156009676 dimer interface [polypeptide binding]; other site 936156009677 active site 936156009678 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156009679 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156009680 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156009681 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 936156009682 NlpC/P60 family; Region: NLPC_P60; pfam00877 936156009683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156009684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156009685 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936156009686 dimerization interface [polypeptide binding]; other site 936156009687 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 936156009688 dimer interface [polypeptide binding]; other site 936156009689 Citrate synthase; Region: Citrate_synt; pfam00285 936156009690 active site 936156009691 citrylCoA binding site [chemical binding]; other site 936156009692 oxalacetate/citrate binding site [chemical binding]; other site 936156009693 coenzyme A binding site [chemical binding]; other site 936156009694 catalytic triad [active] 936156009695 short chain dehydrogenase; Provisional; Region: PRK06701 936156009696 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 936156009697 NAD binding site [chemical binding]; other site 936156009698 metal binding site [ion binding]; metal-binding site 936156009699 active site 936156009700 amino acid transporter; Region: 2A0306; TIGR00909 936156009701 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 936156009702 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 936156009703 Na2 binding site [ion binding]; other site 936156009704 putative substrate binding site 1 [chemical binding]; other site 936156009705 Na binding site 1 [ion binding]; other site 936156009706 putative substrate binding site 2 [chemical binding]; other site 936156009707 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 936156009708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156009709 DNA-binding site [nucleotide binding]; DNA binding site 936156009710 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156009711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156009712 homodimer interface [polypeptide binding]; other site 936156009713 catalytic residue [active] 936156009714 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 936156009715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156009716 Coenzyme A binding pocket [chemical binding]; other site 936156009717 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 936156009718 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 936156009719 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 936156009720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156009721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156009722 DNA binding residues [nucleotide binding] 936156009723 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936156009724 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936156009725 active site 936156009726 catalytic tetrad [active] 936156009727 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 936156009728 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 936156009729 putative acyl-acceptor binding pocket; other site 936156009730 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 936156009731 Domain of unknown function DUF21; Region: DUF21; pfam01595 936156009732 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 936156009733 Transporter associated domain; Region: CorC_HlyC; smart01091 936156009734 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 936156009735 aspartate aminotransferase; Provisional; Region: PRK06836 936156009736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156009737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156009738 homodimer interface [polypeptide binding]; other site 936156009739 catalytic residue [active] 936156009740 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 936156009741 Domain of unknown function DUF21; Region: DUF21; pfam01595 936156009742 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 936156009743 Transporter associated domain; Region: CorC_HlyC; smart01091 936156009744 camphor resistance protein CrcB; Provisional; Region: PRK14213 936156009745 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 936156009746 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 936156009747 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 936156009748 active site 936156009749 catalytic site [active] 936156009750 metal binding site [ion binding]; metal-binding site 936156009751 dimer interface [polypeptide binding]; other site 936156009752 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 936156009753 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936156009754 NAD-dependent deacetylase; Provisional; Region: PRK00481 936156009755 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 936156009756 NAD+ binding site [chemical binding]; other site 936156009757 substrate binding site [chemical binding]; other site 936156009758 Zn binding site [ion binding]; other site 936156009759 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 936156009760 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 936156009761 NodB motif; other site 936156009762 active site 936156009763 catalytic site [active] 936156009764 Zn binding site [ion binding]; other site 936156009765 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 936156009766 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 936156009767 homodimer interface [polypeptide binding]; other site 936156009768 substrate-cofactor binding pocket; other site 936156009769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156009770 catalytic residue [active] 936156009771 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 936156009772 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 936156009773 Ligand Binding Site [chemical binding]; other site 936156009774 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936156009775 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 936156009776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936156009777 Walker A/P-loop; other site 936156009778 ATP binding site [chemical binding]; other site 936156009779 Q-loop/lid; other site 936156009780 ABC transporter signature motif; other site 936156009781 Walker B; other site 936156009782 D-loop; other site 936156009783 H-loop/switch region; other site 936156009784 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 936156009785 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936156009786 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 936156009787 Walker A/P-loop; other site 936156009788 ATP binding site [chemical binding]; other site 936156009789 Q-loop/lid; other site 936156009790 ABC transporter signature motif; other site 936156009791 Walker B; other site 936156009792 D-loop; other site 936156009793 H-loop/switch region; other site 936156009794 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 936156009795 NADH(P)-binding; Region: NAD_binding_10; pfam13460 936156009796 NAD binding site [chemical binding]; other site 936156009797 substrate binding site [chemical binding]; other site 936156009798 putative active site [active] 936156009799 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 936156009800 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 936156009801 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 936156009802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 936156009803 hypothetical protein; Provisional; Region: PRK13676 936156009804 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 936156009805 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 936156009806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156009807 active site 936156009808 motif I; other site 936156009809 motif II; other site 936156009810 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 936156009811 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 936156009812 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936156009813 FeS/SAM binding site; other site 936156009814 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 936156009815 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 936156009816 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 936156009817 TrkA-C domain; Region: TrkA_C; pfam02080 936156009818 enoyl-CoA hydratase; Provisional; Region: PRK07659 936156009819 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 936156009820 substrate binding site [chemical binding]; other site 936156009821 oxyanion hole (OAH) forming residues; other site 936156009822 trimer interface [polypeptide binding]; other site 936156009823 YhzD-like protein; Region: YhzD; pfam14120 936156009824 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 936156009825 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 936156009826 Walker A/P-loop; other site 936156009827 ATP binding site [chemical binding]; other site 936156009828 Q-loop/lid; other site 936156009829 ABC transporter signature motif; other site 936156009830 Walker B; other site 936156009831 D-loop; other site 936156009832 H-loop/switch region; other site 936156009833 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 936156009834 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 936156009835 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 936156009836 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 936156009837 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 936156009838 active site 936156009839 metal binding site [ion binding]; metal-binding site 936156009840 DNA binding site [nucleotide binding] 936156009841 Uncharacterized conserved protein [Function unknown]; Region: COG4717 936156009842 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 936156009843 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 936156009844 generic binding surface II; other site 936156009845 generic binding surface I; other site 936156009846 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936156009847 Zn2+ binding site [ion binding]; other site 936156009848 Mg2+ binding site [ion binding]; other site 936156009849 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 936156009850 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 936156009851 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 936156009852 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 936156009853 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 936156009854 transcriptional regulator Hpr; Provisional; Region: PRK13777 936156009855 MarR family; Region: MarR; pfam01047 936156009856 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 936156009857 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 936156009858 homodimer interface [polypeptide binding]; other site 936156009859 substrate-cofactor binding pocket; other site 936156009860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156009861 catalytic residue [active] 936156009862 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 936156009863 HIT family signature motif; other site 936156009864 catalytic residue [active] 936156009865 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 936156009866 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 936156009867 Walker A/P-loop; other site 936156009868 ATP binding site [chemical binding]; other site 936156009869 Q-loop/lid; other site 936156009870 ABC transporter signature motif; other site 936156009871 Walker B; other site 936156009872 D-loop; other site 936156009873 H-loop/switch region; other site 936156009874 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 936156009875 EcsC protein family; Region: EcsC; pfam12787 936156009876 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 936156009877 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 936156009878 metal binding site [ion binding]; metal-binding site 936156009879 dimer interface [polypeptide binding]; other site 936156009880 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 936156009881 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 936156009882 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 936156009883 Transglycosylase; Region: Transgly; pfam00912 936156009884 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936156009885 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 936156009886 substrate binding site [chemical binding]; other site 936156009887 active site 936156009888 ferrochelatase; Provisional; Region: PRK12435 936156009889 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 936156009890 C-terminal domain interface [polypeptide binding]; other site 936156009891 active site 936156009892 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 936156009893 active site 936156009894 N-terminal domain interface [polypeptide binding]; other site 936156009895 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 936156009896 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 936156009897 SEA domain; Region: SEA; cl02507 936156009898 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936156009899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156009900 Predicted membrane protein [Function unknown]; Region: COG1511 936156009901 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 936156009902 Pex19 protein family; Region: Pex19; pfam04614 936156009903 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 936156009904 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 936156009905 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 936156009906 dimer interface [polypeptide binding]; other site 936156009907 active site 936156009908 CoA binding pocket [chemical binding]; other site 936156009909 Predicted membrane protein [Function unknown]; Region: COG4377 936156009910 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 936156009911 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 936156009912 putative oligomer interface [polypeptide binding]; other site 936156009913 putative active site [active] 936156009914 metal binding site [ion binding]; metal-binding site 936156009915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4405 936156009916 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 936156009917 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 936156009918 YhfH-like protein; Region: YhfH; pfam14149 936156009919 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 936156009920 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 936156009921 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 936156009922 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 936156009923 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 936156009924 NADH(P)-binding; Region: NAD_binding_10; pfam13460 936156009925 NAD(P) binding site [chemical binding]; other site 936156009926 putative active site [active] 936156009927 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 936156009928 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 936156009929 acyl-activating enzyme (AAE) consensus motif; other site 936156009930 putative AMP binding site [chemical binding]; other site 936156009931 putative active site [active] 936156009932 putative CoA binding site [chemical binding]; other site 936156009933 Peptidase family M48; Region: Peptidase_M48; pfam01435 936156009934 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 936156009935 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 936156009936 active site 936156009937 catalytic residues [active] 936156009938 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 936156009939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156009940 Coenzyme A binding pocket [chemical binding]; other site 936156009941 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 936156009942 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 936156009943 putative NADP binding site [chemical binding]; other site 936156009944 putative dimer interface [polypeptide binding]; other site 936156009945 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 936156009946 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 936156009947 siderophore binding site; other site 936156009948 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 936156009949 catalytic core [active] 936156009950 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 936156009951 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 936156009952 dimer interface [polypeptide binding]; other site 936156009953 active site 936156009954 acyl-CoA synthetase; Validated; Region: PRK07638 936156009955 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 936156009956 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 936156009957 acyl-activating enzyme (AAE) consensus motif; other site 936156009958 acyl-activating enzyme (AAE) consensus motif; other site 936156009959 AMP binding site [chemical binding]; other site 936156009960 active site 936156009961 CoA binding site [chemical binding]; other site 936156009962 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 936156009963 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 936156009964 heme-binding site [chemical binding]; other site 936156009965 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936156009966 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936156009967 dimer interface [polypeptide binding]; other site 936156009968 putative CheW interface [polypeptide binding]; other site 936156009969 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 936156009970 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 936156009971 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 936156009972 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 936156009973 [2Fe-2S] cluster binding site [ion binding]; other site 936156009974 short chain dehydrogenase; Provisional; Region: PRK06701 936156009975 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 936156009976 NAD binding site [chemical binding]; other site 936156009977 metal binding site [ion binding]; metal-binding site 936156009978 active site 936156009979 IDEAL domain; Region: IDEAL; pfam08858 936156009980 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 936156009981 oxidoreductase; Provisional; Region: PRK07985 936156009982 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 936156009983 NAD binding site [chemical binding]; other site 936156009984 metal binding site [ion binding]; metal-binding site 936156009985 active site 936156009986 Excalibur calcium-binding domain; Region: Excalibur; cl05460 936156009987 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 936156009988 Na binding site [ion binding]; other site 936156009989 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 936156009990 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 936156009991 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 936156009992 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 936156009993 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 936156009994 Catalytic site [active] 936156009995 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 936156009996 hypothetical protein; Provisional; Region: PRK08244 936156009997 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 936156009998 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156009999 MarR family; Region: MarR; pfam01047 936156010000 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 936156010001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156010002 putative substrate translocation pore; other site 936156010003 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 936156010004 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936156010005 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 936156010006 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 936156010007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156010008 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 936156010009 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 936156010010 inhibitor-cofactor binding pocket; inhibition site 936156010011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156010012 catalytic residue [active] 936156010013 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936156010014 