-- dump date 20140618_225402 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1052588000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1052588000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1052588000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588000004 Walker A motif; other site 1052588000005 ATP binding site [chemical binding]; other site 1052588000006 Walker B motif; other site 1052588000007 arginine finger; other site 1052588000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1052588000009 DnaA box-binding interface [nucleotide binding]; other site 1052588000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1052588000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1052588000012 putative DNA binding surface [nucleotide binding]; other site 1052588000013 dimer interface [polypeptide binding]; other site 1052588000014 beta-clamp/clamp loader binding surface; other site 1052588000015 beta-clamp/translesion DNA polymerase binding surface; other site 1052588000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1052588000017 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 1052588000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1052588000019 Walker A/P-loop; other site 1052588000020 ATP binding site [chemical binding]; other site 1052588000021 Q-loop/lid; other site 1052588000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588000023 ABC transporter signature motif; other site 1052588000024 Walker B; other site 1052588000025 D-loop; other site 1052588000026 H-loop/switch region; other site 1052588000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1052588000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588000029 ATP binding site [chemical binding]; other site 1052588000030 Mg2+ binding site [ion binding]; other site 1052588000031 G-X-G motif; other site 1052588000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1052588000033 anchoring element; other site 1052588000034 dimer interface [polypeptide binding]; other site 1052588000035 ATP binding site [chemical binding]; other site 1052588000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1052588000037 active site 1052588000038 putative metal-binding site [ion binding]; other site 1052588000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1052588000040 DNA gyrase subunit A; Validated; Region: PRK05560 1052588000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1052588000042 CAP-like domain; other site 1052588000043 active site 1052588000044 primary dimer interface [polypeptide binding]; other site 1052588000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588000051 YaaC-like Protein; Region: YaaC; pfam14175 1052588000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1052588000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1052588000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1052588000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1052588000056 active site 1052588000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1052588000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1052588000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1052588000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1052588000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1052588000062 active site 1052588000063 multimer interface [polypeptide binding]; other site 1052588000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1052588000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1052588000066 predicted active site [active] 1052588000067 catalytic triad [active] 1052588000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 1052588000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1052588000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1052588000071 dimer interface [polypeptide binding]; other site 1052588000072 active site 1052588000073 motif 1; other site 1052588000074 motif 2; other site 1052588000075 motif 3; other site 1052588000076 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1052588000077 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1052588000078 Substrate-binding site [chemical binding]; other site 1052588000079 Substrate specificity [chemical binding]; other site 1052588000080 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1052588000081 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1052588000082 Substrate-binding site [chemical binding]; other site 1052588000083 Substrate specificity [chemical binding]; other site 1052588000084 Isochorismatase family; Region: Isochorismatase; pfam00857 1052588000085 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1052588000086 catalytic triad [active] 1052588000087 conserved cis-peptide bond; other site 1052588000088 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1052588000089 nucleoside/Zn binding site; other site 1052588000090 dimer interface [polypeptide binding]; other site 1052588000091 catalytic motif [active] 1052588000092 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1052588000093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588000094 Walker A motif; other site 1052588000095 ATP binding site [chemical binding]; other site 1052588000096 Walker B motif; other site 1052588000097 arginine finger; other site 1052588000098 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1052588000099 hypothetical protein; Validated; Region: PRK00153 1052588000100 recombination protein RecR; Reviewed; Region: recR; PRK00076 1052588000101 RecR protein; Region: RecR; pfam02132 1052588000102 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1052588000103 putative active site [active] 1052588000104 putative metal-binding site [ion binding]; other site 1052588000105 tetramer interface [polypeptide binding]; other site 1052588000106 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1052588000107 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 1052588000108 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1052588000109 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1052588000110 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1052588000111 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 1052588000112 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1052588000113 homodimer interface [polypeptide binding]; other site 1052588000114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588000115 catalytic residue [active] 1052588000116 thymidylate kinase; Validated; Region: tmk; PRK00698 1052588000117 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1052588000118 TMP-binding site; other site 1052588000119 ATP-binding site [chemical binding]; other site 1052588000120 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1052588000121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 1052588000122 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1052588000123 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1052588000124 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1052588000125 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1052588000126 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1052588000127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588000128 S-adenosylmethionine binding site [chemical binding]; other site 1052588000129 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1052588000130 GIY-YIG motif/motif A; other site 1052588000131 putative active site [active] 1052588000132 putative metal binding site [ion binding]; other site 1052588000133 Predicted methyltransferases [General function prediction only]; Region: COG0313 1052588000134 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1052588000135 putative SAM binding site [chemical binding]; other site 1052588000136 putative homodimer interface [polypeptide binding]; other site 1052588000137 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1052588000138 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1052588000139 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1052588000140 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1052588000141 active site 1052588000142 HIGH motif; other site 1052588000143 KMSKS motif; other site 1052588000144 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1052588000145 tRNA binding surface [nucleotide binding]; other site 1052588000146 anticodon binding site; other site 1052588000147 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1052588000148 dimer interface [polypeptide binding]; other site 1052588000149 putative tRNA-binding site [nucleotide binding]; other site 1052588000150 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1052588000151 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1052588000152 active site 1052588000153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1052588000154 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052588000155 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052588000156 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052588000157 G5 domain; Region: G5; pfam07501 1052588000158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1052588000159 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1052588000160 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1052588000161 putative active site [active] 1052588000162 putative metal binding site [ion binding]; other site 1052588000163 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1052588000164 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1052588000165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588000166 S-adenosylmethionine binding site [chemical binding]; other site 1052588000167 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 1052588000168 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1052588000169 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052588000170 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1052588000171 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052588000172 pur operon repressor; Provisional; Region: PRK09213 1052588000173 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1052588000174 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588000175 active site 1052588000176 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1052588000177 homotrimer interaction site [polypeptide binding]; other site 1052588000178 putative active site [active] 1052588000179 regulatory protein SpoVG; Reviewed; Region: PRK13259 1052588000180 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1052588000181 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1052588000182 Substrate binding site; other site 1052588000183 Mg++ binding site; other site 1052588000184 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1052588000185 active site 1052588000186 substrate binding site [chemical binding]; other site 1052588000187 CoA binding site [chemical binding]; other site 1052588000188 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1052588000189 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1052588000190 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588000191 active site 1052588000192 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1052588000193 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1052588000194 5S rRNA interface [nucleotide binding]; other site 1052588000195 CTC domain interface [polypeptide binding]; other site 1052588000196 L16 interface [polypeptide binding]; other site 1052588000197 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1052588000198 putative active site [active] 1052588000199 catalytic residue [active] 1052588000200 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1052588000201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588000202 ATP-binding site [chemical binding]; other site 1052588000203 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1052588000204 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1052588000205 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1052588000206 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052588000207 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1052588000208 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1052588000209 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1052588000210 putative SAM binding site [chemical binding]; other site 1052588000211 putative homodimer interface [polypeptide binding]; other site 1052588000212 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1052588000213 homodimer interface [polypeptide binding]; other site 1052588000214 metal binding site [ion binding]; metal-binding site 1052588000215 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1052588000216 homodimer interface [polypeptide binding]; other site 1052588000217 active site 1052588000218 putative chemical substrate binding site [chemical binding]; other site 1052588000219 metal binding site [ion binding]; metal-binding site 1052588000220 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588000221 RNA binding surface [nucleotide binding]; other site 1052588000222 sporulation protein YabP; Region: spore_yabP; TIGR02892 1052588000223 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1052588000224 hypothetical protein; Provisional; Region: PRK08582 1052588000225 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1052588000226 RNA binding site [nucleotide binding]; other site 1052588000227 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1052588000228 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1052588000229 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1052588000230 metal ion-dependent adhesion site (MIDAS); other site 1052588000231 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1052588000232 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588000233 active site 1052588000234 ATP binding site [chemical binding]; other site 1052588000235 substrate binding site [chemical binding]; other site 1052588000236 activation loop (A-loop); other site 1052588000237 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1052588000238 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1052588000239 Ligand Binding Site [chemical binding]; other site 1052588000240 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1052588000241 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588000242 active site 1052588000243 FtsH Extracellular; Region: FtsH_ext; pfam06480 1052588000244 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1052588000245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588000246 Walker A motif; other site 1052588000247 ATP binding site [chemical binding]; other site 1052588000248 Walker B motif; other site 1052588000249 arginine finger; other site 1052588000250 Peptidase family M41; Region: Peptidase_M41; pfam01434 1052588000251 pantothenate kinase; Reviewed; Region: PRK13318 1052588000252 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1052588000253 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1052588000254 dimerization interface [polypeptide binding]; other site 1052588000255 domain crossover interface; other site 1052588000256 redox-dependent activation switch; other site 1052588000257 SurA N-terminal domain; Region: SurA_N_3; cl07813 1052588000258 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1052588000259 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1052588000260 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052588000261 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052588000262 dimer interface [polypeptide binding]; other site 1052588000263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588000264 catalytic residue [active] 1052588000265 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1052588000266 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1052588000267 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1052588000268 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1052588000269 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1052588000270 glutamine binding [chemical binding]; other site 1052588000271 catalytic triad [active] 1052588000272 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1052588000273 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1052588000274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588000275 catalytic residue [active] 1052588000276 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1052588000277 dihydropteroate synthase; Region: DHPS; TIGR01496 1052588000278 substrate binding pocket [chemical binding]; other site 1052588000279 dimer interface [polypeptide binding]; other site 1052588000280 inhibitor binding site; inhibition site 1052588000281 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1052588000282 homooctamer interface [polypeptide binding]; other site 1052588000283 active site 1052588000284 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1052588000285 catalytic center binding site [active] 1052588000286 ATP binding site [chemical binding]; other site 1052588000287 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052588000288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588000289 non-specific DNA binding site [nucleotide binding]; other site 1052588000290 salt bridge; other site 1052588000291 sequence-specific DNA binding site [nucleotide binding]; other site 1052588000292 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1052588000293 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1052588000294 FMN binding site [chemical binding]; other site 1052588000295 active site 1052588000296 catalytic residues [active] 1052588000297 substrate binding site [chemical binding]; other site 1052588000298 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1052588000299 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1052588000300 dimer interface [polypeptide binding]; other site 1052588000301 putative anticodon binding site; other site 1052588000302 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1052588000303 motif 1; other site 1052588000304 active site 1052588000305 motif 2; other site 1052588000306 motif 3; other site 1052588000307 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1052588000308 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1052588000309 UvrB/uvrC motif; Region: UVR; pfam02151 1052588000310 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1052588000311 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1052588000312 ADP binding site [chemical binding]; other site 1052588000313 phosphagen binding site; other site 1052588000314 substrate specificity loop; other site 1052588000315 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1052588000316 Clp amino terminal domain; Region: Clp_N; pfam02861 1052588000317 Clp amino terminal domain; Region: Clp_N; pfam02861 1052588000318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588000319 Walker A motif; other site 1052588000320 ATP binding site [chemical binding]; other site 1052588000321 Walker B motif; other site 1052588000322 arginine finger; other site 1052588000323 UvrB/uvrC motif; Region: UVR; pfam02151 1052588000324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588000325 Walker A motif; other site 1052588000326 ATP binding site [chemical binding]; other site 1052588000327 Walker B motif; other site 1052588000328 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1052588000329 DNA repair protein RadA; Provisional; Region: PRK11823 1052588000330 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1052588000331 Walker A motif/ATP binding site; other site 1052588000332 ATP binding site [chemical binding]; other site 1052588000333 Walker B motif; other site 1052588000334 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1052588000335 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1052588000336 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052588000337 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1052588000338 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1052588000339 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1052588000340 putative active site [active] 1052588000341 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1052588000342 substrate binding site; other site 1052588000343 dimer interface; other site 1052588000344 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1052588000345 homotrimer interaction site [polypeptide binding]; other site 1052588000346 zinc binding site [ion binding]; other site 1052588000347 CDP-binding sites; other site 1052588000348 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1052588000349 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1052588000350 active site 1052588000351 HIGH motif; other site 1052588000352 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1052588000353 active site 1052588000354 KMSKS motif; other site 1052588000355 serine O-acetyltransferase; Region: cysE; TIGR01172 1052588000356 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1052588000357 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1052588000358 trimer interface [polypeptide binding]; other site 1052588000359 active site 1052588000360 substrate binding site [chemical binding]; other site 1052588000361 CoA binding site [chemical binding]; other site 1052588000362 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1052588000363 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1052588000364 active site 1052588000365 HIGH motif; other site 1052588000366 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1052588000367 KMSKS motif; other site 1052588000368 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1052588000369 tRNA binding surface [nucleotide binding]; other site 1052588000370 anticodon binding site; other site 1052588000371 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1052588000372 active site 1052588000373 metal binding site [ion binding]; metal-binding site 1052588000374 dimerization interface [polypeptide binding]; other site 1052588000375 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1052588000376 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1052588000377 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1052588000378 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1052588000379 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1052588000380 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588000381 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1052588000382 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1052588000383 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1052588000384 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1052588000385 putative homodimer interface [polypeptide binding]; other site 1052588000386 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1052588000387 heterodimer interface [polypeptide binding]; other site 1052588000388 homodimer interface [polypeptide binding]; other site 1052588000389 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1052588000390 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1052588000391 23S rRNA interface [nucleotide binding]; other site 1052588000392 L7/L12 interface [polypeptide binding]; other site 1052588000393 putative thiostrepton binding site; other site 1052588000394 L25 interface [polypeptide binding]; other site 1052588000395 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1052588000396 mRNA/rRNA interface [nucleotide binding]; other site 1052588000397 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1052588000398 23S rRNA interface [nucleotide binding]; other site 1052588000399 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1052588000400 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1052588000401 core dimer interface [polypeptide binding]; other site 1052588000402 peripheral dimer interface [polypeptide binding]; other site 1052588000403 L10 interface [polypeptide binding]; other site 1052588000404 L11 interface [polypeptide binding]; other site 1052588000405 putative EF-Tu interaction site [polypeptide binding]; other site 1052588000406 putative EF-G interaction site [polypeptide binding]; other site 1052588000407 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1052588000408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588000409 S-adenosylmethionine binding site [chemical binding]; other site 1052588000410 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1052588000411 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1052588000412 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1052588000413 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1052588000414 RPB1 interaction site [polypeptide binding]; other site 1052588000415 RPB10 interaction site [polypeptide binding]; other site 1052588000416 RPB11 interaction site [polypeptide binding]; other site 1052588000417 RPB3 interaction site [polypeptide binding]; other site 1052588000418 RPB12 interaction site [polypeptide binding]; other site 1052588000419 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1052588000420 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1052588000421 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1052588000422 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1052588000423 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1052588000424 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1052588000425 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1052588000426 G-loop; other site 1052588000427 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1052588000428 DNA binding site [nucleotide binding] 1052588000429 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1052588000430 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1052588000431 30S ribosomal protein S7; Validated; Region: PRK05302 1052588000432 elongation factor G; Reviewed; Region: PRK00007 1052588000433 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1052588000434 Switch I region; other site 1052588000435 G2 box; other site 1052588000436 putative GEF interaction site [polypeptide binding]; other site 1052588000437 G3 box; other site 1052588000438 Switch II region; other site 1052588000439 GTP/Mg2+ binding site [chemical binding]; other site 1052588000440 G4 box; other site 1052588000441 G5 box; other site 1052588000442 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1052588000443 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1052588000444 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1052588000445 elongation factor Tu; Reviewed; Region: PRK00049 1052588000446 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1052588000447 G1 box; other site 1052588000448 GEF interaction site [polypeptide binding]; other site 1052588000449 GTP/Mg2+ binding site [chemical binding]; other site 1052588000450 Switch I region; other site 1052588000451 G2 box; other site 1052588000452 G3 box; other site 1052588000453 Switch II region; other site 1052588000454 G4 box; other site 1052588000455 G5 box; other site 1052588000456 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1052588000457 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1052588000458 Antibiotic Binding Site [chemical binding]; other site 1052588000459 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052588000460 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1052588000461 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1052588000462 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1052588000463 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1052588000464 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1052588000465 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1052588000466 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1052588000467 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1052588000468 putative translocon binding site; other site 1052588000469 protein-rRNA interface [nucleotide binding]; other site 1052588000470 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1052588000471 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1052588000472 G-X-X-G motif; other site 1052588000473 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1052588000474 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1052588000475 23S rRNA interface [nucleotide binding]; other site 1052588000476 5S rRNA interface [nucleotide binding]; other site 1052588000477 putative antibiotic binding site [chemical binding]; other site 1052588000478 L25 interface [polypeptide binding]; other site 1052588000479 L27 interface [polypeptide binding]; other site 1052588000480 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1052588000481 23S rRNA interface [nucleotide binding]; other site 1052588000482 putative translocon interaction site; other site 1052588000483 signal recognition particle (SRP54) interaction site; other site 1052588000484 L23 interface [polypeptide binding]; other site 1052588000485 trigger factor interaction site; other site 1052588000486 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1052588000487 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1052588000488 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1052588000489 RNA binding site [nucleotide binding]; other site 1052588000490 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1052588000491 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1052588000492 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1052588000493 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1052588000494 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1052588000495 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1052588000496 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1052588000497 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1052588000498 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1052588000499 5S rRNA interface [nucleotide binding]; other site 1052588000500 L27 interface [polypeptide binding]; other site 1052588000501 23S rRNA interface [nucleotide binding]; other site 1052588000502 L5 interface [polypeptide binding]; other site 1052588000503 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1052588000504 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1052588000505 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1052588000506 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1052588000507 23S rRNA binding site [nucleotide binding]; other site 1052588000508 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1052588000509 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1052588000510 SecY translocase; Region: SecY; pfam00344 1052588000511 adenylate kinase; Reviewed; Region: adk; PRK00279 1052588000512 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1052588000513 AMP-binding site [chemical binding]; other site 1052588000514 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1052588000515 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1052588000516 active site 1052588000517 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 1052588000518 RNA binding site [nucleotide binding]; other site 1052588000519 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1052588000520 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1052588000521 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1052588000522 30S ribosomal protein S11; Validated; Region: PRK05309 1052588000523 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1052588000524 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1052588000525 alphaNTD homodimer interface [polypeptide binding]; other site 1052588000526 alphaNTD - beta interaction site [polypeptide binding]; other site 1052588000527 alphaNTD - beta' interaction site [polypeptide binding]; other site 1052588000528 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1052588000529 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1052588000530 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1052588000531 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052588000532 Walker A/P-loop; other site 1052588000533 ATP binding site [chemical binding]; other site 1052588000534 Q-loop/lid; other site 1052588000535 ABC transporter signature motif; other site 1052588000536 Walker B; other site 1052588000537 D-loop; other site 1052588000538 H-loop/switch region; other site 1052588000539 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1052588000540 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052588000541 Walker A/P-loop; other site 1052588000542 ATP binding site [chemical binding]; other site 1052588000543 Q-loop/lid; other site 1052588000544 ABC transporter signature motif; other site 1052588000545 Walker B; other site 1052588000546 D-loop; other site 1052588000547 H-loop/switch region; other site 1052588000548 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1052588000549 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1052588000550 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1052588000551 dimerization interface 3.5A [polypeptide binding]; other site 1052588000552 active site 1052588000553 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1052588000554 23S rRNA interface [nucleotide binding]; other site 1052588000555 L3 interface [polypeptide binding]; other site 1052588000556 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1052588000557 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052588000558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588000559 S-adenosylmethionine binding site [chemical binding]; other site 1052588000560 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1052588000561 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1052588000562 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052588000563 active site 1052588000564 metal binding site [ion binding]; metal-binding site 1052588000565 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1052588000566 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1052588000567 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1052588000568 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052588000569 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 1052588000570 NodB motif; other site 1052588000571 putative active site [active] 1052588000572 putative catalytic site [active] 1052588000573 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1052588000574 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1052588000575 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1052588000576 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1052588000577 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1052588000578 Sodium Bile acid symporter family; Region: SBF; cl17470 1052588000579 Sodium Bile acid symporter family; Region: SBF; cl17470 1052588000580 Putative esterase; Region: Esterase; pfam00756 1052588000581 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1052588000582 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052588000583 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588000584 dimer interface [polypeptide binding]; other site 1052588000585 putative PBP binding regions; other site 1052588000586 ABC-ATPase subunit interface; other site 1052588000587 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052588000588 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588000589 ABC-ATPase subunit interface; other site 1052588000590 dimer interface [polypeptide binding]; other site 1052588000591 putative PBP binding regions; other site 1052588000592 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052588000593 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052588000594 putative ligand binding residues [chemical binding]; other site 1052588000595 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588000596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588000597 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052588000598 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052588000599 putative ligand binding residues [chemical binding]; other site 1052588000600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 1052588000601 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1052588000602 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1052588000603 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1052588000604 putative periplasmic esterase; Provisional; Region: PRK03642 1052588000605 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052588000606 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1052588000607 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588000608 active site turn [active] 1052588000609 phosphorylation site [posttranslational modification] 1052588000610 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052588000611 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1052588000612 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052588000613 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1052588000614 putative active site [active] 1052588000615 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 1052588000616 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1052588000617 putative active site [active] 1052588000618 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1052588000619 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1052588000620 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1052588000621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588000622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588000623 DNA binding residues [nucleotide binding] 1052588000624 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1052588000625 Putative zinc-finger; Region: zf-HC2; pfam13490 1052588000626 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1052588000627 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1052588000628 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052588000629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1052588000630 YbbR-like protein; Region: YbbR; pfam07949 1052588000631 YbbR-like protein; Region: YbbR; pfam07949 1052588000632 YbbR-like protein; Region: YbbR; pfam07949 1052588000633 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1052588000634 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1052588000635 active site 1052588000636 substrate binding site [chemical binding]; other site 1052588000637 metal binding site [ion binding]; metal-binding site 1052588000638 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1052588000639 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1052588000640 glutaminase active site [active] 1052588000641 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1052588000642 dimer interface [polypeptide binding]; other site 1052588000643 active site 1052588000644 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1052588000645 dimer interface [polypeptide binding]; other site 1052588000646 active site 1052588000647 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1052588000648 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1052588000649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1052588000650 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1052588000651 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1052588000652 zinc binding site [ion binding]; other site 1052588000653 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1052588000654 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588000655 dimerization interface [polypeptide binding]; other site 1052588000656 putative DNA binding site [nucleotide binding]; other site 1052588000657 putative Zn2+ binding site [ion binding]; other site 1052588000658 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588000659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000660 putative substrate translocation pore; other site 1052588000661 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1052588000662 active site 1052588000663 ATP binding site [chemical binding]; other site 1052588000664 substrate binding site [chemical binding]; other site 1052588000665 activation loop (A-loop); other site 1052588000666 putative transport protein YifK; Provisional; Region: PRK10746 1052588000667 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1052588000668 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052588000669 Cytochrome P450; Region: p450; cl12078 1052588000670 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1052588000671 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052588000672 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588000673 active site 1052588000674 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1052588000675 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1052588000676 active site 1052588000677 catalytic site [active] 1052588000678 metal binding site [ion binding]; metal-binding site 1052588000679 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1052588000680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000681 putative substrate translocation pore; other site 1052588000682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000683 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1052588000684 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588000685 MarR family; Region: MarR; pfam01047 1052588000686 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1052588000687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588000688 Coenzyme A binding pocket [chemical binding]; other site 1052588000689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000690 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588000691 putative substrate translocation pore; other site 1052588000692 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052588000693 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052588000694 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052588000695 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052588000696 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1052588000697 active site 1052588000698 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052588000699 EamA-like transporter family; Region: EamA; pfam00892 1052588000700 EamA-like transporter family; Region: EamA; pfam00892 1052588000701 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052588000702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588000703 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588000704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588000705 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1052588000706 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588000707 ATP-grasp domain; Region: ATP-grasp; pfam02222 1052588000708 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1052588000709 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1052588000710 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052588000711 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1052588000712 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1052588000713 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1052588000714 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052588000715 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1052588000716 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1052588000717 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1052588000718 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1052588000719 active site residue [active] 1052588000720 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1052588000721 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052588000722 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052588000723 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052588000724 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1052588000725 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588000726 active site turn [active] 1052588000727 phosphorylation site [posttranslational modification] 1052588000728 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1052588000729 HPr interaction site; other site 1052588000730 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052588000731 active site 1052588000732 phosphorylation site [posttranslational modification] 1052588000733 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1052588000734 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1052588000735 active site 1052588000736 trimer interface [polypeptide binding]; other site 1052588000737 allosteric site; other site 1052588000738 active site lid [active] 1052588000739 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052588000740 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052588000741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588000742 DNA-binding site [nucleotide binding]; DNA binding site 1052588000743 UTRA domain; Region: UTRA; pfam07702 1052588000744 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1052588000745 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1052588000746 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1052588000747 homodimer interface [polypeptide binding]; other site 1052588000748 substrate-cofactor binding pocket; other site 1052588000749 catalytic residue [active] 1052588000750 S-methylmethionine transporter; Provisional; Region: PRK11387 1052588000751 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1052588000752 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1052588000753 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052588000754 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1052588000755 glutaminase; Reviewed; Region: PRK12357 1052588000756 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1052588000757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588000758 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588000759 active site 1052588000760 phosphorylation site [posttranslational modification] 1052588000761 intermolecular recognition site; other site 1052588000762 dimerization interface [polypeptide binding]; other site 1052588000763 YcbB domain; Region: YcbB; pfam08664 1052588000764 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1052588000765 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1052588000766 putative active site [active] 1052588000767 catalytic residue [active] 1052588000768 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1052588000769 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052588000770 NAD(P) binding site [chemical binding]; other site 1052588000771 catalytic residues [active] 1052588000772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000773 D-galactonate transporter; Region: 2A0114; TIGR00893 1052588000774 putative substrate translocation pore; other site 1052588000775 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1052588000776 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1052588000777 active site 1052588000778 tetramer interface [polypeptide binding]; other site 1052588000779 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1052588000780 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588000781 DNA-binding site [nucleotide binding]; DNA binding site 1052588000782 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1052588000783 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1052588000784 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1052588000785 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1052588000786 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1052588000787 putative active site [active] 1052588000788 putative substrate binding site [chemical binding]; other site 1052588000789 Phosphotransferase enzyme family; Region: APH; pfam01636 1052588000790 ATP binding site [chemical binding]; other site 1052588000791 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1052588000792 dodecamer interface 1 [polypeptide binding]; other site 1052588000793 dodecamer interface 2 [polypeptide binding]; other site 1052588000794 trimer interface [polypeptide binding]; other site 1052588000795 TRAP binding interface [polypeptide binding]; other site 1052588000796 Zn binding site [ion binding]; other site 1052588000797 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052588000798 EamA-like transporter family; Region: EamA; pfam00892 1052588000799 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588000800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588000801 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1052588000802 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1052588000803 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052588000804 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1052588000805 metal ion-dependent adhesion site (MIDAS); other site 1052588000806 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1052588000807 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1052588000808 putative active site [active] 1052588000809 putative metal binding site [ion binding]; other site 1052588000810 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1052588000811 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1052588000812 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1052588000813 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1052588000814 putative substrate binding pocket [chemical binding]; other site 1052588000815 AC domain interface; other site 1052588000816 catalytic triad [active] 1052588000817 AB domain interface; other site 1052588000818 interchain disulfide; other site 1052588000819 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1052588000820 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052588000821 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588000822 catalytic residue [active] 1052588000823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000824 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588000825 putative substrate translocation pore; other site 1052588000826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588000828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588000829 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1052588000830 active site 1052588000831 homotetramer interface [polypeptide binding]; other site 1052588000832 homodimer interface [polypeptide binding]; other site 1052588000833 Lipase (class 2); Region: Lipase_2; pfam01674 1052588000834 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588000835 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1052588000836 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1052588000837 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1052588000838 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052588000839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588000840 ATP binding site [chemical binding]; other site 1052588000841 Mg2+ binding site [ion binding]; other site 1052588000842 G-X-G motif; other site 1052588000843 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1052588000844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588000845 active site 1052588000846 phosphorylation site [posttranslational modification] 1052588000847 intermolecular recognition site; other site 1052588000848 dimerization interface [polypeptide binding]; other site 1052588000849 LytTr DNA-binding domain; Region: LytTR; pfam04397 1052588000850 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052588000851 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 1052588000852 Walker A/P-loop; other site 1052588000853 ATP binding site [chemical binding]; other site 1052588000854 Q-loop/lid; other site 1052588000855 ABC transporter signature motif; other site 1052588000856 Walker B; other site 1052588000857 D-loop; other site 1052588000858 H-loop/switch region; other site 1052588000859 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052588000860 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1052588000861 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588000862 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052588000863 active site 1052588000864 catalytic tetrad [active] 1052588000865 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052588000866 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052588000867 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1052588000868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052588000869 binding surface 1052588000870 TPR motif; other site 1052588000871 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588000872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588000873 binding surface 1052588000874 TPR motif; other site 1052588000875 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1052588000876 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1052588000877 NAD binding site [chemical binding]; other site 1052588000878 homodimer interface [polypeptide binding]; other site 1052588000879 active site 1052588000880 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052588000881 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052588000882 Ca binding site [ion binding]; other site 1052588000883 active site 1052588000884 catalytic site [active] 1052588000885 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1052588000886 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1052588000887 metal binding site [ion binding]; metal-binding site 1052588000888 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052588000889 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1052588000890 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1052588000891 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588000892 ABC-ATPase subunit interface; other site 1052588000893 dimer interface [polypeptide binding]; other site 1052588000894 putative PBP binding regions; other site 1052588000895 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1052588000896 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052588000897 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1052588000898 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052588000899 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052588000900 putative metal binding site [ion binding]; other site 1052588000901 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052588000902 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052588000903 putative metal binding site [ion binding]; other site 1052588000904 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052588000905 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052588000906 putative metal binding site [ion binding]; other site 1052588000907 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1052588000908 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1052588000909 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 1052588000910 benzoate transport; Region: 2A0115; TIGR00895 1052588000911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000912 putative substrate translocation pore; other site 1052588000913 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588000914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000915 putative substrate translocation pore; other site 1052588000916 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588000917 dimerization interface [polypeptide binding]; other site 1052588000918 putative DNA binding site [nucleotide binding]; other site 1052588000919 putative Zn2+ binding site [ion binding]; other site 1052588000920 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1052588000921 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1052588000922 Walker A/P-loop; other site 1052588000923 ATP binding site [chemical binding]; other site 1052588000924 Q-loop/lid; other site 1052588000925 ABC transporter signature motif; other site 1052588000926 Walker B; other site 1052588000927 D-loop; other site 1052588000928 H-loop/switch region; other site 1052588000929 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1052588000930 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1052588000931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588000932 dimer interface [polypeptide binding]; other site 1052588000933 conserved gate region; other site 1052588000934 putative PBP binding loops; other site 1052588000935 ABC-ATPase subunit interface; other site 1052588000936 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1052588000937 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1052588000938 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1052588000939 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1052588000940 amidohydrolase; Region: amidohydrolases; TIGR01891 1052588000941 metal binding site [ion binding]; metal-binding site 1052588000942 putative dimer interface [polypeptide binding]; other site 1052588000943 Predicted membrane protein [Function unknown]; Region: COG1288 1052588000944 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1052588000945 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1052588000946 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1052588000947 active site 1052588000948 Ca binding site [ion binding]; other site 1052588000949 catalytic site [active] 1052588000950 Aamy_C domain; Region: Aamy_C; smart00632 1052588000951 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1052588000952 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1052588000953 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588000954 NAD binding site [chemical binding]; other site 1052588000955 dimer interface [polypeptide binding]; other site 1052588000956 substrate binding site [chemical binding]; other site 1052588000957 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1052588000958 L-lactate permease; Region: Lactate_perm; pfam02652 1052588000959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000960 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588000961 putative substrate translocation pore; other site 1052588000962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000963 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588000964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588000965 putative DNA binding site [nucleotide binding]; other site 1052588000966 putative Zn2+ binding site [ion binding]; other site 1052588000967 LysE type translocator; Region: LysE; pfam01810 1052588000968 Uncharacterized conserved protein [Function unknown]; Region: COG3403 1052588000969 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052588000970 Spore germination protein; Region: Spore_permease; cl17796 1052588000971 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1052588000972 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1052588000973 NAD+ synthetase; Region: nadE; TIGR00552 1052588000974 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1052588000975 homodimer interface [polypeptide binding]; other site 1052588000976 NAD binding pocket [chemical binding]; other site 1052588000977 ATP binding pocket [chemical binding]; other site 1052588000978 Mg binding site [ion binding]; other site 1052588000979 active-site loop [active] 1052588000980 AAA domain; Region: AAA_33; pfam13671 1052588000981 AAA domain; Region: AAA_17; cl17253 1052588000982 shikimate kinase; Reviewed; Region: aroK; PRK00131 1052588000983 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1052588000984 ADP binding site [chemical binding]; other site 1052588000985 magnesium binding site [ion binding]; other site 1052588000986 putative shikimate binding site; other site 1052588000987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588000988 S-adenosylmethionine binding site [chemical binding]; other site 1052588000989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588000990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588000991 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588000992 dimerization interface [polypeptide binding]; other site 1052588000993 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1052588000994 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1052588000995 Proline dehydrogenase; Region: Pro_dh; pfam01619 1052588000996 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1052588000997 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1052588000998 Glutamate binding site [chemical binding]; other site 1052588000999 homodimer interface [polypeptide binding]; other site 1052588001000 NAD binding site [chemical binding]; other site 1052588001001 catalytic residues [active] 1052588001002 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1052588001003 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1052588001004 Na binding site [ion binding]; other site 1052588001005 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052588001006 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1052588001007 Predicted membrane protein [Function unknown]; Region: COG3689 1052588001008 Predicted permeases [General function prediction only]; Region: COG0701 1052588001009 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052588001010 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1052588001011 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052588001012 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588001013 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1052588001014 active site 1052588001015 SAM binding site [chemical binding]; other site 1052588001016 homodimer interface [polypeptide binding]; other site 1052588001017 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1052588001018 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052588001019 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1052588001020 [2Fe-2S] cluster binding site [ion binding]; other site 1052588001021 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1052588001022 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588001023 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1052588001024 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1052588001025 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052588001026 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1052588001027 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1052588001028 [4Fe-4S] binding site [ion binding]; other site 1052588001029 molybdopterin cofactor binding site; other site 1052588001030 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1052588001031 molybdopterin cofactor binding site; other site 1052588001032 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1052588001033 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588001034 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1052588001035 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1052588001036 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052588001037 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1052588001038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001039 putative substrate translocation pore; other site 1052588001040 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 1052588001041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1052588001042 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1052588001043 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1052588001044 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1052588001045 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1052588001046 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052588001047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588001048 dimer interface [polypeptide binding]; other site 1052588001049 conserved gate region; other site 1052588001050 putative PBP binding loops; other site 1052588001051 ABC-ATPase subunit interface; other site 1052588001052 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052588001053 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052588001054 substrate binding pocket [chemical binding]; other site 1052588001055 membrane-bound complex binding site; other site 1052588001056 hinge residues; other site 1052588001057 RDD family; Region: RDD; pfam06271 1052588001058 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1052588001059 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588001060 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588001061 putative DNA binding site [nucleotide binding]; other site 1052588001062 putative Zn2+ binding site [ion binding]; other site 1052588001063 hypothetical protein; Provisional; Region: PRK09272 1052588001064 Predicted ATPase [General function prediction only]; Region: COG3910 1052588001065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588001066 Walker A/P-loop; other site 1052588001067 ATP binding site [chemical binding]; other site 1052588001068 Q-loop/lid; other site 1052588001069 ABC transporter signature motif; other site 1052588001070 Walker B; other site 1052588001071 D-loop; other site 1052588001072 H-loop/switch region; other site 1052588001073 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1052588001074 beta-galactosidase; Region: BGL; TIGR03356 1052588001075 Competence protein J (ComJ); Region: ComJ; pfam11033 1052588001076 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1052588001077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588001078 dimerization interface [polypeptide binding]; other site 1052588001079 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588001080 dimer interface [polypeptide binding]; other site 1052588001081 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1052588001082 putative CheW interface [polypeptide binding]; other site 1052588001083 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052588001084 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1052588001085 tetramer interface [polypeptide binding]; other site 1052588001086 active site 1052588001087 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1052588001088 active site 1052588001089 dimer interface [polypeptide binding]; other site 1052588001090 magnesium binding site [ion binding]; other site 1052588001091 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052588001092 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052588001093 Condensation domain; Region: Condensation; pfam00668 1052588001094 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588001095 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052588001096 acyl-activating enzyme (AAE) consensus motif; other site 1052588001097 AMP binding site [chemical binding]; other site 1052588001098 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588001099 Condensation domain; Region: Condensation; pfam00668 1052588001100 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588001101 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588001102 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052588001103 acyl-activating enzyme (AAE) consensus motif; other site 1052588001104 AMP binding site [chemical binding]; other site 1052588001105 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588001106 Condensation domain; Region: Condensation; pfam00668 1052588001107 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588001108 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588001109 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052588001110 acyl-activating enzyme (AAE) consensus motif; other site 1052588001111 AMP binding site [chemical binding]; other site 1052588001112 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588001113 Condensation domain; Region: Condensation; pfam00668 1052588001114 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052588001115 Condensation domain; Region: Condensation; pfam00668 1052588001116 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588001117 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052588001118 acyl-activating enzyme (AAE) consensus motif; other site 1052588001119 AMP binding site [chemical binding]; other site 1052588001120 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588001121 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1052588001122 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1052588001123 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1052588001124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001125 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588001126 putative substrate translocation pore; other site 1052588001127 YcxB-like protein; Region: YcxB; pfam14317 1052588001128 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052588001129 EamA-like transporter family; Region: EamA; pfam00892 1052588001130 EamA-like transporter family; Region: EamA; pfam00892 1052588001131 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052588001132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001133 DNA-binding site [nucleotide binding]; DNA binding site 1052588001134 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588001135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588001136 homodimer interface [polypeptide binding]; other site 1052588001137 catalytic residue [active] 1052588001138 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1052588001139 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 1052588001140 Predicted membrane protein [Function unknown]; Region: COG2364 1052588001141 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588001142 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052588001143 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052588001144 Walker A/P-loop; other site 1052588001145 ATP binding site [chemical binding]; other site 1052588001146 Q-loop/lid; other site 1052588001147 ABC transporter signature motif; other site 1052588001148 Walker B; other site 1052588001149 D-loop; other site 1052588001150 H-loop/switch region; other site 1052588001151 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052588001152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588001153 dimer interface [polypeptide binding]; other site 1052588001154 conserved gate region; other site 1052588001155 putative PBP binding loops; other site 1052588001156 ABC-ATPase subunit interface; other site 1052588001157 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052588001158 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052588001159 substrate binding pocket [chemical binding]; other site 1052588001160 membrane-bound complex binding site; other site 1052588001161 hinge residues; other site 1052588001162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588001163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588001164 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588001165 dimerization interface [polypeptide binding]; other site 1052588001166 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 1052588001167 Flavoprotein; Region: Flavoprotein; pfam02441 1052588001168 UbiD family decarboxylase; Region: TIGR00148 1052588001169 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1052588001170 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052588001171 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1052588001172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001173 putative substrate translocation pore; other site 1052588001174 POT family; Region: PTR2; pfam00854 1052588001175 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1052588001176 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1052588001177 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052588001178 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052588001179 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052588001180 Spore germination protein; Region: Spore_permease; pfam03845 1052588001181 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588001182 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052588001183 Walker A/P-loop; other site 1052588001184 ATP binding site [chemical binding]; other site 1052588001185 Q-loop/lid; other site 1052588001186 ABC transporter signature motif; other site 1052588001187 Walker B; other site 1052588001188 D-loop; other site 1052588001189 H-loop/switch region; other site 1052588001190 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052588001191 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052588001192 FtsX-like permease family; Region: FtsX; pfam02687 1052588001193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588001194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588001195 active site 1052588001196 phosphorylation site [posttranslational modification] 1052588001197 intermolecular recognition site; other site 1052588001198 dimerization interface [polypeptide binding]; other site 1052588001199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588001200 DNA binding site [nucleotide binding] 1052588001201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052588001202 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588001203 dimerization interface [polypeptide binding]; other site 1052588001204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588001205 dimer interface [polypeptide binding]; other site 1052588001206 phosphorylation site [posttranslational modification] 1052588001207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588001208 ATP binding site [chemical binding]; other site 1052588001209 Mg2+ binding site [ion binding]; other site 1052588001210 G-X-G motif; other site 1052588001211 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588001212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588001213 TPR motif; other site 1052588001214 binding surface 1052588001215 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588001216 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1052588001217 aspartate kinase; Reviewed; Region: PRK09034 1052588001218 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1052588001219 putative catalytic residues [active] 1052588001220 putative nucleotide binding site [chemical binding]; other site 1052588001221 putative aspartate binding site [chemical binding]; other site 1052588001222 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1052588001223 allosteric regulatory residue; other site 1052588001224 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1052588001225 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052588001226 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588001227 ABC-ATPase subunit interface; other site 1052588001228 dimer interface [polypeptide binding]; other site 1052588001229 putative PBP binding regions; other site 1052588001230 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052588001231 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588001232 ABC-ATPase subunit interface; other site 1052588001233 dimer interface [polypeptide binding]; other site 1052588001234 putative PBP binding regions; other site 1052588001235 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1052588001236 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052588001237 Walker A/P-loop; other site 1052588001238 ATP binding site [chemical binding]; other site 1052588001239 Q-loop/lid; other site 1052588001240 ABC transporter signature motif; other site 1052588001241 Walker B; other site 1052588001242 D-loop; other site 1052588001243 H-loop/switch region; other site 1052588001244 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1052588001245 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1052588001246 putative ligand binding residues [chemical binding]; other site 1052588001247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001248 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588001249 putative substrate translocation pore; other site 1052588001250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588001252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588001253 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1052588001254 dimer interface [polypeptide binding]; other site 1052588001255 FMN binding site [chemical binding]; other site 1052588001256 NADPH bind site [chemical binding]; other site 1052588001257 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1052588001258 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588001259 dimerization interface [polypeptide binding]; other site 1052588001260 putative DNA binding site [nucleotide binding]; other site 1052588001261 putative Zn2+ binding site [ion binding]; other site 1052588001262 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052588001263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001264 DNA-binding site [nucleotide binding]; DNA binding site 1052588001265 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588001266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588001267 homodimer interface [polypeptide binding]; other site 1052588001268 catalytic residue [active] 1052588001269 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1052588001270 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588001271 inhibitor-cofactor binding pocket; inhibition site 1052588001272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588001273 catalytic residue [active] 1052588001274 succinic semialdehyde dehydrogenase; Region: PLN02278 1052588001275 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1052588001276 tetramerization interface [polypeptide binding]; other site 1052588001277 NAD(P) binding site [chemical binding]; other site 1052588001278 catalytic residues [active] 1052588001279 Sugar transport protein; Region: Sugar_transport; pfam06800 1052588001280 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1052588001281 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1052588001282 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1052588001283 NAD binding site [chemical binding]; other site 1052588001284 homodimer interface [polypeptide binding]; other site 1052588001285 active site 1052588001286 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1052588001287 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1052588001288 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1052588001289 YtkA-like; Region: YtkA; pfam13115 1052588001290 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052588001291 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1052588001292 NosL; Region: NosL; cl01769 1052588001293 Integrase core domain; Region: rve; pfam00665 1052588001294 Integrase core domain; Region: rve_2; pfam13333 1052588001295 HTH-like domain; Region: HTH_21; pfam13276 1052588001296 Integrase core domain; Region: rve; pfam00665 1052588001297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1052588001298 Transposase; Region: HTH_Tnp_1; cl17663 1052588001299 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1052588001300 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1052588001301 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1052588001302 active site 1052588001303 P-loop; other site 1052588001304 phosphorylation site [posttranslational modification] 1052588001305 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052588001306 active site 1052588001307 phosphorylation site [posttranslational modification] 1052588001308 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1052588001309 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1052588001310 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1052588001311 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1052588001312 tartrate dehydrogenase; Provisional; Region: PRK08194 1052588001313 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052588001314 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052588001315 Catalytic site [active] 1052588001316 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1052588001317 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1052588001318 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1052588001319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588001320 active site 1052588001321 motif I; other site 1052588001322 motif II; other site 1052588001323 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588001324 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1052588001325 putative active site [active] 1052588001326 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1052588001327 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1052588001328 hypothetical protein; Provisional; Region: PRK05463 1052588001329 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1052588001330 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1052588001331 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1052588001332 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1052588001333 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1052588001334 Bacterial transcriptional regulator; Region: IclR; pfam01614 1052588001335 Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755 1052588001336 active site 1052588001337 catalytic triad [active] 1052588001338 oxyanion hole [active] 1052588001339 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1052588001340 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1052588001341 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1052588001342 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052588001343 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588001344 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052588001345 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588001346 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052588001347 active site 1052588001348 catalytic tetrad [active] 1052588001349 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052588001350 HTH domain; Region: HTH_11; pfam08279 1052588001351 PRD domain; Region: PRD; pfam00874 1052588001352 PRD domain; Region: PRD; pfam00874 1052588001353 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052588001354 active site 1052588001355 P-loop; other site 1052588001356 phosphorylation site [posttranslational modification] 1052588001357 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1052588001358 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1052588001359 acyl-activating enzyme (AAE) consensus motif; other site 1052588001360 putative AMP binding site [chemical binding]; other site 1052588001361 putative active site [active] 1052588001362 putative CoA binding site [chemical binding]; other site 1052588001363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588001364 S-adenosylmethionine binding site [chemical binding]; other site 1052588001365 short chain dehydrogenase; Provisional; Region: PRK06701 1052588001366 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052588001367 NAD binding site [chemical binding]; other site 1052588001368 metal binding site [ion binding]; metal-binding site 1052588001369 active site 1052588001370 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1052588001371 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052588001372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052588001373 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1052588001374 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1052588001375 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1052588001376 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1052588001377 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052588001378 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1052588001379 putative DNA binding site [nucleotide binding]; other site 1052588001380 putative Zn2+ binding site [ion binding]; other site 1052588001381 AsnC family; Region: AsnC_trans_reg; pfam01037 1052588001382 DNA topoisomerase III; Provisional; Region: PRK07726 1052588001383 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1052588001384 active site 1052588001385 putative interdomain interaction site [polypeptide binding]; other site 1052588001386 putative metal-binding site [ion binding]; other site 1052588001387 putative nucleotide binding site [chemical binding]; other site 1052588001388 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1052588001389 domain I; other site 1052588001390 DNA binding groove [nucleotide binding] 1052588001391 phosphate binding site [ion binding]; other site 1052588001392 domain II; other site 1052588001393 domain III; other site 1052588001394 nucleotide binding site [chemical binding]; other site 1052588001395 catalytic site [active] 1052588001396 domain IV; other site 1052588001397 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1052588001398 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1052588001399 CCC1-related family of proteins; Region: CCC1_like; cl00278 1052588001400 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052588001401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052588001402 metal binding site [ion binding]; metal-binding site 1052588001403 active site 1052588001404 I-site; other site 1052588001405 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1052588001406 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1052588001407 NodB motif; other site 1052588001408 putative active site [active] 1052588001409 putative catalytic site [active] 1052588001410 putative Zn binding site [ion binding]; other site 1052588001411 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1052588001412 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1052588001413 DXD motif; other site 1052588001414 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1052588001415 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1052588001416 Amino acid permease; Region: AA_permease_2; pfam13520 1052588001417 pyruvate oxidase; Provisional; Region: PRK08611 1052588001418 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1052588001419 PYR/PP interface [polypeptide binding]; other site 1052588001420 tetramer interface [polypeptide binding]; other site 1052588001421 dimer interface [polypeptide binding]; other site 1052588001422 TPP binding site [chemical binding]; other site 1052588001423 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1052588001424 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1052588001425 TPP-binding site [chemical binding]; other site 1052588001426 manganese transport protein MntH; Reviewed; Region: PRK00701 1052588001427 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1052588001428 Predicted membrane protein [Function unknown]; Region: COG2261 1052588001429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1052588001430 EcsC protein family; Region: EcsC; pfam12787 1052588001431 General stress protein [General function prediction only]; Region: GsiB; COG3729 1052588001432 General stress protein [General function prediction only]; Region: GsiB; COG3729 1052588001433 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1052588001434 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052588001435 dimanganese center [ion binding]; other site 1052588001436 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1052588001437 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1052588001438 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052588001439 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588001440 putative active site [active] 1052588001441 heme pocket [chemical binding]; other site 1052588001442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588001443 ATP binding site [chemical binding]; other site 1052588001444 Mg2+ binding site [ion binding]; other site 1052588001445 G-X-G motif; other site 1052588001446 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052588001447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588001448 active site 1052588001449 phosphorylation site [posttranslational modification] 1052588001450 intermolecular recognition site; other site 1052588001451 dimerization interface [polypeptide binding]; other site 1052588001452 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1052588001453 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1052588001454 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052588001455 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1052588001456 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052588001457 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052588001458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588001459 Walker A/P-loop; other site 1052588001460 ATP binding site [chemical binding]; other site 1052588001461 Q-loop/lid; other site 1052588001462 ABC transporter signature motif; other site 1052588001463 Walker B; other site 1052588001464 D-loop; other site 1052588001465 H-loop/switch region; other site 1052588001466 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1052588001467 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052588001468 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052588001469 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1052588001470 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1052588001471 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1052588001472 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1052588001473 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052588001474 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1052588001475 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052588001476 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052588001477 catalytic residues [active] 1052588001478 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1052588001479 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1052588001480 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1052588001481 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052588001482 helicase 45; Provisional; Region: PTZ00424 1052588001483 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052588001484 ATP binding site [chemical binding]; other site 1052588001485 Mg++ binding site [ion binding]; other site 1052588001486 motif III; other site 1052588001487 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588001488 nucleotide binding region [chemical binding]; other site 1052588001489 ATP-binding site [chemical binding]; other site 1052588001490 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1052588001491 Predicted membrane protein [Function unknown]; Region: COG3428 1052588001492 Bacterial PH domain; Region: DUF304; pfam03703 1052588001493 Bacterial PH domain; Region: DUF304; pfam03703 1052588001494 Bacterial PH domain; Region: DUF304; pfam03703 1052588001495 Rhomboid family; Region: Rhomboid; pfam01694 1052588001496 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1052588001497 alanine racemase; Region: alr; TIGR00492 1052588001498 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1052588001499 active site 1052588001500 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052588001501 dimer interface [polypeptide binding]; other site 1052588001502 substrate binding site [chemical binding]; other site 1052588001503 catalytic residues [active] 1052588001504 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1052588001505 