-- dump date 20140618_225143 -- class Genbank::misc_feature -- table misc_feature_note -- id note 645657000001 Replication protein; Region: Rep_1; pfam01446 645657000002 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 645657000003 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 645657000004 Catalytic site [active] 645657000005 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 645657000006 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645657000007 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 645657000008 DNA binding residues [nucleotide binding] 645657000009 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 645657000010 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 645657000011 DnaA N-terminal domain; Region: DnaA_N; pfam11638 645657000012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657000013 Walker A motif; other site 645657000014 ATP binding site [chemical binding]; other site 645657000015 Walker B motif; other site 645657000016 arginine finger; other site 645657000017 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 645657000018 DnaA box-binding interface [nucleotide binding]; other site 645657000019 DNA polymerase III subunit beta; Validated; Region: PRK05643 645657000020 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 645657000021 putative DNA binding surface [nucleotide binding]; other site 645657000022 dimer interface [polypeptide binding]; other site 645657000023 beta-clamp/clamp loader binding surface; other site 645657000024 beta-clamp/translesion DNA polymerase binding surface; other site 645657000025 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 645657000026 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 645657000027 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 645657000028 Walker A/P-loop; other site 645657000029 ATP binding site [chemical binding]; other site 645657000030 Q-loop/lid; other site 645657000031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657000032 ABC transporter signature motif; other site 645657000033 Walker B; other site 645657000034 D-loop; other site 645657000035 H-loop/switch region; other site 645657000036 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 645657000037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657000038 ATP binding site [chemical binding]; other site 645657000039 Mg2+ binding site [ion binding]; other site 645657000040 G-X-G motif; other site 645657000041 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 645657000042 anchoring element; other site 645657000043 dimer interface [polypeptide binding]; other site 645657000044 ATP binding site [chemical binding]; other site 645657000045 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 645657000046 active site 645657000047 putative metal-binding site [ion binding]; other site 645657000048 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 645657000049 DNA gyrase subunit A; Validated; Region: PRK05560 645657000050 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 645657000051 CAP-like domain; other site 645657000052 active site 645657000053 primary dimer interface [polypeptide binding]; other site 645657000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645657000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645657000056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645657000057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645657000058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645657000059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645657000060 YaaC-like Protein; Region: YaaC; pfam14175 645657000061 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 645657000062 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 645657000063 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 645657000064 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 645657000065 active site 645657000066 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 645657000067 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 645657000068 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 645657000069 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 645657000070 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 645657000071 active site 645657000072 multimer interface [polypeptide binding]; other site 645657000073 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 645657000074 Glutamine amidotransferase class-I; Region: GATase; pfam00117 645657000075 predicted active site [active] 645657000076 catalytic triad [active] 645657000077 seryl-tRNA synthetase; Provisional; Region: PRK05431 645657000078 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 645657000079 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 645657000080 dimer interface [polypeptide binding]; other site 645657000081 active site 645657000082 motif 1; other site 645657000083 motif 2; other site 645657000084 motif 3; other site 645657000085 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 645657000086 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 645657000087 Substrate-binding site [chemical binding]; other site 645657000088 Substrate specificity [chemical binding]; other site 645657000089 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 645657000090 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 645657000091 Substrate-binding site [chemical binding]; other site 645657000092 Substrate specificity [chemical binding]; other site 645657000093 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 645657000094 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657000095 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657000096 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 645657000097 active site 645657000098 Isochorismatase family; Region: Isochorismatase; pfam00857 645657000099 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 645657000100 catalytic triad [active] 645657000101 conserved cis-peptide bond; other site 645657000102 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 645657000103 nucleoside/Zn binding site; other site 645657000104 dimer interface [polypeptide binding]; other site 645657000105 catalytic motif [active] 645657000106 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 645657000107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657000108 Walker A motif; other site 645657000109 ATP binding site [chemical binding]; other site 645657000110 Walker B motif; other site 645657000111 arginine finger; other site 645657000112 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 645657000113 hypothetical protein; Validated; Region: PRK00153 645657000114 recombination protein RecR; Reviewed; Region: recR; PRK00076 645657000115 RecR protein; Region: RecR; pfam02132 645657000116 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 645657000117 putative active site [active] 645657000118 putative metal-binding site [ion binding]; other site 645657000119 tetramer interface [polypeptide binding]; other site 645657000120 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 645657000121 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 645657000122 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 645657000123 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 645657000124 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 645657000125 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 645657000126 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 645657000127 homodimer interface [polypeptide binding]; other site 645657000128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657000129 catalytic residue [active] 645657000130 thymidylate kinase; Validated; Region: tmk; PRK00698 645657000131 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 645657000132 TMP-binding site; other site 645657000133 ATP-binding site [chemical binding]; other site 645657000134 Protein of unknown function (DUF970); Region: DUF970; pfam06153 645657000135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 645657000136 DNA polymerase III subunit delta'; Validated; Region: PRK08058 645657000137 DNA polymerase III subunit delta'; Validated; Region: PRK08485 645657000138 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 645657000139 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 645657000140 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 645657000141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657000142 S-adenosylmethionine binding site [chemical binding]; other site 645657000143 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 645657000144 Predicted methyltransferases [General function prediction only]; Region: COG0313 645657000145 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 645657000146 putative SAM binding site [chemical binding]; other site 645657000147 putative homodimer interface [polypeptide binding]; other site 645657000148 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 645657000149 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 645657000150 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 645657000151 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 645657000152 active site 645657000153 HIGH motif; other site 645657000154 KMSKS motif; other site 645657000155 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 645657000156 tRNA binding surface [nucleotide binding]; other site 645657000157 anticodon binding site; other site 645657000158 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 645657000159 dimer interface [polypeptide binding]; other site 645657000160 putative tRNA-binding site [nucleotide binding]; other site 645657000161 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 645657000162 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 645657000163 active site 645657000164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 645657000165 Domain of unknown function (DUF348); Region: DUF348; pfam03990 645657000166 Domain of unknown function (DUF348); Region: DUF348; pfam03990 645657000167 Domain of unknown function (DUF348); Region: DUF348; pfam03990 645657000168 G5 domain; Region: G5; pfam07501 645657000169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 645657000170 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 645657000171 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 645657000172 putative active site [active] 645657000173 putative metal binding site [ion binding]; other site 645657000174 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 645657000175 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 645657000176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657000177 S-adenosylmethionine binding site [chemical binding]; other site 645657000178 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 645657000179 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 645657000180 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 645657000181 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 645657000182 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 645657000183 pur operon repressor; Provisional; Region: PRK09213 645657000184 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 645657000185 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645657000186 active site 645657000187 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 645657000188 homotrimer interaction site [polypeptide binding]; other site 645657000189 putative active site [active] 645657000190 regulatory protein SpoVG; Reviewed; Region: PRK13259 645657000191 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 645657000192 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 645657000193 Substrate binding site; other site 645657000194 Mg++ binding site; other site 645657000195 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 645657000196 active site 645657000197 substrate binding site [chemical binding]; other site 645657000198 CoA binding site [chemical binding]; other site 645657000199 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 645657000200 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 645657000201 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645657000202 active site 645657000203 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 645657000204 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 645657000205 5S rRNA interface [nucleotide binding]; other site 645657000206 CTC domain interface [polypeptide binding]; other site 645657000207 L16 interface [polypeptide binding]; other site 645657000208 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 645657000209 putative active site [active] 645657000210 catalytic residue [active] 645657000211 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 645657000212 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 645657000213 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 645657000214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645657000215 ATP binding site [chemical binding]; other site 645657000216 putative Mg++ binding site [ion binding]; other site 645657000217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657000218 nucleotide binding region [chemical binding]; other site 645657000219 ATP-binding site [chemical binding]; other site 645657000220 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 645657000221 stage V sporulation protein T; Region: spore_V_T; TIGR02851 645657000222 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 645657000223 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 645657000224 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 645657000225 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 645657000226 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 645657000227 putative SAM binding site [chemical binding]; other site 645657000228 putative homodimer interface [polypeptide binding]; other site 645657000229 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 645657000230 homodimer interface [polypeptide binding]; other site 645657000231 metal binding site [ion binding]; metal-binding site 645657000232 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 645657000233 homodimer interface [polypeptide binding]; other site 645657000234 active site 645657000235 putative chemical substrate binding site [chemical binding]; other site 645657000236 metal binding site [ion binding]; metal-binding site 645657000237 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645657000238 RNA binding surface [nucleotide binding]; other site 645657000239 sporulation protein YabP; Region: spore_yabP; TIGR02892 645657000240 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 645657000241 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 645657000242 Septum formation initiator; Region: DivIC; pfam04977 645657000243 hypothetical protein; Provisional; Region: PRK08582 645657000244 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 645657000245 RNA binding site [nucleotide binding]; other site 645657000246 stage II sporulation protein E; Region: spore_II_E; TIGR02865 645657000247 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 645657000248 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 645657000249 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 645657000250 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 645657000251 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 645657000252 metal ion-dependent adhesion site (MIDAS); other site 645657000253 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 645657000254 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 645657000255 active site 645657000256 ATP binding site [chemical binding]; other site 645657000257 substrate binding site [chemical binding]; other site 645657000258 activation loop (A-loop); other site 645657000259 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 645657000260 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 645657000261 Ligand Binding Site [chemical binding]; other site 645657000262 TilS substrate C-terminal domain; Region: TilS_C; smart00977 645657000263 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645657000264 active site 645657000265 FtsH Extracellular; Region: FtsH_ext; pfam06480 645657000266 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 645657000267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657000268 Walker A motif; other site 645657000269 ATP binding site [chemical binding]; other site 645657000270 Walker B motif; other site 645657000271 arginine finger; other site 645657000272 Peptidase family M41; Region: Peptidase_M41; pfam01434 645657000273 pantothenate kinase; Reviewed; Region: PRK13318 645657000274 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 645657000275 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 645657000276 dimerization interface [polypeptide binding]; other site 645657000277 domain crossover interface; other site 645657000278 redox-dependent activation switch; other site 645657000279 SurA N-terminal domain; Region: SurA_N_3; cl07813 645657000280 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 645657000281 