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936156010015 DNA binding site [nucleotide binding] 936156010016 domain linker motif; other site 936156010017 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 936156010018 putative dimerization interface [polypeptide binding]; other site 936156010019 putative ligand binding site [chemical binding]; other site 936156010020 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 936156010021 Putative ammonia monooxygenase; Region: AmoA; pfam05145 936156010022 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 936156010023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156010024 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156010025 putative substrate translocation pore; other site 936156010026 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 936156010027 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 936156010028 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 936156010029 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 936156010030 dimerization interface [polypeptide binding]; other site 936156010031 Uncharacterized conserved protein [Function unknown]; Region: COG1633 936156010032 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 936156010033 dinuclear metal binding motif [ion binding]; other site 936156010034 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 936156010035 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 936156010036 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 936156010037 Part of AAA domain; Region: AAA_19; pfam13245 936156010038 Family description; Region: UvrD_C_2; pfam13538 936156010039 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 936156010040 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 936156010041 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 936156010042 active site 936156010043 metal binding site [ion binding]; metal-binding site 936156010044 DNA binding site [nucleotide binding] 936156010045 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 936156010046 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 936156010047 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 936156010048 Walker A/P-loop; other site 936156010049 ATP binding site [chemical binding]; other site 936156010050 Q-loop/lid; other site 936156010051 ABC transporter signature motif; other site 936156010052 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 936156010053 ABC transporter signature motif; other site 936156010054 Walker B; other site 936156010055 D-loop; other site 936156010056 H-loop/switch region; other site 936156010057 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 936156010058 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 936156010059 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 936156010060 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 936156010061 Spore germination protein GerPC; Region: GerPC; pfam10737 936156010062 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 936156010063 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 936156010064 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 936156010065 CotH protein; Region: CotH; pfam08757 936156010066 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 936156010067 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 936156010068 hypothetical protein; Provisional; Region: PRK13673 936156010069 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 936156010070 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 936156010071 active site 936156010072 catalytic triad [active] 936156010073 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 936156010074 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 936156010075 active site 936156010076 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 936156010077 dimer interface [polypeptide binding]; other site 936156010078 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 936156010079 Ligand Binding Site [chemical binding]; other site 936156010080 Molecular Tunnel; other site 936156010081 DinB family; Region: DinB; cl17821 936156010082 DinB superfamily; Region: DinB_2; pfam12867 936156010083 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 936156010084 substrate binding pocket [chemical binding]; other site 936156010085 aspartate-rich region 2; other site 936156010086 substrate-Mg2+ binding site; other site 936156010087 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 936156010088 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 936156010089 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 936156010090 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156010091 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936156010092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936156010093 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936156010094 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936156010095 DNA binding site [nucleotide binding] 936156010096 domain linker motif; other site 936156010097 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 936156010098 dimerization interface [polypeptide binding]; other site 936156010099 ligand binding site [chemical binding]; other site 936156010100 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 936156010101 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936156010102 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 936156010103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 936156010104 Lysine efflux permease [General function prediction only]; Region: COG1279 936156010105 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 936156010106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156010107 DNA-binding site [nucleotide binding]; DNA binding site 936156010108 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156010109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156010110 homodimer interface [polypeptide binding]; other site 936156010111 catalytic residue [active] 936156010112 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 936156010113 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 936156010114 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 936156010115 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 936156010116 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 936156010117 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 936156010118 ligand-binding site [chemical binding]; other site 936156010119 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 936156010120 ATP-sulfurylase; Region: ATPS; cd00517 936156010121 active site 936156010122 HXXH motif; other site 936156010123 flexible loop; other site 936156010124 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 936156010125 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 936156010126 Active Sites [active] 936156010127 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 936156010128 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 936156010129 (2R)-phospho-3-sulfolactate synthase (PSL synthase, CoM biosynthesis) [Coenzyme transport and metabolism]; Region: COG1809 936156010130 Uncharacterized conserved protein [Function unknown]; Region: COG1284 936156010131 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156010132 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 936156010133 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 936156010134 active site pocket [active] 936156010135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156010136 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156010137 putative substrate translocation pore; other site 936156010138 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 936156010139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156010140 Coenzyme A binding pocket [chemical binding]; other site 936156010141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 936156010142 Coenzyme A binding pocket [chemical binding]; other site 936156010143 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 936156010144 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 936156010145 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 936156010146 FAD binding site [chemical binding]; other site 936156010147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 936156010148 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 936156010149 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 936156010150 S1 domain; Region: S1_2; pfam13509 936156010151 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 936156010152 RNA binding site [nucleotide binding]; other site 936156010153 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 936156010154 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 936156010155 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 936156010156 Predicted transcriptional regulators [Transcription]; Region: COG1695 936156010157 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 936156010158 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 936156010159 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 936156010160 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 936156010161 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 936156010162 active site 936156010163 Zn binding site [ion binding]; other site 936156010164 EDD domain protein, DegV family; Region: DegV; TIGR00762 936156010165 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 936156010166 Uncharacterized conserved protein [Function unknown]; Region: COG1284 936156010167 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156010168 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 936156010169 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 936156010170 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 936156010171 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 936156010172 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 936156010173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156010174 motif II; other site 936156010175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156010176 esterase; Provisional; Region: PRK10566 936156010177 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 936156010178 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 936156010179 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 936156010180 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 936156010181 FAD binding domain; Region: FAD_binding_4; pfam01565 936156010182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156010183 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156010184 putative substrate translocation pore; other site 936156010185 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 936156010186 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 936156010187 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 936156010188 heterotetramer interface [polypeptide binding]; other site 936156010189 active site pocket [active] 936156010190 cleavage site 936156010191 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 936156010192 nucleotide binding site [chemical binding]; other site 936156010193 N-acetyl-L-glutamate binding site [chemical binding]; other site 936156010194 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 936156010195 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936156010196 inhibitor-cofactor binding pocket; inhibition site 936156010197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156010198 catalytic residue [active] 936156010199 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 936156010200 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 936156010201 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 936156010202 catalytic site [active] 936156010203 subunit interface [polypeptide binding]; other site 936156010204 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 936156010205 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936156010206 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 936156010207 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 936156010208 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936156010209 ATP-grasp domain; Region: ATP-grasp_4; cl17255 936156010210 ornithine carbamoyltransferase; Provisional; Region: PRK00779 936156010211 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 936156010212 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 936156010213 YjzC-like protein; Region: YjzC; pfam14168 936156010214 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 936156010215 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 936156010216 UDP-apiose/xylose synthase; Region: PLN02427 936156010217 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 936156010218 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 936156010219 putative ligand binding site [chemical binding]; other site 936156010220 ComZ; Region: ComZ; pfam10815 936156010221 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 936156010222 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 936156010223 dimer interface [polypeptide binding]; other site 936156010224 active site 936156010225 CoA binding pocket [chemical binding]; other site 936156010226 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 936156010227 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 936156010228 dimer interface [polypeptide binding]; other site 936156010229 active site 936156010230 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 936156010231 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 936156010232 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936156010233 Walker A/P-loop; other site 936156010234 ATP binding site [chemical binding]; other site 936156010235 Q-loop/lid; other site 936156010236 ABC transporter signature motif; other site 936156010237 Walker B; other site 936156010238 D-loop; other site 936156010239 H-loop/switch region; other site 936156010240 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 936156010241 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 936156010242 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936156010243 Walker A/P-loop; other site 936156010244 ATP binding site [chemical binding]; other site 936156010245 Q-loop/lid; other site 936156010246 ABC transporter signature motif; other site 936156010247 Walker B; other site 936156010248 D-loop; other site 936156010249 H-loop/switch region; other site 936156010250 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 936156010251 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 936156010252 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 936156010253 peptide binding site [polypeptide binding]; other site 936156010254 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 936156010255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156010256 dimer interface [polypeptide binding]; other site 936156010257 conserved gate region; other site 936156010258 putative PBP binding loops; other site 936156010259 ABC-ATPase subunit interface; other site 936156010260 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 936156010261 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 936156010262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156010263 dimer interface [polypeptide binding]; other site 936156010264 conserved gate region; other site 936156010265 putative PBP binding loops; other site 936156010266 ABC-ATPase subunit interface; other site 936156010267 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 936156010268 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 936156010269 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 936156010270 active site 936156010271 HIGH motif; other site 936156010272 dimer interface [polypeptide binding]; other site 936156010273 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 936156010274 KMSKS motif; other site 936156010275 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 936156010276 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 936156010277 peptide binding site [polypeptide binding]; other site 936156010278 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 936156010279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156010280 dimer interface [polypeptide binding]; other site 936156010281 conserved gate region; other site 936156010282 putative PBP binding loops; other site 936156010283 ABC-ATPase subunit interface; other site 936156010284 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 936156010285 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 936156010286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156010287 dimer interface [polypeptide binding]; other site 936156010288 conserved gate region; other site 936156010289 putative PBP binding loops; other site 936156010290 ABC-ATPase subunit interface; other site 936156010291 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 936156010292 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936156010293 Walker A/P-loop; other site 936156010294 ATP binding site [chemical binding]; other site 936156010295 Q-loop/lid; other site 936156010296 ABC transporter signature motif; other site 936156010297 Walker B; other site 936156010298 D-loop; other site 936156010299 H-loop/switch region; other site 936156010300 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 936156010301 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 936156010302 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936156010303 Walker A/P-loop; other site 936156010304 ATP binding site [chemical binding]; other site 936156010305 Q-loop/lid; other site 936156010306 ABC transporter signature motif; other site 936156010307 Walker B; other site 936156010308 D-loop; other site 936156010309 H-loop/switch region; other site 936156010310 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 936156010311 H+ Antiporter protein; Region: 2A0121; TIGR00900 936156010312 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 936156010313 ArsC family; Region: ArsC; pfam03960 936156010314 putative catalytic residues [active] 936156010315 thiol/disulfide switch; other site 936156010316 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 936156010317 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 936156010318 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 936156010319 oligoendopeptidase F; Region: pepF; TIGR00181 936156010320 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 936156010321 active site 936156010322 Zn binding site [ion binding]; other site 936156010323 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 936156010324 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 936156010325 catalytic residues [active] 936156010326 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 936156010327 apolar tunnel; other site 936156010328 heme binding site [chemical binding]; other site 936156010329 dimerization interface [polypeptide binding]; other site 936156010330 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 936156010331 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 936156010332 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936156010333 catalytic residue [active] 936156010334 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 936156010335 putative active site [active] 936156010336 putative metal binding residues [ion binding]; other site 936156010337 signature motif; other site 936156010338 putative triphosphate binding site [ion binding]; other site 936156010339 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 936156010340 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 936156010341 synthetase active site [active] 936156010342 NTP binding site [chemical binding]; other site 936156010343 metal binding site [ion binding]; metal-binding site 936156010344 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 936156010345 ATP-NAD kinase; Region: NAD_kinase; pfam01513 936156010346 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 936156010347 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 936156010348 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 936156010349 active site 936156010350 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 936156010351 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 936156010352 active site 936156010353 metal binding site [ion binding]; metal-binding