ribbon-helix-helix domain containing protein; Region: PHA00617 1052588001506 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1052588001507 Rsbr N terminal; Region: Rsbr_N; pfam08678 1052588001508 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588001509 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588001510 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1052588001511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588001512 ATP binding site [chemical binding]; other site 1052588001513 Mg2+ binding site [ion binding]; other site 1052588001514 G-X-G motif; other site 1052588001515 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1052588001516 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1052588001517 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1052588001518 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1052588001519 anti sigma factor interaction site; other site 1052588001520 regulatory phosphorylation site [posttranslational modification]; other site 1052588001521 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1052588001522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588001523 ATP binding site [chemical binding]; other site 1052588001524 Mg2+ binding site [ion binding]; other site 1052588001525 G-X-G motif; other site 1052588001526 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1052588001527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588001528 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052588001529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588001530 DNA binding residues [nucleotide binding] 1052588001531 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1052588001532 hypothetical protein; Provisional; Region: PRK02268 1052588001533 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588001534 MarR family; Region: MarR; pfam01047 1052588001535 MarR family; Region: MarR_2; cl17246 1052588001536 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1052588001537 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1052588001538 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1052588001539 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1052588001540 RNA binding site [nucleotide binding]; other site 1052588001541 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1052588001542 hypothetical protein; Provisional; Region: PRK04351 1052588001543 potential frameshift: common BLAST hit: gi|350264743|ref|YP_004876050.1| luciferase family protein 1052588001544 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1052588001545 potential frameshift: common BLAST hit: gi|350264743|ref|YP_004876050.1| luciferase family protein 1052588001546 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1052588001547 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1052588001548 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1052588001549 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1052588001550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001551 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588001552 putative substrate translocation pore; other site 1052588001553 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1052588001554 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052588001555 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052588001556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588001557 non-specific DNA binding site [nucleotide binding]; other site 1052588001558 salt bridge; other site 1052588001559 sequence-specific DNA binding site [nucleotide binding]; other site 1052588001560 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1052588001561 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1052588001562 putative di-iron ligands [ion binding]; other site 1052588001563 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1052588001564 DNA-binding site [nucleotide binding]; DNA binding site 1052588001565 RNA-binding motif; other site 1052588001566 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1052588001567 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1052588001568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001569 DNA-binding site [nucleotide binding]; DNA binding site 1052588001570 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1052588001571 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1052588001572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001573 putative substrate translocation pore; other site 1052588001574 Cupin domain; Region: Cupin_2; pfam07883 1052588001575 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588001576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588001577 EamA-like transporter family; Region: EamA; pfam00892 1052588001578 EamA-like transporter family; Region: EamA; pfam00892 1052588001579 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588001580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588001581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1052588001582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001583 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588001584 putative substrate translocation pore; other site 1052588001585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1052588001586 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1052588001587 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1052588001588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1052588001589 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588001590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588001591 active site 1052588001592 phosphorylation site [posttranslational modification] 1052588001593 intermolecular recognition site; other site 1052588001594 dimerization interface [polypeptide binding]; other site 1052588001595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588001596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588001597 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1052588001598 putative dimerization interface [polypeptide binding]; other site 1052588001599 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1052588001600 Class II fumarases; Region: Fumarase_classII; cd01362 1052588001601 active site 1052588001602 tetramer interface [polypeptide binding]; other site 1052588001603 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1052588001604 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1052588001605 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052588001606 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1052588001607 putative DNA binding site [nucleotide binding]; other site 1052588001608 putative Zn2+ binding site [ion binding]; other site 1052588001609 AsnC family; Region: AsnC_trans_reg; pfam01037 1052588001610 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052588001611 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052588001612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001613 DNA-binding site [nucleotide binding]; DNA binding site 1052588001614 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588001615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588001616 homodimer interface [polypeptide binding]; other site 1052588001617 catalytic residue [active] 1052588001618 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1052588001619 putative active site [active] 1052588001620 putative catalytic site [active] 1052588001621 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1052588001622 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588001623 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052588001624 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052588001625 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052588001626 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588001627 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588001628 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052588001629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588001630 dimerization interface [polypeptide binding]; other site 1052588001631 putative DNA binding site [nucleotide binding]; other site 1052588001632 putative Zn2+ binding site [ion binding]; other site 1052588001633 arsenical pump membrane protein; Provisional; Region: PRK15445 1052588001634 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1052588001635 transmembrane helices; other site 1052588001636 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1052588001637 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052588001638 active site 1052588001639 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1052588001640 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052588001641 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1052588001642 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052588001643 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1052588001644 NodB motif; other site 1052588001645 active site 1052588001646 catalytic site [active] 1052588001647 Zn binding site [ion binding]; other site 1052588001648 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1052588001649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052588001650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588001651 dimerization interface [polypeptide binding]; other site 1052588001652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588001653 dimer interface [polypeptide binding]; other site 1052588001654 phosphorylation site [posttranslational modification] 1052588001655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588001656 ATP binding site [chemical binding]; other site 1052588001657 Mg2+ binding site [ion binding]; other site 1052588001658 G-X-G motif; other site 1052588001659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588001660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588001661 active site 1052588001662 phosphorylation site [posttranslational modification] 1052588001663 intermolecular recognition site; other site 1052588001664 dimerization interface [polypeptide binding]; other site 1052588001665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588001666 DNA binding site [nucleotide binding] 1052588001667 EamA-like transporter family; Region: EamA; pfam00892 1052588001668 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052588001669 EamA-like transporter family; Region: EamA; pfam00892 1052588001670 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052588001671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001672 DNA-binding site [nucleotide binding]; DNA binding site 1052588001673 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588001674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588001675 homodimer interface [polypeptide binding]; other site 1052588001676 catalytic residue [active] 1052588001677 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1052588001678 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588001679 putative DNA binding site [nucleotide binding]; other site 1052588001680 putative Zn2+ binding site [ion binding]; other site 1052588001681 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1052588001682 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1052588001683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588001684 Histidine kinase; Region: HisKA_3; pfam07730 1052588001685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588001686 ATP binding site [chemical binding]; other site 1052588001687 Mg2+ binding site [ion binding]; other site 1052588001688 G-X-G motif; other site 1052588001689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588001690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588001691 active site 1052588001692 phosphorylation site [posttranslational modification] 1052588001693 intermolecular recognition site; other site 1052588001694 dimerization interface [polypeptide binding]; other site 1052588001695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588001696 DNA binding residues [nucleotide binding] 1052588001697 dimerization interface [polypeptide binding]; other site 1052588001698 MMPL family; Region: MMPL; pfam03176 1052588001699 MMPL family; Region: MMPL; pfam03176 1052588001700 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1052588001701 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052588001702 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052588001703 DNA binding residues [nucleotide binding] 1052588001704 drug binding residues [chemical binding]; other site 1052588001705 dimer interface [polypeptide binding]; other site 1052588001706 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1052588001707 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052588001708 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1052588001709 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052588001710 dimer interface [polypeptide binding]; other site 1052588001711 FMN binding site [chemical binding]; other site 1052588001712 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052588001713 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588001714 Zn binding site [ion binding]; other site 1052588001715 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052588001716 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588001717 Zn binding site [ion binding]; other site 1052588001718 Predicted membrane protein [Function unknown]; Region: COG2259 1052588001719 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052588001720 catalytic residues [active] 1052588001721 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588001722 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588001723 Predicted membrane protein [Function unknown]; Region: COG2323 1052588001724 Predicted membrane protein [Function unknown]; Region: COG2323 1052588001725 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1052588001726 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1052588001727 putative dimer interface [polypeptide binding]; other site 1052588001728 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588001729 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588001730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588001731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588001732 DoxX-like family; Region: DoxX_2; pfam13564 1052588001733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588001734 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052588001735 Coenzyme A binding pocket [chemical binding]; other site 1052588001736 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1052588001737 nucleotide binding site/active site [active] 1052588001738 HIT family signature motif; other site 1052588001739 catalytic residue [active] 1052588001740 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588001741 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052588001742 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052588001743 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588001744 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588001745 DNA binding site [nucleotide binding] 1052588001746 domain linker motif; other site 1052588001747 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052588001748 dimerization interface [polypeptide binding]; other site 1052588001749 ligand binding site [chemical binding]; other site 1052588001750 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1052588001751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001752 putative substrate translocation pore; other site 1052588001753 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052588001754 UV-endonuclease UvdE; Region: UvdE; cl10036 1052588001755 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052588001756 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052588001757 ABC transporter; Region: ABC_tran_2; pfam12848 1052588001758 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052588001759 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052588001760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1052588001761 DinB superfamily; Region: DinB_2; pfam12867 1052588001762 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588001763 MarR family; Region: MarR; pfam01047 1052588001764 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1052588001765 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052588001766 dimer interface [polypeptide binding]; other site 1052588001767 FMN binding site [chemical binding]; other site 1052588001768 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588001769 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588001770 putative DNA binding site [nucleotide binding]; other site 1052588001771 putative Zn2+ binding site [ion binding]; other site 1052588001772 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1052588001773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001774 putative substrate translocation pore; other site 1052588001775 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1052588001776 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1052588001777 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001778 DNA-binding site [nucleotide binding]; DNA binding site 1052588001779 FCD domain; Region: FCD; pfam07729 1052588001780 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1052588001781 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588001782 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588001783 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1052588001784 active site 1052588001785 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1052588001786 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052588001787 homodimer interface [polypeptide binding]; other site 1052588001788 active site 1052588001789 TDP-binding site; other site 1052588001790 acceptor substrate-binding pocket; other site 1052588001791 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1052588001792 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052588001793 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1052588001794 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1052588001795 dimer interface [polypeptide binding]; other site 1052588001796 active site 1052588001797 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1052588001798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588001799 Coenzyme A binding pocket [chemical binding]; other site 1052588001800 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1052588001801 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052588001802 Zn2+ binding site [ion binding]; other site 1052588001803 Mg2+ binding site [ion binding]; other site 1052588001804 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1052588001805 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1052588001806 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588001807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001808 putative substrate translocation pore; other site 1052588001809 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1052588001810 active site 1052588001811 P-loop; other site 1052588001812 phosphorylation site [posttranslational modification] 1052588001813 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1052588001814 active site 1052588001815 methionine cluster; other site 1052588001816 phosphorylation site [posttranslational modification] 1052588001817 metal binding site [ion binding]; metal-binding site 1052588001818 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052588001819 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1052588001820 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1052588001821 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052588001822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001823 DNA-binding site [nucleotide binding]; DNA binding site 1052588001824 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1052588001825 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052588001826 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052588001827 nucleotide binding site [chemical binding]; other site 1052588001828 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1052588001829 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1052588001830 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1052588001831 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052588001832 dimanganese center [ion binding]; other site 1052588001833 thiamine-monophosphate kinase; Region: thiL; TIGR01379 1052588001834 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1052588001835 ATP binding site [chemical binding]; other site 1052588001836 dimerization interface [polypeptide binding]; other site 1052588001837 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1052588001838 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1052588001839 Glycoprotease family; Region: Peptidase_M22; pfam00814 1052588001840 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1052588001841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588001842 Coenzyme A binding pocket [chemical binding]; other site 1052588001843 UGMP family protein; Validated; Region: PRK09604 1052588001844 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052588001845 nucleotide binding site [chemical binding]; other site 1052588001846 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052588001847 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052588001848 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052588001849 ABC transporter; Region: ABC_tran_2; pfam12848 1052588001850 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052588001851 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1052588001852 trimer interface [polypeptide binding]; other site 1052588001853 dimer interface [polypeptide binding]; other site 1052588001854 putative active site [active] 1052588001855 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1052588001856 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1052588001857 CoA binding domain; Region: CoA_binding; pfam02629 1052588001858 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1052588001859 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1052588001860 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1052588001861 CAAX protease self-immunity; Region: Abi; pfam02517 1052588001862 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1052588001863 oligomerisation interface [polypeptide binding]; other site 1052588001864 mobile loop; other site 1052588001865 roof hairpin; other site 1052588001866 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1052588001867 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1052588001868 ring oligomerisation interface [polypeptide binding]; other site 1052588001869 ATP/Mg binding site [chemical binding]; other site 1052588001870 stacking interactions; other site 1052588001871 hinge regions; other site 1052588001872 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588001873 NB-ARC domain; Region: NB-ARC; pfam00931 1052588001874 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588001875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588001876 TPR motif; other site 1052588001877 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588001878 binding surface 1052588001879 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052588001880 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1052588001881 inhibitor binding site; inhibition site 1052588001882 catalytic Zn binding site [ion binding]; other site 1052588001883 structural Zn binding site [ion binding]; other site 1052588001884 NADP binding site [chemical binding]; other site 1052588001885 tetramer interface [polypeptide binding]; other site 1052588001886 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1052588001887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001888 putative substrate translocation pore; other site 1052588001889 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052588001890 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1052588001891 putative substrate binding site [chemical binding]; other site 1052588001892 putative ATP binding site [chemical binding]; other site 1052588001893 Ion channel; Region: Ion_trans_2; pfam07885 1052588001894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001895 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052588001896 putative substrate translocation pore; other site 1052588001897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001898 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052588001899 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1052588001900 putative NAD(P) binding site [chemical binding]; other site 1052588001901 catalytic Zn binding site [ion binding]; other site 1052588001902 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1052588001903 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1052588001904 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052588001905 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052588001906 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1052588001907 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1052588001908 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052588001909 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1052588001910 MoxR-like ATPases [General function prediction only]; Region: COG0714 1052588001911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588001912 Walker A motif; other site 1052588001913 ATP binding site [chemical binding]; other site 1052588001914 Walker B motif; other site 1052588001915 arginine finger; other site 1052588001916 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1052588001917 Protein of unknown function DUF58; Region: DUF58; pfam01882 1052588001918 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1052588001919 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1052588001920 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1052588001921 GMP synthase; Reviewed; Region: guaA; PRK00074 1052588001922 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1052588001923 AMP/PPi binding site [chemical binding]; other site 1052588001924 candidate oxyanion hole; other site 1052588001925 catalytic triad [active] 1052588001926 potential glutamine specificity residues [chemical binding]; other site 1052588001927 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1052588001928 ATP Binding subdomain [chemical binding]; other site 1052588001929 Ligand Binding sites [chemical binding]; other site 1052588001930 Dimerization subdomain; other site 1052588001931 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1052588001932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588001933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588001934 DNA binding residues [nucleotide binding] 1052588001935 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1052588001936 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1052588001937 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1052588001938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1052588001939 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052588001940 NETI protein; Region: NETI; pfam14044 1052588001941 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1052588001942 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1052588001943 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1052588001944 NAD binding site [chemical binding]; other site 1052588001945 ATP-grasp domain; Region: ATP-grasp; pfam02222 1052588001946 adenylosuccinate lyase; Provisional; Region: PRK07492 1052588001947 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1052588001948 tetramer interface [polypeptide binding]; other site 1052588001949 active site 1052588001950 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1052588001951 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1052588001952 ATP binding site [chemical binding]; other site 1052588001953 active site 1052588001954 substrate binding site [chemical binding]; other site 1052588001955 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1052588001956 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1052588001957 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1052588001958 putative active site [active] 1052588001959 catalytic triad [active] 1052588001960 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1052588001961 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1052588001962 dimerization interface [polypeptide binding]; other site 1052588001963 ATP binding site [chemical binding]; other site 1052588001964 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1052588001965 dimerization interface [polypeptide binding]; other site 1052588001966 ATP binding site [chemical binding]; other site 1052588001967 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1052588001968 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1052588001969 active site 1052588001970 tetramer interface [polypeptide binding]; other site 1052588001971 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588001972 active site 1052588001973 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1052588001974 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1052588001975 dimerization interface [polypeptide binding]; other site 1052588001976 putative ATP binding site [chemical binding]; other site 1052588001977 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1052588001978 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1052588001979 active site 1052588001980 substrate binding site [chemical binding]; other site 1052588001981 cosubstrate binding site; other site 1052588001982 catalytic site [active] 1052588001983 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1052588001984 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1052588001985 purine monophosphate binding site [chemical binding]; other site 1052588001986 dimer interface [polypeptide binding]; other site 1052588001987 putative catalytic residues [active] 1052588001988 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1052588001989 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1052588001990 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1052588001991 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1052588001992 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1052588001993 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1052588001994 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052588001995 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588001996 putative DNA binding site [nucleotide binding]; other site 1052588001997 putative Zn2+ binding site [ion binding]; other site 1052588001998 AsnC family; Region: AsnC_trans_reg; pfam01037 1052588001999 putative transporter; Provisional; Region: PRK11021 1052588002000 Spore germination protein; Region: Spore_permease; cl17796 1052588002001 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1052588002002 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1052588002003 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052588002004 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1052588002005 active site 1052588002006 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052588002007 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1052588002008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1052588002009 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1052588002010 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1052588002011 active site 1052588002012 FMN binding site [chemical binding]; other site 1052588002013 substrate binding site [chemical binding]; other site 1052588002014 3Fe-4S cluster binding site [ion binding]; other site 1052588002015 PcrB family; Region: PcrB; pfam01884 1052588002016 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1052588002017 substrate binding site [chemical binding]; other site 1052588002018 putative active site [active] 1052588002019 dimer interface [polypeptide binding]; other site 1052588002020 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1052588002021 Part of AAA domain; Region: AAA_19; pfam13245 1052588002022 Family description; Region: UvrD_C_2; pfam13538 1052588002023 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1052588002024 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1052588002025 nucleotide binding pocket [chemical binding]; other site 1052588002026 K-X-D-G motif; other site 1052588002027 catalytic site [active] 1052588002028 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1052588002029 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1052588002030 Helix-hairpin-helix motif; Region: HHH; pfam00633 1052588002031 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1052588002032 Dimer interface [polypeptide binding]; other site 1052588002033 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1052588002034 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1052588002035 putative dimer interface [polypeptide binding]; other site 1052588002036 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1052588002037 putative dimer interface [polypeptide binding]; other site 1052588002038 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1052588002039 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1052588002040 active site 1052588002041 ATP binding site [chemical binding]; other site 1052588002042 substrate binding site [chemical binding]; other site 1052588002043 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1052588002044 MgtC family; Region: MgtC; pfam02308 1052588002045 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1052588002046 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1052588002047 Na binding site [ion binding]; other site 1052588002048 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1052588002049 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1052588002050 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1052588002051 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1052588002052 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1052588002053 GatB domain; Region: GatB_Yqey; pfam02637 1052588002054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588002055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588002056 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1052588002057 Protein export membrane protein; Region: SecD_SecF; cl14618 1052588002058 Protein export membrane protein; Region: SecD_SecF; cl14618 1052588002059 putative lipid kinase; Reviewed; Region: PRK13337 1052588002060 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1052588002061 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1052588002062 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1052588002063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588002064 S-adenosylmethionine binding site [chemical binding]; other site 1052588002065 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1052588002066 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1052588002067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588002068 S-adenosylmethionine binding site [chemical binding]; other site 1052588002069 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1052588002070 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1052588002071 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1052588002072 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1052588002073 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1052588002074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588002075 ATP binding site [chemical binding]; other site 1052588002076 putative Mg++ binding site [ion binding]; other site 1052588002077 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1052588002078 Protein of unknown function, DUF600; Region: DUF600; cl04640 1052588002079 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1052588002080 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1052588002081 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1052588002082 hypothetical protein; Provisional; Region: PRK12378 1052588002083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588002084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588002085 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1052588002086 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1052588002087 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1052588002088 NADP binding site [chemical binding]; other site 1052588002089 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1052588002090 CotJB protein; Region: CotJB; pfam12652 1052588002091 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052588002092 dimanganese center [ion binding]; other site 1052588002093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588002094 Coenzyme A binding pocket [chemical binding]; other site 1052588002095 YesK-like protein; Region: YesK; pfam14150 1052588002096 Predicted integral membrane protein [Function unknown]; Region: COG5578 1052588002097 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052588002098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588002099 dimerization interface [polypeptide binding]; other site 1052588002100 Histidine kinase; Region: His_kinase; pfam06580 1052588002101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588002102 ATP binding site [chemical binding]; other site 1052588002103 Mg2+ binding site [ion binding]; other site 1052588002104 G-X-G motif; other site 1052588002105 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588002106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588002107 active site 1052588002108 phosphorylation site [posttranslational modification] 1052588002109 intermolecular recognition site; other site 1052588002110 dimerization interface [polypeptide binding]; other site 1052588002111 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588002112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588002113 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052588002114 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052588002115 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052588002116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588002117 dimer interface [polypeptide binding]; other site 1052588002118 conserved gate region; other site 1052588002119 putative PBP binding loops; other site 1052588002120 ABC-ATPase subunit interface; other site 1052588002121 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052588002122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588002123 dimer interface [polypeptide binding]; other site 1052588002124 conserved gate region; other site 1052588002125 putative PBP binding loops; other site 1052588002126 ABC-ATPase subunit interface; other site 1052588002127 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1052588002128 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588002129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588002130 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052588002131 active site 1052588002132 catalytic triad [active] 1052588002133 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 1052588002134 Predicted integral membrane protein [Function unknown]; Region: COG5578 1052588002135 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1052588002136 metal binding site [ion binding]; metal-binding site 1052588002137 active site 1052588002138 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1052588002139 metal binding site [ion binding]; metal-binding site 1052588002140 active site 1052588002141 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052588002142 active site 1052588002143 catalytic triad [active] 1052588002144 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1052588002145 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1052588002146 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1052588002147 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1052588002148 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052588002149 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052588002150 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052588002151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588002152 dimer interface [polypeptide binding]; other site 1052588002153 putative PBP binding loops; other site 1052588002154 ABC-ATPase subunit interface; other site 1052588002155 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052588002156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588002157 dimer interface [polypeptide binding]; other site 1052588002158 conserved gate region; other site 1052588002159 putative PBP binding loops; other site 1052588002160 ABC-ATPase subunit interface; other site 1052588002161 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1052588002162 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1052588002163 NAD binding site [chemical binding]; other site 1052588002164 sugar binding site [chemical binding]; other site 1052588002165 divalent metal binding site [ion binding]; other site 1052588002166 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588002167 dimer interface [polypeptide binding]; other site 1052588002168 Predicted membrane protein [Function unknown]; Region: COG2323 1052588002169 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1052588002170 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588002171 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1052588002172 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588002173 Uncharacterized small protein [Function unknown]; Region: COG5583 1052588002174 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1052588002175 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1052588002176 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588002177 MarR family; Region: MarR; pfam01047 1052588002178 hypothetical protein; Provisional; Region: PRK06847 1052588002179 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1052588002180 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1052588002181 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1052588002182 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052588002183 Cytochrome P450; Region: p450; pfam00067 1052588002184 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1052588002185 Flavodoxin; Region: Flavodoxin_1; pfam00258 1052588002186 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1052588002187 FAD binding pocket [chemical binding]; other site 1052588002188 FAD binding motif [chemical binding]; other site 1052588002189 catalytic residues [active] 1052588002190 NAD binding pocket [chemical binding]; other site 1052588002191 phosphate binding motif [ion binding]; other site 1052588002192 beta-alpha-beta structure motif; other site 1052588002193 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052588002194 Sulfatase; Region: Sulfatase; pfam00884 1052588002195 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1052588002196 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1052588002197 substrate binding site; other site 1052588002198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588002199 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052588002200 NAD(P) binding site [chemical binding]; other site 1052588002201 active site 1052588002202 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 1052588002203 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 1052588002204 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588002205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002206 putative substrate translocation pore; other site 1052588002207 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1052588002208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588002209 active site 1052588002210 motif I; other site 1052588002211 motif II; other site 1052588002212 amino acid transporter; Region: 2A0306; TIGR00909 1052588002213 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1052588002214 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1052588002215 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1052588002216 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588002217 dimer interface [polypeptide binding]; other site 1052588002218 putative CheW interface [polypeptide binding]; other site 1052588002219 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052588002220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588002221 Walker A/P-loop; other site 1052588002222 ATP binding site [chemical binding]; other site 1052588002223 Q-loop/lid; other site 1052588002224 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052588002225 ABC transporter signature motif; other site 1052588002226 Walker B; other site 1052588002227 D-loop; other site 1052588002228 ABC transporter; Region: ABC_tran_2; pfam12848 1052588002229 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052588002230 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1052588002231 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052588002232 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1052588002233 DNA binding residues [nucleotide binding] 1052588002234 putative dimer interface [polypeptide binding]; other site 1052588002235 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588002236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002237 putative substrate translocation pore; other site 1052588002238 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052588002239 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052588002240 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052588002241 ABC transporter; Region: ABC_tran_2; pfam12848 1052588002242 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052588002243 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1052588002244 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1052588002245 ATP binding site [chemical binding]; other site 1052588002246 putative Mg++ binding site [ion binding]; other site 1052588002247 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588002248 nucleotide binding region [chemical binding]; other site 1052588002249 ATP-binding site [chemical binding]; other site 1052588002250 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052588002251 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052588002252 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1052588002253 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1052588002254 NAD(P) binding site [chemical binding]; other site 1052588002255 substrate binding site [chemical binding]; other site 1052588002256 dimer interface [polypeptide binding]; other site 1052588002257 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052588002258 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052588002259 Walker A/P-loop; other site 1052588002260 ATP binding site [chemical binding]; other site 1052588002261 Q-loop/lid; other site 1052588002262 ABC transporter signature motif; other site 1052588002263 Walker B; other site 1052588002264 D-loop; other site 1052588002265 H-loop/switch region; other site 1052588002266 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052588002267 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588002268 ABC-ATPase subunit interface; other site 1052588002269 dimer interface [polypeptide binding]; other site 1052588002270 putative PBP binding regions; other site 1052588002271 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052588002272 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588002273 ABC-ATPase subunit interface; other site 1052588002274 dimer interface [polypeptide binding]; other site 1052588002275 putative PBP binding regions; other site 1052588002276 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1052588002277 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052588002278 siderophore binding site; other site 1052588002279 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1052588002280 Heat induced stress protein YflT; Region: YflT; pfam11181 1052588002281 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1052588002282 Amb_all domain; Region: Amb_all; smart00656 1052588002283 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1052588002284 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1052588002285 transmembrane helices; other site 1052588002286 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1052588002287 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1052588002288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588002289 S-adenosylmethionine binding site [chemical binding]; other site 1052588002290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1052588002291 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1052588002292 putative metal binding site; other site 1052588002293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588002294 binding surface 1052588002295 TPR motif; other site 1052588002296 TPR repeat; Region: TPR_11; pfam13414 1052588002297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588002298 binding surface 1052588002299 TPR motif; other site 1052588002300 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1052588002301 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1052588002302 Probable Catalytic site; other site 1052588002303 metal-binding site 1052588002304 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1052588002305 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052588002306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588002307 ATP binding site [chemical binding]; other site 1052588002308 Mg2+ binding site [ion binding]; other site 1052588002309 G-X-G motif; other site 1052588002310 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052588002311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588002312 active site 1052588002313 phosphorylation site [posttranslational modification] 1052588002314 intermolecular recognition site; other site 1052588002315 dimerization interface [polypeptide binding]; other site 1052588002316 Transcriptional regulator; Region: CitT; pfam12431 1052588002317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1052588002318 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1052588002319 Citrate transporter; Region: CitMHS; pfam03600 1052588002320 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052588002321 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1052588002322 active site 1052588002323 dimer interface [polypeptide binding]; other site 1052588002324 acylphosphatase; Provisional; Region: PRK14420 1052588002325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1052588002326 MOSC domain; Region: MOSC; pfam03473 1052588002327 3-alpha domain; Region: 3-alpha; pfam03475 1052588002328 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1052588002329 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1052588002330 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1052588002331 active site 1052588002332 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1052588002333 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052588002334 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588002335 active site turn [active] 1052588002336 phosphorylation site [posttranslational modification] 1052588002337 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052588002338 Sulfatase; Region: Sulfatase; pfam00884 1052588002339 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1052588002340 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052588002341 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1052588002342 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 1052588002343 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052588002344 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052588002345 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052588002346 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1052588002347 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588002348 active site turn [active] 1052588002349 phosphorylation site [posttranslational modification] 1052588002350 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052588002351 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052588002352 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052588002353 Ca binding site [ion binding]; other site 1052588002354 active site 1052588002355 catalytic site [active] 1052588002356 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1052588002357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588002358 DNA-binding site [nucleotide binding]; DNA binding site 1052588002359 UTRA domain; Region: UTRA; pfam07702 1052588002360 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1052588002361 dimer interface [polypeptide binding]; other site 1052588002362 FMN binding site [chemical binding]; other site 1052588002363 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1052588002364 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1052588002365 active site 1052588002366 metal binding site [ion binding]; metal-binding site 1052588002367 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052588002368 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 1052588002369 active site 1052588002370 metal binding site [ion binding]; metal-binding site 1052588002371 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052588002372 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1052588002373 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1052588002374 proposed catalytic triad [active] 1052588002375 conserved cys residue [active] 1052588002376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002377 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588002378 putative substrate translocation pore; other site 1052588002379 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1052588002380 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052588002381 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1052588002382 active site 1052588002383 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 1052588002384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002385 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588002386 putative substrate translocation pore; other site 1052588002387 calcium/proton exchanger (cax); Region: cax; TIGR00378 1052588002388 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1052588002389 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1052588002390 YfkD-like protein; Region: YfkD; pfam14167 1052588002391 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1052588002392 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1052588002393 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1052588002394 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588002395 FeS/SAM binding site; other site 1052588002396 YfkB-like domain; Region: YfkB; pfam08756 1052588002397 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1052588002398 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1052588002399 NodB motif; other site 1052588002400 active site 1052588002401 catalytic site [active] 1052588002402 Cd binding site [ion binding]; other site 1052588002403 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1052588002404 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1052588002405 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1052588002406 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1052588002407 oligomer interface [polypeptide binding]; other site 1052588002408 metal binding site [ion binding]; metal-binding site 1052588002409 metal binding site [ion binding]; metal-binding site 1052588002410 putative Cl binding site [ion binding]; other site 1052588002411 aspartate ring; other site 1052588002412 basic sphincter; other site 1052588002413 hydrophobic gate; other site 1052588002414 periplasmic entrance; other site 1052588002415 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1052588002416 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052588002417 minor groove reading motif; other site 1052588002418 helix-hairpin-helix signature motif; other site 1052588002419 substrate binding pocket [chemical binding]; other site 1052588002420 active site 1052588002421 TRAM domain; Region: TRAM; pfam01938 1052588002422 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1052588002423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588002424 S-adenosylmethionine binding site [chemical binding]; other site 1052588002425 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1052588002426 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1052588002427 FMN binding site [chemical binding]; other site 1052588002428 active site 1052588002429 catalytic residues [active] 1052588002430 substrate binding site [chemical binding]; other site 1052588002431 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1052588002432 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052588002433 tetramer interface [polypeptide binding]; other site 1052588002434 TPP-binding site [chemical binding]; other site 1052588002435 heterodimer interface [polypeptide binding]; other site 1052588002436 phosphorylation loop region [posttranslational modification] 1052588002437 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052588002438 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052588002439 alpha subunit interface [polypeptide binding]; other site 1052588002440 TPP binding site [chemical binding]; other site 1052588002441 heterodimer interface [polypeptide binding]; other site 1052588002442 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052588002443 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1052588002444 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052588002445 E3 interaction surface; other site 1052588002446 lipoyl attachment site [posttranslational modification]; other site 1052588002447 e3 binding domain; Region: E3_binding; pfam02817 1052588002448 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1052588002449 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1052588002450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588002451 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052588002452 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1052588002453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588002454 Walker A motif; other site 1052588002455 ATP binding site [chemical binding]; other site 1052588002456 Walker B motif; other site 1052588002457 arginine finger; other site 1052588002458 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1052588002459 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 1052588002460 hypothetical protein; Provisional; Region: PRK02237 1052588002461 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1052588002462 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 1052588002463 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052588002464 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1052588002465 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1052588002466 NAD binding site [chemical binding]; other site 1052588002467 sugar binding site [chemical binding]; other site 1052588002468 divalent metal binding site [ion binding]; other site 1052588002469 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588002470 dimer interface [polypeptide binding]; other site 1052588002471 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052588002472 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1052588002473 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1052588002474 putative active site [active] 1052588002475 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1052588002476 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1052588002477 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588002478 active site turn [active] 1052588002479 phosphorylation site [posttranslational modification] 1052588002480 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588002481 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052588002482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588002483 Walker A/P-loop; other site 1052588002484 ATP binding site [chemical binding]; other site 1052588002485 Q-loop/lid; other site 1052588002486 ABC transporter signature motif; other site 1052588002487 Walker B; other site 1052588002488 D-loop; other site 1052588002489 H-loop/switch region; other site 1052588002490 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588002491 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052588002492 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1052588002493 Walker A/P-loop; other site 1052588002494 ATP binding site [chemical binding]; other site 1052588002495 Q-loop/lid; other site 1052588002496 ABC transporter signature motif; other site 1052588002497 Walker B; other site 1052588002498 D-loop; other site 1052588002499 H-loop/switch region; other site 1052588002500 Predicted membrane protein [Function unknown]; Region: COG2259 1052588002501 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1052588002502 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1052588002503 putative metal binding site [ion binding]; other site 1052588002504 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1052588002505 active site 1052588002506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588002507 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588002508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588002509 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052588002510 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1052588002511 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588002512 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052588002513 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052588002514 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588002515 Histidine kinase; Region: HisKA_3; pfam07730 1052588002516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588002517 ATP binding site [chemical binding]; other site 1052588002518 Mg2+ binding site [ion binding]; other site 1052588002519 G-X-G motif; other site 1052588002520 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588002521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588002522 active site 1052588002523 phosphorylation site [posttranslational modification] 1052588002524 intermolecular recognition site; other site 1052588002525 dimerization interface [polypeptide binding]; other site 1052588002526 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588002527 DNA binding residues [nucleotide binding] 1052588002528 dimerization interface [polypeptide binding]; other site 1052588002529 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052588002530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588002531 Walker A/P-loop; other site 1052588002532 ATP binding site [chemical binding]; other site 1052588002533 Q-loop/lid; other site 1052588002534 ABC transporter signature motif; other site 1052588002535 Walker B; other site 1052588002536 D-loop; other site 1052588002537 H-loop/switch region; other site 1052588002538 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1052588002539 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1052588002540 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1052588002541 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1052588002542 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1052588002543 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052588002544 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052588002545 Predicted transcriptional regulators [Transcription]; Region: COG1695 1052588002546 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1052588002547 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1052588002548 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1052588002549 Lipase (class 2); Region: Lipase_2; pfam01674 1052588002550 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1052588002551 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052588002552 metal-dependent hydrolase; Provisional; Region: PRK13291 1052588002553 DinB superfamily; Region: DinB_2; pfam12867 1052588002554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002555 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588002556 putative substrate translocation pore; other site 1052588002557 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588002558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588002559 putative Zn2+ binding site [ion binding]; other site 1052588002560 putative DNA binding site [nucleotide binding]; other site 1052588002561 Predicted integral membrane protein [Function unknown]; Region: COG0392 1052588002562 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1052588002563 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1052588002564 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052588002565 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052588002566 siderophore binding site; other site 1052588002567 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052588002568 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588002569 ABC-ATPase subunit interface; other site 1052588002570 dimer interface [polypeptide binding]; other site 1052588002571 putative PBP binding regions; other site 1052588002572 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052588002573 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588002574 ABC-ATPase subunit interface; other site 1052588002575 dimer interface [polypeptide binding]; other site 1052588002576 putative PBP binding regions; other site 1052588002577 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1052588002578 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1052588002579 putative FMN binding site [chemical binding]; other site 1052588002580 YfhD-like protein; Region: YfhD; pfam14151 1052588002581 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1052588002582 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1052588002583 putative NAD(P) binding site [chemical binding]; other site 1052588002584 putative active site [active] 1052588002585 recombination regulator RecX; Provisional; Region: recX; PRK14135 1052588002586 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1052588002587 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588002588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002589 putative substrate translocation pore; other site 1052588002590 Small acid-soluble spore protein K family; Region: SspK; pfam08176 1052588002591 WVELL protein; Region: WVELL; pfam14043 1052588002592 Bacterial SH3 domain; Region: SH3_3; pfam08239 1052588002593 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1052588002594 Predicted integral membrane protein [Function unknown]; Region: COG5658 1052588002595 SdpI/YhfL protein family; Region: SdpI; pfam13630 1052588002596 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1052588002597 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052588002598 Ligand binding site; other site 1052588002599 Putative Catalytic site; other site 1052588002600 DXD motif; other site 1052588002601 Predicted membrane protein [Function unknown]; Region: COG4485 1052588002602 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1052588002603 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1052588002604 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052588002605 minor groove reading motif; other site 1052588002606 helix-hairpin-helix signature motif; other site 1052588002607 substrate binding pocket [chemical binding]; other site 1052588002608 active site 1052588002609 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1052588002610 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1052588002611 DNA binding and oxoG recognition site [nucleotide binding] 1052588002612 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1052588002613 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1052588002614 putative NAD(P) binding site [chemical binding]; other site 1052588002615 active site 1052588002616 YgaB-like protein; Region: YgaB; pfam14182 1052588002617 hypothetical protein; Provisional; Region: PRK13662 1052588002618 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588002619 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052588002620 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1052588002621 Walker A/P-loop; other site 1052588002622 ATP binding site [chemical binding]; other site 1052588002623 Q-loop/lid; other site 1052588002624 ABC transporter signature motif; other site 1052588002625 Walker B; other site 1052588002626 D-loop; other site 1052588002627 H-loop/switch region; other site 1052588002628 Predicted membrane protein [Function unknown]; Region: COG4129 1052588002629 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1052588002630 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1052588002631 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588002632 inhibitor-cofactor binding pocket; inhibition site 1052588002633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588002634 catalytic residue [active] 1052588002635 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1052588002636 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1052588002637 catalytic triad [active] 1052588002638 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052588002639 metal binding site 2 [ion binding]; metal-binding site 1052588002640 putative DNA binding helix; other site 1052588002641 metal binding site 1 [ion binding]; metal-binding site 1052588002642 dimer interface [polypeptide binding]; other site 1052588002643 structural Zn2+ binding site [ion binding]; other site 1052588002644 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1052588002645 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1052588002646 SpoOM protein; Region: Spo0M; pfam07070 1052588002647 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1052588002648 Coat F domain; Region: Coat_F; pfam07875 1052588002649 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1052588002650 active site pocket [active] 1052588002651 oxyanion hole [active] 1052588002652 catalytic triad [active] 1052588002653 active site nucleophile [active] 1052588002654 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1052588002655 ThiC-associated domain; Region: ThiC-associated; pfam13667 1052588002656 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1052588002657 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1052588002658 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1052588002659 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1052588002660 tetramer interface [polypeptide binding]; other site 1052588002661 heme binding pocket [chemical binding]; other site 1052588002662 NADPH binding site [chemical binding]; other site 1052588002663 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1052588002664 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1052588002665 Walker A/P-loop; other site 1052588002666 ATP binding site [chemical binding]; other site 1052588002667 Q-loop/lid; other site 1052588002668 ABC transporter signature motif; other site 1052588002669 Walker B; other site 1052588002670 D-loop; other site 1052588002671 H-loop/switch region; other site 1052588002672 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1052588002673 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052588002674 substrate binding pocket [chemical binding]; other site 1052588002675 membrane-bound complex binding site; other site 1052588002676 hinge residues; other site 1052588002677 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1052588002678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588002679 dimer interface [polypeptide binding]; other site 1052588002680 conserved gate region; other site 1052588002681 putative PBP binding loops; other site 1052588002682 ABC-ATPase subunit interface; other site 1052588002683 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1052588002684 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1052588002685 active site 1052588002686 dimer interface [polypeptide binding]; other site 1052588002687 non-prolyl cis peptide bond; other site 1052588002688 insertion regions; other site 1052588002689 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1052588002690 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052588002691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588002692 non-specific DNA binding site [nucleotide binding]; other site 1052588002693 salt bridge; other site 1052588002694 sequence-specific DNA binding site [nucleotide binding]; other site 1052588002695 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1052588002696 epoxyqueuosine reductase; Region: TIGR00276 1052588002697 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1052588002698 Putative amidase domain; Region: Amidase_6; pfam12671 1052588002699 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1052588002700 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1052588002701 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1052588002702 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1052588002703 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1052588002704 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1052588002705 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1052588002706 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1052588002707 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588002708 MarR family; Region: MarR; pfam01047 1052588002709 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1052588002710 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052588002711 carboxyltransferase (CT) interaction site; other site 1052588002712 biotinylation site [posttranslational modification]; other site 1052588002713 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052588002714 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1052588002715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002716 putative substrate translocation pore; other site 1052588002717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002718 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1052588002719 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052588002720 Predicted transcriptional regulators [Transcription]; Region: COG1725 1052588002721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588002722 DNA-binding site [nucleotide binding]; DNA binding site 1052588002723 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052588002724 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052588002725 Walker A/P-loop; other site 1052588002726 ATP binding site [chemical binding]; other site 1052588002727 Q-loop/lid; other site 1052588002728 ABC transporter signature motif; other site 1052588002729 Walker B; other site 1052588002730 D-loop; other site 1052588002731 H-loop/switch region; other site 1052588002732 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052588002733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588002734 Walker A/P-loop; other site 1052588002735 ATP binding site [chemical binding]; other site 1052588002736 Q-loop/lid; other site 1052588002737 ABC transporter signature motif; other site 1052588002738 Walker B; other site 1052588002739 D-loop; other site 1052588002740 H-loop/switch region; other site 1052588002741 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1052588002742 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052588002743 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1052588002744 DNA-binding site [nucleotide binding]; DNA binding site 1052588002745 RNA-binding motif; other site 1052588002746 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1052588002747 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1052588002748 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1052588002749 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052588002750 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052588002751 metal binding site [ion binding]; metal-binding site 1052588002752 active site 1052588002753 I-site; other site 1052588002754 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1052588002755 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052588002756 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1052588002757 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052588002758 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1052588002759 generic binding surface II; other site 1052588002760 generic binding surface I; other site 1052588002761 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1052588002762 generic binding surface II; other site 1052588002763 generic binding surface I; other site 1052588002764 Staphylococcal nuclease homologues; Region: SNc; smart00318 1052588002765 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1052588002766 Catalytic site; other site 1052588002767 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1052588002768 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1052588002769 putative active site [active] 1052588002770 putative metal binding site [ion binding]; other site 1052588002771 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052588002772 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1052588002773 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1052588002774 active site 1052588002775 catalytic site [active] 1052588002776 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1052588002777 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588002778 RNA binding surface [nucleotide binding]; other site 1052588002779 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052588002780 active site 1052588002781 FOG: CBS domain [General function prediction only]; Region: COG0517 1052588002782 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1052588002783 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1052588002784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588002785 motif II; other site 1052588002786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588002787 Coenzyme A binding pocket [chemical binding]; other site 1052588002788 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1052588002789 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1052588002790 putative active site [active] 1052588002791 catalytic triad [active] 1052588002792 putative dimer interface [polypeptide binding]; other site 1052588002793 aminotransferase; Validated; Region: PRK07678 1052588002794 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588002795 inhibitor-cofactor binding pocket; inhibition site 1052588002796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588002797 catalytic residue [active] 1052588002798 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1052588002799 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1052588002800 amphipathic channel; other site 1052588002801 Asn-Pro-Ala signature motifs; other site 1052588002802 glycerol kinase; Provisional; Region: glpK; PRK00047 1052588002803 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1052588002804 N- and C-terminal domain interface [polypeptide binding]; other site 1052588002805 active site 1052588002806 MgATP binding site [chemical binding]; other site 1052588002807 catalytic site [active] 1052588002808 metal binding site [ion binding]; metal-binding site 1052588002809 glycerol binding site [chemical binding]; other site 1052588002810 homotetramer interface [polypeptide binding]; other site 1052588002811 homodimer interface [polypeptide binding]; other site 1052588002812 FBP binding site [chemical binding]; other site 1052588002813 protein IIAGlc interface [polypeptide binding]; other site 1052588002814 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1052588002815 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1052588002816 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1052588002817 active site 1052588002818 substrate binding site [chemical binding]; other site 1052588002819 metal binding site [ion binding]; metal-binding site 1052588002820 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1052588002821 GAF domain; Region: GAF; pfam01590 1052588002822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588002823 Histidine kinase; Region: HisKA_3; pfam07730 1052588002824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588002825 ATP binding site [chemical binding]; other site 1052588002826 Mg2+ binding site [ion binding]; other site 1052588002827 G-X-G motif; other site 1052588002828 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588002829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588002830 active site 1052588002831 phosphorylation site [posttranslational modification] 1052588002832 intermolecular recognition site; other site 1052588002833 dimerization interface [polypeptide binding]; other site 1052588002834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588002835 DNA binding residues [nucleotide binding] 1052588002836 dimerization interface [polypeptide binding]; other site 1052588002837 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052588002838 Predicted flavoprotein [General function prediction only]; Region: COG0431 1052588002839 YhdB-like protein; Region: YhdB; pfam14148 1052588002840 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1052588002841 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002842 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002843 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002844 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002845 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002846 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052588002847 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052588002848 Transcriptional regulator; Region: Rrf2; cl17282 1052588002849 Rrf2 family protein; Region: rrf2_super; TIGR00738 1052588002850 Conserved TM helix; Region: TM_helix; pfam05552 1052588002851 Conserved TM helix; Region: TM_helix; pfam05552 1052588002852 Conserved TM helix; Region: TM_helix; pfam05552 1052588002853 Conserved TM helix; Region: TM_helix; pfam05552 1052588002854 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1052588002855 SpoVR like protein; Region: SpoVR; pfam04293 1052588002856 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1052588002857 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1052588002858 dimer interface [polypeptide binding]; other site 1052588002859 active site 1052588002860 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002861 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002862 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002863 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052588002864 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052588002865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588002866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588002867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588002868 dimerization interface [polypeptide binding]; other site 1052588002869 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1052588002870 dimer interface [polypeptide binding]; other site 1052588002871 Citrate synthase; Region: Citrate_synt; pfam00285 1052588002872 active site 1052588002873 citrylCoA binding site [chemical binding]; other site 1052588002874 oxalacetate/citrate binding site [chemical binding]; other site 1052588002875 coenzyme A binding site [chemical binding]; other site 1052588002876 catalytic triad [active] 1052588002877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588002878 NAD(P) binding site [chemical binding]; other site 1052588002879 active site 1052588002880 amino acid transporter; Region: 2A0306; TIGR00909 1052588002881 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1052588002882 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1052588002883 Na2 binding site [ion binding]; other site 1052588002884 putative substrate binding site 1 [chemical binding]; other site 1052588002885 Na binding site 1 [ion binding]; other site 1052588002886 putative substrate binding site 2 [chemical binding]; other site 1052588002887 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052588002888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588002889 DNA-binding site [nucleotide binding]; DNA binding site 1052588002890 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588002891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588002892 homodimer interface [polypeptide binding]; other site 1052588002893 catalytic residue [active] 1052588002894 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052588002895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588002896 Coenzyme A binding pocket [chemical binding]; other site 1052588002897 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1052588002898 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1052588002899 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1052588002900 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588002901 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588002902 DNA binding residues [nucleotide binding] 1052588002903 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588002904 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052588002905 active site 1052588002906 catalytic tetrad [active] 1052588002907 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1052588002908 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1052588002909 putative acyl-acceptor binding pocket; other site 1052588002910 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052588002911 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052588002912 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052588002913 Transporter associated domain; Region: CorC_HlyC; smart01091 1052588002914 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1052588002915 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052588002916 DNA binding residues [nucleotide binding] 1052588002917 putative dimer interface [polypeptide binding]; other site 1052588002918 aspartate aminotransferase; Provisional; Region: PRK06836 1052588002919 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588002920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588002921 homodimer interface [polypeptide binding]; other site 1052588002922 catalytic residue [active] 1052588002923 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052588002924 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052588002925 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052588002926 Transporter associated domain; Region: CorC_HlyC; smart01091 1052588002927 camphor resistance protein CrcB; Provisional; Region: PRK14213 1052588002928 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1052588002929 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1052588002930 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1052588002931 active site 1052588002932 catalytic site [active] 1052588002933 metal binding site [ion binding]; metal-binding site 1052588002934 dimer interface [polypeptide binding]; other site 1052588002935 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1052588002936 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1052588002937 NAD-dependent deacetylase; Provisional; Region: PRK00481 1052588002938 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1052588002939 NAD+ binding site [chemical binding]; other site 1052588002940 substrate binding site [chemical binding]; other site 1052588002941 Zn binding site [ion binding]; other site 1052588002942 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052588002943 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1052588002944 NodB motif; other site 1052588002945 active site 1052588002946 catalytic site [active] 1052588002947 Zn binding site [ion binding]; other site 1052588002948 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1052588002949 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1052588002950 homodimer interface [polypeptide binding]; other site 1052588002951 substrate-cofactor binding pocket; other site 1052588002952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588002953 catalytic residue [active] 1052588002954 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1052588002955 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1052588002956 Ligand Binding Site [chemical binding]; other site 1052588002957 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052588002958 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1052588002959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588002960 Walker A/P-loop; other site 1052588002961 ATP binding site [chemical binding]; other site 1052588002962 Q-loop/lid; other site 1052588002963 ABC transporter signature motif; other site 1052588002964 Walker B; other site 1052588002965 D-loop; other site 1052588002966 H-loop/switch region; other site 1052588002967 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588002968 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052588002969 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1052588002970 Walker A/P-loop; other site 1052588002971 ATP binding site [chemical binding]; other site 1052588002972 Q-loop/lid; other site 1052588002973 ABC transporter signature motif; other site 1052588002974 Walker B; other site 1052588002975 D-loop; other site 1052588002976 H-loop/switch region; other site 1052588002977 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1052588002978 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052588002979 NAD binding site [chemical binding]; other site 1052588002980 substrate binding site [chemical binding]; other site 1052588002981 putative active site [active] 1052588002982 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052588002983 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052588002984 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052588002985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1052588002986 hypothetical protein; Provisional; Region: PRK13676 1052588002987 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1052588002988 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1052588002989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588002990 active site 1052588002991 motif I; other site 1052588002992 motif II; other site 1052588002993 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1052588002994 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1052588002995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588002996 FeS/SAM