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 645657000282 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 645657000283 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 645657000284 dimer interface [polypeptide binding]; other site 645657000285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657000286 catalytic residue [active] 645657000287 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 645657000288 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 645657000289 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 645657000290 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 645657000291 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 645657000292 glutamine binding [chemical binding]; other site 645657000293 catalytic triad [active] 645657000294 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 645657000295 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 645657000296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657000297 catalytic residue [active] 645657000298 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 645657000299 dihydropteroate synthase; Region: DHPS; TIGR01496 645657000300 substrate binding pocket [chemical binding]; other site 645657000301 dimer interface [polypeptide binding]; other site 645657000302 inhibitor binding site; inhibition site 645657000303 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 645657000304 homooctamer interface [polypeptide binding]; other site 645657000305 active site 645657000306 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 645657000307 catalytic center binding site [active] 645657000308 ATP binding site [chemical binding]; other site 645657000309 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645657000310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657000311 non-specific DNA binding site [nucleotide binding]; other site 645657000312 salt bridge; other site 645657000313 sequence-specific DNA binding site [nucleotide binding]; other site 645657000314 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 645657000315 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 645657000316 FMN binding site [chemical binding]; other site 645657000317 active site 645657000318 catalytic residues [active] 645657000319 substrate binding site [chemical binding]; other site 645657000320 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 645657000321 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 645657000322 dimer interface [polypeptide binding]; other site 645657000323 putative anticodon binding site; other site 645657000324 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 645657000325 motif 1; other site 645657000326 active site 645657000327 motif 2; other site 645657000328 motif 3; other site 645657000329 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 645657000330 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 645657000331 UvrB/uvrC motif; Region: UVR; pfam02151 645657000332 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 645657000333 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 645657000334 ADP binding site [chemical binding]; other site 645657000335 phosphagen binding site; other site 645657000336 substrate specificity loop; other site 645657000337 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 645657000338 Clp amino terminal domain; Region: Clp_N; pfam02861 645657000339 Clp amino terminal domain; Region: Clp_N; pfam02861 645657000340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657000341 Walker A motif; other site 645657000342 ATP binding site [chemical binding]; other site 645657000343 Walker B motif; other site 645657000344 arginine finger; other site 645657000345 UvrB/uvrC motif; Region: UVR; pfam02151 645657000346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657000347 Walker A motif; other site 645657000348 ATP binding site [chemical binding]; other site 645657000349 Walker B motif; other site 645657000350 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 645657000351 DNA repair protein RadA; Provisional; Region: PRK11823 645657000352 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 645657000353 Walker A motif/ATP binding site; other site 645657000354 ATP binding site [chemical binding]; other site 645657000355 Walker B motif; other site 645657000356 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 645657000357 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 645657000358 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 645657000359 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 645657000360 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 645657000361 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 645657000362 putative active site [active] 645657000363 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 645657000364 substrate binding site; other site 645657000365 dimer interface; other site 645657000366 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 645657000367 homotrimer interaction site [polypeptide binding]; other site 645657000368 zinc binding site [ion binding]; other site 645657000369 CDP-binding sites; other site 645657000370 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 645657000371 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 645657000372 active site 645657000373 HIGH motif; other site 645657000374 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 645657000375 active site 645657000376 KMSKS motif; other site 645657000377 serine O-acetyltransferase; Region: cysE; TIGR01172 645657000378 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 645657000379 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 645657000380 trimer interface [polypeptide binding]; other site 645657000381 active site 645657000382 substrate binding site [chemical binding]; other site 645657000383 CoA binding site [chemical binding]; other site 645657000384 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 645657000385 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 645657000386 active site 645657000387 HIGH motif; other site 645657000388 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 645657000389 KMSKS motif; other site 645657000390 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 645657000391 tRNA binding surface [nucleotide binding]; other site 645657000392 anticodon binding site; other site 645657000393 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 645657000394 active site 645657000395 metal binding site [ion binding]; metal-binding site 645657000396 dimerization interface [polypeptide binding]; other site 645657000397 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 645657000398 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 645657000399 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 645657000400 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 645657000401 RNA polymerase factor sigma-70; Validated; Region: PRK08295 645657000402 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657000403 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 645657000404 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 645657000405 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 645657000406 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 645657000407 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 645657000408 putative homodimer interface [polypeptide binding]; other site 645657000409 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 645657000410 heterodimer interface [polypeptide binding]; other site 645657000411 homodimer interface [polypeptide binding]; other site 645657000412 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 645657000413 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 645657000414 23S rRNA interface [nucleotide binding]; other site 645657000415 L7/L12 interface [polypeptide binding]; other site 645657000416 putative thiostrepton binding site; other site 645657000417 L25 interface [polypeptide binding]; other site 645657000418 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 645657000419 mRNA/rRNA interface [nucleotide binding]; other site 645657000420 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 645657000421 23S rRNA interface [nucleotide binding]; other site 645657000422 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 645657000423 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 645657000424 core dimer interface [polypeptide binding]; other site 645657000425 peripheral dimer interface [polypeptide binding]; other site 645657000426 L10 interface [polypeptide binding]; other site 645657000427 L11 interface [polypeptide binding]; other site 645657000428 putative EF-Tu interaction site [polypeptide binding]; other site 645657000429 putative EF-G interaction site [polypeptide binding]; other site 645657000430 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 645657000431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657000432 S-adenosylmethionine binding site [chemical binding]; other site 645657000433 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 645657000434 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 645657000435 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 645657000436 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 645657000437 RPB1 interaction site [polypeptide binding]; other site 645657000438 RPB10 interaction site [polypeptide binding]; other site 645657000439 RPB11 interaction site [polypeptide binding]; other site 645657000440 RPB3 interaction site [polypeptide binding]; other site 645657000441 RPB12 interaction site [polypeptide binding]; other site 645657000442 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 645657000443 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 645657000444 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 645657000445 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 645657000446 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 645657000447 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 645657000448 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 645657000449 G-loop; other site 645657000450 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 645657000451 DNA binding site [nucleotide binding] 645657000452 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 645657000453 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 645657000454 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 645657000455 S17 interaction site [polypeptide binding]; other site 645657000456 S8 interaction site; other site 645657000457 16S rRNA interaction site [nucleotide binding]; other site 645657000458 streptomycin interaction site [chemical binding]; other site 645657000459 23S rRNA interaction site [nucleotide binding]; other site 645657000460 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 645657000461 30S ribosomal protein S7; Validated; Region: PRK05302 645657000462 elongation factor G; Reviewed; Region: PRK00007 645657000463 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 645657000464 Switch I region; other site 645657000465 G2 box; other site 645657000466 putative GEF interaction site [polypeptide binding]; other site 645657000467 G3 box; other site 645657000468 Switch II region; other site 645657000469 GTP/Mg2+ binding site [chemical binding]; other site 645657000470 G4 box; other site 645657000471 G5 box; other site 645657000472 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 645657000473 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 645657000474 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 645657000475 elongation factor Tu; Reviewed; Region: PRK00049 645657000476 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 645657000477 G1 box; other site 645657000478 GEF interaction site [polypeptide binding]; other site 645657000479 GTP/Mg2+ binding site [chemical binding]; other site 645657000480 Switch I region; other site 645657000481 G2 box; other site 645657000482 G3 box; other site 645657000483 Switch II region; other site 645657000484 G4 box; other site 645657000485 G5 box; other site 645657000486 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 645657000487 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 645657000488 Antibiotic Binding Site [chemical binding]; other site 645657000489 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 645657000490 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 645657000491 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 645657000492 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 645657000493 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 645657000494 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 645657000495 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 645657000496 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 645657000497 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 645657000498 putative translocon binding site; other site 645657000499 protein-rRNA interface [nucleotide binding]; other site 645657000500 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 645657000501 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 645657000502 G-X-X-G motif; other site 645657000503 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 645657000504 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 645657000505 23S rRNA interface [nucleotide binding]; other site 645657000506 5S rRNA interface [nucleotide binding]; other site 645657000507 putative antibiotic binding site [chemical binding]; other site 645657000508 L25 interface [polypeptide binding]; other site 645657000509 L27 interface [polypeptide binding]; other site 645657000510 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 645657000511 23S rRNA interface [nucleotide binding]; other site 645657000512 putative translocon interaction site; other site 645657000513 signal recognition particle (SRP54) interaction site; other site 645657000514 L23 interface [polypeptide binding]; other site 645657000515 trigger factor interaction site; other site 645657000516 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 645657000517 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 645657000518 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 645657000519 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 645657000520 RNA binding site [nucleotide binding]; other site 645657000521 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 645657000522 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 645657000523 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 645657000524 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 645657000525 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 645657000526 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 645657000527 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 645657000528 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 645657000529 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 645657000530 5S rRNA interface [nucleotide binding]; other site 645657000531 L27 interface [polypeptide binding]; other site 645657000532 23S rRNA interface [nucleotide binding]; other site 645657000533 L5 interface [polypeptide binding]; other site 645657000534 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 645657000535 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 645657000536 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 645657000537 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 645657000538 23S rRNA binding site [nucleotide binding]; other site 645657000539 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 645657000540 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 645657000541 SecY translocase; Region: SecY; pfam00344 645657000542 adenylate kinase; Reviewed; Region: adk; PRK00279 645657000543 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 645657000544 AMP-binding site [chemical binding]; other site 645657000545 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 645657000546 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 645657000547 active site 645657000548 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 645657000549 RNA binding site [nucleotide binding]; other site 645657000550 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 645657000551 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 645657000552 30S ribosomal protein S13; Region: bact_S13; TIGR03631 645657000553 30S ribosomal protein S11; Validated; Region: PRK05309 645657000554 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 645657000555 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 645657000556 alphaNTD homodimer interface [polypeptide binding]; other site 645657000557 alphaNTD - beta interaction site [polypeptide binding]; other site 645657000558 alphaNTD - beta' interaction site [polypeptide binding]; other site 645657000559 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 645657000560 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 645657000561 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 645657000562 