site 936156010354 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 936156010355 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 936156010356 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 936156010357 TrkA-N domain; Region: TrkA_N; pfam02254 936156010358 TrkA-C domain; Region: TrkA_C; pfam02080 936156010359 thiaminase II; Region: salvage_TenA; TIGR04306 936156010360 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 936156010361 thiamine phosphate binding site [chemical binding]; other site 936156010362 active site 936156010363 pyrophosphate binding site [ion binding]; other site 936156010364 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 936156010365 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 936156010366 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 936156010367 thiS-thiF/thiG interaction site; other site 936156010368 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 936156010369 ThiS interaction site; other site 936156010370 putative active site [active] 936156010371 tetramer interface [polypeptide binding]; other site 936156010372 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 936156010373 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 936156010374 ATP binding site [chemical binding]; other site 936156010375 substrate interface [chemical binding]; other site 936156010376 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 936156010377 dimer interface [polypeptide binding]; other site 936156010378 substrate binding site [chemical binding]; other site 936156010379 ATP binding site [chemical binding]; other site 936156010380 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 936156010381 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 936156010382 NAD binding site [chemical binding]; other site 936156010383 homotetramer interface [polypeptide binding]; other site 936156010384 homodimer interface [polypeptide binding]; other site 936156010385 substrate binding site [chemical binding]; other site 936156010386 active site 936156010387 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 936156010388 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 936156010389 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 936156010390 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 936156010391 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 936156010392 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 936156010393 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 936156010394 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 936156010395 Part of AAA domain; Region: AAA_19; pfam13245 936156010396 Family description; Region: UvrD_C_2; pfam13538 936156010397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156010398 Coenzyme A binding pocket [chemical binding]; other site 936156010399 hypothetical protein; Provisional; Region: PRK13679 936156010400 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 936156010401 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 936156010402 Putative esterase; Region: Esterase; pfam00756 936156010403 cystathionine gamma-synthase; Reviewed; Region: PRK08247 936156010404 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 936156010405 homodimer interface [polypeptide binding]; other site 936156010406 substrate-cofactor binding pocket; other site 936156010407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156010408 catalytic residue [active] 936156010409 cystathionine beta-lyase; Provisional; Region: PRK08064 936156010410 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 936156010411 homodimer interface [polypeptide binding]; other site 936156010412 substrate-cofactor binding pocket; other site 936156010413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156010414 catalytic residue [active] 936156010415 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 936156010416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 936156010417 Predicted integral membrane protein [Function unknown]; Region: COG5505 936156010418 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 936156010419 LXG domain of WXG superfamily; Region: LXG; pfam04740 936156010420 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 936156010421 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 936156010422 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 936156010423 YolD-like protein; Region: YolD; pfam08863 936156010424 Uncharacterized conserved protein [Function unknown]; Region: COG1359 936156010425 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 936156010426 classical (c) SDRs; Region: SDR_c; cd05233 936156010427 NAD(P) binding site [chemical binding]; other site 936156010428 active site 936156010429 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 936156010430 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 936156010431 HTH domain; Region: HTH_11; pfam08279 936156010432 PRD domain; Region: PRD; pfam00874 936156010433 PRD domain; Region: PRD; pfam00874 936156010434 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 936156010435 active site 936156010436 P-loop; other site 936156010437 phosphorylation site [posttranslational modification] 936156010438 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936156010439 active site 936156010440 phosphorylation site [posttranslational modification] 936156010441 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 936156010442 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 936156010443 active site 936156010444 P-loop; other site 936156010445 phosphorylation site [posttranslational modification] 936156010446 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 936156010447 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936156010448 active site 936156010449 phosphorylation site [posttranslational modification] 936156010450 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 936156010451 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 936156010452 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 936156010453 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 936156010454 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 936156010455 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 936156010456 putative deacylase active site [active] 936156010457 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 936156010458 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 936156010459 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 936156010460 UbiA prenyltransferase family; Region: UbiA; pfam01040 936156010461 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 936156010462 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 936156010463 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 936156010464 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 936156010465 NodB motif; other site 936156010466 active site 936156010467 catalytic site [active] 936156010468 Zn binding site [ion binding]; other site 936156010469 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 936156010470 Putative motility protein; Region: YjfB_motility; pfam14070 936156010471 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 936156010472 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 936156010473 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 936156010474 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 936156010475 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 936156010476 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 936156010477 4Fe-4S binding domain; Region: Fer4_6; pfam12837 936156010478 4Fe-4S binding domain; Region: Fer4; pfam00037 936156010479 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 936156010480 [4Fe-4S] binding site [ion binding]; other site 936156010481 molybdopterin cofactor binding site; other site 936156010482 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 936156010483 molybdopterin cofactor binding site; other site 936156010484 Uncharacterized conserved protein [Function unknown]; Region: COG2427 936156010485 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 936156010486 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 936156010487 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 936156010488 nudix motif; other site 936156010489 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 936156010490 Cytochrome P450; Region: p450; cl12078 936156010491 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 936156010492 glycosyltransferase, MGT family; Region: MGT; TIGR01426 936156010493 active site 936156010494 TDP-binding site; other site 936156010495 acceptor substrate-binding pocket; other site 936156010496 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 936156010497 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 936156010498 active site 936156010499 TIGR00245 family protein; Region: TIGR00245 936156010500 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 936156010501 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 936156010502 Walker A/P-loop; other site 936156010503 ATP binding site [chemical binding]; other site 936156010504 Q-loop/lid; other site 936156010505 ABC transporter signature motif; other site 936156010506 Walker B; other site 936156010507 D-loop; other site 936156010508 H-loop/switch region; other site 936156010509 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 936156010510 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 936156010511 Uncharacterized conserved protein [Function unknown]; Region: COG2427 936156010512 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 936156010513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936156010514 Glucuronate isomerase; Region: UxaC; pfam02614 936156010515 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 936156010516 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 936156010517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156010518 putative substrate translocation pore; other site 936156010519 Malate/L-lactate dehydrogenase; Region: Ldh_2; pfam02615 936156010520 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 936156010521 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 936156010522 putative NAD(P) binding site [chemical binding]; other site 936156010523 catalytic Zn binding site [ion binding]; other site 936156010524 structural Zn binding site [ion binding]; other site 936156010525 mannonate dehydratase; Provisional; Region: PRK03906 936156010526 mannonate dehydratase; Region: uxuA; TIGR00695 936156010527 D-mannonate oxidoreductase; Provisional; Region: PRK08277 936156010528 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 936156010529 putative NAD(P) binding site [chemical binding]; other site 936156010530 active site 936156010531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156010532 D-galactonate transporter; Region: 2A0114; TIGR00893 936156010533 putative substrate translocation pore; other site 936156010534 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936156010535 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936156010536 DNA binding site [nucleotide binding] 936156010537 domain linker motif; other site 936156010538 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 936156010539 dimerization interface [polypeptide binding]; other site 936156010540 ligand binding site [chemical binding]; other site 936156010541 altronate oxidoreductase; Provisional; Region: PRK03643 936156010542 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 936156010543 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 936156010544 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 936156010545 galactarate dehydratase; Region: galactar-dH20; TIGR03248 936156010546 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 936156010547 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 936156010548 DinB family; Region: DinB; pfam05163 936156010549 DinB superfamily; Region: DinB_2; pfam12867 936156010550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156010551 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 936156010552 Walker A motif; other site 936156010553 ATP binding site [chemical binding]; other site 936156010554 Walker B motif; other site 936156010555 arginine finger; other site 936156010556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156010557 binding surface 936156010558 TPR motif; other site 936156010559 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936156010560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936156010561 binding surface 936156010562 TPR motif; other site 936156010563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 936156010564 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 936156010565 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 936156010566 amidase catalytic site [active] 936156010567 Zn binding residues [ion binding]; other site 936156010568 substrate binding site [chemical binding]; other site 936156010569 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 936156010570 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156010571 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 936156010572 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 936156010573 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 936156010574 pentamer interface [polypeptide binding]; other site 936156010575 dodecaamer interface [polypeptide binding]; other site 936156010576 Phage-related replication protein [General function prediction only]; Region: COG4195 936156010577 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 936156010578 dimanganese center [ion binding]; other site 936156010579 Domain of unknown function (DUF955); Region: DUF955; pfam06114 936156010580 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936156010581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156010582 non-specific DNA binding site [nucleotide binding]; other site 936156010583 salt bridge; other site 936156010584 sequence-specific DNA binding site [nucleotide binding]; other site 936156010585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 936156010586 putative Zn2+ binding site [ion binding]; other site 936156010587 putative DNA binding site [nucleotide binding]; other site 936156010588 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 936156010589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156010590 Walker A motif; other site 936156010591 ATP binding site [chemical binding]; other site 936156010592 Walker B motif; other site 936156010593 positive control sigma-like factor; Validated; Region: PRK06930 936156010594 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156010595 DNA binding residues [nucleotide binding] 936156010596 Phage terminase small subunit; Region: Phage_terminase; pfam10668 936156010597 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 936156010598 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 936156010599 Terminase-like family; Region: Terminase_6; pfam03237 936156010600 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 936156010601 Phage capsid family; Region: Phage_capsid; pfam05065 936156010602 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 936156010603 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 936156010604 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 936156010605 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 936156010606 Phage XkdN-like protein; Region: XkdN; pfam08890 936156010607 potential frameshift: common BLAST hit: gi|308173246|ref|YP_003919951.1| partial Phage-like element PBSX protein xkdO 936156010608 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 936156010609 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156010610 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 936156010611 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 936156010612 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 936156010613 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 936156010614 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 936156010615 XkdW protein; Region: XkdW; pfam09636 936156010616 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 936156010617 Haemolysin XhlA; Region: XhlA; pfam10779 936156010618 holin, SPP1 family; Region: holin_SPP1; TIGR01592 936156010619 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 936156010620 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 936156010621 amidase catalytic site [active] 936156010622 Zn binding residues [ion binding]; other site 936156010623 substrate binding site [chemical binding]; other site 936156010624 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 936156010625 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156010626 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 936156010627 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 936156010628 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 936156010629 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 936156010630 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 936156010631 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 936156010632 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 936156010633 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 936156010634 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156010635 Zn binding site [ion binding]; other site 936156010636 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 936156010637 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936156010638 Zn binding site [ion binding]; other site 936156010639 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 936156010640 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 936156010641 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 936156010642 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 936156010643 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 936156010644 Ligand binding site; other site 936156010645 Putative Catalytic site; other site 936156010646 DXD motif; other site 936156010647 Trypsin; Region: Trypsin; pfam00089 936156010648 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 936156010649 protein binding site [polypeptide binding]; other site 936156010650 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 936156010651 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 936156010652 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 936156010653 SxDxEG motif; other site 936156010654 active site 936156010655 metal binding site [ion binding]; metal-binding site 936156010656 homopentamer interface [polypeptide binding]; other site 936156010657 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 936156010658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156010659 dimer interface [polypeptide binding]; other site 936156010660 conserved gate region; other site 936156010661 putative PBP binding loops; other site 936156010662 ABC-ATPase subunit interface; other site 936156010663 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 936156010664 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 936156010665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936156010666 dimer interface [polypeptide binding]; other site 936156010667 conserved gate region; other site 936156010668 putative PBP binding loops; other site 936156010669 ABC-ATPase subunit interface; other site 936156010670 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 936156010671 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936156010672 Walker A/P-loop; other site 936156010673 ATP binding site [chemical binding]; other site 936156010674 Q-loop/lid; other site 936156010675 ABC transporter signature motif; other site 936156010676 Walker B; other site 936156010677 D-loop; other site 936156010678 H-loop/switch region; other site 936156010679 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 936156010680 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 936156010681 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 936156010682 peptide binding site [polypeptide binding]; other site 936156010683 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 936156010684 dimer interface [polypeptide binding]; other site 936156010685 catalytic triad [active] 936156010686 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 936156010687 