-- dump date 20140618_225226 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1415167000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1415167000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1415167000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167000004 Walker A motif; other site 1415167000005 ATP binding site [chemical binding]; other site 1415167000006 Walker B motif; other site 1415167000007 arginine finger; other site 1415167000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1415167000009 DnaA box-binding interface [nucleotide binding]; other site 1415167000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1415167000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1415167000012 putative DNA binding surface [nucleotide binding]; other site 1415167000013 dimer interface [polypeptide binding]; other site 1415167000014 beta-clamp/clamp loader binding surface; other site 1415167000015 beta-clamp/translesion DNA polymerase binding surface; other site 1415167000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1415167000017 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 1415167000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1415167000019 Walker A/P-loop; other site 1415167000020 ATP binding site [chemical binding]; other site 1415167000021 Q-loop/lid; other site 1415167000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1415167000023 ABC transporter signature motif; other site 1415167000024 Walker B; other site 1415167000025 D-loop; other site 1415167000026 H-loop/switch region; other site 1415167000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1415167000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167000029 ATP binding site [chemical binding]; other site 1415167000030 Mg2+ binding site [ion binding]; other site 1415167000031 G-X-G motif; other site 1415167000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1415167000033 anchoring element; other site 1415167000034 dimer interface [polypeptide binding]; other site 1415167000035 ATP binding site [chemical binding]; other site 1415167000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1415167000037 active site 1415167000038 putative metal-binding site [ion binding]; other site 1415167000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1415167000040 DNA gyrase subunit A; Validated; Region: PRK05560 1415167000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1415167000042 CAP-like domain; other site 1415167000043 active site 1415167000044 primary dimer interface [polypeptide binding]; other site 1415167000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1415167000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1415167000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1415167000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1415167000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1415167000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1415167000051 YaaC-like Protein; Region: YaaC; pfam14175 1415167000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1415167000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1415167000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1415167000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1415167000056 active site 1415167000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1415167000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1415167000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1415167000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1415167000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1415167000062 active site 1415167000063 multimer interface [polypeptide binding]; other site 1415167000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1415167000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1415167000066 predicted active site [active] 1415167000067 catalytic triad [active] 1415167000068 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1415167000069 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1415167000070 Substrate-binding site [chemical binding]; other site 1415167000071 Substrate specificity [chemical binding]; other site 1415167000072 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1415167000073 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167000074 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167000075 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1415167000076 active site 1415167000077 Isochorismatase family; Region: Isochorismatase; pfam00857 1415167000078 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1415167000079 catalytic triad [active] 1415167000080 conserved cis-peptide bond; other site 1415167000081 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1415167000082 nucleoside/Zn binding site; other site 1415167000083 dimer interface [polypeptide binding]; other site 1415167000084 catalytic motif [active] 1415167000085 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1415167000086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167000087 Walker A motif; other site 1415167000088 ATP binding site [chemical binding]; other site 1415167000089 Walker B motif; other site 1415167000090 arginine finger; other site 1415167000091 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1415167000092 hypothetical protein; Validated; Region: PRK00153 1415167000093 recombination protein RecR; Reviewed; Region: recR; PRK00076 1415167000094 RecR protein; Region: RecR; pfam02132 1415167000095 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1415167000096 putative active site [active] 1415167000097 putative metal-binding site [ion binding]; other site 1415167000098 tetramer interface [polypeptide binding]; other site 1415167000099 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1415167000100 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 1415167000101 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1415167000102 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1415167000103 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1415167000104 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 1415167000105 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1415167000106 homodimer interface [polypeptide binding]; other site 1415167000107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167000108 catalytic residue [active] 1415167000109 thymidylate kinase; Validated; Region: tmk; PRK00698 1415167000110 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1415167000111 TMP-binding site; other site 1415167000112 ATP-binding site [chemical binding]; other site 1415167000113 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1415167000114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 1415167000115 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1415167000116 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1415167000117 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1415167000118 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1415167000119 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1415167000120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167000121 S-adenosylmethionine binding site [chemical binding]; other site 1415167000122 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1415167000123 putative metal binding site [ion binding]; other site 1415167000124 Predicted methyltransferases [General function prediction only]; Region: COG0313 1415167000125 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1415167000126 putative SAM binding site [chemical binding]; other site 1415167000127 putative homodimer interface [polypeptide binding]; other site 1415167000128 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1415167000129 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1415167000130 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1415167000131 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1415167000132 active site 1415167000133 HIGH motif; other site 1415167000134 KMSKS motif; other site 1415167000135 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1415167000136 tRNA binding surface [nucleotide binding]; other site 1415167000137 anticodon binding site; other site 1415167000138 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1415167000139 dimer interface [polypeptide binding]; other site 1415167000140 putative tRNA-binding site [nucleotide binding]; other site 1415167000141 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1415167000142 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1415167000143 active site 1415167000144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1415167000145 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1415167000146 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1415167000147 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1415167000148 G5 domain; Region: G5; pfam07501 1415167000149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1415167000150 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1415167000151 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1415167000152 putative active site [active] 1415167000153 putative metal binding site [ion binding]; other site 1415167000154 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1415167000155 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1415167000156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167000157 S-adenosylmethionine binding site [chemical binding]; other site 1415167000158 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 1415167000159 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1415167000160 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1415167000161 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1415167000162 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1415167000163 pur operon repressor; Provisional; Region: PRK09213 1415167000164 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1415167000165 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1415167000166 active site 1415167000167 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1415167000168 homotrimer interaction site [polypeptide binding]; other site 1415167000169 putative active site [active] 1415167000170 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1415167000171 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1415167000172 Substrate binding site; other site 1415167000173 Mg++ binding site; other site 1415167000174 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1415167000175 active site 1415167000176 substrate binding site [chemical binding]; other site 1415167000177 CoA binding site [chemical binding]; other site 1415167000178 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1415167000179 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1415167000180 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1415167000181 active site 1415167000182 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1415167000183 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1415167000184 5S rRNA interface [nucleotide binding]; other site 1415167000185 CTC domain interface [polypeptide binding]; other site 1415167000186 L16 interface [polypeptide binding]; other site 1415167000187 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1415167000188 putative active site [active] 1415167000189 catalytic residue [active] 1415167000190 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1415167000191 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1415167000192 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1415167000193 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1415167000194 ATP binding site [chemical binding]; other site 1415167000195 putative Mg++ binding site [ion binding]; other site 1415167000196 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167000197 nucleotide binding region [chemical binding]; other site 1415167000198 ATP-binding site [chemical binding]; other site 1415167000199 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1415167000200 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1415167000201 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1415167000202 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1415167000203 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1415167000204 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1415167000205 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1415167000206 putative SAM binding site [chemical binding]; other site 1415167000207 putative homodimer interface [polypeptide binding]; other site 1415167000208 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1415167000209 homodimer interface [polypeptide binding]; other site 1415167000210 metal binding site [ion binding]; metal-binding site 1415167000211 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1415167000212 homodimer interface [polypeptide binding]; other site 1415167000213 active site 1415167000214 putative chemical substrate binding site [chemical binding]; other site 1415167000215 metal binding site [ion binding]; metal-binding site 1415167000216 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1415167000217 RNA binding surface [nucleotide binding]; other site 1415167000218 sporulation protein YabP; Region: spore_yabP; TIGR02892 1415167000219 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1415167000220 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1415167000221 Septum formation initiator; Region: DivIC; pfam04977 1415167000222 hypothetical protein; Provisional; Region: PRK08582 1415167000223 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1415167000224 RNA binding site [nucleotide binding]; other site 1415167000225 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1415167000226 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1415167000227 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1415167000228 metal ion-dependent adhesion site (MIDAS); other site 1415167000229 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1415167000230 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1415167000231 active site 1415167000232 ATP binding site [chemical binding]; other site 1415167000233 substrate binding site [chemical binding]; other site 1415167000234 activation loop (A-loop); other site 1415167000235 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1415167000236 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1415167000237 Ligand Binding Site [chemical binding]; other site 1415167000238 TilS substrate binding domain; Region: TilS; pfam09179 1415167000239 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1415167000240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1415167000241 active site 1415167000242 FtsH Extracellular; Region: FtsH_ext; pfam06480 1415167000243 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1415167000244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167000245 Walker A motif; other site 1415167000246 ATP binding site [chemical binding]; other site 1415167000247 Walker B motif; other site 1415167000248 arginine finger; other site 1415167000249 Peptidase family M41; Region: Peptidase_M41; pfam01434 1415167000250 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1415167000251 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1415167000252 dimerization interface [polypeptide binding]; other site 1415167000253 domain crossover interface; other site 1415167000254 redox-dependent activation switch; other site 1415167000255 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1415167000256 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1415167000257 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1415167000258 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1415167000259 dimer interface [polypeptide binding]; other site 1415167000260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167000261 catalytic residue [active] 1415167000262 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1415167000263 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1415167000264 glutamine binding [chemical binding]; other site 1415167000265 catalytic triad [active] 1415167000266 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1415167000267 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1415167000268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167000269 catalytic residue [active] 1415167000270 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1415167000271 dihydropteroate synthase; Region: DHPS; TIGR01496 1415167000272 substrate binding pocket [chemical binding]; other site 1415167000273 dimer interface [polypeptide binding]; other site 1415167000274 inhibitor binding site; inhibition site 1415167000275 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1415167000276 homooctamer interface [polypeptide binding]; other site 1415167000277 active site 1415167000278 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1415167000279 catalytic center binding site [active] 1415167000280 ATP binding site [chemical binding]; other site 1415167000281 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1415167000282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167000283 non-specific DNA binding site [nucleotide binding]; other site 1415167000284 salt bridge; other site 1415167000285 sequence-specific DNA binding site [nucleotide binding]; other site 1415167000286 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1415167000287 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1415167000288 FMN binding site [chemical binding]; other site 1415167000289 active site 1415167000290 catalytic residues [active] 1415167000291 substrate binding site [chemical binding]; other site 1415167000292 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1415167000293 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1415167000294 dimer interface [polypeptide binding]; other site 1415167000295 putative anticodon binding site; other site 1415167000296 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1415167000297 motif 1; other site 1415167000298 active site 1415167000299 motif 2; other site 1415167000300 motif 3; other site 1415167000301 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1415167000302 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1415167000303 UvrB/uvrC motif; Region: UVR; pfam02151 1415167000304 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1415167000305 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1415167000306 ADP binding site [chemical binding]; other site 1415167000307 phosphagen binding site; other site 1415167000308 substrate specificity loop; other site 1415167000309 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1415167000310 Clp amino terminal domain; Region: Clp_N; pfam02861 1415167000311 Clp amino terminal domain; Region: Clp_N; pfam02861 1415167000312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167000313 Walker A motif; other site 1415167000314 ATP binding site [chemical binding]; other site 1415167000315 Walker B motif; other site 1415167000316 arginine finger; other site 1415167000317 UvrB/uvrC motif; Region: UVR; pfam02151 1415167000318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167000319 Walker A motif; other site 1415167000320 ATP binding site [chemical binding]; other site 1415167000321 Walker B motif; other site 1415167000322 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1415167000323 DNA repair protein RadA; Provisional; Region: PRK11823 1415167000324 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1415167000325 Walker A motif/ATP binding site; other site 1415167000326 ATP binding site [chemical binding]; other site 1415167000327 Walker B motif; other site 1415167000328 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1415167000329 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1415167000330 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1415167000331 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1415167000332 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1415167000333 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1415167000334 putative active site [active] 1415167000335 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1415167000336 substrate binding site; other site 1415167000337 dimer interface; other site 1415167000338 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1415167000339 homotrimer interaction site [polypeptide binding]; other site 1415167000340 zinc binding site [ion binding]; other site 1415167000341 CDP-binding sites; other site 1415167000342 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1415167000343 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1415167000344 active site 1415167000345 HIGH motif; other site 1415167000346 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1415167000347 active site 1415167000348 KMSKS motif; other site 1415167000349 serine O-acetyltransferase; Region: cysE; TIGR01172 1415167000350 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1415167000351 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1415167000352 trimer interface [polypeptide binding]; other site 1415167000353 active site 1415167000354 substrate binding site [chemical binding]; other site 1415167000355 CoA binding site [chemical binding]; other site 1415167000356 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1415167000357 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1415167000358 active site 1415167000359 HIGH motif; other site 1415167000360 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1415167000361 KMSKS motif; other site 1415167000362 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1415167000363 tRNA binding surface [nucleotide binding]; other site 1415167000364 anticodon binding site; other site 1415167000365 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1415167000366 active site 1415167000367 metal binding site [ion binding]; metal-binding site 1415167000368 dimerization interface [polypeptide binding]; other site 1415167000369 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1415167000370 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1415167000371 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1415167000372 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1415167000373 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1415167000374 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1415167000375 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1415167000376 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1415167000377 putative homodimer interface [polypeptide binding]; other site 1415167000378 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1415167000379 heterodimer interface [polypeptide binding]; other site 1415167000380 homodimer interface [polypeptide binding]; other site 1415167000381 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1415167000382 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1415167000383 23S rRNA interface [nucleotide binding]; other site 1415167000384 L7/L12 interface [polypeptide binding]; other site 1415167000385 putative thiostrepton binding site; other site 1415167000386 L25 interface [polypeptide binding]; other site 1415167000387 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1415167000388 mRNA/rRNA interface [nucleotide binding]; other site 1415167000389 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1415167000390 23S rRNA interface [nucleotide binding]; other site 1415167000391 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1415167000392 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1415167000393 core dimer interface [polypeptide binding]; other site 1415167000394 peripheral dimer interface [polypeptide binding]; other site 1415167000395 L10 interface [polypeptide binding]; other site 1415167000396 L11 interface [polypeptide binding]; other site 1415167000397 putative EF-Tu interaction site [polypeptide binding]; other site 1415167000398 putative EF-G interaction site [polypeptide binding]; other site 1415167000399 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1415167000400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167000401 S-adenosylmethionine binding site [chemical binding]; other site 1415167000402 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1415167000403 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1415167000404 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1415167000405 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1415167000406 RPB1 interaction site [polypeptide binding]; other site 1415167000407 RPB10 interaction site [polypeptide binding]; other site 1415167000408 RPB11 interaction site [polypeptide binding]; other site 1415167000409 RPB3 interaction site [polypeptide binding]; other site 1415167000410 RPB12 interaction site [polypeptide binding]; other site 1415167000411 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1415167000412 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1415167000413 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1415167000414 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1415167000415 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1415167000416 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1415167000417 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1415167000418 G-loop; other site 1415167000419 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1415167000420 DNA binding site [nucleotide binding] 1415167000421 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1415167000422 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1415167000423 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1415167000424 S17 interaction site [polypeptide binding]; other site 1415167000425 S8 interaction site; other site 1415167000426 16S rRNA interaction site [nucleotide binding]; other site 1415167000427 streptomycin interaction site [chemical binding]; other site 1415167000428 23S rRNA interaction site [nucleotide binding]; other site 1415167000429 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1415167000430 30S ribosomal protein S7; Validated; Region: PRK05302 1415167000431 elongation factor G; Reviewed; Region: PRK00007 1415167000432 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1415167000433 Switch I region; other site 1415167000434 G2 box; other site 1415167000435 putative GEF interaction site [polypeptide binding]; other site 1415167000436 G3 box; other site 1415167000437 Switch II region; other site 1415167000438 GTP/Mg2+ binding site [chemical binding]; other site 1415167000439 G4 box; other site 1415167000440 G5 box; other site 1415167000441 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1415167000442 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1415167000443 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1415167000444 elongation factor Tu; Reviewed; Region: PRK00049 1415167000445 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1415167000446 G1 box; other site 1415167000447 GEF interaction site [polypeptide binding]; other site 1415167000448 GTP/Mg2+ binding site [chemical binding]; other site 1415167000449 Switch I region; other site 1415167000450 G2 box; other site 1415167000451 G3 box; other site 1415167000452 Switch II region; other site 1415167000453 G4 box; other site 1415167000454 G5 box; other site 1415167000455 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1415167000456 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1415167000457 Antibiotic Binding Site [chemical binding]; other site 1415167000458 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1415167000459 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1415167000460 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1415167000461 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1415167000462 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1415167000463 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1415167000464 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1415167000465 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1415167000466 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1415167000467 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1415167000468 putative translocon binding site; other site 1415167000469 protein-rRNA interface [nucleotide binding]; other site 1415167000470 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1415167000471 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1415167000472 G-X-X-G motif; other site 1415167000473 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1415167000474 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1415167000475 L27 interface [polypeptide binding]; other site 1415167000476 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1415167000477 23S rRNA interface [nucleotide binding]; other site 1415167000478 putative translocon interaction site; other site 1415167000479 signal recognition particle (SRP54) interaction site; other site 1415167000480 L23 interface [polypeptide binding]; other site 1415167000481 trigger factor interaction site; other site 1415167000482 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1415167000483 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1415167000484 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1415167000485 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1415167000486 RNA binding site [nucleotide binding]; other site 1415167000487 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1415167000488 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1415167000489 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1415167000490 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1415167000491 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1415167000492 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1415167000493 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1415167000494 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1415167000495 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1415167000496 5S rRNA interface [nucleotide binding]; other site 1415167000497 L27 interface [polypeptide binding]; other site 1415167000498 23S rRNA interface [nucleotide binding]; other site 1415167000499 L5 interface [polypeptide binding]; other site 1415167000500 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1415167000501 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1415167000502 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1415167000503 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1415167000504 23S rRNA binding site [nucleotide binding]; other site 1415167000505 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1415167000506 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1415167000507 SecY translocase; Region: SecY; pfam00344 1415167000508 adenylate kinase; Reviewed; Region: adk; PRK00279 1415167000509 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1415167000510 AMP-binding site [chemical binding]; other site 1415167000511 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1415167000512 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1415167000513 active site 1415167000514 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 1415167000515 RNA binding site [nucleotide binding]; other site 1415167000516 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1415167000517 rRNA binding site [nucleotide binding]; other site 1415167000518 predicted 30S ribosome binding site; other site 1415167000519 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1415167000520 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1415167000521 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1415167000522 30S ribosomal protein S11; Validated; Region: PRK05309 1415167000523 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1415167000524 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1415167000525 alphaNTD homodimer interface [polypeptide binding]; other site 1415167000526 alphaNTD - beta interaction site [polypeptide binding]; other site 1415167000527 alphaNTD - beta' interaction site [polypeptide binding]; other site 1415167000528 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1415167000529 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1415167000530 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1415167000531 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1415167000532 Walker A/P-loop; other site 1415167000533 ATP binding site [chemical binding]; other site 1415167000534 Q-loop/lid; other site 1415167000535 ABC transporter signature motif; other site 1415167000536 Walker B; other site 1415167000537 D-loop; other site 1415167000538 H-loop/switch region; other site 1415167000539 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1415167000540 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1415167000541 Walker A/P-loop; other site 1415167000542 ATP binding site [chemical binding]; other site 1415167000543 Q-loop/lid; other site 1415167000544 ABC transporter signature motif; other site 1415167000545 Walker B; other site 1415167000546 D-loop; other site 1415167000547 H-loop/switch region; other site 1415167000548 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1415167000549 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1415167000550 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1415167000551 dimerization interface 3.5A [polypeptide binding]; other site 1415167000552 active site 1415167000553 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1415167000554 23S rRNA interface [nucleotide binding]; other site 1415167000555 L3 interface [polypeptide binding]; other site 1415167000556 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1415167000557 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1415167000558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167000559 S-adenosylmethionine binding site [chemical binding]; other site 1415167000560 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1415167000561 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1415167000562 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1415167000563 active site 1415167000564 metal binding site [ion binding]; metal-binding site 1415167000565 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1415167000566 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1415167000567 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1415167000568 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1415167000569 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 1415167000570 NodB motif; other site 1415167000571 putative active site [active] 1415167000572 putative catalytic site [active] 1415167000573 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1415167000574 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1415167000575 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1415167000576 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1415167000577 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1415167000578 Sodium Bile acid symporter family; Region: SBF; cl17470 1415167000579 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1415167000580 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167000581 dimer interface [polypeptide binding]; other site 1415167000582 putative PBP binding regions; other site 1415167000583 ABC-ATPase subunit interface; other site 1415167000584 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1415167000585 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1415167000586 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167000587 ABC-ATPase subunit interface; other site 1415167000588 dimer interface [polypeptide binding]; other site 1415167000589 putative PBP binding regions; other site 1415167000590 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1415167000591 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1415167000592 putative ligand binding residues [chemical binding]; other site 1415167000593 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1415167000594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167000595 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1415167000596 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1415167000597 putative ligand binding residues [chemical binding]; other site 1415167000598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 1415167000599 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1415167000600 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1415167000601 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1415167000602 putative periplasmic esterase; Provisional; Region: PRK03642 1415167000603 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1415167000604 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1415167000605 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1415167000606 active site turn [active] 1415167000607 phosphorylation site [posttranslational modification] 1415167000608 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1415167000609 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1415167000610 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1415167000611 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1415167000612 putative active site [active] 1415167000613 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 1415167000614 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1415167000615 putative active site [active] 1415167000616 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1415167000617 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1415167000618 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1415167000619 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167000620 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167000621 DNA binding residues [nucleotide binding] 1415167000622 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1415167000623 Putative zinc-finger; Region: zf-HC2; pfam13490 1415167000624 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1415167000625 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1415167000626 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1415167000627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1415167000628 YbbR-like protein; Region: YbbR; pfam07949 1415167000629 YbbR-like protein; Region: YbbR; pfam07949 1415167000630 YbbR-like protein; Region: YbbR; pfam07949 1415167000631 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1415167000632 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1415167000633 active site 1415167000634 substrate binding site [chemical binding]; other site 1415167000635 metal binding site [ion binding]; metal-binding site 1415167000636 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1415167000637 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1415167000638 glutaminase active site [active] 1415167000639 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1415167000640 dimer interface [polypeptide binding]; other site 1415167000641 active site 1415167000642 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1415167000643 dimer interface [polypeptide binding]; other site 1415167000644 active site 1415167000645 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 1415167000646 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1415167000647 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1415167000648 minor groove reading motif; other site 1415167000649 helix-hairpin-helix signature motif; other site 1415167000650 substrate binding pocket [chemical binding]; other site 1415167000651 active site 1415167000652 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1415167000653 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1415167000654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167000655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167000656 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1415167000657 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1415167000658 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1415167000659 DNA binding site [nucleotide binding] 1415167000660 active site 1415167000661 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1415167000662 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1415167000663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1415167000664 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1415167000665 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1415167000666 zinc binding site [ion binding]; other site 1415167000667 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1415167000668 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167000669 dimerization interface [polypeptide binding]; other site 1415167000670 putative DNA binding site [nucleotide binding]; other site 1415167000671 putative Zn2+ binding site [ion binding]; other site 1415167000672 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1415167000673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167000674 putative substrate translocation pore; other site 1415167000675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167000676 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1415167000677 FeS/SAM binding site; other site 1415167000678 CAAX protease self-immunity; Region: Abi; pfam02517 1415167000679 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1415167000680 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1415167000681 Walker A/P-loop; other site 1415167000682 ATP binding site [chemical binding]; other site 1415167000683 Q-loop/lid; other site 1415167000684 ABC transporter signature motif; other site 1415167000685 Walker B; other site 1415167000686 D-loop; other site 1415167000687 H-loop/switch region; other site 1415167000688 HEAT repeats; Region: HEAT_2; pfam13646 1415167000689 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1415167000690 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1415167000691 catalytic residues [active] 1415167000692 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1415167000693 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1415167000694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167000695 active site 1415167000696 phosphorylation site [posttranslational modification] 1415167000697 intermolecular recognition site; other site 1415167000698 dimerization interface [polypeptide binding]; other site 1415167000699 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1415167000700 DNA binding site [nucleotide binding] 1415167000701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1415167000702 HAMP domain; Region: HAMP; pfam00672 1415167000703 dimerization interface [polypeptide binding]; other site 1415167000704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167000705 dimer interface [polypeptide binding]; other site 1415167000706 phosphorylation site [posttranslational modification] 1415167000707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167000708 ATP binding site [chemical binding]; other site 1415167000709 Mg2+ binding site [ion binding]; other site 1415167000710 G-X-G motif; other site 1415167000711 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1415167000712 active site 1415167000713 ATP binding site [chemical binding]; other site 1415167000714 substrate binding site [chemical binding]; other site 1415167000715 activation loop (A-loop); other site 1415167000716 putative transport protein YifK; Provisional; Region: PRK10746 1415167000717 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1415167000718 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1415167000719 Cytochrome P450; Region: p450; cl12078 1415167000720 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1415167000721 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1415167000722 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1415167000723 active site 1415167000724 catalytic site [active] 1415167000725 metal binding site [ion binding]; metal-binding site 1415167000726 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1415167000727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167000728 putative substrate translocation pore; other site 1415167000729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167000730 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1415167000731 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167000732 MarR family; Region: MarR; pfam01047 1415167000733 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1415167000734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167000735 Coenzyme A binding pocket [chemical binding]; other site 1415167000736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167000737 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167000738 putative substrate translocation pore; other site 1415167000739 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1415167000740 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1415167000741 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1415167000742 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1415167000743 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1415167000744 active site 1415167000745 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1415167000746 EamA-like transporter family; Region: EamA; pfam00892 1415167000747 EamA-like transporter family; Region: EamA; pfam00892 1415167000748 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1415167000749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167000750 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1415167000751 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167000752 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1415167000753 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1415167000754 ATP-grasp domain; Region: ATP-grasp; pfam02222 1415167000755 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1415167000756 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1415167000757 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1415167000758 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1415167000759 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1415167000760 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1415167000761 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1415167000762 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1415167000763 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1415167000764 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1415167000765 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167000766 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1415167000767 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1415167000768 active site residue [active] 1415167000769 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1415167000770 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1415167000771 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1415167000772 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1415167000773 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1415167000774 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1415167000775 active site turn [active] 1415167000776 phosphorylation site [posttranslational modification] 1415167000777 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1415167000778 HPr interaction site; other site 1415167000779 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1415167000780 active site 1415167000781 phosphorylation site [posttranslational modification] 1415167000782 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1415167000783 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1415167000784 active site 1415167000785 trimer interface [polypeptide binding]; other site 1415167000786 allosteric site; other site 1415167000787 active site lid [active] 1415167000788 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1415167000789 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1415167000790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167000791 DNA-binding site [nucleotide binding]; DNA binding site 1415167000792 UTRA domain; Region: UTRA; pfam07702 1415167000793 Predicted integral membrane protein [Function unknown]; Region: COG5658 1415167000794 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1415167000795 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1415167000796 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1415167000797 homodimer interface [polypeptide binding]; other site 1415167000798 substrate-cofactor binding pocket; other site 1415167000799 catalytic residue [active] 1415167000800 S-methylmethionine transporter; Provisional; Region: PRK11387 1415167000801 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1415167000802 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1415167000803 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1415167000804 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1415167000805 glutaminase; Reviewed; Region: PRK12357 1415167000806 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1415167000807 Chorismate mutase type II; Region: CM_2; cl00693 1415167000808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1415167000809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167000810 ATP binding site [chemical binding]; other site 1415167000811 Mg2+ binding site [ion binding]; other site 1415167000812 G-X-G motif; other site 1415167000813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167000814 Response regulator receiver domain; Region: Response_reg; pfam00072 1415167000815 active site 1415167000816 phosphorylation site [posttranslational modification] 1415167000817 intermolecular recognition site; other site 1415167000818 dimerization interface [polypeptide binding]; other site 1415167000819 YcbB domain; Region: YcbB; pfam08664 1415167000820 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1415167000821 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1415167000822 putative active site [active] 1415167000823 catalytic residue [active] 1415167000824 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1415167000825 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1415167000826 NAD(P) binding site [chemical binding]; other site 1415167000827 catalytic residues [active] 1415167000828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167000829 D-galactonate transporter; Region: 2A0114; TIGR00893 1415167000830 putative substrate translocation pore; other site 1415167000831 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1415167000832 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1415167000833 active site 1415167000834 tetramer interface [polypeptide binding]; other site 1415167000835 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1415167000836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167000837 DNA-binding site [nucleotide binding]; DNA binding site 1415167000838 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1415167000839 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1415167000840 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1415167000841 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1415167000842 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1415167000843 putative active site [active] 1415167000844 putative substrate binding site [chemical binding]; other site 1415167000845 Phosphotransferase enzyme family; Region: APH; pfam01636 1415167000846 ATP binding site [chemical binding]; other site 1415167000847 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1415167000848 dodecamer interface 1 [polypeptide binding]; other site 1415167000849 dodecamer interface 2 [polypeptide binding]; other site 1415167000850 trimer interface [polypeptide binding]; other site 1415167000851 TRAP binding interface [polypeptide binding]; other site 1415167000852 Zn binding site [ion binding]; other site 1415167000853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1415167000854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167000855 active site 1415167000856 phosphorylation site [posttranslational modification] 1415167000857 intermolecular recognition site; other site 1415167000858 dimerization interface [polypeptide binding]; other site 1415167000859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1415167000860 DNA binding site [nucleotide binding] 1415167000861 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1415167000862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167000863 dimer interface [polypeptide binding]; other site 1415167000864 phosphorylation site [posttranslational modification] 1415167000865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167000866 ATP binding site [chemical binding]; other site 1415167000867 Mg2+ binding site [ion binding]; other site 1415167000868 G-X-G motif; other site 1415167000869 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1415167000870 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1415167000871 Walker A/P-loop; other site 1415167000872 ATP binding site [chemical binding]; other site 1415167000873 Q-loop/lid; other site 1415167000874 ABC transporter signature motif; other site 1415167000875 Walker B; other site 1415167000876 D-loop; other site 1415167000877 H-loop/switch region; other site 1415167000878 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1415167000879 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1415167000880 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1415167000881 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1415167000882 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1415167000883 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1415167000884 metal ion-dependent adhesion site (MIDAS); other site 1415167000885 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1415167000886 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1415167000887 putative active site [active] 1415167000888 putative metal binding site [ion binding]; other site 1415167000889 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1415167000890 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1415167000891 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1415167000892 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1415167000893 putative substrate binding pocket [chemical binding]; other site 1415167000894 AC domain interface; other site 1415167000895 catalytic triad [active] 1415167000896 AB domain interface; other site 1415167000897 interchain disulfide; other site 1415167000898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167000899 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167000900 putative substrate translocation pore; other site 1415167000901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167000902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167000903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167000904 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1415167000905 active site 1415167000906 homotetramer interface [polypeptide binding]; other site 1415167000907 homodimer interface [polypeptide binding]; other site 1415167000908 Lipase (class 2); Region: Lipase_2; pfam01674 1415167000909 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1415167000910 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1415167000911 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1415167000912 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1415167000913 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1415167000914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167000915 ATP binding site [chemical binding]; other site 1415167000916 Mg2+ binding site [ion binding]; other site 1415167000917 G-X-G motif; other site 1415167000918 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1415167000919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167000920 active site 1415167000921 phosphorylation site [posttranslational modification] 1415167000922 intermolecular recognition site; other site 1415167000923 dimerization interface [polypeptide binding]; other site 1415167000924 LytTr DNA-binding domain; Region: LytTR; pfam04397 1415167000925 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1415167000926 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 1415167000927 Walker A/P-loop; other site 1415167000928 ATP binding site [chemical binding]; other site 1415167000929 Q-loop/lid; other site 1415167000930 ABC transporter signature motif; other site 1415167000931 Walker B; other site 1415167000932 D-loop; other site 1415167000933 H-loop/switch region; other site 1415167000934 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1415167000935 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1415167000936 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1415167000937 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1415167000938 active site 1415167000939 catalytic tetrad [active] 1415167000940 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1415167000941 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1415167000942 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1415167000943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167000944 binding surface 1415167000945 TPR motif; other site 1415167000946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167000947 TPR motif; other site 1415167000948 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1415167000949 binding surface 1415167000950 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1415167000951 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1415167000952 NAD binding site [chemical binding]; other site 1415167000953 homodimer interface [polypeptide binding]; other site 1415167000954 active site 1415167000955 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1415167000956 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1415167000957 Ca binding site [ion binding]; other site 1415167000958 active site 1415167000959 catalytic site [active] 1415167000960 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1415167000961 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1415167000962 metal binding site [ion binding]; metal-binding site 1415167000963 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1415167000964 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1415167000965 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1415167000966 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167000967 ABC-ATPase subunit interface; other site 1415167000968 dimer interface [polypeptide binding]; other site 1415167000969 putative PBP binding regions; other site 1415167000970 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1415167000971 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1415167000972 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1415167000973 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1415167000974 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1415167000975 putative metal binding site [ion binding]; other site 1415167000976 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1415167000977 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1415167000978 putative metal binding site [ion binding]; other site 1415167000979 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1415167000980 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1415167000981 putative metal binding site [ion binding]; other site 1415167000982 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1415167000983 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1415167000984 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 1415167000985 benzoate transport; Region: 2A0115; TIGR00895 1415167000986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167000987 putative substrate translocation pore; other site 1415167000988 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1415167000989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167000990 putative substrate translocation pore; other site 1415167000991 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167000992 dimerization interface [polypeptide binding]; other site 1415167000993 putative DNA binding site [nucleotide binding]; other site 1415167000994 putative Zn2+ binding site [ion binding]; other site 1415167000995 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1415167000996 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1415167000997 Walker A/P-loop; other site 1415167000998 ATP binding site [chemical binding]; other site 1415167000999 Q-loop/lid; other site 1415167001000 ABC transporter signature motif; other site 1415167001001 Walker B; other site 1415167001002 D-loop; other site 1415167001003 H-loop/switch region; other site 1415167001004 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1415167001005 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1415167001006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167001007 dimer interface [polypeptide binding]; other site 1415167001008 conserved gate region; other site 1415167001009 putative PBP binding loops; other site 1415167001010 ABC-ATPase subunit interface; other site 1415167001011 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1415167001012 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1415167001013 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1415167001014 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1415167001015 amidohydrolase; Region: amidohydrolases; TIGR01891 1415167001016 metal binding site [ion binding]; metal-binding site 1415167001017 putative dimer interface [polypeptide binding]; other site 1415167001018 Predicted membrane protein [Function unknown]; Region: COG1288 1415167001019 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1415167001020 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1415167001021 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1415167001022 active site 1415167001023 Ca binding site [ion binding]; other site 1415167001024 catalytic site [active] 1415167001025 Aamy_C domain; Region: Aamy_C; smart00632 1415167001026 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1415167001027 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1415167001028 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1415167001029 NAD binding site [chemical binding]; other site 1415167001030 dimer interface [polypeptide binding]; other site 1415167001031 substrate binding site [chemical binding]; other site 1415167001032 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1415167001033 L-lactate permease; Region: Lactate_perm; pfam02652 1415167001034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167001036 putative substrate translocation pore; other site 1415167001037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001038 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167001039 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167001040 putative DNA binding site [nucleotide binding]; other site 1415167001041 putative Zn2+ binding site [ion binding]; other site 1415167001042 LysE type translocator; Region: LysE; pfam01810 1415167001043 Uncharacterized conserved protein [Function unknown]; Region: COG3403 1415167001044 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1415167001045 Spore germination protein; Region: Spore_permease; cl17796 1415167001046 NAD+ synthetase; Region: nadE; TIGR00552 1415167001047 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1415167001048 homodimer interface [polypeptide binding]; other site 1415167001049 NAD binding pocket [chemical binding]; other site 1415167001050 ATP binding pocket [chemical binding]; other site 1415167001051 Mg binding site [ion binding]; other site 1415167001052 active-site loop [active] 1415167001053 AAA domain; Region: AAA_17; cl17253 1415167001054 AAA domain; Region: AAA_18; pfam13238 1415167001055 shikimate kinase; Reviewed; Region: aroK; PRK00131 1415167001056 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1415167001057 ADP binding site [chemical binding]; other site 1415167001058 magnesium binding site [ion binding]; other site 1415167001059 putative shikimate binding site; other site 1415167001060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167001061 S-adenosylmethionine binding site [chemical binding]; other site 1415167001062 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167001063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167001064 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1415167001065 dimerization interface [polypeptide binding]; other site 1415167001066 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1415167001067 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1415167001068 Proline dehydrogenase; Region: Pro_dh; pfam01619 1415167001069 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1415167001070 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1415167001071 Glutamate binding site [chemical binding]; other site 1415167001072 homodimer interface [polypeptide binding]; other site 1415167001073 NAD binding site [chemical binding]; other site 1415167001074 catalytic residues [active] 1415167001075 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1415167001076 Na binding site [ion binding]; other site 1415167001077 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1415167001078 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1415167001079 Predicted membrane protein [Function unknown]; Region: COG3689 1415167001080 Predicted permeases [General function prediction only]; Region: COG0701 1415167001081 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1415167001082 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1415167001083 active site 1415167001084 SAM binding site [chemical binding]; other site 1415167001085 homodimer interface [polypeptide binding]; other site 1415167001086 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1415167001087 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1415167001088 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1415167001089 [2Fe-2S] cluster binding site [ion binding]; other site 1415167001090 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1415167001091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1415167001092 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1415167001093 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1415167001094 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1415167001095 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1415167001096 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1415167001097 [4Fe-4S] binding site [ion binding]; other site 1415167001098 molybdopterin cofactor binding site; other site 1415167001099 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1415167001100 molybdopterin cofactor binding site; other site 1415167001101 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1415167001102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1415167001103 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1415167001104 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1415167001105 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1415167001106 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1415167001107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001108 putative substrate translocation pore; other site 1415167001109 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 1415167001110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1415167001111 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1415167001112 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1415167001113 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1415167001114 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1415167001115 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1415167001116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167001117 dimer interface [polypeptide binding]; other site 1415167001118 conserved gate region; other site 1415167001119 putative PBP binding loops; other site 1415167001120 ABC-ATPase subunit interface; other site 1415167001121 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1415167001122 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1415167001123 substrate binding pocket [chemical binding]; other site 1415167001124 membrane-bound complex binding site; other site 1415167001125 hinge residues; other site 1415167001126 RDD family; Region: RDD; pfam06271 1415167001127 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1415167001128 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1415167001129 beta-galactosidase; Region: BGL; TIGR03356 1415167001130 Competence protein J (ComJ); Region: ComJ; pfam11033 1415167001131 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1415167001132 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167001133 dimerization interface [polypeptide binding]; other site 1415167001134 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1415167001135 dimer interface [polypeptide binding]; other site 1415167001136 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1415167001137 putative CheW interface [polypeptide binding]; other site 1415167001138 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1415167001139 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1415167001140 tetramer interface [polypeptide binding]; other site 1415167001141 active site 1415167001142 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1415167001143 active site 1415167001144 dimer interface [polypeptide binding]; other site 1415167001145 magnesium binding site [ion binding]; other site 1415167001146 Predicted transcriptional regulators [Transcription]; Region: COG1733 1415167001147 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1415167001148 Condensation domain; Region: Condensation; pfam00668 1415167001149 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167001150 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1415167001151 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1415167001152 acyl-activating enzyme (AAE) consensus motif; other site 1415167001153 AMP binding site [chemical binding]; other site 1415167001154 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167001155 Condensation domain; Region: Condensation; pfam00668 1415167001156 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167001157 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1415167001158 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1415167001159 acyl-activating enzyme (AAE) consensus motif; other site 1415167001160 AMP binding site [chemical binding]; other site 1415167001161 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167001162 Condensation domain; Region: Condensation; pfam00668 1415167001163 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167001164 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1415167001165 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1415167001166 acyl-activating enzyme (AAE) consensus motif; other site 1415167001167 AMP binding site [chemical binding]; other site 1415167001168 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167001169 Condensation domain; Region: Condensation; pfam00668 1415167001170 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167001171 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1415167001172 Condensation domain; Region: Condensation; pfam00668 1415167001173 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167001174 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1415167001175 acyl-activating enzyme (AAE) consensus motif; other site 1415167001176 AMP binding site [chemical binding]; other site 1415167001177 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167001178 Condensation domain; Region: Condensation; pfam00668 1415167001179 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167001180 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1415167001181 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1415167001182 acyl-activating enzyme (AAE) consensus motif; other site 1415167001183 AMP binding site [chemical binding]; other site 1415167001184 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167001185 Condensation domain; Region: Condensation; pfam00668 1415167001186 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167001187 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1415167001188 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1415167001189 acyl-activating enzyme (AAE) consensus motif; other site 1415167001190 AMP binding site [chemical binding]; other site 1415167001191 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167001192 Condensation domain; Region: Condensation; pfam00668 1415167001193 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1415167001194 Condensation domain; Region: Condensation; pfam00668 1415167001195 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167001196 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1415167001197 acyl-activating enzyme (AAE) consensus motif; other site 1415167001198 AMP binding site [chemical binding]; other site 1415167001199 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167001200 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1415167001201 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1415167001202 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1415167001203 YcxB-like protein; Region: YcxB; pfam14317 1415167001204 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1415167001205 EamA-like transporter family; Region: EamA; pfam00892 1415167001206 EamA-like transporter family; Region: EamA; pfam00892 1415167001207 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1415167001208 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167001209 DNA-binding site [nucleotide binding]; DNA binding site 1415167001210 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167001211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167001212 homodimer interface [polypeptide binding]; other site 1415167001213 catalytic residue [active] 1415167001214 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1415167001215 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1415167001216 Predicted membrane protein [Function unknown]; Region: COG2364 1415167001217 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167001218 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1415167001219 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1415167001220 Walker A/P-loop; other site 1415167001221 ATP binding site [chemical binding]; other site 1415167001222 Q-loop/lid; other site 1415167001223 ABC transporter signature motif; other site 1415167001224 Walker B; other site 1415167001225 D-loop; other site 1415167001226 H-loop/switch region; other site 1415167001227 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1415167001228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167001229 dimer interface [polypeptide binding]; other site 1415167001230 conserved gate region; other site 1415167001231 putative PBP binding loops; other site 1415167001232 ABC-ATPase subunit interface; other site 1415167001233 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1415167001234 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1415167001235 substrate binding pocket [chemical binding]; other site 1415167001236 membrane-bound complex binding site; other site 1415167001237 hinge residues; other site 1415167001238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167001239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167001240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1415167001241 dimerization interface [polypeptide binding]; other site 1415167001242 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 1415167001243 Flavoprotein; Region: Flavoprotein; pfam02441 1415167001244 UbiD family decarboxylase; Region: TIGR00148 1415167001245 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1415167001246 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1415167001247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001248 putative substrate translocation pore; other site 1415167001249 POT family; Region: PTR2; pfam00854 1415167001250 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1415167001251 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1415167001252 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1415167001253 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1415167001254 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1415167001255 Spore germination protein; Region: Spore_permease; pfam03845 1415167001256 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1415167001257 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1415167001258 Walker A/P-loop; other site 1415167001259 ATP binding site [chemical binding]; other site 1415167001260 Q-loop/lid; other site 1415167001261 ABC transporter signature motif; other site 1415167001262 Walker B; other site 1415167001263 D-loop; other site 1415167001264 H-loop/switch region; other site 1415167001265 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1415167001266 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1415167001267 FtsX-like permease family; Region: FtsX; pfam02687 1415167001268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1415167001269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167001270 active site 1415167001271 phosphorylation site [posttranslational modification] 1415167001272 intermolecular recognition site; other site 1415167001273 dimerization interface [polypeptide binding]; other site 1415167001274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1415167001275 DNA binding site [nucleotide binding] 1415167001276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1415167001277 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167001278 dimerization interface [polypeptide binding]; other site 1415167001279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167001280 dimer interface [polypeptide binding]; other site 1415167001281 phosphorylation site [posttranslational modification] 1415167001282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167001283 ATP binding site [chemical binding]; other site 1415167001284 Mg2+ binding site [ion binding]; other site 1415167001285 G-X-G motif; other site 1415167001286 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1415167001287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167001288 TPR motif; other site 1415167001289 binding surface 1415167001290 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1415167001291 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1415167001292 aspartate kinase; Reviewed; Region: PRK09034 1415167001293 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1415167001294 putative catalytic residues [active] 1415167001295 putative nucleotide binding site [chemical binding]; other site 1415167001296 putative aspartate binding site [chemical binding]; other site 1415167001297 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1415167001298 allosteric regulatory residue; other site 1415167001299 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1415167001300 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1415167001301 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167001302 ABC-ATPase subunit interface; other site 1415167001303 dimer interface [polypeptide binding]; other site 1415167001304 putative PBP binding regions; other site 1415167001305 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167001306 ABC-ATPase subunit interface; other site 1415167001307 dimer interface [polypeptide binding]; other site 1415167001308 putative PBP binding regions; other site 1415167001309 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1415167001310 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1415167001311 Walker A/P-loop; other site 1415167001312 ATP binding site [chemical binding]; other site 1415167001313 Q-loop/lid; other site 1415167001314 ABC transporter signature motif; other site 1415167001315 Walker B; other site 1415167001316 D-loop; other site 1415167001317 H-loop/switch region; other site 1415167001318 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1415167001319 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1415167001320 putative ligand binding residues [chemical binding]; other site 1415167001321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001322 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167001323 putative substrate translocation pore; other site 1415167001324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001325 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1415167001326 dimer interface [polypeptide binding]; other site 1415167001327 FMN binding site [chemical binding]; other site 1415167001328 NADPH bind site [chemical binding]; other site 1415167001329 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1415167001330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167001331 dimerization interface [polypeptide binding]; other site 1415167001332 putative DNA binding site [nucleotide binding]; other site 1415167001333 putative Zn2+ binding site [ion binding]; other site 1415167001334 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1415167001335 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167001336 DNA-binding site [nucleotide binding]; DNA binding site 1415167001337 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167001338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167001339 homodimer interface [polypeptide binding]; other site 1415167001340 catalytic residue [active] 1415167001341 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1415167001342 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1415167001343 inhibitor-cofactor binding pocket; inhibition site 1415167001344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167001345 catalytic residue [active] 1415167001346 succinic semialdehyde dehydrogenase; Region: PLN02278 1415167001347 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1415167001348 tetramerization interface [polypeptide binding]; other site 1415167001349 NAD(P) binding site [chemical binding]; other site 1415167001350 catalytic residues [active] 1415167001351 Sugar transport protein; Region: Sugar_transport; pfam06800 1415167001352 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1415167001353 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1415167001354 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1415167001355 NAD binding site [chemical binding]; other site 1415167001356 homodimer interface [polypeptide binding]; other site 1415167001357 active site 1415167001358 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1415167001359 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1415167001360 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1415167001361 YtkA-like; Region: YtkA; pfam13115 1415167001362 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1415167001363 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1415167001364 NosL; Region: NosL; cl01769 1415167001365 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1415167001366 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1415167001367 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1415167001368 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1415167001369 tartrate dehydrogenase; Provisional; Region: PRK08194 1415167001370 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1415167001371 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1415167001372 Catalytic site [active] 1415167001373 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1415167001374 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1415167001375 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1415167001376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167001377 active site 1415167001378 motif I; other site 1415167001379 motif II; other site 1415167001380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167001381 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1415167001382 putative active site [active] 1415167001383 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1415167001384 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1415167001385 hypothetical protein; Provisional; Region: PRK05463 1415167001386 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1415167001387 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1415167001388 Bacterial transcriptional regulator; Region: IclR; pfam01614 1415167001389 Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755 1415167001390 active site 1415167001391 catalytic triad [active] 1415167001392 oxyanion hole [active] 1415167001393 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1415167001394 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1415167001395 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1415167001396 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1415167001397 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1415167001398 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1415167001399 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1415167001400 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1415167001401 active site 1415167001402 catalytic tetrad [active] 1415167001403 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1415167001404 HTH domain; Region: HTH_11; pfam08279 1415167001405 PRD domain; Region: PRD; pfam00874 1415167001406 PRD domain; Region: PRD; pfam00874 1415167001407 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1415167001408 active site 1415167001409 P-loop; other site 1415167001410 phosphorylation site [posttranslational modification] 1415167001411 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1415167001412 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1415167001413 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1415167001414 acyl-activating enzyme (AAE) consensus motif; other site 1415167001415 putative AMP binding site [chemical binding]; other site 1415167001416 putative active site [active] 1415167001417 putative CoA binding site [chemical binding]; other site 1415167001418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167001419 S-adenosylmethionine binding site [chemical binding]; other site 1415167001420 short chain dehydrogenase; Provisional; Region: PRK06701 1415167001421 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1415167001422 NAD binding site [chemical binding]; other site 1415167001423 metal binding site [ion binding]; metal-binding site 1415167001424 active site 1415167001425 ABC-type sugar transport system, auxiliary component [General function prediction only]; Region: COG3822 1415167001426 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1415167001427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1415167001428 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1415167001429 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1415167001430 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1415167001431 Predicted membrane protein [Function unknown]; Region: COG2261 1415167001432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1415167001433 EcsC protein family; Region: EcsC; pfam12787 1415167001434 General stress protein [General function prediction only]; Region: GsiB; COG3729 1415167001435 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1415167001436 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1415167001437 dimanganese center [ion binding]; other site 1415167001438 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1415167001439 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1415167001440 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1415167001441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167001442 putative active site [active] 1415167001443 heme pocket [chemical binding]; other site 1415167001444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167001445 ATP binding site [chemical binding]; other site 1415167001446 Mg2+ binding site [ion binding]; other site 1415167001447 G-X-G motif; other site 1415167001448 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1415167001449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167001450 active site 1415167001451 phosphorylation site [posttranslational modification] 1415167001452 intermolecular recognition site; other site 1415167001453 dimerization interface [polypeptide binding]; other site 1415167001454 HTH domain; Region: HTH_11; cl17392 1415167001455 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1415167001456 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1415167001457 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1415167001458 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1415167001459 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1415167001460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1415167001461 Walker A/P-loop; other site 1415167001462 ATP binding site [chemical binding]; other site 1415167001463 Q-loop/lid; other site 1415167001464 ABC transporter signature motif; other site 1415167001465 Walker B; other site 1415167001466 D-loop; other site 1415167001467 H-loop/switch region; other site 1415167001468 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1415167001469 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1415167001470 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1415167001471 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1415167001472 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1415167001473 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1415167001474 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1415167001475 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1415167001476 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1415167001477 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1415167001478 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1415167001479 catalytic residues [active] 1415167001480 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1415167001481 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1415167001482 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1415167001483 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1415167001484 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1415167001485 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1415167001486 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1415167001487 helicase 45; Provisional; Region: PTZ00424 1415167001488 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1415167001489 ATP binding site [chemical binding]; other site 1415167001490 Mg++ binding site [ion binding]; other site 1415167001491 motif III; other site 1415167001492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167001493 nucleotide binding region [chemical binding]; other site 1415167001494 ATP-binding site [chemical binding]; other site 1415167001495 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1415167001496 Predicted membrane protein [Function unknown]; Region: COG3428 1415167001497 Bacterial PH domain; Region: DUF304; pfam03703 1415167001498 Bacterial PH domain; Region: DUF304; pfam03703 1415167001499 Bacterial PH domain; Region: DUF304; pfam03703 1415167001500 Rhomboid family; Region: Rhomboid; pfam01694 1415167001501 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 1415167001502 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1415167001503 alanine racemase; Region: alr; TIGR00492 1415167001504 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1415167001505 active site 1415167001506 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1415167001507 dimer interface [polypeptide binding]; other site 1415167001508 substrate binding site [chemical binding]; other site 1415167001509 catalytic residues [active] 1415167001510 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1415167001511 ribbon-helix-helix domain containing protein; Region: PHA00617 1415167001512 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1415167001513 Rsbr N terminal; Region: Rsbr_N; pfam08678 1415167001514 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1415167001515 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1415167001516 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1415167001517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167001518 ATP binding site [chemical binding]; other site 1415167001519 Mg2+ binding site [ion binding]; other site 1415167001520 G-X-G motif; other site 1415167001521 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1415167001522 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1415167001523 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1415167001524 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1415167001525 anti sigma factor interaction site; other site 1415167001526 regulatory phosphorylation site [posttranslational modification]; other site 1415167001527 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1415167001528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167001529 ATP binding site [chemical binding]; other site 1415167001530 Mg2+ binding site [ion binding]; other site 1415167001531 G-X-G motif; other site 1415167001532 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1415167001533 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167001534 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1415167001535 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167001536 DNA binding residues [nucleotide binding] 1415167001537 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1415167001538 hypothetical protein; Provisional; Region: PRK02268 1415167001539 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167001540 MarR family; Region: MarR; pfam01047 1415167001541 MarR family; Region: MarR_2; cl17246 1415167001542 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1415167001543 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1415167001544 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1415167001545 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1415167001546 RNA binding site [nucleotide binding]; other site 1415167001547 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1415167001548 hypothetical protein; Provisional; Region: PRK04351 1415167001549 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1415167001550 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1415167001551 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1415167001552 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1415167001553 AsnC family; Region: AsnC_trans_reg; pfam01037 1415167001554 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1415167001555 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1415167001556 putative DNA binding site [nucleotide binding]; other site 1415167001557 putative Zn2+ binding site [ion binding]; other site 1415167001558 AsnC family; Region: AsnC_trans_reg; pfam01037 1415167001559 Isochorismatase family; Region: Isochorismatase; pfam00857 1415167001560 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1415167001561 catalytic triad [active] 1415167001562 conserved cis-peptide bond; other site 1415167001563 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1415167001564 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1415167001565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001566 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167001567 putative substrate translocation pore; other site 1415167001568 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1415167001569 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1415167001570 conserved cys residue [active] 1415167001571 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1415167001572 DNA-binding site [nucleotide binding]; DNA binding site 1415167001573 RNA-binding motif; other site 1415167001574 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1415167001575 EamA-like transporter family; Region: EamA; cl17759 1415167001576 Cupin domain; Region: Cupin_2; pfam07883 1415167001577 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1415167001578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167001579 EamA-like transporter family; Region: EamA; pfam00892 1415167001580 EamA-like transporter family; Region: EamA; pfam00892 1415167001581 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1415167001582 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167001583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1415167001584 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1415167001585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167001586 DNA-binding site [nucleotide binding]; DNA binding site 1415167001587 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167001588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167001589 homodimer interface [polypeptide binding]; other site 1415167001590 catalytic residue [active] 1415167001591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001592 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167001593 putative substrate translocation pore; other site 1415167001594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1415167001595 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1415167001596 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1415167001597 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1415167001598 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1415167001599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167001600 DNA-binding site [nucleotide binding]; DNA binding site 1415167001601 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167001602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167001603 homodimer interface [polypeptide binding]; other site 1415167001604 catalytic residue [active] 1415167001605 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1415167001606 putative active site [active] 1415167001607 putative catalytic site [active] 1415167001608 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1415167001609 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1415167001610 Predicted transcriptional regulators [Transcription]; Region: COG1733 1415167001611 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1415167001612 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1415167001613 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167001614 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167001615 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1415167001616 Predicted transcriptional regulators [Transcription]; Region: COG1733 1415167001617 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1415167001618 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1415167001619 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1415167001620 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1415167001621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001622 putative substrate translocation pore; other site 1415167001623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167001624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167001625 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167001626 dimerization interface [polypeptide binding]; other site 1415167001627 putative DNA binding site [nucleotide binding]; other site 1415167001628 putative Zn2+ binding site [ion binding]; other site 1415167001629 arsenical pump membrane protein; Provisional; Region: PRK15445 1415167001630 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1415167001631 transmembrane helices; other site 1415167001632 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1415167001633 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1415167001634 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1415167001635 EamA-like transporter family; Region: EamA; pfam00892 1415167001636 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1415167001637 EamA-like transporter family; Region: EamA; pfam00892 1415167001638 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1415167001639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167001640 DNA-binding site [nucleotide binding]; DNA binding site 1415167001641 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167001642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167001643 homodimer interface [polypeptide binding]; other site 1415167001644 catalytic residue [active] 1415167001645 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1415167001646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167001647 putative DNA binding site [nucleotide binding]; other site 1415167001648 putative Zn2+ binding site [ion binding]; other site 1415167001649 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1415167001650 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1415167001651 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1415167001652 Histidine kinase; Region: HisKA_3; pfam07730 1415167001653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167001654 ATP binding site [chemical binding]; other site 1415167001655 Mg2+ binding site [ion binding]; other site 1415167001656 G-X-G motif; other site 1415167001657 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1415167001658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167001659 active site 1415167001660 phosphorylation site [posttranslational modification] 1415167001661 intermolecular recognition site; other site 1415167001662 dimerization interface [polypeptide binding]; other site 1415167001663 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1415167001664 DNA binding residues [nucleotide binding] 1415167001665 dimerization interface [polypeptide binding]; other site 1415167001666 MMPL family; Region: MMPL; pfam03176 1415167001667 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1415167001668 MMPL family; Region: MMPL; pfam03176 1415167001669 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1415167001670 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1415167001671 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1415167001672 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1415167001673 DNA binding residues [nucleotide binding] 1415167001674 drug binding residues [chemical binding]; other site 1415167001675 dimer interface [polypeptide binding]; other site 1415167001676 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1415167001677 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1415167001678 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1415167001679 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1415167001680 dimer interface [polypeptide binding]; other site 1415167001681 FMN binding site [chemical binding]; other site 1415167001682 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1415167001683 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167001684 Zn binding site [ion binding]; other site 1415167001685 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1415167001686 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167001687 Zn binding site [ion binding]; other site 1415167001688 Predicted membrane protein [Function unknown]; Region: COG2259 1415167001689 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1415167001690 catalytic residues [active] 1415167001691 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1415167001692 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1415167001693 Predicted membrane protein [Function unknown]; Region: COG2323 1415167001694 Predicted membrane protein [Function unknown]; Region: COG2323 1415167001695 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1415167001696 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1415167001697 putative dimer interface [polypeptide binding]; other site 1415167001698 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1415167001699 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1415167001700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167001701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167001702 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1415167001703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167001704 Coenzyme A binding pocket [chemical binding]; other site 1415167001705 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1415167001706 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1415167001707 ABC transporter; Region: ABC_tran_2; pfam12848 1415167001708 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1415167001709 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1415167001710 DinB family; Region: DinB; pfam05163 1415167001711 DinB superfamily; Region: DinB_2; pfam12867 1415167001712 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167001713 MarR family; Region: MarR; pfam01047 1415167001714 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1415167001715 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1415167001716 dimer interface [polypeptide binding]; other site 1415167001717 FMN binding site [chemical binding]; other site 1415167001718 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167001719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167001720 putative DNA binding site [nucleotide binding]; other site 1415167001721 putative Zn2+ binding site [ion binding]; other site 1415167001722 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1415167001723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001724 putative substrate translocation pore; other site 1415167001725 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1415167001726 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1415167001727 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167001728 DNA-binding site [nucleotide binding]; DNA binding site 1415167001729 FCD domain; Region: FCD; pfam07729 1415167001730 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1415167001731 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167001732 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167001733 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1415167001734 active site 1415167001735 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1415167001736 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1415167001737 homodimer interface [polypeptide binding]; other site 1415167001738 active site 1415167001739 TDP-binding site; other site 1415167001740 acceptor substrate-binding pocket; other site 1415167001741 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1415167001742 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1415167001743 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1415167001744 dimer interface [polypeptide binding]; other site 1415167001745 active site 1415167001746 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1415167001747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167001748 Coenzyme A binding pocket [chemical binding]; other site 1415167001749 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1415167001750 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1415167001751 Zn2+ binding site [ion binding]; other site 1415167001752 Mg2+ binding site [ion binding]; other site 1415167001753 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1415167001754 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1415167001755 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1415167001756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001757 putative substrate translocation pore; other site 1415167001758 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1415167001759 active site 1415167001760 P-loop; other site 1415167001761 phosphorylation site [posttranslational modification] 1415167001762 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1415167001763 active site 1415167001764 methionine cluster; other site 1415167001765 phosphorylation site [posttranslational modification] 1415167001766 metal binding site [ion binding]; metal-binding site 1415167001767 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1415167001768 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1415167001769 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1415167001770 beta-galactosidase; Region: BGL; TIGR03356 1415167001771 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1415167001772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167001773 DNA-binding site [nucleotide binding]; DNA binding site 1415167001774 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1415167001775 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1415167001776 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1415167001777 nucleotide binding site [chemical binding]; other site 1415167001778 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1415167001779 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1415167001780 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1415167001781 thiamine-monophosphate kinase; Region: thiL; TIGR01379 1415167001782 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1415167001783 ATP binding site [chemical binding]; other site 1415167001784 dimerization interface [polypeptide binding]; other site 1415167001785 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1415167001786 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1415167001787 Glycoprotease family; Region: Peptidase_M22; pfam00814 1415167001788 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1415167001789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167001790 Coenzyme A binding pocket [chemical binding]; other site 1415167001791 UGMP family protein; Validated; Region: PRK09604 1415167001792 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1415167001793 nucleotide binding site [chemical binding]; other site 1415167001794 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1415167001795 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1415167001796 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1415167001797 ABC transporter; Region: ABC_tran_2; pfam12848 1415167001798 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1415167001799 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1415167001800 trimer interface [polypeptide binding]; other site 1415167001801 dimer interface [polypeptide binding]; other site 1415167001802 putative active site [active] 1415167001803 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1415167001804 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1415167001805 CoA binding domain; Region: CoA_binding; pfam02629 1415167001806 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1415167001807 Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945 1415167001808 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1415167001809 CAAX protease self-immunity; Region: Abi; pfam02517 1415167001810 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1415167001811 oligomerisation interface [polypeptide binding]; other site 1415167001812 mobile loop; other site 1415167001813 roof hairpin; other site 1415167001814 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1415167001815 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1415167001816 ring oligomerisation interface [polypeptide binding]; other site 1415167001817 ATP/Mg binding site [chemical binding]; other site 1415167001818 stacking interactions; other site 1415167001819 hinge regions; other site 1415167001820 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1415167001821 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1415167001822 cofactor binding site; other site 1415167001823 DNA binding site [nucleotide binding] 1415167001824 substrate interaction site [chemical binding]; other site 1415167001825 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1415167001826 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1415167001827 cofactor binding site; other site 1415167001828 DNA binding site [nucleotide binding] 1415167001829 substrate interaction site [chemical binding]; other site 1415167001830 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 1415167001831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1415167001832 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 1415167001833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1415167001834 Walker A motif; other site 1415167001835 ATP binding site [chemical binding]; other site 1415167001836 Walker B motif; other site 1415167001837 TPR repeat; Region: TPR_11; pfam13414 1415167001838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167001839 TPR motif; other site 1415167001840 TPR repeat; Region: TPR_11; pfam13414 1415167001841 binding surface 1415167001842 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1415167001843 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1415167001844 inhibitor binding site; inhibition site 1415167001845 catalytic Zn binding site [ion binding]; other site 1415167001846 structural Zn binding site [ion binding]; other site 1415167001847 NADP binding site [chemical binding]; other site 1415167001848 tetramer interface [polypeptide binding]; other site 1415167001849 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1415167001850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001851 putative substrate translocation pore; other site 1415167001852 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1415167001853 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1415167001854 putative substrate binding site [chemical binding]; other site 1415167001855 putative ATP binding site [chemical binding]; other site 1415167001856 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1415167001857 DNA-directed RNA polymerase subunit F; Provisional; Region: PRK14981 1415167001858 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1415167001859 Repair protein; Region: Repair_PSII; pfam04536 1415167001860 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1415167001861 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1415167001862 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1415167001863 Double zinc ribbon; Region: DZR; pfam12773 1415167001864 Ion channel; Region: Ion_trans_2; pfam07885 1415167001865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001866 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1415167001867 putative substrate translocation pore; other site 1415167001868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167001869 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1415167001870 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1415167001871 putative NAD(P) binding site [chemical binding]; other site 1415167001872 catalytic Zn binding site [ion binding]; other site 1415167001873 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1415167001874 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1415167001875 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1415167001876 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1415167001877 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1415167001878 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1415167001879 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1415167001880 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1415167001881 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1415167001882 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1415167001883 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1415167001884 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1415167001885 MoxR-like ATPases [General function prediction only]; Region: COG0714 1415167001886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167001887 Walker A motif; other site 1415167001888 ATP binding site [chemical binding]; other site 1415167001889 Walker B motif; other site 1415167001890 arginine finger; other site 1415167001891 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1415167001892 Protein of unknown function DUF58; Region: DUF58; pfam01882 1415167001893 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1415167001894 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1415167001895 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1415167001896 GMP synthase; Reviewed; Region: guaA; PRK00074 1415167001897 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1415167001898 AMP/PPi binding site [chemical binding]; other site 1415167001899 candidate oxyanion hole; other site 1415167001900 catalytic triad [active] 1415167001901 potential glutamine specificity residues [chemical binding]; other site 1415167001902 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1415167001903 ATP Binding subdomain [chemical binding]; other site 1415167001904 Ligand Binding sites [chemical binding]; other site 1415167001905 Dimerization subdomain; other site 1415167001906 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1415167001907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1415167001908 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1415167001909 NETI protein; Region: NETI; pfam14044 1415167001910 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1415167001911 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1415167001912 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1415167001913 NAD binding site [chemical binding]; other site 1415167001914 ATP-grasp domain; Region: ATP-grasp; pfam02222 1415167001915 adenylosuccinate lyase; Provisional; Region: PRK07492 1415167001916 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1415167001917 tetramer interface [polypeptide binding]; other site 1415167001918 active site 1415167001919 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1415167001920 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1415167001921 ATP binding site [chemical binding]; other site 1415167001922 active site 1415167001923 substrate binding site [chemical binding]; other site 1415167001924 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1415167001925 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1415167001926 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1415167001927 putative active site [active] 1415167001928 catalytic triad [active] 1415167001929 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1415167001930 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1415167001931 dimerization interface [polypeptide binding]; other site 1415167001932 ATP binding site [chemical binding]; other site 1415167001933 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1415167001934 dimerization interface [polypeptide binding]; other site 1415167001935 ATP binding site [chemical binding]; other site 1415167001936 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1415167001937 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1415167001938 active site 1415167001939 tetramer interface [polypeptide binding]; other site 1415167001940 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1415167001941 active site 1415167001942 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1415167001943 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1415167001944 dimerization interface [polypeptide binding]; other site 1415167001945 putative ATP binding site [chemical binding]; other site 1415167001946 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1415167001947 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1415167001948 active site 1415167001949 substrate binding site [chemical binding]; other site 1415167001950 cosubstrate binding site; other site 1415167001951 catalytic site [active] 1415167001952 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1415167001953 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1415167001954 purine monophosphate binding site [chemical binding]; other site 1415167001955 dimer interface [polypeptide binding]; other site 1415167001956 putative catalytic residues [active] 1415167001957 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1415167001958 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1415167001959 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1415167001960 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1415167001961 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1415167001962 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1415167001963 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1415167001964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167001965 putative DNA binding site [nucleotide binding]; other site 1415167001966 putative Zn2+ binding site [ion binding]; other site 1415167001967 AsnC family; Region: AsnC_trans_reg; pfam01037 1415167001968 putative transporter; Provisional; Region: PRK11021 1415167001969 Spore germination protein; Region: Spore_permease; cl17796 1415167001970 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1415167001971 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1415167001972 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1415167001973 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1415167001974 active site 1415167001975 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1415167001976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1415167001977 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1415167001978 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1415167001979 active site 1415167001980 FMN binding site [chemical binding]; other site 1415167001981 substrate binding site [chemical binding]; other site 1415167001982 3Fe-4S cluster binding site [ion binding]; other site 1415167001983 PcrB family; Region: PcrB; pfam01884 1415167001984 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1415167001985 substrate binding site [chemical binding]; other site 1415167001986 putative active site [active] 1415167001987 dimer interface [polypeptide binding]; other site 1415167001988 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1415167001989 Part of AAA domain; Region: AAA_19; pfam13245 1415167001990 Family description; Region: UvrD_C_2; pfam13538 1415167001991 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1415167001992 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1415167001993 nucleotide binding pocket [chemical binding]; other site 1415167001994 K-X-D-G motif; other site 1415167001995 catalytic site [active] 1415167001996 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1415167001997 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1415167001998 Helix-hairpin-helix motif; Region: HHH; pfam00633 1415167001999 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1415167002000 Dimer interface [polypeptide binding]; other site 1415167002001 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1415167002002 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1415167002003 putative dimer interface [polypeptide binding]; other site 1415167002004 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1415167002005 putative dimer interface [polypeptide binding]; other site 1415167002006 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1415167002007 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1415167002008 active site 1415167002009 ATP binding site [chemical binding]; other site 1415167002010 substrate binding site [chemical binding]; other site 1415167002011 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1415167002012 MgtC family; Region: MgtC; pfam02308 1415167002013 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1415167002014 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1415167002015 Na binding site [ion binding]; other site 1415167002016 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1415167002017 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1415167002018 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1415167002019 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1415167002020 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1415167002021 GatB domain; Region: GatB_Yqey; pfam02637 1415167002022 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167002023 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167002024 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1415167002025 Protein export membrane protein; Region: SecD_SecF; cl14618 1415167002026 Protein export membrane protein; Region: SecD_SecF; cl14618 1415167002027 putative lipid kinase; Reviewed; Region: PRK13337 1415167002028 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1415167002029 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1415167002030 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1415167002031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167002032 S-adenosylmethionine binding site [chemical binding]; other site 1415167002033 Recombinase; Region: Recombinase; pfam07508 1415167002034 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1415167002035 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1415167002036 DNA-binding interface [nucleotide binding]; DNA binding site 1415167002037 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1415167002038 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1415167002039 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1415167002040 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1415167002041 ATP binding site [chemical binding]; other site 1415167002042 putative Mg++ binding site [ion binding]; other site 1415167002043 T5orf172 domain; Region: T5orf172; pfam10544 1415167002044 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1415167002045 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1415167002046 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1415167002047 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1415167002048 hypothetical protein; Provisional; Region: PRK12378 1415167002049 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1415167002050 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1415167002051 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1415167002052 NADP binding site [chemical binding]; other site 1415167002053 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1415167002054 CotJB protein; Region: CotJB; pfam12652 1415167002055 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1415167002056 dimanganese center [ion binding]; other site 1415167002057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167002058 Coenzyme A binding pocket [chemical binding]; other site 1415167002059 YesK-like protein; Region: YesK; pfam14150 1415167002060 Predicted integral membrane protein [Function unknown]; Region: COG5578 1415167002061 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1415167002062 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1415167002063 dimerization interface [polypeptide binding]; other site 1415167002064 Histidine kinase; Region: His_kinase; pfam06580 1415167002065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167002066 ATP binding site [chemical binding]; other site 1415167002067 Mg2+ binding site [ion binding]; other site 1415167002068 G-X-G motif; other site 1415167002069 Response regulator receiver domain; Region: Response_reg; pfam00072 1415167002070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167002071 active site 1415167002072 phosphorylation site [posttranslational modification] 1415167002073 intermolecular recognition site; other site 1415167002074 dimerization interface [polypeptide binding]; other site 1415167002075 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1415167002076 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167002077 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1415167002078 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1415167002079 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1415167002080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167002081 dimer interface [polypeptide binding]; other site 1415167002082 conserved gate region; other site 1415167002083 putative PBP binding loops; other site 1415167002084 ABC-ATPase subunit interface; other site 1415167002085 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1415167002086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167002087 dimer interface [polypeptide binding]; other site 1415167002088 conserved gate region; other site 1415167002089 putative PBP binding loops; other site 1415167002090 ABC-ATPase subunit interface; other site 1415167002091 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1415167002092 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1415167002093 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167002094 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1415167002095 active site 1415167002096 catalytic triad [active] 1415167002097 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 1415167002098 Predicted integral membrane protein [Function unknown]; Region: COG5578 1415167002099 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1415167002100 metal binding site [ion binding]; metal-binding site 1415167002101 active site 1415167002102 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1415167002103 metal binding site [ion binding]; metal-binding site 1415167002104 active site 1415167002105 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1415167002106 active site 1415167002107 catalytic triad [active] 1415167002108 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1415167002109 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1415167002110 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1415167002111 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1415167002112 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1415167002113 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1415167002114 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1415167002115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167002116 dimer interface [polypeptide binding]; other site 1415167002117 putative PBP binding loops; other site 1415167002118 ABC-ATPase subunit interface; other site 1415167002119 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1415167002120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167002121 dimer interface [polypeptide binding]; other site 1415167002122 conserved gate region; other site 1415167002123 putative PBP binding loops; other site 1415167002124 ABC-ATPase subunit interface; other site 1415167002125 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1415167002126 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1415167002127 NAD binding site [chemical binding]; other site 1415167002128 sugar binding site [chemical binding]; other site 1415167002129 divalent metal binding site [ion binding]; other site 1415167002130 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1415167002131 dimer interface [polypeptide binding]; other site 1415167002132 Predicted membrane protein [Function unknown]; Region: COG2323 1415167002133 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1415167002134 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167002135 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1415167002136 Uncharacterized small protein [Function unknown]; Region: COG5583 1415167002137 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1415167002138 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1415167002139 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1415167002140 EamA-like transporter family; Region: EamA; pfam00892 1415167002141 EamA-like transporter family; Region: EamA; pfam00892 1415167002142 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167002143 MarR family; Region: MarR; pfam01047 1415167002144 hypothetical protein; Provisional; Region: PRK06847 1415167002145 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1415167002146 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1415167002147 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1415167002148 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1415167002149 Cytochrome P450; Region: p450; pfam00067 1415167002150 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1415167002151 Flavodoxin; Region: Flavodoxin_1; pfam00258 1415167002152 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1415167002153 FAD binding pocket [chemical binding]; other site 1415167002154 FAD binding motif [chemical binding]; other site 1415167002155 catalytic residues [active] 1415167002156 NAD binding pocket [chemical binding]; other site 1415167002157 phosphate binding motif [ion binding]; other site 1415167002158 beta-alpha-beta structure motif; other site 1415167002159 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1415167002160 Sulfatase; Region: Sulfatase; pfam00884 1415167002161 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1415167002162 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1415167002163 substrate binding site; other site 1415167002164 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1415167002165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1415167002166 NAD(P) binding site [chemical binding]; other site 1415167002167 active site 1415167002168 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 1415167002169 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1415167002170 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1415167002171 active site 1415167002172 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1415167002173 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 1415167002174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167002175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167002176 putative substrate translocation pore; other site 1415167002177 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1415167002178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167002179 active site 1415167002180 motif I; other site 1415167002181 motif II; other site 1415167002182 amino acid transporter; Region: 2A0306; TIGR00909 1415167002183 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1415167002184 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1415167002185 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1415167002186 NAD(P) binding site [chemical binding]; other site 1415167002187 catalytic residues [active] 1415167002188 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1415167002189 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1415167002190 dimer interface [polypeptide binding]; other site 1415167002191 putative CheW interface [polypeptide binding]; other site 1415167002192 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1415167002193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1415167002194 Walker A/P-loop; other site 1415167002195 ATP binding site [chemical binding]; other site 1415167002196 Q-loop/lid; other site 1415167002197 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1415167002198 ABC transporter signature motif; other site 1415167002199 Walker B; other site 1415167002200 D-loop; other site 1415167002201 ABC transporter; Region: ABC_tran_2; pfam12848 1415167002202 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1415167002203 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1415167002204 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1415167002205 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1415167002206 DNA binding residues [nucleotide binding] 1415167002207 putative dimer interface [polypeptide binding]; other site 1415167002208 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1415167002209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167002210 putative substrate translocation pore; other site 1415167002211 Dehydratase family; Region: ILVD_EDD; cl00340 1415167002212 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1415167002213 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1415167002214 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1415167002215 ABC transporter; Region: ABC_tran_2; pfam12848 1415167002216 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1415167002217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1415167002218 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1415167002219 ATP binding site [chemical binding]; other site 1415167002220 putative Mg++ binding site [ion binding]; other site 1415167002221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167002222 nucleotide binding region [chemical binding]; other site 1415167002223 ATP-binding site [chemical binding]; other site 1415167002224 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1415167002225 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1415167002226 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1415167002227 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1415167002228 NAD(P) binding site [chemical binding]; other site 1415167002229 substrate binding site [chemical binding]; other site 1415167002230 dimer interface [polypeptide binding]; other site 1415167002231 H+ Antiporter protein; Region: 2A0121; TIGR00900 1415167002232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167002233 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1415167002234 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1415167002235 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1415167002236 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1415167002237 Walker A/P-loop; other site 1415167002238 ATP binding site [chemical binding]; other site 1415167002239 Q-loop/lid; other site 1415167002240 ABC transporter signature motif; other site 1415167002241 Walker B; other site 1415167002242 D-loop; other site 1415167002243 H-loop/switch region; other site 1415167002244 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1415167002245 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167002246 ABC-ATPase subunit interface; other site 1415167002247 dimer interface [polypeptide binding]; other site 1415167002248 putative PBP binding regions; other site 1415167002249 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1415167002250 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167002251 ABC-ATPase subunit interface; other site 1415167002252 dimer interface [polypeptide binding]; other site 1415167002253 putative PBP binding regions; other site 1415167002254 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1415167002255 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1415167002256 siderophore binding site; other site 1415167002257 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1415167002258 Heat induced stress protein YflT; Region: YflT; pfam11181 1415167002259 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1415167002260 Amb_all domain; Region: Amb_all; smart00656 1415167002261 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1415167002262 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1415167002263 transmembrane helices; other site 1415167002264 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1415167002265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167002266 ATP binding site [chemical binding]; other site 1415167002267 Mg2+ binding site [ion binding]; other site 1415167002268 G-X-G motif; other site 1415167002269 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1415167002270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167002271 active site 1415167002272 phosphorylation site [posttranslational modification] 1415167002273 intermolecular recognition site; other site 1415167002274 dimerization interface [polypeptide binding]; other site 1415167002275 Transcriptional regulator; Region: CitT; pfam12431 1415167002276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1415167002277 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1415167002278 Citrate transporter; Region: CitMHS; pfam03600 1415167002279 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1415167002280 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1415167002281 active site 1415167002282 dimer interface [polypeptide binding]; other site 1415167002283 acylphosphatase; Provisional; Region: PRK14420 1415167002284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1415167002285 MOSC domain; Region: MOSC; pfam03473 1415167002286 3-alpha domain; Region: 3-alpha; pfam03475 1415167002287 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1415167002288 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1415167002289 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1415167002290 active site 1415167002291 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1415167002292 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1415167002293 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1415167002294 active site turn [active] 1415167002295 phosphorylation site [posttranslational modification] 1415167002296 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1415167002297 Sulfatase; Region: Sulfatase; pfam00884 1415167002298 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1415167002299 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1415167002300 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1415167002301 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 1415167002302 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1415167002303 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1415167002304 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1415167002305 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1415167002306 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1415167002307 active site turn [active] 1415167002308 phosphorylation site [posttranslational modification] 1415167002309 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1415167002310 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1415167002311 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1415167002312 Ca binding site [ion binding]; other site 1415167002313 active site 1415167002314 catalytic site [active] 1415167002315 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1415167002316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167002317 DNA-binding site [nucleotide binding]; DNA binding site 1415167002318 UTRA domain; Region: UTRA; pfam07702 1415167002319 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1415167002320 dimer interface [polypeptide binding]; other site 1415167002321 FMN binding site [chemical binding]; other site 1415167002322 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1415167002323 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1415167002324 active site 1415167002325 metal binding site [ion binding]; metal-binding site 1415167002326 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1415167002327 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 1415167002328 active site 1415167002329 metal binding site [ion binding]; metal-binding site 1415167002330 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1415167002331 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1415167002332 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1415167002333 proposed catalytic triad [active] 1415167002334 conserved cys residue [active] 1415167002335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167002336 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167002337 putative substrate translocation pore; other site 1415167002338 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1415167002339 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1415167002340 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1415167002341 active site 1415167002342 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 1415167002343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167002344 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167002345 putative substrate translocation pore; other site 1415167002346 calcium/proton exchanger (cax); Region: cax; TIGR00378 1415167002347 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1415167002348 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1415167002349 YfkD-like protein; Region: YfkD; pfam14167 1415167002350 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1415167002351 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1415167002352 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1415167002353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167002354 FeS/SAM binding site; other site 1415167002355 YfkB-like domain; Region: YfkB; pfam08756 1415167002356 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1415167002357 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1415167002358 NodB motif; other site 1415167002359 active site 1415167002360 catalytic site [active] 1415167002361 Cd binding site [ion binding]; other site 1415167002362 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1415167002363 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1415167002364 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1415167002365 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1415167002366 oligomer interface [polypeptide binding]; other site 1415167002367 metal binding site [ion binding]; metal-binding site 1415167002368 metal binding site [ion binding]; metal-binding site 1415167002369 putative Cl binding site [ion binding]; other site 1415167002370 aspartate ring; other site 1415167002371 basic sphincter; other site 1415167002372 hydrophobic gate; other site 1415167002373 periplasmic entrance; other site 1415167002374 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1415167002375 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1415167002376 minor groove reading motif; other site 1415167002377 helix-hairpin-helix signature motif; other site 1415167002378 substrate binding pocket [chemical binding]; other site 1415167002379 active site 1415167002380 TRAM domain; Region: TRAM; pfam01938 1415167002381 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1415167002382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167002383 S-adenosylmethionine binding site [chemical binding]; other site 1415167002384 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1415167002385 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1415167002386 FMN binding site [chemical binding]; other site 1415167002387 active site 1415167002388 catalytic residues [active] 1415167002389 substrate binding site [chemical binding]; other site 1415167002390 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 1415167002391 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1415167002392 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1415167002393 tetramer interface [polypeptide binding]; other site 1415167002394 TPP-binding site [chemical binding]; other site 1415167002395 heterodimer interface [polypeptide binding]; other site 1415167002396 phosphorylation loop region [posttranslational modification] 1415167002397 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1415167002398 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1415167002399 alpha subunit interface [polypeptide binding]; other site 1415167002400 TPP binding site [chemical binding]; other site 1415167002401 heterodimer interface [polypeptide binding]; other site 1415167002402 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1415167002403 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1415167002404 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1415167002405 E3 interaction surface; other site 1415167002406 lipoyl attachment site [posttranslational modification]; other site 1415167002407 e3 binding domain; Region: E3_binding; pfam02817 1415167002408 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1415167002409 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1415167002410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1415167002411 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1415167002412 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1415167002413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167002414 Walker A motif; other site 1415167002415 ATP binding site [chemical binding]; other site 1415167002416 Walker B motif; other site 1415167002417 arginine finger; other site 1415167002418 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1415167002419 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 1415167002420 hypothetical protein; Provisional; Region: PRK02237 1415167002421 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1415167002422 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1415167002423 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1415167002424 NAD binding site [chemical binding]; other site 1415167002425 sugar binding site [chemical binding]; other site 1415167002426 divalent metal binding site [ion binding]; other site 1415167002427 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1415167002428 dimer interface [polypeptide binding]; other site 1415167002429 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1415167002430 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1415167002431 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1415167002432 putative active site [active] 1415167002433 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1415167002434 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1415167002435 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1415167002436 active site turn [active] 1415167002437 phosphorylation site [posttranslational modification] 1415167002438 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1415167002439 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1415167002440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1415167002441 Walker A/P-loop; other site 1415167002442 ATP binding site [chemical binding]; other site 1415167002443 Q-loop/lid; other site 1415167002444 ABC transporter signature motif; other site 1415167002445 Walker B; other site 1415167002446 D-loop; other site 1415167002447 H-loop/switch region; other site 1415167002448 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1415167002449 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1415167002450 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1415167002451 Walker A/P-loop; other site 1415167002452 ATP binding site [chemical binding]; other site 1415167002453 Q-loop/lid; other site 1415167002454 ABC transporter signature motif; other site 1415167002455 Walker B; other site 1415167002456 D-loop; other site 1415167002457 H-loop/switch region; other site 1415167002458 Predicted membrane protein [Function unknown]; Region: COG2259 1415167002459 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1415167002460 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1415167002461 putative metal binding site [ion binding]; other site 1415167002462 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1415167002463 active site 1415167002464 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1415167002465 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1415167002466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167002467 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167002468 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1415167002469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167002470 putative substrate translocation pore; other site 1415167002471 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1415167002472 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1415167002473 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1415167002474 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1415167002475 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1415167002476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1415167002477 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1415167002478 Histidine kinase; Region: HisKA_3; pfam07730 1415167002479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167002480 ATP binding site [chemical binding]; other site 1415167002481 Mg2+ binding site [ion binding]; other site 1415167002482 G-X-G motif; other site 1415167002483 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1415167002484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167002485 active site 1415167002486 phosphorylation site [posttranslational modification] 1415167002487 intermolecular recognition site; other site 1415167002488 dimerization interface [polypeptide binding]; other site 1415167002489 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1415167002490 DNA binding residues [nucleotide binding] 1415167002491 dimerization interface [polypeptide binding]; other site 1415167002492 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1415167002493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1415167002494 Walker A/P-loop; other site 1415167002495 ATP binding site [chemical binding]; other site 1415167002496 Q-loop/lid; other site 1415167002497 ABC transporter signature motif; other site 1415167002498 Walker B; other site 1415167002499 D-loop; other site 1415167002500 H-loop/switch region; other site 1415167002501 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1415167002502 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1415167002503 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1415167002504 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1415167002505 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1415167002506 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1415167002507 Predicted transcriptional regulators [Transcription]; Region: COG1695 1415167002508 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1415167002509 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1415167002510 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1415167002511 Lipase (class 2); Region: Lipase_2; pfam01674 1415167002512 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1415167002513 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1415167002514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167002515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167002516 H+ Antiporter protein; Region: 2A0121; TIGR00900 1415167002517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167002518 putative substrate translocation pore; other site 1415167002519 metal-dependent hydrolase; Provisional; Region: PRK13291 1415167002520 DinB superfamily; Region: DinB_2; pfam12867 1415167002521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167002522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167002523 putative substrate translocation pore; other site 1415167002524 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167002525 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167002526 putative Zn2+ binding site [ion binding]; other site 1415167002527 putative DNA binding site [nucleotide binding]; other site 1415167002528 Predicted integral membrane protein [Function unknown]; Region: COG0392 1415167002529 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1415167002530 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1415167002531 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1415167002532 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1415167002533 siderophore binding site; other site 1415167002534 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1415167002535 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167002536 ABC-ATPase subunit interface; other site 1415167002537 dimer interface [polypeptide binding]; other site 1415167002538 putative PBP binding regions; other site 1415167002539 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1415167002540 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167002541 ABC-ATPase subunit interface; other site 1415167002542 dimer interface [polypeptide binding]; other site 1415167002543 putative PBP binding regions; other site 1415167002544 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1415167002545 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1415167002546 putative FMN binding site [chemical binding]; other site 1415167002547 YfhD-like protein; Region: YfhD; pfam14151 1415167002548 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1415167002549 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1415167002550 putative NAD(P) binding site [chemical binding]; other site 1415167002551 putative active site [active] 1415167002552 recombination regulator RecX; Provisional; Region: recX; PRK14135 1415167002553 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1415167002554 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1415167002555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167002556 putative substrate translocation pore; other site 1415167002557 Small acid-soluble spore protein K family; Region: SspK; pfam08176 1415167002558 WVELL protein; Region: WVELL; pfam14043 1415167002559 Bacterial SH3 domain; Region: SH3_3; pfam08239 1415167002560 Bacterial SH3 domain; Region: SH3_3; cl17532 1415167002561 Predicted integral membrane protein [Function unknown]; Region: COG5658 1415167002562 SdpI/YhfL protein family; Region: SdpI; pfam13630 1415167002563 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1415167002564 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1415167002565 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1415167002566 catalytic site [active] 1415167002567 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1415167002568 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1415167002569 Ligand binding site; other site 1415167002570 Putative Catalytic site; other site 1415167002571 DXD motif; other site 1415167002572 Predicted membrane protein [Function unknown]; Region: COG4485 1415167002573 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1415167002574 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1415167002575 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1415167002576 minor groove reading motif; other site 1415167002577 helix-hairpin-helix signature motif; other site 1415167002578 substrate binding pocket [chemical binding]; other site 1415167002579 active site 1415167002580 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1415167002581 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1415167002582 DNA binding and oxoG recognition site [nucleotide binding] 1415167002583 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1415167002584 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1415167002585 putative NAD(P) binding site [chemical binding]; other site 1415167002586 active site 1415167002587 YgaB-like protein; Region: YgaB; pfam14182 1415167002588 hypothetical protein; Provisional; Region: PRK13662 1415167002589 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1415167002590 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1415167002591 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1415167002592 Walker A/P-loop; other site 1415167002593 ATP binding site [chemical binding]; other site 1415167002594 Q-loop/lid; other site 1415167002595 ABC transporter signature motif; other site 1415167002596 Walker B; other site 1415167002597 D-loop; other site 1415167002598 H-loop/switch region; other site 1415167002599 Predicted membrane protein [Function unknown]; Region: COG4129 1415167002600 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1415167002601 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1415167002602 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1415167002603 inhibitor-cofactor binding pocket; inhibition site 1415167002604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167002605 catalytic residue [active] 1415167002606 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1415167002607 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1415167002608 catalytic triad [active] 1415167002609 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1415167002610 metal binding site 2 [ion binding]; metal-binding site 1415167002611 putative DNA binding helix; other site 1415167002612 metal binding site 1 [ion binding]; metal-binding site 1415167002613 dimer interface [polypeptide binding]; other site 1415167002614 structural Zn2+ binding site [ion binding]; other site 1415167002615 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1415167002616 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1415167002617 SpoOM protein; Region: Spo0M; pfam07070 1415167002618 Coat F domain; Region: Coat_F; cl17715 1415167002619 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1415167002620 ThiC-associated domain; Region: ThiC-associated; pfam13667 1415167002621 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1415167002622 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1415167002623 FAD binding domain; Region: FAD_binding_4; pfam01565 1415167002624 Berberine and berberine like; Region: BBE; pfam08031 1415167002625 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1415167002626 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1415167002627 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1415167002628 tetramer interface [polypeptide binding]; other site 1415167002629 heme binding pocket [chemical binding]; other site 1415167002630 NADPH binding site [chemical binding]; other site 1415167002631 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1415167002632 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1415167002633 Walker A/P-loop; other site 1415167002634 ATP binding site [chemical binding]; other site 1415167002635 Q-loop/lid; other site 1415167002636 ABC transporter signature motif; other site 1415167002637 Walker B; other site 1415167002638 D-loop; other site 1415167002639 H-loop/switch region; other site 1415167002640 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1415167002641 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1415167002642 substrate binding pocket [chemical binding]; other site 1415167002643 membrane-bound complex binding site; other site 1415167002644 hinge residues; other site 1415167002645 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1415167002646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167002647 dimer interface [polypeptide binding]; other site 1415167002648 conserved gate region; other site 1415167002649 putative PBP binding loops; other site 1415167002650 ABC-ATPase subunit interface; other site 1415167002651 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1415167002652 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1415167002653 active site 1415167002654 dimer interface [polypeptide binding]; other site 1415167002655 non-prolyl cis peptide bond; other site 1415167002656 insertion regions; other site 1415167002657 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1415167002658 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1415167002659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167002660 non-specific DNA binding site [nucleotide binding]; other site 1415167002661 salt bridge; other site 1415167002662 sequence-specific DNA binding site [nucleotide binding]; other site 1415167002663 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1415167002664 epoxyqueuosine reductase; Region: TIGR00276 1415167002665 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1415167002666 Putative amidase domain; Region: Amidase_6; pfam12671 1415167002667 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1415167002668 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1415167002669 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1415167002670 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1415167002671 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1415167002672 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1415167002673 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1415167002674 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1415167002675 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167002676 MarR family; Region: MarR; pfam01047 1415167002677 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1415167002678 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1415167002679 carboxyltransferase (CT) interaction site; other site 1415167002680 biotinylation site [posttranslational modification]; other site 1415167002681 HlyD family secretion protein; Region: HlyD_3; pfam13437 1415167002682 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1415167002683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167002684 putative substrate translocation pore; other site 1415167002685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167002686 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1415167002687 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1415167002688 Predicted transcriptional regulators [Transcription]; Region: COG1725 1415167002689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167002690 DNA-binding site [nucleotide binding]; DNA binding site 1415167002691 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1415167002692 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1415167002693 Walker A/P-loop; other site 1415167002694 ATP binding site [chemical binding]; other site 1415167002695 Q-loop/lid; other site 1415167002696 ABC transporter signature motif; other site 1415167002697 Walker B; other site 1415167002698 D-loop; other site 1415167002699 H-loop/switch region; other site 1415167002700 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1415167002701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1415167002702 Walker A/P-loop; other site 1415167002703 ATP binding site [chemical binding]; other site 1415167002704 Q-loop/lid; other site 1415167002705 ABC transporter signature motif; other site 1415167002706 Walker B; other site 1415167002707 D-loop; other site 1415167002708 H-loop/switch region; other site 1415167002709 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1415167002710 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1415167002711 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1415167002712 DNA-binding site [nucleotide binding]; DNA binding site 1415167002713 RNA-binding motif; other site 1415167002714 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1415167002715 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1415167002716 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1415167002717 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1415167002718 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1415167002719 metal binding site [ion binding]; metal-binding site 1415167002720 active site 1415167002721 I-site; other site 1415167002722 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1415167002723 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1415167002724 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1415167002725 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1415167002726 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1415167002727 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1415167002728 active site 1415167002729 catalytic site [active] 1415167002730 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1415167002731 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1415167002732 RNA binding surface [nucleotide binding]; other site 1415167002733 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1415167002734 active site 1415167002735 FOG: CBS domain [General function prediction only]; Region: COG0517 1415167002736 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1415167002737 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1415167002738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167002739 motif II; other site 1415167002740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167002741 Coenzyme A binding pocket [chemical binding]; other site 1415167002742 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1415167002743 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1415167002744 putative active site [active] 1415167002745 catalytic triad [active] 1415167002746 putative dimer interface [polypeptide binding]; other site 1415167002747 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 1415167002748 aminotransferase; Validated; Region: PRK07678 1415167002749 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1415167002750 inhibitor-cofactor binding pocket; inhibition site 1415167002751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167002752 catalytic residue [active] 1415167002753 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1415167002754 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1415167002755 amphipathic channel; other site 1415167002756 Asn-Pro-Ala signature motifs; other site 1415167002757 glycerol kinase; Provisional; Region: glpK; PRK00047 1415167002758 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1415167002759 N- and C-terminal domain interface [polypeptide binding]; other site 1415167002760 active site 1415167002761 MgATP binding site [chemical binding]; other site 1415167002762 catalytic site [active] 1415167002763 metal binding site [ion binding]; metal-binding site 1415167002764 glycerol binding site [chemical binding]; other site 1415167002765 homotetramer interface [polypeptide binding]; other site 1415167002766 homodimer interface [polypeptide binding]; other site 1415167002767 FBP binding site [chemical binding]; other site 1415167002768 protein IIAGlc interface [polypeptide binding]; other site 1415167002769 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1415167002770 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1415167002771 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1415167002772 active site 1415167002773 substrate binding site [chemical binding]; other site 1415167002774 metal binding site [ion binding]; metal-binding site 1415167002775 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1415167002776 GAF domain; Region: GAF; pfam01590 1415167002777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1415167002778 Histidine kinase; Region: HisKA_3; pfam07730 1415167002779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167002780 ATP binding site [chemical binding]; other site 1415167002781 Mg2+ binding site [ion binding]; other site 1415167002782 G-X-G motif; other site 1415167002783 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1415167002784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167002785 active site 1415167002786 phosphorylation site [posttranslational modification] 1415167002787 intermolecular recognition site; other site 1415167002788 dimerization interface [polypeptide binding]; other site 1415167002789 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1415167002790 DNA binding residues [nucleotide binding] 1415167002791 dimerization interface [polypeptide binding]; other site 1415167002792 Predicted flavoprotein [General function prediction only]; Region: COG0431 1415167002793 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1415167002794 YhdB-like protein; Region: YhdB; pfam14148 1415167002795 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1415167002796 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167002797 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167002798 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167002799 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167002800 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167002801 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1415167002802 NlpC/P60 family; Region: NLPC_P60; pfam00877 1415167002803 Transcriptional regulator; Region: Rrf2; cl17282 1415167002804 Rrf2 family protein; Region: rrf2_super; TIGR00738 1415167002805 Conserved TM helix; Region: TM_helix; pfam05552 1415167002806 Conserved TM helix; Region: TM_helix; pfam05552 1415167002807 Conserved TM helix; Region: TM_helix; pfam05552 1415167002808 Conserved TM helix; Region: TM_helix; pfam05552 1415167002809 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1415167002810 SpoVR like protein; Region: SpoVR; pfam04293 1415167002811 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1415167002812 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1415167002813 dimer interface [polypeptide binding]; other site 1415167002814 active site 1415167002815 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167002816 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167002817 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167002818 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1415167002819 NlpC/P60 family; Region: NLPC_P60; pfam00877 1415167002820 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167002821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167002822 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1415167002823 dimerization interface [polypeptide binding]; other site 1415167002824 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1415167002825 dimer interface [polypeptide binding]; other site 1415167002826 Citrate synthase; Region: Citrate_synt; pfam00285 1415167002827 active site 1415167002828 citrylCoA binding site [chemical binding]; other site 1415167002829 oxalacetate/citrate binding site [chemical binding]; other site 1415167002830 coenzyme A binding site [chemical binding]; other site 1415167002831 catalytic triad [active] 1415167002832 short chain dehydrogenase; Provisional; Region: PRK06701 1415167002833 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1415167002834 NAD binding site [chemical binding]; other site 1415167002835 metal binding site [ion binding]; metal-binding site 1415167002836 active site 1415167002837 amino acid transporter; Region: 2A0306; TIGR00909 1415167002838 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1415167002839 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1415167002840 Na2 binding site [ion binding]; other site 1415167002841 putative substrate binding site 1 [chemical binding]; other site 1415167002842 Na binding site 1 [ion binding]; other site 1415167002843 putative substrate binding site 2 [chemical binding]; other site 1415167002844 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1415167002845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167002846 DNA-binding site [nucleotide binding]; DNA binding site 1415167002847 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167002848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167002849 homodimer interface [polypeptide binding]; other site 1415167002850 catalytic residue [active] 1415167002851 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1415167002852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167002853 Coenzyme A binding pocket [chemical binding]; other site 1415167002854 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1415167002855 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1415167002856 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1415167002857 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167002858 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167002859 DNA binding residues [nucleotide binding] 1415167002860 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1415167002861 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1415167002862 active site 1415167002863 catalytic tetrad [active] 1415167002864 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1415167002865 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1415167002866 putative acyl-acceptor binding pocket; other site 1415167002867 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1415167002868 Domain of unknown function DUF21; Region: DUF21; pfam01595 1415167002869 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1415167002870 Transporter associated domain; Region: CorC_HlyC; smart01091 1415167002871 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1415167002872 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1415167002873 DNA binding residues [nucleotide binding] 1415167002874 putative dimer interface [polypeptide binding]; other site 1415167002875 aspartate aminotransferase; Provisional; Region: PRK06836 1415167002876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167002877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167002878 homodimer interface [polypeptide binding]; other site 1415167002879 catalytic residue [active] 1415167002880 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1415167002881 Domain of unknown function DUF21; Region: DUF21; pfam01595 1415167002882 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1415167002883 Transporter associated domain; Region: CorC_HlyC; smart01091 1415167002884 camphor resistance protein CrcB; Provisional; Region: PRK14213 1415167002885 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1415167002886 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1415167002887 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1415167002888 active site 1415167002889 catalytic site [active] 1415167002890 metal binding site [ion binding]; metal-binding site 1415167002891 dimer interface [polypeptide binding]; other site 1415167002892 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1415167002893 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1415167002894 NAD-dependent deacetylase; Provisional; Region: PRK00481 1415167002895 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1415167002896 NAD+ binding site [chemical binding]; other site 1415167002897 substrate binding site [chemical binding]; other site 1415167002898 Zn binding site [ion binding]; other site 1415167002899 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1415167002900 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1415167002901 NodB motif; other site 1415167002902 active site 1415167002903 catalytic site [active] 1415167002904 Zn binding site [ion binding]; other site 1415167002905 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1415167002906 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1415167002907 homodimer interface [polypeptide binding]; other site 1415167002908 substrate-cofactor binding pocket; other site 1415167002909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167002910 catalytic residue [active] 1415167002911 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1415167002912 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1415167002913 Ligand Binding Site [chemical binding]; other site 1415167002914 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1415167002915 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1415167002916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1415167002917 Walker A/P-loop; other site 1415167002918 ATP binding site [chemical binding]; other site 1415167002919 Q-loop/lid; other site 1415167002920 ABC transporter signature motif; other site 1415167002921 Walker B; other site 1415167002922 D-loop; other site 1415167002923 H-loop/switch region; other site 1415167002924 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1415167002925 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1415167002926 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1415167002927 Walker A/P-loop; other site 1415167002928 ATP binding site [chemical binding]; other site 1415167002929 Q-loop/lid; other site 1415167002930 ABC transporter signature motif; other site 1415167002931 Walker B; other site 1415167002932 D-loop; other site 1415167002933 H-loop/switch region; other site 1415167002934 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1415167002935 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1415167002936 NAD binding site [chemical binding]; other site 1415167002937 substrate binding site [chemical binding]; other site 1415167002938 putative active site [active] 1415167002939 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1415167002940 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1415167002941 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1415167002942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1415167002943 hypothetical protein; Provisional; Region: PRK13676 1415167002944 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1415167002945 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1415167002946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167002947 active site 1415167002948 motif I; other site 1415167002949 motif II; other site 1415167002950 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1415167002951 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1415167002952 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1415167002953 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1415167002954 TrkA-C domain; Region: TrkA_C; pfam02080 1415167002955 enoyl-CoA hydratase; Provisional; Region: PRK07659 1415167002956 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1415167002957 substrate binding site [chemical binding]; other site 1415167002958 oxyanion hole (OAH) forming residues; other site 1415167002959 trimer interface [polypeptide binding]; other site 1415167002960 YhzD-like protein; Region: YhzD; pfam14120 1415167002961 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1415167002962 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1415167002963 Walker A/P-loop; other site 1415167002964 ATP binding site [chemical binding]; other site 1415167002965 Q-loop/lid; other site 1415167002966 ABC transporter signature motif; other site 1415167002967 Walker B; other site 1415167002968 D-loop; other site 1415167002969 H-loop/switch region; other site 1415167002970 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1415167002971 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1415167002972 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1415167002973 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1415167002974 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1415167002975 active site 1415167002976 metal binding site [ion binding]; metal-binding site 1415167002977 DNA binding site [nucleotide binding] 1415167002978 