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 645657000563 Walker A/P-loop; other site 645657000564 ATP binding site [chemical binding]; other site 645657000565 Q-loop/lid; other site 645657000566 ABC transporter signature motif; other site 645657000567 Walker B; other site 645657000568 D-loop; other site 645657000569 H-loop/switch region; other site 645657000570 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 645657000571 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 645657000572 Walker A/P-loop; other site 645657000573 ATP binding site [chemical binding]; other site 645657000574 Q-loop/lid; other site 645657000575 ABC transporter signature motif; other site 645657000576 Walker B; other site 645657000577 D-loop; other site 645657000578 H-loop/switch region; other site 645657000579 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 645657000580 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 645657000581 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 645657000582 dimerization interface 3.5A [polypeptide binding]; other site 645657000583 active site 645657000584 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 645657000585 23S rRNA interface [nucleotide binding]; other site 645657000586 L3 interface [polypeptide binding]; other site 645657000587 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 645657000588 Methyltransferase domain; Region: Methyltransf_31; pfam13847 645657000589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657000590 S-adenosylmethionine binding site [chemical binding]; other site 645657000591 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 645657000592 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 645657000593 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645657000594 active site 645657000595 metal binding site [ion binding]; metal-binding site 645657000596 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 645657000597 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 645657000598 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 645657000599 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 645657000600 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 645657000601 NodB motif; other site 645657000602 putative active site [active] 645657000603 putative catalytic site [active] 645657000604 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 645657000605 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 645657000606 Sulfate transporter family; Region: Sulfate_transp; pfam00916 645657000607 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 645657000608 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 645657000609 Sodium Bile acid symporter family; Region: SBF; cl17470 645657000610 Putative esterase; Region: Esterase; pfam00756 645657000611 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 645657000612 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 645657000613 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645657000614 dimer interface [polypeptide binding]; other site 645657000615 putative PBP binding regions; other site 645657000616 ABC-ATPase subunit interface; other site 645657000617 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 645657000618 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 645657000619 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645657000620 ABC-ATPase subunit interface; other site 645657000621 dimer interface [polypeptide binding]; other site 645657000622 putative PBP binding regions; other site 645657000623 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 645657000624 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 645657000625 putative ligand binding residues [chemical binding]; other site 645657000626 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645657000627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657000628 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 645657000629 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 645657000630 putative ligand binding residues [chemical binding]; other site 645657000631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 645657000632 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 645657000633 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 645657000634 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 645657000635 putative periplasmic esterase; Provisional; Region: PRK03642 645657000636 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 645657000637 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 645657000638 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645657000639 active site turn [active] 645657000640 phosphorylation site [posttranslational modification] 645657000641 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645657000642 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 645657000643 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 645657000644 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 645657000645 putative active site [active] 645657000646 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 645657000647 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 645657000648 putative active site [active] 645657000649 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 645657000650 Uncharacterized conserved protein [Function unknown]; Region: COG1683 645657000651 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 645657000652 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657000653 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657000654 DNA binding residues [nucleotide binding] 645657000655 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 645657000656 Putative zinc-finger; Region: zf-HC2; pfam13490 645657000657 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 645657000658 Uncharacterized conserved protein [Function unknown]; Region: COG1624 645657000659 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 645657000660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 645657000661 YbbR-like protein; Region: YbbR; pfam07949 645657000662 YbbR-like protein; Region: YbbR; pfam07949 645657000663 YbbR-like protein; Region: YbbR; pfam07949 645657000664 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 645657000665 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 645657000666 active site 645657000667 substrate binding site [chemical binding]; other site 645657000668 metal binding site [ion binding]; metal-binding site 645657000669 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 645657000670 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 645657000671 glutaminase active site [active] 645657000672 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 645657000673 dimer interface [polypeptide binding]; other site 645657000674 active site 645657000675 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 645657000676 dimer interface [polypeptide binding]; other site 645657000677 active site 645657000678 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 645657000679 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 645657000680 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 645657000681 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 645657000682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657000683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657000684 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 645657000685 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 645657000686 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 645657000687 DNA binding site [nucleotide binding] 645657000688 active site 645657000689 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 645657000690 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 645657000691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 645657000692 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 645657000693 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 645657000694 zinc binding site [ion binding]; other site 645657000695 Uncharacterized conserved protein [Function unknown]; Region: COG5609 645657000696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645657000697 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645657000698 DNA binding site [nucleotide binding] 645657000699 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645657000700 HAMP domain; Region: HAMP; pfam00672 645657000701 dimerization interface [polypeptide binding]; other site 645657000702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657000703 dimer interface [polypeptide binding]; other site 645657000704 phosphorylation site [posttranslational modification] 645657000705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657000706 ATP binding site [chemical binding]; other site 645657000707 Mg2+ binding site [ion binding]; other site 645657000708 G-X-G motif; other site 645657000709 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 645657000710 active site 645657000711 ATP binding site [chemical binding]; other site 645657000712 substrate binding site [chemical binding]; other site 645657000713 activation loop (A-loop); other site 645657000714 putative transport protein YifK; Provisional; Region: PRK10746 645657000715 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 645657000716 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 645657000717 Cytochrome P450; Region: p450; cl12078 645657000718 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 645657000719 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 645657000720 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 645657000721 active site 645657000722 catalytic site [active] 645657000723 metal binding site [ion binding]; metal-binding site 645657000724 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 645657000725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657000726 putative substrate translocation pore; other site 645657000727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657000728 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 645657000729 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657000730 MarR family; Region: MarR; pfam01047 645657000731 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 645657000732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657000733 Coenzyme A binding pocket [chemical binding]; other site 645657000734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657000735 putative substrate translocation pore; other site 645657000736 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657000737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 645657000738 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 645657000739 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 645657000740 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 645657000741 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 645657000742 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 645657000743 active site 645657000744 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 645657000745 EamA-like transporter family; Region: EamA; pfam00892 645657000746 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 645657000747 EamA-like transporter family; Region: EamA; pfam00892 645657000748 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 645657000749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657000750 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645657000751 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657000752 Phage lysis protein, holin; Region: Phage_holin; pfam04688 645657000753 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657000754 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 645657000755 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657000756 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 645657000757 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657000758 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 645657000759 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657000760 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657000761 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 645657000762 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657000763 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 645657000764 catalytic residue [active] 645657000765 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 645657000766 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 645657000767 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645657000768 ATP-grasp domain; Region: ATP-grasp; pfam02222 645657000769 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 645657000770 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 645657000771 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 645657000772 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 645657000773 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 645657000774 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 645657000775 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 645657000776 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 645657000777 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 645657000778 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645657000779 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657000780 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 645657000781 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 645657000782 active site residue [active] 645657000783 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 645657000784 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 645657000785 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 645657000786 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645657000787 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 645657000788 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645657000789 active site turn [active] 645657000790 phosphorylation site [posttranslational modification] 645657000791 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 645657000792 HPr interaction site; other site 645657000793 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645657000794 active site 645657000795 phosphorylation site [posttranslational modification] 645657000796 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 645657000797 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 645657000798 active site 645657000799 trimer interface [polypeptide binding]; other site 645657000800 allosteric site; other site 645657000801 active site lid [active] 645657000802 hexamer (dimer of trimers) interface [polypeptide binding]; other site 645657000803 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 645657000804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657000805 DNA-binding site [nucleotide binding]; DNA binding site 645657000806 UTRA domain; Region: UTRA; pfam07702 645657000807 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 645657000808 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 645657000809 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 645657000810 homodimer interface [polypeptide binding]; other site 645657000811 substrate-cofactor binding pocket; other site 645657000812 catalytic residue [active] 645657000813 S-methylmethionine transporter; Provisional; Region: PRK11387 645657000814 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 645657000815 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 645657000816 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 645657000817 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 645657000818 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 645657000819 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 645657000820 glutaminase; Reviewed; Region: PRK12357 645657000821 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 645657000822 Chorismate mutase type II; Region: CM_2; cl00693 645657000823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645657000824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657000825 ATP binding site [chemical binding]; other site 645657000826 Mg2+ binding site [ion binding]; other site 645657000827 G-X-G motif; other site 645657000828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657000829 Response regulator receiver domain; Region: Response_reg; pfam00072 645657000830 active site 645657000831 phosphorylation site [posttranslational modification] 645657000832 intermolecular recognition site; other site 645657000833 dimerization interface [polypeptide binding]; other site 645657000834 YcbB domain; Region: YcbB; pfam08664 645657000835 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 645657000836 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 645657000837 putative active site [active] 645657000838 catalytic residue [active] 645657000839 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 645657000840 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 645657000841 NAD(P) binding site [chemical binding]; other site 645657000842 catalytic residues [active] 