binding site; other site 1052588002997 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1052588002998 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1052588002999 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1052588003000 TrkA-C domain; Region: TrkA_C; pfam02080 1052588003001 enoyl-CoA hydratase; Provisional; Region: PRK07659 1052588003002 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588003003 substrate binding site [chemical binding]; other site 1052588003004 oxyanion hole (OAH) forming residues; other site 1052588003005 trimer interface [polypeptide binding]; other site 1052588003006 YhzD-like protein; Region: YhzD; pfam14120 1052588003007 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1052588003008 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1052588003009 Walker A/P-loop; other site 1052588003010 ATP binding site [chemical binding]; other site 1052588003011 Q-loop/lid; other site 1052588003012 ABC transporter signature motif; other site 1052588003013 Walker B; other site 1052588003014 D-loop; other site 1052588003015 H-loop/switch region; other site 1052588003016 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1052588003017 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052588003018 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1052588003019 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1052588003020 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1052588003021 active site 1052588003022 metal binding site [ion binding]; metal-binding site 1052588003023 DNA binding site [nucleotide binding] 1052588003024 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1052588003025 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1052588003026 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1052588003027 generic binding surface II; other site 1052588003028 generic binding surface I; other site 1052588003029 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052588003030 Zn2+ binding site [ion binding]; other site 1052588003031 Mg2+ binding site [ion binding]; other site 1052588003032 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1052588003033 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1052588003034 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1052588003035 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1052588003036 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1052588003037 transcriptional regulator Hpr; Provisional; Region: PRK13777 1052588003038 MarR family; Region: MarR; pfam01047 1052588003039 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1052588003040 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1052588003041 homodimer interface [polypeptide binding]; other site 1052588003042 substrate-cofactor binding pocket; other site 1052588003043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588003044 catalytic residue [active] 1052588003045 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1052588003046 HIT family signature motif; other site 1052588003047 catalytic residue [active] 1052588003048 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052588003049 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052588003050 Walker A/P-loop; other site 1052588003051 ATP binding site [chemical binding]; other site 1052588003052 Q-loop/lid; other site 1052588003053 ABC transporter signature motif; other site 1052588003054 Walker B; other site 1052588003055 D-loop; other site 1052588003056 H-loop/switch region; other site 1052588003057 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1052588003058 EcsC protein family; Region: EcsC; pfam12787 1052588003059 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052588003060 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1052588003061 metal binding site [ion binding]; metal-binding site 1052588003062 dimer interface [polypeptide binding]; other site 1052588003063 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1052588003064 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1052588003065 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1052588003066 Transglycosylase; Region: Transgly; pfam00912 1052588003067 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052588003068 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1052588003069 substrate binding site [chemical binding]; other site 1052588003070 active site 1052588003071 ferrochelatase; Provisional; Region: PRK12435 1052588003072 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1052588003073 C-terminal domain interface [polypeptide binding]; other site 1052588003074 active site 1052588003075 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1052588003076 active site 1052588003077 N-terminal domain interface [polypeptide binding]; other site 1052588003078 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1052588003079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1052588003080 SEA domain; Region: SEA; cl02507 1052588003081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588003082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588003083 Predicted membrane protein [Function unknown]; Region: COG1511 1052588003084 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1052588003085 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1052588003086 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1052588003087 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1052588003088 dimer interface [polypeptide binding]; other site 1052588003089 active site 1052588003090 CoA binding pocket [chemical binding]; other site 1052588003091 Predicted membrane protein [Function unknown]; Region: COG4377 1052588003092 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052588003093 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1052588003094 putative oligomer interface [polypeptide binding]; other site 1052588003095 putative active site [active] 1052588003096 metal binding site [ion binding]; metal-binding site 1052588003097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4405 1052588003098 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052588003099 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052588003100 YhfH-like protein; Region: YhfH; pfam14149 1052588003101 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1052588003102 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1052588003103 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1052588003104 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1052588003105 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1052588003106 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052588003107 NAD(P) binding site [chemical binding]; other site 1052588003108 putative active site [active] 1052588003109 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1052588003110 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1052588003111 acyl-activating enzyme (AAE) consensus motif; other site 1052588003112 putative AMP binding site [chemical binding]; other site 1052588003113 putative active site [active] 1052588003114 putative CoA binding site [chemical binding]; other site 1052588003115 Peptidase family M48; Region: Peptidase_M48; pfam01435 1052588003116 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052588003117 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052588003118 active site 1052588003119 catalytic residues [active] 1052588003120 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052588003121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588003122 Coenzyme A binding pocket [chemical binding]; other site 1052588003123 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1052588003124 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1052588003125 putative NADP binding site [chemical binding]; other site 1052588003126 putative dimer interface [polypeptide binding]; other site 1052588003127 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1052588003128 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052588003129 siderophore binding site; other site 1052588003130 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052588003131 catalytic core [active] 1052588003132 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1052588003133 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1052588003134 dimer interface [polypeptide binding]; other site 1052588003135 active site 1052588003136 acyl-CoA synthetase; Validated; Region: PRK07638 1052588003137 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052588003138 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1052588003139 acyl-activating enzyme (AAE) consensus motif; other site 1052588003140 acyl-activating enzyme (AAE) consensus motif; other site 1052588003141 AMP binding site [chemical binding]; other site 1052588003142 active site 1052588003143 CoA binding site [chemical binding]; other site 1052588003144 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1052588003145 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1052588003146 heme-binding site [chemical binding]; other site 1052588003147 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052588003148 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588003149 dimer interface [polypeptide binding]; other site 1052588003150 putative CheW interface [polypeptide binding]; other site 1052588003151 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1052588003152 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1052588003153 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1052588003154 [2Fe-2S] cluster binding site [ion binding]; other site 1052588003155 short chain dehydrogenase; Provisional; Region: PRK06701 1052588003156 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052588003157 NAD binding site [chemical binding]; other site 1052588003158 metal binding site [ion binding]; metal-binding site 1052588003159 active site 1052588003160 IDEAL domain; Region: IDEAL; pfam08858 1052588003161 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1052588003162 oxidoreductase; Provisional; Region: PRK07985 1052588003163 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052588003164 NAD binding site [chemical binding]; other site 1052588003165 metal binding site [ion binding]; metal-binding site 1052588003166 active site 1052588003167 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1052588003168 Na binding site [ion binding]; other site 1052588003169 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1052588003170 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1052588003171 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052588003172 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052588003173 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052588003174 Catalytic site [active] 1052588003175 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1052588003176 hypothetical protein; Provisional; Region: PRK08244 1052588003177 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1052588003178 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588003179 MarR family; Region: MarR; pfam01047 1052588003180 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1052588003181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588003182 putative substrate translocation pore; other site 1052588003183 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588003184 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052588003185 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052588003186 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1052588003187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588003188 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1052588003189 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1052588003190 inhibitor-cofactor binding pocket; inhibition site 1052588003191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588003192 catalytic residue [active] 1052588003193 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588003194 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588003195 DNA binding site [nucleotide binding] 1052588003196 domain linker motif; other site 1052588003197 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1052588003198 putative dimerization interface [polypeptide binding]; other site 1052588003199 putative ligand binding site [chemical binding]; other site 1052588003200 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1052588003201 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1052588003202 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1052588003203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588003204 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588003205 putative substrate translocation pore; other site 1052588003206 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1052588003207 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1052588003208 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1052588003209 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1052588003210 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1052588003211 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1052588003212 dinuclear metal binding motif [ion binding]; other site 1052588003213 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1052588003214 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1052588003215 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1052588003216 Part of AAA domain; Region: AAA_19; pfam13245 1052588003217 Family description; Region: UvrD_C_2; pfam13538 1052588003218 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1052588003219 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1052588003220 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1052588003221 active site 1052588003222 metal binding site [ion binding]; metal-binding site 1052588003223 DNA binding site [nucleotide binding] 1052588003224 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1052588003225 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1052588003226 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1052588003227 Walker A/P-loop; other site 1052588003228 ATP binding site [chemical binding]; other site 1052588003229 Q-loop/lid; other site 1052588003230 ABC transporter signature motif; other site 1052588003231 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1052588003232 ABC transporter signature motif; other site 1052588003233 Walker B; other site 1052588003234 D-loop; other site 1052588003235 H-loop/switch region; other site 1052588003236 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1052588003237 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588003238 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1052588003239 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1052588003240 Spore germination protein GerPC; Region: GerPC; pfam10737 1052588003241 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1052588003242 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588003243 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052588003244 CotH protein; Region: CotH; pfam08757 1052588003245 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1052588003246 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1052588003247 hypothetical protein; Provisional; Region: PRK13673 1052588003248 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1052588003249 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1052588003250 active site 1052588003251 catalytic triad [active] 1052588003252 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1052588003253 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1052588003254 active site 1052588003255 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1052588003256 dimer interface [polypeptide binding]; other site 1052588003257 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1052588003258 Ligand Binding Site [chemical binding]; other site 1052588003259 Molecular Tunnel; other site 1052588003260 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1052588003261 substrate binding pocket [chemical binding]; other site 1052588003262 aspartate-rich region 2; other site 1052588003263 substrate-Mg2+ binding site; other site 1052588003264 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1052588003265 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052588003266 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052588003267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588003268 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588003269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588003270 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588003271 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588003272 DNA binding site [nucleotide binding] 1052588003273 domain linker motif; other site 1052588003274 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052588003275 dimerization interface [polypeptide binding]; other site 1052588003276 ligand binding site [chemical binding]; other site 1052588003277 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588003278 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052588003279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1052588003280 Lysine efflux permease [General function prediction only]; Region: COG1279 1052588003281 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052588003282 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588003283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588003284 homodimer interface [polypeptide binding]; other site 1052588003285 catalytic residue [active] 1052588003286 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1052588003287 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052588003288 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052588003289 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052588003290 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052588003291 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1052588003292 ligand-binding site [chemical binding]; other site 1052588003293 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1052588003294 ATP-sulfurylase; Region: ATPS; cd00517 1052588003295 active site 1052588003296 HXXH motif; other site 1052588003297 flexible loop; other site 1052588003298 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1052588003299 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1052588003300 Active Sites [active] 1052588003301 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1052588003302 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 1052588003303 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 1052588003304 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052588003305 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588003306 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1052588003307 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1052588003308 active site pocket [active] 1052588003309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588003310 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588003311 putative substrate translocation pore; other site 1052588003312 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052588003313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588003314 Coenzyme A binding pocket [chemical binding]; other site 1052588003315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588003316 Coenzyme A binding pocket [chemical binding]; other site 1052588003317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1052588003318 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1052588003319 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1052588003320 S1 domain; Region: S1_2; pfam13509 1052588003321 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1052588003322 RNA binding site [nucleotide binding]; other site 1052588003323 EDD domain protein, DegV family; Region: DegV; TIGR00762 1052588003324 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1052588003325 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052588003326 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588003327 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588003328 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052588003329 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1052588003330 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1052588003331 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1052588003332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588003333 motif II; other site 1052588003334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588003335 esterase; Provisional; Region: PRK10566 1052588003336 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052588003337 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1052588003338 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1052588003339 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1052588003340 FAD binding domain; Region: FAD_binding_4; pfam01565 1052588003341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588003342 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588003343 putative substrate translocation pore; other site 1052588003344 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1052588003345 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1052588003346 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1052588003347 heterotetramer interface [polypeptide binding]; other site 1052588003348 active site pocket [active] 1052588003349 cleavage site 1052588003350 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1052588003351 nucleotide binding site [chemical binding]; other site 1052588003352 N-acetyl-L-glutamate binding site [chemical binding]; other site 1052588003353 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1052588003354 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588003355 inhibitor-cofactor binding pocket; inhibition site 1052588003356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588003357 catalytic residue [active] 1052588003358 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1052588003359 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1052588003360 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1052588003361 catalytic site [active] 1052588003362 subunit interface [polypeptide binding]; other site 1052588003363 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1052588003364 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588003365 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1052588003366 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1052588003367 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588003368 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1052588003369 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1052588003370 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1052588003371 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1052588003372 YjzC-like protein; Region: YjzC; pfam14168 1052588003373 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1052588003374 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1052588003375 UDP-apiose/xylose synthase; Region: PLN02427 1052588003376 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1052588003377 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1052588003378 putative ligand binding site [chemical binding]; other site 1052588003379 ComZ; Region: ComZ; pfam10815 1052588003380 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1052588003381 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1052588003382 dimer interface [polypeptide binding]; other site 1052588003383 active site 1052588003384 CoA binding pocket [chemical binding]; other site 1052588003385 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1052588003386 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1052588003387 dimer interface [polypeptide binding]; other site 1052588003388 active site 1052588003389 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1052588003390 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052588003391 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052588003392 Walker A/P-loop; other site 1052588003393 ATP binding site [chemical binding]; other site 1052588003394 Q-loop/lid; other site 1052588003395 ABC transporter signature motif; other site 1052588003396 Walker B; other site 1052588003397 D-loop; other site 1052588003398 H-loop/switch region; other site 1052588003399 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1052588003400 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1052588003401 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052588003402 Walker A/P-loop; other site 1052588003403 ATP binding site [chemical binding]; other site 1052588003404 Q-loop/lid; other site 1052588003405 ABC transporter signature motif; other site 1052588003406 Walker B; other site 1052588003407 D-loop; other site 1052588003408 H-loop/switch region; other site 1052588003409 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1052588003410 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1052588003411 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1052588003412 peptide binding site [polypeptide binding]; other site 1052588003413 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052588003414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588003415 dimer interface [polypeptide binding]; other site 1052588003416 conserved gate region; other site 1052588003417 putative PBP binding loops; other site 1052588003418 ABC-ATPase subunit interface; other site 1052588003419 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052588003420 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052588003421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588003422 dimer interface [polypeptide binding]; other site 1052588003423 conserved gate region; other site 1052588003424 putative PBP binding loops; other site 1052588003425 ABC-ATPase subunit interface; other site 1052588003426 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1052588003427 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1052588003428 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1052588003429 active site 1052588003430 HIGH motif; other site 1052588003431 dimer interface [polypeptide binding]; other site 1052588003432 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052588003433 KMSKS motif; other site 1052588003434 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1052588003435 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1052588003436 peptide binding site [polypeptide binding]; other site 1052588003437 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1052588003438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588003439 dimer interface [polypeptide binding]; other site 1052588003440 conserved gate region; other site 1052588003441 putative PBP binding loops; other site 1052588003442 ABC-ATPase subunit interface; other site 1052588003443 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052588003444 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052588003445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588003446 dimer interface [polypeptide binding]; other site 1052588003447 conserved gate region; other site 1052588003448 putative PBP binding loops; other site 1052588003449 ABC-ATPase subunit interface; other site 1052588003450 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052588003451 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052588003452 Walker A/P-loop; other site 1052588003453 ATP binding site [chemical binding]; other site 1052588003454 Q-loop/lid; other site 1052588003455 ABC transporter signature motif; other site 1052588003456 Walker B; other site 1052588003457 D-loop; other site 1052588003458 H-loop/switch region; other site 1052588003459 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052588003460 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1052588003461 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052588003462 Walker A/P-loop; other site 1052588003463 ATP binding site [chemical binding]; other site 1052588003464 Q-loop/lid; other site 1052588003465 ABC transporter signature motif; other site 1052588003466 Walker B; other site 1052588003467 D-loop; other site 1052588003468 H-loop/switch region; other site 1052588003469 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1052588003470 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052588003471 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1052588003472 ArsC family; Region: ArsC; pfam03960 1052588003473 putative catalytic residues [active] 1052588003474 thiol/disulfide switch; other site 1052588003475 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1052588003476 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 1052588003477 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 1052588003478 oligoendopeptidase F; Region: pepF; TIGR00181 1052588003479 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1052588003480 active site 1052588003481 Zn binding site [ion binding]; other site 1052588003482 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1052588003483 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1052588003484 catalytic residues [active] 1052588003485 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1052588003486 apolar tunnel; other site 1052588003487 heme binding site [chemical binding]; other site 1052588003488 dimerization interface [polypeptide binding]; other site 1052588003489 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1052588003490 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1052588003491 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052588003492 catalytic residue [active] 1052588003493 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1052588003494 putative active site [active] 1052588003495 putative metal binding residues [ion binding]; other site 1052588003496 signature motif; other site 1052588003497 putative triphosphate binding site [ion binding]; other site 1052588003498 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1052588003499 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052588003500 synthetase active site [active] 1052588003501 NTP binding site [chemical binding]; other site 1052588003502 metal binding site [ion binding]; metal-binding site 1052588003503 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1052588003504 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1052588003505 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1052588003506 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1052588003507 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052588003508 active site 1052588003509 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1052588003510 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1052588003511 active site 1052588003512 metal binding site [ion binding]; metal-binding site 1052588003513 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1052588003514 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1052588003515 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052588003516 TrkA-N domain; Region: TrkA_N; pfam02254 1052588003517 TrkA-C domain; Region: TrkA_C; pfam02080 1052588003518 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1052588003519 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1052588003520 thiamine phosphate binding site [chemical binding]; other site 1052588003521 active site 1052588003522 pyrophosphate binding site [ion binding]; other site 1052588003523 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1052588003524 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1052588003525 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1052588003526 thiS-thiF/thiG interaction site; other site 1052588003527 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1052588003528 ThiS interaction site; other site 1052588003529 putative active site [active] 1052588003530 tetramer interface [polypeptide binding]; other site 1052588003531 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1052588003532 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1052588003533 ATP binding site [chemical binding]; other site 1052588003534 substrate interface [chemical binding]; other site 1052588003535 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1052588003536 dimer interface [polypeptide binding]; other site 1052588003537 substrate binding site [chemical binding]; other site 1052588003538 ATP binding site [chemical binding]; other site 1052588003539 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1052588003540 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1052588003541 NAD binding site [chemical binding]; other site 1052588003542 homotetramer interface [polypeptide binding]; other site 1052588003543 homodimer interface [polypeptide binding]; other site 1052588003544 substrate binding site [chemical binding]; other site 1052588003545 active site 1052588003546 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1052588003547 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1052588003548 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1052588003549 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1052588003550 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1052588003551 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1052588003552 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1052588003553 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1052588003554 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1052588003555 Part of AAA domain; Region: AAA_19; pfam13245 1052588003556 Family description; Region: UvrD_C_2; pfam13538 1052588003557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588003558 Coenzyme A binding pocket [chemical binding]; other site 1052588003559 hypothetical protein; Provisional; Region: PRK13679 1052588003560 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052588003561 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1052588003562 Putative esterase; Region: Esterase; pfam00756 1052588003563 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1052588003564 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052588003565 homodimer interface [polypeptide binding]; other site 1052588003566 substrate-cofactor binding pocket; other site 1052588003567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588003568 catalytic residue [active] 1052588003569 cystathionine beta-lyase; Provisional; Region: PRK08064 1052588003570 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052588003571 homodimer interface [polypeptide binding]; other site 1052588003572 substrate-cofactor binding pocket; other site 1052588003573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588003574 catalytic residue [active] 1052588003575 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052588003576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052588003577 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1052588003578 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052588003579 translocation protein TolB; Provisional; Region: tolB; PRK04922 1052588003580 Holin family; Region: Phage_holin_4; cl01989 1052588003581 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1052588003582 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052588003583 amidase catalytic site [active] 1052588003584 Zn binding residues [ion binding]; other site 1052588003585 substrate binding site [chemical binding]; other site 1052588003586 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052588003587 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052588003588 YolD-like protein; Region: YolD; pfam08863 1052588003589 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1052588003590 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052588003591 HTH domain; Region: HTH_11; pfam08279 1052588003592 PRD domain; Region: PRD; pfam00874 1052588003593 PRD domain; Region: PRD; pfam00874 1052588003594 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052588003595 active site 1052588003596 P-loop; other site 1052588003597 phosphorylation site [posttranslational modification] 1052588003598 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052588003599 active site 1052588003600 phosphorylation site [posttranslational modification] 1052588003601 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1052588003602 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1052588003603 active site 1052588003604 P-loop; other site 1052588003605 phosphorylation site [posttranslational modification] 1052588003606 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1052588003607 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052588003608 active site 1052588003609 phosphorylation site [posttranslational modification] 1052588003610 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1052588003611 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1052588003612 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1052588003613 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052588003614 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052588003615 Coenzyme A binding pocket [chemical binding]; other site 1052588003616 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1052588003617 putative deacylase active site [active] 1052588003618 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1052588003619 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1052588003620 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 1052588003621 UbiA prenyltransferase family; Region: UbiA; pfam01040 1052588003622 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052588003623 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1052588003624 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052588003625 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 1052588003626 NodB motif; other site 1052588003627 active site 1052588003628 catalytic site [active] 1052588003629 Zn binding site [ion binding]; other site 1052588003630 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1052588003631 Putative motility protein; Region: YjfB_motility; pfam14070 1052588003632 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1052588003633 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1052588003634 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1052588003635 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1052588003636 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1052588003637 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1052588003638 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1052588003639 4Fe-4S binding domain; Region: Fer4; pfam00037 1052588003640 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1052588003641 [4Fe-4S] binding site [ion binding]; other site 1052588003642 molybdopterin cofactor binding site; other site 1052588003643 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1052588003644 molybdopterin cofactor binding site; other site 1052588003645 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1052588003646 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052588003647 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1052588003648 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1052588003649 nudix motif; other site 1052588003650 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052588003651 Cytochrome P450; Region: p450; cl12078 1052588003652 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052588003653 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1052588003654 active site 1052588003655 TDP-binding site; other site 1052588003656 acceptor substrate-binding pocket; other site 1052588003657 homodimer interface [polypeptide binding]; other site 1052588003658 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1052588003659 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052588003660 active site 1052588003661 TIGR00245 family protein; Region: TIGR00245 1052588003662 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1052588003663 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1052588003664 Walker A/P-loop; other site 1052588003665 ATP binding site [chemical binding]; other site 1052588003666 Q-loop/lid; other site 1052588003667 ABC transporter signature motif; other site 1052588003668 Walker B; other site 1052588003669 D-loop; other site 1052588003670 H-loop/switch region; other site 1052588003671 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1052588003672 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1052588003673 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1052588003674 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052588003675 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588003676 Glucuronate isomerase; Region: UxaC; pfam02614 1052588003677 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1052588003678 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1052588003679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588003680 putative substrate translocation pore; other site 1052588003681 Malate/L-lactate dehydrogenase; Region: Ldh_2; pfam02615 1052588003682 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052588003683 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1052588003684 putative NAD(P) binding site [chemical binding]; other site 1052588003685 catalytic Zn binding site [ion binding]; other site 1052588003686 structural Zn binding site [ion binding]; other site 1052588003687 mannonate dehydratase; Provisional; Region: PRK03906 1052588003688 mannonate dehydratase; Region: uxuA; TIGR00695 1052588003689 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1052588003690 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1052588003691 putative NAD(P) binding site [chemical binding]; other site 1052588003692 active site 1052588003693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588003694 D-galactonate transporter; Region: 2A0114; TIGR00893 1052588003695 putative substrate translocation pore; other site 1052588003696 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588003697 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588003698 DNA binding site [nucleotide binding] 1052588003699 domain linker motif; other site 1052588003700 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052588003701 dimerization interface [polypeptide binding]; other site 1052588003702 ligand binding site [chemical binding]; other site 1052588003703 altronate oxidoreductase; Provisional; Region: PRK03643 1052588003704 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1052588003705 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1052588003706 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1052588003707 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1052588003708 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1052588003709 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1052588003710 DinB family; Region: DinB; pfam05163 1052588003711 DinB superfamily; Region: DinB_2; pfam12867 1052588003712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588003713 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052588003714 Walker A motif; other site 1052588003715 ATP binding site [chemical binding]; other site 1052588003716 Walker B motif; other site 1052588003717 arginine finger; other site 1052588003718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588003719 binding surface 1052588003720 TPR motif; other site 1052588003721 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588003722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588003723 binding surface 1052588003724 TPR motif; other site 1052588003725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1052588003726 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1052588003727 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052588003728 amidase catalytic site [active] 1052588003729 Zn binding residues [ion binding]; other site 1052588003730 substrate binding site [chemical binding]; other site 1052588003731 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1052588003732 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588003733 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052588003734 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052588003735 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1052588003736 pentamer interface [polypeptide binding]; other site 1052588003737 dodecaamer interface [polypeptide binding]; other site 1052588003738 Phage-related replication protein [General function prediction only]; Region: COG4195 1052588003739 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052588003740 dimanganese center [ion binding]; other site 1052588003741 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1052588003742 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052588003743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588003744 non-specific DNA binding site [nucleotide binding]; other site 1052588003745 salt bridge; other site 1052588003746 sequence-specific DNA binding site [nucleotide binding]; other site 1052588003747 Transcriptional regulator; Region: Rrf2; cl17282 1052588003748 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052588003749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588003750 Walker A motif; other site 1052588003751 ATP binding site [chemical binding]; other site 1052588003752 Walker B motif; other site 1052588003753 positive control sigma-like factor; Validated; Region: PRK06930 1052588003754 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588003755 DNA binding residues [nucleotide binding] 1052588003756 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1052588003757 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1052588003758 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1052588003759 Terminase-like family; Region: Terminase_6; pfam03237 1052588003760 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1052588003761 Phage capsid family; Region: Phage_capsid; pfam05065 1052588003762 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1052588003763 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1052588003764 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1052588003765 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1052588003766 Phage XkdN-like protein; Region: XkdN; pfam08890 1052588003767 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1052588003768 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1052588003769 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1052588003770 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052588003771 catalytic residue [active] 1052588003772 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1052588003773 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588003774 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 1052588003775 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1052588003776 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1052588003777 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1052588003778 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1052588003779 XkdW protein; Region: XkdW; pfam09636 1052588003780 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1052588003781 Haemolysin XhlA; Region: XhlA; pfam10779 1052588003782 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1052588003783 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052588003784 amidase catalytic site [active] 1052588003785 Zn binding residues [ion binding]; other site 1052588003786 substrate binding site [chemical binding]; other site 1052588003787 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588003788 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052588003789 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052588003790 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1052588003791 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1052588003792 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1052588003793 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1052588003794 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1052588003795 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052588003796 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588003797 Zn binding site [ion binding]; other site 1052588003798 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052588003799 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588003800 Zn binding site [ion binding]; other site 1052588003801 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1052588003802 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1052588003803 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1052588003804 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1052588003805 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052588003806 Ligand binding site; other site 1052588003807 Putative Catalytic site; other site 1052588003808 DXD motif; other site 1052588003809 Trypsin; Region: Trypsin; pfam00089 1052588003810 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052588003811 protein binding site [polypeptide binding]; other site 1052588003812 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 1052588003813 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1052588003814 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1052588003815 SxDxEG motif; other site 1052588003816 active site 1052588003817 metal binding site [ion binding]; metal-binding site 1052588003818 homopentamer interface [polypeptide binding]; other site 1052588003819 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052588003820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588003821 dimer interface [polypeptide binding]; other site 1052588003822 conserved gate region; other site 1052588003823 putative PBP binding loops; other site 1052588003824 ABC-ATPase subunit interface; other site 1052588003825 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052588003826 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052588003827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588003828 dimer interface [polypeptide binding]; other site 1052588003829 conserved gate region; other site 1052588003830 putative PBP binding loops; other site 1052588003831 ABC-ATPase subunit interface; other site 1052588003832 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052588003833 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052588003834 Walker A/P-loop; other site 1052588003835 ATP binding site [chemical binding]; other site 1052588003836 Q-loop/lid; other site 1052588003837 ABC transporter signature motif; other site 1052588003838 Walker B; other site 1052588003839 D-loop; other site 1052588003840 H-loop/switch region; other site 1052588003841 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052588003842 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1052588003843 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1052588003844 peptide binding site [polypeptide binding]; other site 1052588003845 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1052588003846 dimer interface [polypeptide binding]; other site 1052588003847 catalytic triad [active] 1052588003848 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1052588003849 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1052588003850 active site 1052588003851 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052588003852 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052588003853 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1052588003854 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052588003855 Walker A/P-loop; other site 1052588003856 ATP binding site [chemical binding]; other site 1052588003857 Q-loop/lid; other site 1052588003858 ABC transporter signature motif; other site 1052588003859 Walker B; other site 1052588003860 D-loop; other site 1052588003861 H-loop/switch region; other site 1052588003862 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1052588003863 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1052588003864 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1052588003865 Amidinotransferase; Region: Amidinotransf; pfam02274 1052588003866 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1052588003867 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1052588003868 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1052588003869 heme-binding site [chemical binding]; other site 1052588003870 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1052588003871 FAD binding pocket [chemical binding]; other site 1052588003872 FAD binding motif [chemical binding]; other site 1052588003873 phosphate binding motif [ion binding]; other site 1052588003874 beta-alpha-beta structure motif; other site 1052588003875 NAD binding pocket [chemical binding]; other site 1052588003876 Heme binding pocket [chemical binding]; other site 1052588003877 Predicted membrane protein [Function unknown]; Region: COG2323 1052588003878 DinB superfamily; Region: DinB_2; pfam12867 1052588003879 metal-dependent hydrolase; Provisional; Region: PRK13291 1052588003880 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052588003881 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052588003882 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1052588003883 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052588003884 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1052588003885 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1052588003886 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1052588003887 putative active site [active] 1052588003888 putative substrate binding site [chemical binding]; other site 1052588003889 putative cosubstrate binding site; other site 1052588003890 catalytic site [active] 1052588003891 glutamate 5-kinase; Region: proB; TIGR01027 1052588003892 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1052588003893 nucleotide binding site [chemical binding]; other site 1052588003894 homotetrameric interface [polypeptide binding]; other site 1052588003895 putative phosphate binding site [ion binding]; other site 1052588003896 putative allosteric binding site; other site 1052588003897 PUA domain; Region: PUA; pfam01472 1052588003898 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1052588003899 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1052588003900 putative catalytic cysteine [active] 1052588003901 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1052588003902 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1052588003903 MarR family; Region: MarR; pfam01047 1052588003904 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1052588003905 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1052588003906 nucleoside/Zn binding site; other site 1052588003907 dimer interface [polypeptide binding]; other site 1052588003908 catalytic motif [active] 1052588003909 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052588003910 catalytic core [active] 1052588003911 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1052588003912 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1052588003913 THF binding site; other site 1052588003914 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052588003915 substrate binding site [chemical binding]; other site 1052588003916 THF binding site; other site 1052588003917 zinc-binding site [ion binding]; other site 1052588003918 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052588003919 active site 1052588003920 catalytic residues [active] 1052588003921 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588003922 Cobalt transport protein; Region: CbiQ; pfam02361 1052588003923 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1052588003924 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052588003925 Walker A/P-loop; other site 1052588003926 ATP binding site [chemical binding]; other site 1052588003927 Q-loop/lid; other site 1052588003928 ABC transporter signature motif; other site 1052588003929 Walker B; other site 1052588003930 D-loop; other site 1052588003931 H-loop/switch region; other site 1052588003932 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052588003933 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1052588003934 Walker A/P-loop; other site 1052588003935 ATP binding site [chemical binding]; other site 1052588003936 Q-loop/lid; other site 1052588003937 ABC transporter signature motif; other site 1052588003938 Walker B; other site 1052588003939 D-loop; other site 1052588003940 H-loop/switch region; other site 1052588003941 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1052588003942 YKOF-related Family; Region: Ykof; pfam07615 1052588003943 YKOF-related Family; Region: Ykof; pfam07615 1052588003944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588003945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588003946 active site 1052588003947 phosphorylation site [posttranslational modification] 1052588003948 intermolecular recognition site; other site 1052588003949 dimerization interface [polypeptide binding]; other site 1052588003950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588003951 DNA binding site [nucleotide binding] 1052588003952 Predicted membrane protein [Function unknown]; Region: COG3212 1052588003953 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052588003954 Predicted membrane protein [Function unknown]; Region: COG3212 1052588003955 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052588003956 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1052588003957 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1052588003958 MgtE intracellular N domain; Region: MgtE_N; smart00924 1052588003959 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1052588003960 Divalent cation transporter; Region: MgtE; pfam01769 1052588003961 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1052588003962 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052588003963 DNA binding residues [nucleotide binding] 1052588003964 putative dimer interface [polypeptide binding]; other site 1052588003965 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588003966 MarR family; Region: MarR; pfam01047 1052588003967 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 1052588003968 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1052588003969 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1052588003970 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052588003971 putative active site [active] 1052588003972 putative metal binding site [ion binding]; other site 1052588003973 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1052588003974 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052588003975 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052588003976 Ligand binding site; other site 1052588003977 Putative Catalytic site; other site 1052588003978 DXD motif; other site 1052588003979 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1052588003980 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1052588003981 active site 1052588003982 DNA binding site [nucleotide binding] 1052588003983 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1052588003984 nucleotide binding site [chemical binding]; other site 1052588003985 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1052588003986 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1052588003987 putative DNA binding site [nucleotide binding]; other site 1052588003988 putative homodimer interface [polypeptide binding]; other site 1052588003989 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1052588003990 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1052588003991 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1052588003992 PAS domain S-box; Region: sensory_box; TIGR00229 1052588003993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052588003994 metal binding site [ion binding]; metal-binding site 1052588003995 active site 1052588003996 I-site; other site 1052588003997 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1052588003998 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1052588003999 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052588004000 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1052588004001 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1052588004002 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588004003 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1052588004004 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052588004005 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1052588004006 heat shock protein HtpX; Provisional; Region: PRK05457 1052588004007 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1052588004008 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1052588004009 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052588004010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588004011 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1052588004012 putative active site [active] 1052588004013 heme pocket [chemical binding]; other site 1052588004014 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052588004015 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1052588004016 putative active site [active] 1052588004017 heme pocket [chemical binding]; other site 1052588004018 PAS domain; Region: PAS; smart00091 1052588004019 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052588004020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588004021 putative active site [active] 1052588004022 heme pocket [chemical binding]; other site 1052588004023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588004024 dimer interface [polypeptide binding]; other site 1052588004025 phosphorylation site [posttranslational modification] 1052588004026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588004027 ATP binding site [chemical binding]; other site 1052588004028 Mg2+ binding site [ion binding]; other site 1052588004029 G-X-G motif; other site 1052588004030 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1052588004031 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1052588004032 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1052588004033 DNA binding site [nucleotide binding] 1052588004034 active site 1052588004035 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1052588004036 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1052588004037 Predicted kinase [General function prediction only]; Region: COG4857 1052588004038 Phosphotransferase enzyme family; Region: APH; pfam01636 1052588004039 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1052588004040 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1052588004041 putative active site [active] 1052588004042 catalytic triad [active] 1052588004043 putative dimer interface [polypeptide binding]; other site 1052588004044 transaminase; Reviewed; Region: PRK08068 1052588004045 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588004046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588004047 homodimer interface [polypeptide binding]; other site 1052588004048 catalytic residue [active] 1052588004049 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 1052588004050 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1052588004051 dimer interface [polypeptide binding]; other site 1052588004052 active site 1052588004053 catalytic residue [active] 1052588004054 metal binding site [ion binding]; metal-binding site 1052588004055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588004056 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1052588004057 motif II; other site 1052588004058 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1052588004059 intersubunit interface [polypeptide binding]; other site 1052588004060 active site 1052588004061 Zn2+ binding site [ion binding]; other site 1052588004062 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1052588004063 Cupin domain; Region: Cupin_2; pfam07883 1052588004064 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1052588004065 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052588004066 Cache domain; Region: Cache_1; pfam02743 1052588004067 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1052588004068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588004069 dimer interface [polypeptide binding]; other site 1052588004070 phosphorylation site [posttranslational modification] 1052588004071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588004072 ATP binding site [chemical binding]; other site 1052588004073 Mg2+ binding site [ion binding]; other site 1052588004074 G-X-G motif; other site 1052588004075 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588004076 MarR family; Region: MarR; pfam01047 1052588004077 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1052588004078 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1052588004079 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1052588004080 ligand binding site [chemical binding]; other site 1052588004081 flagellar motor protein MotA; Validated; Region: PRK08124 1052588004082 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1052588004083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588004084 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052588004085 Walker A motif; other site 1052588004086 ATP binding site [chemical binding]; other site 1052588004087 Walker B motif; other site 1052588004088 arginine finger; other site 1052588004089 UvrB/uvrC motif; Region: UVR; pfam02151 1052588004090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588004091 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052588004092 Walker A motif; other site 1052588004093 ATP binding site [chemical binding]; other site 1052588004094 Walker B motif; other site 1052588004095 arginine finger; other site 1052588004096 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1052588004097 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1052588004098 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1052588004099 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1052588004100 Ligand Binding Site [chemical binding]; other site 1052588004101 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1052588004102 active site 1052588004103 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1052588004104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588004105 FeS/SAM binding site; other site 1052588004106 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1052588004107 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052588004108 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052588004109 short chain dehydrogenase; Provisional; Region: PRK06500 1052588004110 classical (c) SDRs; Region: SDR_c; cd05233 1052588004111 NAD(P) binding site [chemical binding]; other site 1052588004112 active site 1052588004113 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1052588004114 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588004115 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1052588004116 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1052588004117 active site 1052588004118 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1052588004119 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1052588004120 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1052588004121 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052588004122 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1052588004123 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052588004124 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052588004125 catalytic residues [active] 1052588004126 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1052588004127 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052588004128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588004129 motif II; other site 1052588004130 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1052588004131 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1052588004132 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1052588004133 active site 1052588004134 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588004135 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588004136 DNA binding site [nucleotide binding] 1052588004137 domain linker motif; other site 1052588004138 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1052588004139 putative dimerization interface [polypeptide binding]; other site 1052588004140 putative ligand binding site [chemical binding]; other site 1052588004141 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052588004142 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1052588004143 PRD domain; Region: PRD; pfam00874 1052588004144 PRD domain; Region: PRD; pfam00874 1052588004145 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052588004146 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1052588004147 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588004148 active site turn [active] 1052588004149 phosphorylation site [posttranslational modification] 1052588004150 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1052588004151 HPr interaction site; other site 1052588004152 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052588004153 active site 1052588004154 phosphorylation site [posttranslational modification] 1052588004155 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052588004156 dimerization domain swap beta strand [polypeptide binding]; other site 1052588004157 regulatory protein interface [polypeptide binding]; other site 1052588004158 active site 1052588004159 regulatory phosphorylation site [posttranslational modification]; other site 1052588004160 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1052588004161 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1052588004162 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1052588004163 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1052588004164 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1052588004165 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1052588004166 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588004167 FeS/SAM binding site; other site 1052588004168 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588004169 Coenzyme A binding pocket [chemical binding]; other site 1052588004170 Cache domain; Region: Cache_1; pfam02743 1052588004171 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588004172 dimerization interface [polypeptide binding]; other site 1052588004173 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052588004174 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588004175 dimer interface [polypeptide binding]; other site 1052588004176 putative CheW interface [polypeptide binding]; other site 1052588004177 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1052588004178 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1052588004179 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1052588004180 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1052588004181 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588004182 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588004183 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052588004184 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052588004185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588004186 putative active site [active] 1052588004187 heme pocket [chemical binding]; other site 1052588004188 PAS fold; Region: PAS; pfam00989 1052588004189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588004190 putative active site [active] 1052588004191 heme pocket [chemical binding]; other site 1052588004192 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052588004193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588004194 putative active site [active] 1052588004195 heme pocket [chemical binding]; other site 1052588004196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588004197 dimer interface [polypeptide binding]; other site 1052588004198 phosphorylation site [posttranslational modification] 1052588004199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588004200 ATP binding site [chemical binding]; other site 1052588004201 Mg2+ binding site [ion binding]; other site 1052588004202 G-X-G motif; other site 1052588004203 aminotransferase A; Validated; Region: PRK07683 1052588004204 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588004205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588004206 homodimer interface [polypeptide binding]; other site 1052588004207 catalytic residue [active] 1052588004208 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1052588004209 putative CheA interaction surface; other site 1052588004210 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588004211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588004212 active site 1052588004213 phosphorylation site [posttranslational modification] 1052588004214 intermolecular recognition site; other site 1052588004215 dimerization interface [polypeptide binding]; other site 1052588004216 YkyB-like protein; Region: YkyB; pfam14177 1052588004217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588004218 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052588004219 putative substrate translocation pore; other site 1052588004220 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588004221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1052588004222 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1052588004223 phosphodiesterase YaeI; Provisional; Region: PRK11340 1052588004224 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1052588004225 putative active site [active] 1052588004226 putative metal binding site [ion binding]; other site 1052588004227 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1052588004228 short chain dehydrogenase; Provisional; Region: PRK07677 1052588004229 NAD(P) binding site [chemical binding]; other site 1052588004230 substrate binding site [chemical binding]; other site 1052588004231 homotetramer interface [polypeptide binding]; other site 1052588004232 active site 1052588004233 homodimer interface [polypeptide binding]; other site 1052588004234 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1052588004235 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1052588004236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 1052588004237 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1052588004238 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1052588004239 FOG: CBS domain [General function prediction only]; Region: COG0517 1052588004240 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1052588004241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588004242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588004243 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588004244 dimerization interface [polypeptide binding]; other site 1052588004245 flavodoxin; Provisional; Region: PRK06703 1052588004246 BNR repeat-like domain; Region: BNR_2; pfam13088 1052588004247 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1052588004248 flavodoxin, short chain; Region: flav_short; TIGR01753 1052588004249 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1052588004250 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1052588004251 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1052588004252 active site 1052588004253 trimer interface [polypeptide binding]; other site 1052588004254 substrate binding site [chemical binding]; other site 1052588004255 CoA binding site [chemical binding]; other site 1052588004256 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052588004257 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1052588004258 metal binding site [ion binding]; metal-binding site 1052588004259 putative dimer interface [polypeptide binding]; other site 1052588004260 hypothetical protein; Provisional; Region: PRK03094 1052588004261 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1052588004262 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1052588004263 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1052588004264 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1052588004265 dimer interface [polypeptide binding]; other site 1052588004266 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1052588004267 catalytic triad [active] 1052588004268 peroxidatic and resolving cysteines [active] 1052588004269 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052588004270 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052588004271 catalytic residues [active] 1052588004272 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1052588004273 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1052588004274 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1052588004275 GTP binding site; other site 1052588004276 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1052588004277 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1052588004278 ATP binding site [chemical binding]; other site 1052588004279 substrate interface [chemical binding]; other site 1052588004280 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1052588004281 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1052588004282 dimer interface [polypeptide binding]; other site 1052588004283 putative functional site; other site 1052588004284 putative MPT binding site; other site 1052588004285 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1052588004286 Walker A motif; other site 1052588004287 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1052588004288 MoaE homodimer interface [polypeptide binding]; other site 1052588004289 MoaD interaction [polypeptide binding]; other site 1052588004290 active site residues [active] 1052588004291 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1052588004292 MoaE interaction surface [polypeptide binding]; other site 1052588004293 MoeB interaction surface [polypeptide binding]; other site 1052588004294 thiocarboxylated glycine; other site 1052588004295 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588004296 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052588004297 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1052588004298 Walker A/P-loop; other site 1052588004299 ATP binding site [chemical binding]; other site 1052588004300 Q-loop/lid; other site 1052588004301 ABC transporter signature motif; other site 1052588004302 Walker B; other site 1052588004303 D-loop; other site 1052588004304 H-loop/switch region; other site 1052588004305 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588004306 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052588004307 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1052588004308 Walker A/P-loop; other site 1052588004309 ATP binding site [chemical binding]; other site 1052588004310 Q-loop/lid; other site 1052588004311 ABC transporter signature motif; other site 1052588004312 Walker B; other site 1052588004313 D-loop; other site 1052588004314 H-loop/switch region; other site 1052588004315 Yip1 domain; Region: Yip1; pfam04893 1052588004316 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1052588004317 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1052588004318 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052588004319 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588004320 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052588004321 Walker A/P-loop; other site 1052588004322 ATP binding site [chemical binding]; other site 1052588004323 Q-loop/lid; other site 1052588004324 ABC transporter signature motif; other site 1052588004325 Walker B; other site 1052588004326 D-loop; other site 1052588004327 H-loop/switch region; other site 1052588004328 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052588004329 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052588004330 FtsX-like permease family; Region: FtsX; pfam02687 1052588004331 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052588004332 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1052588004333 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1052588004334 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1052588004335 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1052588004336 putative substrate binding site [chemical binding]; other site 1052588004337 putative ATP binding site [chemical binding]; other site 1052588004338 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1052588004339 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052588004340 active site 1052588004341 phosphorylation site [posttranslational modification] 1052588004342 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1052588004343 active site 1052588004344 P-loop; other site 1052588004345 phosphorylation site [posttranslational modification] 1052588004346 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1052588004347 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052588004348 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052588004349 Catalytic site [active] 1052588004350 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1052588004351 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052588004352 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052588004353 ABC transporter; Region: ABC_tran_2; pfam12848 1052588004354 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052588004355 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1052588004356 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1052588004357 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1052588004358 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1052588004359 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1052588004360 rod-share determining protein MreBH; Provisional; Region: PRK13929 1052588004361 MreB and similar proteins; Region: MreB_like; cd10225 1052588004362 nucleotide binding site [chemical binding]; other site 1052588004363 Mg binding site [ion binding]; other site 1052588004364 putative protofilament interaction site [polypeptide binding]; other site 1052588004365 RodZ interaction site [polypeptide binding]; other site 1052588004366 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1052588004367 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1052588004368 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1052588004369 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588004370 putative active site [active] 1052588004371 heme pocket [chemical binding]; other site 1052588004372 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588004373 dimer interface [polypeptide binding]; other site 1052588004374 phosphorylation site [posttranslational modification] 1052588004375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588004376 ATP binding site [chemical binding]; other site 1052588004377 Mg2+ binding site [ion binding]; other site 1052588004378 G-X-G motif; other site 1052588004379 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1052588004380 putative active site pocket [active] 1052588004381 dimerization interface [polypeptide binding]; other site 1052588004382 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1052588004383 putative active site pocket [active] 1052588004384 dimerization interface [polypeptide binding]; other site 1052588004385 putative catalytic residue [active] 1052588004386 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052588004387 TrkA-N domain; Region: TrkA_N; pfam02254 1052588004388 TrkA-C domain; Region: TrkA_C; pfam02080 1052588004389 adenine deaminase; Region: ade; TIGR01178 1052588004390 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052588004391 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1052588004392 active site 1052588004393 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1052588004394 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1052588004395 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1052588004396 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1052588004397 hypothetical protein; Provisional; Region: PRK13667 1052588004398 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1052588004399 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588004400 active site 1052588004401 motif I; other site 1052588004402 motif II; other site 1052588004403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588004404 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1052588004405 active site 1052588004406 catalytic residues [active] 1052588004407 metal binding site [ion binding]; metal-binding site 1052588004408 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1052588004409 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1052588004410 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052588004411 TPP-binding site [chemical binding]; other site 1052588004412 tetramer interface [polypeptide binding]; other site 1052588004413 heterodimer interface [polypeptide binding]; other site 1052588004414 phosphorylation loop region [posttranslational modification] 1052588004415 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052588004416 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052588004417 alpha subunit interface [polypeptide binding]; other site 1052588004418 TPP binding site [chemical binding]; other site 1052588004419 heterodimer interface [polypeptide binding]; other site 1052588004420 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052588004421 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1052588004422 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052588004423 E3 interaction surface; other site 1052588004424 lipoyl attachment site [posttranslational modification]; other site 1052588004425 e3 binding domain; Region: E3_binding; pfam02817 1052588004426 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1052588004427 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1052588004428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1052588004429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588004430 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052588004431 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1052588004432 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1052588004433 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1052588004434 homodimer interface [polypeptide binding]; other site 1052588004435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588004436 catalytic residue [active] 1052588004437 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1052588004438 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1052588004439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1052588004440 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1052588004441 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1052588004442 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1052588004443 active site 1052588004444 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1052588004445 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1052588004446 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1052588004447 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1052588004448 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052588004449 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1052588004450 active site 1052588004451 Zn binding site [ion binding]; other site 1052588004452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588004453 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1052588004454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588004455 DNA binding residues [nucleotide binding] 1052588004456 Putative zinc-finger; Region: zf-HC2; pfam13490 1052588004457 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1052588004458 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1052588004459 G1 box; other site 1052588004460 putative GEF interaction site [polypeptide binding]; other site 1052588004461 GTP/Mg2+ binding site [chemical binding]; other site 1052588004462 Switch I region; other site 1052588004463 G2 box; other site 1052588004464 G3 box; other site 1052588004465 Switch II region; other site 1052588004466 G4 box; other site 1052588004467 G5 box; other site 1052588004468 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1052588004469 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1052588004470 YlaH-like protein; Region: YlaH; pfam14036 1052588004471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 1052588004472 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1052588004473 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052588004474 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1052588004475 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1052588004476 putative active site [active] 1052588004477 PhoH-like protein; Region: PhoH; pfam02562 1052588004478 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1052588004479 glutaminase A; Region: Gln_ase; TIGR03814 1052588004480 hypothetical protein; Provisional; Region: PRK13666 1052588004481 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1052588004482 pyruvate carboxylase; Reviewed; Region: PRK12999 1052588004483 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588004484 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1052588004485 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1052588004486 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1052588004487 active site 1052588004488 catalytic residues [active] 1052588004489 metal binding site [ion binding]; metal-binding site 1052588004490 homodimer binding site [polypeptide binding]; other site 1052588004491 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052588004492 carboxyltransferase (CT) interaction site; other site 1052588004493 biotinylation site [posttranslational modification]; other site 1052588004494 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1052588004495 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1052588004496 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1052588004497 UbiA prenyltransferase family; Region: UbiA; pfam01040 1052588004498 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1052588004499 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1052588004500 Cytochrome c; Region: Cytochrom_C; pfam00034 1052588004501 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1052588004502 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1052588004503 D-pathway; other site 1052588004504 Putative ubiquinol binding site [chemical binding]; other site 1052588004505 Low-spin heme (heme b) binding