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 936156010688 active site 936156010689 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 936156010690 NlpC/P60 family; Region: NLPC_P60; pfam00877 936156010691 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 936156010692 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936156010693 Walker A/P-loop; other site 936156010694 ATP binding site [chemical binding]; other site 936156010695 Q-loop/lid; other site 936156010696 ABC transporter signature motif; other site 936156010697 Walker B; other site 936156010698 D-loop; other site 936156010699 H-loop/switch region; other site 936156010700 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 936156010701 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 936156010702 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 936156010703 Amidinotransferase; Region: Amidinotransf; pfam02274 936156010704 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 936156010705 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 936156010706 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 936156010707 heme-binding site [chemical binding]; other site 936156010708 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 936156010709 FAD binding pocket [chemical binding]; other site 936156010710 FAD binding motif [chemical binding]; other site 936156010711 phosphate binding motif [ion binding]; other site 936156010712 beta-alpha-beta structure motif; other site 936156010713 NAD binding pocket [chemical binding]; other site 936156010714 Heme binding pocket [chemical binding]; other site 936156010715 Predicted membrane protein [Function unknown]; Region: COG2323 936156010716 DinB superfamily; Region: DinB_2; pfam12867 936156010717 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 936156010718 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 936156010719 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 936156010720 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 936156010721 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 936156010722 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 936156010723 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 936156010724 putative active site [active] 936156010725 putative substrate binding site [chemical binding]; other site 936156010726 putative cosubstrate binding site; other site 936156010727 catalytic site [active] 936156010728 glutamate 5-kinase; Region: proB; TIGR01027 936156010729 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 936156010730 nucleotide binding site [chemical binding]; other site 936156010731 homotetrameric interface [polypeptide binding]; other site 936156010732 putative phosphate binding site [ion binding]; other site 936156010733 putative allosteric binding site; other site 936156010734 PUA domain; Region: PUA; pfam01472 936156010735 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 936156010736 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 936156010737 putative catalytic cysteine [active] 936156010738 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 936156010739 Transcriptional regulators [Transcription]; Region: MarR; COG1846 936156010740 MarR family; Region: MarR; pfam01047 936156010741 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 936156010742 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 936156010743 nucleoside/Zn binding site; other site 936156010744 dimer interface [polypeptide binding]; other site 936156010745 catalytic motif [active] 936156010746 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 936156010747 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 936156010748 THF binding site; other site 936156010749 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 936156010750 substrate binding site [chemical binding]; other site 936156010751 THF binding site; other site 936156010752 zinc-binding site [ion binding]; other site 936156010753 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 936156010754 active site 936156010755 catalytic residues [active] 936156010756 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 936156010757 Cobalt transport protein; Region: CbiQ; pfam02361 936156010758 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 936156010759 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 936156010760 Walker A/P-loop; other site 936156010761 ATP binding site [chemical binding]; other site 936156010762 Q-loop/lid; other site 936156010763 ABC transporter signature motif; other site 936156010764 Walker B; other site 936156010765 D-loop; other site 936156010766 H-loop/switch region; other site 936156010767 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 936156010768 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 936156010769 Walker A/P-loop; other site 936156010770 ATP binding site [chemical binding]; other site 936156010771 Q-loop/lid; other site 936156010772 ABC transporter signature motif; other site 936156010773 Walker B; other site 936156010774 D-loop; other site 936156010775 H-loop/switch region; other site 936156010776 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 936156010777 YKOF-related Family; Region: Ykof; pfam07615 936156010778 YKOF-related Family; Region: Ykof; pfam07615 936156010779 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936156010780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156010781 active site 936156010782 phosphorylation site [posttranslational modification] 936156010783 intermolecular recognition site; other site 936156010784 dimerization interface [polypeptide binding]; other site 936156010785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936156010786 DNA binding site [nucleotide binding] 936156010787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936156010788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936156010789 dimerization interface [polypeptide binding]; other site 936156010790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156010791 dimer interface [polypeptide binding]; other site 936156010792 phosphorylation site [posttranslational modification] 936156010793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156010794 ATP binding site [chemical binding]; other site 936156010795 Mg2+ binding site [ion binding]; other site 936156010796 G-X-G motif; other site 936156010797 Predicted membrane protein [Function unknown]; Region: COG3212 936156010798 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 936156010799 Predicted membrane protein [Function unknown]; Region: COG3212 936156010800 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 936156010801 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 936156010802 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 936156010803 MgtE intracellular N domain; Region: MgtE_N; smart00924 936156010804 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 936156010805 Divalent cation transporter; Region: MgtE; pfam01769 936156010806 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 936156010807 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 936156010808 DNA binding residues [nucleotide binding] 936156010809 putative dimer interface [polypeptide binding]; other site 936156010810 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156010811 MarR family; Region: MarR; pfam01047 936156010812 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 936156010813 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 936156010814 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 936156010815 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 936156010816 putative active site [active] 936156010817 putative metal binding site [ion binding]; other site 936156010818 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 936156010819 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 936156010820 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 936156010821 Ligand binding site; other site 936156010822 Putative Catalytic site; other site 936156010823 DXD motif; other site 936156010824 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 936156010825 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 936156010826 active site 936156010827 DNA binding site [nucleotide binding] 936156010828 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 936156010829 nucleotide binding site [chemical binding]; other site 936156010830 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 936156010831 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 936156010832 putative DNA binding site [nucleotide binding]; other site 936156010833 putative homodimer interface [polypeptide binding]; other site 936156010834 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 936156010835 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 936156010836 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 936156010837 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 936156010838 PAS domain S-box; Region: sensory_box; TIGR00229 936156010839 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936156010840 metal binding site [ion binding]; metal-binding site 936156010841 active site 936156010842 I-site; other site 936156010843 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936156010844 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 936156010845 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 936156010846 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 936156010847 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 936156010848 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156010849 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 936156010850 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 936156010851 heat shock protein HtpX; Provisional; Region: PRK05457 936156010852 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 936156010853 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 936156010854 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 936156010855 Acyltransferase family; Region: Acyl_transf_3; pfam01757 936156010856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156010857 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 936156010858 putative active site [active] 936156010859 heme pocket [chemical binding]; other site 936156010860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 936156010861 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 936156010862 putative active site [active] 936156010863 heme pocket [chemical binding]; other site 936156010864 PAS domain; Region: PAS; smart00091 936156010865 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 936156010866 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156010867 putative active site [active] 936156010868 heme pocket [chemical binding]; other site 936156010869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156010870 dimer interface [polypeptide binding]; other site 936156010871 phosphorylation site [posttranslational modification] 936156010872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156010873 ATP binding site [chemical binding]; other site 936156010874 Mg2+ binding site [ion binding]; other site 936156010875 G-X-G motif; other site 936156010876 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 936156010877 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 936156010878 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 936156010879 DNA binding site [nucleotide binding] 936156010880 active site 936156010881 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 936156010882 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 936156010883 Predicted kinase [General function prediction only]; Region: COG4857 936156010884 Phosphotransferase enzyme family; Region: APH; pfam01636 936156010885 Predicted amidohydrolase [General function prediction only]; Region: COG0388 936156010886 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 936156010887 putative active site [active] 936156010888 catalytic triad [active] 936156010889 putative dimer interface [polypeptide binding]; other site 936156010890 transaminase; Reviewed; Region: PRK08068 936156010891 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156010892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156010893 homodimer interface [polypeptide binding]; other site 936156010894 catalytic residue [active] 936156010895 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 936156010896 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 936156010897 dimer interface [polypeptide binding]; other site 936156010898 active site 936156010899 catalytic residue [active] 936156010900 metal binding site [ion binding]; metal-binding site 936156010901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156010902 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 936156010903 motif II; other site 936156010904 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 936156010905 intersubunit interface [polypeptide binding]; other site 936156010906 active site 936156010907 Zn2+ binding site [ion binding]; other site 936156010908 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 936156010909 Cupin domain; Region: Cupin_2; pfam07883 936156010910 Uncharacterized conserved protein [Function unknown]; Region: COG3339 936156010911 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 936156010912 Cache domain; Region: Cache_1; pfam02743 936156010913 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 936156010914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156010915 dimer interface [polypeptide binding]; other site 936156010916 phosphorylation site [posttranslational modification] 936156010917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156010918 ATP binding site [chemical binding]; other site 936156010919 Mg2+ binding site [ion binding]; other site 936156010920 G-X-G motif; other site 936156010921 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936156010922 MarR family; Region: MarR; pfam01047 936156010923 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 936156010924 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 936156010925 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 936156010926 ligand binding site [chemical binding]; other site 936156010927 flagellar motor protein MotA; Validated; Region: PRK08124 936156010928 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 936156010929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156010930 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 936156010931 Walker A motif; other site 936156010932 ATP binding site [chemical binding]; other site 936156010933 Walker B motif; other site 936156010934 arginine finger; other site 936156010935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156010936 Walker A motif; other site 936156010937 ATP binding site [chemical binding]; other site 936156010938 Walker B motif; other site 936156010939 arginine finger; other site 936156010940 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 936156010941 Uncharacterized membrane protein [Function unknown]; Region: COG3949 936156010942 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 936156010943 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 936156010944 Ligand Binding Site [chemical binding]; other site 936156010945 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 936156010946 active site 936156010947 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 936156010948 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936156010949 FeS/SAM binding site; other site 936156010950 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 936156010951 Predicted transcriptional regulators [Transcription]; Region: COG1733 936156010952 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 936156010953 short chain dehydrogenase; Provisional; Region: PRK06500 936156010954 classical (c) SDRs; Region: SDR_c; cd05233 936156010955 NAD(P) binding site [chemical binding]; other site 936156010956 active site 936156010957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 936156010958 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 936156010959 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 936156010960 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 936156010961 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156010962 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 936156010963 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156010964 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 936156010965 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 936156010966 active site 936156010967 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 936156010968 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 936156010969 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 936156010970 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 936156010971 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 936156010972 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 936156010973 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 936156010974 catalytic residues [active] 936156010975 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 936156010976 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 936156010977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156010978 motif II; other site 936156010979 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 936156010980 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 936156010981 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 936156010982 active site 936156010983 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936156010984 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936156010985 DNA binding site [nucleotide binding] 936156010986 domain linker motif; other site 936156010987 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 936156010988 putative dimerization interface [polypeptide binding]; other site 936156010989 putative ligand binding site [chemical binding]; other site 936156010990 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 936156010991 CAT RNA binding domain; Region: CAT_RBD; pfam03123 936156010992 PRD domain; Region: PRD; pfam00874 936156010993 PRD domain; Region: PRD; pfam00874 936156010994 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 936156010995 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 936156010996 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 936156010997 active site turn [active] 936156010998 phosphorylation site [posttranslational modification] 936156010999 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 936156011000 HPr interaction site; other site 936156011001 glycerol kinase (GK) interaction site [polypeptide binding]; other site 936156011002 active site 936156011003 phosphorylation site [posttranslational modification] 936156011004 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 936156011005 dimerization domain swap beta strand [polypeptide binding]; other site 936156011006 regulatory protein interface [polypeptide binding]; other site 936156011007 active site 936156011008 regulatory phosphorylation site [posttranslational modification]; other site 936156011009 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 936156011010 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 936156011011 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 936156011012 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 936156011013 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 936156011014 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 936156011015 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936156011016 FeS/SAM binding site; other site 936156011017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156011018 Coenzyme A binding pocket [chemical binding]; other site 936156011019 Cache domain; Region: Cache_1; pfam02743 936156011020 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936156011021 dimerization interface [polypeptide binding]; other site 936156011022 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936156011023 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936156011024 dimer interface [polypeptide binding]; other site 936156011025 putative CheW interface [polypeptide binding]; other site 936156011026 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 