645657000843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657000844 D-galactonate transporter; Region: 2A0114; TIGR00893 645657000845 putative substrate translocation pore; other site 645657000846 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 645657000847 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 645657000848 active site 645657000849 tetramer interface [polypeptide binding]; other site 645657000850 Transcriptional regulators [Transcription]; Region: FadR; COG2186 645657000851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657000852 DNA-binding site [nucleotide binding]; DNA binding site 645657000853 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 645657000854 galactarate dehydratase; Region: galactar-dH20; TIGR03248 645657000855 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 645657000856 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 645657000857 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 645657000858 putative active site [active] 645657000859 putative substrate binding site [chemical binding]; other site 645657000860 Phosphotransferase enzyme family; Region: APH; pfam01636 645657000861 ATP binding site [chemical binding]; other site 645657000862 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 645657000863 dodecamer interface 1 [polypeptide binding]; other site 645657000864 dodecamer interface 2 [polypeptide binding]; other site 645657000865 trimer interface [polypeptide binding]; other site 645657000866 TRAP binding interface [polypeptide binding]; other site 645657000867 Zn binding site [ion binding]; other site 645657000868 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 645657000869 EamA-like transporter family; Region: EamA; pfam00892 645657000870 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645657000871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657000872 active site 645657000873 phosphorylation site [posttranslational modification] 645657000874 intermolecular recognition site; other site 645657000875 dimerization interface [polypeptide binding]; other site 645657000876 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645657000877 DNA binding site [nucleotide binding] 645657000878 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645657000879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657000880 dimer interface [polypeptide binding]; other site 645657000881 phosphorylation site [posttranslational modification] 645657000882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657000883 ATP binding site [chemical binding]; other site 645657000884 Mg2+ binding site [ion binding]; other site 645657000885 G-X-G motif; other site 645657000886 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645657000887 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 645657000888 Walker A/P-loop; other site 645657000889 ATP binding site [chemical binding]; other site 645657000890 Q-loop/lid; other site 645657000891 ABC transporter signature motif; other site 645657000892 Walker B; other site 645657000893 D-loop; other site 645657000894 H-loop/switch region; other site 645657000895 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 645657000896 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645657000897 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 645657000898 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 645657000899 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 645657000900 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 645657000901 metal ion-dependent adhesion site (MIDAS); other site 645657000902 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 645657000903 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 645657000904 putative active site [active] 645657000905 putative metal binding site [ion binding]; other site 645657000906 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 645657000907 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 645657000908 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 645657000909 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 645657000910 putative substrate binding pocket [chemical binding]; other site 645657000911 AC domain interface; other site 645657000912 catalytic triad [active] 645657000913 AB domain interface; other site 645657000914 interchain disulfide; other site 645657000915 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 645657000916 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 645657000917 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645657000918 catalytic residue [active] 645657000919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657000920 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657000921 putative substrate translocation pore; other site 645657000922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657000923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657000924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657000925 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 645657000926 active site 645657000927 homotetramer interface [polypeptide binding]; other site 645657000928 homodimer interface [polypeptide binding]; other site 645657000929 Lipase (class 2); Region: Lipase_2; pfam01674 645657000930 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 645657000931 Predicted membrane protein/domain [Function unknown]; Region: COG1714 645657000932 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 645657000933 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 645657000934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657000935 ATP binding site [chemical binding]; other site 645657000936 Mg2+ binding site [ion binding]; other site 645657000937 G-X-G motif; other site 645657000938 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 645657000939 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 645657000940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657000941 active site 645657000942 phosphorylation site [posttranslational modification] 645657000943 intermolecular recognition site; other site 645657000944 dimerization interface [polypeptide binding]; other site 645657000945 LytTr DNA-binding domain; Region: LytTR; pfam04397 645657000946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657000947 Walker A/P-loop; other site 645657000948 ATP binding site [chemical binding]; other site 645657000949 Q-loop/lid; other site 645657000950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657000951 ABC transporter signature motif; other site 645657000952 Walker B; other site 645657000953 D-loop; other site 645657000954 H-loop/switch region; other site 645657000955 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 645657000956 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 645657000957 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645657000958 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645657000959 active site 645657000960 catalytic tetrad [active] 645657000961 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 645657000962 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 645657000963 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 645657000964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 645657000965 binding surface 645657000966 TPR motif; other site 645657000967 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657000968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657000969 binding surface 645657000970 TPR motif; other site 645657000971 glucose-1-dehydrogenase; Provisional; Region: PRK08936 645657000972 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 645657000973 NAD binding site [chemical binding]; other site 645657000974 homodimer interface [polypeptide binding]; other site 645657000975 active site 645657000976 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 645657000977 active site 645657000978 catalytic site [active] 645657000979 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 645657000980 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 645657000981 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 645657000982 metal binding site [ion binding]; metal-binding site 645657000983 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 645657000984 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 645657000985 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 645657000986 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645657000987 ABC-ATPase subunit interface; other site 645657000988 dimer interface [polypeptide binding]; other site 645657000989 putative PBP binding regions; other site 645657000990 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 645657000991 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 645657000992 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 645657000993 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 645657000994 putative metal binding site [ion binding]; other site 645657000995 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 645657000996 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 645657000997 putative metal binding site [ion binding]; other site 645657000998 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 645657000999 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 645657001000 putative metal binding site [ion binding]; other site 645657001001 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 645657001002 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 645657001003 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 645657001004 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 645657001005 Homeodomain-like domain; Region: HTH_23; pfam13384 645657001006 putative transposase OrfB; Reviewed; Region: PHA02517 645657001007 HTH-like domain; Region: HTH_21; pfam13276 645657001008 Integrase core domain; Region: rve; pfam00665 645657001009 Integrase core domain; Region: rve_3; pfam13683 645657001010 benzoate transport; Region: 2A0115; TIGR00895 645657001011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657001012 putative substrate translocation pore; other site 645657001013 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 645657001014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657001015 putative substrate translocation pore; other site 645657001016 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657001017 dimerization interface [polypeptide binding]; other site 645657001018 putative DNA binding site [nucleotide binding]; other site 645657001019 putative Zn2+ binding site [ion binding]; other site 645657001020 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 645657001021 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 645657001022 Walker A/P-loop; other site 645657001023 ATP binding site [chemical binding]; other site 645657001024 Q-loop/lid; other site 645657001025 ABC transporter signature motif; other site 645657001026 Walker B; other site 645657001027 D-loop; other site 645657001028 H-loop/switch region; other site 645657001029 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 645657001030 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 645657001031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657001032 dimer interface [polypeptide binding]; other site 645657001033 conserved gate region; other site 645657001034 putative PBP binding loops; other site 645657001035 ABC-ATPase subunit interface; other site 645657001036 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 645657001037 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 645657001038 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 645657001039 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 645657001040 amidohydrolase; Region: amidohydrolases; TIGR01891 645657001041 metal binding site [ion binding]; metal-binding site 645657001042 putative dimer interface [polypeptide binding]; other site 645657001043 Predicted membrane protein [Function unknown]; Region: COG1288 645657001044 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 645657001045 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 645657001046 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 645657001047 active site 645657001048 Ca binding site [ion binding]; other site 645657001049 catalytic site [active] 645657001050 Aamy_C domain; Region: Aamy_C; smart00632 645657001051 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 645657001052 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 645657001053 tetramer (dimer of dimers) interface [polypeptide binding]; other site 645657001054 NAD binding site [chemical binding]; other site 645657001055 dimer interface [polypeptide binding]; other site 645657001056 substrate binding site [chemical binding]; other site 645657001057 L-lactate permease; Region: Lactate_perm; cl00701 645657001058 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 645657001059 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 645657001060 L-lactate permease; Region: Lactate_perm; cl00701 645657001061 Uncharacterized conserved protein [Function unknown]; Region: COG3403 645657001062 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 645657001063 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 645657001064 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 645657001065 NAD+ synthetase; Region: nadE; TIGR00552 645657001066 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 645657001067 homodimer interface [polypeptide binding]; other site 645657001068 NAD binding pocket [chemical binding]; other site 645657001069 ATP binding pocket [chemical binding]; other site 645657001070 Mg binding site [ion binding]; other site 645657001071 active-site loop [active] 645657001072 AAA domain; Region: AAA_18; pfam13238 645657001073 shikimate kinase; Reviewed; Region: aroK; PRK00131 645657001074 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 645657001075 ADP binding site [chemical binding]; other site 645657001076 magnesium binding site [ion binding]; other site 645657001077 putative shikimate binding site; other site 645657001078 putative transposase OrfB; Reviewed; Region: PHA02517 645657001079 HTH-like domain; Region: HTH_21; pfam13276 645657001080 Integrase core domain; Region: rve; pfam00665 645657001081 Integrase core domain; Region: rve_2; pfam13333 645657001082 Transposase; Region: HTH_Tnp_1; pfam01527 645657001083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 645657001084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657001085 S-adenosylmethionine binding site [chemical binding]; other site 645657001086 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657001087 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657001088 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 645657001089 dimerization interface [polypeptide binding]; other site 645657001090 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 645657001091 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 645657001092 Proline dehydrogenase; Region: Pro_dh; pfam01619 645657001093 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 645657001094 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 645657001095 Glutamate binding site [chemical binding]; other site 645657001096 homodimer interface [polypeptide binding]; other site 645657001097 NAD binding site [chemical binding]; other site 645657001098 catalytic residues [active] 645657001099 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 645657001100 Na binding site [ion binding]; other site 645657001101 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 645657001102 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 645657001103 Predicted membrane protein [Function unknown]; Region: COG3689 645657001104 Predicted permeases [General function prediction only]; Region: COG0701 645657001105 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 645657001106 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 645657001107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645657001108 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645657001109 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 645657001110 active site 645657001111 SAM binding site [chemical binding]; other site 645657001112 homodimer interface [polypeptide binding]; other site 645657001113 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 645657001114 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 645657001115 active site 645657001116 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 645657001117 [2Fe-2S] cluster binding site [ion binding]; other site 645657001118 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 645657001119 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645657001120 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 645657001121 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 645657001122 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 645657001123 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 645657001124 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 645657001125 [4Fe-4S] binding site [ion binding]; other site 645657001126 