site [chemical binding]; other site 1052588004506 Putative water exit pathway; other site 1052588004507 Binuclear center (heme o3/CuB) [ion binding]; other site 1052588004508 K-pathway; other site 1052588004509 Putative proton exit pathway; other site 1052588004510 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1052588004511 Subunit I/III interface [polypeptide binding]; other site 1052588004512 Subunit III/IV interface [polypeptide binding]; other site 1052588004513 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1052588004514 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 1052588004515 YugN-like family; Region: YugN; pfam08868 1052588004516 FOG: CBS domain [General function prediction only]; Region: COG0517 1052588004517 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1052588004518 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1052588004519 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1052588004520 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1052588004521 Putative coat protein; Region: YlbD_coat; pfam14071 1052588004522 YlbE-like protein; Region: YlbE; pfam14003 1052588004523 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1052588004524 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 1052588004525 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1052588004526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588004527 S-adenosylmethionine binding site [chemical binding]; other site 1052588004528 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1052588004529 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1052588004530 active site 1052588004531 (T/H)XGH motif; other site 1052588004532 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1052588004533 Nucleoside recognition; Region: Gate; pfam07670 1052588004534 Nucleoside recognition; Region: Gate; pfam07670 1052588004535 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1052588004536 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1052588004537 nucleophile elbow; other site 1052588004538 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1052588004539 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1052588004540 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1052588004541 protein binding site [polypeptide binding]; other site 1052588004542 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1052588004543 hypothetical protein; Provisional; Region: PRK13670 1052588004544 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1052588004545 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1052588004546 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1052588004547 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1052588004548 hypothetical protein; Provisional; Region: PRK13688 1052588004549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588004550 Coenzyme A binding pocket [chemical binding]; other site 1052588004551 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 1052588004552 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1052588004553 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1052588004554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1052588004555 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1052588004556 mraZ protein; Region: TIGR00242 1052588004557 MraZ protein; Region: MraZ; pfam02381 1052588004558 MraZ protein; Region: MraZ; pfam02381 1052588004559 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1052588004560 MraW methylase family; Region: Methyltransf_5; pfam01795 1052588004561 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1052588004562 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052588004563 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588004564 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052588004565 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1052588004566 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1052588004567 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1052588004568 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588004569 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052588004570 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1052588004571 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1052588004572 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1052588004573 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052588004574 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052588004575 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1052588004576 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1052588004577 Mg++ binding site [ion binding]; other site 1052588004578 putative catalytic motif [active] 1052588004579 putative substrate binding site [chemical binding]; other site 1052588004580 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1052588004581 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052588004582 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052588004583 stage V sporulation protein E; Region: spoVE; TIGR02615 1052588004584 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1052588004585 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1052588004586 active site 1052588004587 homodimer interface [polypeptide binding]; other site 1052588004588 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1052588004589 FAD binding domain; Region: FAD_binding_4; pfam01565 1052588004590 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1052588004591 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1052588004592 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1052588004593 Cell division protein FtsQ; Region: FtsQ; pfam03799 1052588004594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1052588004595 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1052588004596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1052588004597 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1052588004598 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 1052588004599 cell division protein FtsA; Region: ftsA; TIGR01174 1052588004600 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052588004601 nucleotide binding site [chemical binding]; other site 1052588004602 Cell division protein FtsA; Region: FtsA; pfam14450 1052588004603 cell division protein FtsZ; Validated; Region: PRK09330 1052588004604 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1052588004605 nucleotide binding site [chemical binding]; other site 1052588004606 SulA interaction site; other site 1052588004607 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052588004608 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1052588004609 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1052588004610 active site 1052588004611 catalytic triad [active] 1052588004612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1052588004613 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1052588004614 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1052588004615 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1052588004616 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1052588004617 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1052588004618 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1052588004619 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588004620 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588004621 DNA binding residues [nucleotide binding] 1052588004622 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1052588004623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588004624 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052588004625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588004626 DNA binding residues [nucleotide binding] 1052588004627 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052588004628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588004629 Walker A/P-loop; other site 1052588004630 ATP binding site [chemical binding]; other site 1052588004631 Q-loop/lid; other site 1052588004632 ABC transporter signature motif; other site 1052588004633 Walker B; other site 1052588004634 D-loop; other site 1052588004635 H-loop/switch region; other site 1052588004636 acetylornithine deacetylase; Validated; Region: PRK08596 1052588004637 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1052588004638 metal binding site [ion binding]; metal-binding site 1052588004639 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1052588004640 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1052588004641 uncharacterized protein, YfiH family; Region: TIGR00726 1052588004642 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1052588004643 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052588004644 catalytic residue [active] 1052588004645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1052588004646 YGGT family; Region: YGGT; pfam02325 1052588004647 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1052588004648 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588004649 RNA binding surface [nucleotide binding]; other site 1052588004650 DivIVA protein; Region: DivIVA; pfam05103 1052588004651 DivIVA domain; Region: DivI1A_domain; TIGR03544 1052588004652 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1052588004653 lipoprotein signal peptidase; Region: lspA; TIGR00077 1052588004654 lipoprotein signal peptidase; Provisional; Region: PRK14787 1052588004655 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1052588004656 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588004657 RNA binding surface [nucleotide binding]; other site 1052588004658 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052588004659 active site 1052588004660 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1052588004661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588004662 active site 1052588004663 uracil-xanthine permease; Region: ncs2; TIGR00801 1052588004664 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1052588004665 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1052588004666 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1052588004667 dihydroorotase; Validated; Region: pyrC; PRK09357 1052588004668 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1052588004669 active site 1052588004670 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1052588004671 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1052588004672 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1052588004673 catalytic site [active] 1052588004674 subunit interface [polypeptide binding]; other site 1052588004675 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1052588004676 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588004677 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1052588004678 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1052588004679 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588004680 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1052588004681 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1052588004682 IMP binding site; other site 1052588004683 dimer interface [polypeptide binding]; other site 1052588004684 interdomain contacts; other site 1052588004685 partial ornithine binding site; other site 1052588004686 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1052588004687 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1052588004688 FAD binding pocket [chemical binding]; other site 1052588004689 FAD binding motif [chemical binding]; other site 1052588004690 phosphate binding motif [ion binding]; other site 1052588004691 beta-alpha-beta structure motif; other site 1052588004692 NAD binding pocket [chemical binding]; other site 1052588004693 Iron coordination center [ion binding]; other site 1052588004694 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1052588004695 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1052588004696 heterodimer interface [polypeptide binding]; other site 1052588004697 active site 1052588004698 FMN binding site [chemical binding]; other site 1052588004699 homodimer interface [polypeptide binding]; other site 1052588004700 substrate binding site [chemical binding]; other site 1052588004701 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1052588004702 active site 1052588004703 dimer interface [polypeptide binding]; other site 1052588004704 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588004705 active site 1052588004706 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1052588004707 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1052588004708 Active Sites [active] 1052588004709 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1052588004710 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1052588004711 ATP-sulfurylase; Region: ATPS; cd00517 1052588004712 active site 1052588004713 HXXH motif; other site 1052588004714 flexible loop; other site 1052588004715 AAA domain; Region: AAA_33; pfam13671 1052588004716 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1052588004717 ligand-binding site [chemical binding]; other site 1052588004718 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1052588004719 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1052588004720 active site 1052588004721 SAM binding site [chemical binding]; other site 1052588004722 homodimer interface [polypeptide binding]; other site 1052588004723 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1052588004724 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1052588004725 putative active site [active] 1052588004726 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1052588004727 putative active site [active] 1052588004728 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1052588004729 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1052588004730 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1052588004731 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1052588004732 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1052588004733 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1052588004734 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052588004735 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1052588004736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588004737 motif II; other site 1052588004738 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1052588004739 TIGR00255 family protein; Region: TIGR00255 1052588004740 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1052588004741 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1052588004742 Domain of unknown function (DUF370); Region: DUF370; cl00898 1052588004743 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1052588004744 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1052588004745 catalytic site [active] 1052588004746 G-X2-G-X-G-K; other site 1052588004747 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1052588004748 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1052588004749 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1052588004750 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588004751 ATP binding site [chemical binding]; other site 1052588004752 putative Mg++ binding site [ion binding]; other site 1052588004753 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588004754 nucleotide binding region [chemical binding]; other site 1052588004755 ATP-binding site [chemical binding]; other site 1052588004756 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1052588004757 active site 1052588004758 catalytic residues [active] 1052588004759 metal binding site [ion binding]; metal-binding site 1052588004760 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1052588004761 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1052588004762 putative active site [active] 1052588004763 substrate binding site [chemical binding]; other site 1052588004764 putative cosubstrate binding site; other site 1052588004765 catalytic site [active] 1052588004766 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1052588004767 substrate binding site [chemical binding]; other site 1052588004768 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1052588004769 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1052588004770 putative RNA binding site [nucleotide binding]; other site 1052588004771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588004772 S-adenosylmethionine binding site [chemical binding]; other site 1052588004773 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1052588004774 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588004775 FeS/SAM binding site; other site 1052588004776 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1052588004777 Protein phosphatase 2C; Region: PP2C; pfam00481 1052588004778 active site 1052588004779 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588004780 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1052588004781 active site 1052588004782 ATP binding site [chemical binding]; other site 1052588004783 substrate binding site [chemical binding]; other site 1052588004784 activation loop (A-loop); other site 1052588004785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1052588004786 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052588004787 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052588004788 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052588004789 GTPase RsgA; Reviewed; Region: PRK00098 1052588004790 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1052588004791 RNA binding site [nucleotide binding]; other site 1052588004792 homodimer interface [polypeptide binding]; other site 1052588004793 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1052588004794 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1052588004795 GTP/Mg2+ binding site [chemical binding]; other site 1052588004796 G4 box; other site 1052588004797 G5 box; other site 1052588004798 G1 box; other site 1052588004799 Switch I region; other site 1052588004800 G2 box; other site 1052588004801 G3 box; other site 1052588004802 Switch II region; other site 1052588004803 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1052588004804 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1052588004805 substrate binding site [chemical binding]; other site 1052588004806 hexamer interface [polypeptide binding]; other site 1052588004807 metal binding site [ion binding]; metal-binding site 1052588004808 Thiamine pyrophosphokinase; Region: TPK; cd07995 1052588004809 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1052588004810 active site 1052588004811 dimerization interface [polypeptide binding]; other site 1052588004812 thiamine binding site [chemical binding]; other site 1052588004813 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1052588004814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1052588004815 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1052588004816 DAK2 domain; Region: Dak2; pfam02734 1052588004817 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1052588004818 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1052588004819 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1052588004820 putative L-serine binding site [chemical binding]; other site 1052588004821 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Region: sda_alpha; TIGR00718 1052588004822 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1052588004823 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1052588004824 Pathogenicity locus; Region: Cdd1; pfam11731 1052588004825 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1052588004826 generic binding surface II; other site 1052588004827 ssDNA binding site; other site 1052588004828 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588004829 ATP binding site [chemical binding]; other site 1052588004830 putative Mg++ binding site [ion binding]; other site 1052588004831 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588004832 nucleotide binding region [chemical binding]; other site 1052588004833 ATP-binding site [chemical binding]; other site 1052588004834 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1052588004835 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1052588004836 putative phosphate acyltransferase; Provisional; Region: PRK05331 1052588004837 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1052588004838 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1052588004839 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1052588004840 NAD(P) binding site [chemical binding]; other site 1052588004841 homotetramer interface [polypeptide binding]; other site 1052588004842 homodimer interface [polypeptide binding]; other site 1052588004843 active site 1052588004844 acyl carrier protein; Provisional; Region: acpP; PRK00982 1052588004845 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1052588004846 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1052588004847 dimerization interface [polypeptide binding]; other site 1052588004848 active site 1052588004849 metal binding site [ion binding]; metal-binding site 1052588004850 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1052588004851 dsRNA binding site [nucleotide binding]; other site 1052588004852 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1052588004853 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1052588004854 Walker A/P-loop; other site 1052588004855 ATP binding site [chemical binding]; other site 1052588004856 Q-loop/lid; other site 1052588004857 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1052588004858 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1052588004859 ABC transporter signature motif; other site 1052588004860 Walker B; other site 1052588004861 D-loop; other site 1052588004862 H-loop/switch region; other site 1052588004863 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1052588004864 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1052588004865 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1052588004866 GTP binding site [chemical binding]; other site 1052588004867 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1052588004868 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1052588004869 putative DNA-binding protein; Validated; Region: PRK00118 1052588004870 signal recognition particle protein; Provisional; Region: PRK10867 1052588004871 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1052588004872 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1052588004873 P loop; other site 1052588004874 GTP binding site [chemical binding]; other site 1052588004875 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1052588004876 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1052588004877 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1052588004878 KH domain; Region: KH_4; pfam13083 1052588004879 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1052588004880 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1052588004881 RimM N-terminal domain; Region: RimM; pfam01782 1052588004882 PRC-barrel domain; Region: PRC; pfam05239 1052588004883 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1052588004884 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1052588004885 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1052588004886 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1052588004887 GTP/Mg2+ binding site [chemical binding]; other site 1052588004888 G4 box; other site 1052588004889 G5 box; other site 1052588004890 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1052588004891 G1 box; other site 1052588004892 G1 box; other site 1052588004893 GTP/Mg2+ binding site [chemical binding]; other site 1052588004894 Switch I region; other site 1052588004895 G2 box; other site 1052588004896 G2 box; other site 1052588004897 G3 box; other site 1052588004898 G3 box; other site 1052588004899 Switch II region; other site 1052588004900 Switch II region; other site 1052588004901 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1052588004902 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052588004903 active site 1052588004904 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1052588004905 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1052588004906 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1052588004907 CoA-ligase; Region: Ligase_CoA; pfam00549 1052588004908 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1052588004909 CoA binding domain; Region: CoA_binding; smart00881 1052588004910 CoA-ligase; Region: Ligase_CoA; pfam00549 1052588004911 DNA protecting protein DprA; Region: dprA; TIGR00732 1052588004912 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1052588004913 DNA topoisomerase I; Validated; Region: PRK05582 1052588004914 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1052588004915 active site 1052588004916 interdomain interaction site; other site 1052588004917 putative metal-binding site [ion binding]; other site 1052588004918 nucleotide binding site [chemical binding]; other site 1052588004919 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1052588004920 domain I; other site 1052588004921 DNA binding groove [nucleotide binding] 1052588004922 phosphate binding site [ion binding]; other site 1052588004923 domain II; other site 1052588004924 domain III; other site 1052588004925 nucleotide binding site [chemical binding]; other site 1052588004926 catalytic site [active] 1052588004927 domain IV; other site 1052588004928 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1052588004929 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1052588004930 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1052588004931 Glucose inhibited division protein A; Region: GIDA; pfam01134 1052588004932 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1052588004933 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1052588004934 active site 1052588004935 Int/Topo IB signature motif; other site 1052588004936 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1052588004937 active site 1052588004938 HslU subunit interaction site [polypeptide binding]; other site 1052588004939 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1052588004940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588004941 Walker A motif; other site 1052588004942 ATP binding site [chemical binding]; other site 1052588004943 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1052588004944 Walker B motif; other site 1052588004945 arginine finger; other site 1052588004946 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1052588004947 transcriptional repressor CodY; Validated; Region: PRK04158 1052588004948 CodY GAF-like domain; Region: CodY; pfam06018 1052588004949 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1052588004950 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1052588004951 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1052588004952 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1052588004953 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1052588004954 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1052588004955 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1052588004956 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1052588004957 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1052588004958 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1052588004959 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1052588004960 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1052588004961 MgtE intracellular N domain; Region: MgtE_N; smart00924 1052588004962 FliG C-terminal domain; Region: FliG_C; pfam01706 1052588004963 flagellar assembly protein H; Validated; Region: fliH; PRK06669 1052588004964 Flagellar assembly protein FliH; Region: FliH; pfam02108 1052588004965 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1052588004966 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1052588004967 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1052588004968 Walker A motif/ATP binding site; other site 1052588004969 Walker B motif; other site 1052588004970 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1052588004971 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1052588004972 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1052588004973 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1052588004974 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1052588004975 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1052588004976 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1052588004977 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1052588004978 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1052588004979 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1052588004980 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 1052588004981 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 1052588004982 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1052588004983 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1052588004984 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1052588004985 flagellar motor switch protein; Validated; Region: PRK08119 1052588004986 CheC-like family; Region: CheC; pfam04509 1052588004987 CheC-like family; Region: CheC; pfam04509 1052588004988 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1052588004989 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588004990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588004991 active site 1052588004992 phosphorylation site [posttranslational modification] 1052588004993 intermolecular recognition site; other site 1052588004994 dimerization interface [polypeptide binding]; other site 1052588004995 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 1052588004996 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1052588004997 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1052588004998 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1052588004999 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1052588005000 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1052588005001 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1052588005002 FHIPEP family; Region: FHIPEP; pfam00771 1052588005003 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1052588005004 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1052588005005 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1052588005006 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1052588005007 P-loop; other site 1052588005008 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1052588005009 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1052588005010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588005011 active site 1052588005012 phosphorylation site [posttranslational modification] 1052588005013 intermolecular recognition site; other site 1052588005014 dimerization interface [polypeptide binding]; other site 1052588005015 CheB methylesterase; Region: CheB_methylest; pfam01339 1052588005016 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1052588005017 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1052588005018 putative binding surface; other site 1052588005019 active site 1052588005020 P2 response regulator binding domain; Region: P2; pfam07194 1052588005021 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1052588005022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588005023 ATP binding site [chemical binding]; other site 1052588005024 Mg2+ binding site [ion binding]; other site 1052588005025 G-X-G motif; other site 1052588005026 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1052588005027 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1052588005028 putative CheA interaction surface; other site 1052588005029 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1052588005030 CheC-like family; Region: CheC; pfam04509 1052588005031 CheC-like family; Region: CheC; pfam04509 1052588005032 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1052588005033 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1052588005034 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588005035 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052588005036 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588005037 DNA binding residues [nucleotide binding] 1052588005038 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1052588005039 rRNA interaction site [nucleotide binding]; other site 1052588005040 S8 interaction site; other site 1052588005041 putative laminin-1 binding site; other site 1052588005042 elongation factor Ts; Provisional; Region: tsf; PRK09377 1052588005043 UBA/TS-N domain; Region: UBA; pfam00627 1052588005044 Elongation factor TS; Region: EF_TS; pfam00889 1052588005045 Elongation factor TS; Region: EF_TS; pfam00889 1052588005046 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1052588005047 putative nucleotide binding site [chemical binding]; other site 1052588005048 uridine monophosphate binding site [chemical binding]; other site 1052588005049 homohexameric interface [polypeptide binding]; other site 1052588005050 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1052588005051 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1052588005052 hinge region; other site 1052588005053 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1052588005054 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1052588005055 catalytic residue [active] 1052588005056 putative FPP diphosphate binding site; other site 1052588005057 putative FPP binding hydrophobic cleft; other site 1052588005058 dimer interface [polypeptide binding]; other site 1052588005059 putative IPP diphosphate binding site; other site 1052588005060 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1052588005061 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1052588005062 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1052588005063 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1052588005064 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1052588005065 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1052588005066 RIP metalloprotease RseP; Region: TIGR00054 1052588005067 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1052588005068 active site 1052588005069 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1052588005070 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1052588005071 protein binding site [polypeptide binding]; other site 1052588005072 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1052588005073 putative substrate binding region [chemical binding]; other site 1052588005074 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1052588005075 motif 3; other site 1052588005076 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1052588005077 anticodon binding site; other site 1052588005078 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1052588005079 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1052588005080 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1052588005081 generic binding surface II; other site 1052588005082 generic binding surface I; other site 1052588005083 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1052588005084 active site 1052588005085 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1052588005086 active site 1052588005087 catalytic site [active] 1052588005088 substrate binding site [chemical binding]; other site 1052588005089 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1052588005090 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1052588005091 Sm and related proteins; Region: Sm_like; cl00259 1052588005092 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1052588005093 putative oligomer interface [polypeptide binding]; other site 1052588005094 putative RNA binding site [nucleotide binding]; other site 1052588005095 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1052588005096 NusA N-terminal domain; Region: NusA_N; pfam08529 1052588005097 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1052588005098 RNA binding site [nucleotide binding]; other site 1052588005099 homodimer interface [polypeptide binding]; other site 1052588005100 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1052588005101 G-X-X-G motif; other site 1052588005102 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1052588005103 G-X-X-G motif; other site 1052588005104 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1052588005105 putative RNA binding cleft [nucleotide binding]; other site 1052588005106 hypothetical protein; Provisional; Region: PRK07714 1052588005107 Translation-initiation factor 2; Region: IF-2; pfam11987 1052588005108 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1052588005109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1052588005110 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1052588005111 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1052588005112 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1052588005113 RNA binding site [nucleotide binding]; other site 1052588005114 active site 1052588005115 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1052588005116 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 1052588005117 active site 1052588005118 Riboflavin kinase; Region: Flavokinase; smart00904 1052588005119 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1052588005120 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1052588005121 RNase E interface [polypeptide binding]; other site 1052588005122 trimer interface [polypeptide binding]; other site 1052588005123 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1052588005124 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1052588005125 RNase E interface [polypeptide binding]; other site 1052588005126 trimer interface [polypeptide binding]; other site 1052588005127 active site 1052588005128 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1052588005129 putative nucleic acid binding region [nucleotide binding]; other site 1052588005130 G-X-X-G motif; other site 1052588005131 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1052588005132 RNA binding site [nucleotide binding]; other site 1052588005133 domain interface; other site 1052588005134 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1052588005135 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1052588005136 NodB motif; other site 1052588005137 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052588005138 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052588005139 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052588005140 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1052588005141 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1052588005142 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1052588005143 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 1052588005144 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1052588005145 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1052588005146 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1052588005147 aspartate kinase I; Reviewed; Region: PRK08210 1052588005148 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1052588005149 nucleotide binding site [chemical binding]; other site 1052588005150 substrate binding site [chemical binding]; other site 1052588005151 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1052588005152 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1052588005153 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1052588005154 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1052588005155 dimer interface [polypeptide binding]; other site 1052588005156 active site 1052588005157 catalytic residue [active] 1052588005158 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1052588005159 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052588005160 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1052588005161 Clp protease; Region: CLP_protease; pfam00574 1052588005162 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1052588005163 active site 1052588005164 YlzJ-like protein; Region: YlzJ; pfam14035 1052588005165 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1052588005166 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1052588005167 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052588005168 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1052588005169 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052588005170 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588005171 DNA-binding site [nucleotide binding]; DNA binding site 1052588005172 UTRA domain; Region: UTRA; pfam07702 1052588005173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588005174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588005175 putative substrate translocation pore; other site 1052588005176 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052588005177 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052588005178 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052588005179 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052588005180 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052588005181 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1052588005182 classical (c) SDRs; Region: SDR_c; cd05233 1052588005183 NAD(P) binding site [chemical binding]; other site 1052588005184 active site 1052588005185 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1052588005186 ACT domain; Region: ACT; pfam01842 1052588005187 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1052588005188 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1052588005189 Helix-turn-helix domain; Region: HTH_25; pfam13413 1052588005190 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1052588005191 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1052588005192 competence damage-inducible protein A; Provisional; Region: PRK00549 1052588005193 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1052588005194 putative MPT binding site; other site 1052588005195 competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199 1052588005196 recombinase A; Provisional; Region: recA; PRK09354 1052588005197 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1052588005198 hexamer interface [polypeptide binding]; other site 1052588005199 Walker A motif; other site 1052588005200 ATP binding site [chemical binding]; other site 1052588005201 Walker B motif; other site 1052588005202 Beta-lactamase; Region: Beta-lactamase; pfam00144 1052588005203 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052588005204 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1052588005205 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1052588005206 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052588005207 Zn2+ binding site [ion binding]; other site 1052588005208 Mg2+ binding site [ion binding]; other site 1052588005209 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1052588005210 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052588005211 putative active site [active] 1052588005212 metal binding site [ion binding]; metal-binding site 1052588005213 homodimer binding site [polypeptide binding]; other site 1052588005214 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1052588005215 Threonine dehydrogenase; Region: TDH; cd05281 1052588005216 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 1052588005217 structural Zn binding site [ion binding]; other site 1052588005218 catalytic Zn binding site [ion binding]; other site 1052588005219 tetramer interface [polypeptide binding]; other site 1052588005220 NADP binding site [chemical binding]; other site 1052588005221 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1052588005222 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1052588005223 substrate-cofactor binding pocket; other site 1052588005224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588005225 catalytic residue [active] 1052588005226 TRAM domain; Region: TRAM; pfam01938 1052588005227 Predicted membrane protein [Function unknown]; Region: COG4550 1052588005228 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1052588005229 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1052588005230 MutS domain I; Region: MutS_I; pfam01624 1052588005231 MutS domain II; Region: MutS_II; pfam05188 1052588005232 MutS domain III; Region: MutS_III; pfam05192 1052588005233 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1052588005234 Walker A/P-loop; other site 1052588005235 ATP binding site [chemical binding]; other site 1052588005236 Q-loop/lid; other site 1052588005237 ABC transporter signature motif; other site 1052588005238 Walker B; other site 1052588005239 D-loop; other site 1052588005240 H-loop/switch region; other site 1052588005241 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1052588005242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588005243 ATP binding site [chemical binding]; other site 1052588005244 Mg2+ binding site [ion binding]; other site 1052588005245 G-X-G motif; other site 1052588005246 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1052588005247 ATP binding site [chemical binding]; other site 1052588005248 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1052588005249 Regulatory protein YrvL; Region: YrvL; pfam14184 1052588005250 transcriptional regulator BetI; Validated; Region: PRK00767 1052588005251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588005252 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1052588005253 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588005254 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1052588005255 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052588005256 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052588005257 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1052588005258 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052588005259 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1052588005260 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1052588005261 FMN binding site [chemical binding]; other site 1052588005262 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1052588005263 substrate binding site [chemical binding]; other site 1052588005264 putative catalytic residue [active] 1052588005265 acyl carrier protein; Validated; Region: PRK07117 1052588005266 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1052588005267 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1052588005268 dimer interface [polypeptide binding]; other site 1052588005269 active site 1052588005270 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1052588005271 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1052588005272 dimer interface [polypeptide binding]; other site 1052588005273 active site 1052588005274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588005275 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052588005276 substrate binding site [chemical binding]; other site 1052588005277 oxyanion hole (OAH) forming residues; other site 1052588005278 trimer interface [polypeptide binding]; other site 1052588005279 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052588005280 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588005281 substrate binding site [chemical binding]; other site 1052588005282 oxyanion hole (OAH) forming residues; other site 1052588005283 trimer interface [polypeptide binding]; other site 1052588005284 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 1052588005285 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1052588005286 acyl-activating enzyme (AAE) consensus motif; other site 1052588005287 putative AMP binding site [chemical binding]; other site 1052588005288 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005289 Condensation domain; Region: Condensation; pfam00668 1052588005290 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005291 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005292 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1052588005293 acyl-activating enzyme (AAE) consensus motif; other site 1052588005294 AMP binding site [chemical binding]; other site 1052588005295 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005296 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005297 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005298 active site 1052588005299 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005300 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005301 KR domain; Region: KR; pfam08659 1052588005302 putative NADP binding site [chemical binding]; other site 1052588005303 active site 1052588005304 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005305 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052588005306 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005307 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005308 active site 1052588005309 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005310 putative NADP binding site [chemical binding]; other site 1052588005311 active site 1052588005312 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005313 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005314 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052588005315 active site 1052588005316 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005317 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005318 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005319 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005320 active site 1052588005321 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005322 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005323 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052588005324 putative NADP binding site [chemical binding]; other site 1052588005325 active site 1052588005326 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005327 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005328 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052588005329 active site 1052588005330 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052588005331 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052588005332 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005333 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005334 active site 1052588005335 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005336 putative NADP binding site [chemical binding]; other site 1052588005337 active site 1052588005338 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005339 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005340 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052588005341 active site 1052588005342 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005343 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052588005344 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005345 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005346 active site 1052588005347 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005348 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005349 putative NADP binding site [chemical binding]; other site 1052588005350 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052588005351 active site 1052588005352 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1052588005353 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005354 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005355 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005356 active site 1052588005357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588005358 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005359 putative NADP binding site [chemical binding]; other site 1052588005360 active site 1052588005361 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005362 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005363 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052588005364 active site 1052588005365 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005366 Condensation domain; Region: Condensation; pfam00668 1052588005367 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005368 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005369 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052588005370 acyl-activating enzyme (AAE) consensus motif; other site 1052588005371 AMP binding site [chemical binding]; other site 1052588005372 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005373 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005374 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005375 active site 1052588005376 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005377 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005378 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052588005379 putative NADP binding site [chemical binding]; other site 1052588005380 active site 1052588005381 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052588005382 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005383 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005384 active site 1052588005385 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005386 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005387 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052588005388 putative NADP binding site [chemical binding]; other site 1052588005389 active site 1052588005390 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052588005391 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005392 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005393 active site 1052588005394 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005395 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005396 putative NADP binding site [chemical binding]; other site 1052588005397 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052588005398 active site 1052588005399 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588005401 S-adenosylmethionine binding site [chemical binding]; other site 1052588005402 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052588005403 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005404 active site 1052588005405 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005406 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005407 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052588005408 active site 1052588005409 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005410 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1052588005411 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052588005412 Cytochrome P450; Region: p450; cl12078 1052588005413 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052588005414 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1052588005415 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1052588005416 active site 1052588005417 catalytic triad [active] 1052588005418 WYL domain; Region: WYL; cl14852 1052588005419 Phage-related replication protein [General function prediction only]; Region: COG4195 1052588005420 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1052588005421 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052588005422 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1052588005423 YmaF family; Region: YmaF; pfam12788 1052588005424 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1052588005425 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1052588005426 bacterial Hfq-like; Region: Hfq; cd01716 1052588005427 hexamer interface [polypeptide binding]; other site 1052588005428 Sm1 motif; other site 1052588005429 RNA binding site [nucleotide binding]; other site 1052588005430 Sm2 motif; other site 1052588005431 YmzC-like protein; Region: YmzC; pfam14157 1052588005432 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1052588005433 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1052588005434 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1052588005435 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1052588005436 active site 1052588005437 dimer interface [polypeptide binding]; other site 1052588005438 catalytic residues [active] 1052588005439 effector binding site; other site 1052588005440 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1052588005441 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1052588005442 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1052588005443 dimer interface [polypeptide binding]; other site 1052588005444 putative radical transfer pathway; other site 1052588005445 diiron center [ion binding]; other site 1052588005446 tyrosyl radical; other site 1052588005447 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1052588005448 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1052588005449 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052588005450 active site 1052588005451 metal binding site [ion binding]; metal-binding site 1052588005452 Sporulation related domain; Region: SPOR; pfam05036 1052588005453 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1052588005454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588005455 Walker A motif; other site 1052588005456 ATP binding site [chemical binding]; other site 1052588005457 Walker B motif; other site 1052588005458 arginine finger; other site 1052588005459 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1052588005460 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1052588005461 HflX GTPase family; Region: HflX; cd01878 1052588005462 G1 box; other site 1052588005463 GTP/Mg2+ binding site [chemical binding]; other site 1052588005464 Switch I region; other site 1052588005465 G2 box; other site 1052588005466 G3 box; other site 1052588005467 Switch II region; other site 1052588005468 G4 box; other site 1052588005469 G5 box; other site 1052588005470 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1052588005471 Aluminium resistance protein; Region: Alum_res; pfam06838 1052588005472 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1052588005473 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052588005474 DNA binding residues [nucleotide binding] 1052588005475 putative dimer interface [polypeptide binding]; other site 1052588005476 glutamine synthetase, type I; Region: GlnA; TIGR00653 1052588005477 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1052588005478 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1052588005479 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052588005480 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1052588005481 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1052588005482 active site 1052588005483 catalytic site [active] 1052588005484 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1052588005485 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1052588005486 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1052588005487 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1052588005488 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052588005489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588005490 Coenzyme A binding pocket [chemical binding]; other site 1052588005491 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1052588005492 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1052588005493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588005494 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1052588005495 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1052588005496 inhibitor binding site; inhibition site 1052588005497 active site 1052588005498 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1052588005499 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1052588005500 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052588005501 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052588005502 nucleotide binding site [chemical binding]; other site 1052588005503 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1052588005504 xylose isomerase; Provisional; Region: PRK05474 1052588005505 xylose isomerase; Region: xylose_isom_A; TIGR02630 1052588005506 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1052588005507 N- and C-terminal domain interface [polypeptide binding]; other site 1052588005508 D-xylulose kinase; Region: XylB; TIGR01312 1052588005509 active site 1052588005510 MgATP binding site [chemical binding]; other site 1052588005511 catalytic site [active] 1052588005512 metal binding site [ion binding]; metal-binding site 1052588005513 xylulose binding site [chemical binding]; other site 1052588005514 homodimer interface [polypeptide binding]; other site 1052588005515 Staphylococcal nuclease homologues; Region: SNc; smart00318 1052588005516 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1052588005517 Catalytic site; other site 1052588005518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588005519 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052588005520 putative substrate translocation pore; other site 1052588005521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588005522 alanine racemase; Region: alr; TIGR00492 1052588005523 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1052588005524 active site 1052588005525 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052588005526 dimer interface [polypeptide binding]; other site 1052588005527 substrate binding site [chemical binding]; other site 1052588005528 catalytic residues [active] 1052588005529 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1052588005530 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1052588005531 trimer interface [polypeptide binding]; other site 1052588005532 active site 1052588005533 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1052588005534 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1052588005535 dimerization interface [polypeptide binding]; other site 1052588005536 active site 1052588005537 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1052588005538 putative binding site; other site 1052588005539 putative dimer interface [polypeptide binding]; other site 1052588005540 YoqO-like protein; Region: YoqO; pfam14037 1052588005541 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1052588005542 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1052588005543 putative hydrophobic ligand binding site [chemical binding]; other site 1052588005544 Spore germination protein; Region: Spore_permease; pfam03845 1052588005545 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052588005546 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052588005547 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1052588005548 YndJ-like protein; Region: YndJ; pfam14158 1052588005549 Phage-related replication protein [General function prediction only]; Region: COG4195 1052588005550 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1052588005551 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1052588005552 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 1052588005553 putative active site [active] 1052588005554 putative Mg binding site [ion binding]; other site 1052588005555 LexA repressor; Validated; Region: PRK00215 1052588005556 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588005557 putative DNA binding site [nucleotide binding]; other site 1052588005558 putative Zn2+ binding site [ion binding]; other site 1052588005559 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1052588005560 Catalytic site [active] 1052588005561 cell division suppressor protein YneA; Provisional; Region: PRK14125 1052588005562 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588005563 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1052588005564 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1052588005565 catalytic residues [active] 1052588005566 catalytic nucleophile [active] 1052588005567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1052588005568 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1052588005569 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1052588005570 TPP-binding site [chemical binding]; other site 1052588005571 dimer interface [polypeptide binding]; other site 1052588005572 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1052588005573 PYR/PP interface [polypeptide binding]; other site 1052588005574 dimer interface [polypeptide binding]; other site 1052588005575 TPP binding site [chemical binding]; other site 1052588005576 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052588005577 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1052588005578 hypothetical protein; Provisional; Region: PRK01844 1052588005579 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052588005580 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1052588005581 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1052588005582 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588005583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588005584 active site 1052588005585 phosphorylation site [posttranslational modification] 1052588005586 intermolecular recognition site; other site 1052588005587 dimerization interface [polypeptide binding]; other site 1052588005588 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1052588005589 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1052588005590 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1052588005591 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1052588005592 putative dimer interface [polypeptide binding]; other site 1052588005593 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1052588005594 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1052588005595 aconitate hydratase; Validated; Region: PRK09277 1052588005596 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1052588005597 substrate binding site [chemical binding]; other site 1052588005598 ligand binding site [chemical binding]; other site 1052588005599 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1052588005600 substrate binding site [chemical binding]; other site 1052588005601 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1052588005602 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052588005603 catalytic residues [active] 1052588005604 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1052588005605 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1052588005606 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1052588005607 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1052588005608 active site 1052588005609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1052588005610 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1052588005611 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1052588005612 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1052588005613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588005614 ATP binding site [chemical binding]; other site 1052588005615 Mg2+ binding site [ion binding]; other site 1052588005616 G-X-G motif; other site 1052588005617 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1052588005618 anchoring element; other site 1052588005619 dimer interface [polypeptide binding]; other site 1052588005620 ATP binding site [chemical binding]; other site 1052588005621 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1052588005622 active site 1052588005623 putative metal-binding site [ion binding]; other site 1052588005624 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1052588005625 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1052588005626 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1052588005627 CAP-like domain; other site 1052588005628 active site 1052588005629 primary dimer interface [polypeptide binding]; other site 1052588005630 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588005631 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588005632 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588005633 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588005634 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052588005635 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1052588005636 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1052588005637 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1052588005638 Cellulose binding domain; Region: CBM_3; pfam00942 1052588005639 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1052588005640 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1052588005641 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1052588005642 substrate binding site [chemical binding]; other site 1052588005643 active site 1052588005644 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1052588005645 metal binding site [ion binding]; metal-binding site 1052588005646 ligand binding site [chemical binding]; other site 1052588005647 Predicted membrane protein [Function unknown]; Region: COG2246 1052588005648 GtrA-like protein; Region: GtrA; pfam04138 1052588005649 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052588005650 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1052588005651 active site 1052588005652 tetramer interface; other site 1052588005653 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1052588005654 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052588005655 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1052588005656 DHH family; Region: DHH; pfam01368 1052588005657 DHHA1 domain; Region: DHHA1; pfam02272 1052588005658 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1052588005659 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1052588005660 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1052588005661 enoyl-CoA hydratase; Provisional; Region: PRK07657 1052588005662 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588005663 substrate binding site [chemical binding]; other site 1052588005664 oxyanion hole (OAH) forming residues; other site 1052588005665 trimer interface [polypeptide binding]; other site 1052588005666 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1052588005667 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1052588005668 active site 1052588005669 catalytic residues [active] 1052588005670 metal binding site [ion binding]; metal-binding site 1052588005671 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1052588005672 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052588005673 carboxyltransferase (CT) interaction site; other site 1052588005674 biotinylation site [posttranslational modification]; other site 1052588005675 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1052588005676 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588005677 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1052588005678 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1052588005679 AMP-binding domain protein; Validated; Region: PRK08315 1052588005680 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052588005681 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1052588005682 acyl-activating enzyme (AAE) consensus motif; other site 1052588005683 putative AMP binding site [chemical binding]; other site 1052588005684 putative active site [active] 1052588005685 putative CoA binding site [chemical binding]; other site 1052588005686 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052588005687 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1052588005688 active site 1052588005689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588005690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588005691 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052588005692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052588005693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1052588005694 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1052588005695 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1052588005696 Condensation domain; Region: Condensation; pfam00668 1052588005697 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005698 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052588005699 acyl-activating enzyme (AAE) consensus motif; other site 1052588005700 AMP binding site [chemical binding]; other site 1052588005701 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005702 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1052588005703 Condensation domain; Region: Condensation; pfam00668 1052588005704 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005705 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052588005706 acyl-activating enzyme (AAE) consensus motif; other site 1052588005707 AMP binding site [chemical binding]; other site 1052588005708 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005709 Condensation domain; Region: Condensation; pfam00668 1052588005710 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005711 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005712 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052588005713 acyl-activating enzyme (AAE) consensus motif; other site 1052588005714 AMP binding site [chemical binding]; other site 1052588005715 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005716 Condensation domain; Region: Condensation; pfam00668 1052588005717 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005718 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005719 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052588005720 acyl-activating enzyme (AAE) consensus motif; other site 1052588005721 AMP binding site [chemical binding]; other site 1052588005722 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005723 Condensation domain; Region: Condensation; pfam00668 1052588005724 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052588005725 Condensation domain; Region: Condensation; pfam00668 1052588005726 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005727 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052588005728 acyl-activating enzyme (AAE) consensus motif; other site 1052588005729 AMP binding site [chemical binding]; other site 1052588005730 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005731 Condensation domain; Region: Condensation; pfam00668 1052588005732 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005733 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005734 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052588005735 acyl-activating enzyme (AAE) consensus motif; other site 1052588005736 AMP binding site [chemical binding]; other site 1052588005737 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005738 Condensation domain; Region: Condensation; pfam00668 1052588005739 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052588005740 Condensation domain; Region: Condensation; pfam00668 1052588005741 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005742 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052588005743 acyl-activating enzyme (AAE) consensus motif; other site 1052588005744 AMP binding site [chemical binding]; other site 1052588005745 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005746 Condensation domain; Region: Condensation; pfam00668 1052588005747 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005748 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005749 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052588005750 acyl-activating enzyme (AAE) consensus motif; other site 1052588005751 AMP binding site [chemical binding]; other site 1052588005752 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005753 Condensation domain; Region: Condensation; pfam00668 1052588005754 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005755 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052588005756 Condensation domain; Region: Condensation; pfam00668 1052588005757 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005758 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005759 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052588005760 acyl-activating enzyme (AAE) consensus motif; other site 1052588005761 AMP binding site [chemical binding]; other site 1052588005762 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005763 Condensation domain; Region: Condensation; pfam00668 1052588005764 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005765 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005766 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052588005767 acyl-activating enzyme (AAE) consensus motif; other site 1052588005768 AMP binding site [chemical binding]; other site 1052588005769 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588005770 Condensation domain; Region: Condensation; pfam00668 1052588005771 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005772 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052588005773 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1052588005774 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1052588005775 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1052588005776 active site 1052588005777 catalytic residues [active] 1052588005778 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052588005779 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1052588005780 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1052588005781 Int/Topo IB signature motif; other site 1052588005782 Helix-turn-helix domain; Region: HTH_17; cl17695 1052588005783 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1052588005784 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1052588005785 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588005786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588005787 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1052588005788 putative dimerization interface [polypeptide binding]; other site 1052588005789 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1052588005790 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1052588005791 NAD(P) binding site [chemical binding]; other site 1052588005792 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1052588005793 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1052588005794 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1052588005795 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1052588005796 active site 1052588005797 dimer interface [polypeptide binding]; other site 1052588005798 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1052588005799 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1052588005800 active site 1052588005801 FMN binding site [chemical binding]; other site 1052588005802 substrate binding site [chemical binding]; other site 1052588005803 3Fe-4S cluster binding site [ion binding]; other site 1052588005804 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1052588005805 domain interface; other site 1052588005806 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588005807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588005808 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1052588005809 putative dimerization interface [polypeptide binding]; other site 1052588005810 gamma-glutamyl kinase; Provisional; Region: PRK13402 1052588005811 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1052588005812 nucleotide binding site [chemical binding]; other site 1052588005813 homotetrameric interface [polypeptide binding]; other site 1052588005814 putative phosphate binding site [ion binding]; other site 1052588005815 putative allosteric binding site; other site 1052588005816 PUA domain; Region: PUA; pfam01472 1052588005817 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1052588005818 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1052588005819 Replication terminator protein; Region: RTP; pfam02334 1052588005820 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1052588005821 classical (c) SDRs; Region: SDR_c; cd05233 1052588005822 NAD(P) binding site [chemical binding]; other site 1052588005823 active site 1052588005824 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1052588005825 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052588005826 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052588005827 polyol permease family; Region: 2A0118; TIGR00897 1052588005828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588005829 putative substrate translocation pore; other site 1052588005830 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1052588005831 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 1052588005832 putative N- and C-terminal domain interface [polypeptide binding]; other site 1052588005833 putative active site [active] 1052588005834 putative MgATP binding site [chemical binding]; other site 1052588005835 catalytic site [active] 1052588005836 metal binding site [ion binding]; metal-binding site 1052588005837 carbohydrate binding site [chemical binding]; other site 1052588005838 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1052588005839 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1052588005840 putative ligand binding site [chemical binding]; other site 1052588005841 putative NAD binding site [chemical binding]; other site 1052588005842 catalytic site [active] 1052588005843 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1052588005844 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1052588005845 putative [4Fe-4S] binding site [ion binding]; other site 1052588005846 putative molybdopterin cofactor binding site [chemical binding]; other site 1052588005847 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1052588005848 putative molybdopterin cofactor binding site; other site 1052588005849 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588005850 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052588005851 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052588005852 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052588005853 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1052588005854 Metal-binding active site; metal-binding site 1052588005855 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588005856 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588005857 DNA binding site [nucleotide binding] 1052588005858 domain linker motif; other site 1052588005859 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052588005860 dimerization interface [polypeptide binding]; other site 1052588005861 ligand binding site [chemical binding]; other site 1052588005862 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1052588005863 CHASE3 domain; Region: CHASE3; cl05000 1052588005864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588005865 dimerization interface [polypeptide binding]; other site 1052588005866 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052588005867 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588005868 dimer interface [polypeptide binding]; other site 1052588005869 putative CheW interface [polypeptide binding]; other site 1052588005870 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1052588005871 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1052588005872 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 1052588005873 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1052588005874 Predicted membrane protein [Function unknown]; Region: COG3619 1052588005875 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1052588005876 Amb_all domain; Region: Amb_all; smart00656 1052588005877 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1052588005878 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1052588005879 Cupin; Region: Cupin_1; smart00835 1052588005880 Cupin; Region: Cupin_1; smart00835 1052588005881 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1052588005882 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1052588005883 VanW like protein; Region: VanW; pfam04294 1052588005884 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1052588005885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588005886 salt bridge; other site 1052588005887 non-specific DNA binding site [nucleotide binding]; other site 1052588005888 sequence-specific DNA binding site [nucleotide binding]; other site 1052588005889 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 1052588005890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588005891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588005892 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588005893 dimerization interface [polypeptide binding]; other site 1052588005894 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052588005895 EamA-like transporter family; Region: EamA; pfam00892 1052588005896 EamA-like transporter family; Region: EamA; pfam00892 1052588005897 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1052588005898 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1052588005899 conserved cys residue [active] 1052588005900 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1052588005901 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1052588005902 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 1052588005903 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1052588005904 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1052588005905 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1052588005906 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1052588005907 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1052588005908 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052588005909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588005910 non-specific DNA binding site [nucleotide binding]; other site 1052588005911 salt bridge; other site 1052588005912 sequence-specific DNA binding site [nucleotide binding]; other site 1052588005913 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1052588005914 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1052588005915 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1052588005916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588005917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588005918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588005919 dimerization interface [polypeptide binding]; other site 1052588005920 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1052588005921 putative deacylase active site [active] 1052588005922 EamA-like transporter family; Region: EamA; pfam00892 1052588005923 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052588005924 EamA-like transporter family; Region: EamA; pfam00892 1052588005925 Bacteriophage holin; Region: Phage_holin_1; cl02344 1052588005926 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588005927 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588005928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588005929 TPR motif; other site 1052588005930 binding surface 1052588005931 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1052588005932 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1052588005933 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1052588005934 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1052588005935 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1052588005936 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1052588005937 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1052588005938 dimer interface [polypeptide binding]; other site 1052588005939 putative tRNA-binding site [nucleotide binding]; other site 1052588005940 Cupin domain; Region: Cupin_2; pfam07883 1052588005941 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588005942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588005943 Coenzyme A binding pocket [chemical binding]; other site 1052588005944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588005945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588005946 WHG domain; Region: WHG; pfam13305 1052588005947 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1052588005948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052588005949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1052588005950 Predicted transcriptional regulator [Transcription]; Region: COG2378 1052588005951 HTH domain; Region: HTH_11; pfam08279 1052588005952 WYL domain; Region: WYL; pfam13280 1052588005953 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588005954 dimerization interface [polypeptide binding]; other site 1052588005955 putative DNA binding site [nucleotide binding]; other site 1052588005956 putative Zn2+ binding site [ion binding]; other site 1052588005957 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1052588005958 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1052588005959 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052588005960 catalytic residue [active] 1052588005961 Predicted membrane protein [Function unknown]; Region: COG2322 1052588005962 Protein required for attachment to host cells; Region: Host_attach; cl02398 1052588005963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052588005964 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1052588005965 putative dimer interface [polypeptide binding]; other site 1052588005966 catalytic triad [active] 1052588005967 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1052588005968 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1052588005969 putative di-iron ligands [ion binding]; other site 1052588005970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588005971 Histidine kinase; Region: HisKA_3; pfam07730 1052588005972 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1052588005973 ATP binding site [chemical binding]; other site 1052588005974 Mg2+ binding site [ion binding]; other site 1052588005975 G-X-G motif; other site 1052588005976 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588005977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588005978 active site 1052588005979 phosphorylation site [posttranslational modification] 1052588005980 intermolecular recognition site; other site 1052588005981 dimerization interface [polypeptide binding]; other site 1052588005982 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588005983 DNA binding residues [nucleotide binding] 1052588005984 dimerization interface [polypeptide binding]; other site 1052588005985 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588005986 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588005987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1052588005988 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1052588005989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588005990 ATP binding site [chemical binding]; other site 1052588005991 putative Mg++ binding site [ion binding]; other site 1052588005992 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588005993 nucleotide binding region [chemical binding]; other site 1052588005994 ATP-binding site [chemical binding]; other site 1052588005995 