936156011027 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 936156011028 potential frameshift: common BLAST hit: gi|154685808|ref|YP_001420969.1| YkwD 936156011029 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 936156011030 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 936156011031 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 936156011032 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936156011033 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156011034 putative active site [active] 936156011035 heme pocket [chemical binding]; other site 936156011036 PAS fold; Region: PAS; pfam00989 936156011037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156011038 putative active site [active] 936156011039 heme pocket [chemical binding]; other site 936156011040 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 936156011041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156011042 putative active site [active] 936156011043 heme pocket [chemical binding]; other site 936156011044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156011045 dimer interface [polypeptide binding]; other site 936156011046 phosphorylation site [posttranslational modification] 936156011047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156011048 ATP binding site [chemical binding]; other site 936156011049 Mg2+ binding site [ion binding]; other site 936156011050 G-X-G motif; other site 936156011051 aminotransferase A; Validated; Region: PRK07683 936156011052 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936156011053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156011054 homodimer interface [polypeptide binding]; other site 936156011055 catalytic residue [active] 936156011056 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 936156011057 putative CheA interaction surface; other site 936156011058 Response regulator receiver domain; Region: Response_reg; pfam00072 936156011059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156011060 active site 936156011061 phosphorylation site [posttranslational modification] 936156011062 intermolecular recognition site; other site 936156011063 dimerization interface [polypeptide binding]; other site 936156011064 YkyB-like protein; Region: YkyB; pfam14177 936156011065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156011066 H+ Antiporter protein; Region: 2A0121; TIGR00900 936156011067 putative substrate translocation pore; other site 936156011068 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936156011069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 936156011070 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 936156011071 phosphodiesterase YaeI; Provisional; Region: PRK11340 936156011072 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 936156011073 putative active site [active] 936156011074 putative metal binding site [ion binding]; other site 936156011075 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 936156011076 short chain dehydrogenase; Provisional; Region: PRK07677 936156011077 NAD(P) binding site [chemical binding]; other site 936156011078 substrate binding site [chemical binding]; other site 936156011079 homotetramer interface [polypeptide binding]; other site 936156011080 active site 936156011081 homodimer interface [polypeptide binding]; other site 936156011082 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936156011083 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 936156011084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 936156011085 Protein of unknown function (DUF458); Region: DUF458; pfam04308 936156011086 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 936156011087 FOG: CBS domain [General function prediction only]; Region: COG0517 936156011088 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 936156011089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936156011090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936156011091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936156011092 dimerization interface [polypeptide binding]; other site 936156011093 flavodoxin; Provisional; Region: PRK06703 936156011094 BNR repeat-like domain; Region: BNR_2; pfam13088 936156011095 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 936156011096 flavodoxin, short chain; Region: flav_short; TIGR01753 936156011097 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 936156011098 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 936156011099 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 936156011100 active site 936156011101 trimer interface [polypeptide binding]; other site 936156011102 substrate binding site [chemical binding]; other site 936156011103 CoA binding site [chemical binding]; other site 936156011104 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 936156011105 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 936156011106 metal binding site [ion binding]; metal-binding site 936156011107 putative dimer interface [polypeptide binding]; other site 936156011108 hypothetical protein; Provisional; Region: PRK03094 936156011109 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 936156011110 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936156011111 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 936156011112 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 936156011113 dimer interface [polypeptide binding]; other site 936156011114 decamer (pentamer of dimers) interface [polypeptide binding]; other site 936156011115 catalytic triad [active] 936156011116 peroxidatic and resolving cysteines [active] 936156011117 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 936156011118 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 936156011119 catalytic residues [active] 936156011120 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 936156011121 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 936156011122 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 936156011123 GTP binding site; other site 936156011124 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 936156011125 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 936156011126 ATP binding site [chemical binding]; other site 936156011127 substrate interface [chemical binding]; other site 936156011128 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 936156011129 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 936156011130 dimer interface [polypeptide binding]; other site 936156011131 putative functional site; other site 936156011132 putative MPT binding site; other site 936156011133 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 936156011134 Walker A motif; other site 936156011135 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 936156011136 MoaE homodimer interface [polypeptide binding]; other site 936156011137 MoaD interaction [polypeptide binding]; other site 936156011138 active site residues [active] 936156011139 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 936156011140 MoaE interaction surface [polypeptide binding]; other site 936156011141 MoeB interaction surface [polypeptide binding]; other site 936156011142 thiocarboxylated glycine; other site 936156011143 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 936156011144 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936156011145 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 936156011146 Walker A/P-loop; other site 936156011147 ATP binding site [chemical binding]; other site 936156011148 Q-loop/lid; other site 936156011149 ABC transporter signature motif; other site 936156011150 Walker B; other site 936156011151 D-loop; other site 936156011152 H-loop/switch region; other site 936156011153 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 936156011154 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936156011155 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 936156011156 Walker A/P-loop; other site 936156011157 ATP binding site [chemical binding]; other site 936156011158 Q-loop/lid; other site 936156011159 ABC transporter signature motif; other site 936156011160 Walker B; other site 936156011161 D-loop; other site 936156011162 H-loop/switch region; other site 936156011163 Yip1 domain; Region: Yip1; pfam04893 936156011164 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 936156011165 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936156011166 HlyD family secretion protein; Region: HlyD_3; pfam13437 936156011167 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 936156011168 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 936156011169 Walker A/P-loop; other site 936156011170 ATP binding site [chemical binding]; other site 936156011171 Q-loop/lid; other site 936156011172 ABC transporter signature motif; other site 936156011173 Walker B; other site 936156011174 D-loop; other site 936156011175 H-loop/switch region; other site 936156011176 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 936156011177 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 936156011178 FtsX-like permease family; Region: FtsX; pfam02687 936156011179 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936156011180 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 936156011181 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936156011182 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 936156011183 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 936156011184 putative substrate binding site [chemical binding]; other site 936156011185 putative ATP binding site [chemical binding]; other site 936156011186 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 936156011187 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936156011188 active site 936156011189 phosphorylation site [posttranslational modification] 936156011190 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 936156011191 active site 936156011192 P-loop; other site 936156011193 phosphorylation site [posttranslational modification] 936156011194 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 936156011195 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 936156011196 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 936156011197 Catalytic site [active] 936156011198 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 936156011199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936156011200 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936156011201 ABC transporter; Region: ABC_tran_2; pfam12848 936156011202 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936156011203 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 936156011204 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 936156011205 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 936156011206 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 936156011207 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 936156011208 rod-share determining protein MreBH; Provisional; Region: PRK13929 936156011209 MreB and similar proteins; Region: MreB_like; cd10225 936156011210 nucleotide binding site [chemical binding]; other site 936156011211 Mg binding site [ion binding]; other site 936156011212 putative protofilament interaction site [polypeptide binding]; other site 936156011213 RodZ interaction site [polypeptide binding]; other site 936156011214 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 936156011215 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 936156011216 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 936156011217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936156011218 putative active site [active] 936156011219 heme pocket [chemical binding]; other site 936156011220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936156011221 dimer interface [polypeptide binding]; other site 936156011222 phosphorylation site [posttranslational modification] 936156011223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156011224 ATP binding site [chemical binding]; other site 936156011225 Mg2+ binding site [ion binding]; other site 936156011226 G-X-G motif; other site 936156011227 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 936156011228 putative active site pocket [active] 936156011229 dimerization interface [polypeptide binding]; other site 936156011230 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 936156011231 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 936156011232 putative active site pocket [active] 936156011233 dimerization interface [polypeptide binding]; other site 936156011234 putative catalytic residue [active] 936156011235 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 936156011236 TrkA-N domain; Region: TrkA_N; pfam02254 936156011237 TrkA-C domain; Region: TrkA_C; pfam02080 936156011238 adenine deaminase; Region: ade; TIGR01178 936156011239 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 936156011240 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 936156011241 active site 936156011242 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 936156011243 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 936156011244 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 936156011245 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 936156011246 hypothetical protein; Provisional; Region: PRK13667 936156011247 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 936156011248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156011249 active site 936156011250 motif I; other site 936156011251 motif II; other site 936156011252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156011253 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 936156011254 active site 936156011255 catalytic residues [active] 936156011256 metal binding site [ion binding]; metal-binding site 936156011257 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 936156011258 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 936156011259 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 936156011260 TPP-binding site [chemical binding]; other site 936156011261 tetramer interface [polypeptide binding]; other site 936156011262 heterodimer interface [polypeptide binding]; other site 936156011263 phosphorylation loop region [posttranslational modification] 936156011264 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 936156011265 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 936156011266 alpha subunit interface [polypeptide binding]; other site 936156011267 TPP binding site [chemical binding]; other site 936156011268 heterodimer interface [polypeptide binding]; other site 936156011269 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 936156011270 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 936156011271 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 936156011272 E3 interaction surface; other site 936156011273 lipoyl attachment site [posttranslational modification]; other site 936156011274 e3 binding domain; Region: E3_binding; pfam02817 936156011275 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 936156011276 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 936156011277 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 936156011278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936156011279 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 936156011280 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 936156011281 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 936156011282 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 936156011283 homodimer interface [polypeptide binding]; other site 936156011284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156011285 catalytic residue [active] 936156011286 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 936156011287 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 936156011288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 936156011289 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 936156011290 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 936156011291 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 936156011292 active site 936156011293 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 936156011294 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 936156011295 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 936156011296 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 936156011297 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 936156011298 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 936156011299 active site 936156011300 Zn binding site [ion binding]; other site 936156011301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156011302 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 936156011303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156011304 DNA binding residues [nucleotide binding] 936156011305 Putative zinc-finger; Region: zf-HC2; pfam13490 936156011306 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 936156011307 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 936156011308 G1 box; other site 936156011309 putative GEF interaction site [polypeptide binding]; other site 936156011310 GTP/Mg2+ binding site [chemical binding]; other site 936156011311 Switch I region; other site 936156011312 G2 box; other site 936156011313 G3 box; other site 936156011314 Switch II region; other site 936156011315 G4 box; other site 936156011316 G5 box; other site 936156011317 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 936156011318 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 936156011319 YlaH-like protein; Region: YlaH; pfam14036 936156011320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 936156011321 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 936156011322 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 936156011323 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 936156011324 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 936156011325 putative active site [active] 936156011326 PhoH-like protein; Region: PhoH; pfam02562 936156011327 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 936156011328 glutaminase A; Region: Gln_ase; TIGR03814 936156011329 hypothetical protein; Provisional; Region: PRK13666 936156011330 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 936156011331 pyruvate carboxylase; Reviewed; Region: PRK12999 936156011332 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936156011333 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 936156011334 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 936156011335 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 936156011336 active site 936156011337 catalytic residues [active] 936156011338 metal binding site [ion binding]; metal-binding site 936156011339 homodimer binding site [polypeptide binding]; other site 936156011340 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 936156011341 carboxyltransferase (CT) interaction site; other site 936156011342 biotinylation site [posttranslational modification]; other site 936156011343 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 936156011344 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 936156011345 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 936156011346 UbiA prenyltransferase family; Region: UbiA; pfam01040 936156011347 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 936156011348 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 936156011349 Cytochrome c; Region: Cytochrom_C; pfam00034 936156011350 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 936156011351 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 936156011352 D-pathway; other site 936156011353 Putative ubiquinol binding site [chemical binding]; other site 936156011354 Low-spin heme (heme b) binding site [chemical binding]; other site 936156011355 Putative water exit pathway; other site 936156011356 Binuclear center (heme o3/CuB) [ion binding]; other site 936156011357 K-pathway; other site 936156011358 Putative proton exit pathway; other site 936156011359 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 936156011360 Subunit I/III interface [polypeptide binding]; other site 936156011361 Subunit III/IV interface [polypeptide binding]; other site 936156011362 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 936156011363 