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1415167002979 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1415167002980 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1415167002981 generic binding surface II; other site 1415167002982 generic binding surface I; other site 1415167002983 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1415167002984 Zn2+ binding site [ion binding]; other site 1415167002985 Mg2+ binding site [ion binding]; other site 1415167002986 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1415167002987 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1415167002988 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1415167002989 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1415167002990 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1415167002991 transcriptional regulator Hpr; Provisional; Region: PRK13777 1415167002992 MarR family; Region: MarR; pfam01047 1415167002993 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1415167002994 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1415167002995 homodimer interface [polypeptide binding]; other site 1415167002996 substrate-cofactor binding pocket; other site 1415167002997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167002998 catalytic residue [active] 1415167002999 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1415167003000 HIT family signature motif; other site 1415167003001 catalytic residue [active] 1415167003002 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1415167003003 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1415167003004 Walker A/P-loop; other site 1415167003005 ATP binding site [chemical binding]; other site 1415167003006 Q-loop/lid; other site 1415167003007 ABC transporter signature motif; other site 1415167003008 Walker B; other site 1415167003009 D-loop; other site 1415167003010 H-loop/switch region; other site 1415167003011 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1415167003012 EcsC protein family; Region: EcsC; pfam12787 1415167003013 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1415167003014 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1415167003015 metal binding site [ion binding]; metal-binding site 1415167003016 dimer interface [polypeptide binding]; other site 1415167003017 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1415167003018 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1415167003019 Transglycosylase; Region: Transgly; pfam00912 1415167003020 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1415167003021 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1415167003022 substrate binding site [chemical binding]; other site 1415167003023 active site 1415167003024 ferrochelatase; Provisional; Region: PRK12435 1415167003025 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1415167003026 C-terminal domain interface [polypeptide binding]; other site 1415167003027 active site 1415167003028 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1415167003029 active site 1415167003030 N-terminal domain interface [polypeptide binding]; other site 1415167003031 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1415167003032 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1415167003033 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167003034 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167003035 Predicted membrane protein [Function unknown]; Region: COG1511 1415167003036 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1415167003037 Pex19 protein family; Region: Pex19; pfam04614 1415167003038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167003039 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1415167003040 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1415167003041 dimer interface [polypeptide binding]; other site 1415167003042 active site 1415167003043 CoA binding pocket [chemical binding]; other site 1415167003044 Predicted membrane protein [Function unknown]; Region: COG4377 1415167003045 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1415167003046 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1415167003047 putative oligomer interface [polypeptide binding]; other site 1415167003048 putative active site [active] 1415167003049 metal binding site [ion binding]; metal-binding site 1415167003050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4405 1415167003051 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1415167003052 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1415167003053 YhfH-like protein; Region: YhfH; pfam14149 1415167003054 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1415167003055 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1415167003056 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1415167003057 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1415167003058 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1415167003059 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1415167003060 NAD(P) binding site [chemical binding]; other site 1415167003061 putative active site [active] 1415167003062 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1415167003063 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1415167003064 acyl-activating enzyme (AAE) consensus motif; other site 1415167003065 putative AMP binding site [chemical binding]; other site 1415167003066 putative active site [active] 1415167003067 putative CoA binding site [chemical binding]; other site 1415167003068 Peptidase family M48; Region: Peptidase_M48; pfam01435 1415167003069 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1415167003070 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1415167003071 active site 1415167003072 catalytic residues [active] 1415167003073 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1415167003074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167003075 Coenzyme A binding pocket [chemical binding]; other site 1415167003076 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1415167003077 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1415167003078 putative NADP binding site [chemical binding]; other site 1415167003079 putative dimer interface [polypeptide binding]; other site 1415167003080 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1415167003081 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1415167003082 siderophore binding site; other site 1415167003083 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1415167003084 catalytic core [active] 1415167003085 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1415167003086 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1415167003087 dimer interface [polypeptide binding]; other site 1415167003088 active site 1415167003089 acyl-CoA synthetase; Validated; Region: PRK07638 1415167003090 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1415167003091 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1415167003092 acyl-activating enzyme (AAE) consensus motif; other site 1415167003093 acyl-activating enzyme (AAE) consensus motif; other site 1415167003094 AMP binding site [chemical binding]; other site 1415167003095 active site 1415167003096 CoA binding site [chemical binding]; other site 1415167003097 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1415167003098 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1415167003099 heme-binding site [chemical binding]; other site 1415167003100 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1415167003101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1415167003102 dimer interface [polypeptide binding]; other site 1415167003103 putative CheW interface [polypeptide binding]; other site 1415167003104 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1415167003105 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1415167003106 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1415167003107 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1415167003108 [2Fe-2S] cluster binding site [ion binding]; other site 1415167003109 short chain dehydrogenase; Provisional; Region: PRK06701 1415167003110 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1415167003111 NAD binding site [chemical binding]; other site 1415167003112 metal binding site [ion binding]; metal-binding site 1415167003113 active site 1415167003114 IDEAL domain; Region: IDEAL; pfam08858 1415167003115 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1415167003116 oxidoreductase; Provisional; Region: PRK07985 1415167003117 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1415167003118 NAD binding site [chemical binding]; other site 1415167003119 metal binding site [ion binding]; metal-binding site 1415167003120 active site 1415167003121 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1415167003122 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1415167003123 Na binding site [ion binding]; other site 1415167003124 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1415167003125 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1415167003126 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1415167003127 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1415167003128 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1415167003129 Catalytic site [active] 1415167003130 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1415167003131 hypothetical protein; Provisional; Region: PRK08244 1415167003132 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1415167003133 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167003134 MarR family; Region: MarR; pfam01047 1415167003135 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1415167003136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167003137 putative substrate translocation pore; other site 1415167003138 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1415167003139 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1415167003140 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1415167003141 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1415167003142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167003143 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1415167003144 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1415167003145 inhibitor-cofactor binding pocket; inhibition site 1415167003146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167003147 catalytic residue [active] 1415167003148 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1415167003149 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1415167003150 DNA binding site [nucleotide binding] 1415167003151 domain linker motif; other site 1415167003152 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1415167003153 putative dimerization interface [polypeptide binding]; other site 1415167003154 putative ligand binding site [chemical binding]; other site 1415167003155 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1415167003156 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1415167003157 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1415167003158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167003159 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167003160 putative substrate translocation pore; other site 1415167003161 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1415167003162 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1415167003163 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1415167003164 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1415167003165 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1415167003166 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1415167003167 dinuclear metal binding motif [ion binding]; other site 1415167003168 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1415167003169 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1415167003170 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1415167003171 Part of AAA domain; Region: AAA_19; pfam13245 1415167003172 Family description; Region: UvrD_C_2; pfam13538 1415167003173 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1415167003174 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1415167003175 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1415167003176 active site 1415167003177 metal binding site [ion binding]; metal-binding site 1415167003178 DNA binding site [nucleotide binding] 1415167003179 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1415167003180 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1415167003181 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1415167003182 Walker A/P-loop; other site 1415167003183 ATP binding site [chemical binding]; other site 1415167003184 Q-loop/lid; other site 1415167003185 ABC transporter signature motif; other site 1415167003186 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1415167003187 ABC transporter signature motif; other site 1415167003188 Walker B; other site 1415167003189 D-loop; other site 1415167003190 H-loop/switch region; other site 1415167003191 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1415167003192 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1415167003193 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1415167003194 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1415167003195 Spore germination protein GerPC; Region: GerPC; pfam10737 1415167003196 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1415167003197 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1415167003198 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1415167003199 CotH protein; Region: CotH; pfam08757 1415167003200 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1415167003201 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1415167003202 hypothetical protein; Provisional; Region: PRK13673 1415167003203 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1415167003204 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1415167003205 active site 1415167003206 catalytic triad [active] 1415167003207 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1415167003208 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1415167003209 active site 1415167003210 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1415167003211 dimer interface [polypeptide binding]; other site 1415167003212 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1415167003213 Ligand Binding Site [chemical binding]; other site 1415167003214 Molecular Tunnel; other site 1415167003215 DinB family; Region: DinB; cl17821 1415167003216 DinB superfamily; Region: DinB_2; pfam12867 1415167003217 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1415167003218 substrate binding pocket [chemical binding]; other site 1415167003219 aspartate-rich region 2; other site 1415167003220 substrate-Mg2+ binding site; other site 1415167003221 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1415167003222 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1415167003223 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1415167003224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167003225 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1415167003226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167003227 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1415167003228 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1415167003229 DNA binding site [nucleotide binding] 1415167003230 domain linker motif; other site 1415167003231 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1415167003232 dimerization interface [polypeptide binding]; other site 1415167003233 ligand binding site [chemical binding]; other site 1415167003234 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1415167003235 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1415167003236 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1415167003237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1415167003238 Lysine efflux permease [General function prediction only]; Region: COG1279 1415167003239 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1415167003240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167003241 DNA-binding site [nucleotide binding]; DNA binding site 1415167003242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167003243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167003244 homodimer interface [polypeptide binding]; other site 1415167003245 catalytic residue [active] 1415167003246 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1415167003247 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1415167003248 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1415167003249 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1415167003250 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1415167003251 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1415167003252 ligand-binding site [chemical binding]; other site 1415167003253 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1415167003254 ATP-sulfurylase; Region: ATPS; cd00517 1415167003255 active site 1415167003256 HXXH motif; other site 1415167003257 flexible loop; other site 1415167003258 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1415167003259 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1415167003260 Active Sites [active] 1415167003261 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1415167003262 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 1415167003263 (2R)-phospho-3-sulfolactate synthase (PSL synthase, CoM biosynthesis) [Coenzyme transport and metabolism]; Region: COG1809 1415167003264 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1415167003265 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167003266 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1415167003267 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1415167003268 active site pocket [active] 1415167003269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167003270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167003271 putative substrate translocation pore; other site 1415167003272 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1415167003273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167003274 Coenzyme A binding pocket [chemical binding]; other site 1415167003275 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1415167003276 Coenzyme A binding pocket [chemical binding]; other site 1415167003277 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1415167003278 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1415167003279 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1415167003280 FAD binding site [chemical binding]; other site 1415167003281 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1415167003282 S1 domain; Region: S1_2; pfam13509 1415167003283 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1415167003284 RNA binding site [nucleotide binding]; other site 1415167003285 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1415167003286 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1415167003287 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 1415167003288 Predicted transcriptional regulators [Transcription]; Region: COG1695 1415167003289 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1415167003290 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1415167003291 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1415167003292 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1415167003293 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1415167003294 active site 1415167003295 Zn binding site [ion binding]; other site 1415167003296 EDD domain protein, DegV family; Region: DegV; TIGR00762 1415167003297 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1415167003298 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1415167003299 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167003300 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167003301 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1415167003302 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1415167003303 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1415167003304 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1415167003305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167003306 motif II; other site 1415167003307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167003308 esterase; Provisional; Region: PRK10566 1415167003309 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1415167003310 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1415167003311 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1415167003312 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1415167003313 FAD binding domain; Region: FAD_binding_4; pfam01565 1415167003314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167003315 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167003316 putative substrate translocation pore; other site 1415167003317 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1415167003318 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1415167003319 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1415167003320 heterotetramer interface [polypeptide binding]; other site 1415167003321 active site pocket [active] 1415167003322 cleavage site 1415167003323 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1415167003324 nucleotide binding site [chemical binding]; other site 1415167003325 N-acetyl-L-glutamate binding site [chemical binding]; other site 1415167003326 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1415167003327 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1415167003328 inhibitor-cofactor binding pocket; inhibition site 1415167003329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167003330 catalytic residue [active] 1415167003331 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1415167003332 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1415167003333 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1415167003334 catalytic site [active] 1415167003335 subunit interface [polypeptide binding]; other site 1415167003336 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1415167003337 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1415167003338 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1415167003339 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1415167003340 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1415167003341 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1415167003342 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1415167003343 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1415167003344 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1415167003345 YjzC-like protein; Region: YjzC; pfam14168 1415167003346 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1415167003347 UDP-apiose/xylose synthase; Region: PLN02427 1415167003348 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1415167003349 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1415167003350 putative ligand binding site [chemical binding]; other site 1415167003351 ComZ; Region: ComZ; pfam10815 1415167003352 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1415167003353 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1415167003354 dimer interface [polypeptide binding]; other site 1415167003355 active site 1415167003356 CoA binding pocket [chemical binding]; other site 1415167003357 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1415167003358 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1415167003359 dimer interface [polypeptide binding]; other site 1415167003360 active site 1415167003361 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1415167003362 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1415167003363 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1415167003364 Walker A/P-loop; other site 1415167003365 ATP binding site [chemical binding]; other site 1415167003366 Q-loop/lid; other site 1415167003367 ABC transporter signature motif; other site 1415167003368 Walker B; other site 1415167003369 D-loop; other site 1415167003370 H-loop/switch region; other site 1415167003371 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1415167003372 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1415167003373 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1415167003374 Walker A/P-loop; other site 1415167003375 ATP binding site [chemical binding]; other site 1415167003376 Q-loop/lid; other site 1415167003377 ABC transporter signature motif; other site 1415167003378 Walker B; other site 1415167003379 D-loop; other site 1415167003380 H-loop/switch region; other site 1415167003381 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1415167003382 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1415167003383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167003384 dimer interface [polypeptide binding]; other site 1415167003385 conserved gate region; other site 1415167003386 putative PBP binding loops; other site 1415167003387 ABC-ATPase subunit interface; other site 1415167003388 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1415167003389 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1415167003390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167003391 dimer interface [polypeptide binding]; other site 1415167003392 conserved gate region; other site 1415167003393 putative PBP binding loops; other site 1415167003394 ABC-ATPase subunit interface; other site 1415167003395 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1415167003396 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1415167003397 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1415167003398 active site 1415167003399 HIGH motif; other site 1415167003400 dimer interface [polypeptide binding]; other site 1415167003401 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1415167003402 KMSKS motif; other site 1415167003403 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1415167003404 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1415167003405 peptide binding site [polypeptide binding]; other site 1415167003406 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1415167003407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167003408 dimer interface [polypeptide binding]; other site 1415167003409 conserved gate region; other site 1415167003410 putative PBP binding loops; other site 1415167003411 ABC-ATPase subunit interface; other site 1415167003412 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1415167003413 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1415167003414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167003415 dimer interface [polypeptide binding]; other site 1415167003416 conserved gate region; other site 1415167003417 putative PBP binding loops; other site 1415167003418 ABC-ATPase subunit interface; other site 1415167003419 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1415167003420 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1415167003421 Walker A/P-loop; other site 1415167003422 ATP binding site [chemical binding]; other site 1415167003423 Q-loop/lid; other site 1415167003424 ABC transporter signature motif; other site 1415167003425 Walker B; other site 1415167003426 D-loop; other site 1415167003427 H-loop/switch region; other site 1415167003428 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1415167003429 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1415167003430 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1415167003431 Walker A/P-loop; other site 1415167003432 ATP binding site [chemical binding]; other site 1415167003433 Q-loop/lid; other site 1415167003434 ABC transporter signature motif; other site 1415167003435 Walker B; other site 1415167003436 D-loop; other site 1415167003437 H-loop/switch region; other site 1415167003438 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1415167003439 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1415167003440 ArsC family; Region: ArsC; pfam03960 1415167003441 putative catalytic residues [active] 1415167003442 thiol/disulfide switch; other site 1415167003443 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1415167003444 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 1415167003445 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 1415167003446 oligoendopeptidase F; Region: pepF; TIGR00181 1415167003447 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1415167003448 active site 1415167003449 Zn binding site [ion binding]; other site 1415167003450 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1415167003451 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1415167003452 catalytic residues [active] 1415167003453 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1415167003454 apolar tunnel; other site 1415167003455 heme binding site [chemical binding]; other site 1415167003456 dimerization interface [polypeptide binding]; other site 1415167003457 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1415167003458 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1415167003459 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1415167003460 catalytic residue [active] 1415167003461 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1415167003462 putative active site [active] 1415167003463 putative metal binding residues [ion binding]; other site 1415167003464 signature motif; other site 1415167003465 putative triphosphate binding site [ion binding]; other site 1415167003466 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1415167003467 synthetase active site [active] 1415167003468 NTP binding site [chemical binding]; other site 1415167003469 metal binding site [ion binding]; metal-binding site 1415167003470 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1415167003471 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1415167003472 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1415167003473 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1415167003474 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1415167003475 active site 1415167003476 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1415167003477 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1415167003478 active site 1415167003479 metal binding site [ion binding]; metal-binding site 1415167003480 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1415167003481 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1415167003482 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1415167003483 TrkA-N domain; Region: TrkA_N; pfam02254 1415167003484 TrkA-C domain; Region: TrkA_C; pfam02080 1415167003485 thiaminase II; Region: salvage_TenA; TIGR04306 1415167003486 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1415167003487 thiamine phosphate binding site [chemical binding]; other site 1415167003488 active site 1415167003489 pyrophosphate binding site [ion binding]; other site 1415167003490 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1415167003491 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1415167003492 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1415167003493 thiS-thiF/thiG interaction site; other site 1415167003494 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1415167003495 ThiS interaction site; other site 1415167003496 putative active site [active] 1415167003497 tetramer interface [polypeptide binding]; other site 1415167003498 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1415167003499 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1415167003500 ATP binding site [chemical binding]; other site 1415167003501 substrate interface [chemical binding]; other site 1415167003502 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1415167003503 dimer interface [polypeptide binding]; other site 1415167003504 substrate binding site [chemical binding]; other site 1415167003505 ATP binding site [chemical binding]; other site 1415167003506 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1415167003507 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1415167003508 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1415167003509 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1415167003510 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1415167003511 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1415167003512 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1415167003513 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1415167003514 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1415167003515 Part of AAA domain; Region: AAA_19; pfam13245 1415167003516 Family description; Region: UvrD_C_2; pfam13538 1415167003517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167003518 Coenzyme A binding pocket [chemical binding]; other site 1415167003519 hypothetical protein; Provisional; Region: PRK13679 1415167003520 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1415167003521 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1415167003522 Putative esterase; Region: Esterase; pfam00756 1415167003523 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1415167003524 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1415167003525 homodimer interface [polypeptide binding]; other site 1415167003526 substrate-cofactor binding pocket; other site 1415167003527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167003528 catalytic residue [active] 1415167003529 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1415167003530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1415167003531 Predicted integral membrane protein [Function unknown]; Region: COG5505 1415167003532 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1415167003533 YjcQ protein; Region: YjcQ; pfam09639 1415167003534 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1415167003535 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1415167003536 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1415167003537 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 1415167003538 classical (c) SDRs; Region: SDR_c; cd05233 1415167003539 NAD(P) binding site [chemical binding]; other site 1415167003540 active site 1415167003541 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1415167003542 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1415167003543 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1415167003544 HTH domain; Region: HTH_11; pfam08279 1415167003545 PRD domain; Region: PRD; pfam00874 1415167003546 PRD domain; Region: PRD; pfam00874 1415167003547 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1415167003548 active site 1415167003549 P-loop; other site 1415167003550 phosphorylation site [posttranslational modification] 1415167003551 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1415167003552 active site 1415167003553 phosphorylation site [posttranslational modification] 1415167003554 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1415167003555 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1415167003556 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1415167003557 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1415167003558 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1415167003559 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1415167003560 putative deacylase active site [active] 1415167003561 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1415167003562 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1415167003563 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 1415167003564 UbiA prenyltransferase family; Region: UbiA; pfam01040 1415167003565 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1415167003566 Putative motility protein; Region: YjfB_motility; pfam14070 1415167003567 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1415167003568 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1415167003569 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1415167003570 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1415167003571 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1415167003572 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1415167003573 nudix motif; other site 1415167003574 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1415167003575 Cytochrome P450; Region: p450; cl12078 1415167003576 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1415167003577 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1415167003578 active site 1415167003579 TDP-binding site; other site 1415167003580 acceptor substrate-binding pocket; other site 1415167003581 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1415167003582 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1415167003583 active site 1415167003584 TIGR00245 family protein; Region: TIGR00245 1415167003585 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1415167003586 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1415167003587 Walker A/P-loop; other site 1415167003588 ATP binding site [chemical binding]; other site 1415167003589 Q-loop/lid; other site 1415167003590 ABC transporter signature motif; other site 1415167003591 Walker B; other site 1415167003592 D-loop; other site 1415167003593 H-loop/switch region; other site 1415167003594 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1415167003595 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1415167003596 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1415167003597 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1415167003598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1415167003599 Glucuronate isomerase; Region: UxaC; pfam02614 1415167003600 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1415167003601 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1415167003602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167003603 putative substrate translocation pore; other site 1415167003604 Malate/L-lactate dehydrogenase; Region: Ldh_2; pfam02615 1415167003605 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1415167003606 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1415167003607 putative NAD(P) binding site [chemical binding]; other site 1415167003608 catalytic Zn binding site [ion binding]; other site 1415167003609 structural Zn binding site [ion binding]; other site 1415167003610 mannonate dehydratase; Provisional; Region: PRK03906 1415167003611 mannonate dehydratase; Region: uxuA; TIGR00695 1415167003612 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1415167003613 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1415167003614 putative NAD(P) binding site [chemical binding]; other site 1415167003615 active site 1415167003616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167003617 D-galactonate transporter; Region: 2A0114; TIGR00893 1415167003618 putative substrate translocation pore; other site 1415167003619 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1415167003620 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1415167003621 DNA binding site [nucleotide binding] 1415167003622 domain linker motif; other site 1415167003623 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1415167003624 dimerization interface [polypeptide binding]; other site 1415167003625 ligand binding site [chemical binding]; other site 1415167003626 altronate oxidoreductase; Provisional; Region: PRK03643 1415167003627 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1415167003628 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1415167003629 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1415167003630 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1415167003631 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1415167003632 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1415167003633 DinB family; Region: DinB; pfam05163 1415167003634 DinB superfamily; Region: DinB_2; pfam12867 1415167003635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167003636 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1415167003637 Walker A motif; other site 1415167003638 ATP binding site [chemical binding]; other site 1415167003639 Walker B motif; other site 1415167003640 arginine finger; other site 1415167003641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167003642 binding surface 1415167003643 TPR motif; other site 1415167003644 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1415167003645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167003646 binding surface 1415167003647 TPR motif; other site 1415167003648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1415167003649 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1415167003650 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1415167003651 amidase catalytic site [active] 1415167003652 Zn binding residues [ion binding]; other site 1415167003653 substrate binding site [chemical binding]; other site 1415167003654 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1415167003655 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167003656 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1415167003657 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1415167003658 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1415167003659 pentamer interface [polypeptide binding]; other site 1415167003660 dodecaamer interface [polypeptide binding]; other site 1415167003661 Phage-related replication protein [General function prediction only]; Region: COG4195 1415167003662 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1415167003663 dimanganese center [ion binding]; other site 1415167003664 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1415167003665 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1415167003666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167003667 non-specific DNA binding site [nucleotide binding]; other site 1415167003668 salt bridge; other site 1415167003669 sequence-specific DNA binding site [nucleotide binding]; other site 1415167003670 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1415167003671 putative Zn2+ binding site [ion binding]; other site 1415167003672 putative DNA binding site [nucleotide binding]; other site 1415167003673 hypothetical protein; Provisional; Region: PRK06921 1415167003674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167003675 Walker A motif; other site 1415167003676 ATP binding site [chemical binding]; other site 1415167003677 Walker B motif; other site 1415167003678 positive control sigma-like factor; Validated; Region: PRK06930 1415167003679 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167003680 DNA binding residues [nucleotide binding] 1415167003681 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1415167003682 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1415167003683 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1415167003684 Terminase-like family; Region: Terminase_6; pfam03237 1415167003685 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1415167003686 Phage capsid family; Region: Phage_capsid; pfam05065 1415167003687 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1415167003688 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1415167003689 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1415167003690 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1415167003691 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1415167003692 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1415167003693 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1415167003694 catalytic residue [active] 1415167003695 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1415167003696 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167003697 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 1415167003698 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1415167003699 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1415167003700 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1415167003701 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1415167003702 XkdW protein; Region: XkdW; pfam09636 1415167003703 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1415167003704 Haemolysin XhlA; Region: XhlA; pfam10779 1415167003705 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1415167003706 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1415167003707 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1415167003708 amidase catalytic site [active] 1415167003709 Zn binding residues [ion binding]; other site 1415167003710 substrate binding site [chemical binding]; other site 1415167003711 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167003712 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1415167003713 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1415167003714 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1415167003715 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1415167003716 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1415167003717 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1415167003718 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1415167003719 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1415167003720 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167003721 Zn binding site [ion binding]; other site 1415167003722 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1415167003723 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167003724 Zn binding site [ion binding]; other site 1415167003725 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1415167003726 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1415167003727 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1415167003728 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1415167003729 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1415167003730 Ligand binding site; other site 1415167003731 Putative Catalytic site; other site 1415167003732 DXD motif; other site 1415167003733 Trypsin; Region: Trypsin; pfam00089 1415167003734 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1415167003735 protein binding site [polypeptide binding]; other site 1415167003736 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 1415167003737 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1415167003738 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1415167003739 SxDxEG motif; other site 1415167003740 active site 1415167003741 metal binding site [ion binding]; metal-binding site 1415167003742 homopentamer interface [polypeptide binding]; other site 1415167003743 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1415167003744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167003745 dimer interface [polypeptide binding]; other site 1415167003746 conserved gate region; other site 1415167003747 putative PBP binding loops; other site 1415167003748 ABC-ATPase subunit interface; other site 1415167003749 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1415167003750 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1415167003751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167003752 dimer interface [polypeptide binding]; other site 1415167003753 conserved gate region; other site 1415167003754 putative PBP binding loops; other site 1415167003755 ABC-ATPase subunit interface; other site 1415167003756 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1415167003757 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1415167003758 Walker A/P-loop; other site 1415167003759 ATP binding site [chemical binding]; other site 1415167003760 Q-loop/lid; other site 1415167003761 ABC transporter signature motif; other site 1415167003762 Walker B; other site 1415167003763 D-loop; other site 1415167003764 H-loop/switch region; other site 1415167003765 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1415167003766 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1415167003767 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1415167003768 peptide binding site [polypeptide binding]; other site 1415167003769 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1415167003770 dimer interface [polypeptide binding]; other site 1415167003771 catalytic triad [active] 1415167003772 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1415167003773 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1415167003774 active site 1415167003775 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1415167003776 NlpC/P60 family; Region: NLPC_P60; pfam00877 1415167003777 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1415167003778 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1415167003779 Walker A/P-loop; other site 1415167003780 ATP binding site [chemical binding]; other site 1415167003781 Q-loop/lid; other site 1415167003782 ABC transporter signature motif; other site 1415167003783 Walker B; other site 1415167003784 D-loop; other site 1415167003785 H-loop/switch region; other site 1415167003786 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1415167003787 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1415167003788 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1415167003789 Amidinotransferase; Region: Amidinotransf; pfam02274 1415167003790 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1415167003791 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1415167003792 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1415167003793 heme-binding site [chemical binding]; other site 1415167003794 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1415167003795 FAD binding pocket [chemical binding]; other site 1415167003796 FAD binding motif [chemical binding]; other site 1415167003797 phosphate binding motif [ion binding]; other site 1415167003798 beta-alpha-beta structure motif; other site 1415167003799 NAD binding pocket [chemical binding]; other site 1415167003800 Heme binding pocket [chemical binding]; other site 1415167003801 Predicted membrane protein [Function unknown]; Region: COG2323 1415167003802 DinB superfamily; Region: DinB_2; pfam12867 1415167003803 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1415167003804 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1415167003805 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1415167003806 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1415167003807 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1415167003808 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1415167003809 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1415167003810 putative active site [active] 1415167003811 putative substrate binding site [chemical binding]; other site 1415167003812 putative cosubstrate binding site; other site 1415167003813 catalytic site [active] 1415167003814 glutamate 5-kinase; Region: proB; TIGR01027 1415167003815 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1415167003816 nucleotide binding site [chemical binding]; other site 1415167003817 homotetrameric interface [polypeptide binding]; other site 1415167003818 putative phosphate binding site [ion binding]; other site 1415167003819 putative allosteric binding site; other site 1415167003820 PUA domain; Region: PUA; pfam01472 1415167003821 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1415167003822 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1415167003823 putative catalytic cysteine [active] 1415167003824 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1415167003825 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167003826 MarR family; Region: MarR; pfam01047 1415167003827 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1415167003828 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1415167003829 nucleoside/Zn binding site; other site 1415167003830 dimer interface [polypeptide binding]; other site 1415167003831 catalytic motif [active] 1415167003832 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1415167003833 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1415167003834 THF binding site; other site 1415167003835 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1415167003836 substrate binding site [chemical binding]; other site 1415167003837 THF binding site; other site 1415167003838 zinc-binding site [ion binding]; other site 1415167003839 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1415167003840 active site 1415167003841 catalytic residues [active] 1415167003842 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1415167003843 Cobalt transport protein; Region: CbiQ; pfam02361 1415167003844 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1415167003845 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1415167003846 Walker A/P-loop; other site 1415167003847 ATP binding site [chemical binding]; other site 1415167003848 Q-loop/lid; other site 1415167003849 ABC transporter signature motif; other site 1415167003850 Walker B; other site 1415167003851 D-loop; other site 1415167003852 H-loop/switch region; other site 1415167003853 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1415167003854 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1415167003855 Walker A/P-loop; other site 1415167003856 ATP binding site [chemical binding]; other site 1415167003857 Q-loop/lid; other site 1415167003858 ABC transporter signature motif; other site 1415167003859 Walker B; other site 1415167003860 D-loop; other site 1415167003861 H-loop/switch region; other site 1415167003862 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1415167003863 YKOF-related Family; Region: Ykof; pfam07615 1415167003864 YKOF-related Family; Region: Ykof; pfam07615 1415167003865 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1415167003866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167003867 active site 1415167003868 phosphorylation site [posttranslational modification] 1415167003869 intermolecular recognition site; other site 1415167003870 dimerization interface [polypeptide binding]; other site 1415167003871 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1415167003872 DNA binding site [nucleotide binding] 1415167003873 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1415167003874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167003875 dimerization interface [polypeptide binding]; other site 1415167003876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167003877 dimer interface [polypeptide binding]; other site 1415167003878 phosphorylation site [posttranslational modification] 1415167003879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167003880 ATP binding site [chemical binding]; other site 1415167003881 Mg2+ binding site [ion binding]; other site 1415167003882 G-X-G motif; other site 1415167003883 Predicted membrane protein [Function unknown]; Region: COG3212 1415167003884 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1415167003885 Predicted membrane protein [Function unknown]; Region: COG3212 1415167003886 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1415167003887 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1415167003888 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1415167003889 MgtE intracellular N domain; Region: MgtE_N; smart00924 1415167003890 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1415167003891 Divalent cation transporter; Region: MgtE; pfam01769 1415167003892 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1415167003893 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1415167003894 DNA binding residues [nucleotide binding] 1415167003895 putative dimer interface [polypeptide binding]; other site 1415167003896 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167003897 MarR family; Region: MarR; pfam01047 1415167003898 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 1415167003899 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1415167003900 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1415167003901 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1415167003902 putative active site [active] 1415167003903 putative metal binding site [ion binding]; other site 1415167003904 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1415167003905 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1415167003906 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1415167003907 Ligand binding site; other site 1415167003908 Putative Catalytic site; other site 1415167003909 DXD motif; other site 1415167003910 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1415167003911 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1415167003912 DNA binding site [nucleotide binding] 1415167003913 active site 1415167003914 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1415167003915 nucleotide binding site [chemical binding]; other site 1415167003916 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1415167003917 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1415167003918 putative DNA binding site [nucleotide binding]; other site 1415167003919 putative homodimer interface [polypeptide binding]; other site 1415167003920 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1415167003921 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1415167003922 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1415167003923 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1415167003924 PAS domain; Region: PAS_9; pfam13426 1415167003925 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1415167003926 metal binding site [ion binding]; metal-binding site 1415167003927 active site 1415167003928 I-site; other site 1415167003929 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1415167003930 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1415167003931 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1415167003932 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1415167003933 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1415167003934 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167003935 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1415167003936 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1415167003937 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1415167003938 heat shock protein HtpX; Provisional; Region: PRK05457 1415167003939 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1415167003940 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1415167003941 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1415167003942 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1415167003943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167003944 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1415167003945 putative active site [active] 1415167003946 heme pocket [chemical binding]; other site 1415167003947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1415167003948 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1415167003949 putative active site [active] 1415167003950 heme pocket [chemical binding]; other site 1415167003951 PAS domain; Region: PAS; smart00091 1415167003952 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1415167003953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167003954 putative active site [active] 1415167003955 heme pocket [chemical binding]; other site 1415167003956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167003957 dimer interface [polypeptide binding]; other site 1415167003958 phosphorylation site [posttranslational modification] 1415167003959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167003960 ATP binding site [chemical binding]; other site 1415167003961 Mg2+ binding site [ion binding]; other site 1415167003962 G-X-G motif; other site 1415167003963 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1415167003964 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1415167003965 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1415167003966 DNA binding site [nucleotide binding] 1415167003967 active site 1415167003968 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1415167003969 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1415167003970 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1415167003971 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1415167003972 putative active site [active] 1415167003973 catalytic triad [active] 1415167003974 putative dimer interface [polypeptide binding]; other site 1415167003975 transaminase; Reviewed; Region: PRK08068 1415167003976 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167003977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167003978 homodimer interface [polypeptide binding]; other site 1415167003979 catalytic residue [active] 1415167003980 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 1415167003981 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1415167003982 dimer interface [polypeptide binding]; other site 1415167003983 active site 1415167003984 catalytic residue [active] 1415167003985 metal binding site [ion binding]; metal-binding site 1415167003986 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1415167003987 Cupin domain; Region: Cupin_2; pfam07883 1415167003988 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1415167003989 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1415167003990 Cache domain; Region: Cache_1; pfam02743 1415167003991 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1415167003992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167003993 dimer interface [polypeptide binding]; other site 1415167003994 phosphorylation site [posttranslational modification] 1415167003995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167003996 ATP binding site [chemical binding]; other site 1415167003997 Mg2+ binding site [ion binding]; other site 1415167003998 G-X-G motif; other site 1415167003999 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167004000 MarR family; Region: MarR; pfam01047 1415167004001 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1415167004002 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1415167004003 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1415167004004 ligand binding site [chemical binding]; other site 1415167004005 flagellar motor protein MotA; Validated; Region: PRK08124 1415167004006 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1415167004007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167004008 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1415167004009 Walker A motif; other site 1415167004010 ATP binding site [chemical binding]; other site 1415167004011 Walker B motif; other site 1415167004012 arginine finger; other site 1415167004013 UvrB/uvrC motif; Region: UVR; pfam02151 1415167004014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167004015 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1415167004016 Walker A motif; other site 1415167004017 ATP binding site [chemical binding]; other site 1415167004018 Walker B motif; other site 1415167004019 arginine finger; other site 1415167004020 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1415167004021 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1415167004022 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1415167004023 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1415167004024 Ligand Binding Site [chemical binding]; other site 1415167004025 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1415167004026 active site 1415167004027 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1415167004028 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167004029 FeS/SAM binding site; other site 1415167004030 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1415167004031 Predicted transcriptional regulators [Transcription]; Region: COG1733 1415167004032 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1415167004033 short chain dehydrogenase; Provisional; Region: PRK06500 1415167004034 classical (c) SDRs; Region: SDR_c; cd05233 1415167004035 NAD(P) binding site [chemical binding]; other site 1415167004036 active site 1415167004037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1415167004038 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1415167004039 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1415167004040 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1415167004041 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167004042 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1415167004043 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167004044 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1415167004045 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1415167004046 active site 1415167004047 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1415167004048 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1415167004049 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1415167004050 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1415167004051 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1415167004052 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1415167004053 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1415167004054 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1415167004055 catalytic residues [active] 1415167004056 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1415167004057 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1415167004058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167004059 motif II; other site 1415167004060 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1415167004061 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1415167004062 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1415167004063 active site 1415167004064 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1415167004065 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1415167004066 DNA binding site [nucleotide binding] 1415167004067 domain linker motif; other site 1415167004068 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1415167004069 putative dimerization interface [polypeptide binding]; other site 1415167004070 putative ligand binding site [chemical binding]; other site 1415167004071 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1415167004072 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1415167004073 PRD domain; Region: PRD; pfam00874 1415167004074 PRD domain; Region: PRD; pfam00874 1415167004075 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1415167004076 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1415167004077 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1415167004078 active site turn [active] 1415167004079 phosphorylation site [posttranslational modification] 1415167004080 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1415167004081 HPr interaction site; other site 1415167004082 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1415167004083 active site 1415167004084 phosphorylation site [posttranslational modification] 1415167004085 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1415167004086 dimerization domain swap beta strand [polypeptide binding]; other site 1415167004087 regulatory protein interface [polypeptide binding]; other site 1415167004088 active site 1415167004089 regulatory phosphorylation site [posttranslational modification]; other site 1415167004090 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1415167004091 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1415167004092 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1415167004093 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1415167004094 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1415167004095 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1415167004096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167004097 FeS/SAM binding site; other site 1415167004098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167004099 Coenzyme A binding pocket [chemical binding]; other site 1415167004100 Cache domain; Region: Cache_1; pfam02743 1415167004101 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167004102 dimerization interface [polypeptide binding]; other site 1415167004103 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1415167004104 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1415167004105 dimer interface [polypeptide binding]; other site 1415167004106 putative CheW interface [polypeptide binding]; other site 1415167004107 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1415167004108 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1415167004109 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1415167004110 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1415167004111 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1415167004112 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1415167004113 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1415167004114 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1415167004115 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167004116 putative active site [active] 1415167004117 heme pocket [chemical binding]; other site 1415167004118 PAS fold; Region: PAS; pfam00989 1415167004119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167004120 putative active site [active] 1415167004121 heme pocket [chemical binding]; other site 1415167004122 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1415167004123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167004124 putative active site [active] 1415167004125 heme pocket [chemical binding]; other site 1415167004126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167004127 dimer interface [polypeptide binding]; other site 1415167004128 phosphorylation site [posttranslational modification] 1415167004129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167004130 ATP binding site [chemical binding]; other site 1415167004131 Mg2+ binding site [ion binding]; other site 1415167004132 G-X-G motif; other site 1415167004133 aminotransferase A; Validated; Region: PRK07683 1415167004134 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167004135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167004136 homodimer interface [polypeptide binding]; other site 1415167004137 catalytic residue [active] 1415167004138 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1415167004139 putative CheA interaction surface; other site 1415167004140 Response regulator receiver domain; Region: Response_reg; pfam00072 1415167004141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167004142 active site 1415167004143 phosphorylation site [posttranslational modification] 1415167004144 intermolecular recognition site; other site 1415167004145 dimerization interface [polypeptide binding]; other site 1415167004146 YkyB-like protein; Region: YkyB; pfam14177 1415167004147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167004148 H+ Antiporter protein; Region: 2A0121; TIGR00900 1415167004149 putative substrate translocation pore; other site 1415167004150 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167004151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1415167004152 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1415167004153 phosphodiesterase YaeI; Provisional; Region: PRK11340 1415167004154 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1415167004155 putative active site [active] 1415167004156 putative metal binding site [ion binding]; other site 1415167004157 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1415167004158 short chain dehydrogenase; Provisional; Region: PRK07677 1415167004159 NAD(P) binding site [chemical binding]; other site 1415167004160 substrate binding site [chemical binding]; other site 1415167004161 homotetramer interface [polypeptide binding]; other site 1415167004162 active site 1415167004163 homodimer interface [polypeptide binding]; other site 1415167004164 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1415167004165 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1415167004166 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1415167004167 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1415167004168 active site 1415167004169 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1415167004170 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1415167004171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 1415167004172 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1415167004173 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1415167004174 FOG: CBS domain [General function prediction only]; Region: COG0517 1415167004175 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1415167004176 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167004177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167004178 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1415167004179 dimerization interface [polypeptide binding]; other site 1415167004180 flavodoxin; Provisional; Region: PRK06703 1415167004181 BNR repeat-like domain; Region: BNR_2; pfam13088 1415167004182 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1415167004183 flavodoxin, short chain; Region: flav_short; TIGR01753 1415167004184 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1415167004185 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1415167004186 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1415167004187 active site 1415167004188 trimer interface [polypeptide binding]; other site 1415167004189 substrate binding site [chemical binding]; other site 1415167004190 CoA binding site [chemical binding]; other site 1415167004191 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1415167004192 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1415167004193 metal binding site [ion binding]; metal-binding site 1415167004194 putative dimer interface [polypeptide binding]; other site 1415167004195 hypothetical protein; Provisional; Region: PRK03094 1415167004196 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1415167004197 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1415167004198 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1415167004199 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1415167004200 dimer interface [polypeptide binding]; other site 1415167004201 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1415167004202 catalytic triad [active] 1415167004203 peroxidatic and resolving cysteines [active] 1415167004204 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1415167004205 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1415167004206 catalytic residues [active] 1415167004207 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1415167004208 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1415167004209 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1415167004210 GTP binding site; other site 1415167004211 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1415167004212 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1415167004213 ATP binding site [chemical binding]; other site 1415167004214 substrate interface [chemical binding]; other site 1415167004215 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1415167004216 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1415167004217 dimer interface [polypeptide binding]; other site 1415167004218 putative functional site; other site 1415167004219 putative MPT binding site; other site 1415167004220 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1415167004221 Walker A motif; other site 1415167004222 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1415167004223 MoaE homodimer interface [polypeptide binding]; other site 1415167004224 MoaD interaction [polypeptide binding]; other site 1415167004225 active site residues [active] 1415167004226 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1415167004227 MoaE interaction surface [polypeptide binding]; other site 1415167004228 MoeB interaction surface [polypeptide binding]; other site 1415167004229 thiocarboxylated glycine; other site 1415167004230 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1415167004231 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1415167004232 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1415167004233 Walker A/P-loop; other site 1415167004234 ATP binding site [chemical binding]; other site 1415167004235 Q-loop/lid; other site 1415167004236 ABC transporter signature motif; other site 1415167004237 Walker B; other site 1415167004238 D-loop; other site 1415167004239 H-loop/switch region; other site 1415167004240 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1415167004241 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1415167004242 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1415167004243 Walker A/P-loop; other site 1415167004244 ATP binding site [chemical binding]; other site 1415167004245 Q-loop/lid; other site 1415167004246 ABC transporter signature motif; other site 1415167004247 Walker B; other site 1415167004248 D-loop; other site 1415167004249 H-loop/switch region; other site 1415167004250 Yip1 domain; Region: Yip1; pfam04893 1415167004251 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1415167004252 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1415167004253 HlyD family secretion protein; Region: HlyD_3; pfam13437 1415167004254 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1415167004255 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1415167004256 Walker A/P-loop; other site 1415167004257 ATP binding site [chemical binding]; other site 1415167004258 Q-loop/lid; other site 1415167004259 ABC transporter signature motif; other site 1415167004260 Walker B; other site 1415167004261 D-loop; other site 1415167004262 H-loop/switch region; other site 1415167004263 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1415167004264 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1415167004265 FtsX-like permease family; Region: FtsX; pfam02687 1415167004266 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1415167004267 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1415167004268 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1415167004269 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1415167004270 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1415167004271 putative substrate binding site [chemical binding]; other site 1415167004272 putative ATP binding site [chemical binding]; other site 1415167004273 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1415167004274 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1415167004275 active site 1415167004276 phosphorylation site [posttranslational modification] 1415167004277 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1415167004278 active site 1415167004279 P-loop; other site 1415167004280 phosphorylation site [posttranslational modification] 1415167004281 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1415167004282 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1415167004283 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1415167004284 Catalytic site [active] 1415167004285 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1415167004286 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1415167004287 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1415167004288 ABC transporter; Region: ABC_tran_2; pfam12848 1415167004289 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1415167004290 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1415167004291 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1415167004292 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1415167004293 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1415167004294 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1415167004295 rod-share determining protein MreBH; Provisional; Region: PRK13929 1415167004296 MreB and similar proteins; Region: MreB_like; cd10225 1415167004297 nucleotide binding site [chemical binding]; other site 1415167004298 Mg binding site [ion binding]; other site 1415167004299 putative protofilament interaction site [polypeptide binding]; other site 1415167004300 RodZ interaction site [polypeptide binding]; other site 1415167004301 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1415167004302 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1415167004303 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1415167004304 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167004305 putative active site [active] 1415167004306 heme pocket [chemical binding]; other site 1415167004307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167004308 dimer interface [polypeptide binding]; other site 1415167004309 phosphorylation site [posttranslational modification] 1415167004310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167004311 ATP binding site [chemical binding]; other site 1415167004312 Mg2+ binding site [ion binding]; other site 1415167004313 G-X-G motif; other site 1415167004314 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1415167004315 putative active site pocket [active] 1415167004316 dimerization interface [polypeptide binding]; other site 1415167004317 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1415167004318 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1415167004319 putative active site pocket [active] 1415167004320 dimerization interface [polypeptide binding]; other site 1415167004321 putative catalytic residue [active] 1415167004322 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1415167004323 TrkA-N domain; Region: TrkA_N; pfam02254 1415167004324 TrkA-C domain; Region: TrkA_C; pfam02080 1415167004325 adenine deaminase; Region: ade; TIGR01178 1415167004326 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1415167004327 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1415167004328 active site 1415167004329 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1415167004330 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1415167004331 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1415167004332 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1415167004333 hypothetical protein; Provisional; Region: PRK13667 1415167004334 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1415167004335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167004336 active site 1415167004337 motif I; other site 1415167004338 motif II; other site 1415167004339 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167004340 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1415167004341 active site 1415167004342 catalytic residues [active] 1415167004343 metal binding site [ion binding]; metal-binding site 1415167004344 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1415167004345 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1415167004346 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1415167004347 TPP-binding site [chemical binding]; other site 1415167004348 tetramer interface [polypeptide binding]; other site 1415167004349 heterodimer interface [polypeptide binding]; other site 1415167004350 phosphorylation loop region [posttranslational modification] 1415167004351 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1415167004352 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1415167004353 alpha subunit interface [polypeptide binding]; other site 1415167004354 TPP binding site [chemical binding]; other site 1415167004355 heterodimer interface [polypeptide binding]; other site 1415167004356 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1415167004357 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1415167004358 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1415167004359 E3 interaction surface; other site 1415167004360 lipoyl attachment site [posttranslational modification]; other site 1415167004361 e3 binding domain; Region: E3_binding; pfam02817 1415167004362 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1415167004363 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1415167004364 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1415167004365 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1415167004366 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1415167004367 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1415167004368 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1415167004369 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1415167004370 homodimer interface [polypeptide binding]; other site 1415167004371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167004372 catalytic residue [active] 1415167004373 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1415167004374 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1415167004375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1415167004376 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1415167004377 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1415167004378 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1415167004379 active site 1415167004380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1415167004381 Coenzyme A binding pocket [chemical binding]; other site 1415167004382 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1415167004383 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1415167004384 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1415167004385 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1415167004386 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1415167004387 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1415167004388 active site 1415167004389 Zn binding site [ion binding]; other site 1415167004390 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167004391 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1415167004392 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167004393 DNA binding residues [nucleotide binding] 1415167004394 Predicted integral membrane protein [Function unknown]; Region: COG5660 1415167004395 Putative zinc-finger; Region: zf-HC2; pfam13490 1415167004396 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1415167004397 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1415167004398 G1 box; other site 1415167004399 putative GEF interaction site [polypeptide binding]; other site 1415167004400 GTP/Mg2+ binding site [chemical binding]; other site 1415167004401 Switch I region; other site 1415167004402 G2 box; other site 1415167004403 G3 box; other site 1415167004404 Switch II region; other site 1415167004405 G4 box; other site 1415167004406 G5 box; other site 1415167004407 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1415167004408 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1415167004409 YlaH-like protein; Region: YlaH; pfam14036 1415167004410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 1415167004411 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1415167004412 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1415167004413 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1415167004414 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1415167004415 putative active site [active] 1415167004416 PhoH-like protein; Region: PhoH; pfam02562 1415167004417 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1415167004418 glutaminase A; Region: Gln_ase; TIGR03814 1415167004419 hypothetical protein; Provisional; Region: PRK13666 1415167004420 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1415167004421 pyruvate carboxylase; Reviewed; Region: PRK12999 1415167004422 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1415167004423 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1415167004424 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1415167004425 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1415167004426 active site 1415167004427 catalytic residues [active] 1415167004428 metal binding site [ion binding]; metal-binding site 1415167004429 homodimer binding site [polypeptide binding]; other site 1415167004430 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1415167004431 carboxyltransferase (CT) interaction site; other site 1415167004432 biotinylation site [posttranslational modification]; other site 1415167004433 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1415167004434 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1415167004435 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1415167004436 UbiA prenyltransferase family; Region: UbiA; pfam01040 1415167004437 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1415167004438 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1415167004439 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 1415167004440 Cytochrome c; Region: Cytochrom_C; pfam00034 1415167004441 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1415167004442 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1415167004443 D-pathway; other site 1415167004444 Putative ubiquinol binding site [chemical binding]; other site 1415167004445 Low-spin heme (heme b) binding site [chemical binding]; other site 1415167004446 Putative water exit pathway; other site 1415167004447 Binuclear center (heme o3/CuB) [ion binding]; other site 1415167004448 K-pathway; other site 1415167004449 Putative proton exit pathway; other site 1415167004450 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1415167004451 Subunit I/III interface [polypeptide binding]; other site 1415167004452 Subunit III/IV interface [polypeptide binding]; other site 1415167004453 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1415167004454 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 1415167004455 YugN-like family; Region: YugN; pfam08868 1415167004456 FOG: CBS domain [General function prediction only]; Region: COG0517 1415167004457 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1415167004458 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1415167004459 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1415167004460 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1415167004461 Putative coat protein; Region: YlbD_coat; pfam14071 1415167004462 YlbE-like protein; Region: YlbE; pfam14003 1415167004463 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1415167004464 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 1415167004465 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1415167004466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167004467 S-adenosylmethionine binding site [chemical binding]; other site 1415167004468 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1415167004469 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1415167004470 active site 1415167004471 (T/H)XGH motif; other site 1415167004472 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1415167004473 Nucleoside recognition; Region: Gate; pfam07670 1415167004474 Nucleoside recognition; Region: Gate; pfam07670 1415167004475 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1415167004476 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1415167004477 nucleophile elbow; other site 1415167004478 