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1052588005996 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1052588005997 azoreductase; Provisional; Region: PRK13556 1052588005998 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1052588005999 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1052588006000 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1052588006001 putative dimer interface [polypeptide binding]; other site 1052588006002 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1052588006003 pentamer interface [polypeptide binding]; other site 1052588006004 dodecaamer interface [polypeptide binding]; other site 1052588006005 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1052588006006 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052588006007 NAD(P) binding site [chemical binding]; other site 1052588006008 catalytic residues [active] 1052588006009 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1052588006010 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1052588006011 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1052588006012 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1052588006013 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1052588006014 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1052588006015 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1052588006016 Na2 binding site [ion binding]; other site 1052588006017 putative substrate binding site 1 [chemical binding]; other site 1052588006018 Na binding site 1 [ion binding]; other site 1052588006019 putative substrate binding site 2 [chemical binding]; other site 1052588006020 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1052588006021 Sodium Bile acid symporter family; Region: SBF; pfam01758 1052588006022 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1052588006023 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052588006024 E3 interaction surface; other site 1052588006025 lipoyl attachment site [posttranslational modification]; other site 1052588006026 e3 binding domain; Region: E3_binding; pfam02817 1052588006027 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1052588006028 2-oxoglutarate dehydrogenase, E1 component; Region: 2oxo_dh_E1; TIGR00239 1052588006029 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1052588006030 TPP-binding site [chemical binding]; other site 1052588006031 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1052588006032 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1052588006033 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1052588006034 metal ion-dependent adhesion site (MIDAS); other site 1052588006035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588006036 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052588006037 Walker A motif; other site 1052588006038 ATP binding site [chemical binding]; other site 1052588006039 Walker B motif; other site 1052588006040 arginine finger; other site 1052588006041 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1052588006042 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1052588006043 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1052588006044 E-class dimer interface [polypeptide binding]; other site 1052588006045 P-class dimer interface [polypeptide binding]; other site 1052588006046 active site 1052588006047 Cu2+ binding site [ion binding]; other site 1052588006048 Zn2+ binding site [ion binding]; other site 1052588006049 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588006050 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588006051 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588006052 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1052588006053 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588006054 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052588006055 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052588006056 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052588006057 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1052588006058 active site 1052588006059 TDP-binding site; other site 1052588006060 acceptor substrate-binding pocket; other site 1052588006061 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1052588006062 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1052588006063 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052588006064 multidrug efflux protein; Reviewed; Region: PRK01766 1052588006065 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1052588006066 cation binding site [ion binding]; other site 1052588006067 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588006068 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1052588006069 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1052588006070 rarD protein; Region: rarD; TIGR00688 1052588006071 EamA-like transporter family; Region: EamA; pfam00892 1052588006072 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1052588006073 GntP family permease; Region: GntP_permease; pfam02447 1052588006074 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1052588006075 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1052588006076 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052588006077 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588006078 dimerization interface [polypeptide binding]; other site 1052588006079 putative DNA binding site [nucleotide binding]; other site 1052588006080 putative Zn2+ binding site [ion binding]; other site 1052588006081 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052588006082 dimer interface [polypeptide binding]; other site 1052588006083 FMN binding site [chemical binding]; other site 1052588006084 Predicted esterase [General function prediction only]; Region: COG0400 1052588006085 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052588006086 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588006087 Zn binding site [ion binding]; other site 1052588006088 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052588006089 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588006090 Zn binding site [ion binding]; other site 1052588006091 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1052588006092 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1052588006093 Na binding site [ion binding]; other site 1052588006094 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1052588006095 C-terminal peptidase (prc); Region: prc; TIGR00225 1052588006096 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1052588006097 protein binding site [polypeptide binding]; other site 1052588006098 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1052588006099 Catalytic dyad [active] 1052588006100 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052588006101 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052588006102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588006103 S-adenosylmethionine binding site [chemical binding]; other site 1052588006104 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1052588006105 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1052588006106 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1052588006107 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1052588006108 YodL-like; Region: YodL; pfam14191 1052588006109 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1052588006110 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1052588006111 active site 1052588006112 YozD-like protein; Region: YozD; pfam14162 1052588006113 hypothetical protein; Provisional; Region: PRK13672 1052588006114 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1052588006115 toxin interface [polypeptide binding]; other site 1052588006116 Zn binding site [ion binding]; other site 1052588006117 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1052588006118 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588006119 FeS/SAM binding site; other site 1052588006120 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1052588006121 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1052588006122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588006123 Coenzyme A binding pocket [chemical binding]; other site 1052588006124 acetylornithine deacetylase; Validated; Region: PRK06915 1052588006125 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1052588006126 metal binding site [ion binding]; metal-binding site 1052588006127 dimer interface [polypeptide binding]; other site 1052588006128 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1052588006129 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1052588006130 hypothetical protein; Provisional; Region: PRK06917 1052588006131 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588006132 inhibitor-cofactor binding pocket; inhibition site 1052588006133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588006134 catalytic residue [active] 1052588006135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588006136 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052588006137 Coenzyme A binding pocket [chemical binding]; other site 1052588006138 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052588006139 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588006140 active site 1052588006141 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1052588006142 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1052588006143 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1052588006144 Phytase; Region: Phytase; cl17685 1052588006145 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1052588006146 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1052588006147 NAD(P) binding site [chemical binding]; other site 1052588006148 homodimer interface [polypeptide binding]; other site 1052588006149 substrate binding site [chemical binding]; other site 1052588006150 active site 1052588006151 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1052588006152 SelR domain; Region: SelR; pfam01641 1052588006153 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1052588006154 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588006155 MarR family; Region: MarR; pfam01047 1052588006156 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052588006157 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1052588006158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 1052588006159 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1052588006160 active site 1052588006161 catalytic triad [active] 1052588006162 oxyanion hole [active] 1052588006163 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1052588006164 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1052588006165 Cu(I) binding site [ion binding]; other site 1052588006166 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1052588006167 threonine dehydratase; Validated; Region: PRK08639 1052588006168 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1052588006169 tetramer interface [polypeptide binding]; other site 1052588006170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588006171 catalytic residue [active] 1052588006172 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1052588006173 putative Ile/Val binding site [chemical binding]; other site 1052588006174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588006175 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052588006176 Walker A motif; other site 1052588006177 ATP binding site [chemical binding]; other site 1052588006178 Walker B motif; other site 1052588006179 arginine finger; other site 1052588006180 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1052588006181 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1052588006182 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1052588006183 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1052588006184 putative acyl-acceptor binding pocket; other site 1052588006185 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1052588006186 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1052588006187 folate binding site [chemical binding]; other site 1052588006188 NADP+ binding site [chemical binding]; other site 1052588006189 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1052588006190 tetramer interfaces [polypeptide binding]; other site 1052588006191 binuclear metal-binding site [ion binding]; other site 1052588006192 YpjP-like protein; Region: YpjP; pfam14005 1052588006193 ribosomal biogenesis protein; Validated; Region: PRK00933 1052588006194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588006195 S-adenosylmethionine binding site [chemical binding]; other site 1052588006196 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1052588006197 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1052588006198 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1052588006199 Virulence factor; Region: Virulence_fact; pfam13769 1052588006200 HEAT repeats; Region: HEAT_2; pfam13646 1052588006201 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1052588006202 HEAT repeats; Region: HEAT_2; pfam13646 1052588006203 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1052588006204 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1052588006205 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052588006206 Zn2+ binding site [ion binding]; other site 1052588006207 Mg2+ binding site [ion binding]; other site 1052588006208 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1052588006209 catalytic residues [active] 1052588006210 dimer interface [polypeptide binding]; other site 1052588006211 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1052588006212 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1052588006213 proposed active site lysine [active] 1052588006214 conserved cys residue [active] 1052588006215 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1052588006216 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1052588006217 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052588006218 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1052588006219 DNA-binding site [nucleotide binding]; DNA binding site 1052588006220 RNA-binding motif; other site 1052588006221 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1052588006222 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1052588006223 hypothetical protein; Validated; Region: PRK07708 1052588006224 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1052588006225 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052588006226 active site 1052588006227 conserved hypothetical integral membrane protein; Region: TIGR00697 1052588006228 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1052588006229 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052588006230 active site 1052588006231 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1052588006232 5'-3' exonuclease; Region: 53EXOc; smart00475 1052588006233 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1052588006234 active site 1052588006235 metal binding site 1 [ion binding]; metal-binding site 1052588006236 putative 5' ssDNA interaction site; other site 1052588006237 metal binding site 3; metal-binding site 1052588006238 metal binding site 2 [ion binding]; metal-binding site 1052588006239 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1052588006240 putative DNA binding site [nucleotide binding]; other site 1052588006241 putative metal binding site [ion binding]; other site 1052588006242 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1052588006243 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1052588006244 Dynamin family; Region: Dynamin_N; pfam00350 1052588006245 G1 box; other site 1052588006246 GTP/Mg2+ binding site [chemical binding]; other site 1052588006247 G2 box; other site 1052588006248 Switch I region; other site 1052588006249 G3 box; other site 1052588006250 Switch II region; other site 1052588006251 G4 box; other site 1052588006252 G5 box; other site 1052588006253 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1052588006254 G1 box; other site 1052588006255 GTP/Mg2+ binding site [chemical binding]; other site 1052588006256 Dynamin family; Region: Dynamin_N; pfam00350 1052588006257 G2 box; other site 1052588006258 Switch I region; other site 1052588006259 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1052588006260 G3 box; other site 1052588006261 Switch II region; other site 1052588006262 GTP/Mg2+ binding site [chemical binding]; other site 1052588006263 G4 box; other site 1052588006264 G5 box; other site 1052588006265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1052588006266 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1052588006267 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1052588006268 malonyl-CoA binding site [chemical binding]; other site 1052588006269 dimer interface [polypeptide binding]; other site 1052588006270 active site 1052588006271 product binding site; other site 1052588006272 xanthine permease; Region: pbuX; TIGR03173 1052588006273 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1052588006274 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588006275 active site 1052588006276 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1052588006277 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1052588006278 active site 1052588006279 Zn binding site [ion binding]; other site 1052588006280 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1052588006281 Entner-Doudoroff aldolase; Region: eda; TIGR01182 1052588006282 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1052588006283 active site 1052588006284 intersubunit interface [polypeptide binding]; other site 1052588006285 catalytic residue [active] 1052588006286 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052588006287 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1052588006288 substrate binding site [chemical binding]; other site 1052588006289 ATP binding site [chemical binding]; other site 1052588006290 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588006291 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588006292 DNA binding site [nucleotide binding] 1052588006293 domain linker motif; other site 1052588006294 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1052588006295 putative dimerization interface [polypeptide binding]; other site 1052588006296 putative ligand binding site [chemical binding]; other site 1052588006297 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1052588006298 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1052588006299 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1052588006300 NADP binding site [chemical binding]; other site 1052588006301 homodimer interface [polypeptide binding]; other site 1052588006302 active site 1052588006303 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1052588006304 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1052588006305 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1052588006306 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1052588006307 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1052588006308 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1052588006309 cell division protein GpsB; Provisional; Region: PRK14127 1052588006310 DivIVA domain; Region: DivI1A_domain; TIGR03544 1052588006311 hypothetical protein; Provisional; Region: PRK13660 1052588006312 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1052588006313 RNase_H superfamily; Region: RNase_H_2; pfam13482 1052588006314 active site 1052588006315 substrate binding site [chemical binding]; other site 1052588006316 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052588006317 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1052588006318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588006319 ATP binding site [chemical binding]; other site 1052588006320 putative Mg++ binding site [ion binding]; other site 1052588006321 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588006322 nucleotide binding region [chemical binding]; other site 1052588006323 ATP-binding site [chemical binding]; other site 1052588006324 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1052588006325 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052588006326 HPr interaction site; other site 1052588006327 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052588006328 active site 1052588006329 phosphorylation site [posttranslational modification] 1052588006330 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1052588006331 YppG-like protein; Region: YppG; pfam14179 1052588006332 YppF-like protein; Region: YppF; pfam14178 1052588006333 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1052588006334 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1052588006335 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1052588006336 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1052588006337 Transglycosylase; Region: Transgly; pfam00912 1052588006338 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052588006339 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052588006340 Interdomain contacts; other site 1052588006341 Cytokine receptor motif; other site 1052588006342 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1052588006343 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052588006344 minor groove reading motif; other site 1052588006345 helix-hairpin-helix signature motif; other site 1052588006346 substrate binding pocket [chemical binding]; other site 1052588006347 active site 1052588006348 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1052588006349 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1052588006350 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1052588006351 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1052588006352 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1052588006353 putative dimer interface [polypeptide binding]; other site 1052588006354 putative anticodon binding site; other site 1052588006355 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1052588006356 homodimer interface [polypeptide binding]; other site 1052588006357 motif 1; other site 1052588006358 motif 2; other site 1052588006359 active site 1052588006360 motif 3; other site 1052588006361 aspartate aminotransferase; Provisional; Region: PRK05764 1052588006362 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588006363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588006364 homodimer interface [polypeptide binding]; other site 1052588006365 catalytic residue [active] 1052588006366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1052588006367 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052588006368 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1052588006369 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1052588006370 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1052588006371 active site 1052588006372 catalytic site [active] 1052588006373 substrate binding site [chemical binding]; other site 1052588006374 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1052588006375 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1052588006376 tetramerization interface [polypeptide binding]; other site 1052588006377 active site 1052588006378 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1052588006379 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1052588006380 active site 1052588006381 ATP-binding site [chemical binding]; other site 1052588006382 pantoate-binding site; other site 1052588006383 HXXH motif; other site 1052588006384 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1052588006385 oligomerization interface [polypeptide binding]; other site 1052588006386 active site 1052588006387 metal binding site [ion binding]; metal-binding site 1052588006388 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1052588006389 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1052588006390 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1052588006391 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1052588006392 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1052588006393 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1052588006394 active site 1052588006395 NTP binding site [chemical binding]; other site 1052588006396 metal binding triad [ion binding]; metal-binding site 1052588006397 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1052588006398 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1052588006399 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1052588006400 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1052588006401 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1052588006402 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1052588006403 active site 1052588006404 dimer interfaces [polypeptide binding]; other site 1052588006405 catalytic residues [active] 1052588006406 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1052588006407 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1052588006408 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1052588006409 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1052588006410 homodimer interface [polypeptide binding]; other site 1052588006411 metal binding site [ion binding]; metal-binding site 1052588006412 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052588006413 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588006414 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588006415 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052588006416 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 1052588006417 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1052588006418 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1052588006419 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1052588006420 intrachain domain interface; other site 1052588006421 Qi binding site; other site 1052588006422 Qo binding site; other site 1052588006423 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1052588006424 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1052588006425 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1052588006426 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1052588006427 interchain domain interface [polypeptide binding]; other site 1052588006428 intrachain domain interface; other site 1052588006429 heme bH binding site [chemical binding]; other site 1052588006430 Qi binding site; other site 1052588006431 heme bL binding site [chemical binding]; other site 1052588006432 Qo binding site; other site 1052588006433 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1052588006434 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1052588006435 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1052588006436 iron-sulfur cluster [ion binding]; other site 1052588006437 [2Fe-2S] cluster binding site [ion binding]; other site 1052588006438 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1052588006439 hypothetical protein; Provisional; Region: PRK03636 1052588006440 UPF0302 domain; Region: UPF0302; pfam08864 1052588006441 IDEAL domain; Region: IDEAL; pfam08858 1052588006442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588006443 TPR motif; other site 1052588006444 binding surface 1052588006445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588006446 binding surface 1052588006447 TPR motif; other site 1052588006448 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052588006449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588006450 TPR motif; other site 1052588006451 binding surface 1052588006452 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1052588006453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588006454 binding surface 1052588006455 TPR motif; other site 1052588006456 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1052588006457 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1052588006458 hinge; other site 1052588006459 active site 1052588006460 prephenate dehydrogenase; Validated; Region: PRK06545 1052588006461 prephenate dehydrogenase; Validated; Region: PRK08507 1052588006462 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1052588006463 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1052588006464 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588006465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588006466 homodimer interface [polypeptide binding]; other site 1052588006467 catalytic residue [active] 1052588006468 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1052588006469 substrate binding site [chemical binding]; other site 1052588006470 active site 1052588006471 catalytic residues [active] 1052588006472 heterodimer interface [polypeptide binding]; other site 1052588006473 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1052588006474 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1052588006475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588006476 catalytic residue [active] 1052588006477 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1052588006478 active site 1052588006479 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1052588006480 active site 1052588006481 ribulose/triose binding site [chemical binding]; other site 1052588006482 phosphate binding site [ion binding]; other site 1052588006483 substrate (anthranilate) binding pocket [chemical binding]; other site 1052588006484 product (indole) binding pocket [chemical binding]; other site 1052588006485 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1052588006486 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1052588006487 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1052588006488 anthranilate synthase component I; Provisional; Region: PRK13569 1052588006489 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1052588006490 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1052588006491 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1052588006492 homotrimer interaction site [polypeptide binding]; other site 1052588006493 active site 1052588006494 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1052588006495 active site 1052588006496 dimer interface [polypeptide binding]; other site 1052588006497 metal binding site [ion binding]; metal-binding site 1052588006498 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1052588006499 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1052588006500 Tetramer interface [polypeptide binding]; other site 1052588006501 active site 1052588006502 FMN-binding site [chemical binding]; other site 1052588006503 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1052588006504 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1052588006505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588006506 S-adenosylmethionine binding site [chemical binding]; other site 1052588006507 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1052588006508 active site 1052588006509 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1052588006510 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1052588006511 substrate binding pocket [chemical binding]; other site 1052588006512 chain length determination region; other site 1052588006513 substrate-Mg2+ binding site; other site 1052588006514 catalytic residues [active] 1052588006515 aspartate-rich region 1; other site 1052588006516 active site lid residues [active] 1052588006517 aspartate-rich region 2; other site 1052588006518 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1052588006519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588006520 S-adenosylmethionine binding site [chemical binding]; other site 1052588006521 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1052588006522 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1052588006523 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1052588006524 homodecamer interface [polypeptide binding]; other site 1052588006525 GTP cyclohydrolase I; Provisional; Region: PLN03044 1052588006526 active site 1052588006527 putative catalytic site residues [active] 1052588006528 zinc binding site [ion binding]; other site 1052588006529 GTP-CH-I/GFRP interaction surface; other site 1052588006530 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1052588006531 IHF dimer interface [polypeptide binding]; other site 1052588006532 IHF - DNA interface [nucleotide binding]; other site 1052588006533 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1052588006534 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1052588006535 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1052588006536 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1052588006537 GTP-binding protein Der; Reviewed; Region: PRK00093 1052588006538 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1052588006539 G1 box; other site 1052588006540 GTP/Mg2+ binding site [chemical binding]; other site 1052588006541 Switch I region; other site 1052588006542 G2 box; other site 1052588006543 Switch II region; other site 1052588006544 G3 box; other site 1052588006545 G4 box; other site 1052588006546 G5 box; other site 1052588006547 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1052588006548 G1 box; other site 1052588006549 GTP/Mg2+ binding site [chemical binding]; other site 1052588006550 Switch I region; other site 1052588006551 G2 box; other site 1052588006552 G3 box; other site 1052588006553 Switch II region; other site 1052588006554 G4 box; other site 1052588006555 G5 box; other site 1052588006556 YIEGIA protein; Region: YIEGIA; pfam14045 1052588006557 YpzI-like protein; Region: YpzI; pfam14140 1052588006558 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1052588006559 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1052588006560 homotetramer interface [polypeptide binding]; other site 1052588006561 FMN binding site [chemical binding]; other site 1052588006562 homodimer contacts [polypeptide binding]; other site 1052588006563 putative active site [active] 1052588006564 putative substrate binding site [chemical binding]; other site 1052588006565 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1052588006566 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1052588006567 RNA binding site [nucleotide binding]; other site 1052588006568 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1052588006569 RNA binding site [nucleotide binding]; other site 1052588006570 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052588006571 RNA binding site [nucleotide binding]; other site 1052588006572 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1052588006573 RNA binding site [nucleotide binding]; other site 1052588006574 cytidylate kinase; Provisional; Region: cmk; PRK00023 1052588006575 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1052588006576 CMP-binding site; other site 1052588006577 The sites determining sugar specificity; other site 1052588006578 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1052588006579 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1052588006580 PilZ domain; Region: PilZ; pfam07238 1052588006581 germination protein YpeB; Region: spore_YpeB; TIGR02889 1052588006582 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052588006583 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052588006584 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1052588006585 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1052588006586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1052588006587 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588006588 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1052588006589 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1052588006590 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1052588006591 NAD(P) binding site [chemical binding]; other site 1052588006592 adaptor protein; Provisional; Region: PRK02899 1052588006593 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1052588006594 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052588006595 putative active site [active] 1052588006596 putative metal binding site [ion binding]; other site 1052588006597 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1052588006598 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588006599 CAAX protease self-immunity; Region: Abi; pfam02517 1052588006600 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1052588006601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588006602 ATP binding site [chemical binding]; other site 1052588006603 putative Mg++ binding site [ion binding]; other site 1052588006604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588006605 nucleotide binding region [chemical binding]; other site 1052588006606 ATP-binding site [chemical binding]; other site 1052588006607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1052588006608 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1052588006609 Predicted membrane protein [Function unknown]; Region: COG3601 1052588006610 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1052588006611 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1052588006612 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1052588006613 ligand binding site [chemical binding]; other site 1052588006614 NAD binding site [chemical binding]; other site 1052588006615 dimerization interface [polypeptide binding]; other site 1052588006616 catalytic site [active] 1052588006617 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1052588006618 putative L-serine binding site [chemical binding]; other site 1052588006619 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1052588006620 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1052588006621 active site 1052588006622 catalytic residue [active] 1052588006623 dimer interface [polypeptide binding]; other site 1052588006624 Sporulation and spore germination; Region: Germane; cl11253 1052588006625 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1052588006626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588006627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588006628 DNA binding residues [nucleotide binding] 1052588006629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1052588006630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588006631 dimerization interface [polypeptide binding]; other site 1052588006632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588006633 putative active site [active] 1052588006634 heme pocket [chemical binding]; other site 1052588006635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588006636 dimer interface [polypeptide binding]; other site 1052588006637 phosphorylation site [posttranslational modification] 1052588006638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588006639 ATP binding site [chemical binding]; other site 1052588006640 Mg2+ binding site [ion binding]; other site 1052588006641 G-X-G motif; other site 1052588006642 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588006643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588006644 active site 1052588006645 phosphorylation site [posttranslational modification] 1052588006646 intermolecular recognition site; other site 1052588006647 dimerization interface [polypeptide binding]; other site 1052588006648 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588006649 DNA binding site [nucleotide binding] 1052588006650 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1052588006651 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1052588006652 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1052588006653 ResB-like family; Region: ResB; pfam05140 1052588006654 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052588006655 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052588006656 catalytic residues [active] 1052588006657 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1052588006658 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588006659 RNA binding surface [nucleotide binding]; other site 1052588006660 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1052588006661 active site 1052588006662 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1052588006663 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1052588006664 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1052588006665 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1052588006666 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1052588006667 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1052588006668 segregation and condensation protein B; Region: TIGR00281 1052588006669 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1052588006670 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1052588006671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588006672 Coenzyme A binding pocket [chemical binding]; other site 1052588006673 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1052588006674 homopentamer interface [polypeptide binding]; other site 1052588006675 active site 1052588006676 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1052588006677 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1052588006678 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1052588006679 dimerization interface [polypeptide binding]; other site 1052588006680 active site 1052588006681 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1052588006682 Lumazine binding domain; Region: Lum_binding; pfam00677 1052588006683 Lumazine binding domain; Region: Lum_binding; pfam00677 1052588006684 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1052588006685 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1052588006686 catalytic motif [active] 1052588006687 Zn binding site [ion binding]; other site 1052588006688 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1052588006689 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052588006690 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052588006691 Catalytic site [active] 1052588006692 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 1052588006693 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1052588006694 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588006695 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1052588006696 active site 1052588006697 Bacterial SH3 domain; Region: SH3_3; pfam08239 1052588006698 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1052588006699 active site 1052588006700 Predicted secreted protein [Function unknown]; Region: COG4086 1052588006701 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1052588006702 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1052588006703 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1052588006704 active site 1052588006705 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052588006706 substrate binding site [chemical binding]; other site 1052588006707 catalytic residues [active] 1052588006708 dimer interface [polypeptide binding]; other site 1052588006709 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052588006710 stage V sporulation protein AD; Validated; Region: PRK08304 1052588006711 stage V sporulation protein AD; Provisional; Region: PRK12404 1052588006712 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1052588006713 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1052588006714 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1052588006715 sporulation sigma factor SigF; Validated; Region: PRK05572 1052588006716 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588006717 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052588006718 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588006719 DNA binding residues [nucleotide binding] 1052588006720 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1052588006721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588006722 ATP binding site [chemical binding]; other site 1052588006723 Mg2+ binding site [ion binding]; other site 1052588006724 G-X-G motif; other site 1052588006725 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1052588006726 phosphopentomutase; Provisional; Region: PRK05362 1052588006727 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1052588006728 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1052588006729 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1052588006730 active site 1052588006731 Int/Topo IB signature motif; other site 1052588006732 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1052588006733 ferric uptake regulator; Provisional; Region: fur; PRK09462 1052588006734 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052588006735 metal binding site 2 [ion binding]; metal-binding site 1052588006736 putative DNA binding helix; other site 1052588006737 metal binding site 1 [ion binding]; metal-binding site 1052588006738 dimer interface [polypeptide binding]; other site 1052588006739 structural Zn2+ binding site [ion binding]; other site 1052588006740 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1052588006741 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1052588006742 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1052588006743 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052588006744 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1052588006745 NAD(P) binding pocket [chemical binding]; other site 1052588006746 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1052588006747 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1052588006748 Aspartase; Region: Aspartase; cd01357 1052588006749 active sites [active] 1052588006750 tetramer interface [polypeptide binding]; other site 1052588006751 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1052588006752 active site 1052588006753 homodimer interface [polypeptide binding]; other site 1052588006754 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052588006755 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588006756 non-specific DNA binding site [nucleotide binding]; other site 1052588006757 salt bridge; other site 1052588006758 sequence-specific DNA binding site [nucleotide binding]; other site 1052588006759 TIGR00375 family protein; Region: TIGR00375 1052588006760 PHP-associated; Region: PHP_C; pfam13263 1052588006761 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1052588006762 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1052588006763 dimer interface [polypeptide binding]; other site 1052588006764 ADP-ribose binding site [chemical binding]; other site 1052588006765 active site 1052588006766 nudix motif; other site 1052588006767 metal binding site [ion binding]; metal-binding site 1052588006768 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1052588006769 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588006770 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052588006771 active site 1052588006772 catalytic tetrad [active] 1052588006773 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1052588006774 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052588006775 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1052588006776 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1052588006777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1052588006778 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052588006779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588006780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052588006781 Coenzyme A binding pocket [chemical binding]; other site 1052588006782 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1052588006783 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1052588006784 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1052588006785 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588006786 Coenzyme A binding pocket [chemical binding]; other site 1052588006787 YolD-like protein; Region: YolD; pfam08863 1052588006788 DNA polymerase IV; Reviewed; Region: PRK03103 1052588006789 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1052588006790 active site 1052588006791 DNA binding site [nucleotide binding] 1052588006792 YqzH-like protein; Region: YqzH; pfam14164 1052588006793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588006794 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588006795 putative substrate translocation pore; other site 1052588006796 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1052588006797 putative dimer interface [polypeptide binding]; other site 1052588006798 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588006799 ligand binding site [chemical binding]; other site 1052588006800 Zn binding site [ion binding]; other site 1052588006801 pantothenate kinase; Provisional; Region: PRK05439 1052588006802 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1052588006803 ATP-binding site [chemical binding]; other site 1052588006804 CoA-binding site [chemical binding]; other site 1052588006805 Mg2+-binding site [ion binding]; other site 1052588006806 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1052588006807 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1052588006808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588006809 catalytic residue [active] 1052588006810 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1052588006811 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 1052588006812 NADP binding site [chemical binding]; other site 1052588006813 homodimer interface [polypeptide binding]; other site 1052588006814 substrate binding site [chemical binding]; other site 1052588006815 active site 1052588006816 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1052588006817 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1052588006818 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1052588006819 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1052588006820 putative metal binding site [ion binding]; other site 1052588006821 putative dimer interface [polypeptide binding]; other site 1052588006822 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1052588006823 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1052588006824 active site 1052588006825 FMN binding site [chemical binding]; other site 1052588006826 substrate binding site [chemical binding]; other site 1052588006827 homotetramer interface [polypeptide binding]; other site 1052588006828 catalytic residue [active] 1052588006829 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588006830 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1052588006831 putative hydrolase; Provisional; Region: PRK02113 1052588006832 ribonuclease Z; Region: RNase_Z; TIGR02651 1052588006833 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1052588006834 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1052588006835 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1052588006836 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1052588006837 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1052588006838 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1052588006839 DNA polymerase IV; Validated; Region: PRK01810 1052588006840 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1052588006841 active site 1052588006842 DNA binding site [nucleotide binding] 1052588006843 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1052588006844 OxaA-like protein precursor; Validated; Region: PRK01622 1052588006845 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 1052588006846 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1052588006847 peptidase T-like protein; Region: PepT-like; TIGR01883 1052588006848 metal binding site [ion binding]; metal-binding site 1052588006849 putative dimer interface [polypeptide binding]; other site 1052588006850 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1052588006851 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1052588006852 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1052588006853 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588006854 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1052588006855 dimer interface [polypeptide binding]; other site 1052588006856 substrate binding site [chemical binding]; other site 1052588006857 metal binding site [ion binding]; metal-binding site 1052588006858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1052588006859 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1052588006860 Predicted membrane protein [Function unknown]; Region: COG4129 1052588006861 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1052588006862 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1052588006863 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052588006864 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052588006865 Walker A/P-loop; other site 1052588006866 ATP binding site [chemical binding]; other site 1052588006867 Q-loop/lid; other site 1052588006868 ABC transporter signature motif; other site 1052588006869 Walker B; other site 1052588006870 D-loop; other site 1052588006871 H-loop/switch region; other site 1052588006872 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052588006873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588006874 dimer interface [polypeptide binding]; other site 1052588006875 conserved gate region; other site 1052588006876 putative PBP binding loops; other site 1052588006877 ABC-ATPase subunit interface; other site 1052588006878 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052588006879 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052588006880 substrate binding pocket [chemical binding]; other site 1052588006881 membrane-bound complex binding site; other site 1052588006882 hinge residues; other site 1052588006883 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1052588006884 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1052588006885 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1052588006886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588006887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588006888 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052588006889 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052588006890 DNA binding residues [nucleotide binding] 1052588006891 drug binding residues [chemical binding]; other site 1052588006892 dimer interface [polypeptide binding]; other site 1052588006893 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1052588006894 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1052588006895 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052588006896 E3 interaction surface; other site 1052588006897 lipoyl attachment site [posttranslational modification]; other site 1052588006898 e3 binding domain; Region: E3_binding; pfam02817 1052588006899 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1052588006900 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052588006901 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052588006902 alpha subunit interface [polypeptide binding]; other site 1052588006903 TPP binding site [chemical binding]; other site 1052588006904 heterodimer interface [polypeptide binding]; other site 1052588006905 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052588006906 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1052588006907 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052588006908 tetramer interface [polypeptide binding]; other site 1052588006909 TPP-binding site [chemical binding]; other site 1052588006910 heterodimer interface [polypeptide binding]; other site 1052588006911 phosphorylation loop region [posttranslational modification] 1052588006912 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1052588006913 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1052588006914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588006915 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052588006916 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052588006917 nucleotide binding site [chemical binding]; other site 1052588006918 Acetokinase family; Region: Acetate_kinase; cl17229 1052588006919 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1052588006920 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1052588006921 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1052588006922 NAD binding site [chemical binding]; other site 1052588006923 Phe binding site; other site 1052588006924 phosphate butyryltransferase; Validated; Region: PRK07742 1052588006925 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1052588006926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588006927 putative active site [active] 1052588006928 heme pocket [chemical binding]; other site 1052588006929 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588006930 putative active site [active] 1052588006931 heme pocket [chemical binding]; other site 1052588006932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588006933 Walker A motif; other site 1052588006934 ATP binding site [chemical binding]; other site 1052588006935 Walker B motif; other site 1052588006936 arginine finger; other site 1052588006937 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1052588006938 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1052588006939 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1052588006940 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1052588006941 tetramer interface [polypeptide binding]; other site 1052588006942 active site 1052588006943 Mg2+/Mn2+ binding site [ion binding]; other site 1052588006944 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1052588006945 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1052588006946 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1052588006947 dimer interface [polypeptide binding]; other site 1052588006948 Citrate synthase; Region: Citrate_synt; pfam00285 1052588006949 active site 1052588006950 coenzyme A binding site [chemical binding]; other site 1052588006951 citrylCoA binding site [chemical binding]; other site 1052588006952 oxalacetate/citrate binding site [chemical binding]; other site 1052588006953 catalytic triad [active] 1052588006954 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052588006955 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1052588006956 FAD binding site [chemical binding]; other site 1052588006957 homotetramer interface [polypeptide binding]; other site 1052588006958 substrate binding pocket [chemical binding]; other site 1052588006959 catalytic base [active] 1052588006960 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1052588006961 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1052588006962 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1052588006963 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1052588006964 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1052588006965 dimer interface [polypeptide binding]; other site 1052588006966 active site 1052588006967 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1052588006968 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1052588006969 active site 1052588006970 catalytic site [active] 1052588006971 metal binding site [ion binding]; metal-binding site 1052588006972 dimer interface [polypeptide binding]; other site 1052588006973 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1052588006974 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052588006975 active site 1052588006976 metal binding site [ion binding]; metal-binding site 1052588006977 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1052588006978 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1052588006979 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1052588006980 putative active site [active] 1052588006981 putative FMN binding site [chemical binding]; other site 1052588006982 putative substrate binding site [chemical binding]; other site 1052588006983 putative catalytic residue [active] 1052588006984 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1052588006985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588006986 active site 1052588006987 phosphorylation site [posttranslational modification] 1052588006988 intermolecular recognition site; other site 1052588006989 dimerization interface [polypeptide binding]; other site 1052588006990 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1052588006991 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1052588006992 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1052588006993 protein binding site [polypeptide binding]; other site 1052588006994 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1052588006995 DNA repair protein RecN; Region: recN; TIGR00634 1052588006996 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1052588006997 Walker A/P-loop; other site 1052588006998 ATP binding site [chemical binding]; other site 1052588006999 Q-loop/lid; other site 1052588007000 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1052588007001 ABC transporter signature motif; other site 1052588007002 Walker B; other site 1052588007003 D-loop; other site 1052588007004 H-loop/switch region; other site 1052588007005 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1052588007006 arginine repressor; Provisional; Region: PRK04280 1052588007007 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1052588007008 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1052588007009 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588007010 RNA binding surface [nucleotide binding]; other site 1052588007011 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1052588007012 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1052588007013 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1052588007014 TPP-binding site; other site 1052588007015 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1052588007016 PYR/PP interface [polypeptide binding]; other site 1052588007017 dimer interface [polypeptide binding]; other site 1052588007018 TPP binding site [chemical binding]; other site 1052588007019 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052588007020 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1052588007021 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1052588007022 substrate binding pocket [chemical binding]; other site 1052588007023 chain length determination region; other site 1052588007024 substrate-Mg2+ binding site; other site 1052588007025 catalytic residues [active] 1052588007026 aspartate-rich region 1; other site 1052588007027 active site lid residues [active] 1052588007028 aspartate-rich region 2; other site 1052588007029 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1052588007030 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1052588007031 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1052588007032 generic binding surface II; other site 1052588007033 generic binding surface I; other site 1052588007034 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1052588007035 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1052588007036 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1052588007037 homodimer interface [polypeptide binding]; other site 1052588007038 NADP binding site [chemical binding]; other site 1052588007039 substrate binding site [chemical binding]; other site 1052588007040 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1052588007041 putative RNA binding site [nucleotide binding]; other site 1052588007042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1052588007043 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1052588007044 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588007045 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1052588007046 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1052588007047 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1052588007048 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052588007049 carboxyltransferase (CT) interaction site; other site 1052588007050 biotinylation site [posttranslational modification]; other site 1052588007051 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1052588007052 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1052588007053 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1052588007054 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1052588007055 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1052588007056 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1052588007057 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1052588007058 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1052588007059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588007060 Walker A motif; other site 1052588007061 ATP binding site [chemical binding]; other site 1052588007062 Walker B motif; other site 1052588007063 arginine finger; other site 1052588007064 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1052588007065 elongation factor P; Validated; Region: PRK00529 1052588007066 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1052588007067 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1052588007068 RNA binding site [nucleotide binding]; other site 1052588007069 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1052588007070 RNA binding site [nucleotide binding]; other site 1052588007071 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1052588007072 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1052588007073 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1052588007074 active site 1052588007075 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1052588007076 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1052588007077 trimer interface [polypeptide binding]; other site 1052588007078 active site 1052588007079 dimer interface [polypeptide binding]; other site 1052588007080 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1052588007081 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1052588007082 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1052588007083 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1052588007084 active site 1052588007085 nucleophile elbow; other site 1052588007086 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1052588007087 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1052588007088 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1052588007089 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1052588007090 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052588007091 active site residue [active] 1052588007092 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1052588007093 tetramer interface [polypeptide binding]; other site 1052588007094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588007095 catalytic residue [active] 1052588007096 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1052588007097 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1052588007098 tetramer interface [polypeptide binding]; other site 1052588007099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588007100 catalytic residue [active] 1052588007101 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1052588007102 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1052588007103 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1052588007104 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1052588007105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588007106 ATP binding site [chemical binding]; other site 1052588007107 putative Mg++ binding site [ion binding]; other site 1052588007108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588007109 nucleotide binding region [chemical binding]; other site 1052588007110 ATP-binding site [chemical binding]; other site 1052588007111 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1052588007112 Anti-repressor SinI; Region: SinI; pfam08671 1052588007113 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052588007114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588007115 non-specific DNA binding site [nucleotide binding]; other site 1052588007116 salt bridge; other site 1052588007117 sequence-specific DNA binding site [nucleotide binding]; other site 1052588007118 Anti-repressor SinI; Region: SinI; pfam08671 1052588007119 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1052588007120 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052588007121 Catalytic site [active] 1052588007122 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1052588007123 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1052588007124 YqzE-like protein; Region: YqzE; pfam14038 1052588007125 ComG operon protein 7; Region: ComGG; pfam14173 1052588007126 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1052588007127 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1052588007128 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1052588007129 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1052588007130 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1052588007131 Type II/IV secretion system protein; Region: T2SE; pfam00437 1052588007132 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1052588007133 Walker A motif; other site 1052588007134 ATP binding site [chemical binding]; other site 1052588007135 Walker B motif; other site 1052588007136 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1052588007137 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1052588007138 Cl binding site [ion binding]; other site 1052588007139 oligomer interface [polypeptide binding]; other site 1052588007140 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052588007141 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052588007142 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052588007143 Transporter associated domain; Region: CorC_HlyC; smart01091 1052588007144 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588007145 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1052588007146 ArsC family; Region: ArsC; pfam03960 1052588007147 putative catalytic residues [active] 1052588007148 thiol/disulfide switch; other site 1052588007149 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1052588007150 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052588007151 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1052588007152 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1052588007153 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1052588007154 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1052588007155 putative active site [active] 1052588007156 Zn binding site [ion binding]; other site 1052588007157 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052588007158 Sulfatase; Region: Sulfatase; pfam00884 1052588007159 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1052588007160 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052588007161 nucleotide binding site [chemical binding]; other site 1052588007162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1052588007163 Rhomboid family; Region: Rhomboid; pfam01694 1052588007164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588007165 binding surface 1052588007166 TPR motif; other site 1052588007167 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1052588007168 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1052588007169 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588007170 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052588007171 YceG-like family; Region: YceG; pfam02618 1052588007172 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1052588007173 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1052588007174 Walker A/P-loop; other site 1052588007175 ATP binding site [chemical binding]; other site 1052588007176 Q-loop/lid; other site 1052588007177 ABC transporter signature motif; other site 1052588007178 Walker B; other site 1052588007179 D-loop; other site 1052588007180 H-loop/switch region; other site 1052588007181 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1052588007182 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1052588007183 Walker A/P-loop; other site 1052588007184 ATP binding site [chemical binding]; other site 1052588007185 Q-loop/lid; other site 1052588007186 ABC transporter signature motif; other site 1052588007187 Walker B; other site 1052588007188 D-loop; other site 1052588007189 H-loop/switch region; other site 1052588007190 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1052588007191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588007192 dimer interface [polypeptide binding]; other site 1052588007193 conserved gate region; other site 1052588007194 ABC-ATPase subunit interface; other site 1052588007195 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1052588007196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588007197 dimer interface [polypeptide binding]; other site 1052588007198 conserved gate region; other site 1052588007199 putative PBP binding loops; other site 1052588007200 ABC-ATPase subunit interface; other site 1052588007201 PBP superfamily domain; Region: PBP_like_2; cl17296 1052588007202 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1052588007203 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052588007204 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588007205 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052588007206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588007207 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588007208 putative substrate translocation pore; other site 1052588007209 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1052588007210 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1052588007211 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1052588007212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1052588007213 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1052588007214 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588007215 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1052588007216 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1052588007217 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1052588007218 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1052588007219 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1052588007220 ferric uptake regulator; Provisional; Region: fur; PRK09462 1052588007221 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052588007222 metal binding site 2 [ion binding]; metal-binding site 1052588007223 putative DNA binding helix; other site 1052588007224 metal binding site 1 [ion binding]; metal-binding site 1052588007225 dimer interface [polypeptide binding]; other site 1052588007226 structural Zn2+ binding site [ion binding]; other site 1052588007227 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052588007228 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588007229 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588007230 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052588007231 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1052588007232 endonuclease IV; Provisional; Region: PRK01060 1052588007233 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1052588007234 AP (apurinic/apyrimidinic) site pocket; other site 1052588007235 DNA interaction; other site 1052588007236 Metal-binding active site; metal-binding site 1052588007237 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052588007238 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1052588007239 ATP binding site [chemical binding]; other site 1052588007240 Mg++ binding site [ion binding]; other site 1052588007241 motif III; other site 1052588007242 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588007243 nucleotide binding region [chemical binding]; other site 1052588007244 ATP-binding site [chemical binding]; other site 1052588007245 YqfQ-like protein; Region: YqfQ; pfam14181 1052588007246 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1052588007247 LytB protein; Region: LYTB; pfam02401 1052588007248 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1052588007249 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 1052588007250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1052588007251 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1052588007252 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1052588007253 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1052588007254 Family of unknown function (DUF633); Region: DUF633; pfam04816 1052588007255 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1052588007256 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1052588007257 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1052588007258 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1052588007259 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1052588007260 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588007261 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052588007262 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588007263 DNA binding residues [nucleotide binding] 1052588007264 DNA primase; Validated; Region: dnaG; PRK05667 1052588007265 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1052588007266 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1052588007267 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1052588007268 active site 1052588007269 metal binding site [ion binding]; metal-binding site 1052588007270 interdomain interaction site; other site 1052588007271 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1052588007272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1052588007273 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1052588007274 HTH domain; Region: HTH_11; pfam08279 1052588007275 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1052588007276 FOG: CBS domain [General function prediction only]; Region: COG0517 1052588007277 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1052588007278 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1052588007279 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1052588007280 dimer interface [polypeptide binding]; other site 1052588007281 motif 1; other site 1052588007282 active site 1052588007283 motif 2; other site 1052588007284 motif 3; other site 1052588007285 Recombination protein O N terminal; Region: RecO_N; pfam11967 1052588007286 DNA repair protein RecO; Region: reco; TIGR00613 1052588007287 Recombination protein O C terminal; Region: RecO_C; pfam02565 1052588007288 YqzL-like protein; Region: YqzL; pfam14006 1052588007289 GTPase Era; Reviewed; Region: era; PRK00089 1052588007290 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1052588007291 G1 box; other site 1052588007292 GTP/Mg2+ binding site [chemical binding]; other site 1052588007293 Switch I region; other site 1052588007294 G2 box; other site 1052588007295 Switch II region; other site 1052588007296 G3 box; other site 1052588007297 G4 box; other site 1052588007298 G5 box; other site 1052588007299 KH domain; Region: KH_2; pfam07650 1052588007300 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1052588007301 active site 1052588007302 catalytic motif [active] 1052588007303 Zn binding site [ion binding]; other site 1052588007304 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1052588007305 metal-binding heat shock protein; Provisional; Region: PRK00016 1052588007306 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1052588007307 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1052588007308 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052588007309 Zn2+ binding site [ion binding]; other site 1052588007310 Mg2+ binding site [ion binding]; other site 1052588007311 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1052588007312 PhoH-like protein; Region: PhoH; pfam02562 1052588007313 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1052588007314 hypothetical protein; Provisional; Region: PRK13665 1052588007315 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1052588007316 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1052588007317 dimer interface [polypeptide binding]; other site 1052588007318 active site residues [active] 1052588007319 Yqey-like protein; Region: YqeY; pfam09424 1052588007320 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1052588007321 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1052588007322 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052588007323 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052588007324 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1052588007325 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1052588007326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588007327 FeS/SAM binding site; other site 1052588007328 TRAM domain; Region: TRAM; cl01282 1052588007329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1052588007330 RNA methyltransferase, RsmE family; Region: TIGR00046 1052588007331 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1052588007332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588007333 S-adenosylmethionine binding site [chemical binding]; other site 1052588007334 chaperone protein DnaJ; Provisional; Region: PRK14280 1052588007335 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1052588007336 HSP70 interaction site [polypeptide binding]; other site 1052588007337 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1052588007338 substrate binding site [polypeptide binding]; other site 1052588007339 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1052588007340 Zn binding sites [ion binding]; other site 1052588007341 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1052588007342 dimer interface [polypeptide binding]; other site 1052588007343 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1052588007344 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1052588007345 nucleotide binding site [chemical binding]; other site 1052588007346 NEF interaction site [polypeptide binding]; other site 1052588007347 SBD interface [polypeptide binding]; other site 1052588007348 GrpE; Region: GrpE; pfam01025 1052588007349 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1052588007350 dimer interface [polypeptide binding]; other site 1052588007351 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1052588007352 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1052588007353 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1052588007354 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1052588007355 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588007356 FeS/SAM binding site; other site 1052588007357 HemN C-terminal domain; Region: HemN_C; pfam06969 1052588007358 GTP-binding protein LepA; Provisional; Region: PRK05433 1052588007359 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1052588007360 G1 box; other site 1052588007361 putative GEF interaction site [polypeptide binding]; other site 1052588007362 GTP/Mg2+ binding site [chemical binding]; other site 1052588007363 Switch I region; other site 1052588007364 G2 box; other site 1052588007365 G3 box; other site 1052588007366 Switch II region; other site 1052588007367 G4 box; other site 1052588007368 G5 box; other site 1052588007369 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1052588007370 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1052588007371 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1052588007372 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1052588007373 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1052588007374 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1052588007375 germination protease; Provisional; Region: PRK02858 1052588007376 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1052588007377 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1052588007378 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1052588007379 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1052588007380 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1052588007381 Competence protein; Region: Competence; pfam03772 1052588007382 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052588007383 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1052588007384 catalytic motif [active] 1052588007385 Zn binding site [ion binding]; other site 1052588007386 SLBB domain; Region: SLBB; pfam10531 1052588007387 comEA protein; Region: comE; TIGR01259 1052588007388 Helix-hairpin-helix motif; Region: HHH; pfam00633 1052588007389 late competence protein ComER; Validated; Region: PRK07680 1052588007390 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1052588007391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588007392 S-adenosylmethionine binding site [chemical binding]; other site 1052588007393 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1052588007394 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052588007395 Zn2+ binding site [ion binding]; other site 1052588007396 Mg2+ binding site [ion binding]; other site 1052588007397 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1052588007398 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1052588007399 active site 1052588007400 (T/H)XGH motif; other site 1052588007401 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 1052588007402 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1052588007403 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1052588007404 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1052588007405 shikimate binding site; other site 1052588007406 NAD(P) binding site [chemical binding]; other site 1052588007407 GTPase YqeH; Provisional; Region: PRK13796 1052588007408 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1052588007409 GTP/Mg2+ binding site [chemical binding]; other site 1052588007410 G4 box; other site 1052588007411 G5 box; other site 1052588007412 G1 box; other site 1052588007413 Switch I region; other site 1052588007414 G2 box; other site 1052588007415 G3 box; other site 1052588007416 Switch II region; other site 1052588007417 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1052588007418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588007419 active site 1052588007420 motif I; other site 1052588007421 motif II; other site 1052588007422 Sporulation inhibitor A; Region: Sda; pfam08970 1052588007423 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 1052588007424 active site 1052588007425 catalytic triad [active] 1052588007426 oxyanion hole [active] 1052588007427 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1052588007428 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052588007429 amidase catalytic site [active] 1052588007430 Zn binding residues [ion binding]; other site 1052588007431 substrate binding site [chemical binding]; other site 1052588007432 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052588007433 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052588007434 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1052588007435 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052588007436 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1052588007437 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1052588007438 arginine decarboxylase; Provisional; Region: PRK15029 1052588007439 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1052588007440 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1052588007441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588007442 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588007443 DNA binding residues [nucleotide binding] 1052588007444 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052588007445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588007446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588007447 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1052588007448 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1052588007449 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052588007450 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052588007451 dimerization domain swap beta strand [polypeptide binding]; other site 1052588007452 regulatory protein interface [polypeptide binding]; other site 1052588007453 regulatory phosphorylation site [posttranslational modification]; other site 1052588007454 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1052588007455 classical (c) SDRs; Region: SDR_c; cd05233 1052588007456 NAD(P) binding site [chemical binding]; other site 1052588007457 active site 1052588007458 putative arabinose transporter; Provisional; Region: PRK03545 1052588007459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588007460 putative substrate translocation pore; other site 1052588007461 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1052588007462 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1052588007463 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588007464 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052588007465 active site 1052588007466 catalytic tetrad [active] 1052588007467 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1052588007468 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1052588007469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052588007470 binding surface 1052588007471 TPR motif; other site 1052588007472 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588007473 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588007474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588007475 binding surface 1052588007476 TPR motif; other site 1052588007477 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588007478 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052588007479 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1052588007480 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1052588007481 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1052588007482 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1052588007483 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1052588007484 Predicted transcriptional regulators [Transcription]; Region: COG1695 1052588007485 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1052588007486 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052588007487 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1052588007488 DNA binding residues [nucleotide binding] 1052588007489 dimer interface [polypeptide binding]; other site 1052588007490 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1052588007491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588007492 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588007493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588007494 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052588007495 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052588007496 Coenzyme A binding pocket [chemical binding]; other site 1052588007497 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052588007498 