molybdopterin cofactor binding site; other site 645657001127 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 645657001128 molybdopterin cofactor binding site; other site 645657001129 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 645657001130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645657001131 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 645657001132 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 645657001133 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 645657001134 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 645657001135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657001136 putative substrate translocation pore; other site 645657001137 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 645657001138 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 645657001139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 645657001140 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 645657001141 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 645657001142 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 645657001143 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 645657001144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657001145 dimer interface [polypeptide binding]; other site 645657001146 conserved gate region; other site 645657001147 putative PBP binding loops; other site 645657001148 ABC-ATPase subunit interface; other site 645657001149 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645657001150 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645657001151 substrate binding pocket [chemical binding]; other site 645657001152 membrane-bound complex binding site; other site 645657001153 hinge residues; other site 645657001154 RDD family; Region: RDD; pfam06271 645657001155 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 645657001156 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657001157 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657001158 putative DNA binding site [nucleotide binding]; other site 645657001159 putative Zn2+ binding site [ion binding]; other site 645657001160 hypothetical protein; Provisional; Region: PRK09272 645657001161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657001162 Walker A/P-loop; other site 645657001163 ATP binding site [chemical binding]; other site 645657001164 Q-loop/lid; other site 645657001165 ABC transporter signature motif; other site 645657001166 Walker B; other site 645657001167 D-loop; other site 645657001168 Predicted ATPase [General function prediction only]; Region: COG3910 645657001169 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 645657001170 beta-galactosidase; Region: BGL; TIGR03356 645657001171 Competence protein J (ComJ); Region: ComJ; pfam11033 645657001172 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 645657001173 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 645657001174 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 645657001175 dimer interface [polypeptide binding]; other site 645657001176 putative CheW interface [polypeptide binding]; other site 645657001177 Domain of unknown function (DUF4042); Region: DUF4042; pfam13251 645657001178 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645657001179 dimerization interface [polypeptide binding]; other site 645657001180 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 645657001181 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 645657001182 tetramer interface [polypeptide binding]; other site 645657001183 active site 645657001184 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 645657001185 active site 645657001186 dimer interface [polypeptide binding]; other site 645657001187 magnesium binding site [ion binding]; other site 645657001188 Predicted transcriptional regulators [Transcription]; Region: COG1733 645657001189 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 645657001190 from glimmer orf00513 and orf00515; surfactin synthetase 645657001191 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645657001192 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 645657001193 Condensation domain; Region: Condensation; pfam00668 645657001194 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 645657001195 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 645657001196 from glimmer orf00516 and orf00518; surfactin synthetase 645657001197 Condensation domain; Region: Condensation; pfam00668 645657001198 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 645657001199 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 645657001200 acyl-activating enzyme (AAE) consensus motif; other site 645657001201 AMP binding site [chemical binding]; other site 645657001202 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 645657001203 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 645657001204 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 645657001205 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 645657001206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657001207 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657001208 putative substrate translocation pore; other site 645657001209 YcxB-like protein; Region: YcxB; pfam14317 645657001210 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 645657001211 EamA-like transporter family; Region: EamA; pfam00892 645657001212 EamA-like transporter family; Region: EamA; pfam00892 645657001213 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 645657001214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657001215 DNA-binding site [nucleotide binding]; DNA binding site 645657001216 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657001217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657001218 homodimer interface [polypeptide binding]; other site 645657001219 catalytic residue [active] 645657001220 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 645657001221 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 645657001222 Predicted membrane protein [Function unknown]; Region: COG2364 645657001223 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645657001224 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 645657001225 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 645657001226 Walker A/P-loop; other site 645657001227 ATP binding site [chemical binding]; other site 645657001228 Q-loop/lid; other site 645657001229 ABC transporter signature motif; other site 645657001230 Walker B; other site 645657001231 D-loop; other site 645657001232 H-loop/switch region; other site 645657001233 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 645657001234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657001235 dimer interface [polypeptide binding]; other site 645657001236 conserved gate region; other site 645657001237 putative PBP binding loops; other site 645657001238 ABC-ATPase subunit interface; other site 645657001239 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645657001240 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645657001241 substrate binding pocket [chemical binding]; other site 645657001242 membrane-bound complex binding site; other site 645657001243 hinge residues; other site 645657001244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657001245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657001246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 645657001247 dimerization interface [polypeptide binding]; other site 645657001248 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 645657001249 Flavoprotein; Region: Flavoprotein; pfam02441 645657001250 UbiD family decarboxylase; Region: TIGR00148 645657001251 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 645657001252 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 645657001253 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 645657001254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657001255 putative substrate translocation pore; other site 645657001256 POT family; Region: PTR2; pfam00854 645657001257 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 645657001258 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 645657001259 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 645657001260 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 645657001261 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 645657001262 Spore germination protein; Region: Spore_permease; pfam03845 645657001263 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645657001264 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645657001265 Walker A/P-loop; other site 645657001266 ATP binding site [chemical binding]; other site 645657001267 Q-loop/lid; other site 645657001268 ABC transporter signature motif; other site 645657001269 Walker B; other site 645657001270 D-loop; other site 645657001271 H-loop/switch region; other site 645657001272 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645657001273 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645657001274 FtsX-like permease family; Region: FtsX; pfam02687 645657001275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645657001276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657001277 active site 645657001278 phosphorylation site [posttranslational modification] 645657001279 intermolecular recognition site; other site 645657001280 dimerization interface [polypeptide binding]; other site 645657001281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645657001282 DNA binding site [nucleotide binding] 645657001283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645657001284 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645657001285 dimerization interface [polypeptide binding]; other site 645657001286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657001287 dimer interface [polypeptide binding]; other site 645657001288 phosphorylation site [posttranslational modification] 645657001289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657001290 ATP binding site [chemical binding]; other site 645657001291 Mg2+ binding site [ion binding]; other site 645657001292 G-X-G motif; other site 645657001293 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657001294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657001295 TPR motif; other site 645657001296 binding surface 645657001297 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657001298 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 645657001299 aspartate kinase; Reviewed; Region: PRK09034 645657001300 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 645657001301 putative catalytic residues [active] 645657001302 putative nucleotide binding site [chemical binding]; other site 645657001303 putative aspartate binding site [chemical binding]; other site 645657001304 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 645657001305 allosteric regulatory residue; other site 645657001306 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 645657001307 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 645657001308 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645657001309 ABC-ATPase subunit interface; other site 645657001310 dimer interface [polypeptide binding]; other site 645657001311 putative PBP binding regions; other site 645657001312 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 645657001313 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645657001314 ABC-ATPase subunit interface; other site 645657001315 dimer interface [polypeptide binding]; other site 645657001316 putative PBP binding regions; other site 645657001317 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 645657001318 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 645657001319 Walker A/P-loop; other site 645657001320 ATP binding site [chemical binding]; other site 645657001321 Q-loop/lid; other site 645657001322 ABC transporter signature motif; other site 645657001323 Walker B; other site 645657001324 D-loop; other site 645657001325 H-loop/switch region; other site 645657001326 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 645657001327 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 645657001328 putative ligand binding residues [chemical binding]; other site 645657001329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657001330 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657001331 putative substrate translocation pore; other site 645657001332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657001333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657001334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657001335 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 645657001336 dimer interface [polypeptide binding]; other site 645657001337 FMN binding site [chemical binding]; other site 645657001338 NADPH bind site [chemical binding]; other site 645657001339 Uncharacterized conserved protein [Function unknown]; Region: COG1359 645657001340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657001341 dimerization interface [polypeptide binding]; other site 645657001342 putative DNA binding site [nucleotide binding]; other site 645657001343 putative Zn2+ binding site [ion binding]; other site 645657001344 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 645657001345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657001346 DNA-binding site [nucleotide binding]; DNA binding site 645657001347 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657001348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657001349 homodimer interface [polypeptide binding]; other site 645657001350 catalytic residue [active] 645657001351 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 645657001352 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645657001353 inhibitor-cofactor binding pocket; inhibition site 645657001354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657001355 catalytic residue [active] 645657001356 succinic semialdehyde dehydrogenase; Region: PLN02278 645657001357 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 645657001358 tetramerization interface [polypeptide binding]; other site 645657001359 NAD(P) binding site [chemical binding]; other site 645657001360 catalytic residues [active] 645657001361 Sugar transport protein; Region: Sugar_transport; pfam06800 645657001362 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 645657001363 glucose-1-dehydrogenase; Provisional; Region: PRK08936 645657001364 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 645657001365 NAD binding site [chemical binding]; other site 645657001366 homodimer interface [polypeptide binding]; other site 645657001367 active site 645657001368 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 645657001369 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 645657001370 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 645657001371 YtkA-like; Region: YtkA; pfam13115 645657001372 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 645657001373 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 645657001374 NosL; Region: NosL; cl01769 645657001375 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 645657001376 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 645657001377 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 645657001378 active site 645657001379 P-loop; other site 645657001380 phosphorylation site [posttranslational modification] 645657001381 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645657001382 active site 645657001383 phosphorylation site [posttranslational modification] 645657001384 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 645657001385 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 645657001386 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 645657001387 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 645657001388 tartrate dehydrogenase; Provisional; Region: PRK08194 645657001389 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 645657001390 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 645657001391 Catalytic site [active] 645657001392 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 645657001393 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 645657001394 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 645657001395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657001396 active site 645657001397 motif I; other site 645657001398 motif II; other site 645657001399 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657001400 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 645657001401 putative active site [active] 645657001402 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 645657001403 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 645657001404 hypothetical protein; Provisional; Region: PRK05463 645657001405 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 645657001406 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 645657001407 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 645657001408 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 645657001409 