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1415167004479 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1415167004480 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1415167004481 protein binding site [polypeptide binding]; other site 1415167004482 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1415167004483 hypothetical protein; Provisional; Region: PRK13670 1415167004484 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1415167004485 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1415167004486 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1415167004487 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1415167004488 hypothetical protein; Provisional; Region: PRK13688 1415167004489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167004490 Coenzyme A binding pocket [chemical binding]; other site 1415167004491 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 1415167004492 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1415167004493 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1415167004494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1415167004495 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1415167004496 mraZ protein; Region: TIGR00242 1415167004497 MraZ protein; Region: MraZ; pfam02381 1415167004498 MraZ protein; Region: MraZ; pfam02381 1415167004499 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1415167004500 MraW methylase family; Region: Methyltransf_5; pfam01795 1415167004501 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1415167004502 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1415167004503 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1415167004504 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1415167004505 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1415167004506 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1415167004507 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1415167004508 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1415167004509 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1415167004510 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1415167004511 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1415167004512 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1415167004513 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1415167004514 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1415167004515 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1415167004516 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1415167004517 Mg++ binding site [ion binding]; other site 1415167004518 putative catalytic motif [active] 1415167004519 putative substrate binding site [chemical binding]; other site 1415167004520 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1415167004521 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1415167004522 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1415167004523 stage V sporulation protein E; Region: spoVE; TIGR02615 1415167004524 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1415167004525 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1415167004526 active site 1415167004527 homodimer interface [polypeptide binding]; other site 1415167004528 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1415167004529 FAD binding domain; Region: FAD_binding_4; pfam01565 1415167004530 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1415167004531 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1415167004532 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1415167004533 Cell division protein FtsQ; Region: FtsQ; pfam03799 1415167004534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1415167004535 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1415167004536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1415167004537 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1415167004538 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 1415167004539 cell division protein FtsA; Region: ftsA; TIGR01174 1415167004540 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1415167004541 nucleotide binding site [chemical binding]; other site 1415167004542 Cell division protein FtsA; Region: FtsA; pfam14450 1415167004543 cell division protein FtsZ; Validated; Region: PRK09330 1415167004544 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1415167004545 nucleotide binding site [chemical binding]; other site 1415167004546 SulA interaction site; other site 1415167004547 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1415167004548 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1415167004549 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1415167004550 active site 1415167004551 catalytic triad [active] 1415167004552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1415167004553 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1415167004554 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1415167004555 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1415167004556 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1415167004557 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1415167004558 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1415167004559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167004560 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167004561 DNA binding residues [nucleotide binding] 1415167004562 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1415167004563 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167004564 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1415167004565 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167004566 DNA binding residues [nucleotide binding] 1415167004567 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1415167004568 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1415167004569 Walker A/P-loop; other site 1415167004570 ATP binding site [chemical binding]; other site 1415167004571 Q-loop/lid; other site 1415167004572 ABC transporter signature motif; other site 1415167004573 Walker B; other site 1415167004574 D-loop; other site 1415167004575 H-loop/switch region; other site 1415167004576 acetylornithine deacetylase; Validated; Region: PRK08596 1415167004577 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1415167004578 metal binding site [ion binding]; metal-binding site 1415167004579 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1415167004580 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1415167004581 uncharacterized protein, YfiH family; Region: TIGR00726 1415167004582 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1415167004583 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1415167004584 catalytic residue [active] 1415167004585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1415167004586 YGGT family; Region: YGGT; pfam02325 1415167004587 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1415167004588 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1415167004589 RNA binding surface [nucleotide binding]; other site 1415167004590 DivIVA protein; Region: DivIVA; pfam05103 1415167004591 DivIVA domain; Region: DivI1A_domain; TIGR03544 1415167004592 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1415167004593 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1415167004594 HIGH motif; other site 1415167004595 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1415167004596 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1415167004597 active site 1415167004598 KMSKS motif; other site 1415167004599 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1415167004600 tRNA binding surface [nucleotide binding]; other site 1415167004601 anticodon binding site; other site 1415167004602 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1415167004603 lipoprotein signal peptidase; Region: lspA; TIGR00077 1415167004604 lipoprotein signal peptidase; Provisional; Region: PRK14787 1415167004605 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1415167004606 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1415167004607 RNA binding surface [nucleotide binding]; other site 1415167004608 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1415167004609 active site 1415167004610 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1415167004611 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1415167004612 active site 1415167004613 uracil-xanthine permease; Region: ncs2; TIGR00801 1415167004614 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1415167004615 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1415167004616 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1415167004617 dihydroorotase; Validated; Region: pyrC; PRK09357 1415167004618 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1415167004619 active site 1415167004620 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1415167004621 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1415167004622 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1415167004623 catalytic site [active] 1415167004624 subunit interface [polypeptide binding]; other site 1415167004625 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1415167004626 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1415167004627 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1415167004628 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1415167004629 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1415167004630 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1415167004631 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1415167004632 IMP binding site; other site 1415167004633 dimer interface [polypeptide binding]; other site 1415167004634 interdomain contacts; other site 1415167004635 partial ornithine binding site; other site 1415167004636 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1415167004637 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1415167004638 FAD binding pocket [chemical binding]; other site 1415167004639 FAD binding motif [chemical binding]; other site 1415167004640 phosphate binding motif [ion binding]; other site 1415167004641 beta-alpha-beta structure motif; other site 1415167004642 NAD binding pocket [chemical binding]; other site 1415167004643 Iron coordination center [ion binding]; other site 1415167004644 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1415167004645 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1415167004646 heterodimer interface [polypeptide binding]; other site 1415167004647 active site 1415167004648 FMN binding site [chemical binding]; other site 1415167004649 homodimer interface [polypeptide binding]; other site 1415167004650 substrate binding site [chemical binding]; other site 1415167004651 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1415167004652 active site 1415167004653 dimer interface [polypeptide binding]; other site 1415167004654 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1415167004655 active site 1415167004656 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1415167004657 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1415167004658 Active Sites [active] 1415167004659 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1415167004660 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1415167004661 ATP-sulfurylase; Region: ATPS; cd00517 1415167004662 active site 1415167004663 HXXH motif; other site 1415167004664 flexible loop; other site 1415167004665 AAA domain; Region: AAA_33; pfam13671 1415167004666 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1415167004667 ligand-binding site [chemical binding]; other site 1415167004668 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1415167004669 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1415167004670 active site 1415167004671 SAM binding site [chemical binding]; other site 1415167004672 homodimer interface [polypeptide binding]; other site 1415167004673 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1415167004674 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1415167004675 putative active site [active] 1415167004676 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1415167004677 putative active site [active] 1415167004678 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1415167004679 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1415167004680 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1415167004681 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1415167004682 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1415167004683 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1415167004684 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1415167004685 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1415167004686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167004687 motif II; other site 1415167004688 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1415167004689 TIGR00255 family protein; Region: TIGR00255 1415167004690 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1415167004691 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1415167004692 hypothetical protein; Provisional; Region: PRK04323 1415167004693 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1415167004694 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1415167004695 catalytic site [active] 1415167004696 G-X2-G-X-G-K; other site 1415167004697 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1415167004698 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1415167004699 Flavoprotein; Region: Flavoprotein; pfam02441 1415167004700 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1415167004701 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1415167004702 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1415167004703 ATP binding site [chemical binding]; other site 1415167004704 putative Mg++ binding site [ion binding]; other site 1415167004705 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167004706 nucleotide binding region [chemical binding]; other site 1415167004707 ATP-binding site [chemical binding]; other site 1415167004708 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1415167004709 active site 1415167004710 catalytic residues [active] 1415167004711 metal binding site [ion binding]; metal-binding site 1415167004712 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1415167004713 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1415167004714 putative active site [active] 1415167004715 substrate binding site [chemical binding]; other site 1415167004716 putative cosubstrate binding site; other site 1415167004717 catalytic site [active] 1415167004718 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1415167004719 substrate binding site [chemical binding]; other site 1415167004720 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1415167004721 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1415167004722 putative RNA binding site [nucleotide binding]; other site 1415167004723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167004724 S-adenosylmethionine binding site [chemical binding]; other site 1415167004725 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1415167004726 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167004727 FeS/SAM binding site; other site 1415167004728 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1415167004729 Protein phosphatase 2C; Region: PP2C; pfam00481 1415167004730 active site 1415167004731 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1415167004732 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1415167004733 active site 1415167004734 ATP binding site [chemical binding]; other site 1415167004735 substrate binding site [chemical binding]; other site 1415167004736 activation loop (A-loop); other site 1415167004737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1415167004738 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1415167004739 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1415167004740 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1415167004741 GTPase RsgA; Reviewed; Region: PRK00098 1415167004742 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1415167004743 RNA binding site [nucleotide binding]; other site 1415167004744 homodimer interface [polypeptide binding]; other site 1415167004745 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1415167004746 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1415167004747 GTP/Mg2+ binding site [chemical binding]; other site 1415167004748 G4 box; other site 1415167004749 G5 box; other site 1415167004750 G1 box; other site 1415167004751 Switch I region; other site 1415167004752 G2 box; other site 1415167004753 G3 box; other site 1415167004754 Switch II region; other site 1415167004755 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1415167004756 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1415167004757 substrate binding site [chemical binding]; other site 1415167004758 hexamer interface [polypeptide binding]; other site 1415167004759 metal binding site [ion binding]; metal-binding site 1415167004760 Thiamine pyrophosphokinase; Region: TPK; cd07995 1415167004761 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1415167004762 active site 1415167004763 dimerization interface [polypeptide binding]; other site 1415167004764 thiamine binding site [chemical binding]; other site 1415167004765 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1415167004766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1415167004767 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1415167004768 DAK2 domain; Region: Dak2; pfam02734 1415167004769 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1415167004770 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1415167004771 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1415167004772 putative L-serine binding site [chemical binding]; other site 1415167004773 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Region: sda_alpha; TIGR00718 1415167004774 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1415167004775 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1415167004776 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1415167004777 generic binding surface II; other site 1415167004778 ssDNA binding site; other site 1415167004779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1415167004780 ATP binding site [chemical binding]; other site 1415167004781 putative Mg++ binding site [ion binding]; other site 1415167004782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167004783 nucleotide binding region [chemical binding]; other site 1415167004784 ATP-binding site [chemical binding]; other site 1415167004785 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1415167004786 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1415167004787 putative phosphate acyltransferase; Provisional; Region: PRK05331 1415167004788 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1415167004789 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1415167004790 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1415167004791 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1415167004792 NAD(P) binding site [chemical binding]; other site 1415167004793 homotetramer interface [polypeptide binding]; other site 1415167004794 homodimer interface [polypeptide binding]; other site 1415167004795 active site 1415167004796 acyl carrier protein; Provisional; Region: acpP; PRK00982 1415167004797 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1415167004798 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1415167004799 dimerization interface [polypeptide binding]; other site 1415167004800 active site 1415167004801 metal binding site [ion binding]; metal-binding site 1415167004802 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1415167004803 dsRNA binding site [nucleotide binding]; other site 1415167004804 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1415167004805 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1415167004806 Walker A/P-loop; other site 1415167004807 ATP binding site [chemical binding]; other site 1415167004808 Q-loop/lid; other site 1415167004809 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1415167004810 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1415167004811 ABC transporter signature motif; other site 1415167004812 Walker B; other site 1415167004813 D-loop; other site 1415167004814 H-loop/switch region; other site 1415167004815 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1415167004816 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1415167004817 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1415167004818 GTP binding site [chemical binding]; other site 1415167004819 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1415167004820 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1415167004821 putative DNA-binding protein; Validated; Region: PRK00118 1415167004822 signal recognition particle protein; Provisional; Region: PRK10867 1415167004823 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1415167004824 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1415167004825 P loop; other site 1415167004826 GTP binding site [chemical binding]; other site 1415167004827 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1415167004828 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1415167004829 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1415167004830 KH domain; Region: KH_4; pfam13083 1415167004831 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1415167004832 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1415167004833 RimM N-terminal domain; Region: RimM; pfam01782 1415167004834 PRC-barrel domain; Region: PRC; pfam05239 1415167004835 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1415167004836 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1415167004837 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1415167004838 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1415167004839 GTP/Mg2+ binding site [chemical binding]; other site 1415167004840 G4 box; other site 1415167004841 G5 box; other site 1415167004842 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1415167004843 G1 box; other site 1415167004844 G1 box; other site 1415167004845 GTP/Mg2+ binding site [chemical binding]; other site 1415167004846 Switch I region; other site 1415167004847 G2 box; other site 1415167004848 G2 box; other site 1415167004849 G3 box; other site 1415167004850 G3 box; other site 1415167004851 Switch II region; other site 1415167004852 Switch II region; other site 1415167004853 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1415167004854 RNA/DNA hybrid binding site [nucleotide binding]; other site 1415167004855 active site 1415167004856 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1415167004857 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1415167004858 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1415167004859 CoA-ligase; Region: Ligase_CoA; pfam00549 1415167004860 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1415167004861 CoA binding domain; Region: CoA_binding; smart00881 1415167004862 CoA-ligase; Region: Ligase_CoA; pfam00549 1415167004863 DNA protecting protein DprA; Region: dprA; TIGR00732 1415167004864 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1415167004865 DNA topoisomerase I; Validated; Region: PRK05582 1415167004866 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1415167004867 active site 1415167004868 interdomain interaction site; other site 1415167004869 putative metal-binding site [ion binding]; other site 1415167004870 nucleotide binding site [chemical binding]; other site 1415167004871 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1415167004872 domain I; other site 1415167004873 DNA binding groove [nucleotide binding] 1415167004874 phosphate binding site [ion binding]; other site 1415167004875 domain II; other site 1415167004876 domain III; other site 1415167004877 nucleotide binding site [chemical binding]; other site 1415167004878 catalytic site [active] 1415167004879 domain IV; other site 1415167004880 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1415167004881 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1415167004882 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1415167004883 Glucose inhibited division protein A; Region: GIDA; pfam01134 1415167004884 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1415167004885 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1415167004886 active site 1415167004887 Int/Topo IB signature motif; other site 1415167004888 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1415167004889 active site 1415167004890 HslU subunit interaction site [polypeptide binding]; other site 1415167004891 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1415167004892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167004893 Walker A motif; other site 1415167004894 ATP binding site [chemical binding]; other site 1415167004895 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1415167004896 Walker B motif; other site 1415167004897 arginine finger; other site 1415167004898 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1415167004899 transcriptional repressor CodY; Validated; Region: PRK04158 1415167004900 CodY GAF-like domain; Region: CodY; pfam06018 1415167004901 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1415167004902 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1415167004903 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1415167004904 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1415167004905 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1415167004906 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1415167004907 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1415167004908 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1415167004909 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1415167004910 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1415167004911 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1415167004912 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1415167004913 MgtE intracellular N domain; Region: MgtE_N; smart00924 1415167004914 FliG C-terminal domain; Region: FliG_C; pfam01706 1415167004915 flagellar assembly protein H; Validated; Region: fliH; PRK06669 1415167004916 Flagellar assembly protein FliH; Region: FliH; pfam02108 1415167004917 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1415167004918 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1415167004919 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1415167004920 Walker A motif/ATP binding site; other site 1415167004921 Walker B motif; other site 1415167004922 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1415167004923 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1415167004924 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1415167004925 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1415167004926 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1415167004927 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1415167004928 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1415167004929 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1415167004930 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1415167004931 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1415167004932 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 1415167004933 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 1415167004934 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1415167004935 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1415167004936 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1415167004937 flagellar motor switch protein; Validated; Region: PRK08119 1415167004938 CheC-like family; Region: CheC; pfam04509 1415167004939 CheC-like family; Region: CheC; pfam04509 1415167004940 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1415167004941 Response regulator receiver domain; Region: Response_reg; pfam00072 1415167004942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167004943 active site 1415167004944 phosphorylation site [posttranslational modification] 1415167004945 intermolecular recognition site; other site 1415167004946 dimerization interface [polypeptide binding]; other site 1415167004947 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 1415167004948 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1415167004949 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1415167004950 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1415167004951 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1415167004952 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1415167004953 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1415167004954 FHIPEP family; Region: FHIPEP; pfam00771 1415167004955 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1415167004956 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1415167004957 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1415167004958 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1415167004959 P-loop; other site 1415167004960 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1415167004961 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1415167004962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167004963 active site 1415167004964 phosphorylation site [posttranslational modification] 1415167004965 intermolecular recognition site; other site 1415167004966 dimerization interface [polypeptide binding]; other site 1415167004967 CheB methylesterase; Region: CheB_methylest; pfam01339 1415167004968 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1415167004969 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1415167004970 putative binding surface; other site 1415167004971 active site 1415167004972 P2 response regulator binding domain; Region: P2; pfam07194 1415167004973 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1415167004974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167004975 ATP binding site [chemical binding]; other site 1415167004976 Mg2+ binding site [ion binding]; other site 1415167004977 G-X-G motif; other site 1415167004978 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1415167004979 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1415167004980 putative CheA interaction surface; other site 1415167004981 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1415167004982 CheC-like family; Region: CheC; pfam04509 1415167004983 CheC-like family; Region: CheC; pfam04509 1415167004984 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1415167004985 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1415167004986 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167004987 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1415167004988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167004989 DNA binding residues [nucleotide binding] 1415167004990 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1415167004991 rRNA interaction site [nucleotide binding]; other site 1415167004992 S8 interaction site; other site 1415167004993 putative laminin-1 binding site; other site 1415167004994 elongation factor Ts; Provisional; Region: tsf; PRK09377 1415167004995 UBA/TS-N domain; Region: UBA; pfam00627 1415167004996 Elongation factor TS; Region: EF_TS; pfam00889 1415167004997 Elongation factor TS; Region: EF_TS; pfam00889 1415167004998 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1415167004999 putative nucleotide binding site [chemical binding]; other site 1415167005000 uridine monophosphate binding site [chemical binding]; other site 1415167005001 homohexameric interface [polypeptide binding]; other site 1415167005002 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1415167005003 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1415167005004 hinge region; other site 1415167005005 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1415167005006 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1415167005007 catalytic residue [active] 1415167005008 putative FPP diphosphate binding site; other site 1415167005009 putative FPP binding hydrophobic cleft; other site 1415167005010 dimer interface [polypeptide binding]; other site 1415167005011 putative IPP diphosphate binding site; other site 1415167005012 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1415167005013 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1415167005014 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1415167005015 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1415167005016 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1415167005017 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1415167005018 RIP metalloprotease RseP; Region: TIGR00054 1415167005019 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1415167005020 active site 1415167005021 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1415167005022 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1415167005023 protein binding site [polypeptide binding]; other site 1415167005024 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1415167005025 putative substrate binding region [chemical binding]; other site 1415167005026 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1415167005027 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1415167005028 dimer interface [polypeptide binding]; other site 1415167005029 motif 1; other site 1415167005030 active site 1415167005031 motif 2; other site 1415167005032 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1415167005033 putative deacylase active site [active] 1415167005034 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1415167005035 active site 1415167005036 motif 3; other site 1415167005037 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1415167005038 anticodon binding site; other site 1415167005039 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1415167005040 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1415167005041 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1415167005042 generic binding surface II; other site 1415167005043 generic binding surface I; other site 1415167005044 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1415167005045 active site 1415167005046 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1415167005047 active site 1415167005048 catalytic site [active] 1415167005049 substrate binding site [chemical binding]; other site 1415167005050 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1415167005051 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1415167005052 Sm and related proteins; Region: Sm_like; cl00259 1415167005053 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1415167005054 putative oligomer interface [polypeptide binding]; other site 1415167005055 putative RNA binding site [nucleotide binding]; other site 1415167005056 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1415167005057 NusA N-terminal domain; Region: NusA_N; pfam08529 1415167005058 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1415167005059 RNA binding site [nucleotide binding]; other site 1415167005060 homodimer interface [polypeptide binding]; other site 1415167005061 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1415167005062 G-X-X-G motif; other site 1415167005063 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1415167005064 G-X-X-G motif; other site 1415167005065 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1415167005066 putative RNA binding cleft [nucleotide binding]; other site 1415167005067 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1415167005068 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1415167005069 translation initiation factor IF-2; Region: IF-2; TIGR00487 1415167005070 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1415167005071 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1415167005072 G1 box; other site 1415167005073 putative GEF interaction site [polypeptide binding]; other site 1415167005074 GTP/Mg2+ binding site [chemical binding]; other site 1415167005075 Switch I region; other site 1415167005076 G2 box; other site 1415167005077 G3 box; other site 1415167005078 Switch II region; other site 1415167005079 G4 box; other site 1415167005080 G5 box; other site 1415167005081 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1415167005082 Translation-initiation factor 2; Region: IF-2; pfam11987 1415167005083 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1415167005084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1415167005085 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1415167005086 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1415167005087 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1415167005088 RNA binding site [nucleotide binding]; other site 1415167005089 active site 1415167005090 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1415167005091 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 1415167005092 active site 1415167005093 Riboflavin kinase; Region: Flavokinase; smart00904 1415167005094 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1415167005095 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1415167005096 RNase E interface [polypeptide binding]; other site 1415167005097 trimer interface [polypeptide binding]; other site 1415167005098 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1415167005099 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1415167005100 RNase E interface [polypeptide binding]; other site 1415167005101 trimer interface [polypeptide binding]; other site 1415167005102 active site 1415167005103 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1415167005104 putative nucleic acid binding region [nucleotide binding]; other site 1415167005105 G-X-X-G motif; other site 1415167005106 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1415167005107 RNA binding site [nucleotide binding]; other site 1415167005108 domain interface; other site 1415167005109 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1415167005110 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1415167005111 NodB motif; other site 1415167005112 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1415167005113 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1415167005114 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1415167005115 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1415167005116 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1415167005117 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1415167005118 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 1415167005119 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1415167005120 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1415167005121 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1415167005122 aspartate kinase I; Reviewed; Region: PRK08210 1415167005123 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1415167005124 putative catalytic residues [active] 1415167005125 putative nucleotide binding site [chemical binding]; other site 1415167005126 putative aspartate binding site [chemical binding]; other site 1415167005127 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1415167005128 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1415167005129 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1415167005130 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1415167005131 dimer interface [polypeptide binding]; other site 1415167005132 active site 1415167005133 catalytic residue [active] 1415167005134 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1415167005135 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1415167005136 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1415167005137 Clp protease; Region: CLP_protease; pfam00574 1415167005138 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1415167005139 active site 1415167005140 YlzJ-like protein; Region: YlzJ; pfam14035 1415167005141 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1415167005142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167005143 DNA-binding site [nucleotide binding]; DNA binding site 1415167005144 UTRA domain; Region: UTRA; pfam07702 1415167005145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167005146 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167005147 putative substrate translocation pore; other site 1415167005148 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1415167005149 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1415167005150 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1415167005151 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1415167005152 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1415167005153 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1415167005154 classical (c) SDRs; Region: SDR_c; cd05233 1415167005155 NAD(P) binding site [chemical binding]; other site 1415167005156 active site 1415167005157 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1415167005158 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1415167005159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167005160 non-specific DNA binding site [nucleotide binding]; other site 1415167005161 salt bridge; other site 1415167005162 sequence-specific DNA binding site [nucleotide binding]; other site 1415167005163 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1415167005164 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1415167005165 competence damage-inducible protein A; Provisional; Region: PRK00549 1415167005166 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1415167005167 putative MPT binding site; other site 1415167005168 competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199 1415167005169 recombinase A; Provisional; Region: recA; PRK09354 1415167005170 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1415167005171 hexamer interface [polypeptide binding]; other site 1415167005172 Walker A motif; other site 1415167005173 ATP binding site [chemical binding]; other site 1415167005174 Walker B motif; other site 1415167005175 Beta-lactamase; Region: Beta-lactamase; pfam00144 1415167005176 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1415167005177 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1415167005178 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1415167005179 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1415167005180 Zn2+ binding site [ion binding]; other site 1415167005181 Mg2+ binding site [ion binding]; other site 1415167005182 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1415167005183 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1415167005184 putative active site [active] 1415167005185 metal binding site [ion binding]; metal-binding site 1415167005186 homodimer binding site [polypeptide binding]; other site 1415167005187 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1415167005188 Threonine dehydrogenase; Region: TDH; cd05281 1415167005189 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 1415167005190 structural Zn binding site [ion binding]; other site 1415167005191 catalytic Zn binding site [ion binding]; other site 1415167005192 tetramer interface [polypeptide binding]; other site 1415167005193 NADP binding site [chemical binding]; other site 1415167005194 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1415167005195 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1415167005196 substrate-cofactor binding pocket; other site 1415167005197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167005198 catalytic residue [active] 1415167005199 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1415167005200 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1415167005201 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167005202 FeS/SAM binding site; other site 1415167005203 TRAM domain; Region: TRAM; pfam01938 1415167005204 Predicted membrane protein [Function unknown]; Region: COG4550 1415167005205 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1415167005206 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1415167005207 MutS domain I; Region: MutS_I; pfam01624 1415167005208 MutS domain II; Region: MutS_II; pfam05188 1415167005209 MutS domain III; Region: MutS_III; pfam05192 1415167005210 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1415167005211 Walker A/P-loop; other site 1415167005212 ATP binding site [chemical binding]; other site 1415167005213 Q-loop/lid; other site 1415167005214 ABC transporter signature motif; other site 1415167005215 Walker B; other site 1415167005216 D-loop; other site 1415167005217 H-loop/switch region; other site 1415167005218 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1415167005219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167005220 ATP binding site [chemical binding]; other site 1415167005221 Mg2+ binding site [ion binding]; other site 1415167005222 G-X-G motif; other site 1415167005223 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1415167005224 ATP binding site [chemical binding]; other site 1415167005225 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1415167005226 Regulatory protein YrvL; Region: YrvL; pfam14184 1415167005227 transcriptional regulator BetI; Validated; Region: PRK00767 1415167005228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167005229 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1415167005230 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1415167005231 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1415167005232 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1415167005233 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1415167005234 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1415167005235 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1415167005236 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1415167005237 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1415167005238 FMN binding site [chemical binding]; other site 1415167005239 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1415167005240 substrate binding site [chemical binding]; other site 1415167005241 putative catalytic residue [active] 1415167005242 acyl carrier protein; Validated; Region: PRK07117 1415167005243 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1415167005244 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1415167005245 dimer interface [polypeptide binding]; other site 1415167005246 active site 1415167005247 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1415167005248 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1415167005249 substrate binding site [chemical binding]; other site 1415167005250 oxyanion hole (OAH) forming residues; other site 1415167005251 trimer interface [polypeptide binding]; other site 1415167005252 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1415167005253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1415167005254 substrate binding site [chemical binding]; other site 1415167005255 oxyanion hole (OAH) forming residues; other site 1415167005256 trimer interface [polypeptide binding]; other site 1415167005257 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 1415167005258 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1415167005259 acyl-activating enzyme (AAE) consensus motif; other site 1415167005260 putative AMP binding site [chemical binding]; other site 1415167005261 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005262 Condensation domain; Region: Condensation; pfam00668 1415167005263 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167005264 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1415167005265 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1415167005266 acyl-activating enzyme (AAE) consensus motif; other site 1415167005267 AMP binding site [chemical binding]; other site 1415167005268 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005269 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1415167005270 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1415167005271 active site 1415167005272 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1415167005273 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1415167005274 KR domain; Region: KR; pfam08659 1415167005275 putative NADP binding site [chemical binding]; other site 1415167005276 active site 1415167005277 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005278 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005279 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1415167005280 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1415167005281 active site 1415167005282 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1415167005283 putative NADP binding site [chemical binding]; other site 1415167005284 active site 1415167005285 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005286 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1415167005287 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1415167005288 active site 1415167005289 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1415167005290 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005291 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1415167005292 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1415167005293 active site 1415167005294 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1415167005295 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1415167005296 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1415167005297 putative NADP binding site [chemical binding]; other site 1415167005298 active site 1415167005299 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005300 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1415167005301 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1415167005302 active site 1415167005303 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1415167005304 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1415167005305 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1415167005306 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1415167005307 active site 1415167005308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1415167005309 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1415167005310 putative NADP binding site [chemical binding]; other site 1415167005311 active site 1415167005312 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005313 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1415167005314 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1415167005315 active site 1415167005316 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1415167005317 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1415167005318 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1415167005319 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1415167005320 active site 1415167005321 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1415167005322 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1415167005323 putative NADP binding site [chemical binding]; other site 1415167005324 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1415167005325 active site 1415167005326 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1415167005327 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005328 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1415167005329 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1415167005330 active site 1415167005331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1415167005332 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1415167005333 putative NADP binding site [chemical binding]; other site 1415167005334 active site 1415167005335 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005336 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1415167005337 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1415167005338 active site 1415167005339 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005340 frameshift (+1) in homopolymer run at nucleotide position 6839 in gene 1415167005341 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1415167005342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167005343 S-adenosylmethionine binding site [chemical binding]; other site 1415167005344 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1415167005345 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1415167005346 active site 1415167005347 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1415167005348 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1415167005349 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1415167005350 active site 1415167005351 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1415167005352 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1415167005353 Cytochrome P450; Region: p450; cl12078 1415167005354 Phage-related replication protein [General function prediction only]; Region: COG4195 1415167005355 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1415167005356 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1415167005357 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1415167005358 YmaF family; Region: YmaF; pfam12788 1415167005359 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1415167005360 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1415167005361 bacterial Hfq-like; Region: Hfq; cd01716 1415167005362 hexamer interface [polypeptide binding]; other site 1415167005363 Sm1 motif; other site 1415167005364 RNA binding site [nucleotide binding]; other site 1415167005365 Sm2 motif; other site 1415167005366 YmzC-like protein; Region: YmzC; pfam14157 1415167005367 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1415167005368 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1415167005369 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1415167005370 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1415167005371 active site 1415167005372 dimer interface [polypeptide binding]; other site 1415167005373 catalytic residues [active] 1415167005374 effector binding site; other site 1415167005375 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1415167005376 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1415167005377 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1415167005378 dimer interface [polypeptide binding]; other site 1415167005379 putative radical transfer pathway; other site 1415167005380 diiron center [ion binding]; other site 1415167005381 tyrosyl radical; other site 1415167005382 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1415167005383 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1415167005384 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1415167005385 active site 1415167005386 metal binding site [ion binding]; metal-binding site 1415167005387 Sporulation related domain; Region: SPOR; pfam05036 1415167005388 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1415167005389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167005390 Walker A motif; other site 1415167005391 ATP binding site [chemical binding]; other site 1415167005392 Walker B motif; other site 1415167005393 arginine finger; other site 1415167005394 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1415167005395 Aluminium resistance protein; Region: Alum_res; pfam06838 1415167005396 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1415167005397 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1415167005398 DNA binding residues [nucleotide binding] 1415167005399 putative dimer interface [polypeptide binding]; other site 1415167005400 glutamine synthetase, type I; Region: GlnA; TIGR00653 1415167005401 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1415167005402 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1415167005403 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1415167005404 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1415167005405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167005406 Coenzyme A binding pocket [chemical binding]; other site 1415167005407 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1415167005408 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1415167005409 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1415167005410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167005411 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1415167005412 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1415167005413 inhibitor binding site; inhibition site 1415167005414 active site 1415167005415 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1415167005416 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1415167005417 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1415167005418 nucleotide binding site [chemical binding]; other site 1415167005419 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1415167005420 xylose isomerase; Provisional; Region: PRK05474 1415167005421 xylose isomerase; Region: xylose_isom_A; TIGR02630 1415167005422 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1415167005423 N- and C-terminal domain interface [polypeptide binding]; other site 1415167005424 D-xylulose kinase; Region: XylB; TIGR01312 1415167005425 active site 1415167005426 MgATP binding site [chemical binding]; other site 1415167005427 catalytic site [active] 1415167005428 metal binding site [ion binding]; metal-binding site 1415167005429 xylulose binding site [chemical binding]; other site 1415167005430 homodimer interface [polypeptide binding]; other site 1415167005431 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1415167005432 Staphylococcal nuclease homologues; Region: SNc; smart00318 1415167005433 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1415167005434 Catalytic site; other site 1415167005435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167005436 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1415167005437 putative substrate translocation pore; other site 1415167005438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167005439 alanine racemase; Region: alr; TIGR00492 1415167005440 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1415167005441 active site 1415167005442 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1415167005443 dimer interface [polypeptide binding]; other site 1415167005444 substrate binding site [chemical binding]; other site 1415167005445 catalytic residues [active] 1415167005446 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1415167005447 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1415167005448 trimer interface [polypeptide binding]; other site 1415167005449 active site 1415167005450 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1415167005451 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1415167005452 dimerization interface [polypeptide binding]; other site 1415167005453 active site 1415167005454 YoqO-like protein; Region: YoqO; pfam14037 1415167005455 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1415167005456 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1415167005457 putative hydrophobic ligand binding site [chemical binding]; other site 1415167005458 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1415167005459 Spore germination protein; Region: Spore_permease; pfam03845 1415167005460 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1415167005461 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1415167005462 YndJ-like protein; Region: YndJ; pfam14158 1415167005463 Phage-related replication protein [General function prediction only]; Region: COG4195 1415167005464 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1415167005465 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1415167005466 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 1415167005467 putative active site [active] 1415167005468 putative Mg binding site [ion binding]; other site 1415167005469 LexA repressor; Validated; Region: PRK00215 1415167005470 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167005471 putative DNA binding site [nucleotide binding]; other site 1415167005472 putative Zn2+ binding site [ion binding]; other site 1415167005473 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1415167005474 Catalytic site [active] 1415167005475 cell division suppressor protein YneA; Provisional; Region: PRK14125 1415167005476 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167005477 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1415167005478 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1415167005479 catalytic residues [active] 1415167005480 catalytic nucleophile [active] 1415167005481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1415167005482 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1415167005483 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1415167005484 TPP-binding site [chemical binding]; other site 1415167005485 dimer interface [polypeptide binding]; other site 1415167005486 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1415167005487 PYR/PP interface [polypeptide binding]; other site 1415167005488 dimer interface [polypeptide binding]; other site 1415167005489 TPP binding site [chemical binding]; other site 1415167005490 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1415167005491 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1415167005492 hypothetical protein; Provisional; Region: PRK01844 1415167005493 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1415167005494 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1415167005495 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1415167005496 Response regulator receiver domain; Region: Response_reg; pfam00072 1415167005497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167005498 active site 1415167005499 phosphorylation site [posttranslational modification] 1415167005500 intermolecular recognition site; other site 1415167005501 dimerization interface [polypeptide binding]; other site 1415167005502 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1415167005503 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1415167005504 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1415167005505 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1415167005506 putative dimer interface [polypeptide binding]; other site 1415167005507 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1415167005508 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1415167005509 aconitate hydratase; Validated; Region: PRK09277 1415167005510 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1415167005511 substrate binding site [chemical binding]; other site 1415167005512 ligand binding site [chemical binding]; other site 1415167005513 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1415167005514 substrate binding site [chemical binding]; other site 1415167005515 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1415167005516 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1415167005517 catalytic residues [active] 1415167005518 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1415167005519 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1415167005520 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1415167005521 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1415167005522 active site 1415167005523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1415167005524 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1415167005525 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1415167005526 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1415167005527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167005528 ATP binding site [chemical binding]; other site 1415167005529 Mg2+ binding site [ion binding]; other site 1415167005530 G-X-G motif; other site 1415167005531 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1415167005532 anchoring element; other site 1415167005533 dimer interface [polypeptide binding]; other site 1415167005534 ATP binding site [chemical binding]; other site 1415167005535 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1415167005536 active site 1415167005537 putative metal-binding site [ion binding]; other site 1415167005538 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1415167005539 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1415167005540 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1415167005541 CAP-like domain; other site 1415167005542 active site 1415167005543 primary dimer interface [polypeptide binding]; other site 1415167005544 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1415167005545 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1415167005546 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1415167005547 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1415167005548 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1415167005549 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1415167005550 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1415167005551 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1415167005552 Cellulose binding domain; Region: CBM_3; pfam00942 1415167005553 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1415167005554 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1415167005555 Predicted membrane protein [Function unknown]; Region: COG2246 1415167005556 GtrA-like protein; Region: GtrA; pfam04138 1415167005557 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1415167005558 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1415167005559 active site 1415167005560 tetramer interface; other site 1415167005561 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1415167005562 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1415167005563 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1415167005564 DHH family; Region: DHH; pfam01368 1415167005565 DHHA1 domain; Region: DHHA1; pfam02272 1415167005566 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1415167005567 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1415167005568 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1415167005569 enoyl-CoA hydratase; Provisional; Region: PRK07657 1415167005570 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1415167005571 substrate binding site [chemical binding]; other site 1415167005572 oxyanion hole (OAH) forming residues; other site 1415167005573 trimer interface [polypeptide binding]; other site 1415167005574 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1415167005575 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1415167005576 active site 1415167005577 catalytic residues [active] 1415167005578 metal binding site [ion binding]; metal-binding site 1415167005579 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1415167005580 carboxyltransferase (CT) interaction site; other site 1415167005581 biotinylation site [posttranslational modification]; other site 1415167005582 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1415167005583 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1415167005584 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1415167005585 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1415167005586 AMP-binding domain protein; Validated; Region: PRK08315 1415167005587 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1415167005588 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1415167005589 acyl-activating enzyme (AAE) consensus motif; other site 1415167005590 putative AMP binding site [chemical binding]; other site 1415167005591 putative active site [active] 1415167005592 putative CoA binding site [chemical binding]; other site 1415167005593 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1415167005594 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1415167005595 active site 1415167005596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1415167005597 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1415167005598 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1415167005599 Condensation domain; Region: Condensation; pfam00668 1415167005600 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167005601 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1415167005602 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1415167005603 acyl-activating enzyme (AAE) consensus motif; other site 1415167005604 AMP binding site [chemical binding]; other site 1415167005605 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005606 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1415167005607 Condensation domain; Region: Condensation; pfam00668 1415167005608 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167005609 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1415167005610 acyl-activating enzyme (AAE) consensus motif; other site 1415167005611 AMP binding site [chemical binding]; other site 1415167005612 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005613 Condensation domain; Region: Condensation; pfam00668 1415167005614 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167005615 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1415167005616 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1415167005617 acyl-activating enzyme (AAE) consensus motif; other site 1415167005618 AMP binding site [chemical binding]; other site 1415167005619 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005620 Condensation domain; Region: Condensation; pfam00668 1415167005621 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167005622 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1415167005623 Condensation domain; Region: Condensation; pfam00668 1415167005624 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167005625 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1415167005626 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1415167005627 acyl-activating enzyme (AAE) consensus motif; other site 1415167005628 AMP binding site [chemical binding]; other site 1415167005629 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005630 Condensation domain; Region: Condensation; pfam00668 1415167005631 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167005632 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1415167005633 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1415167005634 acyl-activating enzyme (AAE) consensus motif; other site 1415167005635 AMP binding site [chemical binding]; other site 1415167005636 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167005637 Condensation domain; Region: Condensation; pfam00668 1415167005638 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167005639 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1415167005640 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1415167005641 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1415167005642 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1415167005643 active site 1415167005644 catalytic residues [active] 1415167005645 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1415167005646 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1415167005647 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1415167005648 Int/Topo IB signature motif; other site 1415167005649 Helix-turn-helix domain; Region: HTH_17; cl17695 1415167005650 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1415167005651 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1415167005652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167005653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167005654 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1415167005655 putative dimerization interface [polypeptide binding]; other site 1415167005656 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1415167005657 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1415167005658 NAD(P) binding site [chemical binding]; other site 1415167005659 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1415167005660 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1415167005661 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1415167005662 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1415167005663 active site 1415167005664 dimer interface [polypeptide binding]; other site 1415167005665 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1415167005666 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1415167005667 active site 1415167005668 FMN binding site [chemical binding]; other site 1415167005669 substrate binding site [chemical binding]; other site 1415167005670 3Fe-4S cluster binding site [ion binding]; other site 1415167005671 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1415167005672 domain interface; other site 1415167005673 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167005674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167005675 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1415167005676 putative dimerization interface [polypeptide binding]; other site 1415167005677 gamma-glutamyl kinase; Provisional; Region: PRK13402 1415167005678 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1415167005679 nucleotide binding site [chemical binding]; other site 1415167005680 homotetrameric interface [polypeptide binding]; other site 1415167005681 putative phosphate binding site [ion binding]; other site 1415167005682 putative allosteric binding site; other site 1415167005683 PUA domain; Region: PUA; pfam01472 1415167005684 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1415167005685 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1415167005686 Replication terminator protein; Region: RTP; pfam02334 1415167005687 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1415167005688 classical (c) SDRs; Region: SDR_c; cd05233 1415167005689 NAD(P) binding site [chemical binding]; other site 1415167005690 active site 1415167005691 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1415167005692 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1415167005693 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1415167005694 polyol permease family; Region: 2A0118; TIGR00897 1415167005695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167005696 putative substrate translocation pore; other site 1415167005697 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1415167005698 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 1415167005699 putative N- and C-terminal domain interface [polypeptide binding]; other site 1415167005700 putative active site [active] 1415167005701 putative MgATP binding site [chemical binding]; other site 1415167005702 catalytic site [active] 1415167005703 metal binding site [ion binding]; metal-binding site 1415167005704 carbohydrate binding site [chemical binding]; other site 1415167005705 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1415167005706 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1415167005707 putative ligand binding site [chemical binding]; other site 1415167005708 putative NAD binding site [chemical binding]; other site 1415167005709 catalytic site [active] 1415167005710 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1415167005711 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1415167005712 putative [4Fe-4S] binding site [ion binding]; other site 1415167005713 putative molybdopterin cofactor binding site [chemical binding]; other site 1415167005714 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1415167005715 putative molybdopterin cofactor binding site; other site 1415167005716 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1415167005717 CHASE3 domain; Region: CHASE3; cl05000 1415167005718 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167005719 dimerization interface [polypeptide binding]; other site 1415167005720 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1415167005721 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1415167005722 dimer interface [polypeptide binding]; other site 1415167005723 putative CheW interface [polypeptide binding]; other site 1415167005724 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1415167005725 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1415167005726 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 1415167005727 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1415167005728 Predicted membrane protein [Function unknown]; Region: COG3619 1415167005729 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1415167005730 Amb_all domain; Region: Amb_all; smart00656 1415167005731 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1415167005732 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1415167005733 Cupin; Region: Cupin_1; smart00835 1415167005734 Cupin; Region: Cupin_1; smart00835 1415167005735 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1415167005736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167005737 Coenzyme A binding pocket [chemical binding]; other site 1415167005738 YoaP-like; Region: YoaP; pfam14268 1415167005739 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1415167005740 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1415167005741 VanW like protein; Region: VanW; pfam04294 1415167005742 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1415167005743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167005744 salt bridge; other site 1415167005745 non-specific DNA binding site [nucleotide binding]; other site 1415167005746 sequence-specific DNA binding site [nucleotide binding]; other site 1415167005747 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 1415167005748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167005749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167005750 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1415167005751 dimerization interface [polypeptide binding]; other site 1415167005752 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1415167005753 EamA-like transporter family; Region: EamA; pfam00892 1415167005754 EamA-like transporter family; Region: EamA; pfam00892 1415167005755 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1415167005756 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1415167005757 conserved cys residue [active] 1415167005758 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1415167005759 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1415167005760 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 1415167005761 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1415167005762 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1415167005763 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1415167005764 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1415167005765 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1415167005766 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167005767 sequence-specific DNA binding site [nucleotide binding]; other site 1415167005768 salt bridge; other site 1415167005769 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1415167005770 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1415167005771 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1415167005772 putative active site [active] 1415167005773 Bacteriophage holin; Region: Phage_holin_1; pfam04531 1415167005774 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1415167005775 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1415167005776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167005777 TPR motif; other site 1415167005778 binding surface 1415167005779 Y-family of DNA polymerases; Region: PolY; cl12025 1415167005780 DNA binding site [nucleotide binding] 1415167005781 YolD-like protein; Region: YolD; pfam08863 1415167005782 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1415167005783 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1415167005784 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1415167005785 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1415167005786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1415167005787 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1415167005788 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1415167005789 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1415167005790 dimer interface [polypeptide binding]; other site 1415167005791 putative tRNA-binding site [nucleotide binding]; other site 1415167005792 Cupin domain; Region: Cupin_2; pfam07883 1415167005793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167005794 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1415167005795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167005796 Coenzyme A binding pocket [chemical binding]; other site 1415167005797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167005798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167005799 WHG domain; Region: WHG; pfam13305 1415167005800 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1415167005801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1415167005802 Predicted transcriptional regulator [Transcription]; Region: COG2378 1415167005803 HTH domain; Region: HTH_11; pfam08279 1415167005804 WYL domain; Region: WYL; pfam13280 1415167005805 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167005806 dimerization interface [polypeptide binding]; other site 1415167005807 putative DNA binding site [nucleotide binding]; other site 1415167005808 putative Zn2+ binding site [ion binding]; other site 1415167005809 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1415167005810 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1415167005811 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1415167005812 catalytic residue [active] 1415167005813 Predicted membrane protein [Function unknown]; Region: COG2322 1415167005814 Protein required for attachment to host cells; Region: Host_attach; cl02398 1415167005815 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1415167005816 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1415167005817 putative dimer interface [polypeptide binding]; other site 1415167005818 catalytic triad [active] 1415167005819 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1415167005820 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1415167005821 putative di-iron ligands [ion binding]; other site 1415167005822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1415167005823 Histidine kinase; Region: HisKA_3; pfam07730 1415167005824 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1415167005825 ATP binding site [chemical binding]; other site 1415167005826 Mg2+ binding site [ion binding]; other site 1415167005827 G-X-G motif; other site 1415167005828 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1415167005829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167005830 active site 1415167005831 phosphorylation site [posttranslational modification] 1415167005832 intermolecular recognition site; other site 1415167005833 dimerization interface [polypeptide binding]; other site 1415167005834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1415167005835 DNA binding residues [nucleotide binding] 1415167005836 dimerization interface [polypeptide binding]; other site 1415167005837 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167005838 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167005839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1415167005840 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1415167005841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1415167005842 ATP binding site [chemical binding]; other site 1415167005843 putative Mg++ binding site [ion binding]; other site 1415167005844 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167005845 nucleotide binding region [chemical binding]; other site 1415167005846 ATP-binding site [chemical binding]; other site 1415167005847 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1415167005848 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1415167005849 azoreductase; Provisional; Region: PRK13556 1415167005850 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1415167005851 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1415167005852 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1415167005853 putative dimer interface [polypeptide binding]; other site 1415167005854 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1415167005855 pentamer interface [polypeptide binding]; other site 1415167005856 dodecaamer interface [polypeptide binding]; other site 1415167005857 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1415167005858 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1415167005859 NAD(P) binding site [chemical binding]; other site 1415167005860 catalytic residues [active] 1415167005861 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1415167005862 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1415167005863 Active site cavity [active] 1415167005864 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1415167005865 catalytic acid [active] 1415167005866 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1415167005867 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1415167005868 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1415167005869 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1415167005870 Na2 binding site [ion binding]; other site 1415167005871 putative substrate binding site 1 [chemical binding]; other site 1415167005872 Na binding site 1 [ion binding]; other site 1415167005873 putative substrate binding site 2 [chemical binding]; other site 1415167005874 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1415167005875 Sodium Bile acid symporter family; Region: SBF; pfam01758 1415167005876 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1415167005877 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1415167005878 E3 interaction surface; other site 1415167005879 lipoyl attachment site [posttranslational modification]; other site 1415167005880 e3 binding domain; Region: E3_binding; pfam02817 1415167005881 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1415167005882 2-oxoglutarate dehydrogenase, E1 component; Region: 2oxo_dh_E1; TIGR00239 1415167005883 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1415167005884 TPP-binding site [chemical binding]; other site 1415167005885 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1415167005886 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1415167005887 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1415167005888 metal ion-dependent adhesion site (MIDAS); other site 1415167005889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167005890 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1415167005891 Walker A motif; other site 1415167005892 ATP binding site [chemical binding]; other site 1415167005893 Walker B motif; other site 1415167005894 arginine finger; other site 1415167005895 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1415167005896 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1415167005897 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1415167005898 E-class dimer interface [polypeptide binding]; other site 1415167005899 P-class dimer interface [polypeptide binding]; other site 1415167005900 active site 1415167005901 Cu2+ binding site [ion binding]; other site 1415167005902 Zn2+ binding site [ion binding]; other site 1415167005903 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167005904 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167005905 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167005906 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167005907 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1415167005908 NlpC/P60 family; Region: NLPC_P60; pfam00877 1415167005909 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1415167005910 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1415167005911 active site 1415167005912 TDP-binding site; other site 1415167005913 acceptor substrate-binding pocket; other site 1415167005914 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1415167005915 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1415167005916 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1415167005917 multidrug efflux protein; Reviewed; Region: PRK01766 1415167005918 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1415167005919 cation binding site [ion binding]; other site 1415167005920 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1415167005921 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1415167005922 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1415167005923 rarD protein; Region: rarD; TIGR00688 1415167005924 EamA-like transporter family; Region: EamA; pfam00892 1415167005925 GntP family permease; Region: GntP_permease; pfam02447 1415167005926 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1415167005927 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1415167005928 Predicted transcriptional regulators [Transcription]; Region: COG1733 1415167005929 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167005930 dimerization interface [polypeptide binding]; other site 1415167005931 putative DNA binding site [nucleotide binding]; other site 1415167005932 putative Zn2+ binding site [ion binding]; other site 1415167005933 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1415167005934 dimer interface [polypeptide binding]; other site 1415167005935 FMN binding site [chemical binding]; other site 1415167005936 Predicted esterase [General function prediction only]; Region: COG0400 1415167005937 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1415167005938 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167005939 Zn binding site [ion binding]; other site 1415167005940 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1415167005941 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167005942 Zn binding site [ion binding]; other site 1415167005943 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1415167005944 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1415167005945 Na binding site [ion binding]; other site 1415167005946 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1415167005947 C-terminal peptidase (prc); Region: prc; TIGR00225 1415167005948 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1415167005949 protein binding site [polypeptide binding]; other site 1415167005950 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1415167005951 Catalytic dyad [active] 1415167005952 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1415167005953 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1415167005954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167005955 S-adenosylmethionine binding site [chemical binding]; other site 1415167005956 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1415167005957 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1415167005958 