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 936156011364 YugN-like family; Region: YugN; pfam08868 936156011365 FOG: CBS domain [General function prediction only]; Region: COG0517 936156011366 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 936156011367 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 936156011368 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 936156011369 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 936156011370 Putative coat protein; Region: YlbD_coat; pfam14071 936156011371 YlbE-like protein; Region: YlbE; pfam14003 936156011372 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 936156011373 hypothetical protein; Provisional; Region: PRK02886 936156011374 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 936156011375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156011376 S-adenosylmethionine binding site [chemical binding]; other site 936156011377 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 936156011378 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 936156011379 active site 936156011380 (T/H)XGH motif; other site 936156011381 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 936156011382 Nucleoside recognition; Region: Gate; pfam07670 936156011383 Nucleoside recognition; Region: Gate; pfam07670 936156011384 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 936156011385 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 936156011386 nucleophile elbow; other site 936156011387 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 936156011388 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 936156011389 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 936156011390 protein binding site [polypeptide binding]; other site 936156011391 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 936156011392 hypothetical protein; Provisional; Region: PRK13670 936156011393 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 936156011394 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 936156011395 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 936156011396 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 936156011397 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 936156011398 hypothetical protein; Provisional; Region: PRK13688 936156011399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936156011400 Coenzyme A binding pocket [chemical binding]; other site 936156011401 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 936156011402 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 936156011403 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 936156011404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 936156011405 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 936156011406 mraZ protein; Region: TIGR00242 936156011407 MraZ protein; Region: MraZ; pfam02381 936156011408 MraZ protein; Region: MraZ; pfam02381 936156011409 MraW methylase family; Region: Methyltransf_5; pfam01795 936156011410 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 936156011411 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 936156011412 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 936156011413 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 936156011414 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936156011415 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 936156011416 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 936156011417 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 936156011418 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 936156011419 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936156011420 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 936156011421 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 936156011422 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 936156011423 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936156011424 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936156011425 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 936156011426 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 936156011427 Mg++ binding site [ion binding]; other site 936156011428 putative catalytic motif [active] 936156011429 putative substrate binding site [chemical binding]; other site 936156011430 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 936156011431 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936156011432 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936156011433 stage V sporulation protein E; Region: spoVE; TIGR02615 936156011434 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 936156011435 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 936156011436 active site 936156011437 homodimer interface [polypeptide binding]; other site 936156011438 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 936156011439 FAD binding domain; Region: FAD_binding_4; pfam01565 936156011440 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 936156011441 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 936156011442 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 936156011443 Cell division protein FtsQ; Region: FtsQ; pfam03799 936156011444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 936156011445 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 936156011446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 936156011447 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 936156011448 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 936156011449 cell division protein FtsA; Region: ftsA; TIGR01174 936156011450 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936156011451 nucleotide binding site [chemical binding]; other site 936156011452 Cell division protein FtsA; Region: FtsA; pfam14450 936156011453 cell division protein FtsZ; Validated; Region: PRK09330 936156011454 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 936156011455 nucleotide binding site [chemical binding]; other site 936156011456 SulA interaction site; other site 936156011457 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 936156011458 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 936156011459 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 936156011460 active site 936156011461 catalytic triad [active] 936156011462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 936156011463 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 936156011464 Cna protein B-type domain; Region: Cna_B_2; pfam13715 936156011465 Cna protein B-type domain; Region: Cna_B_2; pfam13715 936156011466 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 936156011467 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 936156011468 sporulation sigma factor SigE; Reviewed; Region: PRK08301 936156011469 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156011470 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156011471 DNA binding residues [nucleotide binding] 936156011472 sporulation sigma factor SigG; Reviewed; Region: PRK08215 936156011473 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156011474 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 936156011475 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156011476 DNA binding residues [nucleotide binding] 936156011477 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 936156011478 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 936156011479 Walker A/P-loop; other site 936156011480 ATP binding site [chemical binding]; other site 936156011481 Q-loop/lid; other site 936156011482 ABC transporter signature motif; other site 936156011483 Walker B; other site 936156011484 D-loop; other site 936156011485 H-loop/switch region; other site 936156011486 acetylornithine deacetylase; Validated; Region: PRK08596 936156011487 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 936156011488 metal binding site [ion binding]; metal-binding site 936156011489 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 936156011490 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 936156011491 uncharacterized protein, YfiH family; Region: TIGR00726 936156011492 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 936156011493 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936156011494 catalytic residue [active] 936156011495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 936156011496 YGGT family; Region: YGGT; pfam02325 936156011497 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 936156011498 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936156011499 RNA binding surface [nucleotide binding]; other site 936156011500 DivIVA protein; Region: DivIVA; pfam05103 936156011501 DivIVA domain; Region: DivI1A_domain; TIGR03544 936156011502 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 936156011503 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 936156011504 HIGH motif; other site 936156011505 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 936156011506 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 936156011507 active site 936156011508 KMSKS motif; other site 936156011509 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 936156011510 tRNA binding surface [nucleotide binding]; other site 936156011511 anticodon binding site; other site 936156011512 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 936156011513 lipoprotein signal peptidase; Region: lspA; TIGR00077 936156011514 lipoprotein signal peptidase; Provisional; Region: PRK14787 936156011515 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 936156011516 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936156011517 RNA binding surface [nucleotide binding]; other site 936156011518 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 936156011519 active site 936156011520 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 936156011521 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936156011522 active site 936156011523 uracil-xanthine permease; Region: ncs2; TIGR00801 936156011524 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 936156011525 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 936156011526 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 936156011527 dihydroorotase; Validated; Region: pyrC; PRK09357 936156011528 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 936156011529 active site 936156011530 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 936156011531 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 936156011532 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 936156011533 catalytic site [active] 936156011534 subunit interface [polypeptide binding]; other site 936156011535 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 936156011536 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936156011537 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 936156011538 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 936156011539 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936156011540 ATP-grasp domain; Region: ATP-grasp_4; cl17255 936156011541 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 936156011542 IMP binding site; other site 936156011543 dimer interface [polypeptide binding]; other site 936156011544 interdomain contacts; other site 936156011545 partial ornithine binding site; other site 936156011546 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 936156011547 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 936156011548 FAD binding pocket [chemical binding]; other site 936156011549 FAD binding motif [chemical binding]; other site 936156011550 phosphate binding motif [ion binding]; other site 936156011551 beta-alpha-beta structure motif; other site 936156011552 NAD binding pocket [chemical binding]; other site 936156011553 Iron coordination center [ion binding]; other site 936156011554 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 936156011555 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 936156011556 heterodimer interface [polypeptide binding]; other site 936156011557 active site 936156011558 FMN binding site [chemical binding]; other site 936156011559 homodimer interface [polypeptide binding]; other site 936156011560 substrate binding site [chemical binding]; other site 936156011561 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 936156011562 active site 936156011563 dimer interface [polypeptide binding]; other site 936156011564 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936156011565 active site 936156011566 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 936156011567 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 936156011568 Active Sites [active] 936156011569 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 936156011570 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 936156011571 ATP-sulfurylase; Region: ATPS; cd00517 936156011572 active site 936156011573 HXXH motif; other site 936156011574 flexible loop; other site 936156011575 AAA domain; Region: AAA_33; pfam13671 936156011576 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 936156011577 ligand-binding site [chemical binding]; other site 936156011578 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 936156011579 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 936156011580 active site 936156011581 SAM binding site [chemical binding]; other site 936156011582 homodimer interface [polypeptide binding]; other site 936156011583 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 936156011584 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 936156011585 putative active site [active] 936156011586 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 936156011587 putative active site [active] 936156011588 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 936156011589 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 936156011590 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 936156011591 Domain of unknown function (DUF814); Region: DUF814; pfam05670 936156011592 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 936156011593 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 936156011594 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 936156011595 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 936156011596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936156011597 motif II; other site 936156011598 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 936156011599 TIGR00255 family protein; Region: TIGR00255 936156011600 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 936156011601 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 936156011602 hypothetical protein; Provisional; Region: PRK04323 936156011603 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 936156011604 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 936156011605 catalytic site [active] 936156011606 G-X2-G-X-G-K; other site 936156011607 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 936156011608 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 936156011609 Flavoprotein; Region: Flavoprotein; pfam02441 936156011610 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 936156011611 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 936156011612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936156011613 ATP binding site [chemical binding]; other site 936156011614 putative Mg++ binding site [ion binding]; other site 936156011615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156011616 nucleotide binding region [chemical binding]; other site 936156011617 ATP-binding site [chemical binding]; other site 936156011618 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 936156011619 active site 936156011620 catalytic residues [active] 936156011621 metal binding site [ion binding]; metal-binding site 936156011622 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 936156011623 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 936156011624 putative active site [active] 936156011625 substrate binding site [chemical binding]; other site 936156011626 putative cosubstrate binding site; other site 936156011627 catalytic site [active] 936156011628 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 936156011629 substrate binding site [chemical binding]; other site 936156011630 16S rRNA methyltransferase B; Provisional; Region: PRK14902 936156011631 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 936156011632 putative RNA binding site [nucleotide binding]; other site 936156011633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156011634 S-adenosylmethionine binding site [chemical binding]; other site 936156011635 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 936156011636 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936156011637 FeS/SAM binding site; other site 936156011638 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 936156011639 Protein phosphatase 2C; Region: PP2C; pfam00481 936156011640 active site 936156011641 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 936156011642 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 936156011643 active site 936156011644 ATP binding site [chemical binding]; other site 936156011645 substrate binding site [chemical binding]; other site 936156011646 activation loop (A-loop); other site 936156011647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 936156011648 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 936156011649 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 936156011650 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 936156011651 GTPase RsgA; Reviewed; Region: PRK00098 936156011652 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 936156011653 RNA binding site [nucleotide binding]; other site 936156011654 homodimer interface [polypeptide binding]; other site 936156011655 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 936156011656 GTPase/Zn-binding domain interface [polypeptide binding]; other site 936156011657 GTP/Mg2+ binding site [chemical binding]; other site 936156011658 G4 box; other site 936156011659 G5 box; other site 936156011660 G1 box; other site 936156011661 Switch I region; other site 936156011662 G2 box; other site 936156011663 G3 box; other site 936156011664 Switch II region; other site 936156011665 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 936156011666 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 936156011667 substrate binding site [chemical binding]; other site 936156011668 hexamer interface [polypeptide binding]; other site 936156011669 metal binding site [ion binding]; metal-binding site 936156011670 Thiamine pyrophosphokinase; Region: TPK; cd07995 936156011671 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 936156011672 active site 936156011673 dimerization interface [polypeptide binding]; other site 936156011674 thiamine binding site [chemical binding]; other site 936156011675 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 936156011676 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 936156011677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 936156011678 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 936156011679 DAK2 domain; Region: Dak2; pfam02734 936156011680 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 936156011681 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 936156011682 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 936156011683 putative L-serine binding site [chemical binding]; other site 936156011684 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Region: sda_alpha; TIGR00718 936156011685 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 936156011686 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 936156011687 Pathogenicity locus; Region: Cdd1; pfam11731 936156011688 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 936156011689 generic binding surface II; other site 936156011690 ssDNA binding site; other site 936156011691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936156011692 ATP binding site [chemical binding]; other site 936156011693 putative Mg++ binding site [ion binding]; other site 936156011694 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936156011695 nucleotide binding region [chemical binding]; other site 936156011696 ATP-binding site [chemical binding]; other site 936156011697 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 