Transcriptional regulator [Transcription]; Region: IclR; COG1414 645657001410 Bacterial transcriptional regulator; Region: IclR; pfam01614 645657001411 Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755 645657001412 active site 645657001413 catalytic triad [active] 645657001414 oxyanion hole [active] 645657001415 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 645657001416 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 645657001417 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 645657001418 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 645657001419 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 645657001420 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645657001421 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645657001422 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645657001423 active site 645657001424 catalytic tetrad [active] 645657001425 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645657001426 HTH domain; Region: HTH_11; pfam08279 645657001427 PRD domain; Region: PRD; pfam00874 645657001428 PRD domain; Region: PRD; pfam00874 645657001429 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645657001430 active site 645657001431 P-loop; other site 645657001432 phosphorylation site [posttranslational modification] 645657001433 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 645657001434 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 645657001435 acyl-activating enzyme (AAE) consensus motif; other site 645657001436 putative AMP binding site [chemical binding]; other site 645657001437 putative active site [active] 645657001438 putative CoA binding site [chemical binding]; other site 645657001439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657001440 S-adenosylmethionine binding site [chemical binding]; other site 645657001441 short chain dehydrogenase; Provisional; Region: PRK06701 645657001442 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 645657001443 NAD binding site [chemical binding]; other site 645657001444 metal binding site [ion binding]; metal-binding site 645657001445 active site 645657001446 ABC-type sugar transport system, auxiliary component [General function prediction only]; Region: COG3822 645657001447 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 645657001448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645657001449 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 645657001450 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 645657001451 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 645657001452 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 645657001453 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 645657001454 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 645657001455 putative DNA binding site [nucleotide binding]; other site 645657001456 putative Zn2+ binding site [ion binding]; other site 645657001457 AsnC family; Region: AsnC_trans_reg; pfam01037 645657001458 DNA topoisomerase III; Provisional; Region: PRK07726 645657001459 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 645657001460 active site 645657001461 putative interdomain interaction site [polypeptide binding]; other site 645657001462 putative metal-binding site [ion binding]; other site 645657001463 putative nucleotide binding site [chemical binding]; other site 645657001464 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 645657001465 domain I; other site 645657001466 DNA binding groove [nucleotide binding] 645657001467 phosphate binding site [ion binding]; other site 645657001468 domain II; other site 645657001469 domain III; other site 645657001470 nucleotide binding site [chemical binding]; other site 645657001471 catalytic site [active] 645657001472 domain IV; other site 645657001473 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 645657001474 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 645657001475 nudix motif; other site 645657001476 pyruvate oxidase; Provisional; Region: PRK08611 645657001477 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 645657001478 PYR/PP interface [polypeptide binding]; other site 645657001479 tetramer interface [polypeptide binding]; other site 645657001480 dimer interface [polypeptide binding]; other site 645657001481 TPP binding site [chemical binding]; other site 645657001482 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 645657001483 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 645657001484 TPP-binding site [chemical binding]; other site 645657001485 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 645657001486 manganese transport protein MntH; Reviewed; Region: PRK00701 645657001487 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 645657001488 Predicted membrane protein [Function unknown]; Region: COG2261 645657001489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 645657001490 EcsC protein family; Region: EcsC; pfam12787 645657001491 General stress protein [General function prediction only]; Region: GsiB; COG3729 645657001492 General stress protein [General function prediction only]; Region: GsiB; COG3729 645657001493 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 645657001494 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 645657001495 dimanganese center [ion binding]; other site 645657001496 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 645657001497 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 645657001498 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 645657001499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657001500 putative active site [active] 645657001501 heme pocket [chemical binding]; other site 645657001502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657001503 ATP binding site [chemical binding]; other site 645657001504 Mg2+ binding site [ion binding]; other site 645657001505 G-X-G motif; other site 645657001506 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 645657001507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657001508 active site 645657001509 phosphorylation site [posttranslational modification] 645657001510 intermolecular recognition site; other site 645657001511 dimerization interface [polypeptide binding]; other site 645657001512 HTH domain; Region: HTH_11; cl17392 645657001513 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 645657001514 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 645657001515 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 645657001516 Domain of unknown function DUF20; Region: UPF0118; pfam01594 645657001517 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645657001518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657001519 Walker A/P-loop; other site 645657001520 ATP binding site [chemical binding]; other site 645657001521 Q-loop/lid; other site 645657001522 ABC transporter signature motif; other site 645657001523 Walker B; other site 645657001524 D-loop; other site 645657001525 H-loop/switch region; other site 645657001526 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 645657001527 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645657001528 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 645657001529 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 645657001530 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 645657001531 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 645657001532 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 645657001533 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 645657001534 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 645657001535 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 645657001536 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 645657001537 catalytic residues [active] 645657001538 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 645657001539 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 645657001540 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 645657001541 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 645657001542 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 645657001543 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645657001544 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645657001545 helicase 45; Provisional; Region: PTZ00424 645657001546 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 645657001547 ATP binding site [chemical binding]; other site 645657001548 Mg++ binding site [ion binding]; other site 645657001549 motif III; other site 645657001550 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657001551 nucleotide binding region [chemical binding]; other site 645657001552 ATP-binding site [chemical binding]; other site 645657001553 Uncharacterized conserved protein [Function unknown]; Region: COG3402 645657001554 Predicted membrane protein [Function unknown]; Region: COG3428 645657001555 Bacterial PH domain; Region: DUF304; pfam03703 645657001556 Bacterial PH domain; Region: DUF304; pfam03703 645657001557 Bacterial PH domain; Region: DUF304; pfam03703 645657001558 Rhomboid family; Region: Rhomboid; pfam01694 645657001559 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 645657001560 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 645657001561 alanine racemase; Region: alr; TIGR00492 645657001562 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 645657001563 active site 645657001564 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645657001565 dimer interface [polypeptide binding]; other site 645657001566 substrate binding site [chemical binding]; other site 645657001567 catalytic residues [active] 645657001568 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 645657001569 ribbon-helix-helix domain containing protein; Region: PHA00617 645657001570 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 645657001571 Rsbr N terminal; Region: Rsbr_N; pfam08678 645657001572 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 645657001573 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 645657001574 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 645657001575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657001576 ATP binding site [chemical binding]; other site 645657001577 Mg2+ binding site [ion binding]; other site 645657001578 G-X-G motif; other site 645657001579 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 645657001580 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 645657001581 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 645657001582 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 645657001583 anti sigma factor interaction site; other site 645657001584 regulatory phosphorylation site [posttranslational modification]; other site 645657001585 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 645657001586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657001587 ATP binding site [chemical binding]; other site 645657001588 Mg2+ binding site [ion binding]; other site 645657001589 G-X-G motif; other site 645657001590 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 645657001591 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657001592 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 645657001593 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657001594 DNA binding residues [nucleotide binding] 645657001595 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 645657001596 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 645657001597 hypothetical protein; Provisional; Region: PRK02268 645657001598 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657001599 MarR family; Region: MarR; pfam01047 645657001600 MarR family; Region: MarR_2; cl17246 645657001601 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 645657001602 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 645657001603 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 645657001604 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 645657001605 RNA binding site [nucleotide binding]; other site 645657001606 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 645657001607 hypothetical protein; Provisional; Region: PRK04351 645657001608 integrase; Provisional; Region: int; PHA02601 645657001609 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 645657001610 Int/Topo IB signature motif; other site 645657001611 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 645657001612 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645657001613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657001614 non-specific DNA binding site [nucleotide binding]; other site 645657001615 salt bridge; other site 645657001616 sequence-specific DNA binding site [nucleotide binding]; other site 645657001617 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 645657001618 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 645657001619 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 645657001620 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 645657001621 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 645657001622 Replication initiation factor; Region: Rep_trans; pfam02486 645657001623 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 645657001624 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 645657001625 TcpE family; Region: TcpE; pfam12648 645657001626 AAA-like domain; Region: AAA_10; pfam12846 645657001627 Domain of unknown function (DUF1874); Region: DUF1874; pfam08960 645657001628 Neuroendocrine-specific golgi protein P55 (NESP55); Region: NESP55; pfam06390 645657001629 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 645657001630 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 645657001631 N-acetyl-D-glucosamine binding site [chemical binding]; other site 645657001632 catalytic residue [active] 645657001633 NlpC/P60 family; Region: NLPC_P60; pfam00877 645657001634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657001635 binding surface 645657001636 TPR motif; other site 645657001637 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657001638 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 645657001639 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 645657001640 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 645657001641 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 645657001642 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 645657001643 putative transporter; Provisional; Region: PRK11021 645657001644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657001645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657001646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 645657001647 dimerization interface [polypeptide binding]; other site 645657001648 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 645657001649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645657001650 LXG domain of WXG superfamily; Region: LXG; pfam04740 645657001651 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645657001652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657001653 non-specific DNA binding site [nucleotide binding]; other site 645657001654 salt bridge; other site 645657001655 sequence-specific DNA binding site [nucleotide binding]; other site 645657001656 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 645657001657 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 645657001658 conserved cys residue [active] 645657001659 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 645657001660 DNA-binding site [nucleotide binding]; DNA binding site 645657001661 RNA-binding motif; other site 645657001662 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 645657001663 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 645657001664 EamA-like transporter family; Region: EamA; pfam00892 645657001665 EamA-like transporter family; Region: EamA; pfam00892 645657001666 Cupin domain; Region: Cupin_2; pfam07883 645657001667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645657001668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657001669 EamA-like transporter family; Region: EamA; pfam00892 645657001670 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 645657001671 EamA-like transporter family; Region: EamA; pfam00892 645657001672 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645657001673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657001674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 645657001675 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 645657001676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657001677 DNA-binding site [nucleotide binding]; DNA binding site 645657001678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657001679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657001680 homodimer interface [polypeptide binding]; other site 645657001681 catalytic residue [active] 645657001682 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657001683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 645657001684 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 645657001685 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 645657001686 