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1415167005959 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1415167005960 YodL-like; Region: YodL; pfam14191 1415167005961 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1415167005962 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1415167005963 active site 1415167005964 YozD-like protein; Region: YozD; pfam14162 1415167005965 hypothetical protein; Provisional; Region: PRK13672 1415167005966 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1415167005967 toxin interface [polypeptide binding]; other site 1415167005968 Zn binding site [ion binding]; other site 1415167005969 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1415167005970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167005971 FeS/SAM binding site; other site 1415167005972 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1415167005973 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1415167005974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167005975 Coenzyme A binding pocket [chemical binding]; other site 1415167005976 acetylornithine deacetylase; Validated; Region: PRK06915 1415167005977 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1415167005978 metal binding site [ion binding]; metal-binding site 1415167005979 dimer interface [polypeptide binding]; other site 1415167005980 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1415167005981 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1415167005982 hypothetical protein; Provisional; Region: PRK06917 1415167005983 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1415167005984 inhibitor-cofactor binding pocket; inhibition site 1415167005985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167005986 catalytic residue [active] 1415167005987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167005988 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1415167005989 Coenzyme A binding pocket [chemical binding]; other site 1415167005990 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1415167005991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1415167005992 active site 1415167005993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1415167005994 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1415167005995 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1415167005996 Phytase; Region: Phytase; pfam02333 1415167005997 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1415167005998 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1415167005999 NAD(P) binding site [chemical binding]; other site 1415167006000 homodimer interface [polypeptide binding]; other site 1415167006001 substrate binding site [chemical binding]; other site 1415167006002 active site 1415167006003 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1415167006004 SelR domain; Region: SelR; pfam01641 1415167006005 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1415167006006 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167006007 MarR family; Region: MarR; pfam01047 1415167006008 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1415167006009 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1415167006010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 1415167006011 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1415167006012 active site 1415167006013 catalytic triad [active] 1415167006014 oxyanion hole [active] 1415167006015 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1415167006016 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1415167006017 Cu(I) binding site [ion binding]; other site 1415167006018 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1415167006019 threonine dehydratase; Validated; Region: PRK08639 1415167006020 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1415167006021 tetramer interface [polypeptide binding]; other site 1415167006022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167006023 catalytic residue [active] 1415167006024 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1415167006025 putative Ile/Val binding site [chemical binding]; other site 1415167006026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167006027 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1415167006028 Walker A motif; other site 1415167006029 ATP binding site [chemical binding]; other site 1415167006030 Walker B motif; other site 1415167006031 arginine finger; other site 1415167006032 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1415167006033 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1415167006034 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1415167006035 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1415167006036 putative acyl-acceptor binding pocket; other site 1415167006037 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1415167006038 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1415167006039 folate binding site [chemical binding]; other site 1415167006040 NADP+ binding site [chemical binding]; other site 1415167006041 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1415167006042 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1415167006043 dimerization interface [polypeptide binding]; other site 1415167006044 active site 1415167006045 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1415167006046 tetramer interfaces [polypeptide binding]; other site 1415167006047 binuclear metal-binding site [ion binding]; other site 1415167006048 YpjP-like protein; Region: YpjP; pfam14005 1415167006049 ribosomal biogenesis protein; Validated; Region: PRK00933 1415167006050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167006051 S-adenosylmethionine binding site [chemical binding]; other site 1415167006052 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1415167006053 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1415167006054 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1415167006055 Virulence factor; Region: Virulence_fact; pfam13769 1415167006056 HEAT repeats; Region: HEAT_2; pfam13646 1415167006057 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1415167006058 HEAT repeats; Region: HEAT_2; pfam13646 1415167006059 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1415167006060 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1415167006061 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1415167006062 Zn2+ binding site [ion binding]; other site 1415167006063 Mg2+ binding site [ion binding]; other site 1415167006064 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1415167006065 catalytic residues [active] 1415167006066 dimer interface [polypeptide binding]; other site 1415167006067 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1415167006068 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1415167006069 proposed active site lysine [active] 1415167006070 conserved cys residue [active] 1415167006071 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1415167006072 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1415167006073 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1415167006074 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1415167006075 DNA-binding site [nucleotide binding]; DNA binding site 1415167006076 RNA-binding motif; other site 1415167006077 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1415167006078 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1415167006079 hypothetical protein; Validated; Region: PRK07708 1415167006080 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1415167006081 RNA/DNA hybrid binding site [nucleotide binding]; other site 1415167006082 active site 1415167006083 conserved hypothetical integral membrane protein; Region: TIGR00697 1415167006084 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1415167006085 RNA/DNA hybrid binding site [nucleotide binding]; other site 1415167006086 active site 1415167006087 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1415167006088 5'-3' exonuclease; Region: 53EXOc; smart00475 1415167006089 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1415167006090 active site 1415167006091 metal binding site 1 [ion binding]; metal-binding site 1415167006092 putative 5' ssDNA interaction site; other site 1415167006093 metal binding site 3; metal-binding site 1415167006094 metal binding site 2 [ion binding]; metal-binding site 1415167006095 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1415167006096 putative DNA binding site [nucleotide binding]; other site 1415167006097 putative metal binding site [ion binding]; other site 1415167006098 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1415167006099 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1415167006100 Dynamin family; Region: Dynamin_N; pfam00350 1415167006101 G1 box; other site 1415167006102 GTP/Mg2+ binding site [chemical binding]; other site 1415167006103 G2 box; other site 1415167006104 Switch I region; other site 1415167006105 G3 box; other site 1415167006106 Switch II region; other site 1415167006107 G4 box; other site 1415167006108 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1415167006109 G1 box; other site 1415167006110 GTP/Mg2+ binding site [chemical binding]; other site 1415167006111 Dynamin family; Region: Dynamin_N; pfam00350 1415167006112 G2 box; other site 1415167006113 Switch I region; other site 1415167006114 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1415167006115 G3 box; other site 1415167006116 Switch II region; other site 1415167006117 GTP/Mg2+ binding site [chemical binding]; other site 1415167006118 G4 box; other site 1415167006119 G5 box; other site 1415167006120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1415167006121 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1415167006122 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1415167006123 malonyl-CoA binding site [chemical binding]; other site 1415167006124 dimer interface [polypeptide binding]; other site 1415167006125 active site 1415167006126 product binding site; other site 1415167006127 xanthine permease; Region: pbuX; TIGR03173 1415167006128 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1415167006129 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1415167006130 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1415167006131 active site 1415167006132 Zn binding site [ion binding]; other site 1415167006133 2-keto-3-deoxygluconate permease; Region: KdgT; pfam03812 1415167006134 Entner-Doudoroff aldolase; Region: eda; TIGR01182 1415167006135 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1415167006136 active site 1415167006137 intersubunit interface [polypeptide binding]; other site 1415167006138 catalytic residue [active] 1415167006139 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1415167006140 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1415167006141 substrate binding site [chemical binding]; other site 1415167006142 ATP binding site [chemical binding]; other site 1415167006143 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1415167006144 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1415167006145 DNA binding site [nucleotide binding] 1415167006146 domain linker motif; other site 1415167006147 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1415167006148 putative dimerization interface [polypeptide binding]; other site 1415167006149 putative ligand binding site [chemical binding]; other site 1415167006150 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1415167006151 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1415167006152 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1415167006153 NADP binding site [chemical binding]; other site 1415167006154 homodimer interface [polypeptide binding]; other site 1415167006155 active site 1415167006156 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1415167006157 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1415167006158 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1415167006159 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1415167006160 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1415167006161 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1415167006162 cell division protein GpsB; Provisional; Region: PRK14127 1415167006163 DivIVA domain; Region: DivI1A_domain; TIGR03544 1415167006164 hypothetical protein; Provisional; Region: PRK13660 1415167006165 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1415167006166 RNase_H superfamily; Region: RNase_H_2; pfam13482 1415167006167 active site 1415167006168 substrate binding site [chemical binding]; other site 1415167006169 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1415167006170 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1415167006171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1415167006172 ATP binding site [chemical binding]; other site 1415167006173 putative Mg++ binding site [ion binding]; other site 1415167006174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167006175 nucleotide binding region [chemical binding]; other site 1415167006176 ATP-binding site [chemical binding]; other site 1415167006177 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1415167006178 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1415167006179 HPr interaction site; other site 1415167006180 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1415167006181 active site 1415167006182 phosphorylation site [posttranslational modification] 1415167006183 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1415167006184 YppG-like protein; Region: YppG; pfam14179 1415167006185 YppF-like protein; Region: YppF; pfam14178 1415167006186 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1415167006187 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1415167006188 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1415167006189 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1415167006190 Transglycosylase; Region: Transgly; pfam00912 1415167006191 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1415167006192 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1415167006193 Interdomain contacts; other site 1415167006194 Cytokine receptor motif; other site 1415167006195 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1415167006196 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1415167006197 minor groove reading motif; other site 1415167006198 helix-hairpin-helix signature motif; other site 1415167006199 substrate binding pocket [chemical binding]; other site 1415167006200 active site 1415167006201 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1415167006202 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1415167006203 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1415167006204 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1415167006205 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1415167006206 putative dimer interface [polypeptide binding]; other site 1415167006207 putative anticodon binding site; other site 1415167006208 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1415167006209 homodimer interface [polypeptide binding]; other site 1415167006210 motif 1; other site 1415167006211 motif 2; other site 1415167006212 active site 1415167006213 motif 3; other site 1415167006214 aspartate aminotransferase; Provisional; Region: PRK05764 1415167006215 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167006216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167006217 homodimer interface [polypeptide binding]; other site 1415167006218 catalytic residue [active] 1415167006219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1415167006220 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1415167006221 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1415167006222 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1415167006223 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1415167006224 active site 1415167006225 catalytic site [active] 1415167006226 substrate binding site [chemical binding]; other site 1415167006227 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1415167006228 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1415167006229 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1415167006230 tetramerization interface [polypeptide binding]; other site 1415167006231 active site 1415167006232 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1415167006233 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1415167006234 active site 1415167006235 ATP-binding site [chemical binding]; other site 1415167006236 pantoate-binding site; other site 1415167006237 HXXH motif; other site 1415167006238 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1415167006239 oligomerization interface [polypeptide binding]; other site 1415167006240 active site 1415167006241 metal binding site [ion binding]; metal-binding site 1415167006242 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1415167006243 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1415167006244 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1415167006245 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1415167006246 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1415167006247 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1415167006248 active site 1415167006249 NTP binding site [chemical binding]; other site 1415167006250 metal binding triad [ion binding]; metal-binding site 1415167006251 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1415167006252 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1415167006253 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1415167006254 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1415167006255 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1415167006256 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1415167006257 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1415167006258 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1415167006259 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1415167006260 homodimer interface [polypeptide binding]; other site 1415167006261 metal binding site [ion binding]; metal-binding site 1415167006262 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1415167006263 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167006264 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167006265 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1415167006266 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 1415167006267 Predicted membrane protein [Function unknown]; Region: COG4347 1415167006268 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1415167006269 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1415167006270 intrachain domain interface; other site 1415167006271 Qi binding site; other site 1415167006272 Qo binding site; other site 1415167006273 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1415167006274 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1415167006275 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1415167006276 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1415167006277 interchain domain interface [polypeptide binding]; other site 1415167006278 intrachain domain interface; other site 1415167006279 heme bH binding site [chemical binding]; other site 1415167006280 Qi binding site; other site 1415167006281 heme bL binding site [chemical binding]; other site 1415167006282 Qo binding site; other site 1415167006283 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1415167006284 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1415167006285 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1415167006286 iron-sulfur cluster [ion binding]; other site 1415167006287 [2Fe-2S] cluster binding site [ion binding]; other site 1415167006288 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1415167006289 hypothetical protein; Provisional; Region: PRK03636 1415167006290 UPF0302 domain; Region: UPF0302; pfam08864 1415167006291 IDEAL domain; Region: IDEAL; pfam08858 1415167006292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1415167006293 TPR motif; other site 1415167006294 binding surface 1415167006295 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167006296 binding surface 1415167006297 TPR motif; other site 1415167006298 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1415167006299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167006300 TPR motif; other site 1415167006301 binding surface 1415167006302 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1415167006303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167006304 binding surface 1415167006305 TPR motif; other site 1415167006306 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1415167006307 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1415167006308 hinge; other site 1415167006309 active site 1415167006310 prephenate dehydrogenase; Validated; Region: PRK06545 1415167006311 prephenate dehydrogenase; Validated; Region: PRK08507 1415167006312 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1415167006313 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1415167006314 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167006315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167006316 homodimer interface [polypeptide binding]; other site 1415167006317 catalytic residue [active] 1415167006318 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1415167006319 substrate binding site [chemical binding]; other site 1415167006320 active site 1415167006321 catalytic residues [active] 1415167006322 heterodimer interface [polypeptide binding]; other site 1415167006323 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1415167006324 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1415167006325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167006326 catalytic residue [active] 1415167006327 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1415167006328 active site 1415167006329 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1415167006330 active site 1415167006331 ribulose/triose binding site [chemical binding]; other site 1415167006332 phosphate binding site [ion binding]; other site 1415167006333 substrate (anthranilate) binding pocket [chemical binding]; other site 1415167006334 product (indole) binding pocket [chemical binding]; other site 1415167006335 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1415167006336 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1415167006337 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1415167006338 anthranilate synthase component I; Provisional; Region: PRK13569 1415167006339 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1415167006340 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1415167006341 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1415167006342 homotrimer interaction site [polypeptide binding]; other site 1415167006343 active site 1415167006344 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1415167006345 active site 1415167006346 dimer interface [polypeptide binding]; other site 1415167006347 metal binding site [ion binding]; metal-binding site 1415167006348 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1415167006349 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1415167006350 Tetramer interface [polypeptide binding]; other site 1415167006351 active site 1415167006352 FMN-binding site [chemical binding]; other site 1415167006353 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1415167006354 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1415167006355 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1415167006356 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1415167006357 active site 1415167006358 multimer interface [polypeptide binding]; other site 1415167006359 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1415167006360 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1415167006361 substrate binding pocket [chemical binding]; other site 1415167006362 chain length determination region; other site 1415167006363 substrate-Mg2+ binding site; other site 1415167006364 catalytic residues [active] 1415167006365 aspartate-rich region 1; other site 1415167006366 active site lid residues [active] 1415167006367 aspartate-rich region 2; other site 1415167006368 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1415167006369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167006370 S-adenosylmethionine binding site [chemical binding]; other site 1415167006371 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1415167006372 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1415167006373 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1415167006374 homodecamer interface [polypeptide binding]; other site 1415167006375 GTP cyclohydrolase I; Provisional; Region: PLN03044 1415167006376 active site 1415167006377 putative catalytic site residues [active] 1415167006378 zinc binding site [ion binding]; other site 1415167006379 GTP-CH-I/GFRP interaction surface; other site 1415167006380 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1415167006381 IHF dimer interface [polypeptide binding]; other site 1415167006382 IHF - DNA interface [nucleotide binding]; other site 1415167006383 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1415167006384 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1415167006385 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1415167006386 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1415167006387 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1415167006388 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1415167006389 GTP-binding protein Der; Reviewed; Region: PRK00093 1415167006390 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1415167006391 G1 box; other site 1415167006392 GTP/Mg2+ binding site [chemical binding]; other site 1415167006393 Switch I region; other site 1415167006394 G2 box; other site 1415167006395 Switch II region; other site 1415167006396 G3 box; other site 1415167006397 G4 box; other site 1415167006398 G5 box; other site 1415167006399 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1415167006400 G1 box; other site 1415167006401 GTP/Mg2+ binding site [chemical binding]; other site 1415167006402 Switch I region; other site 1415167006403 G2 box; other site 1415167006404 G3 box; other site 1415167006405 Switch II region; other site 1415167006406 G4 box; other site 1415167006407 G5 box; other site 1415167006408 YIEGIA protein; Region: YIEGIA; pfam14045 1415167006409 YpzI-like protein; Region: YpzI; pfam14140 1415167006410 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1415167006411 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1415167006412 homotetramer interface [polypeptide binding]; other site 1415167006413 FMN binding site [chemical binding]; other site 1415167006414 homodimer contacts [polypeptide binding]; other site 1415167006415 putative active site [active] 1415167006416 putative substrate binding site [chemical binding]; other site 1415167006417 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1415167006418 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1415167006419 RNA binding site [nucleotide binding]; other site 1415167006420 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1415167006421 RNA binding site [nucleotide binding]; other site 1415167006422 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1415167006423 RNA binding site [nucleotide binding]; other site 1415167006424 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1415167006425 RNA binding site [nucleotide binding]; other site 1415167006426 cytidylate kinase; Provisional; Region: cmk; PRK00023 1415167006427 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1415167006428 CMP-binding site; other site 1415167006429 The sites determining sugar specificity; other site 1415167006430 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1415167006431 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1415167006432 PilZ domain; Region: PilZ; pfam07238 1415167006433 germination protein YpeB; Region: spore_YpeB; TIGR02889 1415167006434 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1415167006435 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1415167006436 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1415167006437 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1415167006438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1415167006439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1415167006440 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1415167006441 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1415167006442 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1415167006443 NAD(P) binding site [chemical binding]; other site 1415167006444 adaptor protein; Provisional; Region: PRK02899 1415167006445 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1415167006446 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1415167006447 putative active site [active] 1415167006448 putative metal binding site [ion binding]; other site 1415167006449 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1415167006450 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167006451 CAAX protease self-immunity; Region: Abi; pfam02517 1415167006452 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1415167006453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1415167006454 ATP binding site [chemical binding]; other site 1415167006455 putative Mg++ binding site [ion binding]; other site 1415167006456 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167006457 nucleotide binding region [chemical binding]; other site 1415167006458 ATP-binding site [chemical binding]; other site 1415167006459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1415167006460 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1415167006461 Predicted membrane protein [Function unknown]; Region: COG3601 1415167006462 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1415167006463 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1415167006464 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1415167006465 ligand binding site [chemical binding]; other site 1415167006466 NAD binding site [chemical binding]; other site 1415167006467 dimerization interface [polypeptide binding]; other site 1415167006468 catalytic site [active] 1415167006469 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1415167006470 putative L-serine binding site [chemical binding]; other site 1415167006471 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1415167006472 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1415167006473 active site 1415167006474 catalytic residue [active] 1415167006475 dimer interface [polypeptide binding]; other site 1415167006476 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1415167006477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167006478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167006479 DNA binding residues [nucleotide binding] 1415167006480 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1415167006481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167006482 dimerization interface [polypeptide binding]; other site 1415167006483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167006484 putative active site [active] 1415167006485 heme pocket [chemical binding]; other site 1415167006486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167006487 dimer interface [polypeptide binding]; other site 1415167006488 phosphorylation site [posttranslational modification] 1415167006489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167006490 ATP binding site [chemical binding]; other site 1415167006491 Mg2+ binding site [ion binding]; other site 1415167006492 G-X-G motif; other site 1415167006493 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1415167006494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167006495 active site 1415167006496 phosphorylation site [posttranslational modification] 1415167006497 intermolecular recognition site; other site 1415167006498 dimerization interface [polypeptide binding]; other site 1415167006499 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1415167006500 DNA binding site [nucleotide binding] 1415167006501 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1415167006502 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1415167006503 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1415167006504 ResB-like family; Region: ResB; pfam05140 1415167006505 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1415167006506 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1415167006507 RNA binding surface [nucleotide binding]; other site 1415167006508 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1415167006509 active site 1415167006510 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1415167006511 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1415167006512 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1415167006513 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1415167006514 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1415167006515 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1415167006516 segregation and condensation protein B; Region: TIGR00281 1415167006517 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1415167006518 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1415167006519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167006520 Coenzyme A binding pocket [chemical binding]; other site 1415167006521 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1415167006522 homopentamer interface [polypeptide binding]; other site 1415167006523 active site 1415167006524 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1415167006525 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1415167006526 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1415167006527 dimerization interface [polypeptide binding]; other site 1415167006528 active site 1415167006529 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1415167006530 Lumazine binding domain; Region: Lum_binding; pfam00677 1415167006531 Lumazine binding domain; Region: Lum_binding; pfam00677 1415167006532 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1415167006533 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1415167006534 catalytic motif [active] 1415167006535 Zn binding site [ion binding]; other site 1415167006536 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1415167006537 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1415167006538 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1415167006539 Catalytic site [active] 1415167006540 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 1415167006541 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1415167006542 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1415167006543 active site 1415167006544 Predicted secreted protein [Function unknown]; Region: COG4086 1415167006545 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1415167006546 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1415167006547 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1415167006548 active site 1415167006549 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1415167006550 substrate binding site [chemical binding]; other site 1415167006551 catalytic residues [active] 1415167006552 dimer interface [polypeptide binding]; other site 1415167006553 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1415167006554 stage V sporulation protein AD; Validated; Region: PRK08304 1415167006555 stage V sporulation protein AD; Provisional; Region: PRK12404 1415167006556 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1415167006557 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1415167006558 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1415167006559 sporulation sigma factor SigF; Validated; Region: PRK05572 1415167006560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167006561 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1415167006562 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167006563 DNA binding residues [nucleotide binding] 1415167006564 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1415167006565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167006566 ATP binding site [chemical binding]; other site 1415167006567 Mg2+ binding site [ion binding]; other site 1415167006568 G-X-G motif; other site 1415167006569 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1415167006570 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1415167006571 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1415167006572 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1415167006573 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1415167006574 phosphopentomutase; Provisional; Region: PRK05362 1415167006575 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1415167006576 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1415167006577 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1415167006578 active site 1415167006579 Int/Topo IB signature motif; other site 1415167006580 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1415167006581 ferric uptake regulator; Provisional; Region: fur; PRK09462 1415167006582 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1415167006583 metal binding site 2 [ion binding]; metal-binding site 1415167006584 putative DNA binding helix; other site 1415167006585 metal binding site 1 [ion binding]; metal-binding site 1415167006586 dimer interface [polypeptide binding]; other site 1415167006587 structural Zn2+ binding site [ion binding]; other site 1415167006588 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1415167006589 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1415167006590 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1415167006591 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1415167006592 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1415167006593 NAD(P) binding pocket [chemical binding]; other site 1415167006594 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1415167006595 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1415167006596 Aspartase; Region: Aspartase; cd01357 1415167006597 active sites [active] 1415167006598 tetramer interface [polypeptide binding]; other site 1415167006599 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1415167006600 active site 1415167006601 homodimer interface [polypeptide binding]; other site 1415167006602 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1415167006603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167006604 non-specific DNA binding site [nucleotide binding]; other site 1415167006605 salt bridge; other site 1415167006606 sequence-specific DNA binding site [nucleotide binding]; other site 1415167006607 TIGR00375 family protein; Region: TIGR00375 1415167006608 PHP-associated; Region: PHP_C; pfam13263 1415167006609 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1415167006610 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1415167006611 dimer interface [polypeptide binding]; other site 1415167006612 ADP-ribose binding site [chemical binding]; other site 1415167006613 active site 1415167006614 nudix motif; other site 1415167006615 metal binding site [ion binding]; metal-binding site 1415167006616 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1415167006617 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1415167006618 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1415167006619 active site 1415167006620 catalytic tetrad [active] 1415167006621 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1415167006622 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1415167006623 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1415167006624 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1415167006625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1415167006626 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1415167006627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167006628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1415167006629 Coenzyme A binding pocket [chemical binding]; other site 1415167006630 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1415167006631 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1415167006632 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1415167006633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167006634 Coenzyme A binding pocket [chemical binding]; other site 1415167006635 YolD-like protein; Region: YolD; pfam08863 1415167006636 DNA polymerase IV; Reviewed; Region: PRK03103 1415167006637 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1415167006638 active site 1415167006639 DNA binding site [nucleotide binding] 1415167006640 YqzH-like protein; Region: YqzH; pfam14164 1415167006641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167006642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167006643 putative substrate translocation pore; other site 1415167006644 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1415167006645 putative dimer interface [polypeptide binding]; other site 1415167006646 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167006647 ligand binding site [chemical binding]; other site 1415167006648 Zn binding site [ion binding]; other site 1415167006649 pantothenate kinase; Provisional; Region: PRK05439 1415167006650 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1415167006651 ATP-binding site [chemical binding]; other site 1415167006652 CoA-binding site [chemical binding]; other site 1415167006653 Mg2+-binding site [ion binding]; other site 1415167006654 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1415167006655 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1415167006656 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1415167006657 catalytic residue [active] 1415167006658 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1415167006659 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 1415167006660 NADP binding site [chemical binding]; other site 1415167006661 homodimer interface [polypeptide binding]; other site 1415167006662 substrate binding site [chemical binding]; other site 1415167006663 active site 1415167006664 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1415167006665 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1415167006666 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1415167006667 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1415167006668 putative metal binding site [ion binding]; other site 1415167006669 putative dimer interface [polypeptide binding]; other site 1415167006670 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1415167006671 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1415167006672 active site 1415167006673 FMN binding site [chemical binding]; other site 1415167006674 substrate binding site [chemical binding]; other site 1415167006675 homotetramer interface [polypeptide binding]; other site 1415167006676 catalytic residue [active] 1415167006677 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1415167006678 putative hydrolase; Provisional; Region: PRK02113 1415167006679 ribonuclease Z; Region: RNase_Z; TIGR02651 1415167006680 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1415167006681 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1415167006682 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1415167006683 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1415167006684 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1415167006685 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1415167006686 DNA polymerase IV; Validated; Region: PRK01810 1415167006687 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1415167006688 active site 1415167006689 DNA binding site [nucleotide binding] 1415167006690 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1415167006691 OxaA-like protein precursor; Validated; Region: PRK01622 1415167006692 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1415167006693 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 1415167006694 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1415167006695 peptidase T-like protein; Region: PepT-like; TIGR01883 1415167006696 metal binding site [ion binding]; metal-binding site 1415167006697 putative dimer interface [polypeptide binding]; other site 1415167006698 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1415167006699 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1415167006700 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1415167006701 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167006702 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1415167006703 dimer interface [polypeptide binding]; other site 1415167006704 substrate binding site [chemical binding]; other site 1415167006705 metal binding site [ion binding]; metal-binding site 1415167006706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1415167006707 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1415167006708 Predicted membrane protein [Function unknown]; Region: COG4129 1415167006709 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1415167006710 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1415167006711 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1415167006712 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1415167006713 Walker A/P-loop; other site 1415167006714 ATP binding site [chemical binding]; other site 1415167006715 Q-loop/lid; other site 1415167006716 ABC transporter signature motif; other site 1415167006717 Walker B; other site 1415167006718 D-loop; other site 1415167006719 H-loop/switch region; other site 1415167006720 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1415167006721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167006722 dimer interface [polypeptide binding]; other site 1415167006723 conserved gate region; other site 1415167006724 putative PBP binding loops; other site 1415167006725 ABC-ATPase subunit interface; other site 1415167006726 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1415167006727 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1415167006728 substrate binding pocket [chemical binding]; other site 1415167006729 membrane-bound complex binding site; other site 1415167006730 hinge residues; other site 1415167006731 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1415167006732 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1415167006733 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1415167006734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167006735 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167006736 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1415167006737 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1415167006738 DNA binding residues [nucleotide binding] 1415167006739 drug binding residues [chemical binding]; other site 1415167006740 dimer interface [polypeptide binding]; other site 1415167006741 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1415167006742 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1415167006743 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1415167006744 E3 interaction surface; other site 1415167006745 lipoyl attachment site [posttranslational modification]; other site 1415167006746 e3 binding domain; Region: E3_binding; pfam02817 1415167006747 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1415167006748 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1415167006749 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1415167006750 alpha subunit interface [polypeptide binding]; other site 1415167006751 TPP binding site [chemical binding]; other site 1415167006752 heterodimer interface [polypeptide binding]; other site 1415167006753 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1415167006754 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1415167006755 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1415167006756 tetramer interface [polypeptide binding]; other site 1415167006757 TPP-binding site [chemical binding]; other site 1415167006758 heterodimer interface [polypeptide binding]; other site 1415167006759 phosphorylation loop region [posttranslational modification] 1415167006760 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1415167006761 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1415167006762 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1415167006763 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1415167006764 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1415167006765 nucleotide binding site [chemical binding]; other site 1415167006766 Acetokinase family; Region: Acetate_kinase; cl17229 1415167006767 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1415167006768 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1415167006769 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1415167006770 NAD binding site [chemical binding]; other site 1415167006771 Phe binding site; other site 1415167006772 phosphate butyryltransferase; Validated; Region: PRK07742 1415167006773 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1415167006774 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167006775 putative active site [active] 1415167006776 heme pocket [chemical binding]; other site 1415167006777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167006778 putative active site [active] 1415167006779 heme pocket [chemical binding]; other site 1415167006780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167006781 Walker A motif; other site 1415167006782 ATP binding site [chemical binding]; other site 1415167006783 Walker B motif; other site 1415167006784 arginine finger; other site 1415167006785 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1415167006786 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1415167006787 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1415167006788 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1415167006789 tetramer interface [polypeptide binding]; other site 1415167006790 active site 1415167006791 Mg2+/Mn2+ binding site [ion binding]; other site 1415167006792 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1415167006793 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1415167006794 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1415167006795 dimer interface [polypeptide binding]; other site 1415167006796 Citrate synthase; Region: Citrate_synt; pfam00285 1415167006797 active site 1415167006798 coenzyme A binding site [chemical binding]; other site 1415167006799 citrylCoA binding site [chemical binding]; other site 1415167006800 oxalacetate/citrate binding site [chemical binding]; other site 1415167006801 catalytic triad [active] 1415167006802 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1415167006803 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1415167006804 FAD binding site [chemical binding]; other site 1415167006805 homotetramer interface [polypeptide binding]; other site 1415167006806 substrate binding pocket [chemical binding]; other site 1415167006807 catalytic base [active] 1415167006808 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1415167006809 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1415167006810 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1415167006811 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1415167006812 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1415167006813 dimer interface [polypeptide binding]; other site 1415167006814 active site 1415167006815 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1415167006816 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1415167006817 active site 1415167006818 catalytic site [active] 1415167006819 metal binding site [ion binding]; metal-binding site 1415167006820 dimer interface [polypeptide binding]; other site 1415167006821 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1415167006822 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1415167006823 active site 1415167006824 metal binding site [ion binding]; metal-binding site 1415167006825 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1415167006826 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1415167006827 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1415167006828 putative active site [active] 1415167006829 putative FMN binding site [chemical binding]; other site 1415167006830 putative substrate binding site [chemical binding]; other site 1415167006831 putative catalytic residue [active] 1415167006832 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1415167006833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167006834 active site 1415167006835 phosphorylation site [posttranslational modification] 1415167006836 intermolecular recognition site; other site 1415167006837 dimerization interface [polypeptide binding]; other site 1415167006838 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1415167006839 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1415167006840 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1415167006841 protein binding site [polypeptide binding]; other site 1415167006842 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1415167006843 DNA repair protein RecN; Region: recN; TIGR00634 1415167006844 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1415167006845 Walker A/P-loop; other site 1415167006846 ATP binding site [chemical binding]; other site 1415167006847 Q-loop/lid; other site 1415167006848 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1415167006849 ABC transporter signature motif; other site 1415167006850 Walker B; other site 1415167006851 D-loop; other site 1415167006852 H-loop/switch region; other site 1415167006853 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1415167006854 arginine repressor; Provisional; Region: PRK04280 1415167006855 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1415167006856 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1415167006857 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1415167006858 RNA binding surface [nucleotide binding]; other site 1415167006859 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1415167006860 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1415167006861 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1415167006862 TPP-binding site; other site 1415167006863 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1415167006864 PYR/PP interface [polypeptide binding]; other site 1415167006865 dimer interface [polypeptide binding]; other site 1415167006866 TPP binding site [chemical binding]; other site 1415167006867 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1415167006868 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1415167006869 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1415167006870 substrate binding pocket [chemical binding]; other site 1415167006871 chain length determination region; other site 1415167006872 substrate-Mg2+ binding site; other site 1415167006873 catalytic residues [active] 1415167006874 aspartate-rich region 1; other site 1415167006875 active site lid residues [active] 1415167006876 aspartate-rich region 2; other site 1415167006877 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1415167006878 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1415167006879 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1415167006880 generic binding surface II; other site 1415167006881 generic binding surface I; other site 1415167006882 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1415167006883 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1415167006884 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1415167006885 homodimer interface [polypeptide binding]; other site 1415167006886 NADP binding site [chemical binding]; other site 1415167006887 substrate binding site [chemical binding]; other site 1415167006888 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1415167006889 putative RNA binding site [nucleotide binding]; other site 1415167006890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1415167006891 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1415167006892 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1415167006893 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1415167006894 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1415167006895 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1415167006896 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1415167006897 carboxyltransferase (CT) interaction site; other site 1415167006898 biotinylation site [posttranslational modification]; other site 1415167006899 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1415167006900 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1415167006901 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1415167006902 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1415167006903 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1415167006904 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1415167006905 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1415167006906 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1415167006907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167006908 Walker A motif; other site 1415167006909 ATP binding site [chemical binding]; other site 1415167006910 Walker B motif; other site 1415167006911 arginine finger; other site 1415167006912 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1415167006913 elongation factor P; Validated; Region: PRK00529 1415167006914 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1415167006915 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1415167006916 RNA binding site [nucleotide binding]; other site 1415167006917 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1415167006918 RNA binding site [nucleotide binding]; other site 1415167006919 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1415167006920 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1415167006921 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1415167006922 active site 1415167006923 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1415167006924 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1415167006925 trimer interface [polypeptide binding]; other site 1415167006926 active site 1415167006927 dimer interface [polypeptide binding]; other site 1415167006928 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1415167006929 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1415167006930 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1415167006931 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1415167006932 active site 1415167006933 nucleophile elbow; other site 1415167006934 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1415167006935 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1415167006936 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1415167006937 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1415167006938 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1415167006939 active site residue [active] 1415167006940 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1415167006941 tetramer interface [polypeptide binding]; other site 1415167006942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167006943 catalytic residue [active] 1415167006944 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1415167006945 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1415167006946 tetramer interface [polypeptide binding]; other site 1415167006947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167006948 catalytic residue [active] 1415167006949 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1415167006950 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1415167006951 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1415167006952 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1415167006953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1415167006954 ATP binding site [chemical binding]; other site 1415167006955 putative Mg++ binding site [ion binding]; other site 1415167006956 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167006957 nucleotide binding region [chemical binding]; other site 1415167006958 ATP-binding site [chemical binding]; other site 1415167006959 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1415167006960 Anti-repressor SinI; Region: SinI; pfam08671 1415167006961 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1415167006962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167006963 non-specific DNA binding site [nucleotide binding]; other site 1415167006964 salt bridge; other site 1415167006965 sequence-specific DNA binding site [nucleotide binding]; other site 1415167006966 Anti-repressor SinI; Region: SinI; pfam08671 1415167006967 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1415167006968 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1415167006969 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1415167006970 Catalytic site [active] 1415167006971 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1415167006972 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1415167006973 YqzE-like protein; Region: YqzE; pfam14038 1415167006974 ComG operon protein 7; Region: ComGG; pfam14173 1415167006975 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1415167006976 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1415167006977 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1415167006978 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1415167006979 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1415167006980 Type II/IV secretion system protein; Region: T2SE; pfam00437 1415167006981 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1415167006982 Walker A motif; other site 1415167006983 ATP binding site [chemical binding]; other site 1415167006984 Walker B motif; other site 1415167006985 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1415167006986 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1415167006987 Cl binding site [ion binding]; other site 1415167006988 oligomer interface [polypeptide binding]; other site 1415167006989 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1415167006990 Domain of unknown function DUF21; Region: DUF21; pfam01595 1415167006991 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1415167006992 Transporter associated domain; Region: CorC_HlyC; smart01091 1415167006993 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1415167006994 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1415167006995 ArsC family; Region: ArsC; pfam03960 1415167006996 putative catalytic residues [active] 1415167006997 thiol/disulfide switch; other site 1415167006998 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1415167006999 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1415167007000 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1415167007001 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1415167007002 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1415167007003 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1415167007004 putative active site [active] 1415167007005 Zn binding site [ion binding]; other site 1415167007006 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1415167007007 Sulfatase; Region: Sulfatase; pfam00884 1415167007008 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1415167007009 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1415167007010 nucleotide binding site [chemical binding]; other site 1415167007011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1415167007012 Rhomboid family; Region: Rhomboid; pfam01694 1415167007013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167007014 binding surface 1415167007015 TPR motif; other site 1415167007016 TPR repeat; Region: TPR_11; pfam13414 1415167007017 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1415167007018 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1415167007019 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1415167007020 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1415167007021 YceG-like family; Region: YceG; pfam02618 1415167007022 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1415167007023 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1415167007024 Walker A/P-loop; other site 1415167007025 ATP binding site [chemical binding]; other site 1415167007026 Q-loop/lid; other site 1415167007027 ABC transporter signature motif; other site 1415167007028 Walker B; other site 1415167007029 D-loop; other site 1415167007030 H-loop/switch region; other site 1415167007031 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1415167007032 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1415167007033 Walker A/P-loop; other site 1415167007034 ATP binding site [chemical binding]; other site 1415167007035 Q-loop/lid; other site 1415167007036 ABC transporter signature motif; other site 1415167007037 Walker B; other site 1415167007038 D-loop; other site 1415167007039 H-loop/switch region; other site 1415167007040 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1415167007041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167007042 dimer interface [polypeptide binding]; other site 1415167007043 conserved gate region; other site 1415167007044 ABC-ATPase subunit interface; other site 1415167007045 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1415167007046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167007047 dimer interface [polypeptide binding]; other site 1415167007048 conserved gate region; other site 1415167007049 putative PBP binding loops; other site 1415167007050 ABC-ATPase subunit interface; other site 1415167007051 PBP superfamily domain; Region: PBP_like_2; cl17296 1415167007052 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1415167007053 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1415167007054 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1415167007055 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1415167007056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167007057 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167007058 putative substrate translocation pore; other site 1415167007059 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1415167007060 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1415167007061 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1415167007062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1415167007063 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1415167007064 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167007065 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1415167007066 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1415167007067 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1415167007068 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1415167007069 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1415167007070 ferric uptake regulator; Provisional; Region: fur; PRK09462 1415167007071 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1415167007072 metal binding site 2 [ion binding]; metal-binding site 1415167007073 putative DNA binding helix; other site 1415167007074 metal binding site 1 [ion binding]; metal-binding site 1415167007075 dimer interface [polypeptide binding]; other site 1415167007076 structural Zn2+ binding site [ion binding]; other site 1415167007077 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1415167007078 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167007079 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167007080 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1415167007081 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1415167007082 endonuclease IV; Provisional; Region: PRK01060 1415167007083 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1415167007084 AP (apurinic/apyrimidinic) site pocket; other site 1415167007085 DNA interaction; other site 1415167007086 Metal-binding active site; metal-binding site 1415167007087 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1415167007088 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1415167007089 ATP binding site [chemical binding]; other site 1415167007090 Mg++ binding site [ion binding]; other site 1415167007091 motif III; other site 1415167007092 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167007093 nucleotide binding region [chemical binding]; other site 1415167007094 ATP-binding site [chemical binding]; other site 1415167007095 YqfQ-like protein; Region: YqfQ; pfam14181 1415167007096 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1415167007097 LytB protein; Region: LYTB; pfam02401 1415167007098 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1415167007099 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 1415167007100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1415167007101 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1415167007102 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1415167007103 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1415167007104 Family of unknown function (DUF633); Region: DUF633; pfam04816 1415167007105 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1415167007106 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1415167007107 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1415167007108 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1415167007109 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1415167007110 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167007111 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1415167007112 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167007113 DNA binding residues [nucleotide binding] 1415167007114 DNA primase; Validated; Region: dnaG; PRK05667 1415167007115 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1415167007116 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1415167007117 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1415167007118 active site 1415167007119 metal binding site [ion binding]; metal-binding site 1415167007120 interdomain interaction site; other site 1415167007121 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1415167007122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1415167007123 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1415167007124 HTH domain; Region: HTH_11; pfam08279 1415167007125 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1415167007126 FOG: CBS domain [General function prediction only]; Region: COG0517 1415167007127 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1415167007128 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1415167007129 dimer interface [polypeptide binding]; other site 1415167007130 motif 1; other site 1415167007131 active site 1415167007132 motif 2; other site 1415167007133 motif 3; other site 1415167007134 Recombination protein O N terminal; Region: RecO_N; pfam11967 1415167007135 DNA repair protein RecO; Region: reco; TIGR00613 1415167007136 Recombination protein O C terminal; Region: RecO_C; pfam02565 1415167007137 YqzL-like protein; Region: YqzL; pfam14006 1415167007138 GTPase Era; Reviewed; Region: era; PRK00089 1415167007139 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1415167007140 G1 box; other site 1415167007141 GTP/Mg2+ binding site [chemical binding]; other site 1415167007142 Switch I region; other site 1415167007143 G2 box; other site 1415167007144 Switch II region; other site 1415167007145 G3 box; other site 1415167007146 G4 box; other site 1415167007147 G5 box; other site 1415167007148 KH domain; Region: KH_2; pfam07650 1415167007149 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1415167007150 active site 1415167007151 catalytic motif [active] 1415167007152 Zn binding site [ion binding]; other site 1415167007153 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1415167007154 metal-binding heat shock protein; Provisional; Region: PRK00016 1415167007155 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1415167007156 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1415167007157 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1415167007158 Zn2+ binding site [ion binding]; other site 1415167007159 Mg2+ binding site [ion binding]; other site 1415167007160 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1415167007161 PhoH-like protein; Region: PhoH; pfam02562 1415167007162 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1415167007163 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1415167007164 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1415167007165 hypothetical protein; Provisional; Region: PRK13665 1415167007166 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1415167007167 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1415167007168 dimer interface [polypeptide binding]; other site 1415167007169 active site residues [active] 1415167007170 Yqey-like protein; Region: YqeY; pfam09424 1415167007171 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1415167007172 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1415167007173 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1415167007174 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1415167007175 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1415167007176 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1415167007177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167007178 FeS/SAM binding site; other site 1415167007179 TRAM domain; Region: TRAM; cl01282 1415167007180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1415167007181 RNA methyltransferase, RsmE family; Region: TIGR00046 1415167007182 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1415167007183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167007184 S-adenosylmethionine binding site [chemical binding]; other site 1415167007185 chaperone protein DnaJ; Provisional; Region: PRK14280 1415167007186 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1415167007187 HSP70 interaction site [polypeptide binding]; other site 1415167007188 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1415167007189 substrate binding site [polypeptide binding]; other site 1415167007190 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1415167007191 Zn binding sites [ion binding]; other site 1415167007192 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1415167007193 dimer interface [polypeptide binding]; other site 1415167007194 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1415167007195 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1415167007196 nucleotide binding site [chemical binding]; other site 1415167007197 NEF interaction site [polypeptide binding]; other site 1415167007198 SBD interface [polypeptide binding]; other site 1415167007199 GrpE; Region: GrpE; pfam01025 1415167007200 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1415167007201 dimer interface [polypeptide binding]; other site 1415167007202 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1415167007203 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1415167007204 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1415167007205 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1415167007206 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167007207 FeS/SAM binding site; other site 1415167007208 HemN C-terminal domain; Region: HemN_C; pfam06969 1415167007209 GTP-binding protein LepA; Provisional; Region: PRK05433 1415167007210 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1415167007211 G1 box; other site 1415167007212 putative GEF interaction site [polypeptide binding]; other site 1415167007213 GTP/Mg2+ binding site [chemical binding]; other site 1415167007214 Switch I region; other site 1415167007215 G2 box; other site 1415167007216 G3 box; other site 1415167007217 Switch II region; other site 1415167007218 G4 box; other site 1415167007219 G5 box; other site 1415167007220 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1415167007221 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1415167007222 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1415167007223 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1415167007224 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1415167007225 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1415167007226 germination protease; Provisional; Region: PRK02858 1415167007227 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1415167007228 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1415167007229 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1415167007230 YqzM-like protein; Region: YqzM; pfam14141 1415167007231 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1415167007232 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1415167007233 Competence protein; Region: Competence; pfam03772 1415167007234 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1415167007235 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1415167007236 catalytic motif [active] 1415167007237 Zn binding site [ion binding]; other site 1415167007238 SLBB domain; Region: SLBB; pfam10531 1415167007239 comEA protein; Region: comE; TIGR01259 1415167007240 Helix-hairpin-helix motif; Region: HHH; pfam00633 1415167007241 late competence protein ComER; Validated; Region: PRK07680 1415167007242 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1415167007243 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1415167007244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167007245 S-adenosylmethionine binding site [chemical binding]; other site 1415167007246 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1415167007247 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1415167007248 Zn2+ binding site [ion binding]; other site 1415167007249 Mg2+ binding site [ion binding]; other site 1415167007250 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1415167007251 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1415167007252 active site 1415167007253 (T/H)XGH motif; other site 1415167007254 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 1415167007255 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1415167007256 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1415167007257 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1415167007258 shikimate binding site; other site 1415167007259 NAD(P) binding site [chemical binding]; other site 1415167007260 GTPase YqeH; Provisional; Region: PRK13796 1415167007261 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1415167007262 GTP/Mg2+ binding site [chemical binding]; other site 1415167007263 G4 box; other site 1415167007264 G5 box; other site 1415167007265 G1 box; other site 1415167007266 Switch I region; other site 1415167007267 G2 box; other site 1415167007268 G3 box; other site 1415167007269 Switch II region; other site 1415167007270 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1415167007271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167007272 active site 1415167007273 motif I; other site 1415167007274 motif II; other site 1415167007275 Sporulation inhibitor A; Region: Sda; pfam08970 1415167007276 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 1415167007277 active site 1415167007278 catalytic triad [active] 1415167007279 oxyanion hole [active] 1415167007280 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1415167007281 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1415167007282 amidase catalytic site [active] 1415167007283 Zn binding residues [ion binding]; other site 1415167007284 substrate binding site [chemical binding]; other site 1415167007285 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1415167007286 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1415167007287 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1415167007288 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1415167007289 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1415167007290 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1415167007291 arginine decarboxylase; Provisional; Region: PRK15029 1415167007292 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1415167007293 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1415167007294 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1415167007295 catalytic residues [active] 1415167007296 Recombinase; Region: Recombinase; pfam07508 1415167007297 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1415167007298 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1415167007299 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1415167007300 active site 1415167007301 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1415167007302 arsenical-resistance protein; Region: acr3; TIGR00832 1415167007303 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1415167007304 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167007305 putative metal binding site [ion binding]; other site 1415167007306 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167007307 dimerization interface [polypeptide binding]; other site 1415167007308 putative DNA binding site [nucleotide binding]; other site 1415167007309 putative Zn2+ binding site [ion binding]; other site 1415167007310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167007311 binding surface 1415167007312 TPR motif; other site 1415167007313 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1415167007314 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1415167007315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167007316 TPR motif; other site 1415167007317 binding surface 1415167007318 TPR repeat; Region: TPR_11; pfam13414 1415167007319 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1415167007320 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1415167007321 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 1415167007322 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1415167007323 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1415167007324 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1415167007325 amidase catalytic site [active] 1415167007326 Zn binding residues [ion binding]; other site 1415167007327 substrate binding site [chemical binding]; other site 1415167007328 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1415167007329 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1415167007330 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1415167007331 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 1415167007332 C1q domain; Region: C1q; cl17543 1415167007333 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1415167007334 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1415167007335 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1415167007336 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1415167007337 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1415167007338 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167007339 Phage-related minor tail protein [Function unknown]; Region: COG5280 1415167007340 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1415167007341 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1415167007342 catalytic residue [active] 1415167007343 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1415167007344 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1415167007345 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1415167007346 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1415167007347 Phage capsid family; Region: Phage_capsid; pfam05065 1415167007348 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 1415167007349 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1415167007350 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1415167007351 Terminase-like family; Region: Terminase_6; pfam03237 1415167007352 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1415167007353 Helix-turn-helix domain; Region: HTH_28; pfam13518 1415167007354 Homeodomain-like domain; Region: HTH_23; cl17451 1415167007355 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1415167007356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167007357 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1415167007358 Walker A motif; other site 1415167007359 ATP binding site [chemical binding]; other site 1415167007360 Walker B motif; other site 1415167007361 arginine finger; other site 1415167007362 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1415167007363 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 1415167007364 Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377 1415167007365 Hypothetical protein Yqai; Region: Yqai; pfam09466 1415167007366 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167007367 non-specific DNA binding site [nucleotide binding]; other site 1415167007368 salt bridge; other site 1415167007369 sequence-specific DNA binding site [nucleotide binding]; other site 1415167007370 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1415167007371 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167007372 non-specific DNA binding site [nucleotide binding]; other site 1415167007373 salt bridge; other site 1415167007374 sequence-specific DNA binding site [nucleotide binding]; other site 1415167007375 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1415167007376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167007377 non-specific DNA binding site [nucleotide binding]; other site 1415167007378 salt bridge; other site 1415167007379 sequence-specific DNA binding site [nucleotide binding]; other site 1415167007380 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1415167007381 hypothetical protein; Validated; Region: PRK06217 1415167007382 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1415167007383 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1415167007384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167007385 DNA binding residues [nucleotide binding] 1415167007386 Predicted membrane protein [Function unknown]; Region: COG3223 1415167007387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1415167007388 HAMP domain; Region: HAMP; pfam00672 1415167007389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167007390 dimer interface [polypeptide binding]; other site 1415167007391 phosphorylation site [posttranslational modification] 1415167007392 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1415167007393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167007394 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1415167007395 active site 1415167007396 phosphorylation site [posttranslational modification] 1415167007397 intermolecular recognition site; other site 1415167007398 dimerization interface [polypeptide binding]; other site 1415167007399 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1415167007400 DNA binding site [nucleotide binding] 1415167007401 Predicted membrane protein [Function unknown]; Region: COG2311 1415167007402 Protein of unknown function (DUF418); Region: DUF418; cl12135 1415167007403 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1415167007404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167007405 Coenzyme A binding pocket [chemical binding]; other site 1415167007406 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1415167007407 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1415167007408 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1415167007409 CPxP motif; other site 1415167007410 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1415167007411 active site residue [active] 1415167007412 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1415167007413 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1415167007414 CPxP motif; other site 1415167007415 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1415167007416 active site residue [active] 1415167007417 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1415167007418 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1415167007419 putative homodimer interface [polypeptide binding]; other site 1415167007420 putative homotetramer interface [polypeptide binding]; other site 1415167007421 putative allosteric switch controlling residues; other site 1415167007422 putative metal binding site [ion binding]; other site 1415167007423 putative homodimer-homodimer interface [polypeptide binding]; other site 1415167007424 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1415167007425 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1415167007426 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1415167007427 DNA binding residues [nucleotide binding] 1415167007428 dimer interface [polypeptide binding]; other site 1415167007429 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1415167007430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167007431 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167007432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167007433 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1415167007434 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1415167007435 Coenzyme A binding pocket [chemical binding]; other site 1415167007436 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1415167007437 Domain of unknown function DUF21; Region: DUF21; pfam01595 1415167007438 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1415167007439 Transporter associated domain; Region: CorC_HlyC; smart01091 1415167007440 YrzO-like protein; Region: YrzO; pfam14142 1415167007441 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1415167007442 EamA-like transporter family; Region: EamA; pfam00892 1415167007443 EamA-like transporter family; Region: EamA; pfam00892 1415167007444 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167007445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167007446 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1415167007447 putative dimerization interface [polypeptide binding]; other site 1415167007448 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1415167007449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1415167007450 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1415167007451 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1415167007452 Tautomerase enzyme; Region: Tautomerase; pfam01361 1415167007453 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167007454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167007455 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1415167007456 putative dimerization interface [polypeptide binding]; other site 1415167007457 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1415167007458 