936156011698 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 936156011699 putative phosphate acyltransferase; Provisional; Region: PRK05331 936156011700 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 936156011701 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 936156011702 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 936156011703 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 936156011704 NAD(P) binding site [chemical binding]; other site 936156011705 homotetramer interface [polypeptide binding]; other site 936156011706 homodimer interface [polypeptide binding]; other site 936156011707 active site 936156011708 acyl carrier protein; Provisional; Region: acpP; PRK00982 936156011709 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 936156011710 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 936156011711 dimerization interface [polypeptide binding]; other site 936156011712 active site 936156011713 metal binding site [ion binding]; metal-binding site 936156011714 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 936156011715 dsRNA binding site [nucleotide binding]; other site 936156011716 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 936156011717 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 936156011718 Walker A/P-loop; other site 936156011719 ATP binding site [chemical binding]; other site 936156011720 Q-loop/lid; other site 936156011721 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 936156011722 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 936156011723 ABC transporter signature motif; other site 936156011724 Walker B; other site 936156011725 D-loop; other site 936156011726 H-loop/switch region; other site 936156011727 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 936156011728 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 936156011729 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 936156011730 GTP binding site [chemical binding]; other site 936156011731 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 936156011732 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 936156011733 putative DNA-binding protein; Validated; Region: PRK00118 936156011734 signal recognition particle protein; Provisional; Region: PRK10867 936156011735 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 936156011736 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 936156011737 P loop; other site 936156011738 GTP binding site [chemical binding]; other site 936156011739 Signal peptide binding domain; Region: SRP_SPB; pfam02978 936156011740 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 936156011741 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 936156011742 KH domain; Region: KH_4; pfam13083 936156011743 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 936156011744 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 936156011745 RimM N-terminal domain; Region: RimM; pfam01782 936156011746 PRC-barrel domain; Region: PRC; pfam05239 936156011747 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 936156011748 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 936156011749 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 936156011750 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 936156011751 GTP/Mg2+ binding site [chemical binding]; other site 936156011752 G4 box; other site 936156011753 G5 box; other site 936156011754 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 936156011755 G1 box; other site 936156011756 G1 box; other site 936156011757 GTP/Mg2+ binding site [chemical binding]; other site 936156011758 Switch I region; other site 936156011759 G2 box; other site 936156011760 G2 box; other site 936156011761 G3 box; other site 936156011762 G3 box; other site 936156011763 Switch II region; other site 936156011764 Switch II region; other site 936156011765 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 936156011766 RNA/DNA hybrid binding site [nucleotide binding]; other site 936156011767 active site 936156011768 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 936156011769 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 936156011770 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 936156011771 CoA-ligase; Region: Ligase_CoA; pfam00549 936156011772 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 936156011773 CoA binding domain; Region: CoA_binding; smart00881 936156011774 CoA-ligase; Region: Ligase_CoA; pfam00549 936156011775 DNA protecting protein DprA; Region: dprA; TIGR00732 936156011776 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 936156011777 DNA topoisomerase I; Validated; Region: PRK05582 936156011778 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 936156011779 active site 936156011780 interdomain interaction site; other site 936156011781 putative metal-binding site [ion binding]; other site 936156011782 nucleotide binding site [chemical binding]; other site 936156011783 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 936156011784 domain I; other site 936156011785 DNA binding groove [nucleotide binding] 936156011786 phosphate binding site [ion binding]; other site 936156011787 domain II; other site 936156011788 domain III; other site 936156011789 nucleotide binding site [chemical binding]; other site 936156011790 catalytic site [active] 936156011791 domain IV; other site 936156011792 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 936156011793 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 936156011794 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 936156011795 Glucose inhibited division protein A; Region: GIDA; pfam01134 936156011796 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 936156011797 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 936156011798 active site 936156011799 Int/Topo IB signature motif; other site 936156011800 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 936156011801 active site 936156011802 HslU subunit interaction site [polypeptide binding]; other site 936156011803 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 936156011804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156011805 Walker A motif; other site 936156011806 ATP binding site [chemical binding]; other site 936156011807 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 936156011808 Walker B motif; other site 936156011809 arginine finger; other site 936156011810 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 936156011811 transcriptional repressor CodY; Validated; Region: PRK04158 936156011812 CodY GAF-like domain; Region: CodY; pfam06018 936156011813 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 936156011814 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 936156011815 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 936156011816 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 936156011817 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 936156011818 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 936156011819 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 936156011820 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 936156011821 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 936156011822 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 936156011823 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 936156011824 flagellar motor switch protein FliG; Region: fliG; TIGR00207 936156011825 MgtE intracellular N domain; Region: MgtE_N; smart00924 936156011826 FliG C-terminal domain; Region: FliG_C; pfam01706 936156011827 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 936156011828 Flagellar assembly protein FliH; Region: FliH; pfam02108 936156011829 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 936156011830 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 936156011831 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 936156011832 Walker A motif/ATP binding site; other site 936156011833 Walker B motif; other site 936156011834 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 936156011835 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 936156011836 Uncharacterized conserved protein [Function unknown]; Region: COG3334 936156011837 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 936156011838 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 936156011839 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 936156011840 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 936156011841 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 936156011842 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 936156011843 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 936156011844 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 936156011845 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 936156011846 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 936156011847 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 936156011848 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 936156011849 flagellar motor switch protein; Validated; Region: PRK08119 936156011850 CheC-like family; Region: CheC; pfam04509 936156011851 CheC-like family; Region: CheC; pfam04509 936156011852 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 936156011853 Response regulator receiver domain; Region: Response_reg; pfam00072 936156011854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156011855 active site 936156011856 phosphorylation site [posttranslational modification] 936156011857 intermolecular recognition site; other site 936156011858 dimerization interface [polypeptide binding]; other site 936156011859 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 936156011860 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 936156011861 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 936156011862 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 936156011863 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 936156011864 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 936156011865 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 936156011866 FHIPEP family; Region: FHIPEP; pfam00771 936156011867 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 936156011868 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 936156011869 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 936156011870 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 936156011871 P-loop; other site 936156011872 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 936156011873 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 936156011874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936156011875 active site 936156011876 phosphorylation site [posttranslational modification] 936156011877 intermolecular recognition site; other site 936156011878 dimerization interface [polypeptide binding]; other site 936156011879 CheB methylesterase; Region: CheB_methylest; pfam01339 936156011880 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 936156011881 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 936156011882 putative binding surface; other site 936156011883 active site 936156011884 P2 response regulator binding domain; Region: P2; pfam07194 936156011885 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 936156011886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156011887 ATP binding site [chemical binding]; other site 936156011888 Mg2+ binding site [ion binding]; other site 936156011889 G-X-G motif; other site 936156011890 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 936156011891 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 936156011892 putative CheA interaction surface; other site 936156011893 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 936156011894 CheC-like family; Region: CheC; pfam04509 936156011895 CheC-like family; Region: CheC; pfam04509 936156011896 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 936156011897 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 936156011898 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936156011899 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 936156011900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936156011901 DNA binding residues [nucleotide binding] 936156011902 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 936156011903 rRNA interaction site [nucleotide binding]; other site 936156011904 S8 interaction site; other site 936156011905 putative laminin-1 binding site; other site 936156011906 elongation factor Ts; Provisional; Region: tsf; PRK09377 936156011907 UBA/TS-N domain; Region: UBA; pfam00627 936156011908 Elongation factor TS; Region: EF_TS; pfam00889 936156011909 Elongation factor TS; Region: EF_TS; pfam00889 936156011910 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 936156011911 putative nucleotide binding site [chemical binding]; other site 936156011912 uridine monophosphate binding site [chemical binding]; other site 936156011913 homohexameric interface [polypeptide binding]; other site 936156011914 ribosome recycling factor; Reviewed; Region: frr; PRK00083 936156011915 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 936156011916 hinge region; other site 936156011917 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 936156011918 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 936156011919 catalytic residue [active] 936156011920 putative FPP diphosphate binding site; other site 936156011921 putative FPP binding hydrophobic cleft; other site 936156011922 dimer interface [polypeptide binding]; other site 936156011923 putative IPP diphosphate binding site; other site 936156011924 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 936156011925 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 936156011926 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 936156011927 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 936156011928 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 936156011929 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 936156011930 RIP metalloprotease RseP; Region: TIGR00054 936156011931 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 936156011932 active site 936156011933 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 936156011934 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 936156011935 protein binding site [polypeptide binding]; other site 936156011936 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 936156011937 putative substrate binding region [chemical binding]; other site 936156011938 prolyl-tRNA synthetase; Provisional; Region: PRK09194 936156011939 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 936156011940 dimer interface [polypeptide binding]; other site 936156011941 motif 1; other site 936156011942 active site 936156011943 motif 2; other site 936156011944 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 936156011945 putative deacylase active site [active] 936156011946 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 936156011947 active site 936156011948 motif 3; other site 936156011949 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 936156011950 anticodon binding site; other site 936156011951 DNA polymerase III PolC; Validated; Region: polC; PRK00448 936156011952 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 936156011953 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 936156011954 generic binding surface II; other site 936156011955 generic binding surface I; other site 936156011956 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 936156011957 active site 936156011958 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 936156011959 active site 936156011960 catalytic site [active] 936156011961 substrate binding site [chemical binding]; other site 936156011962 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 936156011963 ribosome maturation protein RimP; Reviewed; Region: PRK00092 936156011964 Sm and related proteins; Region: Sm_like; cl00259 936156011965 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 936156011966 putative oligomer interface [polypeptide binding]; other site 936156011967 putative RNA binding site [nucleotide binding]; other site 936156011968 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 936156011969 NusA N-terminal domain; Region: NusA_N; pfam08529 936156011970 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 936156011971 RNA binding site [nucleotide binding]; other site 936156011972 homodimer interface [polypeptide binding]; other site 936156011973 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 936156011974 G-X-X-G motif; other site 936156011975 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 936156011976 G-X-X-G motif; other site 936156011977 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 936156011978 putative RNA binding cleft [nucleotide binding]; other site 936156011979 hypothetical protein; Provisional; Region: PRK07714 936156011980 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 936156011981 translation initiation factor IF-2; Region: IF-2; TIGR00487 936156011982 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 936156011983 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 936156011984 G1 box; other site 936156011985 putative GEF interaction site [polypeptide binding]; other site 936156011986 GTP/Mg2+ binding site [chemical binding]; other site 936156011987 Switch I region; other site 936156011988 G2 box; other site 936156011989 G3 box; other site 936156011990 Switch II region; other site 936156011991 G4 box; other site 936156011992 G5 box; other site 936156011993 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 936156011994 Translation-initiation factor 2; Region: IF-2; pfam11987 936156011995 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 936156011996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 936156011997 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 936156011998 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 936156011999 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 936156012000 RNA binding site [nucleotide binding]; other site 936156012001 active site 936156012002 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 936156012003 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 936156012004 active site 936156012005 Riboflavin kinase; Region: Flavokinase; smart00904 936156012006 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 936156012007 16S/18S rRNA binding site [nucleotide binding]; other site 936156012008 S13e-L30e interaction site [polypeptide binding]; other site 936156012009 25S rRNA binding site [nucleotide binding]; other site 936156012010 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 936156012011 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 936156012012 RNase E interface [polypeptide binding]; other site 936156012013 trimer interface [polypeptide binding]; other site 936156012014 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 936156012015 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 936156012016 RNase E interface [polypeptide binding]; other site 936156012017 trimer interface [polypeptide binding]; other site 936156012018 active site 936156012019 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 936156012020 putative nucleic acid binding region [nucleotide binding]; other site 936156012021 G-X-X-G motif; other site 936156012022 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 936156012023 RNA binding site [nucleotide binding]; other site 936156012024 domain interface; other site 936156012025 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 936156012026 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 936156012027 NodB motif; other site 936156012028 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 936156012029 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 936156012030 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 936156012031 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 936156012032 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 936156012033 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 936156012034 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 936156012035 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 936156012036 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 