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052588007499 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052588007500 Transporter associated domain; Region: CorC_HlyC; smart01091 1052588007501 YrzO-like protein; Region: YrzO; pfam14142 1052588007502 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1052588007503 RNAase interaction site [polypeptide binding]; other site 1052588007504 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052588007505 Cytochrome P450; Region: p450; cl12078 1052588007506 Isochorismatase family; Region: Isochorismatase; pfam00857 1052588007507 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1052588007508 catalytic triad [active] 1052588007509 conserved cis-peptide bond; other site 1052588007510 DinB family; Region: DinB; pfam05163 1052588007511 DinB superfamily; Region: DinB_2; pfam12867 1052588007512 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1052588007513 Nitronate monooxygenase; Region: NMO; pfam03060 1052588007514 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1052588007515 FMN binding site [chemical binding]; other site 1052588007516 substrate binding site [chemical binding]; other site 1052588007517 putative catalytic residue [active] 1052588007518 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1052588007519 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588007520 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052588007521 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1052588007522 dimer interface [polypeptide binding]; other site 1052588007523 FMN binding site [chemical binding]; other site 1052588007524 NADPH bind site [chemical binding]; other site 1052588007525 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052588007526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588007527 putative DNA binding site [nucleotide binding]; other site 1052588007528 dimerization interface [polypeptide binding]; other site 1052588007529 putative Zn2+ binding site [ion binding]; other site 1052588007530 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1052588007531 putative binding site; other site 1052588007532 putative dimer interface [polypeptide binding]; other site 1052588007533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1052588007534 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1052588007535 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1052588007536 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052588007537 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052588007538 DNA binding residues [nucleotide binding] 1052588007539 drug binding residues [chemical binding]; other site 1052588007540 dimer interface [polypeptide binding]; other site 1052588007541 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052588007542 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1052588007543 YodA lipocalin-like domain; Region: YodA; pfam09223 1052588007544 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 1052588007545 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588007546 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588007547 DNA binding residues [nucleotide binding] 1052588007548 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588007549 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052588007550 active site 1052588007551 catalytic tetrad [active] 1052588007552 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1052588007553 chitosan binding site [chemical binding]; other site 1052588007554 catalytic residues [active] 1052588007555 Mor transcription activator family; Region: Mor; cl02360 1052588007556 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052588007557 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052588007558 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1052588007559 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1052588007560 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1052588007561 Bacterial SH3 domain; Region: SH3_3; cl17532 1052588007562 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588007563 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052588007564 active site 1052588007565 metal binding site [ion binding]; metal-binding site 1052588007566 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1052588007567 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1052588007568 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052588007569 NAD binding site [chemical binding]; other site 1052588007570 catalytic Zn binding site [ion binding]; other site 1052588007571 structural Zn binding site [ion binding]; other site 1052588007572 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1052588007573 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052588007574 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1052588007575 DNA binding residues [nucleotide binding] 1052588007576 putative dimer interface [polypeptide binding]; other site 1052588007577 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1052588007578 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1052588007579 putative NAD(P) binding site [chemical binding]; other site 1052588007580 putative substrate binding site [chemical binding]; other site 1052588007581 catalytic Zn binding site [ion binding]; other site 1052588007582 structural Zn binding site [ion binding]; other site 1052588007583 dimer interface [polypeptide binding]; other site 1052588007584 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1052588007585 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1052588007586 proposed catalytic triad [active] 1052588007587 conserved cys residue [active] 1052588007588 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1052588007589 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052588007590 substrate binding [chemical binding]; other site 1052588007591 active site 1052588007592 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052588007593 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1052588007594 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 1052588007595 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1052588007596 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1052588007597 active site 1052588007598 phosphorylation site [posttranslational modification] 1052588007599 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1052588007600 active pocket/dimerization site; other site 1052588007601 active site 1052588007602 phosphorylation site [posttranslational modification] 1052588007603 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1052588007604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588007605 Walker A motif; other site 1052588007606 ATP binding site [chemical binding]; other site 1052588007607 Walker B motif; other site 1052588007608 arginine finger; other site 1052588007609 Transcriptional antiterminator [Transcription]; Region: COG3933 1052588007610 PRD domain; Region: PRD; pfam00874 1052588007611 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1052588007612 active pocket/dimerization site; other site 1052588007613 active site 1052588007614 phosphorylation site [posttranslational modification] 1052588007615 PRD domain; Region: PRD; pfam00874 1052588007616 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052588007617 LysE type translocator; Region: LysE; cl00565 1052588007618 Predicted transcriptional regulators [Transcription]; Region: COG1378 1052588007619 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1052588007620 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1052588007621 C-terminal domain interface [polypeptide binding]; other site 1052588007622 sugar binding site [chemical binding]; other site 1052588007623 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1052588007624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588007625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588007626 DNA binding residues [nucleotide binding] 1052588007627 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052588007628 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1052588007629 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1052588007630 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1052588007631 catalytic triad [active] 1052588007632 catalytic triad [active] 1052588007633 oxyanion hole [active] 1052588007634 YrhK-like protein; Region: YrhK; pfam14145 1052588007635 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052588007636 Cytochrome P450; Region: p450; pfam00067 1052588007637 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1052588007638 Flavodoxin; Region: Flavodoxin_1; pfam00258 1052588007639 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1052588007640 FAD binding pocket [chemical binding]; other site 1052588007641 FAD binding motif [chemical binding]; other site 1052588007642 catalytic residues [active] 1052588007643 NAD binding pocket [chemical binding]; other site 1052588007644 phosphate binding motif [ion binding]; other site 1052588007645 beta-alpha-beta structure motif; other site 1052588007646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588007647 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588007648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588007649 S-adenosylmethionine binding site [chemical binding]; other site 1052588007650 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1052588007651 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1052588007652 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1052588007653 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1052588007654 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1052588007655 catalytic loop [active] 1052588007656 iron binding site [ion binding]; other site 1052588007657 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1052588007658 4Fe-4S binding domain; Region: Fer4; pfam00037 1052588007659 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1052588007660 [4Fe-4S] binding site [ion binding]; other site 1052588007661 molybdopterin cofactor binding site; other site 1052588007662 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1052588007663 molybdopterin cofactor binding site; other site 1052588007664 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1052588007665 YrhC-like protein; Region: YrhC; pfam14143 1052588007666 cystathionine beta-lyase; Provisional; Region: PRK07671 1052588007667 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052588007668 homodimer interface [polypeptide binding]; other site 1052588007669 substrate-cofactor binding pocket; other site 1052588007670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588007671 catalytic residue [active] 1052588007672 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052588007673 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052588007674 dimer interface [polypeptide binding]; other site 1052588007675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588007676 catalytic residue [active] 1052588007677 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1052588007678 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1052588007679 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1052588007680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588007681 S-adenosylmethionine binding site [chemical binding]; other site 1052588007682 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1052588007683 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1052588007684 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052588007685 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588007686 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052588007687 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1052588007688 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1052588007689 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1052588007690 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1052588007691 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1052588007692 ATP-binding site [chemical binding]; other site 1052588007693 Sugar specificity; other site 1052588007694 Pyrimidine base specificity; other site 1052588007695 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1052588007696 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1052588007697 Peptidase family U32; Region: Peptidase_U32; pfam01136 1052588007698 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1052588007699 Peptidase family U32; Region: Peptidase_U32; pfam01136 1052588007700 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1052588007701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588007702 S-adenosylmethionine binding site [chemical binding]; other site 1052588007703 conserved hypothetical protein, YceG family; Region: TIGR00247 1052588007704 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1052588007705 dimerization interface [polypeptide binding]; other site 1052588007706 hypothetical protein; Provisional; Region: PRK13678 1052588007707 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1052588007708 hypothetical protein; Provisional; Region: PRK05473 1052588007709 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1052588007710 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1052588007711 motif 1; other site 1052588007712 active site 1052588007713 motif 2; other site 1052588007714 motif 3; other site 1052588007715 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1052588007716 DHHA1 domain; Region: DHHA1; pfam02272 1052588007717 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1052588007718 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052588007719 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052588007720 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052588007721 Walker A/P-loop; other site 1052588007722 ATP binding site [chemical binding]; other site 1052588007723 Q-loop/lid; other site 1052588007724 ABC transporter signature motif; other site 1052588007725 Walker B; other site 1052588007726 D-loop; other site 1052588007727 H-loop/switch region; other site 1052588007728 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1052588007729 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052588007730 substrate binding pocket [chemical binding]; other site 1052588007731 membrane-bound complex binding site; other site 1052588007732 hinge residues; other site 1052588007733 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052588007734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588007735 dimer interface [polypeptide binding]; other site 1052588007736 conserved gate region; other site 1052588007737 putative PBP binding loops; other site 1052588007738 ABC-ATPase subunit interface; other site 1052588007739 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1052588007740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588007741 dimer interface [polypeptide binding]; other site 1052588007742 ABC-ATPase subunit interface; other site 1052588007743 putative PBP binding loops; other site 1052588007744 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 1052588007745 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1052588007746 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1052588007747 AAA domain; Region: AAA_30; pfam13604 1052588007748 Family description; Region: UvrD_C_2; pfam13538 1052588007749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588007750 binding surface 1052588007751 TPR motif; other site 1052588007752 TPR repeat; Region: TPR_11; pfam13414 1052588007753 TPR repeat; Region: TPR_11; pfam13414 1052588007754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588007755 binding surface 1052588007756 TPR motif; other site 1052588007757 TPR repeat; Region: TPR_11; pfam13414 1052588007758 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1052588007759 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1052588007760 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1052588007761 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1052588007762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588007763 catalytic residue [active] 1052588007764 Predicted transcriptional regulator [Transcription]; Region: COG1959 1052588007765 Transcriptional regulator; Region: Rrf2; pfam02082 1052588007766 recombination factor protein RarA; Reviewed; Region: PRK13342 1052588007767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588007768 Walker A motif; other site 1052588007769 ATP binding site [chemical binding]; other site 1052588007770 Walker B motif; other site 1052588007771 arginine finger; other site 1052588007772 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1052588007773 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1052588007774 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1052588007775 putative ATP binding site [chemical binding]; other site 1052588007776 putative substrate interface [chemical binding]; other site 1052588007777 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1052588007778 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1052588007779 dimer interface [polypeptide binding]; other site 1052588007780 anticodon binding site; other site 1052588007781 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1052588007782 homodimer interface [polypeptide binding]; other site 1052588007783 motif 1; other site 1052588007784 active site 1052588007785 motif 2; other site 1052588007786 GAD domain; Region: GAD; pfam02938 1052588007787 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1052588007788 motif 3; other site 1052588007789 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1052588007790 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1052588007791 dimer interface [polypeptide binding]; other site 1052588007792 motif 1; other site 1052588007793 active site 1052588007794 motif 2; other site 1052588007795 motif 3; other site 1052588007796 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1052588007797 anticodon binding site; other site 1052588007798 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1052588007799 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1052588007800 Bacterial SH3 domain; Region: SH3_3; pfam08239 1052588007801 Bacterial SH3 domain; Region: SH3_3; pfam08239 1052588007802 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1052588007803 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1052588007804 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052588007805 active site 1052588007806 metal binding site [ion binding]; metal-binding site 1052588007807 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1052588007808 putative active site [active] 1052588007809 dimerization interface [polypeptide binding]; other site 1052588007810 putative tRNAtyr binding site [nucleotide binding]; other site 1052588007811 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1052588007812 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052588007813 Zn2+ binding site [ion binding]; other site 1052588007814 Mg2+ binding site [ion binding]; other site 1052588007815 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052588007816 synthetase active site [active] 1052588007817 NTP binding site [chemical binding]; other site 1052588007818 metal binding site [ion binding]; metal-binding site 1052588007819 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1052588007820 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1052588007821 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588007822 active site 1052588007823 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1052588007824 DHH family; Region: DHH; pfam01368 1052588007825 DHHA1 domain; Region: DHHA1; pfam02272 1052588007826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1052588007827 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1052588007828 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1052588007829 TrkA-C domain; Region: TrkA_C; pfam02080 1052588007830 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1052588007831 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1052588007832 RDD family; Region: RDD; pfam06271 1052588007833 Protein export membrane protein; Region: SecD_SecF; pfam02355 1052588007834 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1052588007835 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1052588007836 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1052588007837 Predicted membrane protein [Function unknown]; Region: COG2323 1052588007838 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1052588007839 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1052588007840 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1052588007841 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1052588007842 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1052588007843 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1052588007844 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1052588007845 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1052588007846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588007847 Walker A motif; other site 1052588007848 ATP binding site [chemical binding]; other site 1052588007849 Walker B motif; other site 1052588007850 arginine finger; other site 1052588007851 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1052588007852 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1052588007853 RuvA N terminal domain; Region: RuvA_N; pfam01330 1052588007854 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1052588007855 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1052588007856 BofC C-terminal domain; Region: BofC_C; pfam08955 1052588007857 polyol permease family; Region: 2A0118; TIGR00897 1052588007858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588007859 putative substrate translocation pore; other site 1052588007860 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588007861 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052588007862 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052588007863 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1052588007864 active site 1052588007865 substrate binding site [chemical binding]; other site 1052588007866 ATP binding site [chemical binding]; other site 1052588007867 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052588007868 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1052588007869 hypothetical protein; Validated; Region: PRK00110 1052588007870 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052588007871 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588007872 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1052588007873 quinolinate synthetase complex, A subunit; Region: nadA; TIGR00550 1052588007874 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1052588007875 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1052588007876 dimerization interface [polypeptide binding]; other site 1052588007877 active site 1052588007878 L-aspartate oxidase; Provisional; Region: PRK08071 1052588007879 L-aspartate oxidase; Provisional; Region: PRK06175 1052588007880 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1052588007881 cysteine desulfurase; Provisional; Region: PRK02948 1052588007882 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1052588007883 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588007884 catalytic residue [active] 1052588007885 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1052588007886 HTH domain; Region: HTH_11; pfam08279 1052588007887 3H domain; Region: 3H; pfam02829 1052588007888 prephenate dehydratase; Provisional; Region: PRK11898 1052588007889 Prephenate dehydratase; Region: PDT; pfam00800 1052588007890 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1052588007891 putative L-Phe binding site [chemical binding]; other site 1052588007892 hypothetical protein; Provisional; Region: PRK04435 1052588007893 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1052588007894 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1052588007895 GTP1/OBG; Region: GTP1_OBG; pfam01018 1052588007896 Obg GTPase; Region: Obg; cd01898 1052588007897 G1 box; other site 1052588007898 GTP/Mg2+ binding site [chemical binding]; other site 1052588007899 Switch I region; other site 1052588007900 G2 box; other site 1052588007901 G3 box; other site 1052588007902 Switch II region; other site 1052588007903 G4 box; other site 1052588007904 G5 box; other site 1052588007905 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1052588007906 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052588007907 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1052588007908 hypothetical protein; Provisional; Region: PRK14553 1052588007909 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1052588007910 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1052588007911 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1052588007912 active site 1052588007913 Peptidase family M50; Region: Peptidase_M50; pfam02163 1052588007914 putative substrate binding region [chemical binding]; other site 1052588007915 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1052588007916 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052588007917 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1052588007918 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1052588007919 Switch I; other site 1052588007920 Switch II; other site 1052588007921 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1052588007922 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1052588007923 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1052588007924 rod shape-determining protein MreC; Region: mreC; TIGR00219 1052588007925 rod shape-determining protein MreC; Region: MreC; pfam04085 1052588007926 rod shape-determining protein MreB; Provisional; Region: PRK13927 1052588007927 MreB and similar proteins; Region: MreB_like; cd10225 1052588007928 nucleotide binding site [chemical binding]; other site 1052588007929 Mg binding site [ion binding]; other site 1052588007930 putative protofilament interaction site [polypeptide binding]; other site 1052588007931 RodZ interaction site [polypeptide binding]; other site 1052588007932 hypothetical protein; Reviewed; Region: PRK00024 1052588007933 Helix-hairpin-helix motif; Region: HHH; pfam00633 1052588007934 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1052588007935 MPN+ (JAMM) motif; other site 1052588007936 Zinc-binding site [ion binding]; other site 1052588007937 Maf-like protein; Region: Maf; pfam02545 1052588007938 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1052588007939 active site 1052588007940 dimer interface [polypeptide binding]; other site 1052588007941 Sporulation related domain; Region: SPOR; pfam05036 1052588007942 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1052588007943 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1052588007944 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1052588007945 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1052588007946 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052588007947 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052588007948 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1052588007949 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052588007950 active site 1052588007951 HIGH motif; other site 1052588007952 nucleotide binding site [chemical binding]; other site 1052588007953 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1052588007954 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1052588007955 active site 1052588007956 KMSKS motif; other site 1052588007957 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1052588007958 tRNA binding surface [nucleotide binding]; other site 1052588007959 anticodon binding site; other site 1052588007960 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1052588007961 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1052588007962 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1052588007963 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588007964 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1052588007965 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588007966 inhibitor-cofactor binding pocket; inhibition site 1052588007967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588007968 catalytic residue [active] 1052588007969 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1052588007970 dimer interface [polypeptide binding]; other site 1052588007971 active site 1052588007972 Schiff base residues; other site 1052588007973 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1052588007974 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052588007975 active site 1052588007976 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1052588007977 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1052588007978 domain interfaces; other site 1052588007979 active site 1052588007980 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1052588007981 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1052588007982 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1052588007983 tRNA; other site 1052588007984 putative tRNA binding site [nucleotide binding]; other site 1052588007985 putative NADP binding site [chemical binding]; other site 1052588007986 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1052588007987 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1052588007988 G1 box; other site 1052588007989 GTP/Mg2+ binding site [chemical binding]; other site 1052588007990 Switch I region; other site 1052588007991 G2 box; other site 1052588007992 G3 box; other site 1052588007993 Switch II region; other site 1052588007994 G4 box; other site 1052588007995 G5 box; other site 1052588007996 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1052588007997 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1052588007998 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1052588007999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588008000 Walker A motif; other site 1052588008001 ATP binding site [chemical binding]; other site 1052588008002 Walker B motif; other site 1052588008003 arginine finger; other site 1052588008004 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1052588008005 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1052588008006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588008007 Walker A motif; other site 1052588008008 ATP binding site [chemical binding]; other site 1052588008009 Walker B motif; other site 1052588008010 arginine finger; other site 1052588008011 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1052588008012 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1052588008013 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1052588008014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588008015 Walker A motif; other site 1052588008016 ATP binding site [chemical binding]; other site 1052588008017 Walker B motif; other site 1052588008018 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1052588008019 trigger factor; Provisional; Region: tig; PRK01490 1052588008020 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1052588008021 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1052588008022 TPR repeat; Region: TPR_11; pfam13414 1052588008023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588008024 binding surface 1052588008025 TPR motif; other site 1052588008026 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1052588008027 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1052588008028 substrate binding site [chemical binding]; other site 1052588008029 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1052588008030 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1052588008031 substrate binding site [chemical binding]; other site 1052588008032 ligand binding site [chemical binding]; other site 1052588008033 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1052588008034 tartrate dehydrogenase; Region: TTC; TIGR02089 1052588008035 2-isopropylmalate synthase; Validated; Region: PRK00915 1052588008036 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1052588008037 active site 1052588008038 metal binding site [ion binding]; metal-binding site 1052588008039 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1052588008040 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1052588008041 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1052588008042 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1052588008043 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1052588008044 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1052588008045 putative valine binding site [chemical binding]; other site 1052588008046 dimer interface [polypeptide binding]; other site 1052588008047 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1052588008048 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1052588008049 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052588008050 PYR/PP interface [polypeptide binding]; other site 1052588008051 dimer interface [polypeptide binding]; other site 1052588008052 TPP binding site [chemical binding]; other site 1052588008053 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1052588008054 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1052588008055 TPP-binding site [chemical binding]; other site 1052588008056 dimer interface [polypeptide binding]; other site 1052588008057 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052588008058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588008059 Coenzyme A binding pocket [chemical binding]; other site 1052588008060 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1052588008061 Kelch motif; Region: Kelch_1; pfam01344 1052588008062 Kelch motif; Region: Kelch_1; pfam01344 1052588008063 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1052588008064 Kelch motif; Region: Kelch_1; pfam01344 1052588008065 Heat induced stress protein YflT; Region: YflT; pfam11181 1052588008066 conserved domain; Region: TIGR02271 1052588008067 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1052588008068 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052588008069 active site 1052588008070 metal binding site [ion binding]; metal-binding site 1052588008071 homotetramer interface [polypeptide binding]; other site 1052588008072 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1052588008073 active site 1052588008074 dimerization interface [polypeptide binding]; other site 1052588008075 ribonuclease PH; Reviewed; Region: rph; PRK00173 1052588008076 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1052588008077 hexamer interface [polypeptide binding]; other site 1052588008078 active site 1052588008079 Spore germination protein [General function prediction only]; Region: COG5401 1052588008080 Sporulation and spore germination; Region: Germane; pfam10646 1052588008081 Sporulation and spore germination; Region: Germane; pfam10646 1052588008082 glutamate racemase; Region: glut_race; TIGR00067 1052588008083 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588008084 MarR family; Region: MarR; pfam01047 1052588008085 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588008086 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588008087 DNA binding residues [nucleotide binding] 1052588008088 dimerization interface [polypeptide binding]; other site 1052588008089 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1052588008090 active site 1052588008091 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1052588008092 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1052588008093 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1052588008094 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1052588008095 L-aspartate oxidase; Provisional; Region: PRK06175 1052588008096 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1052588008097 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1052588008098 putative Iron-sulfur protein interface [polypeptide binding]; other site 1052588008099 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1052588008100 proximal heme binding site [chemical binding]; other site 1052588008101 distal heme binding site [chemical binding]; other site 1052588008102 putative dimer interface [polypeptide binding]; other site 1052588008103 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1052588008104 aspartate kinase; Reviewed; Region: PRK06635 1052588008105 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1052588008106 putative nucleotide binding site [chemical binding]; other site 1052588008107 putative catalytic residues [active] 1052588008108 putative Mg ion binding site [ion binding]; other site 1052588008109 putative aspartate binding site [chemical binding]; other site 1052588008110 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1052588008111 putative allosteric regulatory site; other site 1052588008112 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1052588008113 putative allosteric regulatory residue; other site 1052588008114 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1052588008115 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1052588008116 GIY-YIG motif/motif A; other site 1052588008117 active site 1052588008118 catalytic site [active] 1052588008119 putative DNA binding site [nucleotide binding]; other site 1052588008120 metal binding site [ion binding]; metal-binding site 1052588008121 UvrB/uvrC motif; Region: UVR; pfam02151 1052588008122 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1052588008123 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052588008124 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052588008125 catalytic residues [active] 1052588008126 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1052588008127 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1052588008128 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1052588008129 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1052588008130 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1052588008131 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1052588008132 Ligand binding site [chemical binding]; other site 1052588008133 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1052588008134 enoyl-CoA hydratase; Provisional; Region: PRK07658 1052588008135 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588008136 substrate binding site [chemical binding]; other site 1052588008137 oxyanion hole (OAH) forming residues; other site 1052588008138 trimer interface [polypeptide binding]; other site 1052588008139 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588008140 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588008141 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1052588008142 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1052588008143 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1052588008144 acyl-activating enzyme (AAE) consensus motif; other site 1052588008145 putative AMP binding site [chemical binding]; other site 1052588008146 putative active site [active] 1052588008147 putative CoA binding site [chemical binding]; other site 1052588008148 Predicted membrane protein [Function unknown]; Region: COG3766 1052588008149 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1052588008150 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1052588008151 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1052588008152 MutS domain III; Region: MutS_III; pfam05192 1052588008153 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1052588008154 Walker A/P-loop; other site 1052588008155 ATP binding site [chemical binding]; other site 1052588008156 Q-loop/lid; other site 1052588008157 ABC transporter signature motif; other site 1052588008158 Walker B; other site 1052588008159 D-loop; other site 1052588008160 H-loop/switch region; other site 1052588008161 Smr domain; Region: Smr; pfam01713 1052588008162 hypothetical protein; Provisional; Region: PRK08609 1052588008163 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1052588008164 active site 1052588008165 primer binding site [nucleotide binding]; other site 1052588008166 NTP binding site [chemical binding]; other site 1052588008167 metal binding triad [ion binding]; metal-binding site 1052588008168 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1052588008169 active site 1052588008170 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1052588008171 Colicin V production protein; Region: Colicin_V; pfam02674 1052588008172 cell division protein ZapA; Provisional; Region: PRK14126 1052588008173 ribonuclease HIII; Provisional; Region: PRK00996 1052588008174 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1052588008175 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1052588008176 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052588008177 active site 1052588008178 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1052588008179 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1052588008180 putative tRNA-binding site [nucleotide binding]; other site 1052588008181 B3/4 domain; Region: B3_4; pfam03483 1052588008182 tRNA synthetase B5 domain; Region: B5; smart00874 1052588008183 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1052588008184 dimer interface [polypeptide binding]; other site 1052588008185 motif 1; other site 1052588008186 motif 3; other site 1052588008187 motif 2; other site 1052588008188 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1052588008189 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1052588008190 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1052588008191 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1052588008192 dimer interface [polypeptide binding]; other site 1052588008193 motif 1; other site 1052588008194 active site 1052588008195 motif 2; other site 1052588008196 motif 3; other site 1052588008197 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1052588008198 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1052588008199 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1052588008200 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1052588008201 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1052588008202 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1052588008203 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1052588008204 FAD binding domain; Region: FAD_binding_4; pfam01565 1052588008205 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1052588008206 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1052588008207 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1052588008208 Cysteine-rich domain; Region: CCG; pfam02754 1052588008209 Cysteine-rich domain; Region: CCG; pfam02754 1052588008210 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1052588008211 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588008212 active site 1052588008213 metal binding site [ion binding]; metal-binding site 1052588008214 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1052588008215 Carbon starvation protein CstA; Region: CstA; pfam02554 1052588008216 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1052588008217 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1052588008218 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1052588008219 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052588008220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588008221 dimer interface [polypeptide binding]; other site 1052588008222 conserved gate region; other site 1052588008223 putative PBP binding loops; other site 1052588008224 ABC-ATPase subunit interface; other site 1052588008225 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052588008226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588008227 dimer interface [polypeptide binding]; other site 1052588008228 conserved gate region; other site 1052588008229 putative PBP binding loops; other site 1052588008230 ABC-ATPase subunit interface; other site 1052588008231 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052588008232 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052588008233 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1052588008234 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1052588008235 active site 1052588008236 metal binding site [ion binding]; metal-binding site 1052588008237 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1052588008238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588008239 active site 1052588008240 motif I; other site 1052588008241 motif II; other site 1052588008242 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588008243 motif II; other site 1052588008244 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1052588008245 L-ribulose-5-phosphate 4-epimerase; Region: araD; TIGR00760 1052588008246 intersubunit interface [polypeptide binding]; other site 1052588008247 active site 1052588008248 Zn2+ binding site [ion binding]; other site 1052588008249 L-ribulokinase; Region: L-ribulokinase; TIGR01234 1052588008250 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1052588008251 N- and C-terminal domain interface [polypeptide binding]; other site 1052588008252 active site 1052588008253 MgATP binding site [chemical binding]; other site 1052588008254 catalytic site [active] 1052588008255 metal binding site [ion binding]; metal-binding site 1052588008256 carbohydrate binding site [chemical binding]; other site 1052588008257 homodimer interface [polypeptide binding]; other site 1052588008258 L-arabinose isomerase; Provisional; Region: PRK02929 1052588008259 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1052588008260 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052588008261 trimer interface [polypeptide binding]; other site 1052588008262 putative substrate binding site [chemical binding]; other site 1052588008263 putative metal binding site [ion binding]; other site 1052588008264 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1052588008265 substrate binding site [chemical binding]; other site 1052588008266 active site 1052588008267 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052588008268 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1052588008269 oligomer interface [polypeptide binding]; other site 1052588008270 active site 1052588008271 metal binding site [ion binding]; metal-binding site 1052588008272 Predicted membrane protein [Function unknown]; Region: COG3326 1052588008273 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1052588008274 23S rRNA binding site [nucleotide binding]; other site 1052588008275 L21 binding site [polypeptide binding]; other site 1052588008276 L13 binding site [polypeptide binding]; other site 1052588008277 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1052588008278 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1052588008279 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1052588008280 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1052588008281 antiholin-like protein LrgB; Provisional; Region: PRK04288 1052588008282 LrgA family; Region: LrgA; cl00608 1052588008283 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1052588008284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588008285 active site 1052588008286 phosphorylation site [posttranslational modification] 1052588008287 intermolecular recognition site; other site 1052588008288 dimerization interface [polypeptide binding]; other site 1052588008289 LytTr DNA-binding domain; Region: LytTR; pfam04397 1052588008290 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1052588008291 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1052588008292 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1052588008293 Histidine kinase; Region: His_kinase; pfam06580 1052588008294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588008295 ATP binding site [chemical binding]; other site 1052588008296 Mg2+ binding site [ion binding]; other site 1052588008297 G-X-G motif; other site 1052588008298 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1052588008299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588008300 motif II; other site 1052588008301 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1052588008302 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1052588008303 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1052588008304 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1052588008305 active site 1052588008306 dimer interface [polypeptide binding]; other site 1052588008307 motif 1; other site 1052588008308 motif 2; other site 1052588008309 motif 3; other site 1052588008310 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1052588008311 anticodon binding site; other site 1052588008312 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1052588008313 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052588008314 primosomal protein DnaI; Reviewed; Region: PRK08939 1052588008315 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1052588008316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588008317 Walker A motif; other site 1052588008318 ATP binding site [chemical binding]; other site 1052588008319 Walker B motif; other site 1052588008320 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1052588008321 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1052588008322 ATP cone domain; Region: ATP-cone; pfam03477 1052588008323 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1052588008324 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1052588008325 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1052588008326 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1052588008327 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052588008328 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052588008329 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588008330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588008331 putative substrate translocation pore; other site 1052588008332 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588008333 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052588008334 active site 1052588008335 catalytic tetrad [active] 1052588008336 dephospho-CoA kinase; Region: TIGR00152 1052588008337 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1052588008338 CoA-binding site [chemical binding]; other site 1052588008339 ATP-binding [chemical binding]; other site 1052588008340 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1052588008341 Domain of unknown function DUF; Region: DUF204; pfam02659 1052588008342 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1052588008343 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1052588008344 DNA binding site [nucleotide binding] 1052588008345 catalytic residue [active] 1052588008346 H2TH interface [polypeptide binding]; other site 1052588008347 putative catalytic residues [active] 1052588008348 turnover-facilitating residue; other site 1052588008349 intercalation triad [nucleotide binding]; other site 1052588008350 8OG recognition residue [nucleotide binding]; other site 1052588008351 putative reading head residues; other site 1052588008352 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1052588008353 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1052588008354 DNA polymerase I; Provisional; Region: PRK05755 1052588008355 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1052588008356 active site 1052588008357 metal binding site 1 [ion binding]; metal-binding site 1052588008358 putative 5' ssDNA interaction site; other site 1052588008359 metal binding site 3; metal-binding site 1052588008360 metal binding site 2 [ion binding]; metal-binding site 1052588008361 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1052588008362 putative DNA binding site [nucleotide binding]; other site 1052588008363 putative metal binding site [ion binding]; other site 1052588008364 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1052588008365 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1052588008366 active site 1052588008367 DNA binding site [nucleotide binding] 1052588008368 catalytic site [active] 1052588008369 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052588008370 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588008371 putative active site [active] 1052588008372 heme pocket [chemical binding]; other site 1052588008373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588008374 dimer interface [polypeptide binding]; other site 1052588008375 phosphorylation site [posttranslational modification] 1052588008376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588008377 ATP binding site [chemical binding]; other site 1052588008378 Mg2+ binding site [ion binding]; other site 1052588008379 G-X-G motif; other site 1052588008380 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588008381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588008382 active site 1052588008383 phosphorylation site [posttranslational modification] 1052588008384 intermolecular recognition site; other site 1052588008385 dimerization interface [polypeptide binding]; other site 1052588008386 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588008387 DNA binding site [nucleotide binding] 1052588008388 malate dehydrogenase; Reviewed; Region: PRK06223 1052588008389 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1052588008390 NAD(P) binding site [chemical binding]; other site 1052588008391 dimer interface [polypeptide binding]; other site 1052588008392 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588008393 substrate binding site [chemical binding]; other site 1052588008394 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1052588008395 isocitrate dehydrogenase; Validated; Region: PRK07362 1052588008396 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1052588008397 dimer interface [polypeptide binding]; other site 1052588008398 Citrate synthase; Region: Citrate_synt; pfam00285 1052588008399 active site 1052588008400 citrylCoA binding site [chemical binding]; other site 1052588008401 oxalacetate/citrate binding site [chemical binding]; other site 1052588008402 coenzyme A binding site [chemical binding]; other site 1052588008403 catalytic triad [active] 1052588008404 Predicted membrane protein [Function unknown]; Region: COG2707 1052588008405 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1052588008406 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052588008407 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1052588008408 pyruvate kinase; Provisional; Region: PRK06354 1052588008409 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1052588008410 domain interfaces; other site 1052588008411 active site 1052588008412 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1052588008413 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1052588008414 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1052588008415 active site 1052588008416 ADP/pyrophosphate binding site [chemical binding]; other site 1052588008417 dimerization interface [polypeptide binding]; other site 1052588008418 allosteric effector site; other site 1052588008419 fructose-1,6-bisphosphate binding site; other site 1052588008420 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1052588008421 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1052588008422 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1052588008423 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1052588008424 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1052588008425 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1052588008426 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052588008427 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1052588008428 putative NAD(P) binding site [chemical binding]; other site 1052588008429 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1052588008430 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1052588008431 active site 1052588008432 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1052588008433 generic binding surface I; other site 1052588008434 generic binding surface II; other site 1052588008435 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1052588008436 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1052588008437 DHH family; Region: DHH; pfam01368 1052588008438 DHHA1 domain; Region: DHHA1; pfam02272 1052588008439 YtpI-like protein; Region: YtpI; pfam14007 1052588008440 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1052588008441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588008442 DNA-binding site [nucleotide binding]; DNA binding site 1052588008443 DRTGG domain; Region: DRTGG; pfam07085 1052588008444 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1052588008445 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1052588008446 active site 2 [active] 1052588008447 active site 1 [active] 1052588008448 metal-dependent hydrolase; Provisional; Region: PRK00685 1052588008449 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1052588008450 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1052588008451 classical (c) SDRs; Region: SDR_c; cd05233 1052588008452 NAD(P) binding site [chemical binding]; other site 1052588008453 active site 1052588008454 argininosuccinate lyase; Provisional; Region: PRK00855 1052588008455 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1052588008456 active sites [active] 1052588008457 tetramer interface [polypeptide binding]; other site 1052588008458 argininosuccinate synthase; Provisional; Region: PRK13820 1052588008459 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1052588008460 ANP binding site [chemical binding]; other site 1052588008461 Substrate Binding Site II [chemical binding]; other site 1052588008462 Substrate Binding Site I [chemical binding]; other site 1052588008463 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1052588008464 MPT binding site; other site 1052588008465 trimer interface [polypeptide binding]; other site 1052588008466 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1052588008467 propionate/acetate kinase; Provisional; Region: PRK12379 1052588008468 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1052588008469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588008470 S-adenosylmethionine binding site [chemical binding]; other site 1052588008471 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1052588008472 dimer interface [polypeptide binding]; other site 1052588008473 catalytic triad [active] 1052588008474 peroxidatic and resolving cysteines [active] 1052588008475 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1052588008476 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1052588008477 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1052588008478 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1052588008479 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1052588008480 tandem repeat interface [polypeptide binding]; other site 1052588008481 oligomer interface [polypeptide binding]; other site 1052588008482 active site residues [active] 1052588008483 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1052588008484 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1052588008485 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1052588008486 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1052588008487 active site 1052588008488 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1052588008489 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1052588008490 active site 1052588008491 acyl-activating enzyme (AAE) consensus motif; other site 1052588008492 putative CoA binding site [chemical binding]; other site 1052588008493 AMP binding site [chemical binding]; other site 1052588008494 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052588008495 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1052588008496 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1052588008497 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1052588008498 Ligand Binding Site [chemical binding]; other site 1052588008499 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1052588008500 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1052588008501 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588008502 catalytic residue [active] 1052588008503 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1052588008504 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1052588008505 histidinol-phosphatase; Reviewed; Region: PRK08123 1052588008506 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1052588008507 active site 1052588008508 dimer interface [polypeptide binding]; other site 1052588008509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588008510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588008511 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1052588008512 GAF domain; Region: GAF_2; pfam13185 1052588008513 GAF domain; Region: GAF_3; pfam13492 1052588008514 GAF domain; Region: GAF; cl17456 1052588008515 GAF domain; Region: GAF_2; pfam13185 1052588008516 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052588008517 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052588008518 metal binding site [ion binding]; metal-binding site 1052588008519 active site 1052588008520 I-site; other site 1052588008521 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1052588008522 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1052588008523 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588008524 RNA binding surface [nucleotide binding]; other site 1052588008525 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1052588008526 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1052588008527 active site 1052588008528 HIGH motif; other site 1052588008529 dimer interface [polypeptide binding]; other site 1052588008530 KMSKS motif; other site 1052588008531 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588008532 RNA binding surface [nucleotide binding]; other site 1052588008533 acetyl-CoA synthetase; Provisional; Region: PRK04319 1052588008534 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1052588008535 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1052588008536 active site 1052588008537 acyl-activating enzyme (AAE) consensus motif; other site 1052588008538 putative CoA binding site [chemical binding]; other site 1052588008539 AMP binding site [chemical binding]; other site 1052588008540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588008541 Coenzyme A binding pocket [chemical binding]; other site 1052588008542 FOG: CBS domain [General function prediction only]; Region: COG0517 1052588008543 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1052588008544 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1052588008545 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1052588008546 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1052588008547 active site 1052588008548 Zn binding site [ion binding]; other site 1052588008549 flagellar motor protein MotS; Reviewed; Region: PRK06925 1052588008550 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1052588008551 ligand binding site [chemical binding]; other site 1052588008552 flagellar motor protein MotP; Reviewed; Region: PRK06926 1052588008553 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1052588008554 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1052588008555 dimerization interface [polypeptide binding]; other site 1052588008556 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1052588008557 effector binding site; other site 1052588008558 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1052588008559 chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801 1052588008560 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1052588008561 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 1052588008562 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1052588008563 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1052588008564 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1052588008565 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1052588008566 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052588008567 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052588008568 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1052588008569 putative tRNA-binding site [nucleotide binding]; other site 1052588008570 hypothetical protein; Provisional; Region: PRK13668 1052588008571 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052588008572 catalytic residues [active] 1052588008573 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1052588008574 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052588008575 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1052588008576 oligomer interface [polypeptide binding]; other site 1052588008577 active site 1052588008578 metal binding site [ion binding]; metal-binding site 1052588008579 Predicted small secreted protein [Function unknown]; Region: COG5584 1052588008580 malate dehydrogenase; Provisional; Region: PRK13529 1052588008581 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052588008582 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1052588008583 NAD(P) binding site [chemical binding]; other site 1052588008584 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1052588008585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588008586 S-adenosylmethionine binding site [chemical binding]; other site 1052588008587 YtzH-like protein; Region: YtzH; pfam14165 1052588008588 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1052588008589 active site 1052588008590 ATP binding site [chemical binding]; other site 1052588008591 Phosphotransferase enzyme family; Region: APH; pfam01636 1052588008592 substrate binding site [chemical binding]; other site 1052588008593 pullulanase, type I; Region: pulA_typeI; TIGR02104 1052588008594 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1052588008595 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1052588008596 Ca binding site [ion binding]; other site 1052588008597 active site 1052588008598 catalytic site [active] 1052588008599 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1052588008600 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1052588008601 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1052588008602 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052588008603 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052588008604 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052588008605 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052588008606 dimer interface [polypeptide binding]; other site 1052588008607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588008608 catalytic residue [active] 1052588008609 dipeptidase PepV; Reviewed; Region: PRK07318 1052588008610 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1052588008611 active site 1052588008612 metal binding site [ion binding]; metal-binding site 1052588008613 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1052588008614 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1052588008615 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052588008616 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052588008617 Walker A/P-loop; other site 1052588008618 ATP binding site [chemical binding]; other site 1052588008619 Q-loop/lid; other site 1052588008620 ABC transporter signature motif; other site 1052588008621 Walker B; other site 1052588008622 D-loop; other site 1052588008623 H-loop/switch region; other site 1052588008624 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1052588008625 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1052588008626 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588008627 RNA binding surface [nucleotide binding]; other site 1052588008628 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1052588008629 active site 1052588008630 uracil binding [chemical binding]; other site 1052588008631 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052588008632 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1052588008633 Predicted flavoproteins [General function prediction only]; Region: COG2081 1052588008634 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052588008635 BCCT family transporter; Region: BCCT; pfam02028 1052588008636 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1052588008637 Predicted integral membrane protein [Function unknown]; Region: COG5578 1052588008638 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588008639 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052588008640 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052588008641 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1052588008642 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052588008643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588008644 dimer interface [polypeptide binding]; other site 1052588008645 conserved gate region; other site 1052588008646 ABC-ATPase subunit interface; other site 1052588008647 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1052588008648 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588008649 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588008650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588008651 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052588008652 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052588008653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588008654 dimer interface [polypeptide binding]; other site 1052588008655 conserved gate region; other site 1052588008656 putative PBP binding loops; other site 1052588008657 ABC-ATPase subunit interface; other site 1052588008658 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052588008659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008660 NAD(P) binding site [chemical binding]; other site 1052588008661 active site 1052588008662 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052588008663 Cytochrome P450; Region: p450; cl12078 1052588008664 biotin synthase; Validated; Region: PRK06256 1052588008665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588008666 FeS/SAM binding site; other site 1052588008667 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1052588008668 AAA domain; Region: AAA_26; pfam13500 1052588008669 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1052588008670 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1052588008671 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1052588008672 substrate-cofactor binding pocket; other site 1052588008673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588008674 catalytic residue [active] 1052588008675 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1052588008676 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588008677 inhibitor-cofactor binding pocket; inhibition site 1052588008678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588008679 catalytic residue [active] 1052588008680 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1052588008681 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1052588008682 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052588008683 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588008684 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588008685 DNA binding site [nucleotide binding] 1052588008686 domain linker motif; other site 1052588008687 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1052588008688 putative ligand binding site [chemical binding]; other site 1052588008689 putative dimerization interface [polypeptide binding]; other site 1052588008690 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052588008691 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1052588008692 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052588008693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588008694 dimer interface [polypeptide binding]; other site 1052588008695 conserved gate region; other site 1052588008696 putative PBP binding loops; other site 1052588008697 ABC-ATPase subunit interface; other site 1052588008698 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052588008699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588008700 dimer interface [polypeptide binding]; other site 1052588008701 conserved gate region; other site 1052588008702 putative PBP binding loops; other site 1052588008703 ABC-ATPase subunit interface; other site 1052588008704 alpha-galactosidase; Provisional; Region: PRK15076 1052588008705 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1052588008706 NAD binding site [chemical binding]; other site 1052588008707 sugar binding site [chemical binding]; other site 1052588008708 divalent metal binding site [ion binding]; other site 1052588008709 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588008710 dimer interface [polypeptide binding]; other site 1052588008711 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052588008712 active site residue [active] 1052588008713 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1052588008714 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1052588008715 HIGH motif; other site 1052588008716 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1052588008717 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052588008718 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1052588008719 active site 1052588008720 KMSKS motif; other site 1052588008721 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1052588008722 tRNA binding surface [nucleotide binding]; other site 1052588008723 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1052588008724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588008725 PAS domain; Region: PAS_9; pfam13426 1052588008726 putative active site [active] 1052588008727 heme pocket [chemical binding]; other site 1052588008728 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588008729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588008730 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588008731 putative substrate translocation pore; other site 1052588008732 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1052588008733 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1052588008734 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052588008735 FtsX-like permease family; Region: FtsX; pfam02687 1052588008736 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588008737 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052588008738 Walker A/P-loop; other site 1052588008739 ATP binding site [chemical binding]; other site 1052588008740 Q-loop/lid; other site 1052588008741 ABC transporter signature motif; other site 1052588008742 Walker B; other site 1052588008743 D-loop; other site 1052588008744 H-loop/switch region; other site 1052588008745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052588008746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588008747 ATP binding site [chemical binding]; other site 1052588008748 Mg2+ binding site [ion binding]; other site 1052588008749 G-X-G motif; other site 1052588008750 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588008751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588008752 active site 1052588008753 phosphorylation site [posttranslational modification] 1052588008754 intermolecular recognition site; other site 1052588008755 dimerization interface [polypeptide binding]; other site 1052588008756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588008757 DNA binding site [nucleotide binding] 1052588008758 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052588008759 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052588008760 FtsX-like permease family; Region: FtsX; pfam02687 1052588008761 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588008762 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052588008763 Walker A/P-loop; other site 1052588008764 ATP binding site [chemical binding]; other site 1052588008765 Q-loop/lid; other site 1052588008766 ABC transporter signature motif; other site 1052588008767 Walker B; other site 1052588008768 D-loop; other site 1052588008769 H-loop/switch region; other site 1052588008770 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1052588008771 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1052588008772 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052588008773 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052588008774 Walker A/P-loop; other site 1052588008775 ATP binding site [chemical binding]; other site 1052588008776 Q-loop/lid; other site 1052588008777 ABC transporter signature motif; other site 1052588008778 Walker B; other site 1052588008779 D-loop; other site 1052588008780 H-loop/switch region; other site 1052588008781 Predicted transcriptional regulators [Transcription]; Region: COG1725 1052588008782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588008783 DNA-binding site [nucleotide binding]; DNA binding site 1052588008784 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1052588008785 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1052588008786 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1052588008787 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1052588008788 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1052588008789 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052588008790 PGAP1-like protein; Region: PGAP1; pfam07819 1052588008791 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1052588008792 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1052588008793 trimer interface [polypeptide binding]; other site 1052588008794 putative metal binding site [ion binding]; other site 1052588008795 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052588008796 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1052588008797 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1052588008798 active site 1052588008799 dimer interface [polypeptide binding]; other site 1052588008800 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1052588008801 Ligand Binding Site [chemical binding]; other site 1052588008802 Molecular Tunnel; other site 1052588008803 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1052588008804 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1052588008805 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1052588008806 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1052588008807 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1052588008808 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1052588008809 active site 1052588008810 substrate-binding site [chemical binding]; other site 1052588008811 metal-binding site [ion binding] 1052588008812 ATP binding site [chemical binding]; other site 1052588008813 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1052588008814 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1052588008815 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052588008816 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1052588008817 NMT1-like family; Region: NMT1_2; pfam13379 1052588008818 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1052588008819 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1052588008820 Walker A/P-loop; other site 1052588008821 ATP binding site [chemical binding]; other site 1052588008822 Q-loop/lid; other site 1052588008823 ABC transporter signature motif; other site 1052588008824 Walker B; other site 1052588008825 D-loop; other site 1052588008826 H-loop/switch region; other site 1052588008827 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1052588008828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588008829 dimer interface [polypeptide binding]; other site 1052588008830 conserved gate region; other site 1052588008831 putative PBP binding loops; other site 1052588008832 ABC-ATPase subunit interface; other site 1052588008833 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1052588008834 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1052588008835 nudix motif; other site 1052588008836 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1052588008837 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1052588008838 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1052588008839 dimerization interface [polypeptide binding]; other site 1052588008840 DPS ferroxidase diiron center [ion binding]; other site 1052588008841 ion pore; other site 1052588008842 YtkA-like; Region: YtkA; pfam13115 1052588008843 S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664 1052588008844 Haemolytic domain; Region: Haemolytic; pfam01809 1052588008845 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1052588008846 active site clefts [active] 1052588008847 zinc binding site [ion binding]; other site 1052588008848 dimer interface [polypeptide binding]; other site 1052588008849 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1052588008850 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1052588008851 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1052588008852 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1052588008853 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1052588008854 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588008855 ABC-ATPase subunit interface; other site 1052588008856 dimer interface [polypeptide binding]; other site 1052588008857 putative PBP binding regions; other site 1052588008858 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1052588008859 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588008860 ABC-ATPase subunit interface; other site 1052588008861 dimer interface [polypeptide binding]; other site 1052588008862 putative PBP binding regions; other site 1052588008863 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1052588008864 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052588008865 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1052588008866 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1052588008867 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 1052588008868 metal binding site [ion binding]; metal-binding site 1052588008869 intersubunit interface [polypeptide binding]; other site 1052588008870 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1052588008871 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1052588008872 active site 1052588008873 octamer interface [polypeptide binding]; other site 1052588008874 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1052588008875 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1052588008876 acyl-activating enzyme (AAE) consensus motif; other site 1052588008877 putative AMP binding site [chemical binding]; other site 1052588008878 putative active site [active] 1052588008879 putative CoA binding site [chemical binding]; other site 1052588008880 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588008881 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052588008882 substrate binding site [chemical binding]; other site 1052588008883 oxyanion hole (OAH) forming residues; other site 1052588008884 trimer interface [polypeptide binding]; other site 1052588008885 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1052588008886 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1052588008887 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1052588008888 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1052588008889 dimer interface [polypeptide binding]; other site 1052588008890 tetramer interface [polypeptide binding]; other site 1052588008891 PYR/PP interface [polypeptide binding]; other site 1052588008892 TPP binding site [chemical binding]; other site 1052588008893 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1052588008894 TPP-binding site; other site 1052588008895 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1052588008896 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1052588008897 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 1052588008898 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052588008899 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1052588008900 active site 1052588008901 tetramer interface; other site 1052588008902 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1052588008903 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1052588008904 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052588008905 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1052588008906 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052588008907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008908 NAD(P) binding site [chemical binding]; other site 1052588008909 active site 1052588008910 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588008911 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052588008912 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1052588008913 spore coat protein YutH; Region: spore_yutH; TIGR02905 1052588008914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588008915 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052588008916 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1052588008917 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1052588008918 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 1052588008919 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1052588008920 homodimer interface [polypeptide binding]; other site 1052588008921 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1052588008922 active site pocket [active] 1052588008923 glycogen synthase; Provisional; Region: glgA; PRK00654 1052588008924 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1052588008925 ADP-binding pocket [chemical binding]; other site 1052588008926 homodimer interface [polypeptide binding]; other site 1052588008927 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1052588008928 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1052588008929 ligand binding site; other site 1052588008930 oligomer interface; other site 1052588008931 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1052588008932 dimer interface [polypeptide binding]; other site 1052588008933 N-terminal domain interface [polypeptide binding]; other site 1052588008934 sulfate 1 binding site; other site 1052588008935 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1052588008936 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1052588008937 ligand binding site; other site 1052588008938 oligomer interface; other site 1052588008939 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1052588008940 dimer interface [polypeptide binding]; other site 1052588008941 N-terminal domain interface [polypeptide binding]; other site 1052588008942 sulfate 1 binding site; other site 1052588008943 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 1052588008944 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1052588008945 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1052588008946 active site 1052588008947 catalytic site [active] 1052588008948 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1052588008949 Predicted membrane protein [Function unknown]; Region: COG3859 1052588008950 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052588008951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588008952 Coenzyme A binding pocket [chemical binding]; other site 1052588008953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1052588008954 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1052588008955 DinB superfamily; Region: DinB_2; pfam12867 1052588008956 MOSC domain; Region: MOSC; pfam03473 1052588008957 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1052588008958 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1052588008959 active site 1052588008960 NAD binding site [chemical binding]; other site 1052588008961 metal binding site [ion binding]; metal-binding site 1052588008962 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1052588008963 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1052588008964 tetramerization interface [polypeptide binding]; other site 1052588008965 NAD(P) binding site [chemical binding]; other site 1052588008966 catalytic residues [active] 1052588008967 Predicted transcriptional regulators [Transcription]; Region: COG1510 1052588008968 MarR family; Region: MarR_2; pfam12802 1052588008969 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052588008970 TrkA-N domain; Region: TrkA_N; pfam02254 1052588008971 TrkA-C domain; Region: TrkA_C; pfam02080 1052588008972 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1052588008973 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1052588008974 Predicted membrane protein [Function unknown]; Region: COG4682 1052588008975 yiaA/B two helix domain; Region: YiaAB; pfam05360 1052588008976 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1052588008977 SH3-like domain; Region: SH3_8; pfam13457 1052588008978 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588008979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588008980 putative substrate translocation pore; other site 1052588008981 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1052588008982 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1052588008983 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052588008984 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1052588008985 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588008986 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052588008987 L-rhamnose isomerase (RhaA); Region: RhaA; pfam06134 1052588008988 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1052588008989 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1052588008990 N- and C-terminal domain interface [polypeptide binding]; other site 1052588008991 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1052588008992 active site 1052588008993 putative catalytic site [active] 1052588008994 metal binding site [ion binding]; metal-binding site 1052588008995 ATP binding site [chemical binding]; other site 1052588008996 carbohydrate binding site [chemical binding]; other site 1052588008997 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052588008998 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1052588008999 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1052588009000 short chain dehydrogenase; Validated; Region: PRK08324 1052588009001 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1052588009002 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1052588009003 putative NAD(P) binding site [chemical binding]; other site 1052588009004 active site 1052588009005 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1052588009006 Cache domain; Region: Cache_1; pfam02743 