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 1415167007459 4-azaleucine resistance probable transporter AzlC; Region: azlC; TIGR00346 1415167007460 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1415167007461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167007462 putative DNA binding site [nucleotide binding]; other site 1415167007463 putative Zn2+ binding site [ion binding]; other site 1415167007464 AsnC family; Region: AsnC_trans_reg; pfam01037 1415167007465 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1415167007466 RNAase interaction site [polypeptide binding]; other site 1415167007467 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1415167007468 Cytochrome P450; Region: p450; cl12078 1415167007469 Isochorismatase family; Region: Isochorismatase; pfam00857 1415167007470 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1415167007471 catalytic triad [active] 1415167007472 conserved cis-peptide bond; other site 1415167007473 DinB family; Region: DinB; pfam05163 1415167007474 DinB superfamily; Region: DinB_2; pfam12867 1415167007475 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1415167007476 Nitronate monooxygenase; Region: NMO; pfam03060 1415167007477 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1415167007478 FMN binding site [chemical binding]; other site 1415167007479 substrate binding site [chemical binding]; other site 1415167007480 putative catalytic residue [active] 1415167007481 glutamate racemase; Region: glut_race; TIGR00067 1415167007482 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1415167007483 putative binding site; other site 1415167007484 putative dimer interface [polypeptide binding]; other site 1415167007485 YodA lipocalin-like domain; Region: YodA; pfam09223 1415167007486 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 1415167007487 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167007488 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167007489 DNA binding residues [nucleotide binding] 1415167007490 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1415167007491 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1415167007492 active site 1415167007493 catalytic tetrad [active] 1415167007494 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1415167007495 Citrate transporter; Region: CitMHS; pfam03600 1415167007496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167007497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167007498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1415167007499 dimerization interface [polypeptide binding]; other site 1415167007500 PrpF protein; Region: PrpF; pfam04303 1415167007501 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1415167007502 chitosan binding site [chemical binding]; other site 1415167007503 catalytic residues [active] 1415167007504 Mor transcription activator family; Region: Mor; cl02360 1415167007505 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1415167007506 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1415167007507 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1415167007508 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1415167007509 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1415167007510 Bacterial SH3 domain; Region: SH3_3; cl17532 1415167007511 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167007512 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1415167007513 active site 1415167007514 metal binding site [ion binding]; metal-binding site 1415167007515 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1415167007516 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1415167007517 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1415167007518 NAD binding site [chemical binding]; other site 1415167007519 catalytic Zn binding site [ion binding]; other site 1415167007520 structural Zn binding site [ion binding]; other site 1415167007521 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1415167007522 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1415167007523 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1415167007524 DNA binding residues [nucleotide binding] 1415167007525 putative dimer interface [polypeptide binding]; other site 1415167007526 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1415167007527 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1415167007528 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1415167007529 putative NAD(P) binding site [chemical binding]; other site 1415167007530 putative substrate binding site [chemical binding]; other site 1415167007531 catalytic Zn binding site [ion binding]; other site 1415167007532 structural Zn binding site [ion binding]; other site 1415167007533 dimer interface [polypeptide binding]; other site 1415167007534 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1415167007535 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1415167007536 proposed catalytic triad [active] 1415167007537 conserved cys residue [active] 1415167007538 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1415167007539 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1415167007540 substrate binding [chemical binding]; other site 1415167007541 active site 1415167007542 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1415167007543 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1415167007544 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 1415167007545 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1415167007546 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1415167007547 active site 1415167007548 phosphorylation site [posttranslational modification] 1415167007549 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1415167007550 active pocket/dimerization site; other site 1415167007551 active site 1415167007552 phosphorylation site [posttranslational modification] 1415167007553 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1415167007554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167007555 Walker A motif; other site 1415167007556 ATP binding site [chemical binding]; other site 1415167007557 Walker B motif; other site 1415167007558 arginine finger; other site 1415167007559 Transcriptional antiterminator [Transcription]; Region: COG3933 1415167007560 PRD domain; Region: PRD; pfam00874 1415167007561 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1415167007562 active pocket/dimerization site; other site 1415167007563 active site 1415167007564 phosphorylation site [posttranslational modification] 1415167007565 PRD domain; Region: PRD; pfam00874 1415167007566 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1415167007567 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1415167007568 Predicted transcriptional regulators [Transcription]; Region: COG1378 1415167007569 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1415167007570 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1415167007571 C-terminal domain interface [polypeptide binding]; other site 1415167007572 sugar binding site [chemical binding]; other site 1415167007573 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1415167007574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167007575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167007576 DNA binding residues [nucleotide binding] 1415167007577 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1415167007578 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1415167007579 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1415167007580 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1415167007581 catalytic triad [active] 1415167007582 catalytic triad [active] 1415167007583 oxyanion hole [active] 1415167007584 YrhK-like protein; Region: YrhK; pfam14145 1415167007585 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1415167007586 Cytochrome P450; Region: p450; pfam00067 1415167007587 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1415167007588 Flavodoxin; Region: Flavodoxin_1; pfam00258 1415167007589 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1415167007590 FAD binding pocket [chemical binding]; other site 1415167007591 FAD binding motif [chemical binding]; other site 1415167007592 catalytic residues [active] 1415167007593 NAD binding pocket [chemical binding]; other site 1415167007594 phosphate binding motif [ion binding]; other site 1415167007595 beta-alpha-beta structure motif; other site 1415167007596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167007597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167007598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167007599 S-adenosylmethionine binding site [chemical binding]; other site 1415167007600 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1415167007601 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1415167007602 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1415167007603 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1415167007604 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1415167007605 catalytic loop [active] 1415167007606 iron binding site [ion binding]; other site 1415167007607 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1415167007608 4Fe-4S binding domain; Region: Fer4; pfam00037 1415167007609 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1415167007610 [4Fe-4S] binding site [ion binding]; other site 1415167007611 molybdopterin cofactor binding site; other site 1415167007612 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1415167007613 molybdopterin cofactor binding site; other site 1415167007614 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1415167007615 YrhC-like protein; Region: YrhC; pfam14143 1415167007616 cystathionine beta-lyase; Provisional; Region: PRK07671 1415167007617 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1415167007618 homodimer interface [polypeptide binding]; other site 1415167007619 substrate-cofactor binding pocket; other site 1415167007620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167007621 catalytic residue [active] 1415167007622 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1415167007623 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1415167007624 dimer interface [polypeptide binding]; other site 1415167007625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167007626 catalytic residue [active] 1415167007627 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1415167007628 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1415167007629 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1415167007630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167007631 S-adenosylmethionine binding site [chemical binding]; other site 1415167007632 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1415167007633 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1415167007634 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1415167007635 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1415167007636 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1415167007637 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1415167007638 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1415167007639 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1415167007640 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1415167007641 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1415167007642 ATP-binding site [chemical binding]; other site 1415167007643 Sugar specificity; other site 1415167007644 Pyrimidine base specificity; other site 1415167007645 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1415167007646 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1415167007647 Peptidase family U32; Region: Peptidase_U32; pfam01136 1415167007648 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1415167007649 Peptidase family U32; Region: Peptidase_U32; pfam01136 1415167007650 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1415167007651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167007652 S-adenosylmethionine binding site [chemical binding]; other site 1415167007653 conserved hypothetical protein, YceG family; Region: TIGR00247 1415167007654 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1415167007655 dimerization interface [polypeptide binding]; other site 1415167007656 hypothetical protein; Provisional; Region: PRK13678 1415167007657 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1415167007658 hypothetical protein; Provisional; Region: PRK05473 1415167007659 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1415167007660 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1415167007661 motif 1; other site 1415167007662 active site 1415167007663 motif 2; other site 1415167007664 motif 3; other site 1415167007665 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1415167007666 DHHA1 domain; Region: DHHA1; pfam02272 1415167007667 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1415167007668 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1415167007669 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1415167007670 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1415167007671 Walker A/P-loop; other site 1415167007672 ATP binding site [chemical binding]; other site 1415167007673 Q-loop/lid; other site 1415167007674 ABC transporter signature motif; other site 1415167007675 Walker B; other site 1415167007676 D-loop; other site 1415167007677 H-loop/switch region; other site 1415167007678 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1415167007679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1415167007680 substrate binding pocket [chemical binding]; other site 1415167007681 membrane-bound complex binding site; other site 1415167007682 hinge residues; other site 1415167007683 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1415167007684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167007685 dimer interface [polypeptide binding]; other site 1415167007686 conserved gate region; other site 1415167007687 putative PBP binding loops; other site 1415167007688 ABC-ATPase subunit interface; other site 1415167007689 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1415167007690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167007691 dimer interface [polypeptide binding]; other site 1415167007692 ABC-ATPase subunit interface; other site 1415167007693 putative PBP binding loops; other site 1415167007694 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 1415167007695 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1415167007696 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1415167007697 AAA domain; Region: AAA_30; pfam13604 1415167007698 Family description; Region: UvrD_C_2; pfam13538 1415167007699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167007700 binding surface 1415167007701 TPR motif; other site 1415167007702 TPR repeat; Region: TPR_11; pfam13414 1415167007703 TPR repeat; Region: TPR_11; pfam13414 1415167007704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167007705 binding surface 1415167007706 TPR motif; other site 1415167007707 TPR repeat; Region: TPR_11; pfam13414 1415167007708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167007709 binding surface 1415167007710 TPR motif; other site 1415167007711 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1415167007712 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1415167007713 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1415167007714 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1415167007715 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1415167007716 catalytic residue [active] 1415167007717 Predicted transcriptional regulator [Transcription]; Region: COG1959 1415167007718 Transcriptional regulator; Region: Rrf2; pfam02082 1415167007719 recombination factor protein RarA; Reviewed; Region: PRK13342 1415167007720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167007721 Walker A motif; other site 1415167007722 ATP binding site [chemical binding]; other site 1415167007723 Walker B motif; other site 1415167007724 arginine finger; other site 1415167007725 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1415167007726 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1415167007727 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1415167007728 putative ATP binding site [chemical binding]; other site 1415167007729 putative substrate interface [chemical binding]; other site 1415167007730 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1415167007731 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1415167007732 dimer interface [polypeptide binding]; other site 1415167007733 anticodon binding site; other site 1415167007734 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1415167007735 homodimer interface [polypeptide binding]; other site 1415167007736 motif 1; other site 1415167007737 active site 1415167007738 motif 2; other site 1415167007739 GAD domain; Region: GAD; pfam02938 1415167007740 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1415167007741 motif 3; other site 1415167007742 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1415167007743 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1415167007744 dimer interface [polypeptide binding]; other site 1415167007745 motif 1; other site 1415167007746 active site 1415167007747 motif 2; other site 1415167007748 motif 3; other site 1415167007749 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1415167007750 anticodon binding site; other site 1415167007751 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1415167007752 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1415167007753 Bacterial SH3 domain; Region: SH3_3; pfam08239 1415167007754 Bacterial SH3 domain; Region: SH3_3; pfam08239 1415167007755 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1415167007756 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1415167007757 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1415167007758 active site 1415167007759 metal binding site [ion binding]; metal-binding site 1415167007760 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1415167007761 dimerization interface [polypeptide binding]; other site 1415167007762 putative tRNAtyr binding site [nucleotide binding]; other site 1415167007763 putative active site [active] 1415167007764 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1415167007765 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1415167007766 Zn2+ binding site [ion binding]; other site 1415167007767 Mg2+ binding site [ion binding]; other site 1415167007768 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1415167007769 synthetase active site [active] 1415167007770 NTP binding site [chemical binding]; other site 1415167007771 metal binding site [ion binding]; metal-binding site 1415167007772 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1415167007773 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1415167007774 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1415167007775 active site 1415167007776 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1415167007777 DHH family; Region: DHH; pfam01368 1415167007778 DHHA1 domain; Region: DHHA1; pfam02272 1415167007779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1415167007780 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1415167007781 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1415167007782 TrkA-C domain; Region: TrkA_C; pfam02080 1415167007783 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1415167007784 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1415167007785 Protein export membrane protein; Region: SecD_SecF; pfam02355 1415167007786 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1415167007787 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1415167007788 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1415167007789 Predicted membrane protein [Function unknown]; Region: COG2323 1415167007790 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1415167007791 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1415167007792 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1415167007793 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1415167007794 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1415167007795 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1415167007796 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1415167007797 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1415167007798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167007799 Walker A motif; other site 1415167007800 ATP binding site [chemical binding]; other site 1415167007801 Walker B motif; other site 1415167007802 arginine finger; other site 1415167007803 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1415167007804 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1415167007805 RuvA N terminal domain; Region: RuvA_N; pfam01330 1415167007806 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1415167007807 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1415167007808 BofC C-terminal domain; Region: BofC_C; pfam08955 1415167007809 polyol permease family; Region: 2A0118; TIGR00897 1415167007810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167007811 putative substrate translocation pore; other site 1415167007812 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1415167007813 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1415167007814 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1415167007815 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1415167007816 active site 1415167007817 substrate binding site [chemical binding]; other site 1415167007818 ATP binding site [chemical binding]; other site 1415167007819 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1415167007820 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1415167007821 hypothetical protein; Validated; Region: PRK00110 1415167007822 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1415167007823 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167007824 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1415167007825 quinolinate synthetase complex, A subunit; Region: nadA; TIGR00550 1415167007826 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1415167007827 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1415167007828 dimerization interface [polypeptide binding]; other site 1415167007829 active site 1415167007830 L-aspartate oxidase; Provisional; Region: PRK08071 1415167007831 L-aspartate oxidase; Provisional; Region: PRK06175 1415167007832 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1415167007833 cysteine desulfurase; Provisional; Region: PRK02948 1415167007834 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1415167007835 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1415167007836 catalytic residue [active] 1415167007837 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1415167007838 HTH domain; Region: HTH_11; pfam08279 1415167007839 3H domain; Region: 3H; pfam02829 1415167007840 prephenate dehydratase; Provisional; Region: PRK11898 1415167007841 Prephenate dehydratase; Region: PDT; pfam00800 1415167007842 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1415167007843 putative L-Phe binding site [chemical binding]; other site 1415167007844 hypothetical protein; Provisional; Region: PRK04435 1415167007845 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1415167007846 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1415167007847 GTP1/OBG; Region: GTP1_OBG; pfam01018 1415167007848 Obg GTPase; Region: Obg; cd01898 1415167007849 G1 box; other site 1415167007850 GTP/Mg2+ binding site [chemical binding]; other site 1415167007851 Switch I region; other site 1415167007852 G2 box; other site 1415167007853 G3 box; other site 1415167007854 Switch II region; other site 1415167007855 G4 box; other site 1415167007856 G5 box; other site 1415167007857 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1415167007858 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1415167007859 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1415167007860 hypothetical protein; Provisional; Region: PRK14553 1415167007861 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1415167007862 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1415167007863 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1415167007864 active site 1415167007865 Peptidase family M50; Region: Peptidase_M50; pfam02163 1415167007866 putative substrate binding region [chemical binding]; other site 1415167007867 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1415167007868 Peptidase family M23; Region: Peptidase_M23; pfam01551 1415167007869 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1415167007870 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1415167007871 Switch I; other site 1415167007872 Switch II; other site 1415167007873 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1415167007874 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1415167007875 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1415167007876 rod shape-determining protein MreC; Region: mreC; TIGR00219 1415167007877 rod shape-determining protein MreC; Region: MreC; pfam04085 1415167007878 rod shape-determining protein MreB; Provisional; Region: PRK13927 1415167007879 MreB and similar proteins; Region: MreB_like; cd10225 1415167007880 nucleotide binding site [chemical binding]; other site 1415167007881 Mg binding site [ion binding]; other site 1415167007882 putative protofilament interaction site [polypeptide binding]; other site 1415167007883 RodZ interaction site [polypeptide binding]; other site 1415167007884 hypothetical protein; Reviewed; Region: PRK00024 1415167007885 Helix-hairpin-helix motif; Region: HHH; pfam00633 1415167007886 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1415167007887 MPN+ (JAMM) motif; other site 1415167007888 Zinc-binding site [ion binding]; other site 1415167007889 Maf-like protein; Region: Maf; pfam02545 1415167007890 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1415167007891 active site 1415167007892 dimer interface [polypeptide binding]; other site 1415167007893 Sporulation related domain; Region: SPOR; pfam05036 1415167007894 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1415167007895 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1415167007896 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1415167007897 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1415167007898 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1415167007899 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1415167007900 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1415167007901 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1415167007902 active site 1415167007903 HIGH motif; other site 1415167007904 nucleotide binding site [chemical binding]; other site 1415167007905 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1415167007906 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1415167007907 active site 1415167007908 KMSKS motif; other site 1415167007909 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1415167007910 tRNA binding surface [nucleotide binding]; other site 1415167007911 anticodon binding site; other site 1415167007912 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1415167007913 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1415167007914 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1415167007915 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1415167007916 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1415167007917 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1415167007918 inhibitor-cofactor binding pocket; inhibition site 1415167007919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167007920 catalytic residue [active] 1415167007921 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1415167007922 dimer interface [polypeptide binding]; other site 1415167007923 active site 1415167007924 Schiff base residues; other site 1415167007925 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1415167007926 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1415167007927 active site 1415167007928 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1415167007929 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1415167007930 domain interfaces; other site 1415167007931 active site 1415167007932 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1415167007933 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1415167007934 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1415167007935 tRNA; other site 1415167007936 putative tRNA binding site [nucleotide binding]; other site 1415167007937 putative NADP binding site [chemical binding]; other site 1415167007938 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1415167007939 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1415167007940 G1 box; other site 1415167007941 GTP/Mg2+ binding site [chemical binding]; other site 1415167007942 Switch I region; other site 1415167007943 G2 box; other site 1415167007944 G3 box; other site 1415167007945 Switch II region; other site 1415167007946 G4 box; other site 1415167007947 G5 box; other site 1415167007948 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1415167007949 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1415167007950 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1415167007951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167007952 Walker A motif; other site 1415167007953 ATP binding site [chemical binding]; other site 1415167007954 Walker B motif; other site 1415167007955 arginine finger; other site 1415167007956 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1415167007957 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1415167007958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167007959 Walker A motif; other site 1415167007960 ATP binding site [chemical binding]; other site 1415167007961 Walker B motif; other site 1415167007962 arginine finger; other site 1415167007963 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1415167007964 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1415167007965 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1415167007966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167007967 Walker A motif; other site 1415167007968 ATP binding site [chemical binding]; other site 1415167007969 Walker B motif; other site 1415167007970 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1415167007971 trigger factor; Provisional; Region: tig; PRK01490 1415167007972 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1415167007973 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1415167007974 TPR repeat; Region: TPR_11; pfam13414 1415167007975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167007976 binding surface 1415167007977 TPR motif; other site 1415167007978 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1415167007979 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1415167007980 substrate binding site [chemical binding]; other site 1415167007981 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1415167007982 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1415167007983 substrate binding site [chemical binding]; other site 1415167007984 ligand binding site [chemical binding]; other site 1415167007985 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1415167007986 tartrate dehydrogenase; Region: TTC; TIGR02089 1415167007987 2-isopropylmalate synthase; Validated; Region: PRK00915 1415167007988 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1415167007989 active site 1415167007990 metal binding site [ion binding]; metal-binding site 1415167007991 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1415167007992 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1415167007993 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1415167007994 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1415167007995 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1415167007996 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1415167007997 putative valine binding site [chemical binding]; other site 1415167007998 dimer interface [polypeptide binding]; other site 1415167007999 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1415167008000 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1415167008001 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1415167008002 PYR/PP interface [polypeptide binding]; other site 1415167008003 dimer interface [polypeptide binding]; other site 1415167008004 TPP binding site [chemical binding]; other site 1415167008005 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1415167008006 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1415167008007 TPP-binding site [chemical binding]; other site 1415167008008 dimer interface [polypeptide binding]; other site 1415167008009 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1415167008010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167008011 Coenzyme A binding pocket [chemical binding]; other site 1415167008012 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1415167008013 Heat induced stress protein YflT; Region: YflT; pfam11181 1415167008014 conserved domain; Region: TIGR02271 1415167008015 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1415167008016 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1415167008017 active site 1415167008018 metal binding site [ion binding]; metal-binding site 1415167008019 homotetramer interface [polypeptide binding]; other site 1415167008020 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1415167008021 active site 1415167008022 dimerization interface [polypeptide binding]; other site 1415167008023 ribonuclease PH; Reviewed; Region: rph; PRK00173 1415167008024 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1415167008025 hexamer interface [polypeptide binding]; other site 1415167008026 active site 1415167008027 Spore germination protein [General function prediction only]; Region: COG5401 1415167008028 Sporulation and spore germination; Region: Germane; pfam10646 1415167008029 Sporulation and spore germination; Region: Germane; pfam10646 1415167008030 glutamate racemase; Region: glut_race; TIGR00067 1415167008031 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167008032 MarR family; Region: MarR; pfam01047 1415167008033 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1415167008034 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1415167008035 DNA binding residues [nucleotide binding] 1415167008036 dimerization interface [polypeptide binding]; other site 1415167008037 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1415167008038 active site 1415167008039 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1415167008040 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1415167008041 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1415167008042 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1415167008043 L-aspartate oxidase; Provisional; Region: PRK06175 1415167008044 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1415167008045 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1415167008046 putative Iron-sulfur protein interface [polypeptide binding]; other site 1415167008047 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1415167008048 proximal heme binding site [chemical binding]; other site 1415167008049 distal heme binding site [chemical binding]; other site 1415167008050 putative dimer interface [polypeptide binding]; other site 1415167008051 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1415167008052 aspartate kinase; Reviewed; Region: PRK06635 1415167008053 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1415167008054 putative nucleotide binding site [chemical binding]; other site 1415167008055 putative catalytic residues [active] 1415167008056 putative Mg ion binding site [ion binding]; other site 1415167008057 putative aspartate binding site [chemical binding]; other site 1415167008058 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1415167008059 putative allosteric regulatory site; other site 1415167008060 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1415167008061 putative allosteric regulatory residue; other site 1415167008062 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1415167008063 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1415167008064 GIY-YIG motif/motif A; other site 1415167008065 active site 1415167008066 catalytic site [active] 1415167008067 putative DNA binding site [nucleotide binding]; other site 1415167008068 metal binding site [ion binding]; metal-binding site 1415167008069 UvrB/uvrC motif; Region: UVR; pfam02151 1415167008070 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1415167008071 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1415167008072 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1415167008073 catalytic residues [active] 1415167008074 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1415167008075 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1415167008076 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1415167008077 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1415167008078 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1415167008079 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1415167008080 Ligand binding site [chemical binding]; other site 1415167008081 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1415167008082 enoyl-CoA hydratase; Provisional; Region: PRK07658 1415167008083 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1415167008084 substrate binding site [chemical binding]; other site 1415167008085 oxyanion hole (OAH) forming residues; other site 1415167008086 trimer interface [polypeptide binding]; other site 1415167008087 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167008088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167008089 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1415167008090 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1415167008091 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1415167008092 acyl-activating enzyme (AAE) consensus motif; other site 1415167008093 putative AMP binding site [chemical binding]; other site 1415167008094 putative active site [active] 1415167008095 putative CoA binding site [chemical binding]; other site 1415167008096 Predicted membrane protein [Function unknown]; Region: COG3766 1415167008097 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1415167008098 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1415167008099 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1415167008100 MutS domain III; Region: MutS_III; pfam05192 1415167008101 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1415167008102 Walker A/P-loop; other site 1415167008103 ATP binding site [chemical binding]; other site 1415167008104 Q-loop/lid; other site 1415167008105 ABC transporter signature motif; other site 1415167008106 Walker B; other site 1415167008107 D-loop; other site 1415167008108 H-loop/switch region; other site 1415167008109 Smr domain; Region: Smr; pfam01713 1415167008110 hypothetical protein; Provisional; Region: PRK08609 1415167008111 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1415167008112 active site 1415167008113 primer binding site [nucleotide binding]; other site 1415167008114 NTP binding site [chemical binding]; other site 1415167008115 metal binding triad [ion binding]; metal-binding site 1415167008116 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1415167008117 active site 1415167008118 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1415167008119 Colicin V production protein; Region: Colicin_V; pfam02674 1415167008120 cell division protein ZapA; Provisional; Region: PRK14126 1415167008121 ribonuclease HIII; Provisional; Region: PRK00996 1415167008122 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1415167008123 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1415167008124 RNA/DNA hybrid binding site [nucleotide binding]; other site 1415167008125 active site 1415167008126 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1415167008127 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1415167008128 putative tRNA-binding site [nucleotide binding]; other site 1415167008129 B3/4 domain; Region: B3_4; pfam03483 1415167008130 tRNA synthetase B5 domain; Region: B5; smart00874 1415167008131 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1415167008132 dimer interface [polypeptide binding]; other site 1415167008133 motif 1; other site 1415167008134 motif 3; other site 1415167008135 motif 2; other site 1415167008136 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1415167008137 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1415167008138 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1415167008139 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1415167008140 dimer interface [polypeptide binding]; other site 1415167008141 motif 1; other site 1415167008142 active site 1415167008143 motif 2; other site 1415167008144 motif 3; other site 1415167008145 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1415167008146 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1415167008147 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1415167008148 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1415167008149 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1415167008150 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1415167008151 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1415167008152 FAD binding domain; Region: FAD_binding_4; pfam01565 1415167008153 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1415167008154 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1415167008155 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1415167008156 Cysteine-rich domain; Region: CCG; pfam02754 1415167008157 Cysteine-rich domain; Region: CCG; pfam02754 1415167008158 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1415167008159 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167008160 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1415167008161 Carbon starvation protein CstA; Region: CstA; pfam02554 1415167008162 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1415167008163 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1415167008164 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1415167008165 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1415167008166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167008167 putative PBP binding loops; other site 1415167008168 dimer interface [polypeptide binding]; other site 1415167008169 ABC-ATPase subunit interface; other site 1415167008170 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1415167008171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167008172 dimer interface [polypeptide binding]; other site 1415167008173 conserved gate region; other site 1415167008174 putative PBP binding loops; other site 1415167008175 ABC-ATPase subunit interface; other site 1415167008176 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1415167008177 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1415167008178 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1415167008179 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1415167008180 active site 1415167008181 metal binding site [ion binding]; metal-binding site 1415167008182 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1415167008183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167008184 active site 1415167008185 motif I; other site 1415167008186 motif II; other site 1415167008187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167008188 motif II; other site 1415167008189 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1415167008190 L-ribulose-5-phosphate 4-epimerase; Region: araD; TIGR00760 1415167008191 intersubunit interface [polypeptide binding]; other site 1415167008192 active site 1415167008193 Zn2+ binding site [ion binding]; other site 1415167008194 L-ribulokinase; Region: L-ribulokinase; TIGR01234 1415167008195 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1415167008196 N- and C-terminal domain interface [polypeptide binding]; other site 1415167008197 active site 1415167008198 MgATP binding site [chemical binding]; other site 1415167008199 catalytic site [active] 1415167008200 metal binding site [ion binding]; metal-binding site 1415167008201 carbohydrate binding site [chemical binding]; other site 1415167008202 homodimer interface [polypeptide binding]; other site 1415167008203 L-arabinose isomerase; Provisional; Region: PRK02929 1415167008204 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1415167008205 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1415167008206 trimer interface [polypeptide binding]; other site 1415167008207 putative substrate binding site [chemical binding]; other site 1415167008208 putative metal binding site [ion binding]; other site 1415167008209 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1415167008210 substrate binding site [chemical binding]; other site 1415167008211 active site 1415167008212 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1415167008213 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1415167008214 oligomer interface [polypeptide binding]; other site 1415167008215 active site 1415167008216 metal binding site [ion binding]; metal-binding site 1415167008217 Predicted membrane protein [Function unknown]; Region: COG3326 1415167008218 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1415167008219 23S rRNA binding site [nucleotide binding]; other site 1415167008220 L21 binding site [polypeptide binding]; other site 1415167008221 L13 binding site [polypeptide binding]; other site 1415167008222 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1415167008223 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1415167008224 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1415167008225 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1415167008226 antiholin-like protein LrgB; Provisional; Region: PRK04288 1415167008227 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1415167008228 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1415167008229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167008230 active site 1415167008231 phosphorylation site [posttranslational modification] 1415167008232 intermolecular recognition site; other site 1415167008233 dimerization interface [polypeptide binding]; other site 1415167008234 LytTr DNA-binding domain; Region: LytTR; pfam04397 1415167008235 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1415167008236 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1415167008237 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1415167008238 Histidine kinase; Region: His_kinase; pfam06580 1415167008239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167008240 ATP binding site [chemical binding]; other site 1415167008241 Mg2+ binding site [ion binding]; other site 1415167008242 G-X-G motif; other site 1415167008243 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1415167008244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167008245 motif II; other site 1415167008246 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1415167008247 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1415167008248 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1415167008249 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1415167008250 active site 1415167008251 dimer interface [polypeptide binding]; other site 1415167008252 motif 1; other site 1415167008253 motif 2; other site 1415167008254 motif 3; other site 1415167008255 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1415167008256 anticodon binding site; other site 1415167008257 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 1415167008258 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1415167008259 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1415167008260 primosomal protein DnaI; Reviewed; Region: PRK08939 1415167008261 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1415167008262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167008263 Walker A motif; other site 1415167008264 ATP binding site [chemical binding]; other site 1415167008265 Walker B motif; other site 1415167008266 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1415167008267 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1415167008268 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1415167008269 ATP cone domain; Region: ATP-cone; pfam03477 1415167008270 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1415167008271 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1415167008272 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1415167008273 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1415167008274 Predicted transcriptional regulators [Transcription]; Region: COG1733 1415167008275 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1415167008276 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1415167008277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167008278 putative substrate translocation pore; other site 1415167008279 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1415167008280 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1415167008281 active site 1415167008282 catalytic tetrad [active] 1415167008283 dephospho-CoA kinase; Region: TIGR00152 1415167008284 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1415167008285 CoA-binding site [chemical binding]; other site 1415167008286 ATP-binding [chemical binding]; other site 1415167008287 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1415167008288 Domain of unknown function DUF; Region: DUF204; pfam02659 1415167008289 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1415167008290 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1415167008291 DNA binding site [nucleotide binding] 1415167008292 catalytic residue [active] 1415167008293 H2TH interface [polypeptide binding]; other site 1415167008294 putative catalytic residues [active] 1415167008295 turnover-facilitating residue; other site 1415167008296 intercalation triad [nucleotide binding]; other site 1415167008297 8OG recognition residue [nucleotide binding]; other site 1415167008298 putative reading head residues; other site 1415167008299 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1415167008300 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1415167008301 DNA polymerase I; Provisional; Region: PRK05755 1415167008302 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1415167008303 active site 1415167008304 metal binding site 1 [ion binding]; metal-binding site 1415167008305 putative 5' ssDNA interaction site; other site 1415167008306 metal binding site 3; metal-binding site 1415167008307 metal binding site 2 [ion binding]; metal-binding site 1415167008308 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1415167008309 putative DNA binding site [nucleotide binding]; other site 1415167008310 putative metal binding site [ion binding]; other site 1415167008311 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1415167008312 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1415167008313 active site 1415167008314 DNA binding site [nucleotide binding] 1415167008315 catalytic site [active] 1415167008316 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1415167008317 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167008318 putative active site [active] 1415167008319 heme pocket [chemical binding]; other site 1415167008320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167008321 dimer interface [polypeptide binding]; other site 1415167008322 phosphorylation site [posttranslational modification] 1415167008323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167008324 ATP binding site [chemical binding]; other site 1415167008325 Mg2+ binding site [ion binding]; other site 1415167008326 G-X-G motif; other site 1415167008327 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1415167008328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167008329 active site 1415167008330 phosphorylation site [posttranslational modification] 1415167008331 intermolecular recognition site; other site 1415167008332 dimerization interface [polypeptide binding]; other site 1415167008333 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1415167008334 DNA binding site [nucleotide binding] 1415167008335 malate dehydrogenase; Reviewed; Region: PRK06223 1415167008336 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1415167008337 NAD(P) binding site [chemical binding]; other site 1415167008338 dimer interface [polypeptide binding]; other site 1415167008339 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1415167008340 substrate binding site [chemical binding]; other site 1415167008341 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1415167008342 isocitrate dehydrogenase; Validated; Region: PRK07362 1415167008343 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1415167008344 dimer interface [polypeptide binding]; other site 1415167008345 Citrate synthase; Region: Citrate_synt; pfam00285 1415167008346 active site 1415167008347 citrylCoA binding site [chemical binding]; other site 1415167008348 oxalacetate/citrate binding site [chemical binding]; other site 1415167008349 coenzyme A binding site [chemical binding]; other site 1415167008350 catalytic triad [active] 1415167008351 Predicted membrane protein [Function unknown]; Region: COG2707 1415167008352 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1415167008353 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1415167008354 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1415167008355 pyruvate kinase; Provisional; Region: PRK06354 1415167008356 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1415167008357 domain interfaces; other site 1415167008358 active site 1415167008359 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1415167008360 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1415167008361 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1415167008362 active site 1415167008363 ADP/pyrophosphate binding site [chemical binding]; other site 1415167008364 dimerization interface [polypeptide binding]; other site 1415167008365 allosteric effector site; other site 1415167008366 fructose-1,6-bisphosphate binding site; other site 1415167008367 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1415167008368 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1415167008369 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1415167008370 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1415167008371 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1415167008372 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1415167008373 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1415167008374 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1415167008375 putative NAD(P) binding site [chemical binding]; other site 1415167008376 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1415167008377 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1415167008378 active site 1415167008379 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1415167008380 generic binding surface I; other site 1415167008381 generic binding surface II; other site 1415167008382 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1415167008383 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1415167008384 DHH family; Region: DHH; pfam01368 1415167008385 DHHA1 domain; Region: DHHA1; pfam02272 1415167008386 YtpI-like protein; Region: YtpI; pfam14007 1415167008387 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1415167008388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167008389 DNA-binding site [nucleotide binding]; DNA binding site 1415167008390 DRTGG domain; Region: DRTGG; pfam07085 1415167008391 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1415167008392 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1415167008393 active site 2 [active] 1415167008394 active site 1 [active] 1415167008395 Predicted permeases [General function prediction only]; Region: COG0730 1415167008396 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1415167008397 amidohydrolase; Region: amidohydrolases; TIGR01891 1415167008398 metal binding site [ion binding]; metal-binding site 1415167008399 dimer interface [polypeptide binding]; other site 1415167008400 Riboflavin kinase; Region: Flavokinase; pfam01687 1415167008401 Riboflavin kinase; Region: Flavokinase; smart00904 1415167008402 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1415167008403 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1415167008404 active site 1415167008405 non-prolyl cis peptide bond; other site 1415167008406 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1415167008407 catalytic residues [active] 1415167008408 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1415167008409 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1415167008410 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1415167008411 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1415167008412 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1415167008413 Walker A/P-loop; other site 1415167008414 ATP binding site [chemical binding]; other site 1415167008415 Q-loop/lid; other site 1415167008416 ABC transporter signature motif; other site 1415167008417 Walker B; other site 1415167008418 D-loop; other site 1415167008419 H-loop/switch region; other site 1415167008420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167008421 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1415167008422 dimer interface [polypeptide binding]; other site 1415167008423 conserved gate region; other site 1415167008424 putative PBP binding loops; other site 1415167008425 ABC-ATPase subunit interface; other site 1415167008426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167008427 dimer interface [polypeptide binding]; other site 1415167008428 conserved gate region; other site 1415167008429 putative PBP binding loops; other site 1415167008430 ABC-ATPase subunit interface; other site 1415167008431 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1415167008432 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1415167008433 substrate binding pocket [chemical binding]; other site 1415167008434 membrane-bound complex binding site; other site 1415167008435 hinge residues; other site 1415167008436 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1415167008437 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1415167008438 substrate binding pocket [chemical binding]; other site 1415167008439 membrane-bound complex binding site; other site 1415167008440 hinge residues; other site 1415167008441 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1415167008442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167008443 Coenzyme A binding pocket [chemical binding]; other site 1415167008444 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167008445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167008446 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1415167008447 dimerization interface [polypeptide binding]; other site 1415167008448 metal-dependent hydrolase; Provisional; Region: PRK00685 1415167008449 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1415167008450 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1415167008451 classical (c) SDRs; Region: SDR_c; cd05233 1415167008452 NAD(P) binding site [chemical binding]; other site 1415167008453 active site 1415167008454 argininosuccinate lyase; Provisional; Region: PRK00855 1415167008455 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1415167008456 active sites [active] 1415167008457 tetramer interface [polypeptide binding]; other site 1415167008458 argininosuccinate synthase; Provisional; Region: PRK13820 1415167008459 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1415167008460 ANP binding site [chemical binding]; other site 1415167008461 Substrate Binding Site II [chemical binding]; other site 1415167008462 Substrate Binding Site I [chemical binding]; other site 1415167008463 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1415167008464 MPT binding site; other site 1415167008465 trimer interface [polypeptide binding]; other site 1415167008466 propionate/acetate kinase; Provisional; Region: PRK12379 1415167008467 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1415167008468 nucleotide binding site [chemical binding]; other site 1415167008469 butyrate kinase; Provisional; Region: PRK03011 1415167008470 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1415167008471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167008472 S-adenosylmethionine binding site [chemical binding]; other site 1415167008473 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1415167008474 dimer interface [polypeptide binding]; other site 1415167008475 catalytic triad [active] 1415167008476 peroxidatic and resolving cysteines [active] 1415167008477 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1415167008478 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1415167008479 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1415167008480 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1415167008481 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1415167008482 tandem repeat interface [polypeptide binding]; other site 1415167008483 oligomer interface [polypeptide binding]; other site 1415167008484 active site residues [active] 1415167008485 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1415167008486 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1415167008487 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1415167008488 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1415167008489 active site 1415167008490 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1415167008491 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1415167008492 active site 1415167008493 acyl-activating enzyme (AAE) consensus motif; other site 1415167008494 putative CoA binding site [chemical binding]; other site 1415167008495 AMP binding site [chemical binding]; other site 1415167008496 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1415167008497 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1415167008498 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1415167008499 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1415167008500 Ligand Binding Site [chemical binding]; other site 1415167008501 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1415167008502 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1415167008503 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1415167008504 catalytic residue [active] 1415167008505 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1415167008506 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1415167008507 histidinol-phosphatase; Reviewed; Region: PRK08123 1415167008508 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1415167008509 active site 1415167008510 dimer interface [polypeptide binding]; other site 1415167008511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167008512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167008513 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1415167008514 GAF domain; Region: GAF_2; pfam13185 1415167008515 GAF domain; Region: GAF; cl17456 1415167008516 GAF domain; Region: GAF_3; pfam13492 1415167008517 GAF domain; Region: GAF_2; pfam13185 1415167008518 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1415167008519 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1415167008520 metal binding site [ion binding]; metal-binding site 1415167008521 active site 1415167008522 I-site; other site 1415167008523 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1415167008524 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1415167008525 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1415167008526 RNA binding surface [nucleotide binding]; other site 1415167008527 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1415167008528 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1415167008529 active site 1415167008530 HIGH motif; other site 1415167008531 dimer interface [polypeptide binding]; other site 1415167008532 KMSKS motif; other site 1415167008533 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1415167008534 RNA binding surface [nucleotide binding]; other site 1415167008535 acetyl-CoA synthetase; Provisional; Region: PRK04319 1415167008536 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1415167008537 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1415167008538 active site 1415167008539 acyl-activating enzyme (AAE) consensus motif; other site 1415167008540 putative CoA binding site [chemical binding]; other site 1415167008541 AMP binding site [chemical binding]; other site 1415167008542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167008543 Coenzyme A binding pocket [chemical binding]; other site 1415167008544 FOG: CBS domain [General function prediction only]; Region: COG0517 1415167008545 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1415167008546 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1415167008547 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1415167008548 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1415167008549 active site 1415167008550 Zn binding site [ion binding]; other site 1415167008551 flagellar motor protein MotS; Reviewed; Region: PRK06925 1415167008552 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1415167008553 ligand binding site [chemical binding]; other site 1415167008554 flagellar motor protein MotP; Reviewed; Region: PRK06926 1415167008555 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1415167008556 catabolite control protein A; Region: ccpA; TIGR01481 1415167008557 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1415167008558 DNA binding site [nucleotide binding] 1415167008559 domain linker motif; other site 1415167008560 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1415167008561 dimerization interface [polypeptide binding]; other site 1415167008562 effector binding site; other site 1415167008563 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1415167008564 chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801 1415167008565 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1415167008566 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1415167008567 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1415167008568 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1415167008569 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1415167008570 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1415167008571 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1415167008572 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1415167008573 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1415167008574 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1415167008575 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1415167008576 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1415167008577 putative tRNA-binding site [nucleotide binding]; other site 1415167008578 hypothetical protein; Provisional; Region: PRK13668 1415167008579 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1415167008580 catalytic residues [active] 1415167008581 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1415167008582 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1415167008583 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1415167008584 oligomer interface [polypeptide binding]; other site 1415167008585 active site 1415167008586 metal binding site [ion binding]; metal-binding site 1415167008587 Predicted small secreted protein [Function unknown]; Region: COG5584 1415167008588 malate dehydrogenase; Provisional; Region: PRK13529 1415167008589 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1415167008590 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1415167008591 NAD(P) binding site [chemical binding]; other site 1415167008592 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1415167008593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167008594 S-adenosylmethionine binding site [chemical binding]; other site 1415167008595 YtzH-like protein; Region: YtzH; pfam14165 1415167008596 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1415167008597 active site 1415167008598 ATP binding site [chemical binding]; other site 1415167008599 Phosphotransferase enzyme family; Region: APH; pfam01636 1415167008600 substrate binding site [chemical binding]; other site 1415167008601 pullulanase, type I; Region: pulA_typeI; TIGR02104 1415167008602 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1415167008603 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1415167008604 Ca binding site [ion binding]; other site 1415167008605 active site 1415167008606 catalytic site [active] 1415167008607 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1415167008608 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1415167008609 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1415167008610 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1415167008611 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1415167008612 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1415167008613 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1415167008614 dimer interface [polypeptide binding]; other site 1415167008615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167008616 catalytic residue [active] 1415167008617 dipeptidase PepV; Reviewed; Region: PRK07318 1415167008618 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1415167008619 active site 1415167008620 metal binding site [ion binding]; metal-binding site 1415167008621 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1415167008622 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1415167008623 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1415167008624 Walker A/P-loop; other site 1415167008625 ATP binding site [chemical binding]; other site 1415167008626 Q-loop/lid; other site 1415167008627 ABC transporter signature motif; other site 1415167008628 Walker B; other site 1415167008629 D-loop; other site 1415167008630 H-loop/switch region; other site 1415167008631 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1415167008632 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1415167008633 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1415167008634 RNA binding surface [nucleotide binding]; other site 1415167008635 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1415167008636 active site 1415167008637 uracil binding [chemical binding]; other site 1415167008638 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1415167008639 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1415167008640 Predicted flavoproteins [General function prediction only]; Region: COG2081 1415167008641 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1415167008642 BCCT family transporter; Region: BCCT; pfam02028 1415167008643 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1415167008644 Predicted integral membrane protein [Function unknown]; Region: COG5578 1415167008645 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1415167008646 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1415167008647 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1415167008648 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1415167008649 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1415167008650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167008651 dimer interface [polypeptide binding]; other site 1415167008652 conserved gate region; other site 1415167008653 ABC-ATPase subunit interface; other site 1415167008654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167008655 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1415167008656 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1415167008657 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1415167008658 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1415167008659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167008660 dimer interface [polypeptide binding]; other site 1415167008661 conserved gate region; other site 1415167008662 putative PBP binding loops; other site 1415167008663 ABC-ATPase subunit interface; other site 1415167008664 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1415167008665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1415167008666 NAD(P) binding site [chemical binding]; other site 1415167008667 active site 1415167008668 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1415167008669 Cytochrome P450; Region: p450; cl12078 1415167008670 biotin synthase; Validated; Region: PRK06256 1415167008671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167008672 FeS/SAM binding site; other site 1415167008673 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1415167008674 AAA domain; Region: AAA_26; pfam13500 1415167008675 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1415167008676 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1415167008677 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1415167008678 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1415167008679 substrate-cofactor binding pocket; other site 1415167008680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167008681 catalytic residue [active] 1415167008682 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1415167008683 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1415167008684 inhibitor-cofactor binding pocket; inhibition site 1415167008685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167008686 catalytic residue [active] 1415167008687 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1415167008688 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1415167008689 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1415167008690 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1415167008691 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1415167008692 DNA binding site [nucleotide binding] 1415167008693 domain linker motif; other site 1415167008694 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1415167008695 putative ligand binding site [chemical binding]; other site 1415167008696 putative dimerization interface [polypeptide binding]; other site 1415167008697 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1415167008698 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1415167008699 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1415167008700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167008701 dimer interface [polypeptide binding]; other site 1415167008702 conserved gate region; other site 1415167008703 putative PBP binding loops; other site 1415167008704 ABC-ATPase subunit interface; other site 1415167008705 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1415167008706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167008707 dimer interface [polypeptide binding]; other site 1415167008708 conserved gate region; other site 1415167008709 putative PBP binding loops; other site 1415167008710 ABC-ATPase subunit interface; other site 1415167008711 alpha-galactosidase; Provisional; Region: PRK15076 1415167008712 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1415167008713 NAD binding site [chemical binding]; other site 1415167008714 sugar binding site [chemical binding]; other site 1415167008715 divalent metal binding site [ion binding]; other site 1415167008716 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1415167008717 dimer interface [polypeptide binding]; other site 1415167008718 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1415167008719 active site residue [active] 1415167008720 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1415167008721 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1415167008722 HIGH motif; other site 1415167008723 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1415167008724 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1415167008725 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1415167008726 active site 1415167008727 KMSKS motif; other site 1415167008728 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1415167008729 tRNA binding surface [nucleotide binding]; other site 1415167008730 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1415167008731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167008732 PAS domain; Region: PAS_9; pfam13426 1415167008733 putative active site [active] 1415167008734 heme pocket [chemical binding]; other site 1415167008735 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1415167008736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167008737 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167008738 putative substrate translocation pore; other site 1415167008739 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1415167008740 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1415167008741 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1415167008742 FtsX-like permease family; Region: FtsX; pfam02687 1415167008743 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1415167008744 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1415167008745 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1415167008746 Walker A/P-loop; other site 1415167008747 ATP binding site [chemical binding]; other site 1415167008748 Q-loop/lid; other site 1415167008749 ABC transporter signature motif; other site 1415167008750 Walker B; other site 1415167008751 D-loop; other site 1415167008752 H-loop/switch region; other site 1415167008753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1415167008754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167008755 ATP binding site [chemical binding]; other site 1415167008756 Mg2+ binding site [ion binding]; other site 1415167008757 G-X-G motif; other site 1415167008758 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1415167008759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167008760 active site 1415167008761 phosphorylation site [posttranslational modification] 1415167008762 intermolecular recognition site; other site 1415167008763 dimerization interface [polypeptide binding]; other site 1415167008764 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1415167008765 DNA binding site [nucleotide binding] 1415167008766 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1415167008767 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1415167008768 FtsX-like permease family; Region: FtsX; pfam02687 1415167008769 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1415167008770 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1415167008771 Walker A/P-loop; other site 1415167008772 ATP binding site [chemical binding]; other site 1415167008773 Q-loop/lid; other site 1415167008774 ABC transporter signature motif; other site 1415167008775 Walker B; other site 1415167008776 D-loop; other site 1415167008777 H-loop/switch region; other site 1415167008778 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1415167008779 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1415167008780 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1415167008781 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1415167008782 Walker A/P-loop; other site 1415167008783 ATP binding site [chemical binding]; other site 1415167008784 Q-loop/lid; other site 1415167008785 ABC transporter signature motif; other site 1415167008786 Walker B; other site 1415167008787 D-loop; other site 1415167008788 H-loop/switch region; other site 1415167008789 Predicted transcriptional regulators [Transcription]; Region: COG1725 1415167008790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167008791 DNA-binding site [nucleotide binding]; DNA binding site 1415167008792 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1415167008793 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1415167008794 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1415167008795 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1415167008796 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1415167008797 PGAP1-like protein; Region: PGAP1; pfam07819 1415167008798 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1415167008799 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1415167008800 trimer interface [polypeptide binding]; other site 1415167008801 putative metal binding site [ion binding]; other site 1415167008802 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1415167008803 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1415167008804 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1415167008805 active site 1415167008806 dimer interface [polypeptide binding]; other site 1415167008807 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1415167008808 Ligand Binding Site [chemical binding]; other site 1415167008809 Molecular Tunnel; other site 1415167008810 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1415167008811 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1415167008812 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1415167008813 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1415167008814 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1415167008815 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1415167008816 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1415167008817 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1415167008818 NMT1-like family; Region: NMT1_2; pfam13379 1415167008819 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1415167008820 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1415167008821 Walker A/P-loop; other site 1415167008822 ATP binding site [chemical binding]; other site 1415167008823 Q-loop/lid; other site 1415167008824 ABC transporter signature motif; other site 1415167008825 Walker B; other site 1415167008826 D-loop; other site 1415167008827 H-loop/switch region; other site 1415167008828 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1415167008829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167008830 dimer interface [polypeptide binding]; other site 1415167008831 conserved gate region; other site 1415167008832 putative PBP binding loops; other site 1415167008833 ABC-ATPase subunit interface; other site 1415167008834 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1415167008835 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1415167008836 nudix motif; other site 1415167008837 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1415167008838 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1415167008839 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1415167008840 dimerization interface [polypeptide binding]; other site 1415167008841 DPS ferroxidase diiron center [ion binding]; other site 1415167008842 ion pore; other site 1415167008843 YtkA-like; Region: YtkA; pfam13115 1415167008844 S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664 1415167008845 Haemolytic domain; Region: Haemolytic; pfam01809 1415167008846 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1415167008847 active site clefts [active] 1415167008848 zinc binding site [ion binding]; other site 1415167008849 dimer interface [polypeptide binding]; other site 1415167008850 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1415167008851 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1415167008852 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1415167008853 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1415167008854 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1415167008855 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167008856 ABC-ATPase subunit interface; other site 1415167008857 dimer interface [polypeptide binding]; other site 1415167008858 putative PBP binding regions; other site 1415167008859 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1415167008860 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167008861 ABC-ATPase subunit interface; other site 1415167008862 dimer interface [polypeptide binding]; other site 1415167008863 putative PBP binding regions; other site 1415167008864 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1415167008865 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1415167008866 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1415167008867 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1415167008868 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 1415167008869 metal binding site [ion binding]; metal-binding site 1415167008870 intersubunit interface [polypeptide binding]; other site 1415167008871 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1415167008872 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1415167008873 active site 1415167008874 octamer interface [polypeptide binding]; other site 1415167008875 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1415167008876 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1415167008877 acyl-activating enzyme (AAE) consensus motif; other site 1415167008878 putative AMP binding site [chemical binding]; other site 1415167008879 putative active site [active] 1415167008880 putative CoA binding site [chemical binding]; other site 1415167008881 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1415167008882 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1415167008883 substrate binding site [chemical binding]; other site 1415167008884 oxyanion hole (OAH) forming residues; other site 1415167008885 trimer interface [polypeptide binding]; other site 1415167008886 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1415167008887 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1415167008888 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1415167008889 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1415167008890 dimer interface [polypeptide binding]; other site 1415167008891 tetramer interface [polypeptide binding]; other site 1415167008892 PYR/PP interface [polypeptide binding]; other site 1415167008893 TPP binding site [chemical binding]; other site 1415167008894 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1415167008895 TPP-binding site; other site 1415167008896 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1415167008897 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1415167008898 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 1415167008899 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1415167008900 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1415167008901 active site 1415167008902 tetramer interface; other site 1415167008903 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1415167008904 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1415167008905 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1415167008906 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1415167008907 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1415167008908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1415167008909 NAD(P) binding site [chemical binding]; other site 1415167008910 active site 1415167008911 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1415167008912 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1415167008913 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1415167008914 spore coat protein YutH; Region: spore_yutH; TIGR02905 1415167008915 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1415167008916 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1415167008917 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1415167008918 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1415167008919 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 1415167008920 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1415167008921 homodimer interface [polypeptide binding]; other site 1415167008922 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1415167008923 active site pocket [active] 1415167008924 glycogen synthase; Provisional; Region: glgA; PRK00654 1415167008925 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1415167008926 ADP-binding pocket [chemical binding]; other site 1415167008927 homodimer interface [polypeptide binding]; other site 1415167008928 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1415167008929 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1415167008930 ligand binding site; other site 1415167008931 oligomer interface; other site 1415167008932 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1415167008933 dimer interface [polypeptide binding]; other site 1415167008934 N-terminal domain interface [polypeptide binding]; other site 1415167008935 sulfate 1 binding site; other site 1415167008936 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1415167008937 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1415167008938 ligand binding site; other site 1415167008939 oligomer interface; other site 1415167008940 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1415167008941 dimer interface [polypeptide binding]; other site 1415167008942 N-terminal domain interface [polypeptide binding]; other site 1415167008943 sulfate 1 binding site; other site 1415167008944 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 1415167008945 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1415167008946 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1415167008947 active site 1415167008948 catalytic site [active] 1415167008949 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1415167008950 Predicted membrane protein [Function unknown]; Region: COG3859 1415167008951 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1415167008952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167008953 Coenzyme A binding pocket [chemical binding]; other site 1415167008954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1415167008955 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1415167008956 DinB superfamily; Region: DinB_2; pfam12867 1415167008957 MOSC domain; Region: MOSC; pfam03473 1415167008958 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1415167008959 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1415167008960 active site 1415167008961 NAD binding site [chemical binding]; other site 1415167008962 metal binding site [ion binding]; metal-binding site 1415167008963 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1415167008964 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1415167008965 tetramerization interface [polypeptide binding]; other site 1415167008966 NAD(P) binding site [chemical binding]; other