936156012037 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 936156012038 aspartate kinase I; Reviewed; Region: PRK08210 936156012039 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 936156012040 putative catalytic residues [active] 936156012041 putative nucleotide binding site [chemical binding]; other site 936156012042 putative aspartate binding site [chemical binding]; other site 936156012043 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 936156012044 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 936156012045 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 936156012046 dihydrodipicolinate synthase; Region: dapA; TIGR00674 936156012047 dimer interface [polypeptide binding]; other site 936156012048 active site 936156012049 catalytic residue [active] 936156012050 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 936156012051 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 936156012052 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 936156012053 Clp protease; Region: CLP_protease; pfam00574 936156012054 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 936156012055 active site 936156012056 YlzJ-like protein; Region: YlzJ; pfam14035 936156012057 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 936156012058 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 936156012059 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 936156012060 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 936156012061 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 936156012062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936156012063 DNA-binding site [nucleotide binding]; DNA binding site 936156012064 UTRA domain; Region: UTRA; pfam07702 936156012065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936156012066 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936156012067 putative substrate translocation pore; other site 936156012068 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 936156012069 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 936156012070 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 936156012071 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 936156012072 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 936156012073 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 936156012074 classical (c) SDRs; Region: SDR_c; cd05233 936156012075 NAD(P) binding site [chemical binding]; other site 936156012076 active site 936156012077 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 936156012078 ACT domain; Region: ACT; pfam01842 936156012079 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 936156012080 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 936156012081 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936156012082 non-specific DNA binding site [nucleotide binding]; other site 936156012083 salt bridge; other site 936156012084 sequence-specific DNA binding site [nucleotide binding]; other site 936156012085 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 936156012086 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 936156012087 competence damage-inducible protein A; Provisional; Region: PRK00549 936156012088 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 936156012089 putative MPT binding site; other site 936156012090 competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199 936156012091 recombinase A; Provisional; Region: recA; PRK09354 936156012092 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 936156012093 hexamer interface [polypeptide binding]; other site 936156012094 Walker A motif; other site 936156012095 ATP binding site [chemical binding]; other site 936156012096 Walker B motif; other site 936156012097 Beta-lactamase; Region: Beta-lactamase; pfam00144 936156012098 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 936156012099 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 936156012100 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 936156012101 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936156012102 Zn2+ binding site [ion binding]; other site 936156012103 Mg2+ binding site [ion binding]; other site 936156012104 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 936156012105 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 936156012106 putative active site [active] 936156012107 metal binding site [ion binding]; metal-binding site 936156012108 homodimer binding site [polypeptide binding]; other site 936156012109 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 936156012110 Threonine dehydrogenase; Region: TDH; cd05281 936156012111 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 936156012112 structural Zn binding site [ion binding]; other site 936156012113 catalytic Zn binding site [ion binding]; other site 936156012114 tetramer interface [polypeptide binding]; other site 936156012115 NADP binding site [chemical binding]; other site 936156012116 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 936156012117 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 936156012118 substrate-cofactor binding pocket; other site 936156012119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936156012120 catalytic residue [active] 936156012121 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 936156012122 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 936156012123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936156012124 FeS/SAM binding site; other site 936156012125 TRAM domain; Region: TRAM; pfam01938 936156012126 Predicted membrane protein [Function unknown]; Region: COG4550 936156012127 Outer spore coat protein E (CotE); Region: CotE; pfam10628 936156012128 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 936156012129 MutS domain I; Region: MutS_I; pfam01624 936156012130 MutS domain II; Region: MutS_II; pfam05188 936156012131 MutS domain III; Region: MutS_III; pfam05192 936156012132 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 936156012133 Walker A/P-loop; other site 936156012134 ATP binding site [chemical binding]; other site 936156012135 Q-loop/lid; other site 936156012136 ABC transporter signature motif; other site 936156012137 Walker B; other site 936156012138 D-loop; other site 936156012139 H-loop/switch region; other site 936156012140 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 936156012141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936156012142 ATP binding site [chemical binding]; other site 936156012143 Mg2+ binding site [ion binding]; other site 936156012144 G-X-G motif; other site 936156012145 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 936156012146 ATP binding site [chemical binding]; other site 936156012147 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 936156012148 Regulatory protein YrvL; Region: YrvL; pfam14184 936156012149 transcriptional regulator BetI; Validated; Region: PRK00767 936156012150 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936156012151 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 936156012152 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 936156012153 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 936156012154 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 936156012155 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 936156012156 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 936156012157 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 936156012158 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 936156012159 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 936156012160 FMN binding site [chemical binding]; other site 936156012161 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 936156012162 substrate binding site [chemical binding]; other site 936156012163 putative catalytic residue [active] 936156012164 acyl carrier protein; Validated; Region: PRK07117 936156012165 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 936156012166 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 936156012167 dimer interface [polypeptide binding]; other site 936156012168 active site 936156012169 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 936156012170 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 936156012171 dimer interface [polypeptide binding]; other site 936156012172 active site 936156012173 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 936156012174 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 936156012175 substrate binding site [chemical binding]; other site 936156012176 oxyanion hole (OAH) forming residues; other site 936156012177 trimer interface [polypeptide binding]; other site 936156012178 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 936156012179 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 936156012180 substrate binding site [chemical binding]; other site 936156012181 oxyanion hole (OAH) forming residues; other site 936156012182 trimer interface [polypeptide binding]; other site 936156012183 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 936156012184 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 936156012185 acyl-activating enzyme (AAE) consensus motif; other site 936156012186 putative AMP binding site [chemical binding]; other site 936156012187 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156012188 Condensation domain; Region: Condensation; pfam00668 936156012189 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156012190 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 936156012191 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 936156012192 acyl-activating enzyme (AAE) consensus motif; other site 936156012193 AMP binding site [chemical binding]; other site 936156012194 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156012195 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 936156012196 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012197 active site 936156012198 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 936156012199 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 936156012200 KR domain; Region: KR; pfam08659 936156012201 putative NADP binding site [chemical binding]; other site 936156012202 active site 936156012203 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156012204 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 936156012205 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 936156012206 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012207 active site 936156012208 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 936156012209 putative NADP binding site [chemical binding]; other site 936156012210 active site 936156012211 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156012212 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012213 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 936156012214 active site 936156012215 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 936156012216 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156012217 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 936156012218 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012219 active site 936156012220 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 936156012221 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 936156012222 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 936156012223 putative NADP binding site [chemical binding]; other site 936156012224 active site 936156012225 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156012226 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012227 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 936156012228 active site 936156012229 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 936156012230 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 936156012231 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 936156012232 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012233 active site 936156012234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 936156012235 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 936156012236 putative NADP binding site [chemical binding]; other site 936156012237 active site 936156012238 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156012239 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012240 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 936156012241 active site 936156012242 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 936156012243 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 936156012244 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 936156012245 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012246 active site 936156012247 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 936156012248 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 936156012249 putative NADP binding site [chemical binding]; other site 936156012250 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 936156012251 active site 936156012252 Methyltransferase domain; Region: Methyltransf_12; pfam08242 936156012253 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156012254 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 936156012255 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012256 active site 936156012257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 936156012258 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 936156012259 putative NADP binding site [chemical binding]; other site 936156012260 active site 936156012261 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156012262 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012263 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 936156012264 active site 936156012265 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156012266 Condensation domain; Region: Condensation; pfam00668 936156012267 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936156012268 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 936156012269 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936156012270 acyl-activating enzyme (AAE) consensus motif; other site 936156012271 AMP binding site [chemical binding]; other site 936156012272 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156012273 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 936156012274 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012275 active site 936156012276 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 936156012277 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 936156012278 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 936156012279 putative NADP binding site [chemical binding]; other site 936156012280 active site 936156012281 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 936156012282 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 936156012283 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012284 active site 936156012285 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 936156012286 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 936156012287 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 936156012288 putative NADP binding site [chemical binding]; other site 936156012289 active site 936156012290 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 936156012291 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 936156012292 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012293 active site 936156012294 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 936156012295 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 936156012296 putative NADP binding site [chemical binding]; other site 936156012297 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 936156012298 active site 936156012299 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 936156012300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936156012301 S-adenosylmethionine binding site [chemical binding]; other site 936156012302 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156012303 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012304 active site 936156012305 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 936156012306 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936156012307 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 936156012308 active site 936156012309 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936156012310 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 936156012311 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 936156012312 Cytochrome P450; Region: p450; cl12078 936156012313 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 936156012314 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 936156012315 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 936156012316 active site 936156012317 catalytic triad [active] 936156012318 WYL domain; Region: WYL; cl14852 936156012319 Phage-related replication protein [General function prediction only]; Region: COG4195 936156012320 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 936156012321 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 936156012322 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 936156012323 YmaF family; Region: YmaF; pfam12788 936156012324 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 936156012325 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 936156012326 bacterial Hfq-like; Region: Hfq; cd01716 936156012327 hexamer interface [polypeptide binding]; other site 936156012328 Sm1 motif; other site 936156012329 RNA binding site [nucleotide binding]; other site 936156012330 Sm2 motif; other site 936156012331 YmzC-like protein; Region: YmzC; pfam14157 936156012332 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 936156012333 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 936156012334 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 936156012335 Class I ribonucleotide reductase; Region: RNR_I; cd01679 936156012336 active site 936156012337 dimer interface [polypeptide binding]; other site 936156012338 catalytic residues [active] 936156012339 effector binding site; other site 936156012340 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 936156012341 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 936156012342 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 936156012343 dimer interface [polypeptide binding]; other site 936156012344 putative radical transfer pathway; other site 936156012345 diiron center [ion binding]; other site 936156012346 tyrosyl radical; other site 936156012347 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 936156012348 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 936156012349 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 936156012350 active site 936156012351 metal binding site [ion binding]; metal-binding site 936156012352 Sporulation related domain; Region: SPOR; pfam05036 936156012353 stage V sporulation protein K; Region: spore_V_K; TIGR02881 936156012354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936156012355 Walker A motif; other site 936156012356 ATP binding site [chemical binding]; other site 936156012357 Walker B motif; other site 936156012358 arginine finger; other site 936156012359 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 936156012360 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 936156012361 HflX GTPase family; Region: HflX; cd01878 936156012362 G1 box; other site 936156012363 GTP/Mg2+ binding site [chemical binding]; other site 936156012364 Switch I region; other site 936156012365 G2 box; other site 936156012366 G3 box; other site 936156012367 Switch II region; other site 936156012368 G4 box; other site 936156012369 G5 box; other site 936156012370 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 936156012371 Aluminium resistance protein; Region: Alum_res; pfam06838 936156012372 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 936156012373 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 936156012374 DNA binding residues [nucleotide binding] 936156012375 putative dimer interface [polypeptide binding]; other site 936156012376 glutamine synthetase, type I; Region: GlnA; TIGR00653 936156012377 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 936156012378 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 936156012379 Uncharacterized conserved protein [Function unknown]; Region: COG5444