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 645657001687 dimerization domain swap beta strand [polypeptide binding]; other site 645657001688 regulatory protein interface [polypeptide binding]; other site 645657001689 regulatory phosphorylation site [posttranslational modification]; other site 645657001690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657001691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657001692 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 645657001693 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 645657001694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657001695 DNA-binding site [nucleotide binding]; DNA binding site 645657001696 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657001697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657001698 homodimer interface [polypeptide binding]; other site 645657001699 catalytic residue [active] 645657001700 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 645657001701 putative active site [active] 645657001702 putative catalytic site [active] 645657001703 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 645657001704 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 645657001705 Uncharacterized conserved protein [Function unknown]; Region: COG1284 645657001706 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645657001707 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645657001708 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 645657001709 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657001710 dimerization interface [polypeptide binding]; other site 645657001711 putative DNA binding site [nucleotide binding]; other site 645657001712 putative Zn2+ binding site [ion binding]; other site 645657001713 arsenical pump membrane protein; Provisional; Region: PRK15445 645657001714 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 645657001715 transmembrane helices; other site 645657001716 Low molecular weight phosphatase family; Region: LMWPc; cl00105 645657001717 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 645657001718 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 645657001719 EamA-like transporter family; Region: EamA; pfam00892 645657001720 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 645657001721 EamA-like transporter family; Region: EamA; pfam00892 645657001722 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 645657001723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657001724 DNA-binding site [nucleotide binding]; DNA binding site 645657001725 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657001726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657001727 homodimer interface [polypeptide binding]; other site 645657001728 catalytic residue [active] 645657001729 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 645657001730 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645657001731 catalytic residue [active] 645657001732 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 645657001733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657001734 putative DNA binding site [nucleotide binding]; other site 645657001735 putative Zn2+ binding site [ion binding]; other site 645657001736 Uncharacterized conserved protein [Function unknown]; Region: COG2128 645657001737 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 645657001738 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 645657001739 Histidine kinase; Region: HisKA_3; pfam07730 645657001740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657001741 ATP binding site [chemical binding]; other site 645657001742 Mg2+ binding site [ion binding]; other site 645657001743 G-X-G motif; other site 645657001744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645657001745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657001746 active site 645657001747 phosphorylation site [posttranslational modification] 645657001748 intermolecular recognition site; other site 645657001749 dimerization interface [polypeptide binding]; other site 645657001750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645657001751 DNA binding residues [nucleotide binding] 645657001752 dimerization interface [polypeptide binding]; other site 645657001753 MMPL family; Region: MMPL; pfam03176 645657001754 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 645657001755 MMPL family; Region: MMPL; pfam03176 645657001756 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 645657001757 Protein of unknown function (DUF554); Region: DUF554; pfam04474 645657001758 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 645657001759 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645657001760 DNA binding residues [nucleotide binding] 645657001761 drug binding residues [chemical binding]; other site 645657001762 dimer interface [polypeptide binding]; other site 645657001763 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 645657001764 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 645657001765 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 645657001766 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 645657001767 dimer interface [polypeptide binding]; other site 645657001768 FMN binding site [chemical binding]; other site 645657001769 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 645657001770 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657001771 Zn binding site [ion binding]; other site 645657001772 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 645657001773 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657001774 Zn binding site [ion binding]; other site 645657001775 Predicted membrane protein [Function unknown]; Region: COG2259 645657001776 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 645657001777 catalytic residues [active] 645657001778 Transposase domain (DUF772); Region: DUF772; pfam05598 645657001779 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 645657001780 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 645657001781 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 645657001782 Predicted membrane protein [Function unknown]; Region: COG2323 645657001783 Predicted membrane protein [Function unknown]; Region: COG2323 645657001784 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 645657001785 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 645657001786 putative dimer interface [polypeptide binding]; other site 645657001787 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 645657001788 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657001789 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657001790 DoxX-like family; Region: DoxX_2; pfam13564 645657001791 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 645657001792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657001793 Coenzyme A binding pocket [chemical binding]; other site 645657001794 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 645657001795 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657001796 ABC transporter; Region: ABC_tran_2; pfam12848 645657001797 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657001798 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 645657001799 DinB family; Region: DinB; pfam05163 645657001800 DinB superfamily; Region: DinB_2; pfam12867 645657001801 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657001802 MarR family; Region: MarR; pfam01047 645657001803 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 645657001804 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 645657001805 dimer interface [polypeptide binding]; other site 645657001806 FMN binding site [chemical binding]; other site 645657001807 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657001808 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657001809 putative DNA binding site [nucleotide binding]; other site 645657001810 putative Zn2+ binding site [ion binding]; other site 645657001811 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 645657001812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657001813 putative substrate translocation pore; other site 645657001814 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 645657001815 Transcriptional regulators [Transcription]; Region: GntR; COG1802 645657001816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657001817 DNA-binding site [nucleotide binding]; DNA binding site 645657001818 FCD domain; Region: FCD; pfam07729 645657001819 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 645657001820 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657001821 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657001822 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 645657001823 active site 645657001824 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 645657001825 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 645657001826 homodimer interface [polypeptide binding]; other site 645657001827 active site 645657001828 TDP-binding site; other site 645657001829 acceptor substrate-binding pocket; other site 645657001830 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 645657001831 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 645657001832 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 645657001833 dimer interface [polypeptide binding]; other site 645657001834 active site 645657001835 Uncharacterized conserved protein [Function unknown]; Region: COG5646 645657001836 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 645657001837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657001838 Coenzyme A binding pocket [chemical binding]; other site 645657001839 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 645657001840 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645657001841 Zn2+ binding site [ion binding]; other site 645657001842 Mg2+ binding site [ion binding]; other site 645657001843 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 645657001844 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 645657001845 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 645657001846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657001847 putative substrate translocation pore; other site 645657001848 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 645657001849 active site 645657001850 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 645657001851 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 645657001852 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 645657001853 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 645657001854 beta-galactosidase; Region: BGL; TIGR03356 645657001855 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 645657001856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657001857 DNA-binding site [nucleotide binding]; DNA binding site 645657001858 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 645657001859 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 645657001860 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645657001861 nucleotide binding site [chemical binding]; other site 645657001862 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 645657001863 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 645657001864 Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546 645657001865 dinuclear metal binding motif [ion binding]; other site 645657001866 thiamine-monophosphate kinase; Region: thiL; TIGR01379 645657001867 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 645657001868 ATP binding site [chemical binding]; other site 645657001869 dimerization interface [polypeptide binding]; other site 645657001870 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 645657001871 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 645657001872 Glycoprotease family; Region: Peptidase_M22; pfam00814 645657001873 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 645657001874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657001875 Coenzyme A binding pocket [chemical binding]; other site 645657001876 UGMP family protein; Validated; Region: PRK09604 645657001877 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645657001878 nucleotide binding site [chemical binding]; other site 645657001879 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 645657001880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657001881 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657001882 ABC transporter; Region: ABC_tran_2; pfam12848 645657001883 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657001884 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 645657001885 trimer interface [polypeptide binding]; other site 645657001886 dimer interface [polypeptide binding]; other site 645657001887 putative active site [active] 645657001888 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 645657001889 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 645657001890 CoA binding domain; Region: CoA_binding; pfam02629 645657001891 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 645657001892 Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945 645657001893 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 645657001894 CAAX protease self-immunity; Region: Abi; pfam02517 645657001895 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 645657001896 oligomerisation interface [polypeptide binding]; other site 645657001897 mobile loop; other site 645657001898 roof hairpin; other site 645657001899 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 645657001900 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 645657001901 ring oligomerisation interface [polypeptide binding]; other site 645657001902 ATP/Mg binding site [chemical binding]; other site 645657001903 stacking interactions; other site 645657001904 hinge regions; other site 645657001905 Beta protein; Region: Beta_protein; pfam14350 645657001906 NB-ARC domain; Region: NB-ARC; pfam00931 645657001907 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657001908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657001909 TPR motif; other site 645657001910 TPR repeat; Region: TPR_11; pfam13414 645657001911 binding surface 645657001912 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 645657001913 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 645657001914 inhibitor binding site; inhibition site 645657001915 catalytic Zn binding site [ion binding]; other site 645657001916 structural Zn binding site [ion binding]; other site 645657001917 NADP binding site [chemical binding]; other site 645657001918 tetramer interface [polypeptide binding]; other site 645657001919 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 645657001920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657001921 putative substrate translocation pore; other site 645657001922 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 645657001923 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 645657001924 putative substrate binding site [chemical binding]; other site 645657001925 putative ATP binding site [chemical binding]; other site 645657001926 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 645657001927 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 645657001928 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 645657001929 DNA-directed RNA polymerase subunit F; Provisional; Region: PRK14981 645657001930 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 645657001931 Repair protein; Region: Repair_PSII; pfam04536 645657001932 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 645657001933 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 645657001934 Double zinc ribbon; Region: DZR; pfam12773 645657001935 Ion channel; Region: Ion_trans_2; pfam07885 645657001936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657001937 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 645657001938 putative substrate translocation pore; other site 645657001939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657001940 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 645657001941 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 645657001942 putative NAD(P) binding site [chemical binding]; other site 645657001943 catalytic Zn binding site [ion binding]; other site 645657001944 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 645657001945 Homeodomain-like domain; Region: HTH_23; pfam13384 645657001946 putative transposase OrfB; Reviewed; Region: PHA02517 645657001947 HTH-like domain; Region: HTH_21; pfam13276 645657001948 Integrase core domain; Region: rve; pfam00665 645657001949 Integrase core domain; Region: rve_3; pfam13683 645657001950 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 645657001951 Cold-inducible protein YdjO; Region: YdjO; pfam14169 645657001952 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 645657001953 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 645657001954 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 645657001955 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 645657001956 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 