site 1415167008967 catalytic residues [active] 1415167008968 Predicted transcriptional regulators [Transcription]; Region: COG1510 1415167008969 MarR family; Region: MarR_2; pfam12802 1415167008970 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1415167008971 TrkA-N domain; Region: TrkA_N; pfam02254 1415167008972 TrkA-C domain; Region: TrkA_C; pfam02080 1415167008973 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1415167008974 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1415167008975 Predicted membrane protein [Function unknown]; Region: COG4682 1415167008976 yiaA/B two helix domain; Region: YiaAB; pfam05360 1415167008977 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1415167008978 SH3-like domain; Region: SH3_8; pfam13457 1415167008979 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167008980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167008981 putative substrate translocation pore; other site 1415167008982 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1415167008983 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1415167008984 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1415167008985 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1415167008986 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1415167008987 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1415167008988 L-rhamnose isomerase (RhaA); Region: RhaA; pfam06134 1415167008989 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1415167008990 Domain of unknown function (DUF718); Region: DUF718; cl01281 1415167008991 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1415167008992 N- and C-terminal domain interface [polypeptide binding]; other site 1415167008993 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1415167008994 active site 1415167008995 putative catalytic site [active] 1415167008996 metal binding site [ion binding]; metal-binding site 1415167008997 ATP binding site [chemical binding]; other site 1415167008998 carbohydrate binding site [chemical binding]; other site 1415167008999 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1415167009000 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1415167009001 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1415167009002 short chain dehydrogenase; Validated; Region: PRK08324 1415167009003 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1415167009004 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1415167009005 putative NAD(P) binding site [chemical binding]; other site 1415167009006 active site 1415167009007 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1415167009008 Cache domain; Region: Cache_1; pfam02743 1415167009009 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167009010 dimerization interface [polypeptide binding]; other site 1415167009011 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1415167009012 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1415167009013 dimer interface [polypeptide binding]; other site 1415167009014 putative CheW interface [polypeptide binding]; other site 1415167009015 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1415167009016 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1415167009017 Cache domain; Region: Cache_1; pfam02743 1415167009018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167009019 dimerization interface [polypeptide binding]; other site 1415167009020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1415167009021 dimer interface [polypeptide binding]; other site 1415167009022 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1415167009023 putative CheW interface [polypeptide binding]; other site 1415167009024 Tar ligand binding domain homologue; Region: TarH; pfam02203 1415167009025 Cache domain; Region: Cache_1; pfam02743 1415167009026 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1415167009027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167009028 dimerization interface [polypeptide binding]; other site 1415167009029 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1415167009030 dimer interface [polypeptide binding]; other site 1415167009031 putative CheW interface [polypeptide binding]; other site 1415167009032 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1415167009033 Cache domain; Region: Cache_1; pfam02743 1415167009034 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167009035 dimerization interface [polypeptide binding]; other site 1415167009036 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1415167009037 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1415167009038 dimer interface [polypeptide binding]; other site 1415167009039 putative CheW interface [polypeptide binding]; other site 1415167009040 transglutaminase; Provisional; Region: tgl; PRK03187 1415167009041 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1415167009042 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1415167009043 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1415167009044 Ca binding site [ion binding]; other site 1415167009045 active site 1415167009046 catalytic site [active] 1415167009047 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1415167009048 Domain of unknown function DUF21; Region: DUF21; pfam01595 1415167009049 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1415167009050 Transporter associated domain; Region: CorC_HlyC; smart01091 1415167009051 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1415167009052 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1415167009053 Ion channel; Region: Ion_trans_2; pfam07885 1415167009054 TrkA-N domain; Region: TrkA_N; pfam02254 1415167009055 YugN-like family; Region: YugN; pfam08868 1415167009056 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1415167009057 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1415167009058 active site 1415167009059 dimer interface [polypeptide binding]; other site 1415167009060 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1415167009061 dimer interface [polypeptide binding]; other site 1415167009062 active site 1415167009063 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1415167009064 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1415167009065 dimer interface [polypeptide binding]; other site 1415167009066 active site 1415167009067 metal binding site [ion binding]; metal-binding site 1415167009068 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1415167009069 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1415167009070 dimer interface [polypeptide binding]; other site 1415167009071 active site 1415167009072 metal binding site [ion binding]; metal-binding site 1415167009073 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1415167009074 general stress protein 13; Validated; Region: PRK08059 1415167009075 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1415167009076 RNA binding site [nucleotide binding]; other site 1415167009077 hypothetical protein; Validated; Region: PRK07682 1415167009078 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167009079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167009080 homodimer interface [polypeptide binding]; other site 1415167009081 catalytic residue [active] 1415167009082 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1415167009083 AsnC family; Region: AsnC_trans_reg; pfam01037 1415167009084 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1415167009085 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1415167009086 nucleophilic elbow; other site 1415167009087 catalytic triad; other site 1415167009088 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1415167009089 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1415167009090 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167009091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167009092 homodimer interface [polypeptide binding]; other site 1415167009093 catalytic residue [active] 1415167009094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1415167009095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167009096 dimer interface [polypeptide binding]; other site 1415167009097 phosphorylation site [posttranslational modification] 1415167009098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167009099 ATP binding site [chemical binding]; other site 1415167009100 Mg2+ binding site [ion binding]; other site 1415167009101 G-X-G motif; other site 1415167009102 Kinase associated protein B; Region: KapB; pfam08810 1415167009103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167009104 putative substrate translocation pore; other site 1415167009105 Transglycosylase; Region: Transgly; pfam00912 1415167009106 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1415167009107 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1415167009108 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1415167009109 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1415167009110 PAS domain; Region: PAS; smart00091 1415167009111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167009112 ATP binding site [chemical binding]; other site 1415167009113 G-X-G motif; other site 1415167009114 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1415167009115 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1415167009116 ligand binding site [chemical binding]; other site 1415167009117 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1415167009118 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1415167009119 Walker A/P-loop; other site 1415167009120 ATP binding site [chemical binding]; other site 1415167009121 Q-loop/lid; other site 1415167009122 ABC transporter signature motif; other site 1415167009123 Walker B; other site 1415167009124 D-loop; other site 1415167009125 H-loop/switch region; other site 1415167009126 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1415167009127 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1415167009128 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1415167009129 TM-ABC transporter signature motif; other site 1415167009130 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1415167009131 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1415167009132 TM-ABC transporter signature motif; other site 1415167009133 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1415167009134 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1415167009135 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1415167009136 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1415167009137 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1415167009138 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1415167009139 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1415167009140 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1415167009141 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1415167009142 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1415167009143 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1415167009144 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1415167009145 CoenzymeA binding site [chemical binding]; other site 1415167009146 subunit interaction site [polypeptide binding]; other site 1415167009147 PHB binding site; other site 1415167009148 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1415167009149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167009150 active site 1415167009151 phosphorylation site [posttranslational modification] 1415167009152 intermolecular recognition site; other site 1415167009153 dimerization interface [polypeptide binding]; other site 1415167009154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1415167009155 DNA binding residues [nucleotide binding] 1415167009156 dimerization interface [polypeptide binding]; other site 1415167009157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1415167009158 Histidine kinase; Region: HisKA_3; pfam07730 1415167009159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167009160 ATP binding site [chemical binding]; other site 1415167009161 Mg2+ binding site [ion binding]; other site 1415167009162 G-X-G motif; other site 1415167009163 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1415167009164 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1415167009165 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1415167009166 substrate binding pocket [chemical binding]; other site 1415167009167 substrate-Mg2+ binding site; other site 1415167009168 aspartate-rich region 1; other site 1415167009169 DegQ (SacQ) family; Region: DegQ; pfam08181 1415167009170 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1415167009171 EAL domain; Region: EAL; pfam00563 1415167009172 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1415167009173 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1415167009174 active site 1415167009175 Isochorismatase family; Region: Isochorismatase; pfam00857 1415167009176 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1415167009177 catalytic triad [active] 1415167009178 conserved cis-peptide bond; other site 1415167009179 Uncharacterized conserved protein [Function unknown]; Region: COG5506 1415167009180 YueH-like protein; Region: YueH; pfam14166 1415167009181 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1415167009182 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1415167009183 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1415167009184 Uncharacterized conserved small protein [Function unknown]; Region: COG5428 1415167009185 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1415167009186 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1415167009187 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1415167009188 Zn2+ binding site [ion binding]; other site 1415167009189 Mg2+ binding site [ion binding]; other site 1415167009190 short chain dehydrogenase; Provisional; Region: PRK06924 1415167009191 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1415167009192 NADP binding site [chemical binding]; other site 1415167009193 homodimer interface [polypeptide binding]; other site 1415167009194 active site 1415167009195 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1415167009196 Predicted membrane protein [Function unknown]; Region: COG1511 1415167009197 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1415167009198 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1415167009199 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 1415167009200 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1415167009201 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1415167009202 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1415167009203 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1415167009204 Domain of unknown function DUF87; Region: DUF87; pfam01935 1415167009205 Predicted membrane protein [Function unknown]; Region: COG4499 1415167009206 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1415167009207 Uncharacterized small protein [Function unknown]; Region: COG5417 1415167009208 Ubiquitin homologues; Region: UBQ; smart00213 1415167009209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1415167009210 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1415167009211 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1415167009212 alanine dehydrogenase; Region: alaDH; TIGR00518 1415167009213 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1415167009214 hexamer interface [polypeptide binding]; other site 1415167009215 ligand binding site [chemical binding]; other site 1415167009216 putative active site [active] 1415167009217 NAD(P) binding site [chemical binding]; other site 1415167009218 Uncharacterized conserved protein [Function unknown]; Region: COG5634 1415167009219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1415167009220 Condensation domain; Region: Condensation; pfam00668 1415167009221 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1415167009222 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1415167009223 acyl-activating enzyme (AAE) consensus motif; other site 1415167009224 AMP binding site [chemical binding]; other site 1415167009225 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167009226 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1415167009227 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1415167009228 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1415167009229 acyl-activating enzyme (AAE) consensus motif; other site 1415167009230 AMP binding site [chemical binding]; other site 1415167009231 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1415167009232 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1415167009233 hydrophobic substrate binding pocket; other site 1415167009234 Isochorismatase family; Region: Isochorismatase; pfam00857 1415167009235 active site 1415167009236 conserved cis-peptide bond; other site 1415167009237 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1415167009238 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 1415167009239 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1415167009240 acyl-activating enzyme (AAE) consensus motif; other site 1415167009241 active site 1415167009242 AMP binding site [chemical binding]; other site 1415167009243 substrate binding site [chemical binding]; other site 1415167009244 isochorismate synthase DhbC; Validated; Region: PRK06923 1415167009245 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1415167009246 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1415167009247 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1415167009248 putative NAD(P) binding site [chemical binding]; other site 1415167009249 active site 1415167009250 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1415167009251 Putative esterase; Region: Esterase; pfam00756 1415167009252 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1415167009253 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1415167009254 Moco binding site; other site 1415167009255 metal coordination site [ion binding]; other site 1415167009256 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1415167009257 Predicted permease [General function prediction only]; Region: COG2056 1415167009258 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1415167009259 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1415167009260 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1415167009261 interface (dimer of trimers) [polypeptide binding]; other site 1415167009262 Substrate-binding/catalytic site; other site 1415167009263 Zn-binding sites [ion binding]; other site 1415167009264 Divergent PAP2 family; Region: DUF212; pfam02681 1415167009265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1415167009266 Putative membrane protein; Region: YuiB; pfam14068 1415167009267 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 1415167009268 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1415167009269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1415167009270 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1415167009271 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1415167009272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1415167009273 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1415167009274 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1415167009275 active site 1415167009276 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 1415167009277 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1415167009278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167009279 Coenzyme A binding pocket [chemical binding]; other site 1415167009280 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1415167009281 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1415167009282 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1415167009283 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1415167009284 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1415167009285 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1415167009286 Nucleoside recognition; Region: Gate; pfam07670 1415167009287 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1415167009288 hypothetical protein; Provisional; Region: PRK13669 1415167009289 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1415167009290 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1415167009291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1415167009292 NifU-like domain; Region: NifU; pfam01106 1415167009293 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1415167009294 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1415167009295 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1415167009296 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1415167009297 homoserine kinase; Region: thrB; TIGR00191 1415167009298 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1415167009299 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1415167009300 threonine synthase; Reviewed; Region: PRK06721 1415167009301 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1415167009302 homodimer interface [polypeptide binding]; other site 1415167009303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167009304 catalytic residue [active] 1415167009305 homoserine dehydrogenase; Provisional; Region: PRK06349 1415167009306 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1415167009307 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1415167009308 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1415167009309 spore coat protein YutH; Region: spore_yutH; TIGR02905 1415167009310 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1415167009311 tetramer interfaces [polypeptide binding]; other site 1415167009312 binuclear metal-binding site [ion binding]; other site 1415167009313 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1415167009314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167009315 active site 1415167009316 motif I; other site 1415167009317 motif II; other site 1415167009318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167009319 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1415167009320 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1415167009321 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1415167009322 lipoyl synthase; Provisional; Region: PRK05481 1415167009323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167009324 FeS/SAM binding site; other site 1415167009325 sporulation protein YunB; Region: spo_yunB; TIGR02832 1415167009326 Uncharacterized conserved protein [Function unknown]; Region: COG3377 1415167009327 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1415167009328 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1415167009329 active site 1415167009330 metal binding site [ion binding]; metal-binding site 1415167009331 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1415167009332 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1415167009333 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1415167009334 allantoinase; Provisional; Region: PRK06189 1415167009335 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1415167009336 active site 1415167009337 DRTGG domain; Region: DRTGG; pfam07085 1415167009338 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1415167009339 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1415167009340 xanthine permease; Region: pbuX; TIGR03173 1415167009341 xanthine permease; Region: pbuX; TIGR03173 1415167009342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1415167009343 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 1415167009344 Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the...; Region: Uricase; cd00445 1415167009345 tetramer interface [polypeptide binding]; other site 1415167009346 active site 1415167009347 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cd05469 1415167009348 active site 1415167009349 homotetramer interface [polypeptide binding]; other site 1415167009350 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 1415167009351 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1415167009352 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1415167009353 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1415167009354 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1415167009355 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1415167009356 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 1415167009357 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1415167009358 Ligand binding site; other site 1415167009359 metal-binding site 1415167009360 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1415167009361 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1415167009362 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1415167009363 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1415167009364 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1415167009365 catalytic residue [active] 1415167009366 allantoate amidohydrolase; Reviewed; Region: PRK09290 1415167009367 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1415167009368 active site 1415167009369 metal binding site [ion binding]; metal-binding site 1415167009370 dimer interface [polypeptide binding]; other site 1415167009371 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1415167009372 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1415167009373 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1415167009374 Walker A/P-loop; other site 1415167009375 ATP binding site [chemical binding]; other site 1415167009376 Q-loop/lid; other site 1415167009377 ABC transporter signature motif; other site 1415167009378 Walker B; other site 1415167009379 D-loop; other site 1415167009380 H-loop/switch region; other site 1415167009381 TOBE domain; Region: TOBE_2; pfam08402 1415167009382 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1415167009383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167009384 DNA-binding site [nucleotide binding]; DNA binding site 1415167009385 UTRA domain; Region: UTRA; pfam07702 1415167009386 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1415167009387 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1415167009388 substrate binding site [chemical binding]; other site 1415167009389 ATP binding site [chemical binding]; other site 1415167009390 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1415167009391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167009392 dimer interface [polypeptide binding]; other site 1415167009393 conserved gate region; other site 1415167009394 putative PBP binding loops; other site 1415167009395 ABC-ATPase subunit interface; other site 1415167009396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167009397 dimer interface [polypeptide binding]; other site 1415167009398 conserved gate region; other site 1415167009399 putative PBP binding loops; other site 1415167009400 ABC-ATPase subunit interface; other site 1415167009401 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1415167009402 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1415167009403 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1415167009404 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1415167009405 putative active site [active] 1415167009406 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1415167009407 dimer interface [polypeptide binding]; other site 1415167009408 active site 1415167009409 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 1415167009410 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1415167009411 GIY-YIG motif/motif A; other site 1415167009412 active site 1415167009413 catalytic site [active] 1415167009414 putative DNA binding site [nucleotide binding]; other site 1415167009415 metal binding site [ion binding]; metal-binding site 1415167009416 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1415167009417 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1415167009418 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167009419 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1415167009420 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1415167009421 FeS assembly protein SufB; Region: sufB; TIGR01980 1415167009422 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1415167009423 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1415167009424 trimerization site [polypeptide binding]; other site 1415167009425 active site 1415167009426 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1415167009427 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1415167009428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1415167009429 catalytic residue [active] 1415167009430 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1415167009431 FeS assembly protein SufD; Region: sufD; TIGR01981 1415167009432 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1415167009433 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1415167009434 Walker A/P-loop; other site 1415167009435 ATP binding site [chemical binding]; other site 1415167009436 Q-loop/lid; other site 1415167009437 ABC transporter signature motif; other site 1415167009438 Walker B; other site 1415167009439 D-loop; other site 1415167009440 H-loop/switch region; other site 1415167009441 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1415167009442 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1415167009443 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1415167009444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167009445 conserved gate region; other site 1415167009446 ABC-ATPase subunit interface; other site 1415167009447 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1415167009448 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1415167009449 Walker A/P-loop; other site 1415167009450 ATP binding site [chemical binding]; other site 1415167009451 Q-loop/lid; other site 1415167009452 ABC transporter signature motif; other site 1415167009453 Walker B; other site 1415167009454 D-loop; other site 1415167009455 H-loop/switch region; other site 1415167009456 NIL domain; Region: NIL; pfam09383 1415167009457 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1415167009458 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1415167009459 catalytic residues [active] 1415167009460 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1415167009461 putative active site [active] 1415167009462 putative metal binding site [ion binding]; other site 1415167009463 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1415167009464 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1415167009465 lipoyl attachment site [posttranslational modification]; other site 1415167009466 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1415167009467 ArsC family; Region: ArsC; pfam03960 1415167009468 putative ArsC-like catalytic residues; other site 1415167009469 putative TRX-like catalytic residues [active] 1415167009470 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1415167009471 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1415167009472 active site 1415167009473 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1415167009474 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1415167009475 dimer interface [polypeptide binding]; other site 1415167009476 active site 1415167009477 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1415167009478 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1415167009479 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1415167009480 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1415167009481 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1415167009482 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1415167009483 substrate binding site [chemical binding]; other site 1415167009484 oxyanion hole (OAH) forming residues; other site 1415167009485 trimer interface [polypeptide binding]; other site 1415167009486 Proline dehydrogenase; Region: Pro_dh; pfam01619 1415167009487 Coat F domain; Region: Coat_F; pfam07875 1415167009488 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167009489 MarR family; Region: MarR; pfam01047 1415167009490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167009491 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167009492 putative substrate translocation pore; other site 1415167009493 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167009494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167009495 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1415167009496 dimerization interface [polypeptide binding]; other site 1415167009497 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1415167009498 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1415167009499 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1415167009500 Walker A/P-loop; other site 1415167009501 ATP binding site [chemical binding]; other site 1415167009502 Q-loop/lid; other site 1415167009503 ABC transporter signature motif; other site 1415167009504 Walker B; other site 1415167009505 D-loop; other site 1415167009506 H-loop/switch region; other site 1415167009507 YusW-like protein; Region: YusW; pfam14039 1415167009508 short chain dehydrogenase; Provisional; Region: PRK06914 1415167009509 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1415167009510 NADP binding site [chemical binding]; other site 1415167009511 active site 1415167009512 steroid binding site; other site 1415167009513 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1415167009514 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1415167009515 dimerization interface [polypeptide binding]; other site 1415167009516 DPS ferroxidase diiron center [ion binding]; other site 1415167009517 ion pore; other site 1415167009518 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1415167009519 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1415167009520 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1415167009521 protein binding site [polypeptide binding]; other site 1415167009522 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1415167009523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167009524 active site 1415167009525 phosphorylation site [posttranslational modification] 1415167009526 intermolecular recognition site; other site 1415167009527 dimerization interface [polypeptide binding]; other site 1415167009528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1415167009529 DNA binding site [nucleotide binding] 1415167009530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1415167009531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167009532 dimerization interface [polypeptide binding]; other site 1415167009533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167009534 dimer interface [polypeptide binding]; other site 1415167009535 phosphorylation site [posttranslational modification] 1415167009536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167009537 ATP binding site [chemical binding]; other site 1415167009538 Mg2+ binding site [ion binding]; other site 1415167009539 G-X-G motif; other site 1415167009540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167009541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167009542 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1415167009543 Class II fumarases; Region: Fumarase_classII; cd01362 1415167009544 active site 1415167009545 tetramer interface [polypeptide binding]; other site 1415167009546 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1415167009547 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1415167009548 Spore germination protein; Region: Spore_permease; pfam03845 1415167009549 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1415167009550 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1415167009551 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1415167009552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167009553 active site 1415167009554 phosphorylation site [posttranslational modification] 1415167009555 intermolecular recognition site; other site 1415167009556 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1415167009557 DNA binding residues [nucleotide binding] 1415167009558 dimerization interface [polypeptide binding]; other site 1415167009559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1415167009560 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167009561 dimerization interface [polypeptide binding]; other site 1415167009562 Histidine kinase; Region: HisKA_3; pfam07730 1415167009563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167009564 ATP binding site [chemical binding]; other site 1415167009565 Mg2+ binding site [ion binding]; other site 1415167009566 G-X-G motif; other site 1415167009567 Predicted membrane protein [Function unknown]; Region: COG4758 1415167009568 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1415167009569 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1415167009570 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1415167009571 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1415167009572 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1415167009573 PspA/IM30 family; Region: PspA_IM30; pfam04012 1415167009574 H+ Antiporter protein; Region: 2A0121; TIGR00900 1415167009575 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 1415167009576 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1415167009577 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1415167009578 Walker A/P-loop; other site 1415167009579 ATP binding site [chemical binding]; other site 1415167009580 Q-loop/lid; other site 1415167009581 ABC transporter signature motif; other site 1415167009582 Walker B; other site 1415167009583 D-loop; other site 1415167009584 H-loop/switch region; other site 1415167009585 Adenosylcobinamide amidohydrolase [Coenzyme metabolism]; Region: cbiZ; COG1865 1415167009586 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1415167009587 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167009588 ABC-ATPase subunit interface; other site 1415167009589 dimer interface [polypeptide binding]; other site 1415167009590 putative PBP binding regions; other site 1415167009591 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1415167009592 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1415167009593 putative binding site residues; other site 1415167009594 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1415167009595 classical (c) SDRs; Region: SDR_c; cd05233 1415167009596 NAD(P) binding site [chemical binding]; other site 1415167009597 active site 1415167009598 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1415167009599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1415167009600 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167009601 dimer interface [polypeptide binding]; other site 1415167009602 phosphorylation site [posttranslational modification] 1415167009603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167009604 ATP binding site [chemical binding]; other site 1415167009605 Mg2+ binding site [ion binding]; other site 1415167009606 G-X-G motif; other site 1415167009607 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1415167009608 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167009609 DNA binding residues [nucleotide binding] 1415167009610 YvrJ protein family; Region: YvrJ; pfam12841 1415167009611 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1415167009612 Cupin; Region: Cupin_1; smart00835 1415167009613 Cupin; Region: Cupin_1; smart00835 1415167009614 Regulatory protein YrvL; Region: YrvL; pfam14184 1415167009615 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1415167009616 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1415167009617 FtsX-like permease family; Region: FtsX; pfam02687 1415167009618 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1415167009619 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1415167009620 Walker A/P-loop; other site 1415167009621 ATP binding site [chemical binding]; other site 1415167009622 Q-loop/lid; other site 1415167009623 ABC transporter signature motif; other site 1415167009624 Walker B; other site 1415167009625 D-loop; other site 1415167009626 H-loop/switch region; other site 1415167009627 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1415167009628 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1415167009629 DNA damage checkpoint protein; Region: LCD1; pfam09798 1415167009630 HlyD family secretion protein; Region: HlyD_3; pfam13437 1415167009631 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1415167009632 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1415167009633 Walker A/P-loop; other site 1415167009634 ATP binding site [chemical binding]; other site 1415167009635 Q-loop/lid; other site 1415167009636 ABC transporter signature motif; other site 1415167009637 Walker B; other site 1415167009638 D-loop; other site 1415167009639 H-loop/switch region; other site 1415167009640 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1415167009641 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167009642 ABC-ATPase subunit interface; other site 1415167009643 dimer interface [polypeptide binding]; other site 1415167009644 putative PBP binding regions; other site 1415167009645 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1415167009646 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1415167009647 ABC-ATPase subunit interface; other site 1415167009648 dimer interface [polypeptide binding]; other site 1415167009649 putative PBP binding regions; other site 1415167009650 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1415167009651 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1415167009652 putative ligand binding residues [chemical binding]; other site 1415167009653 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1415167009654 small, acid-soluble spore protein, SspJ family; Region: spore_sspJ; TIGR02863 1415167009655 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1415167009656 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1415167009657 Sulfatase; Region: Sulfatase; pfam00884 1415167009658 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1415167009659 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1415167009660 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1415167009661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167009662 dimer interface [polypeptide binding]; other site 1415167009663 conserved gate region; other site 1415167009664 putative PBP binding loops; other site 1415167009665 ABC-ATPase subunit interface; other site 1415167009666 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1415167009667 sulfite reductase subunit beta; Provisional; Region: PRK13504 1415167009668 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1415167009669 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1415167009670 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1415167009671 Flavodoxin; Region: Flavodoxin_1; pfam00258 1415167009672 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1415167009673 FAD binding pocket [chemical binding]; other site 1415167009674 FAD binding motif [chemical binding]; other site 1415167009675 catalytic residues [active] 1415167009676 NAD binding pocket [chemical binding]; other site 1415167009677 phosphate binding motif [ion binding]; other site 1415167009678 beta-alpha-beta structure motif; other site 1415167009679 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1415167009680 Part of AAA domain; Region: AAA_19; pfam13245 1415167009681 Family description; Region: UvrD_C_2; pfam13538 1415167009682 Predicted membrane protein [Function unknown]; Region: COG2860 1415167009683 UPF0126 domain; Region: UPF0126; pfam03458 1415167009684 UPF0126 domain; Region: UPF0126; pfam03458 1415167009685 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1415167009686 Thioredoxin; Region: Thioredoxin_4; pfam13462 1415167009687 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1415167009688 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1415167009689 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1415167009690 metal-binding site [ion binding] 1415167009691 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1415167009692 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1415167009693 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1415167009694 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1415167009695 metal-binding site [ion binding] 1415167009696 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1415167009697 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1415167009698 metal-binding site [ion binding] 1415167009699 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1415167009700 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1415167009701 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1415167009702 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1415167009703 metal-binding site [ion binding] 1415167009704 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 1415167009705 putative homodimer interface [polypeptide binding]; other site 1415167009706 putative homotetramer interface [polypeptide binding]; other site 1415167009707 allosteric switch controlling residues; other site 1415167009708 putative metal binding site [ion binding]; other site 1415167009709 putative homodimer-homodimer interface [polypeptide binding]; other site 1415167009710 putative oxidoreductase; Provisional; Region: PRK11579 1415167009711 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1415167009712 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1415167009713 azoreductase; Reviewed; Region: PRK00170 1415167009714 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1415167009715 Predicted membrane protein [Function unknown]; Region: COG1289 1415167009716 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1415167009717 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1415167009718 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1415167009719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167009720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167009721 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1415167009722 classical (c) SDRs; Region: SDR_c; cd05233 1415167009723 NAD(P) binding site [chemical binding]; other site 1415167009724 active site 1415167009725 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1415167009726 SmpB-tmRNA interface; other site 1415167009727 ribonuclease R; Region: RNase_R; TIGR02063 1415167009728 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1415167009729 Cold shock protein domain; Region: CSP; smart00357 1415167009730 RNB domain; Region: RNB; pfam00773 1415167009731 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1415167009732 RNA binding site [nucleotide binding]; other site 1415167009733 Esterase/lipase [General function prediction only]; Region: COG1647 1415167009734 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1415167009735 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1415167009736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167009737 sequence-specific DNA binding site [nucleotide binding]; other site 1415167009738 salt bridge; other site 1415167009739 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1415167009740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167009741 non-specific DNA binding site [nucleotide binding]; other site 1415167009742 salt bridge; other site 1415167009743 sequence-specific DNA binding site [nucleotide binding]; other site 1415167009744 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1415167009745 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167009746 dimerization interface [polypeptide binding]; other site 1415167009747 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1415167009748 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1415167009749 dimer interface [polypeptide binding]; other site 1415167009750 putative CheW interface [polypeptide binding]; other site 1415167009751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167009752 dimer interface [polypeptide binding]; other site 1415167009753 conserved gate region; other site 1415167009754 putative PBP binding loops; other site 1415167009755 ABC-ATPase subunit interface; other site 1415167009756 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1415167009757 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1415167009758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167009759 dimer interface [polypeptide binding]; other site 1415167009760 conserved gate region; other site 1415167009761 putative PBP binding loops; other site 1415167009762 ABC-ATPase subunit interface; other site 1415167009763 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1415167009764 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1415167009765 Walker A/P-loop; other site 1415167009766 ATP binding site [chemical binding]; other site 1415167009767 Q-loop/lid; other site 1415167009768 ABC transporter signature motif; other site 1415167009769 Walker B; other site 1415167009770 D-loop; other site 1415167009771 H-loop/switch region; other site 1415167009772 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1415167009773 Predicted transcriptional regulators [Transcription]; Region: COG1510 1415167009774 MarR family; Region: MarR_2; pfam12802 1415167009775 antimicrobial peptide system protein, SdpB family; Region: export_SdpB; TIGR04033 1415167009776 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1415167009777 Predicted integral membrane protein [Function unknown]; Region: COG5658 1415167009778 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1415167009779 SdpI/YhfL protein family; Region: SdpI; pfam13630 1415167009780 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167009781 dimerization interface [polypeptide binding]; other site 1415167009782 putative DNA binding site [nucleotide binding]; other site 1415167009783 putative Zn2+ binding site [ion binding]; other site 1415167009784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167009785 dimer interface [polypeptide binding]; other site 1415167009786 conserved gate region; other site 1415167009787 putative PBP binding loops; other site 1415167009788 ABC-ATPase subunit interface; other site 1415167009789 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1415167009790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167009791 dimer interface [polypeptide binding]; other site 1415167009792 conserved gate region; other site 1415167009793 putative PBP binding loops; other site 1415167009794 ABC-ATPase subunit interface; other site 1415167009795 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1415167009796 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1415167009797 Walker A/P-loop; other site 1415167009798 ATP binding site [chemical binding]; other site 1415167009799 Q-loop/lid; other site 1415167009800 ABC transporter signature motif; other site 1415167009801 Walker B; other site 1415167009802 D-loop; other site 1415167009803 H-loop/switch region; other site 1415167009804 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1415167009805 Predicted transcriptional regulators [Transcription]; Region: COG1510 1415167009806 MarR family; Region: MarR_2; pfam12802 1415167009807 membrane protein, MarC family; Region: TIGR00427 1415167009808 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1415167009809 pentamer interface [polypeptide binding]; other site 1415167009810 dodecaamer interface [polypeptide binding]; other site 1415167009811 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1415167009812 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1415167009813 Double zinc ribbon; Region: DZR; pfam12773 1415167009814 Predicted membrane protein [Function unknown]; Region: COG4640 1415167009815 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1415167009816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167009817 Coenzyme A binding pocket [chemical binding]; other site 1415167009818 enolase; Provisional; Region: eno; PRK00077 1415167009819 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1415167009820 dimer interface [polypeptide binding]; other site 1415167009821 metal binding site [ion binding]; metal-binding site 1415167009822 substrate binding pocket [chemical binding]; other site 1415167009823 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1415167009824 phosphoglyceromutase; Provisional; Region: PRK05434 1415167009825 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1415167009826 triosephosphate isomerase; Provisional; Region: PRK14565 1415167009827 substrate binding site [chemical binding]; other site 1415167009828 dimer interface [polypeptide binding]; other site 1415167009829 catalytic triad [active] 1415167009830 Phosphoglycerate kinase; Region: PGK; pfam00162 1415167009831 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1415167009832 substrate binding site [chemical binding]; other site 1415167009833 hinge regions; other site 1415167009834 ADP binding site [chemical binding]; other site 1415167009835 catalytic site [active] 1415167009836 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1415167009837 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1415167009838 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1415167009839 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1415167009840 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1415167009841 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1415167009842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167009843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167009844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167009845 DNA-binding site [nucleotide binding]; DNA binding site 1415167009846 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1415167009847 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1415167009848 putative dimerization interface [polypeptide binding]; other site 1415167009849 putative ligand binding site [chemical binding]; other site 1415167009850 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1415167009851 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1415167009852 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1415167009853 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167009854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167009855 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1415167009856 dimerization interface [polypeptide binding]; other site 1415167009857 EamA-like transporter family; Region: EamA; pfam00892 1415167009858 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1415167009859 EamA-like transporter family; Region: EamA; pfam00892 1415167009860 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1415167009861 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1415167009862 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1415167009863 active site 1415167009864 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1415167009865 iron-sulfur cluster-binding protein; Region: TIGR00273 1415167009866 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1415167009867 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1415167009868 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1415167009869 Cysteine-rich domain; Region: CCG; pfam02754 1415167009870 Cysteine-rich domain; Region: CCG; pfam02754 1415167009871 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1415167009872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167009873 active site 1415167009874 phosphorylation site [posttranslational modification] 1415167009875 intermolecular recognition site; other site 1415167009876 dimerization interface [polypeptide binding]; other site 1415167009877 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1415167009878 DNA binding residues [nucleotide binding] 1415167009879 dimerization interface [polypeptide binding]; other site 1415167009880 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1415167009881 Histidine kinase; Region: HisKA_3; pfam07730 1415167009882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167009883 ATP binding site [chemical binding]; other site 1415167009884 Mg2+ binding site [ion binding]; other site 1415167009885 G-X-G motif; other site 1415167009886 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1415167009887 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1415167009888 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1415167009889 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1415167009890 Walker A/P-loop; other site 1415167009891 ATP binding site [chemical binding]; other site 1415167009892 Q-loop/lid; other site 1415167009893 ABC transporter signature motif; other site 1415167009894 Walker B; other site 1415167009895 D-loop; other site 1415167009896 H-loop/switch region; other site 1415167009897 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1415167009898 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1415167009899 catalytic site [active] 1415167009900 PAS domain S-box; Region: sensory_box; TIGR00229 1415167009901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167009902 putative active site [active] 1415167009903 heme pocket [chemical binding]; other site 1415167009904 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1415167009905 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1415167009906 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1415167009907 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1415167009908 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1415167009909 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1415167009910 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1415167009911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167009912 dimer interface [polypeptide binding]; other site 1415167009913 conserved gate region; other site 1415167009914 putative PBP binding loops; other site 1415167009915 ABC-ATPase subunit interface; other site 1415167009916 TM2 domain; Region: TM2; pfam05154 1415167009917 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1415167009918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167009919 dimer interface [polypeptide binding]; other site 1415167009920 conserved gate region; other site 1415167009921 ABC-ATPase subunit interface; other site 1415167009922 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1415167009923 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1415167009924 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1415167009925 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1415167009926 DNA binding site [nucleotide binding] 1415167009927 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1415167009928 putative dimerization interface [polypeptide binding]; other site 1415167009929 putative ligand binding site [chemical binding]; other site 1415167009930 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1415167009931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167009932 DNA-binding site [nucleotide binding]; DNA binding site 1415167009933 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1415167009934 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1415167009935 L-lactate permease; Region: Lactate_perm; pfam02652 1415167009936 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1415167009937 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1415167009938 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1415167009939 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1415167009940 YvfG protein; Region: YvfG; pfam09628 1415167009941 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1415167009942 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1415167009943 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1415167009944 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1415167009945 inhibitor-cofactor binding pocket; inhibition site 1415167009946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167009947 catalytic residue [active] 1415167009948 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1415167009949 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1415167009950 putative trimer interface [polypeptide binding]; other site 1415167009951 putative CoA binding site [chemical binding]; other site 1415167009952 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1415167009953 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1415167009954 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1415167009955 active site 1415167009956 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1415167009957 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1415167009958 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1415167009959 active site 1415167009960 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1415167009961 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1415167009962 putative ADP-binding pocket [chemical binding]; other site 1415167009963 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1415167009964 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1415167009965 active site 1415167009966 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1415167009967 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1415167009968 putative ADP-binding pocket [chemical binding]; other site 1415167009969 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1415167009970 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1415167009971 NAD(P) binding site [chemical binding]; other site 1415167009972 homodimer interface [polypeptide binding]; other site 1415167009973 substrate binding site [chemical binding]; other site 1415167009974 active site 1415167009975 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1415167009976 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1415167009977 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1415167009978 Chain length determinant protein; Region: Wzz; cl15801 1415167009979 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1415167009980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1415167009981 non-specific DNA binding site [nucleotide binding]; other site 1415167009982 salt bridge; other site 1415167009983 sequence-specific DNA binding site [nucleotide binding]; other site 1415167009984 Anti-repressor SinI; Region: SinI; pfam08671 1415167009985 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1415167009986 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1415167009987 substrate binding pocket [chemical binding]; other site 1415167009988 catalytic triad [active] 1415167009989 Phenolic acid decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3479 1415167009990 premature stop codon at amino acid position 41 1415167009991 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1415167009992 aspartate racemase; Region: asp_race; TIGR00035 1415167009993 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1415167009994 Beta-lactamase; Region: Beta-lactamase; pfam00144 1415167009995 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1415167009996 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1415167009997 active site 1415167009998 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1415167009999 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1415167010000 substrate binding [chemical binding]; other site 1415167010001 active site 1415167010002 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1415167010003 amino acid transporter; Region: 2A0306; TIGR00909 1415167010004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167010005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167010006 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1415167010007 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1415167010008 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1415167010009 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1415167010010 FAD binding domain; Region: FAD_binding_4; pfam01565 1415167010011 Berberine and berberine like; Region: BBE; pfam08031 1415167010012 Patatin [General function prediction only]; Region: COG3621 1415167010013 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 1415167010014 active site 1415167010015 nucleophile elbow; other site 1415167010016 Clp protease; Region: CLP_protease; pfam00574 1415167010017 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1415167010018 oligomer interface [polypeptide binding]; other site 1415167010019 active site residues [active] 1415167010020 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1415167010021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167010022 motif II; other site 1415167010023 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1415167010024 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1415167010025 Ca binding site [ion binding]; other site 1415167010026 active site 1415167010027 catalytic site [active] 1415167010028 maltose phosphorylase; Provisional; Region: PRK13807 1415167010029 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1415167010030 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1415167010031 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1415167010032 Predicted integral membrane protein [Function unknown]; Region: COG5521 1415167010033 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1415167010034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167010035 dimer interface [polypeptide binding]; other site 1415167010036 conserved gate region; other site 1415167010037 ABC-ATPase subunit interface; other site 1415167010038 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1415167010039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167010040 dimer interface [polypeptide binding]; other site 1415167010041 conserved gate region; other site 1415167010042 putative PBP binding loops; other site 1415167010043 ABC-ATPase subunit interface; other site 1415167010044 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1415167010045 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1415167010046 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1415167010047 homodimer interface [polypeptide binding]; other site 1415167010048 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1415167010049 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1415167010050 active site 1415167010051 homodimer interface [polypeptide binding]; other site 1415167010052 catalytic site [active] 1415167010053 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1415167010054 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1415167010055 DNA binding site [nucleotide binding] 1415167010056 domain linker motif; other site 1415167010057 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1415167010058 ligand binding site [chemical binding]; other site 1415167010059 dimerization interface [polypeptide binding]; other site 1415167010060 TIGR00730 family protein; Region: TIGR00730 1415167010061 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1415167010062 metal binding site [ion binding]; metal-binding site 1415167010063 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1415167010064 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1415167010065 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1415167010066 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1415167010067 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1415167010068 active site clefts [active] 1415167010069 zinc binding site [ion binding]; other site 1415167010070 dimer interface [polypeptide binding]; other site 1415167010071 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1415167010072 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1415167010073 dimerization interface [polypeptide binding]; other site 1415167010074 ligand binding site [chemical binding]; other site 1415167010075 NADP binding site [chemical binding]; other site 1415167010076 catalytic site [active] 1415167010077 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1415167010078 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1415167010079 Walker A/P-loop; other site 1415167010080 ATP binding site [chemical binding]; other site 1415167010081 Q-loop/lid; other site 1415167010082 ABC transporter signature motif; other site 1415167010083 Walker B; other site 1415167010084 D-loop; other site 1415167010085 H-loop/switch region; other site 1415167010086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1415167010087 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1415167010088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167010089 ATP binding site [chemical binding]; other site 1415167010090 Mg2+ binding site [ion binding]; other site 1415167010091 G-X-G motif; other site 1415167010092 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1415167010093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167010094 active site 1415167010095 phosphorylation site [posttranslational modification] 1415167010096 intermolecular recognition site; other site 1415167010097 dimerization interface [polypeptide binding]; other site 1415167010098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1415167010099 DNA binding site [nucleotide binding] 1415167010100 Lysis protein; Region: Lysis_col; pfam02402 1415167010101 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1415167010102 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1415167010103 dimerization domain swap beta strand [polypeptide binding]; other site 1415167010104 regulatory protein interface [polypeptide binding]; other site 1415167010105 active site 1415167010106 regulatory phosphorylation site [posttranslational modification]; other site 1415167010107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1415167010108 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1415167010109 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1415167010110 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1415167010111 phosphate binding site [ion binding]; other site 1415167010112 putative substrate binding pocket [chemical binding]; other site 1415167010113 dimer interface [polypeptide binding]; other site 1415167010114 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1415167010115 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1415167010116 putative active site [active] 1415167010117 nucleotide binding site [chemical binding]; other site 1415167010118 nudix motif; other site 1415167010119 putative metal binding site [ion binding]; other site 1415167010120 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1415167010121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1415167010122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1415167010123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1415167010124 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1415167010125 NlpC/P60 family; Region: NLPC_P60; pfam00877 1415167010126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167010127 binding surface 1415167010128 TPR motif; other site 1415167010129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167010130 TPR motif; other site 1415167010131 binding surface 1415167010132 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1415167010133 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1415167010134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1415167010135 Walker A/P-loop; other site 1415167010136 ATP binding site [chemical binding]; other site 1415167010137 Q-loop/lid; other site 1415167010138 ABC transporter signature motif; other site 1415167010139 Walker B; other site 1415167010140 D-loop; other site 1415167010141 H-loop/switch region; other site 1415167010142 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1415167010143 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1415167010144 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1415167010145 metal binding site [ion binding]; metal-binding site 1415167010146 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1415167010147 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1415167010148 substrate binding site [chemical binding]; other site 1415167010149 glutamase interaction surface [polypeptide binding]; other site 1415167010150 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1415167010151 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1415167010152 catalytic residues [active] 1415167010153 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1415167010154 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1415167010155 putative active site [active] 1415167010156 oxyanion strand; other site 1415167010157 catalytic triad [active] 1415167010158 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1415167010159 putative active site pocket [active] 1415167010160 4-fold oligomerization interface [polypeptide binding]; other site 1415167010161 metal binding residues [ion binding]; metal-binding site 1415167010162 3-fold/trimer interface [polypeptide binding]; other site 1415167010163 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1415167010164 histidinol dehydrogenase; Region: hisD; TIGR00069 1415167010165 NAD binding site [chemical binding]; other site 1415167010166 dimerization interface [polypeptide binding]; other site 1415167010167 product binding site; other site 1415167010168 substrate binding site [chemical binding]; other site 1415167010169 zinc binding site [ion binding]; other site 1415167010170 catalytic residues [active] 1415167010171 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1415167010172 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1415167010173 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1415167010174 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1415167010175 dimer interface [polypeptide binding]; other site 1415167010176 motif 1; other site 1415167010177 active site 1415167010178 motif 2; other site 1415167010179 motif 3; other site 1415167010180 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1415167010181 putative active site [active] 1415167010182 Pectate lyase; Region: Pectate_lyase; pfam03211 1415167010183 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1415167010184 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1415167010185 CoA binding site [chemical binding]; other site 1415167010186 active site 1415167010187 pyrophosphatase PpaX; Provisional; Region: PRK13288 1415167010188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167010189 motif II; other site 1415167010190 Nucleoside recognition; Region: Gate; pfam07670 1415167010191 Nucleoside recognition; Region: Gate; pfam07670 1415167010192 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1415167010193 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1415167010194 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1415167010195 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1415167010196 Hpr binding site; other site 1415167010197 active site 1415167010198 homohexamer subunit interaction site [polypeptide binding]; other site 1415167010199 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1415167010200 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1415167010201 active site 1415167010202 dimer interface [polypeptide binding]; other site 1415167010203 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1415167010204 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1415167010205 active site 1415167010206 trimer interface [polypeptide binding]; other site 1415167010207 allosteric site; other site 1415167010208 active site lid [active] 1415167010209 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1415167010210 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1415167010211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167010212 DNA-binding site [nucleotide binding]; DNA binding site 1415167010213 UTRA domain; Region: UTRA; pfam07702 1415167010214 Lamin Tail Domain; Region: LTD; pfam00932 1415167010215 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1415167010216 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1415167010217 putative active site [active] 1415167010218 putative metal binding site [ion binding]; other site 1415167010219 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167010220 MarR family; Region: MarR; pfam01047 1415167010221 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1415167010222 Cytochrome P450; Region: p450; cl12078 1415167010223 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167010224 MarR family; Region: MarR; pfam01047 1415167010225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167010226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167010227 putative substrate translocation pore; other site 1415167010228 Predicted membrane protein [Function unknown]; Region: COG1950 1415167010229 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1415167010230 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1415167010231 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1415167010232 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1415167010233 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1415167010234 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1415167010235 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1415167010236 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1415167010237 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1415167010238 excinuclease ABC subunit B; Provisional; Region: PRK05298 1415167010239 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1415167010240 ATP binding site [chemical binding]; other site 1415167010241 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167010242 nucleotide binding region [chemical binding]; other site 1415167010243 ATP-binding site [chemical binding]; other site 1415167010244 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1415167010245 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1415167010246 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1415167010247 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 1415167010248 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1415167010249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167010250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167010251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167010252 putative substrate translocation pore; other site 1415167010253 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1415167010254 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1415167010255 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1415167010256 C-terminal peptidase (prc); Region: prc; TIGR00225 1415167010257 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1415167010258 protein binding site [polypeptide binding]; other site 1415167010259 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1415167010260 Catalytic dyad [active] 1415167010261 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1415167010262 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1415167010263 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1415167010264 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1415167010265 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 1415167010266 Walker A/P-loop; other site 1415167010267 ATP binding site [chemical binding]; other site 1415167010268 Q-loop/lid; other site 1415167010269 ABC transporter signature motif; other site 1415167010270 Walker B; other site 1415167010271 D-loop; other site 1415167010272 H-loop/switch region; other site 1415167010273 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1415167010274 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1415167010275 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1415167010276 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167010277 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167010278 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1415167010279 peptide chain release factor 2; Provisional; Region: PRK06746 1415167010280 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1415167010281 RF-1 domain; Region: RF-1; pfam00472 1415167010282 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1415167010283 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1415167010284 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1415167010285 nucleotide binding region [chemical binding]; other site 1415167010286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1415167010287 ATP-binding site [chemical binding]; other site 1415167010288 SEC-C motif; Region: SEC-C; pfam02810 1415167010289 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1415167010290 30S subunit binding site; other site 1415167010291 Flagellar protein FliT; Region: FliT; pfam05400 1415167010292 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 1415167010293 flagellar capping protein; Validated; Region: fliD; PRK07737 1415167010294 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1415167010295 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1415167010296 FlaG protein; Region: FlaG; cl00591 1415167010297 flagellin; Provisional; Region: PRK12804 1415167010298 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1415167010299 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1415167010300 carbon storage regulator; Provisional; Region: PRK01712 1415167010301 flagellar assembly protein FliW; Provisional; Region: PRK13285 1415167010302 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1415167010303 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1415167010304 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1415167010305 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1415167010306 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1415167010307 FlgN protein; Region: FlgN; pfam05130 1415167010308 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 1415167010309 flagellar operon protein TIGR03826; Region: YvyF 1415167010310 comF family protein; Region: comF; TIGR00201 1415167010311 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1415167010312 active site 1415167010313 Late competence development protein ComFB; Region: ComFB; pfam10719 1415167010314 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1415167010315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1415167010316 ATP binding site [chemical binding]; other site 1415167010317 putative Mg++ binding site [ion binding]; other site 1415167010318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167010319 nucleotide binding region [chemical binding]; other site 1415167010320 ATP-binding site [chemical binding]; other site 1415167010321 EDD domain protein, DegV family; Region: DegV; TIGR00762 1415167010322 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1415167010323 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1415167010324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167010325 active site 1415167010326 phosphorylation site [posttranslational modification] 1415167010327 intermolecular recognition site; other site 1415167010328 dimerization interface [polypeptide binding]; other site 1415167010329 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1415167010330 DNA binding residues [nucleotide binding] 1415167010331 dimerization interface [polypeptide binding]; other site 1415167010332 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1415167010333 Histidine kinase; Region: HisKA_3; pfam07730 1415167010334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167010335 ATP binding site [chemical binding]; other site 1415167010336 Mg2+ binding site [ion binding]; other site 1415167010337 G-X-G motif; other site 1415167010338 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1415167010339 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1415167010340 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1415167010341 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1415167010342 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1415167010343 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1415167010344 Mg++ binding site [ion binding]; other site 1415167010345 putative catalytic motif [active] 1415167010346 substrate binding site [chemical binding]; other site 1415167010347 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1415167010348 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1415167010349 putative homodimer interface [polypeptide binding]; other site 1415167010350 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1415167010351 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1415167010352 active site 1415167010353 Chain length determinant protein; Region: Wzz; pfam02706 1415167010354 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1415167010355 O-Antigen ligase; Region: Wzy_C; pfam04932 1415167010356 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1415167010357 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1415167010358 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1415167010359 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1415167010360 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1415167010361 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1415167010362 colanic acid exporter; Provisional; Region: PRK10459 1415167010363 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1415167010364 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1415167010365 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1415167010366 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1415167010367 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1415167010368 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1415167010369 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1415167010370 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1415167010371 active site 1415167010372 metal binding site [ion binding]; metal-binding site 1415167010373 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1415167010374 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1415167010375 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1415167010376 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1415167010377 Stage II sporulation protein; Region: SpoIID; pfam08486 1415167010378 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1415167010379 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 1415167010380 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1415167010381 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1415167010382 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1415167010383 active site 1415167010384 homodimer interface [polypeptide binding]; other site 1415167010385 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1415167010386 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1415167010387 active site 1415167010388 tetramer interface; other site 1415167010389 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1415167010390 active site 1415167010391 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1415167010392 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1415167010393 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1415167010394 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1415167010395 active site 1415167010396 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1415167010397 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1415167010398 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1415167010399 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1415167010400 Walker A/P-loop; other site 1415167010401 ATP binding site [chemical binding]; other site 1415167010402 Q-loop/lid; other site 1415167010403 ABC transporter signature motif; other site 1415167010404 Walker B; other site 1415167010405 D-loop; other site 1415167010406 H-loop/switch region; other site 1415167010407 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1415167010408 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1415167010409 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1415167010410 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1415167010411 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1415167010412 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1415167010413 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1415167010414 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1415167010415 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1415167010416 active site 1415167010417 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1415167010418 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1415167010419 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1415167010420 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1415167010421 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1415167010422 Bacterial SH3 domain; Region: SH3_3; pfam08239 1415167010423 Lysozyme subfamily 2; Region: LYZ2; smart00047 1415167010424 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1415167010425 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1415167010426 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1415167010427 Spore germination protein; Region: Spore_permease; pfam03845 1415167010428 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1415167010429 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1415167010430 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1415167010431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167010432 putative substrate translocation pore; other site 1415167010433 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1415167010434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167010435 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1415167010436 active site 1415167010437 motif I; other site 1415167010438 motif II; other site 1415167010439 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1415167010440 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1415167010441 NlpC/P60 family; Region: NLPC_P60; pfam00877 1415167010442 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1415167010443 NlpC/P60 family; Region: NLPC_P60; pfam00877 1415167010444 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1415167010445 NlpC/P60 family; Region: NLPC_P60; pfam00877 1415167010446 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1415167010447 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1415167010448 putative active site [active] 1415167010449 putative metal binding site [ion binding]; other site 1415167010450 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1415167010451 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1415167010452 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1415167010453 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1415167010454 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1415167010455 DNA binding site [nucleotide binding] 1415167010456 domain linker motif; other site 1415167010457 