1052588009007 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588009008 dimerization interface [polypeptide binding]; other site 1052588009009 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052588009010 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588009011 dimer interface [polypeptide binding]; other site 1052588009012 putative CheW interface [polypeptide binding]; other site 1052588009013 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588009014 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1052588009015 Cache domain; Region: Cache_1; pfam02743 1052588009016 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588009017 dimerization interface [polypeptide binding]; other site 1052588009018 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588009019 dimer interface [polypeptide binding]; other site 1052588009020 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1052588009021 putative CheW interface [polypeptide binding]; other site 1052588009022 Tar ligand binding domain homologue; Region: TarH; pfam02203 1052588009023 Cache domain; Region: Cache_1; pfam02743 1052588009024 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588009025 dimerization interface [polypeptide binding]; other site 1052588009026 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052588009027 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588009028 dimer interface [polypeptide binding]; other site 1052588009029 putative CheW interface [polypeptide binding]; other site 1052588009030 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1052588009031 Cache domain; Region: Cache_1; pfam02743 1052588009032 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588009033 dimerization interface [polypeptide binding]; other site 1052588009034 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052588009035 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588009036 dimer interface [polypeptide binding]; other site 1052588009037 putative CheW interface [polypeptide binding]; other site 1052588009038 transglutaminase; Provisional; Region: tgl; PRK03187 1052588009039 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1052588009040 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052588009041 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052588009042 Ca binding site [ion binding]; other site 1052588009043 active site 1052588009044 catalytic site [active] 1052588009045 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052588009046 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052588009047 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052588009048 Transporter associated domain; Region: CorC_HlyC; smart01091 1052588009049 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1052588009050 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1052588009051 Ion channel; Region: Ion_trans_2; pfam07885 1052588009052 TrkA-N domain; Region: TrkA_N; pfam02254 1052588009053 YugN-like family; Region: YugN; pfam08868 1052588009054 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1052588009055 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1052588009056 active site 1052588009057 dimer interface [polypeptide binding]; other site 1052588009058 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1052588009059 dimer interface [polypeptide binding]; other site 1052588009060 active site 1052588009061 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1052588009062 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1052588009063 dimer interface [polypeptide binding]; other site 1052588009064 active site 1052588009065 metal binding site [ion binding]; metal-binding site 1052588009066 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1052588009067 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1052588009068 dimer interface [polypeptide binding]; other site 1052588009069 active site 1052588009070 metal binding site [ion binding]; metal-binding site 1052588009071 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1052588009072 general stress protein 13; Validated; Region: PRK08059 1052588009073 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1052588009074 RNA binding site [nucleotide binding]; other site 1052588009075 hypothetical protein; Validated; Region: PRK07682 1052588009076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588009077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588009078 homodimer interface [polypeptide binding]; other site 1052588009079 catalytic residue [active] 1052588009080 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1052588009081 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1052588009082 AsnC family; Region: AsnC_trans_reg; pfam01037 1052588009083 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1052588009084 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588009085 nucleophilic elbow; other site 1052588009086 catalytic triad; other site 1052588009087 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1052588009088 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1052588009089 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588009090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588009091 homodimer interface [polypeptide binding]; other site 1052588009092 catalytic residue [active] 1052588009093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052588009094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588009095 dimer interface [polypeptide binding]; other site 1052588009096 phosphorylation site [posttranslational modification] 1052588009097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588009098 ATP binding site [chemical binding]; other site 1052588009099 Mg2+ binding site [ion binding]; other site 1052588009100 G-X-G motif; other site 1052588009101 Kinase associated protein B; Region: KapB; pfam08810 1052588009102 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1052588009103 active site 1052588009104 catalytic site [active] 1052588009105 substrate binding site [chemical binding]; other site 1052588009106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588009107 drug efflux system protein MdtG; Provisional; Region: PRK09874 1052588009108 putative substrate translocation pore; other site 1052588009109 Transglycosylase; Region: Transgly; pfam00912 1052588009110 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052588009111 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1052588009112 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1052588009113 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1052588009114 PAS domain; Region: PAS; smart00091 1052588009115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588009116 ATP binding site [chemical binding]; other site 1052588009117 G-X-G motif; other site 1052588009118 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052588009119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588009120 active site 1052588009121 phosphorylation site [posttranslational modification] 1052588009122 intermolecular recognition site; other site 1052588009123 dimerization interface [polypeptide binding]; other site 1052588009124 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1052588009125 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1052588009126 ligand binding site [chemical binding]; other site 1052588009127 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1052588009128 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1052588009129 Walker A/P-loop; other site 1052588009130 ATP binding site [chemical binding]; other site 1052588009131 Q-loop/lid; other site 1052588009132 ABC transporter signature motif; other site 1052588009133 Walker B; other site 1052588009134 D-loop; other site 1052588009135 H-loop/switch region; other site 1052588009136 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1052588009137 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1052588009138 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1052588009139 TM-ABC transporter signature motif; other site 1052588009140 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1052588009141 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1052588009142 TM-ABC transporter signature motif; other site 1052588009143 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1052588009144 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1052588009145 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1052588009146 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1052588009147 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1052588009148 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1052588009149 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1052588009150 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1052588009151 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1052588009152 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1052588009153 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1052588009154 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1052588009155 CoenzymeA binding site [chemical binding]; other site 1052588009156 subunit interaction site [polypeptide binding]; other site 1052588009157 PHB binding site; other site 1052588009158 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588009159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588009160 active site 1052588009161 phosphorylation site [posttranslational modification] 1052588009162 intermolecular recognition site; other site 1052588009163 dimerization interface [polypeptide binding]; other site 1052588009164 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588009165 DNA binding residues [nucleotide binding] 1052588009166 dimerization interface [polypeptide binding]; other site 1052588009167 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 1052588009168 protein binding site [polypeptide binding]; other site 1052588009169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588009170 Histidine kinase; Region: HisKA_3; pfam07730 1052588009171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588009172 ATP binding site [chemical binding]; other site 1052588009173 Mg2+ binding site [ion binding]; other site 1052588009174 G-X-G motif; other site 1052588009175 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1052588009176 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1052588009177 substrate binding pocket [chemical binding]; other site 1052588009178 substrate-Mg2+ binding site; other site 1052588009179 aspartate-rich region 1; other site 1052588009180 aspartate-rich region 2; other site 1052588009181 DegQ (SacQ) family; Region: DegQ; pfam08181 1052588009182 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1052588009183 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1052588009184 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1052588009185 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1052588009186 active site 1052588009187 Isochorismatase family; Region: Isochorismatase; pfam00857 1052588009188 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1052588009189 catalytic triad [active] 1052588009190 conserved cis-peptide bond; other site 1052588009191 Uncharacterized conserved protein [Function unknown]; Region: COG5506 1052588009192 YueH-like protein; Region: YueH; pfam14166 1052588009193 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588009194 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1052588009195 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052588009196 Uncharacterized conserved small protein [Function unknown]; Region: COG5428 1052588009197 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1052588009198 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052588009199 Zn2+ binding site [ion binding]; other site 1052588009200 Mg2+ binding site [ion binding]; other site 1052588009201 short chain dehydrogenase; Provisional; Region: PRK06924 1052588009202 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1052588009203 NADP binding site [chemical binding]; other site 1052588009204 homodimer interface [polypeptide binding]; other site 1052588009205 active site 1052588009206 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1052588009207 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1052588009208 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1052588009209 Predicted membrane protein [Function unknown]; Region: COG1511 1052588009210 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 1052588009211 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1052588009212 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052588009213 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052588009214 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052588009215 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1052588009216 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1052588009217 Uncharacterized small protein [Function unknown]; Region: COG5417 1052588009218 Ubiquitin homologues; Region: UBQ; smart00213 1052588009219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1052588009220 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052588009221 CodY GAF-like domain; Region: CodY; pfam06018 1052588009222 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1052588009223 alanine dehydrogenase; Region: alaDH; TIGR00518 1052588009224 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1052588009225 hexamer interface [polypeptide binding]; other site 1052588009226 ligand binding site [chemical binding]; other site 1052588009227 putative active site [active] 1052588009228 NAD(P) binding site [chemical binding]; other site 1052588009229 Uncharacterized conserved protein [Function unknown]; Region: COG5634 1052588009230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1052588009231 Condensation domain; Region: Condensation; pfam00668 1052588009232 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1052588009233 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1052588009234 acyl-activating enzyme (AAE) consensus motif; other site 1052588009235 AMP binding site [chemical binding]; other site 1052588009236 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588009237 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1052588009238 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588009239 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052588009240 acyl-activating enzyme (AAE) consensus motif; other site 1052588009241 AMP binding site [chemical binding]; other site 1052588009242 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052588009243 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1052588009244 hydrophobic substrate binding pocket; other site 1052588009245 Isochorismatase family; Region: Isochorismatase; pfam00857 1052588009246 active site 1052588009247 conserved cis-peptide bond; other site 1052588009248 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1052588009249 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 1052588009250 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1052588009251 acyl-activating enzyme (AAE) consensus motif; other site 1052588009252 active site 1052588009253 AMP binding site [chemical binding]; other site 1052588009254 substrate binding site [chemical binding]; other site 1052588009255 isochorismate synthase DhbC; Validated; Region: PRK06923 1052588009256 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1052588009257 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1052588009258 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1052588009259 putative NAD(P) binding site [chemical binding]; other site 1052588009260 active site 1052588009261 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1052588009262 Putative esterase; Region: Esterase; pfam00756 1052588009263 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1052588009264 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1052588009265 Moco binding site; other site 1052588009266 metal coordination site [ion binding]; other site 1052588009267 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1052588009268 Predicted permease [General function prediction only]; Region: COG2056 1052588009269 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1052588009270 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1052588009271 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1052588009272 interface (dimer of trimers) [polypeptide binding]; other site 1052588009273 Substrate-binding/catalytic site; other site 1052588009274 Zn-binding sites [ion binding]; other site 1052588009275 Divergent PAP2 family; Region: DUF212; pfam02681 1052588009276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1052588009277 Putative membrane protein; Region: YuiB; pfam14068 1052588009278 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 1052588009279 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052588009280 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588009281 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1052588009282 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052588009283 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588009284 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1052588009285 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1052588009286 active site 1052588009287 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1052588009288 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1052588009289 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052588009290 Walker A/P-loop; other site 1052588009291 ATP binding site [chemical binding]; other site 1052588009292 Q-loop/lid; other site 1052588009293 ABC transporter signature motif; other site 1052588009294 Walker B; other site 1052588009295 D-loop; other site 1052588009296 H-loop/switch region; other site 1052588009297 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 1052588009298 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052588009299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588009300 Coenzyme A binding pocket [chemical binding]; other site 1052588009301 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1052588009302 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1052588009303 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1052588009304 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1052588009305 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1052588009306 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1052588009307 Nucleoside recognition; Region: Gate; pfam07670 1052588009308 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1052588009309 hypothetical protein; Provisional; Region: PRK13669 1052588009310 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052588009311 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588009312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1052588009313 NifU-like domain; Region: NifU; pfam01106 1052588009314 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1052588009315 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1052588009316 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1052588009317 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052588009318 homoserine kinase; Region: thrB; TIGR00191 1052588009319 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1052588009320 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052588009321 threonine synthase; Reviewed; Region: PRK06721 1052588009322 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1052588009323 homodimer interface [polypeptide binding]; other site 1052588009324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588009325 catalytic residue [active] 1052588009326 homoserine dehydrogenase; Provisional; Region: PRK06349 1052588009327 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1052588009328 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1052588009329 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1052588009330 spore coat protein YutH; Region: spore_yutH; TIGR02905 1052588009331 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1052588009332 tetramer interfaces [polypeptide binding]; other site 1052588009333 binuclear metal-binding site [ion binding]; other site 1052588009334 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1052588009335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588009336 active site 1052588009337 motif I; other site 1052588009338 motif II; other site 1052588009339 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588009340 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1052588009341 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1052588009342 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052588009343 lipoyl synthase; Provisional; Region: PRK05481 1052588009344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588009345 FeS/SAM binding site; other site 1052588009346 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1052588009347 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052588009348 sporulation protein YunB; Region: spo_yunB; TIGR02832 1052588009349 Uncharacterized conserved protein [Function unknown]; Region: COG3377 1052588009350 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1052588009351 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1052588009352 active site 1052588009353 metal binding site [ion binding]; metal-binding site 1052588009354 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052588009355 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1052588009356 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1052588009357 allantoinase; Provisional; Region: PRK06189 1052588009358 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1052588009359 active site 1052588009360 DRTGG domain; Region: DRTGG; pfam07085 1052588009361 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052588009362 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1052588009363 xanthine permease; Region: pbuX; TIGR03173 1052588009364 xanthine permease; Region: pbuX; TIGR03173 1052588009365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1052588009366 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 1052588009367 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1052588009368 active site 1052588009369 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1052588009370 active site 1052588009371 homotetramer interface [polypeptide binding]; other site 1052588009372 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 1052588009373 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1052588009374 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1052588009375 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1052588009376 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1052588009377 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1052588009378 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 1052588009379 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1052588009380 Ligand binding site; other site 1052588009381 metal-binding site 1052588009382 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1052588009383 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1052588009384 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1052588009385 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1052588009386 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588009387 catalytic residue [active] 1052588009388 allantoate amidohydrolase; Reviewed; Region: PRK09290 1052588009389 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1052588009390 active site 1052588009391 metal binding site [ion binding]; metal-binding site 1052588009392 dimer interface [polypeptide binding]; other site 1052588009393 Endonuclease I; Region: Endonuclease_1; cl01003 1052588009394 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1052588009395 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1052588009396 Walker A/P-loop; other site 1052588009397 ATP binding site [chemical binding]; other site 1052588009398 Q-loop/lid; other site 1052588009399 ABC transporter signature motif; other site 1052588009400 Walker B; other site 1052588009401 D-loop; other site 1052588009402 H-loop/switch region; other site 1052588009403 TOBE domain; Region: TOBE_2; pfam08402 1052588009404 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1052588009405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588009406 DNA-binding site [nucleotide binding]; DNA binding site 1052588009407 UTRA domain; Region: UTRA; pfam07702 1052588009408 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052588009409 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1052588009410 substrate binding site [chemical binding]; other site 1052588009411 ATP binding site [chemical binding]; other site 1052588009412 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052588009413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009414 dimer interface [polypeptide binding]; other site 1052588009415 conserved gate region; other site 1052588009416 putative PBP binding loops; other site 1052588009417 ABC-ATPase subunit interface; other site 1052588009418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009419 dimer interface [polypeptide binding]; other site 1052588009420 conserved gate region; other site 1052588009421 putative PBP binding loops; other site 1052588009422 ABC-ATPase subunit interface; other site 1052588009423 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052588009424 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052588009425 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1052588009426 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1052588009427 putative active site [active] 1052588009428 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1052588009429 dimer interface [polypeptide binding]; other site 1052588009430 active site 1052588009431 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 1052588009432 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1052588009433 GIY-YIG motif/motif A; other site 1052588009434 active site 1052588009435 catalytic site [active] 1052588009436 putative DNA binding site [nucleotide binding]; other site 1052588009437 metal binding site [ion binding]; metal-binding site 1052588009438 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1052588009439 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1052588009440 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588009441 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1052588009442 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1052588009443 FeS assembly protein SufB; Region: sufB; TIGR01980 1052588009444 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1052588009445 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1052588009446 trimerization site [polypeptide binding]; other site 1052588009447 active site 1052588009448 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1052588009449 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1052588009450 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588009451 catalytic residue [active] 1052588009452 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1052588009453 FeS assembly protein SufD; Region: sufD; TIGR01981 1052588009454 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1052588009455 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1052588009456 Walker A/P-loop; other site 1052588009457 ATP binding site [chemical binding]; other site 1052588009458 Q-loop/lid; other site 1052588009459 ABC transporter signature motif; other site 1052588009460 Walker B; other site 1052588009461 D-loop; other site 1052588009462 H-loop/switch region; other site 1052588009463 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1052588009464 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1052588009465 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1052588009466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009467 conserved gate region; other site 1052588009468 ABC-ATPase subunit interface; other site 1052588009469 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1052588009470 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1052588009471 Walker A/P-loop; other site 1052588009472 ATP binding site [chemical binding]; other site 1052588009473 Q-loop/lid; other site 1052588009474 ABC transporter signature motif; other site 1052588009475 Walker B; other site 1052588009476 D-loop; other site 1052588009477 H-loop/switch region; other site 1052588009478 NIL domain; Region: NIL; pfam09383 1052588009479 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1052588009480 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052588009481 catalytic residues [active] 1052588009482 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1052588009483 putative active site [active] 1052588009484 putative metal binding site [ion binding]; other site 1052588009485 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1052588009486 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1052588009487 lipoyl attachment site [posttranslational modification]; other site 1052588009488 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1052588009489 ArsC family; Region: ArsC; pfam03960 1052588009490 putative ArsC-like catalytic residues; other site 1052588009491 putative TRX-like catalytic residues [active] 1052588009492 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1052588009493 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052588009494 active site 1052588009495 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1052588009496 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1052588009497 dimer interface [polypeptide binding]; other site 1052588009498 active site 1052588009499 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1052588009500 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1052588009501 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1052588009502 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1052588009503 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1052588009504 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588009505 substrate binding site [chemical binding]; other site 1052588009506 oxyanion hole (OAH) forming residues; other site 1052588009507 trimer interface [polypeptide binding]; other site 1052588009508 Proline dehydrogenase; Region: Pro_dh; pfam01619 1052588009509 Coat F domain; Region: Coat_F; pfam07875 1052588009510 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588009511 MarR family; Region: MarR; pfam01047 1052588009512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588009513 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588009514 putative substrate translocation pore; other site 1052588009515 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1052588009516 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1052588009517 classical (c) SDRs; Region: SDR_c; cd05233 1052588009518 NAD(P) binding site [chemical binding]; other site 1052588009519 active site 1052588009520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588009521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588009522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052588009523 dimerization interface [polypeptide binding]; other site 1052588009524 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1052588009525 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052588009526 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052588009527 Walker A/P-loop; other site 1052588009528 ATP binding site [chemical binding]; other site 1052588009529 Q-loop/lid; other site 1052588009530 ABC transporter signature motif; other site 1052588009531 Walker B; other site 1052588009532 D-loop; other site 1052588009533 H-loop/switch region; other site 1052588009534 YusW-like protein; Region: YusW; pfam14039 1052588009535 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1052588009536 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1052588009537 active site 1052588009538 Zn binding site [ion binding]; other site 1052588009539 short chain dehydrogenase; Provisional; Region: PRK06914 1052588009540 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1052588009541 NADP binding site [chemical binding]; other site 1052588009542 active site 1052588009543 steroid binding site; other site 1052588009544 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1052588009545 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1052588009546 dimerization interface [polypeptide binding]; other site 1052588009547 DPS ferroxidase diiron center [ion binding]; other site 1052588009548 ion pore; other site 1052588009549 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1052588009550 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1052588009551 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052588009552 protein binding site [polypeptide binding]; other site 1052588009553 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588009554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588009555 active site 1052588009556 phosphorylation site [posttranslational modification] 1052588009557 intermolecular recognition site; other site 1052588009558 dimerization interface [polypeptide binding]; other site 1052588009559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588009560 DNA binding site [nucleotide binding] 1052588009561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052588009562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588009563 dimerization interface [polypeptide binding]; other site 1052588009564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588009565 dimer interface [polypeptide binding]; other site 1052588009566 phosphorylation site [posttranslational modification] 1052588009567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588009568 ATP binding site [chemical binding]; other site 1052588009569 Mg2+ binding site [ion binding]; other site 1052588009570 G-X-G motif; other site 1052588009571 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588009572 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588009573 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1052588009574 Class II fumarases; Region: Fumarase_classII; cd01362 1052588009575 active site 1052588009576 tetramer interface [polypeptide binding]; other site 1052588009577 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1052588009578 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052588009579 Spore germination protein; Region: Spore_permease; pfam03845 1052588009580 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052588009581 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052588009582 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588009583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588009584 active site 1052588009585 phosphorylation site [posttranslational modification] 1052588009586 intermolecular recognition site; other site 1052588009587 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588009588 DNA binding residues [nucleotide binding] 1052588009589 dimerization interface [polypeptide binding]; other site 1052588009590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588009591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588009592 dimerization interface [polypeptide binding]; other site 1052588009593 Histidine kinase; Region: HisKA_3; pfam07730 1052588009594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588009595 ATP binding site [chemical binding]; other site 1052588009596 Mg2+ binding site [ion binding]; other site 1052588009597 G-X-G motif; other site 1052588009598 Predicted membrane protein [Function unknown]; Region: COG4758 1052588009599 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1052588009600 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1052588009601 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1052588009602 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052588009603 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052588009604 PspA/IM30 family; Region: PspA_IM30; pfam04012 1052588009605 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052588009606 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 1052588009607 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052588009608 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052588009609 Walker A/P-loop; other site 1052588009610 ATP binding site [chemical binding]; other site 1052588009611 Q-loop/lid; other site 1052588009612 ABC transporter signature motif; other site 1052588009613 Walker B; other site 1052588009614 D-loop; other site 1052588009615 H-loop/switch region; other site 1052588009616 Adenosylcobinamide amidohydrolase [Coenzyme metabolism]; Region: cbiZ; COG1865 1052588009617 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052588009618 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588009619 ABC-ATPase subunit interface; other site 1052588009620 dimer interface [polypeptide binding]; other site 1052588009621 putative PBP binding regions; other site 1052588009622 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052588009623 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1052588009624 putative binding site residues; other site 1052588009625 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1052588009626 classical (c) SDRs; Region: SDR_c; cd05233 1052588009627 NAD(P) binding site [chemical binding]; other site 1052588009628 active site 1052588009629 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1052588009630 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052588009631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588009632 dimer interface [polypeptide binding]; other site 1052588009633 phosphorylation site [posttranslational modification] 1052588009634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588009635 ATP binding site [chemical binding]; other site 1052588009636 Mg2+ binding site [ion binding]; other site 1052588009637 G-X-G motif; other site 1052588009638 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588009639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588009640 active site 1052588009641 phosphorylation site [posttranslational modification] 1052588009642 intermolecular recognition site; other site 1052588009643 dimerization interface [polypeptide binding]; other site 1052588009644 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588009645 DNA binding site [nucleotide binding] 1052588009646 hypothetical protein; Provisional; Region: PRK14082 1052588009647 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1052588009648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588009649 DNA binding residues [nucleotide binding] 1052588009650 YvrJ protein family; Region: YvrJ; pfam12841 1052588009651 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1052588009652 Cupin; Region: Cupin_1; smart00835 1052588009653 Cupin; Region: Cupin_1; smart00835 1052588009654 Regulatory protein YrvL; Region: YrvL; pfam14184 1052588009655 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052588009656 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052588009657 FtsX-like permease family; Region: FtsX; pfam02687 1052588009658 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588009659 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052588009660 Walker A/P-loop; other site 1052588009661 ATP binding site [chemical binding]; other site 1052588009662 Q-loop/lid; other site 1052588009663 ABC transporter signature motif; other site 1052588009664 Walker B; other site 1052588009665 D-loop; other site 1052588009666 H-loop/switch region; other site 1052588009667 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1052588009668 DNA damage checkpoint protein; Region: LCD1; pfam09798 1052588009669 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052588009670 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052588009671 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052588009672 Walker A/P-loop; other site 1052588009673 ATP binding site [chemical binding]; other site 1052588009674 Q-loop/lid; other site 1052588009675 ABC transporter signature motif; other site 1052588009676 Walker B; other site 1052588009677 D-loop; other site 1052588009678 H-loop/switch region; other site 1052588009679 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052588009680 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588009681 ABC-ATPase subunit interface; other site 1052588009682 dimer interface [polypeptide binding]; other site 1052588009683 putative PBP binding regions; other site 1052588009684 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052588009685 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588009686 ABC-ATPase subunit interface; other site 1052588009687 dimer interface [polypeptide binding]; other site 1052588009688 putative PBP binding regions; other site 1052588009689 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052588009690 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052588009691 putative ligand binding residues [chemical binding]; other site 1052588009692 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1052588009693 small, acid-soluble spore protein, SspJ family; Region: spore_sspJ; TIGR02863 1052588009694 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1052588009695 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052588009696 Sulfatase; Region: Sulfatase; pfam00884 1052588009697 DNA binding domain, excisionase family; Region: excise; TIGR01764 1052588009698 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 1052588009699 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1052588009700 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1052588009701 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1052588009702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009703 dimer interface [polypeptide binding]; other site 1052588009704 conserved gate region; other site 1052588009705 putative PBP binding loops; other site 1052588009706 ABC-ATPase subunit interface; other site 1052588009707 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052588009708 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588009709 active site 1052588009710 catalytic tetrad [active] 1052588009711 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1052588009712 sulfite reductase subunit beta; Provisional; Region: PRK13504 1052588009713 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052588009714 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052588009715 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1052588009716 Flavodoxin; Region: Flavodoxin_1; pfam00258 1052588009717 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1052588009718 FAD binding pocket [chemical binding]; other site 1052588009719 FAD binding motif [chemical binding]; other site 1052588009720 catalytic residues [active] 1052588009721 NAD binding pocket [chemical binding]; other site 1052588009722 phosphate binding motif [ion binding]; other site 1052588009723 beta-alpha-beta structure motif; other site 1052588009724 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1052588009725 Part of AAA domain; Region: AAA_19; pfam13245 1052588009726 Family description; Region: UvrD_C_2; pfam13538 1052588009727 Predicted membrane protein [Function unknown]; Region: COG2860 1052588009728 UPF0126 domain; Region: UPF0126; pfam03458 1052588009729 UPF0126 domain; Region: UPF0126; pfam03458 1052588009730 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1052588009731 Thioredoxin; Region: Thioredoxin_4; pfam13462 1052588009732 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1052588009733 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052588009734 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052588009735 metal-binding site [ion binding] 1052588009736 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052588009737 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1052588009738 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052588009739 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052588009740 metal-binding site [ion binding] 1052588009741 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052588009742 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052588009743 metal-binding site [ion binding] 1052588009744 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052588009745 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1052588009746 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052588009747 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052588009748 metal-binding site [ion binding] 1052588009749 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 1052588009750 putative homodimer interface [polypeptide binding]; other site 1052588009751 putative homotetramer interface [polypeptide binding]; other site 1052588009752 allosteric switch controlling residues; other site 1052588009753 putative metal binding site [ion binding]; other site 1052588009754 putative homodimer-homodimer interface [polypeptide binding]; other site 1052588009755 putative oxidoreductase; Provisional; Region: PRK11579 1052588009756 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052588009757 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052588009758 azoreductase; Reviewed; Region: PRK00170 1052588009759 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052588009760 Predicted membrane protein [Function unknown]; Region: COG1289 1052588009761 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1052588009762 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1052588009763 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052588009764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588009765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588009766 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052588009767 classical (c) SDRs; Region: SDR_c; cd05233 1052588009768 NAD(P) binding site [chemical binding]; other site 1052588009769 active site 1052588009770 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1052588009771 SmpB-tmRNA interface; other site 1052588009772 ribonuclease R; Region: RNase_R; TIGR02063 1052588009773 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1052588009774 Cold shock protein domain; Region: CSP; smart00357 1052588009775 RNB domain; Region: RNB; pfam00773 1052588009776 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1052588009777 RNA binding site [nucleotide binding]; other site 1052588009778 Esterase/lipase [General function prediction only]; Region: COG1647 1052588009779 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052588009780 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052588009781 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588009782 sequence-specific DNA binding site [nucleotide binding]; other site 1052588009783 salt bridge; other site 1052588009784 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052588009785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588009786 non-specific DNA binding site [nucleotide binding]; other site 1052588009787 salt bridge; other site 1052588009788 sequence-specific DNA binding site [nucleotide binding]; other site 1052588009789 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052588009790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588009791 non-specific DNA binding site [nucleotide binding]; other site 1052588009792 salt bridge; other site 1052588009793 sequence-specific DNA binding site [nucleotide binding]; other site 1052588009794 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052588009795 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052588009796 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1052588009797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588009798 dimerization interface [polypeptide binding]; other site 1052588009799 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052588009800 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588009801 dimer interface [polypeptide binding]; other site 1052588009802 putative CheW interface [polypeptide binding]; other site 1052588009803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009804 dimer interface [polypeptide binding]; other site 1052588009805 conserved gate region; other site 1052588009806 putative PBP binding loops; other site 1052588009807 ABC-ATPase subunit interface; other site 1052588009808 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1052588009809 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1052588009810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009811 dimer interface [polypeptide binding]; other site 1052588009812 conserved gate region; other site 1052588009813 putative PBP binding loops; other site 1052588009814 ABC-ATPase subunit interface; other site 1052588009815 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1052588009816 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1052588009817 Walker A/P-loop; other site 1052588009818 ATP binding site [chemical binding]; other site 1052588009819 Q-loop/lid; other site 1052588009820 ABC transporter signature motif; other site 1052588009821 Walker B; other site 1052588009822 D-loop; other site 1052588009823 H-loop/switch region; other site 1052588009824 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1052588009825 Predicted transcriptional regulators [Transcription]; Region: COG1510 1052588009826 MarR family; Region: MarR_2; pfam12802 1052588009827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009828 dimer interface [polypeptide binding]; other site 1052588009829 conserved gate region; other site 1052588009830 putative PBP binding loops; other site 1052588009831 ABC-ATPase subunit interface; other site 1052588009832 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1052588009833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009834 dimer interface [polypeptide binding]; other site 1052588009835 conserved gate region; other site 1052588009836 putative PBP binding loops; other site 1052588009837 ABC-ATPase subunit interface; other site 1052588009838 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1052588009839 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1052588009840 Walker A/P-loop; other site 1052588009841 ATP binding site [chemical binding]; other site 1052588009842 Q-loop/lid; other site 1052588009843 ABC transporter signature motif; other site 1052588009844 Walker B; other site 1052588009845 D-loop; other site 1052588009846 H-loop/switch region; other site 1052588009847 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1052588009848 Predicted transcriptional regulators [Transcription]; Region: COG1510 1052588009849 MarR family; Region: MarR_2; pfam12802 1052588009850 membrane protein, MarC family; Region: TIGR00427 1052588009851 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1052588009852 pentamer interface [polypeptide binding]; other site 1052588009853 dodecaamer interface [polypeptide binding]; other site 1052588009854 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1052588009855 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1052588009856 Double zinc ribbon; Region: DZR; pfam12773 1052588009857 Predicted membrane protein [Function unknown]; Region: COG4640 1052588009858 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1052588009859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588009860 Coenzyme A binding pocket [chemical binding]; other site 1052588009861 enolase; Provisional; Region: eno; PRK00077 1052588009862 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1052588009863 dimer interface [polypeptide binding]; other site 1052588009864 metal binding site [ion binding]; metal-binding site 1052588009865 substrate binding pocket [chemical binding]; other site 1052588009866 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1052588009867 phosphoglyceromutase; Provisional; Region: PRK05434 1052588009868 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1052588009869 triosephosphate isomerase; Provisional; Region: PRK14565 1052588009870 substrate binding site [chemical binding]; other site 1052588009871 dimer interface [polypeptide binding]; other site 1052588009872 catalytic triad [active] 1052588009873 Phosphoglycerate kinase; Region: PGK; pfam00162 1052588009874 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1052588009875 substrate binding site [chemical binding]; other site 1052588009876 hinge regions; other site 1052588009877 ADP binding site [chemical binding]; other site 1052588009878 catalytic site [active] 1052588009879 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1052588009880 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1052588009881 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1052588009882 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1052588009883 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1052588009884 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1052588009885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588009886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588009887 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588009888 DNA-binding site [nucleotide binding]; DNA binding site 1052588009889 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588009890 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1052588009891 putative dimerization interface [polypeptide binding]; other site 1052588009892 putative ligand binding site [chemical binding]; other site 1052588009893 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1052588009894 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052588009895 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1052588009896 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588009897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588009898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588009899 dimerization interface [polypeptide binding]; other site 1052588009900 EamA-like transporter family; Region: EamA; pfam00892 1052588009901 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052588009902 EamA-like transporter family; Region: EamA; pfam00892 1052588009903 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052588009904 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1052588009905 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1052588009906 active site 1052588009907 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1052588009908 iron-sulfur cluster-binding protein; Region: TIGR00273 1052588009909 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1052588009910 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1052588009911 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1052588009912 Cysteine-rich domain; Region: CCG; pfam02754 1052588009913 Cysteine-rich domain; Region: CCG; pfam02754 1052588009914 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588009915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588009916 active site 1052588009917 phosphorylation site [posttranslational modification] 1052588009918 intermolecular recognition site; other site 1052588009919 dimerization interface [polypeptide binding]; other site 1052588009920 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588009921 DNA binding residues [nucleotide binding] 1052588009922 dimerization interface [polypeptide binding]; other site 1052588009923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588009924 Histidine kinase; Region: HisKA_3; pfam07730 1052588009925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588009926 ATP binding site [chemical binding]; other site 1052588009927 Mg2+ binding site [ion binding]; other site 1052588009928 G-X-G motif; other site 1052588009929 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1052588009930 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1052588009931 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052588009932 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052588009933 Walker A/P-loop; other site 1052588009934 ATP binding site [chemical binding]; other site 1052588009935 Q-loop/lid; other site 1052588009936 ABC transporter signature motif; other site 1052588009937 Walker B; other site 1052588009938 D-loop; other site 1052588009939 H-loop/switch region; other site 1052588009940 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052588009941 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1052588009942 catalytic site [active] 1052588009943 PAS domain S-box; Region: sensory_box; TIGR00229 1052588009944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588009945 putative active site [active] 1052588009946 heme pocket [chemical binding]; other site 1052588009947 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1052588009948 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1052588009949 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 1052588009950 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1052588009951 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1052588009952 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1052588009953 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1052588009954 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052588009955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009956 dimer interface [polypeptide binding]; other site 1052588009957 conserved gate region; other site 1052588009958 putative PBP binding loops; other site 1052588009959 ABC-ATPase subunit interface; other site 1052588009960 TM2 domain; Region: TM2; pfam05154 1052588009961 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052588009962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009963 dimer interface [polypeptide binding]; other site 1052588009964 conserved gate region; other site 1052588009965 ABC-ATPase subunit interface; other site 1052588009966 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1052588009967 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052588009968 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588009969 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588009970 DNA binding site [nucleotide binding] 1052588009971 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1052588009972 putative dimerization interface [polypeptide binding]; other site 1052588009973 putative ligand binding site [chemical binding]; other site 1052588009974 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1052588009975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588009976 DNA-binding site [nucleotide binding]; DNA binding site 1052588009977 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1052588009978 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1052588009979 L-lactate permease; Region: Lactate_perm; pfam02652 1052588009980 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1052588009981 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1052588009982 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1052588009983 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1052588009984 YvfG protein; Region: YvfG; pfam09628 1052588009985 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1052588009986 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1052588009987 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1052588009988 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1052588009989 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1052588009990 inhibitor-cofactor binding pocket; inhibition site 1052588009991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588009992 catalytic residue [active] 1052588009993 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1052588009994 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1052588009995 putative trimer interface [polypeptide binding]; other site 1052588009996 putative CoA binding site [chemical binding]; other site 1052588009997 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1052588009998 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1052588009999 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052588010000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588010001 active site 1052588010002 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1052588010003 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1052588010004 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588010005 active site 1052588010006 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588010007 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1052588010008 putative ADP-binding pocket [chemical binding]; other site 1052588010009 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052588010010 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1052588010011 active site 1052588010012 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1052588010013 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588010014 putative ADP-binding pocket [chemical binding]; other site 1052588010015 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1052588010016 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1052588010017 NAD(P) binding site [chemical binding]; other site 1052588010018 homodimer interface [polypeptide binding]; other site 1052588010019 substrate binding site [chemical binding]; other site 1052588010020 active site 1052588010021 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1052588010022 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1052588010023 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1052588010024 Chain length determinant protein; Region: Wzz; cl15801 1052588010025 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052588010026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588010027 non-specific DNA binding site [nucleotide binding]; other site 1052588010028 salt bridge; other site 1052588010029 sequence-specific DNA binding site [nucleotide binding]; other site 1052588010030 Anti-repressor SinI; Region: SinI; pfam08671 1052588010031 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1052588010032 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1052588010033 substrate binding pocket [chemical binding]; other site 1052588010034 catalytic triad [active] 1052588010035 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1052588010036 hypothetical protein; Provisional; Region: PRK00872 1052588010037 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1052588010038 aspartate racemase; Region: asp_race; TIGR00035 1052588010039 Beta-lactamase; Region: Beta-lactamase; pfam00144 1052588010040 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052588010041 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1052588010042 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1052588010043 active site 1052588010044 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1052588010045 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052588010046 substrate binding [chemical binding]; other site 1052588010047 active site 1052588010048 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052588010049 amino acid transporter; Region: 2A0306; TIGR00909 1052588010050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588010051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588010052 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052588010053 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052588010054 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1052588010055 Clp protease; Region: CLP_protease; pfam00574 1052588010056 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1052588010057 oligomer interface [polypeptide binding]; other site 1052588010058 active site residues [active] 1052588010059 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1052588010060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588010061 motif II; other site 1052588010062 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052588010063 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052588010064 Ca binding site [ion binding]; other site 1052588010065 active site 1052588010066 catalytic site [active] 1052588010067 maltose phosphorylase; Provisional; Region: PRK13807 1052588010068 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1052588010069 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1052588010070 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1052588010071 Predicted integral membrane protein [Function unknown]; Region: COG5521 1052588010072 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052588010073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588010074 dimer interface [polypeptide binding]; other site 1052588010075 conserved gate region; other site 1052588010076 ABC-ATPase subunit interface; other site 1052588010077 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1052588010078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588010079 dimer interface [polypeptide binding]; other site 1052588010080 conserved gate region; other site 1052588010081 putative PBP binding loops; other site 1052588010082 ABC-ATPase subunit interface; other site 1052588010083 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1052588010084 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052588010085 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1052588010086 homodimer interface [polypeptide binding]; other site 1052588010087 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1052588010088 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1052588010089 active site 1052588010090 homodimer interface [polypeptide binding]; other site 1052588010091 catalytic site [active] 1052588010092 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588010093 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588010094 DNA binding site [nucleotide binding] 1052588010095 domain linker motif; other site 1052588010096 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052588010097 ligand binding site [chemical binding]; other site 1052588010098 dimerization interface [polypeptide binding]; other site 1052588010099 TIGR00730 family protein; Region: TIGR00730 1052588010100 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1052588010101 metal binding site [ion binding]; metal-binding site 1052588010102 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1052588010103 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1052588010104 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1052588010105 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1052588010106 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1052588010107 active site clefts [active] 1052588010108 zinc binding site [ion binding]; other site 1052588010109 dimer interface [polypeptide binding]; other site 1052588010110 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1052588010111 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1052588010112 dimerization interface [polypeptide binding]; other site 1052588010113 ligand binding site [chemical binding]; other site 1052588010114 NADP binding site [chemical binding]; other site 1052588010115 catalytic site [active] 1052588010116 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588010117 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052588010118 Walker A/P-loop; other site 1052588010119 ATP binding site [chemical binding]; other site 1052588010120 Q-loop/lid; other site 1052588010121 ABC transporter signature motif; other site 1052588010122 Walker B; other site 1052588010123 D-loop; other site 1052588010124 H-loop/switch region; other site 1052588010125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052588010126 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1052588010127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588010128 ATP binding site [chemical binding]; other site 1052588010129 Mg2+ binding site [ion binding]; other site 1052588010130 G-X-G motif; other site 1052588010131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588010132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588010133 active site 1052588010134 phosphorylation site [posttranslational modification] 1052588010135 intermolecular recognition site; other site 1052588010136 dimerization interface [polypeptide binding]; other site 1052588010137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588010138 DNA binding site [nucleotide binding] 1052588010139 Lysis protein; Region: Lysis_col; pfam02402 1052588010140 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1052588010141 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052588010142 dimerization domain swap beta strand [polypeptide binding]; other site 1052588010143 regulatory protein interface [polypeptide binding]; other site 1052588010144 active site 1052588010145 regulatory phosphorylation site [posttranslational modification]; other site 1052588010146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1052588010147 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1052588010148 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1052588010149 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1052588010150 phosphate binding site [ion binding]; other site 1052588010151 putative substrate binding pocket [chemical binding]; other site 1052588010152 dimer interface [polypeptide binding]; other site 1052588010153 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1052588010154 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1052588010155 putative active site [active] 1052588010156 nucleotide binding site [chemical binding]; other site 1052588010157 nudix motif; other site 1052588010158 putative metal binding site [ion binding]; other site 1052588010159 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1052588010160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052588010161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588010162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1052588010163 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052588010164 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052588010165 Integrase core domain; Region: rve; pfam00665 1052588010166 HTH-like domain; Region: HTH_21; pfam13276 1052588010167 Homeodomain-like domain; Region: HTH_23; cl17451 1052588010168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588010169 binding surface 1052588010170 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052588010171 TPR motif; other site 1052588010172 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052588010173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588010174 TPR motif; other site 1052588010175 binding surface 1052588010176 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588010177 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052588010178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588010179 Walker A/P-loop; other site 1052588010180 ATP binding site [chemical binding]; other site 1052588010181 Q-loop/lid; other site 1052588010182 ABC transporter signature motif; other site 1052588010183 Walker B; other site 1052588010184 D-loop; other site 1052588010185 H-loop/switch region; other site 1052588010186 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1052588010187 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1052588010188 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1052588010189 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1052588010190 metal binding site [ion binding]; metal-binding site 1052588010191 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1052588010192 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1052588010193 substrate binding site [chemical binding]; other site 1052588010194 glutamase interaction surface [polypeptide binding]; other site 1052588010195 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1052588010196 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1052588010197 catalytic residues [active] 1052588010198 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1052588010199 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1052588010200 putative active site [active] 1052588010201 oxyanion strand; other site 1052588010202 catalytic triad [active] 1052588010203 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1052588010204 putative active site pocket [active] 1052588010205 4-fold oligomerization interface [polypeptide binding]; other site 1052588010206 metal binding residues [ion binding]; metal-binding site 1052588010207 3-fold/trimer interface [polypeptide binding]; other site 1052588010208 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1052588010209 histidinol dehydrogenase; Region: hisD; TIGR00069 1052588010210 NAD binding site [chemical binding]; other site 1052588010211 dimerization interface [polypeptide binding]; other site 1052588010212 product binding site; other site 1052588010213 substrate binding site [chemical binding]; other site 1052588010214 zinc binding site [ion binding]; other site 1052588010215 catalytic residues [active] 1052588010216 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1052588010217 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1052588010218 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1052588010219 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1052588010220 dimer interface [polypeptide binding]; other site 1052588010221 motif 1; other site 1052588010222 active site 1052588010223 motif 2; other site 1052588010224 motif 3; other site 1052588010225 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1052588010226 putative active site [active] 1052588010227 Pectate lyase; Region: Pectate_lyase; pfam03211 1052588010228 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1052588010229 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1052588010230 CoA binding site [chemical binding]; other site 1052588010231 active site 1052588010232 pyrophosphatase PpaX; Provisional; Region: PRK13288 1052588010233 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1052588010234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588010235 motif II; other site 1052588010236 Nucleoside recognition; Region: Gate; pfam07670 1052588010237 Nucleoside recognition; Region: Gate; pfam07670 1052588010238 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1052588010239 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1052588010240 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1052588010241 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1052588010242 Hpr binding site; other site 1052588010243 active site 1052588010244 homohexamer subunit interaction site [polypeptide binding]; other site 1052588010245 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1052588010246 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1052588010247 active site 1052588010248 dimer interface [polypeptide binding]; other site 1052588010249 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1052588010250 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1052588010251 active site 1052588010252 trimer interface [polypeptide binding]; other site 1052588010253 allosteric site; other site 1052588010254 active site lid [active] 1052588010255 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052588010256 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052588010257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588010258 DNA-binding site [nucleotide binding]; DNA binding site 1052588010259 UTRA domain; Region: UTRA; pfam07702 1052588010260 Lamin Tail Domain; Region: LTD; pfam00932 1052588010261 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1052588010262 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052588010263 putative active site [active] 1052588010264 putative metal binding site [ion binding]; other site 1052588010265 Predicted membrane protein [Function unknown]; Region: COG1950 1052588010266 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1052588010267 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1052588010268 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052588010269 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1052588010270 flagellin; Provisional; Region: PRK12804 1052588010271 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052588010272 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1052588010273 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1052588010274 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1052588010275 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1052588010276 excinuclease ABC subunit B; Provisional; Region: PRK05298 1052588010277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588010278 ATP binding site [chemical binding]; other site 1052588010279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588010280 nucleotide binding region [chemical binding]; other site 1052588010281 ATP-binding site [chemical binding]; other site 1052588010282 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1052588010283 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1052588010284 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1052588010285 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 1052588010286 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1052588010287 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588010288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588010289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010290 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588010291 putative substrate translocation pore; other site 1052588010292 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1052588010293 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052588010294 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1052588010295 C-terminal peptidase (prc); Region: prc; TIGR00225 1052588010296 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1052588010297 protein binding site [polypeptide binding]; other site 1052588010298 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1052588010299 Catalytic dyad [active] 1052588010300 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052588010301 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1052588010302 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1052588010303 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1052588010304 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 1052588010305 Walker A/P-loop; other site 1052588010306 ATP binding site [chemical binding]; other site 1052588010307 Q-loop/lid; other site 1052588010308 ABC transporter signature motif; other site 1052588010309 Walker B; other site 1052588010310 D-loop; other site 1052588010311 H-loop/switch region; other site 1052588010312 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1052588010313 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1052588010314 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052588010315 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588010316 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588010317 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052588010318 peptide chain release factor 2; Provisional; Region: PRK06746 1052588010319 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1052588010320 RF-1 domain; Region: RF-1; pfam00472 1052588010321 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1052588010322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1052588010323 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1052588010324 nucleotide binding region [chemical binding]; other site 1052588010325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1052588010326 ATP-binding site [chemical binding]; other site 1052588010327 SEC-C motif; Region: SEC-C; pfam02810 1052588010328 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1052588010329 30S subunit binding site; other site 1052588010330 Flagellar protein FliT; Region: FliT; pfam05400 1052588010331 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 1052588010332 flagellar capping protein; Validated; Region: fliD; PRK07737 1052588010333 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1052588010334 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1052588010335 FlaG protein; Region: FlaG; cl00591 1052588010336 flagellin; Provisional; Region: PRK12804 1052588010337 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1052588010338 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052588010339 carbon storage regulator; Provisional; Region: PRK01712 1052588010340 flagellar assembly protein FliW; Provisional; Region: PRK13285 1052588010341 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1052588010342 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1052588010343 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052588010344 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1052588010345 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1052588010346 FlgN protein; Region: FlgN; pfam05130 1052588010347 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 1052588010348 flagellar operon protein TIGR03826; Region: YvyF 1052588010349 comF family protein; Region: comF; TIGR00201 1052588010350 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588010351 active site 1052588010352 Late competence development protein ComFB; Region: ComFB; pfam10719 1052588010353 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1052588010354 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588010355 ATP binding site [chemical binding]; other site 1052588010356 putative Mg++ binding site [ion binding]; other site 1052588010357 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588010358 nucleotide binding region [chemical binding]; other site 1052588010359 ATP-binding site [chemical binding]; other site 1052588010360 EDD domain protein, DegV family; Region: DegV; TIGR00762 1052588010361 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1052588010362 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588010363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588010364 active site 1052588010365 phosphorylation site [posttranslational modification] 1052588010366 intermolecular recognition site; other site 1052588010367 dimerization interface [polypeptide binding]; other site 1052588010368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588010369 DNA binding residues [nucleotide binding] 1052588010370 dimerization interface [polypeptide binding]; other site 1052588010371 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588010372 Histidine kinase; Region: HisKA_3; pfam07730 1052588010373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588010374 ATP binding site [chemical binding]; other site 1052588010375 Mg2+ binding site [ion binding]; other site 1052588010376 G-X-G motif; other site 1052588010377 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1052588010378 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1052588010379 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1052588010380 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1052588010381 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1052588010382 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1052588010383 Mg++ binding site [ion binding]; other site 1052588010384 putative catalytic motif [active] 1052588010385 substrate binding site [chemical binding]; other site 1052588010386 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1052588010387 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588010388 putative homodimer interface [polypeptide binding]; other site 1052588010389 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052588010390 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588010391 active site 1052588010392 Chain length determinant protein; Region: Wzz; pfam02706 1052588010393 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1052588010394 O-Antigen ligase; Region: Wzy_C; pfam04932 1052588010395 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1052588010396 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1052588010397 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052588010398 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1052588010399 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588010400 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1052588010401 colanic acid exporter; Provisional; Region: PRK10459 1052588010402 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1052588010403 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1052588010404 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1052588010405 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1052588010406 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052588010407 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052588010408 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052588010409 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1052588010410 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052588010411 active site 1052588010412 metal binding site [ion binding]; metal-binding site 1052588010413 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052588010414 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1052588010415 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052588010416 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052588010417 Stage II sporulation protein; Region: SpoIID; pfam08486 1052588010418 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1052588010419 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 1052588010420 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1052588010421 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1052588010422 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1052588010423 active site 1052588010424 homodimer interface [polypeptide binding]; other site 1052588010425 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052588010426 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1052588010427 active site 1052588010428 tetramer interface; other site 1052588010429 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1052588010430 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1052588010431 Walker A/P-loop; other site 1052588010432 ATP binding site [chemical binding]; other site 1052588010433 Q-loop/lid; other site 1052588010434 ABC transporter signature motif; other site 1052588010435 Walker B; other site 1052588010436 D-loop; other site 1052588010437 H-loop/switch region; other site 1052588010438 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1052588010439 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1052588010440 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1052588010441 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052588010442 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1052588010443 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1052588010444 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588010445 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1052588010446 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1052588010447 active site 1052588010448 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1052588010449 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1052588010450 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1052588010451 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052588010452 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1052588010453 Bacterial SH3 domain; Region: SH3_3; pfam08239 1052588010454 Lysozyme subfamily 2; Region: LYZ2; smart00047 1052588010455 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1052588010456 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1052588010457 Spore germination protein; Region: Spore_permease; pfam03845 1052588010458 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052588010459 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052588010460 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052588010461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010462 putative substrate translocation pore; other site 1052588010463 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1052588010464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588010465 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052588010466 active site 1052588010467 motif I; other site 1052588010468 motif II; other site 1052588010469 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1052588010470 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052588010471 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052588010472 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052588010473 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052588010474 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052588010475 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052588010476 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1052588010477 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1052588010478 putative active site [active] 1052588010479 putative metal binding site [ion binding]; other site 1052588010480 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1052588010481 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1052588010482 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052588010483 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588010484 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588010485 DNA binding site [nucleotide binding] 1052588010486 domain linker motif; other site 1052588010487 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052588010488 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052588010489 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1052588010490 substrate binding site [chemical binding]; other site 1052588010491 dimer interface [polypeptide binding]; other site 1052588010492 ATP binding site [chemical binding]; other site 1052588010493 D-ribose pyranase; Provisional; Region: PRK11797 1052588010494 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1052588010495 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1052588010496 Walker A/P-loop; other site 1052588010497 ATP binding site [chemical binding]; other site 1052588010498 Q-loop/lid; other site 1052588010499 ABC transporter signature motif; other site 1052588010500 Walker B; other site 1052588010501 D-loop; other site 1052588010502 H-loop/switch region; other site 1052588010503 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1052588010504 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1052588010505 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1052588010506 TM-ABC transporter signature motif; other site 1052588010507 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1052588010508 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1052588010509 ligand binding site [chemical binding]; other site 1052588010510 dimerization interface [polypeptide binding]; other site 1052588010511 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1052588010512 Bacterial SH3 domain; Region: SH3_3; cl17532 1052588010513 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1052588010514 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1052588010515 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052588010516 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1052588010517 acetolactate synthase; Reviewed; Region: PRK08617 1052588010518 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052588010519 PYR/PP interface [polypeptide binding]; other site 1052588010520 dimer interface [polypeptide binding]; other site 1052588010521 TPP binding site [chemical binding]; other site 1052588010522 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1052588010523 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1052588010524 TPP-binding site [chemical binding]; other site 1052588010525 dimer interface [polypeptide binding]; other site 1052588010526 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1052588010527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588010528 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1052588010529 putative dimerization interface [polypeptide binding]; other site 1052588010530 putative substrate binding pocket [chemical binding]; other site 1052588010531 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1052588010532 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1052588010533 transmembrane helices; other site 1052588010534 CotH protein; Region: CotH; pfam08757 1052588010535 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1052588010536 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1052588010537 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1052588010538 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1052588010539 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052588010540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588010541 putative DNA binding site [nucleotide binding]; other site 1052588010542 putative Zn2+ binding site [ion binding]; other site 1052588010543 AsnC family; Region: AsnC_trans_reg; pfam01037 1052588010544 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1052588010545 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1052588010546 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1052588010547 Active_site [active] 1052588010548 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052588010549 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1052588010550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1052588010551 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1052588010552 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1052588010553 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052588010554 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1052588010555 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1052588010556 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1052588010557 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1052588010558 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1052588010559 Chain length determinant protein; Region: Wzz; cl15801 1052588010560 SWIM zinc finger; Region: SWIM; pfam04434 1052588010561 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1052588010562 SNF2 Helicase protein; Region: DUF3670; pfam12419 1052588010563 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588010564 ATP binding site [chemical binding]; other site 1052588010565 putative Mg++ binding site [ion binding]; other site 1052588010566 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588010567 nucleotide binding region [chemical binding]; other site 1052588010568 ATP-binding site [chemical binding]; other site 1052588010569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588010570 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052588010571 active site 1052588010572 motif I; other site 1052588010573 motif II; other site 1052588010574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588010575 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052588010576 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1052588010577 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1052588010578 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1052588010579 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1052588010580 dimer interface [polypeptide binding]; other site 1052588010581 ssDNA binding site [nucleotide binding]; other site 1052588010582 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588010583 YwpF-like protein; Region: YwpF; pfam14183 1052588010584 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1052588010585 active site 1052588010586 catalytic site [active] 1052588010587 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1052588010588 Collagen binding domain; Region: Collagen_bind; pfam05737 1052588010589 Collagen binding domain; Region: Collagen_bind; pfam05737 1052588010590 Collagen binding domain; Region: Collagen_bind; pfam05737 1052588010591 Collagen binding domain; Region: Collagen_bind; pfam05737 1052588010592 Cna protein B-type domain; Region: Cna_B; pfam05738 1052588010593 Cna protein B-type domain; Region: Cna_B; pfam05738 1052588010594 Cna protein B-type domain; Region: Cna_B; pfam05738 1052588010595 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1052588010596 Cna protein B-type domain; Region: Cna_B; pfam05738 1052588010597 Cna protein B-type domain; Region: Cna_B; pfam05738 1052588010598 Cna protein B-type domain; Region: Cna_B; pfam05738 1052588010599 Cna protein B-type domain; Region: Cna_B; pfam05738 1052588010600 Cna protein B-type domain; Region: Cna_B; pfam05738 1052588010601 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1052588010602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588010603 active site 1052588010604 phosphorylation site [posttranslational modification] 1052588010605 intermolecular recognition site; other site 1052588010606 dimerization interface [polypeptide binding]; other site 1052588010607 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1052588010608 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1052588010609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052588010610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588010611 dimer interface [polypeptide binding]; other site 1052588010612 phosphorylation site [posttranslational modification] 1052588010613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588010614 ATP binding site [chemical binding]; other site 1052588010615 Mg2+ binding site [ion binding]; other site 1052588010616 G-X-G motif; other site 1052588010617 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1052588010618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588010619 active site 1052588010620 phosphorylation site [posttranslational modification] 1052588010621 intermolecular recognition site; other site 1052588010622 dimerization interface [polypeptide binding]; other site 1052588010623 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052588010624 Histidine kinase; Region: His_kinase; pfam06580 1052588010625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588010626 ATP binding site [chemical binding]; other site 1052588010627 Mg2+ binding site [ion binding]; other site 1052588010628 G-X-G motif; other site 1052588010629 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1052588010630 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1052588010631 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1052588010632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588010633 binding surface 1052588010634 TPR motif; other site 1052588010635 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052588010636 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1052588010637 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1052588010638 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1052588010639 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1052588010640 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1052588010641 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1052588010642 MreB and similar proteins; Region: MreB_like; cd10225 1052588010643 nucleotide binding site [chemical binding]; other site 1052588010644 Mg binding site [ion binding]; other site 1052588010645 putative protofilament interaction site [polypeptide binding]; other site 1052588010646 RodZ interaction site [polypeptide binding]; other site 1052588010647 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1052588010648 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588010649 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588010650 putative Zn2+ binding site [ion binding]; other site 1052588010651 putative DNA binding site [nucleotide binding]; other site 1052588010652 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588010653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010654 putative substrate translocation pore; other site 1052588010655 Right handed beta helix region; Region: Beta_helix; pfam13229 1052588010656 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1052588010657 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1052588010658 Na binding site [ion binding]; other site 1052588010659 putative substrate binding site [chemical binding]; other site 1052588010660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588010662 putative substrate translocation pore; other site 1052588010663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010664 Isochorismatase family; Region: Isochorismatase; pfam00857 1052588010665 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1052588010666 catalytic triad [active] 1052588010667 conserved cis-peptide bond; other site 1052588010668 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1052588010669 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1052588010670 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1052588010671 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1052588010672 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1052588010673 active site 1052588010674 VanZ like family; Region: VanZ; pfam04892 1052588010675 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1052588010676 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052588010677 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052588010678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588010679 Coenzyme A binding pocket [chemical binding]; other site 1052588010680 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1052588010681 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1052588010682 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052588010683 putative active site [active] 1052588010684 catalytic site [active] 1052588010685 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052588010686 putative active site [active] 1052588010687 catalytic site [active] 1052588010688 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1052588010689 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052588010690 DNA binding residues [nucleotide binding] 1052588010691 dimer interface [polypeptide binding]; other site 1052588010692 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1052588010693 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1052588010694 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052588010695 NAD binding site [chemical binding]; other site 1052588010696 substrate binding site [chemical binding]; other site 1052588010697 putative active site [active] 1052588010698 Predicted transcriptional regulator [Transcription]; Region: COG1959 1052588010699 Transcriptional regulator; Region: Rrf2; pfam02082 1052588010700 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1052588010701 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1052588010702 subunit interactions [polypeptide binding]; other site 1052588010703 active site 1052588010704 flap region; other site 1052588010705 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1052588010706 gamma-beta subunit interface [polypeptide binding]; other site 1052588010707 alpha-beta subunit interface [polypeptide binding]; other site 1052588010708 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1052588010709 alpha-gamma subunit interface [polypeptide binding]; other site 1052588010710 beta-gamma subunit interface [polypeptide binding]; other site 1052588010711 potential frameshift: common BLAST hit: gi|350267927|ref|YP_004879234.1| ABC transporter 1052588010712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588010713 Walker B; other site 1052588010714 D-loop; other site 1052588010715 H-loop/switch region; other site 1052588010716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588010717 Walker A/P-loop; other site 1052588010718 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052588010719 CsbD-like; Region: CsbD; pfam05532 1052588010720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588010721 binding surface 1052588010722 TPR motif; other site 1052588010723 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588010724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588010725 binding surface 1052588010726 TPR motif; other site 1052588010727 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1052588010728 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588010729 FeS/SAM binding site; other site 1052588010730 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1052588010731 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1052588010732 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1052588010733 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1052588010734 metal ion-dependent adhesion site (MIDAS); other site 1052588010735 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1052588010736 metal ion-dependent adhesion site (MIDAS); other site 1052588010737 stage II sporulation protein D; Region: spore_II_D; TIGR02870 1052588010738 Stage II sporulation protein; Region: SpoIID; pfam08486 1052588010739 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1052588010740 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1052588010741 hinge; other site 1052588010742 active site 1052588010743 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1052588010744 Predicted membrane protein [Function unknown]; Region: COG4836 1052588010745 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1052588010746 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1052588010747 gamma subunit interface [polypeptide binding]; other site 1052588010748 epsilon subunit interface [polypeptide binding]; other site 1052588010749 LBP interface [polypeptide binding]; other site 1052588010750 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1052588010751 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1052588010752 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1052588010753 alpha subunit interaction interface [polypeptide binding]; other site 1052588010754 Walker A motif; other site 1052588010755 ATP binding site [chemical binding]; other site 1052588010756 Walker B motif; other site 1052588010757 inhibitor binding site; inhibition site 1052588010758 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1052588010759 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1052588010760 core domain interface [polypeptide binding]; other site 1052588010761 delta subunit interface [polypeptide binding]; other site 1052588010762 epsilon subunit interface [polypeptide binding]; other site 1052588010763 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1052588010764 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1052588010765 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1052588010766 beta subunit interaction interface [polypeptide binding]; other site 1052588010767 Walker A motif; other site 1052588010768 ATP binding site [chemical binding]; other site 1052588010769 Walker B motif; other site 1052588010770 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1052588010771 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1052588010772 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1052588010773 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1052588010774 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1052588010775 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1052588010776 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1052588010777 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1052588010778 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588010779 active site 1052588010780 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1052588010781 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1052588010782 dimer interface [polypeptide binding]; other site 1052588010783 active site 1052588010784 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1052588010785 folate binding site [chemical binding]; other site 1052588010786 hypothetical protein; Provisional; Region: PRK13690 1052588010787 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1052588010788 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052588010789 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1052588010790 active site 1052588010791 Predicted membrane protein [Function unknown]; Region: COG1971 1052588010792 Domain of unknown function DUF; Region: DUF204; pfam02659 1052588010793 Domain of unknown function DUF; Region: DUF204; pfam02659 1052588010794 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1052588010795 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1052588010796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052588010797 HemK family putative methylases; Region: hemK_fam; TIGR00536 1052588010798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588010799 S-adenosylmethionine binding site [chemical binding]; other site 1052588010800 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1052588010801 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1052588010802 RF-1 domain; Region: RF-1; pfam00472 1052588010803 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1052588010804 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588010805 putative metal binding site [ion binding]; other site 1052588010806 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1052588010807 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1052588010808 DNA binding residues [nucleotide binding] 1052588010809 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1052588010810 malate dehydrogenase; Provisional; Region: PRK13529 1052588010811 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052588010812 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1052588010813 NAD(P) binding site [chemical binding]; other site 1052588010814 thymidine kinase; Provisional; Region: PRK04296 1052588010815 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1052588010816 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1052588010817 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1052588010818 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1052588010819 RNA binding site [nucleotide binding]; other site 1052588010820 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1052588010821 multimer interface [polypeptide binding]; other site 1052588010822 Walker A motif; other site 1052588010823 ATP binding site [chemical binding]; other site 1052588010824 Walker B motif; other site 1052588010825 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1052588010826 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1052588010827 putative active site [active] 1052588010828 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1052588010829 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1052588010830 hinge; other site 1052588010831 active site 1052588010832 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1052588010833 active site 1052588010834 intersubunit interactions; other site 1052588010835 catalytic residue [active] 1052588010836 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1052588010837 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1052588010838 intersubunit interface [polypeptide binding]; other site 1052588010839 active site 1052588010840 zinc binding site [ion binding]; other site 1052588010841 Na+ binding site [ion binding]; other site 1052588010842 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588010843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588010844 active site 1052588010845 phosphorylation site [posttranslational modification] 1052588010846 intermolecular recognition site; other site 1052588010847 dimerization interface [polypeptide binding]; other site 1052588010848 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1052588010849 CTP synthetase; Validated; Region: pyrG; PRK05380 1052588010850 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1052588010851 Catalytic site [active] 1052588010852 active site 1052588010853 UTP binding site [chemical binding]; other site 1052588010854 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1052588010855 active site 1052588010856 putative oxyanion hole; other site 1052588010857 catalytic triad [active] 1052588010858 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1052588010859 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052588010860 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1052588010861 FAD binding site [chemical binding]; other site 1052588010862 homotetramer interface [polypeptide binding]; other site 1052588010863 substrate binding pocket [chemical binding]; other site 1052588010864 catalytic base [active] 1052588010865 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1052588010866 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1052588010867 Cysteine-rich domain; Region: CCG; pfam02754 1052588010868 Cysteine-rich domain; Region: CCG; pfam02754 1052588010869 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052588010870 putative active site [active] 1052588010871 catalytic site [active] 1052588010872 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052588010873 PLD-like domain; Region: PLDc_2; pfam13091 1052588010874 putative active site [active] 1052588010875 catalytic site [active] 1052588010876 UV-endonuclease UvdE; Region: UvdE; cl10036 1052588010877 RibD C-terminal domain; Region: RibD_C; cl17279 1052588010878 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1052588010879 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588010880 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052588010881 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1052588010882 Walker A/P-loop; other site 1052588010883 ATP binding site [chemical binding]; other site 1052588010884 Q-loop/lid; other site 1052588010885 ABC transporter signature motif; other site 1052588010886 Walker B; other site 1052588010887 D-loop; other site 1052588010888 H-loop/switch region; other site 1052588010889 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1052588010890 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052588010891 putative active site [active] 1052588010892 catalytic site [active] 1052588010893 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052588010894 putative active site [active] 1052588010895 catalytic site [active] 1052588010896 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1052588010897 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1052588010898 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1052588010899 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1052588010900 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1052588010901 [4Fe-4S] binding site [ion binding]; other site 1052588010902 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052588010903 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052588010904 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052588010905 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1052588010906 molybdopterin cofactor binding site; other site 1052588010907 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1052588010908 ligand binding site [chemical binding]; other site 1052588010909 flexible hinge region; other site 1052588010910 YwiC-like protein; Region: YwiC; pfam14256 1052588010911 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1052588010912 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1052588010913 ligand binding site [chemical binding]; other site 1052588010914 flexible hinge region; other site 1052588010915 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1052588010916 putative switch regulator; other site 1052588010917 non-specific DNA interactions [nucleotide binding]; other site 1052588010918 DNA binding site [nucleotide binding] 1052588010919 sequence specific DNA binding site [nucleotide binding]; other site 1052588010920 putative cAMP binding site [chemical binding]; other site 1052588010921 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1052588010922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010923 putative substrate translocation pore; other site 1052588010924 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1052588010925 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1052588010926 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1052588010927 active site 1052588010928 HIGH motif; other site 1052588010929 KMSK motif region; other site 1052588010930 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1052588010931 tRNA binding surface [nucleotide binding]; other site 1052588010932 anticodon binding site; other site 1052588010933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1052588010934 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 1052588010935 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1052588010936 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1052588010937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588010938 FeS/SAM binding site; other site 1052588010939 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1052588010940 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1052588010941 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052588010942 Walker A/P-loop; other site 1052588010943 ATP binding site [chemical binding]; other site 1052588010944 Q-loop/lid; other site 1052588010945 ABC transporter signature motif; other site 1052588010946 Walker B; other site 1052588010947 D-loop; other site 1052588010948 H-loop/switch region; other site 1052588010949 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052588010950 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052588010951 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052588010952 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052588010953 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1052588010954 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1052588010955 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1052588010956 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1052588010957 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1052588010958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588010959 binding surface 1052588010960 TPR motif; other site 1052588010961 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588010962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052588010963 binding surface 1052588010964 TPR motif; other site 1052588010965 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1052588010966 putative deacylase active site [active] 1052588010967 agmatinase; Region: agmatinase; TIGR01230 1052588010968 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1052588010969 putative active site [active] 1052588010970 Mn binding site [ion binding]; other site 1052588010971 spermidine synthase; Provisional; Region: PRK00811 1052588010972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588010973 Transglycosylase; Region: Transgly; pfam00912 1052588010974 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052588010975 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1052588010976 YwhD family; Region: YwhD; pfam08741 1052588010977 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1052588010978 Peptidase family M50; Region: Peptidase_M50; pfam02163 1052588010979 active site 1052588010980 putative substrate binding region [chemical binding]; other site 1052588010981 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1052588010982 active site 1 [active] 1052588010983 dimer interface [polypeptide binding]; other site 1052588010984 hexamer interface [polypeptide binding]; other site 1052588010985 active site 2 [active] 1052588010986 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588010987 MarR family; Region: MarR; pfam01047 1052588010988 MarR family; Region: MarR_2; cl17246 1052588010989 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 1052588010990 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1052588010991 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1052588010992 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1052588010993 active site 1052588010994 dimer interface [polypeptide binding]; other site 1052588010995 motif 1; other site 1052588010996 motif 2; other site 1052588010997 motif 3; other site 1052588010998 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1052588010999 anticodon binding site; other site 1052588011000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011001 D-galactonate transporter; Region: 2A0114; TIGR00893 1052588011002 putative substrate translocation pore; other site 1052588011003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011004 Rrf2 family protein; Region: rrf2_super; TIGR00738 1052588011005 Transcriptional regulator; Region: Rrf2; pfam02082 1052588011006 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1052588011007 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1052588011008 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052588011009 Zn2+ binding site [ion binding]; other site 1052588011010 Mg2+ binding site [ion binding]; other site 1052588011011 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1052588011012 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1052588011013 EamA-like transporter family; Region: EamA; pfam00892 1052588011014 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052588011015 EamA-like transporter family; Region: EamA; pfam00892 1052588011016 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1052588011017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588011018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588011019 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1052588011020 putative dimerization interface [polypeptide binding]; other site 1052588011021 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1052588011022 putative heme peroxidase; Provisional; Region: PRK12276 1052588011023 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052588011024 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1052588011025 putative NAD(P) binding site [chemical binding]; other site 1052588011026 putative active site [active] 1052588011027 transaminase; Reviewed; Region: PRK08068 1052588011028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588011029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588011030 homodimer interface [polypeptide binding]; other site 1052588011031 catalytic residue [active] 1052588011032 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052588011033 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1052588011034 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1052588011035 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052588011036 classical (c) SDRs; Region: SDR_c; cd05233 1052588011037 NAD(P) binding site [chemical binding]; other site 1052588011038 active site 1052588011039 Cupin domain; Region: Cupin_2; pfam07883 1052588011040 Cupin domain; Region: Cupin_2; pfam07883 1052588011041 Prephenate dehydratase; Region: PDT; pfam00800 1052588011042 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588011043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011044 putative substrate translocation pore; other site 1052588011045 S-methylmethionine transporter; Provisional; Region: PRK11387 1052588011046 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1052588011047 putative metal binding site [ion binding]; other site 1052588011048 putative dimer interface [polypeptide binding]; other site 1052588011049 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1052588011050 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1052588011051 Glutamate binding site [chemical binding]; other site 1052588011052 homodimer interface [polypeptide binding]; other site 1052588011053 NAD binding site [chemical binding]; other site 1052588011054 catalytic residues [active] 1052588011055 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1052588011056 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1052588011057 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1052588011058 NAD(P) binding site [chemical binding]; other site 1052588011059 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1052588011060 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1052588011061 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 1052588011062 NAD binding site [chemical binding]; other site 1052588011063 substrate binding site [chemical binding]; other site 1052588011064 homodimer interface [polypeptide binding]; other site 1052588011065 active site 1052588011066 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1052588011067 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1052588011068 substrate binding site; other site 1052588011069 tetramer interface; other site 1052588011070 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1052588011071 ligand binding site; other site 1052588011072 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1052588011073 NeuB family; Region: NeuB; pfam03102 1052588011074 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1052588011075 NeuB binding interface [polypeptide binding]; other site 1052588011076 putative substrate binding site [chemical binding]; other site 1052588011077 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052588011078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588011079 Coenzyme A binding pocket [chemical binding]; other site 1052588011080 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1052588011081 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1052588011082 inhibitor-cofactor binding pocket; inhibition site 1052588011083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588011084 catalytic residue [active] 1052588011085 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1052588011086 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1052588011087 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052588011088 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588011089 active site 1052588011090 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1052588011091 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1052588011092 Permease family; Region: Xan_ur_permease; pfam00860 1052588011093 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1052588011094 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1052588011095 NAD(P) binding site [chemical binding]; other site 1052588011096 catalytic residues [active] 1052588011097 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1052588011098 ligand binding site [chemical binding]; other site 1052588011099 active site 1052588011100 UGI interface [polypeptide binding]; other site 1052588011101 catalytic site [active] 1052588011102 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052588011103 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588011104 active site 1052588011105 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1052588011106 dimer interface [polypeptide binding]; other site 1052588011107 substrate binding site [chemical binding]; other site 1052588011108 ATP binding site [chemical binding]; other site 1052588011109 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1052588011110 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052588011111 substrate binding [chemical binding]; other site 1052588011112 active site 1052588011113 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052588011114 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1052588011115 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588011116 active site turn [active] 1052588011117 phosphorylation site [posttranslational modification] 1052588011118 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052588011119 formate/nitrite transporter; Region: fnt; TIGR00790 1052588011120 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1052588011121 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052588011122 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1052588011123 putative active site [active] 1052588011124 catalytic triad [active] 1052588011125 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1052588011126 PA/protease domain interface [polypeptide binding]; other site 1052588011127 putative integrin binding motif; other site 1052588011128 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1052588011129 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1052588011130 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1052588011131 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052588011132 Bacterial protein of unknown function (HtrL_YibB); Region: HtrL_YibB; cl08171 1052588011133 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1052588011134 dimer interface [polypeptide binding]; other site 1052588011135 FMN binding site [chemical binding]; other site 1052588011136 NADPH bind site [chemical binding]; other site 1052588011137 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1052588011138 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1052588011139 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1052588011140 Subunit I/III interface [polypeptide binding]; other site 1052588011141 Subunit III/IV interface [polypeptide binding]; other site 1052588011142 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1052588011143 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1052588011144 D-pathway; other site 1052588011145 Putative ubiquinol binding site [chemical binding]; other site 1052588011146 Low-spin heme (heme b) binding site [chemical binding]; other site 1052588011147 Putative water exit pathway; other site 1052588011148 Binuclear center (heme o3/CuB) [ion binding]; other site 1052588011149 K-pathway; other site 1052588011150 Putative proton exit pathway; other site 1052588011151 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1052588011152 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1052588011153 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1052588011154 Predicted membrane protein [Function unknown]; Region: COG2261 1052588011155 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 1052588011156 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1052588011157 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1052588011158 galactokinase; Provisional; Region: PRK05322 1052588011159 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1052588011160 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1052588011161 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052588011162 Predicted membrane protein [Function unknown]; Region: COG2246 1052588011163 GtrA-like protein; Region: GtrA; pfam04138 1052588011164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588011165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588011166 Anti-repressor SinI; Region: SinI; pfam08671 1052588011167 Predicted membrane protein [Function unknown]; Region: COG3162 1052588011168 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1052588011169 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1052588011170 Na binding site [ion binding]; other site 1052588011171 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1052588011172 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1052588011173 catalytic residues [active] 1052588011174 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1052588011175 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1052588011176 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1052588011177 Imelysin; Region: Peptidase_M75; pfam09375 1052588011178 Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases; Region: HR1; cl00087 1052588011179 FTR1 family protein; Region: TIGR00145 1052588011180 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1052588011181 thiamine phosphate binding site [chemical binding]; other site 1052588011182 active site 1052588011183 pyrophosphate binding site [ion binding]; other site 1052588011184 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1052588011185 substrate binding site [chemical binding]; other site 1052588011186 multimerization interface [polypeptide binding]; other site 1052588011187 ATP binding site [chemical binding]; other site 1052588011188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588011189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588011190 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1052588011191 putative dimerization interface [polypeptide binding]; other site 1052588011192 holin-like protein; Validated; Region: PRK01658 1052588011193 TIGR00659 family protein; Region: TIGR00659 1052588011194 sugar efflux transporter; Region: 2A0120; TIGR00899 1052588011195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011196 putative substrate translocation pore; other site 1052588011197 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1052588011198 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1052588011199 PUA domain; Region: PUA; cl00607 1052588011200 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1052588011201 putative RNA binding site [nucleotide binding]; other site 1052588011202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588011203 S-adenosylmethionine binding site [chemical binding]; other site 1052588011204 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588011205 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052588011206 active site 1052588011207 metal binding site [ion binding]; metal-binding site 1052588011208 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052588011209 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1052588011210 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052588011211 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052588011212 active site 1052588011213 catalytic residues [active] 1052588011214 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1052588011215 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588011216 active site turn [active] 1052588011217 phosphorylation site [posttranslational modification] 1052588011218 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052588011219 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052588011220 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1052588011221 PRD domain; Region: PRD; pfam00874 1052588011222 PRD domain; Region: PRD; pfam00874 1052588011223 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1052588011224 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1052588011225 Ligand binding site; other site 1052588011226 metal-binding site 1052588011227 Predicted integral membrane protein [Function unknown]; Region: COG5522 1052588011228 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588011229 MarR family; Region: MarR; pfam01047 1052588011230 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1052588011231 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1052588011232 active site 1052588011233 HIGH motif; other site 1052588011234 dimer interface [polypeptide binding]; other site 1052588011235 KMSKS motif; other site 1052588011236 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588011237 RNA binding surface [nucleotide binding]; other site 1052588011238 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1052588011239 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1052588011240 PA/protease domain interface [polypeptide binding]; other site 1052588011241 putative integrin binding motif; other site 1052588011242 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1052588011243 Peptidase family M28; Region: Peptidase_M28; pfam04389 1052588011244 metal binding site [ion binding]; metal-binding site 1052588011245 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052588011246 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1052588011247 synthetase active site [active] 1052588011248 NTP binding site [chemical binding]; other site 1052588011249 metal binding site [ion binding]; metal-binding site 1052588011250 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1052588011251 UbiA prenyltransferase family; Region: UbiA; pfam01040 1052588011252 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1052588011253 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1052588011254 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1052588011255 acyl-activating enzyme (AAE) consensus motif; other site 1052588011256 AMP binding site [chemical binding]; other site 1052588011257 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1052588011258 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1052588011259 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1052588011260 DltD N-terminal region; Region: DltD_N; pfam04915 1052588011261 DltD central region; Region: DltD_M; pfam04918 1052588011262 DltD C-terminal region; Region: DltD_C; pfam04914 1052588011263 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1052588011264 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1052588011265 putative NAD(P) binding site [chemical binding]; other site 1052588011266 active site 1052588011267 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1052588011268 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1052588011269 homodimer interface [polypeptide binding]; other site 1052588011270 substrate-cofactor binding pocket; other site 1052588011271 catalytic residue [active] 1052588011272 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1052588011273 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1052588011274 NAD binding site [chemical binding]; other site 1052588011275 sugar binding site [chemical binding]; other site 1052588011276 divalent metal binding site [ion binding]; other site 1052588011277 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588011278 dimer interface [polypeptide binding]; other site 1052588011279 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1052588011280 methionine cluster; other site 1052588011281 active site 1052588011282 phosphorylation site [posttranslational modification] 1052588011283 metal binding site [ion binding]; metal-binding site 1052588011284 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052588011285 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1052588011286 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1052588011287 active site 1052588011288 P-loop; other site 1052588011289 phosphorylation site [posttranslational modification] 1052588011290 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052588011291 HTH domain; Region: HTH_11; pfam08279 1052588011292 Mga helix-turn-helix domain; Region: Mga; pfam05043 1052588011293 PRD domain; Region: PRD; pfam00874 1052588011294 PRD domain; Region: PRD; pfam00874 1052588011295 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052588011296 active site 1052588011297 P-loop; other site 1052588011298 phosphorylation site [posttranslational modification] 1052588011299 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052588011300 active site 1052588011301 phosphorylation site [posttranslational modification] 1052588011302 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1052588011303 active site 1052588011304 DNA binding site [nucleotide binding] 1052588011305 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1052588011306 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1052588011307 tetramer interface [polypeptide binding]; other site 1052588011308 heme binding pocket [chemical binding]; other site 1052588011309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011310 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588011311 putative substrate translocation pore; other site 1052588011312 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1052588011313 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052588011314 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052588011315 Walker A/P-loop; other site 1052588011316 ATP binding site [chemical binding]; other site 1052588011317 Q-loop/lid; other site 1052588011318 ABC transporter signature motif; other site 1052588011319 Walker B; other site 1052588011320 D-loop; other site 1052588011321 H-loop/switch region; other site 1052588011322 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1052588011323 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1052588011324 Exoribonuclease II [Transcription]; Region: Rnb; COG4776 1052588011325 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 1052588011326 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588011327 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588011328 DNA binding residues [nucleotide binding] 1052588011329 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1052588011330 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1052588011331 Na binding site [ion binding]; other site 1052588011332 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1052588011333 putative substrate binding site [chemical binding]; other site 1052588011334 putative ATP binding site [chemical binding]; other site 1052588011335 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1052588011336 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052588011337 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1052588011338 Walker A/P-loop; other site 1052588011339 ATP binding site [chemical binding]; other site 1052588011340 Q-loop/lid; other site 1052588011341 ABC transporter signature motif; other site 1052588011342 Walker B; other site 1052588011343 D-loop; other site 1052588011344 H-loop/switch region; other site 1052588011345 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1052588011346 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052588011347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588011348 ATP binding site [chemical binding]; other site 1052588011349 Q-loop/lid; other site 1052588011350 ABC transporter signature motif; other site 1052588011351 Walker B; other site 1052588011352 D-loop; other site 1052588011353 H-loop/switch region; other site 1052588011354 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1052588011355 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1052588011356 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1052588011357 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1052588011358 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1052588011359 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1052588011360 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052588011361 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1052588011362 putative active site [active] 1052588011363 putative metal binding site [ion binding]; other site 1052588011364 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1052588011365 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1052588011366 Walker A/P-loop; other site 1052588011367 ATP binding site [chemical binding]; other site 1052588011368 Q-loop/lid; other site 1052588011369 ABC transporter signature motif; other site 1052588011370 Walker B; other site 1052588011371 D-loop; other site 1052588011372 H-loop/switch region; other site 1052588011373 TOBE domain; Region: TOBE; pfam03459 1052588011374 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052588011375 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1052588011376 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1052588011377 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052588011378 NAD(P) binding site [chemical binding]; other site 1052588011379 catalytic residues [active] 1052588011380 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052588011381 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588011382 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052588011383 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1052588011384 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052588011385 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1052588011386 UDP-glucose 4-epimerase; Region: PLN02240 1052588011387 NAD binding site [chemical binding]; other site 1052588011388 homodimer interface [polypeptide binding]; other site 1052588011389 active site 1052588011390 substrate binding site [chemical binding]; other site 1052588011391 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1052588011392 substrate binding site [chemical binding]; other site 1052588011393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588011394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588011395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588011396 dimerization interface [polypeptide binding]; other site 1052588011397 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588011398 Histidine kinase; Region: HisKA_3; pfam07730 1052588011399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588011400 ATP binding site [chemical binding]; other site 1052588011401 Mg2+ binding site [ion binding]; other site 1052588011402 G-X-G motif; other site 1052588011403 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588011404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588011405 active site 1052588011406 phosphorylation site [posttranslational modification] 1052588011407 intermolecular recognition site; other site 1052588011408 dimerization interface [polypeptide binding]; other site 1052588011409 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588011410 DNA binding residues [nucleotide binding] 1052588011411 dimerization interface [polypeptide binding]; other site 1052588011412 peptidase T; Region: peptidase-T; TIGR01882 1052588011413 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1052588011414 metal binding site [ion binding]; metal-binding site 1052588011415 dimer interface [polypeptide binding]; other site 1052588011416 Tubby C 2; Region: Tub_2; cl02043 1052588011417 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052588011418 substrate binding site [chemical binding]; other site 1052588011419 THF binding site; other site 1052588011420 zinc-binding site [ion binding]; other site 1052588011421 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052588011422 substrate binding site [chemical binding]; other site 1052588011423 THF binding site; other site 1052588011424 zinc-binding site [ion binding]; other site 1052588011425 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1052588011426 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1052588011427 NAD binding site [chemical binding]; other site 1052588011428 homotetramer interface [polypeptide binding]; other site 1052588011429 homodimer interface [polypeptide binding]; other site 1052588011430 substrate binding site [chemical binding]; other site 1052588011431 active site 1052588011432 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1052588011433 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1052588011434 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1052588011435 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1052588011436 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1052588011437 S-adenosylmethionine binding site [chemical binding]; other site 1052588011438 nucleoside transporter; Region: nupC; TIGR00804 1052588011439 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1052588011440 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1052588011441 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052588011442 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1052588011443 hydroperoxidase II; Provisional; Region: katE; PRK11249 1052588011444 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1052588011445 tetramer interface [polypeptide binding]; other site 1052588011446 heme binding pocket [chemical binding]; other site 1052588011447 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1052588011448 domain interactions; other site 1052588011449 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1052588011450 Citrate transporter; Region: CitMHS; pfam03600 1052588011451 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1052588011452 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1052588011453 active site 1052588011454 active site 1052588011455 catalytic residues [active] 1052588011456 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052588011457 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1052588011458 PRD domain; Region: PRD; pfam00874 1052588011459 PRD domain; Region: PRD; pfam00874 1052588011460 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1052588011461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011462 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1052588011463 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052588011464 ATP binding site [chemical binding]; other site 1052588011465 Mg++ binding site [ion binding]; other site 1052588011466 motif III; other site 1052588011467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588011468 nucleotide binding region [chemical binding]; other site 1052588011469 ATP-binding site [chemical binding]; other site 1052588011470 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1052588011471 RNA binding site [nucleotide binding]; other site 1052588011472 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1052588011473 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052588011474 active site 1052588011475 catalytic triad [active] 1052588011476 Predicted transcriptional regulators [Transcription]; Region: COG1695 1052588011477 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1052588011478 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1052588011479 RHS Repeat; Region: RHS_repeat; pfam05593 1052588011480 RHS Repeat; Region: RHS_repeat; pfam05593 1052588011481 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1052588011482 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1052588011483 RHS Repeat; Region: RHS_repeat; pfam05593 1052588011484 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1052588011485 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1052588011486 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052588011487 EamA-like transporter family; Region: EamA; pfam00892 1052588011488 EamA-like transporter family; Region: EamA; pfam00892 1052588011489 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1052588011490 Ligand Binding Site [chemical binding]; other site 1052588011491 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1052588011492 beta-galactosidase; Region: BGL; TIGR03356 1052588011493 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052588011494 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588011495 active site turn [active] 1052588011496 phosphorylation site [posttranslational modification] 1052588011497 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052588011498 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1052588011499 HPr interaction site; other site 1052588011500 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052588011501 active site 1052588011502 phosphorylation site [posttranslational modification] 1052588011503 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1052588011504 metal ion-dependent adhesion site (MIDAS); other site 1052588011505 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052588011506 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1052588011507 active site 1052588011508 8-oxo-dGMP binding site [chemical binding]; other site 1052588011509 nudix motif; other site 1052588011510 metal binding site [ion binding]; metal-binding site 1052588011511 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1052588011512 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1052588011513 substrate binding site [chemical binding]; other site 1052588011514 active site 1052588011515 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1052588011516 hexamer interface [polypeptide binding]; other site 1052588011517 RNA binding site [nucleotide binding]; other site 1052588011518 Histidine-zinc binding site [chemical binding]; other site 1052588011519 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1052588011520 active sites [active] 1052588011521 tetramer interface [polypeptide binding]; other site 1052588011522 urocanate hydratase; Provisional; Region: PRK05414 1052588011523 imidazolonepropionase; Validated; Region: PRK09356 1052588011524 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1052588011525 active site 1052588011526 Agmatinase-like family; Region: Agmatinase-like; cd09990 1052588011527 agmatinase; Region: agmatinase; TIGR01230 1052588011528 active site 1052588011529 oligomer interface [polypeptide binding]; other site 1052588011530 Mn binding site [ion binding]; other site 1052588011531 S-methylmethionine transporter; Provisional; Region: PRK11387 1052588011532 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1052588011533 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1052588011534 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1052588011535 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1052588011536 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1052588011537 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1052588011538 Nucleoside recognition; Region: Gate; pfam07670 1052588011539 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1052588011540 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1052588011541 intersubunit interface [polypeptide binding]; other site 1052588011542 active site 1052588011543 catalytic residue [active] 1052588011544 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1052588011545 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588011546 DNA binding residues [nucleotide binding] 1052588011547 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1052588011548 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1052588011549 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1052588011550 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1052588011551 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1052588011552 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 1052588011553 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052588011554 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1052588011555 metal binding site [ion binding]; metal-binding site 1052588011556 dimer interface [polypeptide binding]; other site 1052588011557 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052588011558 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052588011559 Walker A/P-loop; other site 1052588011560 ATP binding site [chemical binding]; other site 1052588011561 Q-loop/lid; other site 1052588011562 ABC transporter signature motif; other site 1052588011563 Walker B; other site 1052588011564 D-loop; other site 1052588011565 H-loop/switch region; other site 1052588011566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588011567 dimer interface [polypeptide binding]; other site 1052588011568 conserved gate region; other site 1052588011569 putative PBP binding loops; other site 1052588011570 ABC-ATPase subunit interface; other site 1052588011571 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052588011572 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052588011573 substrate binding pocket [chemical binding]; other site 1052588011574 membrane-bound complex binding site; other site 1052588011575 hinge residues; other site 1052588011576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588011577 Coenzyme A binding pocket [chemical binding]; other site 1052588011578 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1052588011579 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1052588011580 active site 1052588011581 non-prolyl cis peptide bond; other site 1052588011582 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1052588011583 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1052588011584 active site 1052588011585 sugar phosphate phosphatase; Provisional; Region: PRK10513 1052588011586 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588011587 active site 1052588011588 motif I; other site 1052588011589 motif II; other site 1052588011590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588011591 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1052588011592 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1052588011593 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1052588011594 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052588011595 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052588011596 putative ligand binding residues [chemical binding]; other site 1052588011597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1052588011598 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588011599 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052588011600 Walker A/P-loop; other site 1052588011601 ATP binding site [chemical binding]; other site 1052588011602 Q-loop/lid; other site 1052588011603 ABC transporter signature motif; other site 1052588011604 Walker B; other site 1052588011605 D-loop; other site 1052588011606 H-loop/switch region; other site 1052588011607 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052588011608 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1052588011609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588011610 ATP binding site [chemical binding]; other site 1052588011611 Mg2+ binding site [ion binding]; other site 1052588011612 G-X-G motif; other site 1052588011613 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588011614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588011615 active site 1052588011616 phosphorylation site [posttranslational modification] 1052588011617 intermolecular recognition site; other site 1052588011618 dimerization interface [polypeptide binding]; other site 1052588011619 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588011620 DNA binding site [nucleotide binding] 1052588011621 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1052588011622 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1052588011623 intersubunit interface [polypeptide binding]; other site 1052588011624 active site 1052588011625 zinc binding site [ion binding]; other site 1052588011626 Na+ binding site [ion binding]; other site 1052588011627 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052588011628 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1052588011629 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052588011630 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1052588011631 DNA interaction; other site 1052588011632 Metal-binding active site; metal-binding site 1052588011633 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588011634 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052588011635 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052588011636 Glucuronate isomerase; Region: UxaC; cl00829 1052588011637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011638 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588011639 putative substrate translocation pore; other site 1052588011640 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052588011641 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1052588011642 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052588011643 PYR/PP interface [polypeptide binding]; other site 1052588011644 dimer interface [polypeptide binding]; other site 1052588011645 TPP binding site [chemical binding]; other site 1052588011646 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1052588011647 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1052588011648 TPP-binding site; other site 1052588011649 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052588011650 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1052588011651 substrate binding site [chemical binding]; other site 1052588011652 ATP binding site [chemical binding]; other site 1052588011653 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1052588011654 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1052588011655 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052588011656 tetrameric interface [polypeptide binding]; other site 1052588011657 NAD binding site [chemical binding]; other site 1052588011658 catalytic residues [active] 1052588011659 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052588011660 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1052588011661 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1052588011662 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588011663 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052588011664 active site 1052588011665 catalytic tetrad [active] 1052588011666 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1052588011667 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1052588011668 CGNR zinc finger; Region: zf-CGNR; pfam11706 1052588011669 HPP family; Region: HPP; pfam04982 1052588011670 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052588011671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011672 putative substrate translocation pore; other site 1052588011673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011674 heat shock protein 90; Provisional; Region: PRK05218 1052588011675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588011676 ATP binding site [chemical binding]; other site 1052588011677 Mg2+ binding site [ion binding]; other site 1052588011678 G-X-G motif; other site 1052588011679 short chain dehydrogenase; Validated; Region: PRK08589 1052588011680 classical (c) SDRs; Region: SDR_c; cd05233 1052588011681 NAD(P) binding site [chemical binding]; other site 1052588011682 active site 1052588011683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588011684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588011685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588011686 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1052588011687 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1052588011688 NAD(P) binding site [chemical binding]; other site 1052588011689 catalytic residues [active] 1052588011690 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1052588011691 catalytic tetrad [active] 1052588011692 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1052588011693 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052588011694 DNA binding residues [nucleotide binding] 1052588011695 putative dimer interface [polypeptide binding]; other site 1052588011696 RDD family; Region: RDD; pfam06271 1052588011697 Predicted membrane protein [Function unknown]; Region: COG2311 1052588011698 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1052588011699 Cupin domain; Region: Cupin_2; pfam07883 1052588011700 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1052588011701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588011702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052588011703 short chain dehydrogenase; Provisional; Region: PRK07109 1052588011704 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1052588011705 putative NAD(P) binding site [chemical binding]; other site 1052588011706 active site 1052588011707 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588011708 MarR family; Region: MarR; pfam01047 1052588011709 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1052588011710 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1052588011711 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1052588011712 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1052588011713 Glycerate kinase family; Region: Gly_kinase; pfam02595 1052588011714 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1052588011715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588011716 DNA-binding site [nucleotide binding]; DNA binding site 1052588011717 FCD domain; Region: FCD; pfam07729 1052588011718 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1052588011719 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1052588011720 N- and C-terminal domain interface [polypeptide binding]; other site 1052588011721 active site 1052588011722 catalytic site [active] 1052588011723 metal binding site [ion binding]; metal-binding site 1052588011724 carbohydrate binding site [chemical binding]; other site 1052588011725 ATP binding site [chemical binding]; other site 1052588011726 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1052588011727 gluconate transporter; Region: gntP; TIGR00791 1052588011728 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 1052588011729 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1052588011730 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1052588011731 peroxiredoxin; Region: AhpC; TIGR03137 1052588011732 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1052588011733 dimer interface [polypeptide binding]; other site 1052588011734 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1052588011735 catalytic triad [active] 1052588011736 peroxidatic and resolving cysteines [active] 1052588011737 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1052588011738 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1052588011739 catalytic residue [active] 1052588011740 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1052588011741 catalytic residues [active] 1052588011742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052588011743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588011744 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052588011745 beta-galactosidase; Region: BGL; TIGR03356 1052588011746 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052588011747 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588011748 active site turn [active] 1052588011749 phosphorylation site [posttranslational modification] 1052588011750 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052588011751 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052588011752 HPr interaction site; other site 1052588011753 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052588011754 active site 1052588011755 phosphorylation site [posttranslational modification] 1052588011756 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052588011757 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588011758 DNA-binding site [nucleotide binding]; DNA binding site 1052588011759 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1052588011760 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052588011761 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052588011762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052588011763 Walker A/P-loop; other site 1052588011764 ATP binding site [chemical binding]; other site 1052588011765 ABC transporter signature motif; other site 1052588011766 Walker B; other site 1052588011767 D-loop; other site 1052588011768 H-loop/switch region; other site 1052588011769 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 1052588011770 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588011771 FeS/SAM binding site; other site 1052588011772 exported signaling peptide, YydF/SAG_2028 family; Region: expor_sig_YdyF; TIGR04077 1052588011773 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1052588011774 HTH-like domain; Region: HTH_21; pfam13276 1052588011775 Integrase core domain; Region: rve; pfam00665 1052588011776 Protein of unknown function (DUF524); Region: DUF524; pfam04411 1052588011777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1052588011778 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1052588011779 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1052588011780 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1052588011781 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1052588011782 NAD binding site [chemical binding]; other site 1052588011783 catalytic Zn binding site [ion binding]; other site 1052588011784 structural Zn binding site [ion binding]; other site 1052588011785 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1052588011786 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1052588011787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052588011788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588011789 Coenzyme A binding pocket [chemical binding]; other site 1052588011790 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588011791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588011792 binding surface 1052588011793 TPR motif; other site 1052588011794 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588011795 Arginase family; Region: Arginase; cd09989 1052588011796 agmatinase; Region: agmatinase; TIGR01230 1052588011797 active site 1052588011798 Mn binding site [ion binding]; other site 1052588011799 oligomer interface [polypeptide binding]; other site 1052588011800 S-methylmethionine transporter; Provisional; Region: PRK11387 1052588011801 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1052588011802 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588011803 inhibitor-cofactor binding pocket; inhibition site 1052588011804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588011805 catalytic residue [active] 1052588011806 PAS domain; Region: PAS; smart00091 1052588011807 PAS domain; Region: PAS_9; pfam13426 1052588011808 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1052588011809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588011810 Walker A motif; other site 1052588011811 ATP binding site [chemical binding]; other site 1052588011812 Walker B motif; other site 1052588011813 arginine finger; other site 1052588011814 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1052588011815 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1052588011816 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1052588011817 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052588011818 protein binding site [polypeptide binding]; other site 1052588011819 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1052588011820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 1052588011821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1052588011822 YycH protein; Region: YycH; pfam07435 1052588011823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1052588011824 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588011825 dimerization interface [polypeptide binding]; other site 1052588011826 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588011827 putative active site [active] 1052588011828 heme pocket [chemical binding]; other site 1052588011829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588011830 dimer interface [polypeptide binding]; other site 1052588011831 phosphorylation site [posttranslational modification] 1052588011832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588011833 ATP binding site [chemical binding]; other site 1052588011834 Mg2+ binding site [ion binding]; other site 1052588011835 G-X-G motif; other site 1052588011836 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588011837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588011838 active site 1052588011839 phosphorylation site [posttranslational modification] 1052588011840 intermolecular recognition site; other site 1052588011841 dimerization interface [polypeptide binding]; other site 1052588011842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588011843 DNA binding site [nucleotide binding] 1052588011844 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1052588011845 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1052588011846 GDP-binding site [chemical binding]; other site 1052588011847 ACT binding site; other site 1052588011848 IMP binding site; other site 1052588011849 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588011850 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052588011851 active site 1052588011852 replicative DNA helicase; Provisional; Region: PRK05748 1052588011853 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1052588011854 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1052588011855 Walker A motif; other site 1052588011856 ATP binding site [chemical binding]; other site 1052588011857 Walker B motif; other site 1052588011858 DNA binding loops [nucleotide binding] 1052588011859 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1052588011860 YycC-like protein; Region: YycC; pfam14174 1052588011861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011862 cyanate transporter; Region: CynX; TIGR00896 1052588011863 putative substrate translocation pore; other site 1052588011864 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1052588011865 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1052588011866 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1052588011867 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1052588011868 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1052588011869 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1052588011870 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1052588011871 diguanylate cyclase; Region: GGDEF; smart00267 1052588011872 DHH family; Region: DHH; pfam01368 1052588011873 DHHA1 domain; Region: DHHA1; pfam02272 1052588011874 Predicted membrane protein [Function unknown]; Region: COG4241 1052588011875 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1052588011876 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052588011877 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052588011878 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1052588011879 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1052588011880 DHHA2 domain; Region: DHHA2; pfam02833 1052588011881 ANTAR domain; Region: ANTAR; cl04297 1052588011882 D-galactonate transporter; Region: 2A0114; TIGR00893 1052588011883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011884 putative substrate translocation pore; other site 1052588011885 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1052588011886 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052588011887 DNA binding residues [nucleotide binding] 1052588011888 dimer interface [polypeptide binding]; other site 1052588011889 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1052588011890 SnoaL-like domain; Region: SnoaL_3; pfam13474 1052588011891 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1052588011892 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052588011893 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052588011894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011895 putative substrate translocation pore; other site 1052588011896 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588011897 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588011898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588011899 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1052588011900 putative dimerization interface [polypeptide binding]; other site 1052588011901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588011902 Coenzyme A binding pocket [chemical binding]; other site 1052588011903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588011904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052588011905 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588011906 dimerization interface [polypeptide binding]; other site 1052588011907 LysE type translocator; Region: LysE; cl00565 1052588011908 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1052588011909 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588011910 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1052588011911 dimer interface [polypeptide binding]; other site 1052588011912 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052588011913 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588011914 MarR family; Region: MarR; pfam01047 1052588011915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588011916 Coenzyme A binding pocket [chemical binding]; other site 1052588011917 Predicted membrane protein [Function unknown]; Region: COG2364 1052588011918 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1052588011919 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1052588011920 catalytic residues [active] 1052588011921 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1052588011922 CAAX protease self-immunity; Region: Abi; pfam02517 1052588011923 benzoate transport; Region: 2A0115; TIGR00895 1052588011924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011925 putative substrate translocation pore; other site 1052588011926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011927 maltose O-acetyltransferase; Provisional; Region: PRK10092 1052588011928 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1052588011929 active site 1052588011930 substrate binding site [chemical binding]; other site 1052588011931 trimer interface [polypeptide binding]; other site 1052588011932 CoA binding site [chemical binding]; other site 1052588011933 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588011934 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1052588011935 putative metal binding site [ion binding]; other site 1052588011936 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588011937 DNA binding site [nucleotide binding] 1052588011938 domain linker motif; other site 1052588011939 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1052588011940 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1052588011941 putative dimerization interface [polypeptide binding]; other site 1052588011942 putative ligand binding site [chemical binding]; other site 1052588011943 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1052588011944 active site 1052588011945 putative catalytic site [active] 1052588011946 DNA binding site [nucleotide binding] 1052588011947 putative phosphate binding site [ion binding]; other site 1052588011948 metal binding site A [ion binding]; metal-binding site 1052588011949 AP binding site [nucleotide binding]; other site 1052588011950 metal binding site B [ion binding]; metal-binding site 1052588011951 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1052588011952 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1052588011953 dimer interface [polypeptide binding]; other site 1052588011954 ssDNA binding site [nucleotide binding]; other site 1052588011955 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588011956 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1052588011957 GTP-binding protein YchF; Reviewed; Region: PRK09601 1052588011958 YchF GTPase; Region: YchF; cd01900 1052588011959 G1 box; other site 1052588011960 GTP/Mg2+ binding site [chemical binding]; other site 1052588011961 Switch I region; other site 1052588011962 G2 box; other site 1052588011963 Switch II region; other site 1052588011964 G3 box; other site 1052588011965 G4 box; other site 1052588011966 G5 box; other site 1052588011967 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1052588011968 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1052588011969 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1052588011970 putative [4Fe-4S] binding site [ion binding]; other site 1052588011971 putative molybdopterin cofactor binding site [chemical binding]; other site 1052588011972 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1052588011973 molybdopterin cofactor binding site; other site 1052588011974 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1052588011975 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1052588011976 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1052588011977 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1052588011978 ParB-like nuclease domain; Region: ParB; smart00470 1052588011979 KorB domain; Region: KorB; pfam08535 1052588011980 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1052588011981 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1052588011982 P-loop; other site 1052588011983 Magnesium ion binding site [ion binding]; other site 1052588011984 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1052588011985 Magnesium ion binding site [ion binding]; other site 1052588011986 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1052588011987 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1052588011988 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1052588011989 ParB-like nuclease domain; Region: ParB; smart00470 1052588011990 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1052588011991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588011992 S-adenosylmethionine binding site [chemical binding]; other site 1052588011993 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1052588011994 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1052588011995 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1052588011996 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1052588011997 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1052588011998 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1052588011999 G1 box; other site 1052588012000 GTP/Mg2+ binding site [chemical binding]; other site 1052588012001 Switch I region; other site 1052588012002 G2 box; other site 1052588012003 Switch II region; other site 1052588012004 G3 box; other site 1052588012005 G4 box; other site 1052588012006 G5 box; other site 1052588012007 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1052588012008 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1052588012009 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1052588012010 G-X-X-G motif; other site 1052588012011 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1052588012012 RxxxH motif; other site 1052588012013 OxaA-like protein precursor; Validated; Region: PRK02944 1052588012014 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1052588012015 ribonuclease P; Reviewed; Region: rnpA; PRK00499