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1415167010458 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1415167010459 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1415167010460 substrate binding site [chemical binding]; other site 1415167010461 dimer interface [polypeptide binding]; other site 1415167010462 ATP binding site [chemical binding]; other site 1415167010463 D-ribose pyranase; Provisional; Region: PRK11797 1415167010464 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1415167010465 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1415167010466 Walker A/P-loop; other site 1415167010467 ATP binding site [chemical binding]; other site 1415167010468 Q-loop/lid; other site 1415167010469 ABC transporter signature motif; other site 1415167010470 Walker B; other site 1415167010471 D-loop; other site 1415167010472 H-loop/switch region; other site 1415167010473 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1415167010474 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1415167010475 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1415167010476 ligand binding site [chemical binding]; other site 1415167010477 dimerization interface [polypeptide binding]; other site 1415167010478 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1415167010479 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1415167010480 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1415167010481 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1415167010482 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1415167010483 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1415167010484 acetolactate synthase; Reviewed; Region: PRK08617 1415167010485 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1415167010486 PYR/PP interface [polypeptide binding]; other site 1415167010487 dimer interface [polypeptide binding]; other site 1415167010488 TPP binding site [chemical binding]; other site 1415167010489 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1415167010490 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1415167010491 TPP-binding site [chemical binding]; other site 1415167010492 dimer interface [polypeptide binding]; other site 1415167010493 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1415167010494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167010495 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1415167010496 putative dimerization interface [polypeptide binding]; other site 1415167010497 putative substrate binding pocket [chemical binding]; other site 1415167010498 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1415167010499 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1415167010500 transmembrane helices; other site 1415167010501 CotH protein; Region: CotH; pfam08757 1415167010502 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1415167010503 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1415167010504 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1415167010505 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1415167010506 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1415167010507 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167010508 putative DNA binding site [nucleotide binding]; other site 1415167010509 putative Zn2+ binding site [ion binding]; other site 1415167010510 AsnC family; Region: AsnC_trans_reg; pfam01037 1415167010511 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1415167010512 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1415167010513 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1415167010514 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1415167010515 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167010516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167010517 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1415167010518 dimerization interface [polypeptide binding]; other site 1415167010519 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1415167010520 Active_site [active] 1415167010521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1415167010522 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1415167010523 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1415167010524 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 1415167010525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1415167010526 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1415167010527 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1415167010528 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1415167010529 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1415167010530 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1415167010531 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1415167010532 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1415167010533 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1415167010534 Chain length determinant protein; Region: Wzz; cl15801 1415167010535 SWIM zinc finger; Region: SWIM; pfam04434 1415167010536 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1415167010537 SNF2 Helicase protein; Region: DUF3670; pfam12419 1415167010538 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1415167010539 ATP binding site [chemical binding]; other site 1415167010540 putative Mg++ binding site [ion binding]; other site 1415167010541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167010542 nucleotide binding region [chemical binding]; other site 1415167010543 ATP-binding site [chemical binding]; other site 1415167010544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167010545 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1415167010546 active site 1415167010547 motif I; other site 1415167010548 motif II; other site 1415167010549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167010550 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1415167010551 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1415167010552 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1415167010553 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1415167010554 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1415167010555 dimer interface [polypeptide binding]; other site 1415167010556 ssDNA binding site [nucleotide binding]; other site 1415167010557 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1415167010558 YwpF-like protein; Region: YwpF; pfam14183 1415167010559 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1415167010560 active site 1415167010561 catalytic site [active] 1415167010562 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1415167010563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167010564 intermolecular recognition site; other site 1415167010565 active site 1415167010566 dimerization interface [polypeptide binding]; other site 1415167010567 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1415167010568 Histidine kinase; Region: His_kinase; pfam06580 1415167010569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167010570 ATP binding site [chemical binding]; other site 1415167010571 Mg2+ binding site [ion binding]; other site 1415167010572 G-X-G motif; other site 1415167010573 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1415167010574 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1415167010575 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1415167010576 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167010577 binding surface 1415167010578 TPR motif; other site 1415167010579 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1415167010580 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1415167010581 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1415167010582 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1415167010583 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1415167010584 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1415167010585 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1415167010586 MreB and similar proteins; Region: MreB_like; cd10225 1415167010587 nucleotide binding site [chemical binding]; other site 1415167010588 Mg binding site [ion binding]; other site 1415167010589 putative protofilament interaction site [polypeptide binding]; other site 1415167010590 RodZ interaction site [polypeptide binding]; other site 1415167010591 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1415167010592 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167010593 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167010594 putative Zn2+ binding site [ion binding]; other site 1415167010595 putative DNA binding site [nucleotide binding]; other site 1415167010596 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167010597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167010598 putative substrate translocation pore; other site 1415167010599 Right handed beta helix region; Region: Beta_helix; pfam13229 1415167010600 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1415167010601 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1415167010602 Na binding site [ion binding]; other site 1415167010603 putative substrate binding site [chemical binding]; other site 1415167010604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167010605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167010606 putative substrate translocation pore; other site 1415167010607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167010608 Isochorismatase family; Region: Isochorismatase; pfam00857 1415167010609 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1415167010610 catalytic triad [active] 1415167010611 conserved cis-peptide bond; other site 1415167010612 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1415167010613 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1415167010614 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1415167010615 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1415167010616 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1415167010617 active site 1415167010618 VanZ like family; Region: VanZ; pfam04892 1415167010619 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1415167010620 Peptidase family M23; Region: Peptidase_M23; pfam01551 1415167010621 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1415167010622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167010623 Coenzyme A binding pocket [chemical binding]; other site 1415167010624 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1415167010625 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1415167010626 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1415167010627 putative active site [active] 1415167010628 catalytic site [active] 1415167010629 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1415167010630 putative active site [active] 1415167010631 catalytic site [active] 1415167010632 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1415167010633 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1415167010634 DNA binding residues [nucleotide binding] 1415167010635 dimer interface [polypeptide binding]; other site 1415167010636 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1415167010637 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1415167010638 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1415167010639 NAD binding site [chemical binding]; other site 1415167010640 substrate binding site [chemical binding]; other site 1415167010641 putative active site [active] 1415167010642 Predicted transcriptional regulator [Transcription]; Region: COG1959 1415167010643 Transcriptional regulator; Region: Rrf2; pfam02082 1415167010644 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1415167010645 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1415167010646 subunit interactions [polypeptide binding]; other site 1415167010647 active site 1415167010648 flap region; other site 1415167010649 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1415167010650 gamma-beta subunit interface [polypeptide binding]; other site 1415167010651 alpha-beta subunit interface [polypeptide binding]; other site 1415167010652 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1415167010653 alpha-gamma subunit interface [polypeptide binding]; other site 1415167010654 beta-gamma subunit interface [polypeptide binding]; other site 1415167010655 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1415167010656 CsbD-like; Region: CsbD; pfam05532 1415167010657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167010658 binding surface 1415167010659 TPR motif; other site 1415167010660 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1415167010661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167010662 binding surface 1415167010663 TPR motif; other site 1415167010664 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1415167010665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167010666 FeS/SAM binding site; other site 1415167010667 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1415167010668 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1415167010669 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1415167010670 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1415167010671 metal ion-dependent adhesion site (MIDAS); other site 1415167010672 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1415167010673 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1415167010674 hinge; other site 1415167010675 active site 1415167010676 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1415167010677 Predicted membrane protein [Function unknown]; Region: COG4836 1415167010678 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1415167010679 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1415167010680 gamma subunit interface [polypeptide binding]; other site 1415167010681 epsilon subunit interface [polypeptide binding]; other site 1415167010682 LBP interface [polypeptide binding]; other site 1415167010683 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1415167010684 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1415167010685 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1415167010686 alpha subunit interaction interface [polypeptide binding]; other site 1415167010687 Walker A motif; other site 1415167010688 ATP binding site [chemical binding]; other site 1415167010689 Walker B motif; other site 1415167010690 inhibitor binding site; inhibition site 1415167010691 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1415167010692 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1415167010693 core domain interface [polypeptide binding]; other site 1415167010694 delta subunit interface [polypeptide binding]; other site 1415167010695 epsilon subunit interface [polypeptide binding]; other site 1415167010696 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1415167010697 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1415167010698 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1415167010699 beta subunit interaction interface [polypeptide binding]; other site 1415167010700 Walker A motif; other site 1415167010701 ATP binding site [chemical binding]; other site 1415167010702 Walker B motif; other site 1415167010703 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1415167010704 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1415167010705 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1415167010706 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1415167010707 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1415167010708 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1415167010709 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1415167010710 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1415167010711 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1415167010712 active site 1415167010713 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1415167010714 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1415167010715 dimer interface [polypeptide binding]; other site 1415167010716 active site 1415167010717 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1415167010718 folate binding site [chemical binding]; other site 1415167010719 hypothetical protein; Provisional; Region: PRK13690 1415167010720 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1415167010721 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1415167010722 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1415167010723 active site 1415167010724 Predicted membrane protein [Function unknown]; Region: COG1971 1415167010725 Domain of unknown function DUF; Region: DUF204; pfam02659 1415167010726 Domain of unknown function DUF; Region: DUF204; pfam02659 1415167010727 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1415167010728 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1415167010729 N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246 1415167010730 stage II sporulation protein R; Region: spore_II_R; TIGR02837 1415167010731 HemK family putative methylases; Region: hemK_fam; TIGR00536 1415167010732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167010733 S-adenosylmethionine binding site [chemical binding]; other site 1415167010734 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1415167010735 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1415167010736 RF-1 domain; Region: RF-1; pfam00472 1415167010737 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1415167010738 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167010739 putative metal binding site [ion binding]; other site 1415167010740 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1415167010741 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1415167010742 DNA binding residues [nucleotide binding] 1415167010743 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1415167010744 malate dehydrogenase; Provisional; Region: PRK13529 1415167010745 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1415167010746 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1415167010747 NAD(P) binding site [chemical binding]; other site 1415167010748 thymidine kinase; Provisional; Region: PRK04296 1415167010749 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1415167010750 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1415167010751 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1415167010752 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1415167010753 RNA binding site [nucleotide binding]; other site 1415167010754 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1415167010755 multimer interface [polypeptide binding]; other site 1415167010756 Walker A motif; other site 1415167010757 ATP binding site [chemical binding]; other site 1415167010758 Walker B motif; other site 1415167010759 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1415167010760 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1415167010761 putative active site [active] 1415167010762 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1415167010763 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1415167010764 hinge; other site 1415167010765 active site 1415167010766 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1415167010767 active site 1415167010768 intersubunit interactions; other site 1415167010769 catalytic residue [active] 1415167010770 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1415167010771 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1415167010772 intersubunit interface [polypeptide binding]; other site 1415167010773 active site 1415167010774 zinc binding site [ion binding]; other site 1415167010775 Na+ binding site [ion binding]; other site 1415167010776 Response regulator receiver domain; Region: Response_reg; pfam00072 1415167010777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167010778 active site 1415167010779 phosphorylation site [posttranslational modification] 1415167010780 intermolecular recognition site; other site 1415167010781 dimerization interface [polypeptide binding]; other site 1415167010782 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1415167010783 CTP synthetase; Validated; Region: pyrG; PRK05380 1415167010784 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1415167010785 Catalytic site [active] 1415167010786 active site 1415167010787 UTP binding site [chemical binding]; other site 1415167010788 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1415167010789 active site 1415167010790 putative oxyanion hole; other site 1415167010791 catalytic triad [active] 1415167010792 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1415167010793 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1415167010794 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1415167010795 FAD binding site [chemical binding]; other site 1415167010796 homotetramer interface [polypeptide binding]; other site 1415167010797 substrate binding pocket [chemical binding]; other site 1415167010798 catalytic base [active] 1415167010799 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1415167010800 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1415167010801 Cysteine-rich domain; Region: CCG; pfam02754 1415167010802 Cysteine-rich domain; Region: CCG; pfam02754 1415167010803 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1415167010804 putative active site [active] 1415167010805 catalytic site [active] 1415167010806 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1415167010807 PLD-like domain; Region: PLDc_2; pfam13091 1415167010808 putative active site [active] 1415167010809 catalytic site [active] 1415167010810 UV damage endonuclease UvdE; Region: uvde; TIGR00629 1415167010811 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1415167010812 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1415167010813 folate binding site [chemical binding]; other site 1415167010814 NADP+ binding site [chemical binding]; other site 1415167010815 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1415167010816 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1415167010817 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1415167010818 Walker A/P-loop; other site 1415167010819 ATP binding site [chemical binding]; other site 1415167010820 Q-loop/lid; other site 1415167010821 ABC transporter signature motif; other site 1415167010822 Walker B; other site 1415167010823 D-loop; other site 1415167010824 H-loop/switch region; other site 1415167010825 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1415167010826 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1415167010827 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1415167010828 putative active site [active] 1415167010829 catalytic site [active] 1415167010830 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1415167010831 putative active site [active] 1415167010832 catalytic site [active] 1415167010833 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1415167010834 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1415167010835 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1415167010836 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1415167010837 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1415167010838 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1415167010839 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1415167010840 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1415167010841 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1415167010842 molybdopterin cofactor binding site; other site 1415167010843 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1415167010844 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1415167010845 ligand binding site [chemical binding]; other site 1415167010846 flexible hinge region; other site 1415167010847 YwiC-like protein; Region: YwiC; pfam14256 1415167010848 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1415167010849 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1415167010850 ligand binding site [chemical binding]; other site 1415167010851 flexible hinge region; other site 1415167010852 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1415167010853 putative switch regulator; other site 1415167010854 non-specific DNA interactions [nucleotide binding]; other site 1415167010855 DNA binding site [nucleotide binding] 1415167010856 sequence specific DNA binding site [nucleotide binding]; other site 1415167010857 putative cAMP binding site [chemical binding]; other site 1415167010858 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1415167010859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167010860 putative substrate translocation pore; other site 1415167010861 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1415167010862 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1415167010863 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1415167010864 active site 1415167010865 HIGH motif; other site 1415167010866 KMSK motif region; other site 1415167010867 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1415167010868 tRNA binding surface [nucleotide binding]; other site 1415167010869 anticodon binding site; other site 1415167010870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1415167010871 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 1415167010872 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1415167010873 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1415167010874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167010875 FeS/SAM binding site; other site 1415167010876 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1415167010877 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1415167010878 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1415167010879 Walker A/P-loop; other site 1415167010880 ATP binding site [chemical binding]; other site 1415167010881 Q-loop/lid; other site 1415167010882 ABC transporter signature motif; other site 1415167010883 Walker B; other site 1415167010884 D-loop; other site 1415167010885 H-loop/switch region; other site 1415167010886 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1415167010887 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1415167010888 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1415167010889 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1415167010890 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1415167010891 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1415167010892 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1415167010893 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1415167010894 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1415167010895 binding surface 1415167010896 TPR motif; other site 1415167010897 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1415167010898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167010899 TPR motif; other site 1415167010900 binding surface 1415167010901 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1415167010902 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1415167010903 putative deacylase active site [active] 1415167010904 agmatinase; Region: agmatinase; TIGR01230 1415167010905 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1415167010906 putative active site [active] 1415167010907 Mn binding site [ion binding]; other site 1415167010908 spermidine synthase; Provisional; Region: PRK00811 1415167010909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167010910 Transglycosylase; Region: Transgly; pfam00912 1415167010911 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1415167010912 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1415167010913 YwhD family; Region: YwhD; pfam08741 1415167010914 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1415167010915 Peptidase family M50; Region: Peptidase_M50; pfam02163 1415167010916 active site 1415167010917 putative substrate binding region [chemical binding]; other site 1415167010918 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1415167010919 active site 1 [active] 1415167010920 dimer interface [polypeptide binding]; other site 1415167010921 hexamer interface [polypeptide binding]; other site 1415167010922 active site 2 [active] 1415167010923 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167010924 MarR family; Region: MarR; pfam01047 1415167010925 MarR family; Region: MarR_2; cl17246 1415167010926 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 1415167010927 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1415167010928 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1415167010929 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1415167010930 active site 1415167010931 dimer interface [polypeptide binding]; other site 1415167010932 motif 1; other site 1415167010933 motif 2; other site 1415167010934 motif 3; other site 1415167010935 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1415167010936 anticodon binding site; other site 1415167010937 benzoate transport; Region: 2A0115; TIGR00895 1415167010938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167010939 putative substrate translocation pore; other site 1415167010940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167010941 Rrf2 family protein; Region: rrf2_super; TIGR00738 1415167010942 Transcriptional regulator; Region: Rrf2; pfam02082 1415167010943 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1415167010944 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1415167010945 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1415167010946 Zn2+ binding site [ion binding]; other site 1415167010947 Mg2+ binding site [ion binding]; other site 1415167010948 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1415167010949 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1415167010950 EamA-like transporter family; Region: EamA; pfam00892 1415167010951 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1415167010952 EamA-like transporter family; Region: EamA; pfam00892 1415167010953 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1415167010954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167010955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167010956 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1415167010957 putative dimerization interface [polypeptide binding]; other site 1415167010958 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1415167010959 putative heme peroxidase; Provisional; Region: PRK12276 1415167010960 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1415167010961 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1415167010962 putative NAD(P) binding site [chemical binding]; other site 1415167010963 putative active site [active] 1415167010964 transaminase; Reviewed; Region: PRK08068 1415167010965 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1415167010966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167010967 homodimer interface [polypeptide binding]; other site 1415167010968 catalytic residue [active] 1415167010969 H+ Antiporter protein; Region: 2A0121; TIGR00900 1415167010970 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1415167010971 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1415167010972 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1415167010973 classical (c) SDRs; Region: SDR_c; cd05233 1415167010974 NAD(P) binding site [chemical binding]; other site 1415167010975 active site 1415167010976 Cupin domain; Region: Cupin_2; pfam07883 1415167010977 Cupin domain; Region: Cupin_2; pfam07883 1415167010978 Prephenate dehydratase; Region: PDT; pfam00800 1415167010979 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1415167010980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167010981 putative substrate translocation pore; other site 1415167010982 S-methylmethionine transporter; Provisional; Region: PRK11387 1415167010983 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1415167010984 putative metal binding site [ion binding]; other site 1415167010985 putative dimer interface [polypeptide binding]; other site 1415167010986 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1415167010987 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1415167010988 Glutamate binding site [chemical binding]; other site 1415167010989 homodimer interface [polypeptide binding]; other site 1415167010990 NAD binding site [chemical binding]; other site 1415167010991 catalytic residues [active] 1415167010992 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1415167010993 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1415167010994 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1415167010995 NAD(P) binding site [chemical binding]; other site 1415167010996 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1415167010997 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1415167010998 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 1415167010999 NAD binding site [chemical binding]; other site 1415167011000 substrate binding site [chemical binding]; other site 1415167011001 homodimer interface [polypeptide binding]; other site 1415167011002 active site 1415167011003 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1415167011004 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1415167011005 substrate binding site; other site 1415167011006 tetramer interface; other site 1415167011007 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1415167011008 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1415167011009 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1415167011010 ligand binding site; other site 1415167011011 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1415167011012 NeuB family; Region: NeuB; pfam03102 1415167011013 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1415167011014 NeuB binding interface [polypeptide binding]; other site 1415167011015 putative substrate binding site [chemical binding]; other site 1415167011016 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1415167011017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167011018 Coenzyme A binding pocket [chemical binding]; other site 1415167011019 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1415167011020 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1415167011021 inhibitor-cofactor binding pocket; inhibition site 1415167011022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1415167011023 catalytic residue [active] 1415167011024 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1415167011025 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1415167011026 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1415167011027 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1415167011028 active site 1415167011029 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1415167011030 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1415167011031 Permease family; Region: Xan_ur_permease; pfam00860 1415167011032 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1415167011033 ligand binding site [chemical binding]; other site 1415167011034 active site 1415167011035 UGI interface [polypeptide binding]; other site 1415167011036 catalytic site [active] 1415167011037 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1415167011038 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1415167011039 active site 1415167011040 Predicted transcriptional regulators [Transcription]; Region: COG1695 1415167011041 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1415167011042 putative DNA binding site [nucleotide binding]; other site 1415167011043 putative Zn2+ binding site [ion binding]; other site 1415167011044 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1415167011045 dimer interface [polypeptide binding]; other site 1415167011046 substrate binding site [chemical binding]; other site 1415167011047 ATP binding site [chemical binding]; other site 1415167011048 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1415167011049 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1415167011050 substrate binding [chemical binding]; other site 1415167011051 active site 1415167011052 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1415167011053 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1415167011054 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1415167011055 active site turn [active] 1415167011056 phosphorylation site [posttranslational modification] 1415167011057 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1415167011058 formate/nitrite transporter; Region: fnt; TIGR00790 1415167011059 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1415167011060 CAT RNA binding domain; Region: CAT_RBD; smart01061 1415167011061 PRD domain; Region: PRD; pfam00874 1415167011062 PRD domain; Region: PRD; pfam00874 1415167011063 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1415167011064 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1415167011065 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1415167011066 putative active site [active] 1415167011067 catalytic triad [active] 1415167011068 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1415167011069 PA/protease domain interface [polypeptide binding]; other site 1415167011070 putative integrin binding motif; other site 1415167011071 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1415167011072 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1415167011073 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1415167011074 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1415167011075 Bacterial protein of unknown function (HtrL_YibB); Region: HtrL_YibB; cl08171 1415167011076 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1415167011077 dimer interface [polypeptide binding]; other site 1415167011078 FMN binding site [chemical binding]; other site 1415167011079 NADPH bind site [chemical binding]; other site 1415167011080 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1415167011081 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1415167011082 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1415167011083 Subunit I/III interface [polypeptide binding]; other site 1415167011084 Subunit III/IV interface [polypeptide binding]; other site 1415167011085 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1415167011086 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1415167011087 D-pathway; other site 1415167011088 Putative ubiquinol binding site [chemical binding]; other site 1415167011089 Low-spin heme (heme b) binding site [chemical binding]; other site 1415167011090 Putative water exit pathway; other site 1415167011091 Binuclear center (heme o3/CuB) [ion binding]; other site 1415167011092 K-pathway; other site 1415167011093 Putative proton exit pathway; other site 1415167011094 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1415167011095 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1415167011096 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1415167011097 Predicted membrane protein [Function unknown]; Region: COG2261 1415167011098 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 1415167011099 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1415167011100 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1415167011101 galactokinase; Provisional; Region: PRK05322 1415167011102 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1415167011103 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1415167011104 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1415167011105 Predicted membrane protein [Function unknown]; Region: COG2246 1415167011106 GtrA-like protein; Region: GtrA; pfam04138 1415167011107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167011108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167011109 Anti-repressor SinI; Region: SinI; pfam08671 1415167011110 Predicted membrane protein [Function unknown]; Region: COG3162 1415167011111 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1415167011112 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1415167011113 catalytic residues [active] 1415167011114 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1415167011115 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1415167011116 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1415167011117 Imelysin; Region: Peptidase_M75; pfam09375 1415167011118 FTR1 family protein; Region: TIGR00145 1415167011119 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1415167011120 thiamine phosphate binding site [chemical binding]; other site 1415167011121 active site 1415167011122 pyrophosphate binding site [ion binding]; other site 1415167011123 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1415167011124 substrate binding site [chemical binding]; other site 1415167011125 multimerization interface [polypeptide binding]; other site 1415167011126 ATP binding site [chemical binding]; other site 1415167011127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167011128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167011129 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1415167011130 putative dimerization interface [polypeptide binding]; other site 1415167011131 holin-like protein; Validated; Region: PRK01658 1415167011132 TIGR00659 family protein; Region: TIGR00659 1415167011133 sugar efflux transporter; Region: 2A0120; TIGR00899 1415167011134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167011135 putative substrate translocation pore; other site 1415167011136 conserved hypothetical protein; Region: TIGR03833 1415167011137 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1415167011138 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1415167011139 putative RNA binding site [nucleotide binding]; other site 1415167011140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167011141 S-adenosylmethionine binding site [chemical binding]; other site 1415167011142 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167011143 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1415167011144 active site 1415167011145 metal binding site [ion binding]; metal-binding site 1415167011146 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1415167011147 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1415167011148 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1415167011149 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1415167011150 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1415167011151 active site 1415167011152 catalytic residues [active] 1415167011153 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1415167011154 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1415167011155 active site turn [active] 1415167011156 phosphorylation site [posttranslational modification] 1415167011157 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1415167011158 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1415167011159 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1415167011160 PRD domain; Region: PRD; pfam00874 1415167011161 PRD domain; Region: PRD; pfam00874 1415167011162 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1415167011163 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1415167011164 Ligand binding site; other site 1415167011165 metal-binding site 1415167011166 Predicted integral membrane protein [Function unknown]; Region: COG5522 1415167011167 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167011168 MarR family; Region: MarR; pfam01047 1415167011169 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1415167011170 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1415167011171 active site 1415167011172 HIGH motif; other site 1415167011173 dimer interface [polypeptide binding]; other site 1415167011174 KMSKS motif; other site 1415167011175 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1415167011176 RNA binding surface [nucleotide binding]; other site 1415167011177 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1415167011178 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1415167011179 PA/protease domain interface [polypeptide binding]; other site 1415167011180 putative integrin binding motif; other site 1415167011181 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1415167011182 Peptidase family M28; Region: Peptidase_M28; pfam04389 1415167011183 metal binding site [ion binding]; metal-binding site 1415167011184 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1415167011185 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1415167011186 synthetase active site [active] 1415167011187 NTP binding site [chemical binding]; other site 1415167011188 metal binding site [ion binding]; metal-binding site 1415167011189 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1415167011190 UbiA prenyltransferase family; Region: UbiA; pfam01040 1415167011191 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1415167011192 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 1415167011193 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1415167011194 acyl-activating enzyme (AAE) consensus motif; other site 1415167011195 AMP binding site [chemical binding]; other site 1415167011196 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1415167011197 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1415167011198 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1415167011199 DltD N-terminal region; Region: DltD_N; pfam04915 1415167011200 DltD central region; Region: DltD_M; pfam04918 1415167011201 DltD C-terminal region; Region: DltD_C; pfam04914 1415167011202 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1415167011203 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1415167011204 putative NAD(P) binding site [chemical binding]; other site 1415167011205 active site 1415167011206 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1415167011207 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1415167011208 homodimer interface [polypeptide binding]; other site 1415167011209 substrate-cofactor binding pocket; other site 1415167011210 catalytic residue [active] 1415167011211 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1415167011212 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1415167011213 NAD binding site [chemical binding]; other site 1415167011214 sugar binding site [chemical binding]; other site 1415167011215 divalent metal binding site [ion binding]; other site 1415167011216 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1415167011217 dimer interface [polypeptide binding]; other site 1415167011218 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1415167011219 methionine cluster; other site 1415167011220 active site 1415167011221 phosphorylation site [posttranslational modification] 1415167011222 metal binding site [ion binding]; metal-binding site 1415167011223 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1415167011224 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1415167011225 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1415167011226 active site 1415167011227 P-loop; other site 1415167011228 phosphorylation site [posttranslational modification] 1415167011229 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1415167011230 HTH domain; Region: HTH_11; pfam08279 1415167011231 Mga helix-turn-helix domain; Region: Mga; pfam05043 1415167011232 PRD domain; Region: PRD; pfam00874 1415167011233 PRD domain; Region: PRD; pfam00874 1415167011234 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1415167011235 active site 1415167011236 P-loop; other site 1415167011237 phosphorylation site [posttranslational modification] 1415167011238 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1415167011239 active site 1415167011240 phosphorylation site [posttranslational modification] 1415167011241 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1415167011242 active site 1415167011243 DNA binding site [nucleotide binding] 1415167011244 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1415167011245 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1415167011246 tetramer interface [polypeptide binding]; other site 1415167011247 heme binding pocket [chemical binding]; other site 1415167011248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167011249 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167011250 putative substrate translocation pore; other site 1415167011251 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1415167011252 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1415167011253 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1415167011254 Walker A/P-loop; other site 1415167011255 ATP binding site [chemical binding]; other site 1415167011256 Q-loop/lid; other site 1415167011257 ABC transporter signature motif; other site 1415167011258 Walker B; other site 1415167011259 D-loop; other site 1415167011260 H-loop/switch region; other site 1415167011261 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1415167011262 Exoribonuclease II [Transcription]; Region: Rnb; COG4776 1415167011263 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 1415167011264 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1415167011265 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167011266 DNA binding residues [nucleotide binding] 1415167011267 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1415167011268 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1415167011269 Na binding site [ion binding]; other site 1415167011270 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1415167011271 putative substrate binding site [chemical binding]; other site 1415167011272 putative ATP binding site [chemical binding]; other site 1415167011273 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1415167011274 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1415167011275 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1415167011276 Walker A/P-loop; other site 1415167011277 ATP binding site [chemical binding]; other site 1415167011278 Q-loop/lid; other site 1415167011279 ABC transporter signature motif; other site 1415167011280 Walker B; other site 1415167011281 D-loop; other site 1415167011282 H-loop/switch region; other site 1415167011283 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1415167011284 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1415167011285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1415167011286 ATP binding site [chemical binding]; other site 1415167011287 Q-loop/lid; other site 1415167011288 ABC transporter signature motif; other site 1415167011289 Walker B; other site 1415167011290 D-loop; other site 1415167011291 H-loop/switch region; other site 1415167011292 cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203 1415167011293 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1415167011294 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1415167011295 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1415167011296 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1415167011297 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1415167011298 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1415167011299 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1415167011300 putative active site [active] 1415167011301 putative metal binding site [ion binding]; other site 1415167011302 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1415167011303 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1415167011304 Walker A/P-loop; other site 1415167011305 ATP binding site [chemical binding]; other site 1415167011306 Q-loop/lid; other site 1415167011307 ABC transporter signature motif; other site 1415167011308 Walker B; other site 1415167011309 D-loop; other site 1415167011310 H-loop/switch region; other site 1415167011311 TOBE domain; Region: TOBE; pfam03459 1415167011312 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1415167011313 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1415167011314 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1415167011315 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1415167011316 NAD(P) binding site [chemical binding]; other site 1415167011317 catalytic residues [active] 1415167011318 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1415167011319 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167011320 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1415167011321 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1415167011322 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1415167011323 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1415167011324 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1415167011325 UDP-glucose 4-epimerase; Region: PLN02240 1415167011326 NAD binding site [chemical binding]; other site 1415167011327 homodimer interface [polypeptide binding]; other site 1415167011328 active site 1415167011329 substrate binding site [chemical binding]; other site 1415167011330 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1415167011331 substrate binding site [chemical binding]; other site 1415167011332 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167011333 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167011334 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1415167011335 dimerization interface [polypeptide binding]; other site 1415167011336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1415167011337 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1415167011338 Histidine kinase; Region: HisKA_3; pfam07730 1415167011339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167011340 ATP binding site [chemical binding]; other site 1415167011341 Mg2+ binding site [ion binding]; other site 1415167011342 G-X-G motif; other site 1415167011343 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1415167011344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167011345 active site 1415167011346 phosphorylation site [posttranslational modification] 1415167011347 intermolecular recognition site; other site 1415167011348 dimerization interface [polypeptide binding]; other site 1415167011349 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1415167011350 DNA binding residues [nucleotide binding] 1415167011351 dimerization interface [polypeptide binding]; other site 1415167011352 peptidase T; Region: peptidase-T; TIGR01882 1415167011353 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1415167011354 metal binding site [ion binding]; metal-binding site 1415167011355 dimer interface [polypeptide binding]; other site 1415167011356 Uncharacterized conserved protein [Function unknown]; Region: COG4894 1415167011357 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1415167011358 substrate binding site [chemical binding]; other site 1415167011359 THF binding site; other site 1415167011360 zinc-binding site [ion binding]; other site 1415167011361 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1415167011362 substrate binding site [chemical binding]; other site 1415167011363 THF binding site; other site 1415167011364 zinc-binding site [ion binding]; other site 1415167011365 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1415167011366 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1415167011367 NAD binding site [chemical binding]; other site 1415167011368 homotetramer interface [polypeptide binding]; other site 1415167011369 homodimer interface [polypeptide binding]; other site 1415167011370 substrate binding site [chemical binding]; other site 1415167011371 active site 1415167011372 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1415167011373 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1415167011374 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1415167011375 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1415167011376 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1415167011377 S-adenosylmethionine binding site [chemical binding]; other site 1415167011378 nucleoside transporter; Region: nupC; TIGR00804 1415167011379 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1415167011380 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1415167011381 hydroperoxidase II; Provisional; Region: katE; PRK11249 1415167011382 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1415167011383 tetramer interface [polypeptide binding]; other site 1415167011384 heme binding pocket [chemical binding]; other site 1415167011385 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1415167011386 domain interactions; other site 1415167011387 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1415167011388 Citrate transporter; Region: CitMHS; pfam03600 1415167011389 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1415167011390 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1415167011391 active site 1415167011392 active site 1415167011393 catalytic residues [active] 1415167011394 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1415167011395 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1415167011396 PRD domain; Region: PRD; pfam00874 1415167011397 PRD domain; Region: PRD; pfam00874 1415167011398 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1415167011399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167011400 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1415167011401 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1415167011402 ATP binding site [chemical binding]; other site 1415167011403 Mg++ binding site [ion binding]; other site 1415167011404 motif III; other site 1415167011405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1415167011406 nucleotide binding region [chemical binding]; other site 1415167011407 ATP-binding site [chemical binding]; other site 1415167011408 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1415167011409 RNA binding site [nucleotide binding]; other site 1415167011410 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1415167011411 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1415167011412 active site 1415167011413 catalytic triad [active] 1415167011414 YxiJ-like protein; Region: YxiJ; pfam14176 1415167011415 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1415167011416 RHS Repeat; Region: RHS_repeat; pfam05593 1415167011417 RHS Repeat; Region: RHS_repeat; pfam05593 1415167011418 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1415167011419 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1415167011420 RHS Repeat; Region: RHS_repeat; pfam05593 1415167011421 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1415167011422 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1415167011423 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1415167011424 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1415167011425 EamA-like transporter family; Region: EamA; pfam00892 1415167011426 EamA-like transporter family; Region: EamA; pfam00892 1415167011427 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1415167011428 Ligand Binding Site [chemical binding]; other site 1415167011429 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1415167011430 beta-galactosidase; Region: BGL; TIGR03356 1415167011431 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1415167011432 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1415167011433 active site turn [active] 1415167011434 phosphorylation site [posttranslational modification] 1415167011435 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1415167011436 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1415167011437 HPr interaction site; other site 1415167011438 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1415167011439 active site 1415167011440 phosphorylation site [posttranslational modification] 1415167011441 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1415167011442 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1415167011443 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1415167011444 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1415167011445 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1415167011446 substrate binding site [chemical binding]; other site 1415167011447 active site 1415167011448 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1415167011449 hexamer interface [polypeptide binding]; other site 1415167011450 RNA binding site [nucleotide binding]; other site 1415167011451 Histidine-zinc binding site [chemical binding]; other site 1415167011452 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1415167011453 active sites [active] 1415167011454 tetramer interface [polypeptide binding]; other site 1415167011455 urocanate hydratase; Provisional; Region: PRK05414 1415167011456 imidazolonepropionase; Validated; Region: PRK09356 1415167011457 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1415167011458 active site 1415167011459 Agmatinase-like family; Region: Agmatinase-like; cd09990 1415167011460 agmatinase; Region: agmatinase; TIGR01230 1415167011461 active site 1415167011462 oligomer interface [polypeptide binding]; other site 1415167011463 Mn binding site [ion binding]; other site 1415167011464 S-methylmethionine transporter; Provisional; Region: PRK11387 1415167011465 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1415167011466 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1415167011467 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1415167011468 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1415167011469 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1415167011470 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1415167011471 Nucleoside recognition; Region: Gate; pfam07670 1415167011472 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1415167011473 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1415167011474 intersubunit interface [polypeptide binding]; other site 1415167011475 active site 1415167011476 catalytic residue [active] 1415167011477 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1415167011478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1415167011479 DNA binding residues [nucleotide binding] 1415167011480 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1415167011481 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1415167011482 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1415167011483 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1415167011484 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1415167011485 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 1415167011486 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1415167011487 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1415167011488 metal binding site [ion binding]; metal-binding site 1415167011489 dimer interface [polypeptide binding]; other site 1415167011490 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1415167011491 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1415167011492 Walker A/P-loop; other site 1415167011493 ATP binding site [chemical binding]; other site 1415167011494 Q-loop/lid; other site 1415167011495 ABC transporter signature motif; other site 1415167011496 Walker B; other site 1415167011497 D-loop; other site 1415167011498 H-loop/switch region; other site 1415167011499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1415167011500 dimer interface [polypeptide binding]; other site 1415167011501 conserved gate region; other site 1415167011502 putative PBP binding loops; other site 1415167011503 ABC-ATPase subunit interface; other site 1415167011504 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1415167011505 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1415167011506 substrate binding pocket [chemical binding]; other site 1415167011507 membrane-bound complex binding site; other site 1415167011508 hinge residues; other site 1415167011509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167011510 Coenzyme A binding pocket [chemical binding]; other site 1415167011511 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1415167011512 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1415167011513 active site 1415167011514 non-prolyl cis peptide bond; other site 1415167011515 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1415167011516 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1415167011517 active site 1415167011518 sugar phosphate phosphatase; Provisional; Region: PRK10513 1415167011519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167011520 active site 1415167011521 motif I; other site 1415167011522 motif II; other site 1415167011523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1415167011524 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1415167011525 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1415167011526 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1415167011527 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1415167011528 putative ligand binding residues [chemical binding]; other site 1415167011529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1415167011530 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1415167011531 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1415167011532 Walker A/P-loop; other site 1415167011533 ATP binding site [chemical binding]; other site 1415167011534 Q-loop/lid; other site 1415167011535 ABC transporter signature motif; other site 1415167011536 Walker B; other site 1415167011537 D-loop; other site 1415167011538 H-loop/switch region; other site 1415167011539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1415167011540 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1415167011541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167011542 ATP binding site [chemical binding]; other site 1415167011543 Mg2+ binding site [ion binding]; other site 1415167011544 G-X-G motif; other site 1415167011545 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1415167011546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167011547 active site 1415167011548 phosphorylation site [posttranslational modification] 1415167011549 intermolecular recognition site; other site 1415167011550 dimerization interface [polypeptide binding]; other site 1415167011551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1415167011552 DNA binding site [nucleotide binding] 1415167011553 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1415167011554 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1415167011555 intersubunit interface [polypeptide binding]; other site 1415167011556 active site 1415167011557 zinc binding site [ion binding]; other site 1415167011558 Na+ binding site [ion binding]; other site 1415167011559 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1415167011560 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1415167011561 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1415167011562 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1415167011563 DNA interaction; other site 1415167011564 Metal-binding active site; metal-binding site 1415167011565 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1415167011566 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1415167011567 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1415167011568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167011569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167011570 putative substrate translocation pore; other site 1415167011571 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1415167011572 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1415167011573 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1415167011574 PYR/PP interface [polypeptide binding]; other site 1415167011575 dimer interface [polypeptide binding]; other site 1415167011576 TPP binding site [chemical binding]; other site 1415167011577 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1415167011578 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1415167011579 TPP-binding site; other site 1415167011580 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1415167011581 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1415167011582 substrate binding site [chemical binding]; other site 1415167011583 ATP binding site [chemical binding]; other site 1415167011584 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1415167011585 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1415167011586 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1415167011587 tetrameric interface [polypeptide binding]; other site 1415167011588 NAD binding site [chemical binding]; other site 1415167011589 catalytic residues [active] 1415167011590 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1415167011591 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1415167011592 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1415167011593 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1415167011594 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1415167011595 active site 1415167011596 catalytic tetrad [active] 1415167011597 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1415167011598 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1415167011599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167011600 putative substrate translocation pore; other site 1415167011601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167011602 heat shock protein 90; Provisional; Region: PRK05218 1415167011603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167011604 ATP binding site [chemical binding]; other site 1415167011605 Mg2+ binding site [ion binding]; other site 1415167011606 G-X-G motif; other site 1415167011607 short chain dehydrogenase; Validated; Region: PRK08589 1415167011608 classical (c) SDRs; Region: SDR_c; cd05233 1415167011609 NAD(P) binding site [chemical binding]; other site 1415167011610 active site 1415167011611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167011612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167011613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167011614 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1415167011615 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1415167011616 NAD(P) binding site [chemical binding]; other site 1415167011617 catalytic residues [active] 1415167011618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167011619 Coenzyme A binding pocket [chemical binding]; other site 1415167011620 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1415167011621 Cupin-like domain; Region: Cupin_8; pfam13621 1415167011622 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1415167011623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167011624 S-adenosylmethionine binding site [chemical binding]; other site 1415167011625 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1415167011626 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1415167011627 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1415167011628 active site 1415167011629 dimer interface [polypeptide binding]; other site 1415167011630 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1415167011631 Ligand Binding Site [chemical binding]; other site 1415167011632 Molecular Tunnel; other site 1415167011633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167011634 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167011635 putative substrate translocation pore; other site 1415167011636 RDD family; Region: RDD; pfam06271 1415167011637 Predicted membrane protein [Function unknown]; Region: COG2311 1415167011638 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1415167011639 Cupin domain; Region: Cupin_2; pfam07883 1415167011640 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1415167011641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1415167011642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1415167011643 short chain dehydrogenase; Provisional; Region: PRK07109 1415167011644 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1415167011645 putative NAD(P) binding site [chemical binding]; other site 1415167011646 active site 1415167011647 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167011648 MarR family; Region: MarR; pfam01047 1415167011649 LrgA family; Region: LrgA; cl00608 1415167011650 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1415167011651 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1415167011652 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1415167011653 Glycerate kinase family; Region: Gly_kinase; pfam02595 1415167011654 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1415167011655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167011656 DNA-binding site [nucleotide binding]; DNA binding site 1415167011657 FCD domain; Region: FCD; pfam07729 1415167011658 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1415167011659 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1415167011660 N- and C-terminal domain interface [polypeptide binding]; other site 1415167011661 active site 1415167011662 catalytic site [active] 1415167011663 metal binding site [ion binding]; metal-binding site 1415167011664 carbohydrate binding site [chemical binding]; other site 1415167011665 ATP binding site [chemical binding]; other site 1415167011666 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1415167011667 gluconate transporter; Region: gntP; TIGR00791 1415167011668 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 1415167011669 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1415167011670 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1415167011671 peroxiredoxin; Region: AhpC; TIGR03137 1415167011672 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1415167011673 dimer interface [polypeptide binding]; other site 1415167011674 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1415167011675 catalytic triad [active] 1415167011676 peroxidatic and resolving cysteines [active] 1415167011677 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1415167011678 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1415167011679 catalytic residue [active] 1415167011680 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1415167011681 catalytic residues [active] 1415167011682 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1415167011683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1415167011684 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1415167011685 beta-galactosidase; Region: BGL; TIGR03356 1415167011686 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1415167011687 HPr interaction site; other site 1415167011688 active site 1415167011689 phosphorylation site [posttranslational modification] 1415167011690 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1415167011691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1415167011692 DNA-binding site [nucleotide binding]; DNA binding site 1415167011693 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1415167011694 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1415167011695 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1415167011696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1415167011697 Walker A/P-loop; other site 1415167011698 ATP binding site [chemical binding]; other site 1415167011699 Q-loop/lid; other site 1415167011700 ABC transporter signature motif; other site 1415167011701 Walker B; other site 1415167011702 D-loop; other site 1415167011703 H-loop/switch region; other site 1415167011704 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 1415167011705 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1415167011706 FeS/SAM binding site; other site 1415167011707 exported signaling peptide, YydF/SAG_2028 family; Region: expor_sig_YdyF; TIGR04077 1415167011708 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 1415167011709 Predicted ATPase [General function prediction only]; Region: COG5293 1415167011710 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 1415167011711 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1415167011712 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1415167011713 putative active site [active] 1415167011714 putative metal binding site [ion binding]; other site 1415167011715 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1415167011716 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1415167011717 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1415167011718 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1415167011719 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1415167011720 NAD binding site [chemical binding]; other site 1415167011721 catalytic Zn binding site [ion binding]; other site 1415167011722 structural Zn binding site [ion binding]; other site 1415167011723 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1415167011724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1415167011725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167011726 Coenzyme A binding pocket [chemical binding]; other site 1415167011727 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1415167011728 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1415167011729 binding surface 1415167011730 TPR motif; other site 1415167011731 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1415167011732 Arginase family; Region: Arginase; cd09989 1415167011733 agmatinase; Region: agmatinase; TIGR01230 1415167011734 active site 1415167011735 Mn binding site [ion binding]; other site 1415167011736 oligomer interface [polypeptide binding]; other site 1415167011737 S-methylmethionine transporter; Provisional; Region: PRK11387 1415167011738 PAS domain; Region: PAS; smart00091 1415167011739 PAS domain; Region: PAS_9; pfam13426 1415167011740 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1415167011741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1415167011742 Walker A motif; other site 1415167011743 ATP binding site [chemical binding]; other site 1415167011744 Walker B motif; other site 1415167011745 arginine finger; other site 1415167011746 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1415167011747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167011748 ATP binding site [chemical binding]; other site 1415167011749 G-X-G motif; other site 1415167011750 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1415167011751 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1415167011752 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1415167011753 protein binding site [polypeptide binding]; other site 1415167011754 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1415167011755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 1415167011756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1415167011757 YycH protein; Region: YycH; pfam07435 1415167011758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1415167011759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1415167011760 dimerization interface [polypeptide binding]; other site 1415167011761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1415167011762 putative active site [active] 1415167011763 heme pocket [chemical binding]; other site 1415167011764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1415167011765 dimer interface [polypeptide binding]; other site 1415167011766 phosphorylation site [posttranslational modification] 1415167011767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1415167011768 ATP binding site [chemical binding]; other site 1415167011769 Mg2+ binding site [ion binding]; other site 1415167011770 G-X-G motif; other site 1415167011771 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1415167011772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1415167011773 active site 1415167011774 phosphorylation site [posttranslational modification] 1415167011775 intermolecular recognition site; other site 1415167011776 dimerization interface [polypeptide binding]; other site 1415167011777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1415167011778 DNA binding site [nucleotide binding] 1415167011779 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1415167011780 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1415167011781 GDP-binding site [chemical binding]; other site 1415167011782 ACT binding site; other site 1415167011783 IMP binding site; other site 1415167011784 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167011785 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1415167011786 active site 1415167011787 replicative DNA helicase; Provisional; Region: PRK05748 1415167011788 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1415167011789 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1415167011790 Walker A motif; other site 1415167011791 ATP binding site [chemical binding]; other site 1415167011792 Walker B motif; other site 1415167011793 DNA binding loops [nucleotide binding] 1415167011794 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1415167011795 YycC-like protein; Region: YycC; pfam14174 1415167011796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167011797 cyanate transporter; Region: CynX; TIGR00896 1415167011798 putative substrate translocation pore; other site 1415167011799 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1415167011800 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1415167011801 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1415167011802 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1415167011803 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1415167011804 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1415167011805 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1415167011806 diguanylate cyclase; Region: GGDEF; smart00267 1415167011807 DHH family; Region: DHH; pfam01368 1415167011808 DHHA1 domain; Region: DHHA1; pfam02272 1415167011809 Predicted membrane protein [Function unknown]; Region: COG4241 1415167011810 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1415167011811 Predicted transcriptional regulators [Transcription]; Region: COG1733 1415167011812 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1415167011813 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1415167011814 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1415167011815 DHHA2 domain; Region: DHHA2; pfam02833 1415167011816 ANTAR domain; Region: ANTAR; cl04297 1415167011817 D-galactonate transporter; Region: 2A0114; TIGR00893 1415167011818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167011819 putative substrate translocation pore; other site 1415167011820 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1415167011821 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 1415167011822 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 1415167011823 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1415167011824 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1415167011825 Walker A/P-loop; other site 1415167011826 ATP binding site [chemical binding]; other site 1415167011827 Q-loop/lid; other site 1415167011828 ABC transporter signature motif; other site 1415167011829 Walker B; other site 1415167011830 D-loop; other site 1415167011831 H-loop/switch region; other site 1415167011832 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 1415167011833 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1415167011834 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1415167011835 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1415167011836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167011837 putative substrate translocation pore; other site 1415167011838 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1415167011839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1415167011840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1415167011841 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1415167011842 putative dimerization interface [polypeptide binding]; other site 1415167011843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167011844 Coenzyme A binding pocket [chemical binding]; other site 1415167011845 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1415167011846 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1415167011847 MarR family; Region: MarR; pfam01047 1415167011848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167011849 Coenzyme A binding pocket [chemical binding]; other site 1415167011850 Predicted membrane protein [Function unknown]; Region: COG2364 1415167011851 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1415167011852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1415167011853 Coenzyme A binding pocket [chemical binding]; other site 1415167011854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1415167011855 RibD C-terminal domain; Region: RibD_C; cl17279 1415167011856 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1415167011857 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1415167011858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167011859 putative substrate translocation pore; other site 1415167011860 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1415167011861 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1415167011862 EamA-like transporter family; Region: EamA; pfam00892 1415167011863 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1415167011864 EamA-like transporter family; Region: EamA; pfam00892 1415167011865 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1415167011866 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1415167011867 catalytic residues [active] 1415167011868 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1415167011869 CAAX protease self-immunity; Region: Abi; pfam02517 1415167011870 benzoate transport; Region: 2A0115; TIGR00895 1415167011871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167011872 putative substrate translocation pore; other site 1415167011873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1415167011874 maltose O-acetyltransferase; Provisional; Region: PRK10092 1415167011875 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1415167011876 active site 1415167011877 substrate binding site [chemical binding]; other site 1415167011878 trimer interface [polypeptide binding]; other site 1415167011879 CoA binding site [chemical binding]; other site 1415167011880 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1415167011881 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1415167011882 putative metal binding site [ion binding]; other site 1415167011883 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1415167011884 DNA binding site [nucleotide binding] 1415167011885 domain linker motif; other site 1415167011886 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1415167011887 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1415167011888 putative dimerization interface [polypeptide binding]; other site 1415167011889 putative ligand binding site [chemical binding]; other site 1415167011890 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1415167011891 active site 1415167011892 putative catalytic site [active] 1415167011893 DNA binding site [nucleotide binding] 1415167011894 putative phosphate binding site [ion binding]; other site 1415167011895 metal binding site A [ion binding]; metal-binding site 1415167011896 AP binding site [nucleotide binding]; other site 1415167011897 metal binding site B [ion binding]; metal-binding site 1415167011898 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1415167011899 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1415167011900 dimer interface [polypeptide binding]; other site 1415167011901 ssDNA binding site [nucleotide binding]; other site 1415167011902 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1415167011903 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1415167011904 GTP-binding protein YchF; Reviewed; Region: PRK09601 1415167011905 YchF GTPase; Region: YchF; cd01900 1415167011906 G1 box; other site 1415167011907 GTP/Mg2+ binding site [chemical binding]; other site 1415167011908 Switch I region; other site 1415167011909 G2 box; other site 1415167011910 Switch II region; other site 1415167011911 G3 box; other site 1415167011912 G4 box; other site 1415167011913 G5 box; other site 1415167011914 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1415167011915 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1415167011916 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1415167011917 putative [4Fe-4S] binding site [ion binding]; other site 1415167011918 putative molybdopterin cofactor binding site [chemical binding]; other site 1415167011919 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1415167011920 molybdopterin cofactor binding site; other site 1415167011921 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1415167011922 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1415167011923 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1415167011924 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1415167011925 ParB-like nuclease domain; Region: ParB; smart00470 1415167011926 KorB domain; Region: KorB; pfam08535 1415167011927 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1415167011928 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1415167011929 P-loop; other site 1415167011930 Magnesium ion binding site [ion binding]; other site 1415167011931 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1415167011932 Magnesium ion binding site [ion binding]; other site 1415167011933 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1415167011934 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1415167011935 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1415167011936 ParB-like nuclease domain; Region: ParB; smart00470 1415167011937 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1415167011938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1415167011939 S-adenosylmethionine binding site [chemical binding]; other site 1415167011940 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1415167011941 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1415167011942 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1415167011943 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1415167011944 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1415167011945 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1415167011946 G1 box; other site 1415167011947 GTP/Mg2+ binding site [chemical binding]; other site 1415167011948 Switch I region; other site 1415167011949 G2 box; other site 1415167011950 Switch II region; other site 1415167011951 G3 box; other site 1415167011952 G4 box; other site 1415167011953 G5 box; other site 1415167011954 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1415167011955 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1415167011956 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1415167011957 G-X-X-G motif; other site 1415167011958 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1415167011959 RxxxH motif; other site 1415167011960 ribonuclease P; Reviewed; Region: rnpA; PRK00499