645657001957 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 645657001958 Multicopper oxidase; Region: Cu-oxidase; pfam00394 645657001959 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 645657001960 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 645657001961 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 645657001962 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 645657001963 MoxR-like ATPases [General function prediction only]; Region: COG0714 645657001964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657001965 Walker A motif; other site 645657001966 ATP binding site [chemical binding]; other site 645657001967 Walker B motif; other site 645657001968 arginine finger; other site 645657001969 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 645657001970 Protein of unknown function DUF58; Region: DUF58; pfam01882 645657001971 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 645657001972 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 645657001973 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 645657001974 GMP synthase; Reviewed; Region: guaA; PRK00074 645657001975 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 645657001976 AMP/PPi binding site [chemical binding]; other site 645657001977 candidate oxyanion hole; other site 645657001978 catalytic triad [active] 645657001979 potential glutamine specificity residues [chemical binding]; other site 645657001980 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 645657001981 ATP Binding subdomain [chemical binding]; other site 645657001982 Ligand Binding sites [chemical binding]; other site 645657001983 Dimerization subdomain; other site 645657001984 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 645657001985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 645657001986 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 645657001987 NETI protein; Region: NETI; pfam14044 645657001988 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 645657001989 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 645657001990 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 645657001991 NAD binding site [chemical binding]; other site 645657001992 ATP-grasp domain; Region: ATP-grasp; pfam02222 645657001993 adenylosuccinate lyase; Provisional; Region: PRK07492 645657001994 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 645657001995 tetramer interface [polypeptide binding]; other site 645657001996 active site 645657001997 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 645657001998 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 645657001999 ATP binding site [chemical binding]; other site 645657002000 active site 645657002001 substrate binding site [chemical binding]; other site 645657002002 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 645657002003 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 645657002004 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 645657002005 putative active site [active] 645657002006 catalytic triad [active] 645657002007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 645657002008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 645657002009 dimerization interface [polypeptide binding]; other site 645657002010 ATP binding site [chemical binding]; other site 645657002011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 645657002012 dimerization interface [polypeptide binding]; other site 645657002013 ATP binding site [chemical binding]; other site 645657002014 amidophosphoribosyltransferase; Provisional; Region: PRK07631 645657002015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 645657002016 active site 645657002017 tetramer interface [polypeptide binding]; other site 645657002018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645657002019 active site 645657002020 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 645657002021 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 645657002022 dimerization interface [polypeptide binding]; other site 645657002023 putative ATP binding site [chemical binding]; other site 645657002024 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 645657002025 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 645657002026 active site 645657002027 substrate binding site [chemical binding]; other site 645657002028 cosubstrate binding site; other site 645657002029 catalytic site [active] 645657002030 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 645657002031 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 645657002032 purine monophosphate binding site [chemical binding]; other site 645657002033 dimer interface [polypeptide binding]; other site 645657002034 putative catalytic residues [active] 645657002035 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 645657002036 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 645657002037 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 645657002038 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 645657002039 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 645657002040 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 645657002041 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 645657002042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657002043 putative DNA binding site [nucleotide binding]; other site 645657002044 putative Zn2+ binding site [ion binding]; other site 645657002045 AsnC family; Region: AsnC_trans_reg; pfam01037 645657002046 putative transporter; Provisional; Region: PRK11021 645657002047 Spore germination protein; Region: Spore_permease; cl17796 645657002048 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 645657002049 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645657002050 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 645657002051 active site 645657002052 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645657002053 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 645657002054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 645657002055 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 645657002056 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 645657002057 active site 645657002058 FMN binding site [chemical binding]; other site 645657002059 substrate binding site [chemical binding]; other site 645657002060 3Fe-4S cluster binding site [ion binding]; other site 645657002061 PcrB family; Region: PcrB; pfam01884 645657002062 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 645657002063 substrate binding site [chemical binding]; other site 645657002064 putative active site [active] 645657002065 dimer interface [polypeptide binding]; other site 645657002066 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 645657002067 Part of AAA domain; Region: AAA_19; pfam13245 645657002068 Family description; Region: UvrD_C_2; pfam13538 645657002069 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 645657002070 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 645657002071 nucleotide binding pocket [chemical binding]; other site 645657002072 K-X-D-G motif; other site 645657002073 catalytic site [active] 645657002074 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 645657002075 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 645657002076 Helix-hairpin-helix motif; Region: HHH; pfam00633 645657002077 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 645657002078 Dimer interface [polypeptide binding]; other site 645657002079 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 645657002080 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 645657002081 putative dimer interface [polypeptide binding]; other site 645657002082 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 645657002083 putative dimer interface [polypeptide binding]; other site 645657002084 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 645657002085 Homeodomain-like domain; Region: HTH_23; pfam13384 645657002086 putative transposase OrfB; Reviewed; Region: PHA02517 645657002087 HTH-like domain; Region: HTH_21; pfam13276 645657002088 Integrase core domain; Region: rve; pfam00665 645657002089 Integrase core domain; Region: rve_3; pfam13683 645657002090 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 645657002091 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 645657002092 active site 645657002093 ATP binding site [chemical binding]; other site 645657002094 substrate binding site [chemical binding]; other site 645657002095 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 645657002096 MgtC family; Region: MgtC; pfam02308 645657002097 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 645657002098 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 645657002099 Na binding site [ion binding]; other site 645657002100 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 645657002101 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 645657002102 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 645657002103 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 645657002104 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 645657002105 GatB domain; Region: GatB_Yqey; pfam02637 645657002106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657002107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657002108 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 645657002109 Protein export membrane protein; Region: SecD_SecF; cl14618 645657002110 Protein export membrane protein; Region: SecD_SecF; cl14618 645657002111 putative lipid kinase; Reviewed; Region: PRK13337 645657002112 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 645657002113 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 645657002114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 645657002115 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 645657002116 SIR2-like domain; Region: SIR2_2; pfam13289 645657002117 Protein of unknown function, DUF600; Region: DUF600; cl04640 645657002118 Uncharacterized conserved protein [Function unknown]; Region: COG5444 645657002119 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 645657002120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657002121 binding surface 645657002122 TPR motif; other site 645657002123 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657002124 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657002125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657002126 TPR motif; other site 645657002127 binding surface 645657002128 hypothetical protein; Provisional; Region: PRK12378 645657002129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657002130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657002131 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 645657002132 CotJB protein; Region: CotJB; pfam12652 645657002133 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 645657002134 dimanganese center [ion binding]; other site 645657002135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657002136 Coenzyme A binding pocket [chemical binding]; other site 645657002137 YesK-like protein; Region: YesK; pfam14150 645657002138 YesK-like protein; Region: YesK; pfam14150 645657002139 Predicted integral membrane protein [Function unknown]; Region: COG5578 645657002140 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 645657002141 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 645657002142 dimerization interface [polypeptide binding]; other site 645657002143 Histidine kinase; Region: His_kinase; pfam06580 645657002144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657002145 ATP binding site [chemical binding]; other site 645657002146 Mg2+ binding site [ion binding]; other site 645657002147 G-X-G motif; other site 645657002148 Response regulator receiver domain; Region: Response_reg; pfam00072 645657002149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657002150 active site 645657002151 phosphorylation site [posttranslational modification] 645657002152 intermolecular recognition site; other site 645657002153 dimerization interface [polypeptide binding]; other site 645657002154 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645657002155 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657002156 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 645657002157 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 645657002158 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 645657002159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657002160 dimer interface [polypeptide binding]; other site 645657002161 conserved gate region; other site 645657002162 putative PBP binding loops; other site 645657002163 ABC-ATPase subunit interface; other site 645657002164 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 645657002165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657002166 dimer interface [polypeptide binding]; other site 645657002167 conserved gate region; other site 645657002168 putative PBP binding loops; other site 645657002169 ABC-ATPase subunit interface; other site 645657002170 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 645657002171 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645657002172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657002173 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 645657002174 active site 645657002175 catalytic triad [active] 645657002176 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 645657002177 Predicted integral membrane protein [Function unknown]; Region: COG5578 645657002178 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 645657002179 metal binding site [ion binding]; metal-binding site 645657002180 active site 645657002181 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 645657002182 metal binding site [ion binding]; metal-binding site 645657002183 active site 645657002184 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 645657002185 active site 645657002186 catalytic triad [active] 645657002187 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 645657002188 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 645657002189 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 645657002190 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 645657002191 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 645657002192 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 645657002193 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 645657002194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657002195 dimer interface [polypeptide binding]; other site 645657002196 putative PBP binding loops; other site 645657002197 ABC-ATPase subunit interface; other site 645657002198 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 645657002199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657002200 dimer interface [polypeptide binding]; other site 645657002201 conserved gate region; other site 645657002202 putative PBP binding loops; other site 645657002203 ABC-ATPase subunit interface; other site 645657002204 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 645657002205 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 645657002206 NAD binding site [chemical binding]; other site 645657002207 sugar binding site [chemical binding]; other site 645657002208 divalent metal binding site [ion binding]; other site 645657002209 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 645657002210 dimer interface [polypeptide binding]; other site 645657002211 Predicted membrane protein [Function unknown]; Region: COG2323 645657002212 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 645657002213 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657002214 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 645657002215 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 645657002216 Uncharacterized small protein [Function unknown]; Region: COG5583 645657002217 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 645657002218 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 645657002219 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 645657002220 Transposase, Mutator family; Region: Transposase_mut; pfam00872 645657002221 MULE transposase domain; Region: MULE; pfam10551 645657002222 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 645657002223 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 645657002224 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 645657002225 Cytochrome P450; Region: p450; pfam00067 645657002226 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 645657002227 Flavodoxin; Region: Flavodoxin_1; pfam00258 645657002228 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 645657002229 FAD binding pocket [chemical binding]; other site 645657002230 FAD binding motif [chemical binding]; other site 645657002231 catalytic residues [active] 645657002232 NAD binding pocket [chemical binding]; other site 645657002233 phosphate binding motif [ion binding]; other site 645657002234 beta-alpha-beta structure motif; other site 645657002235 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 645657002236 Sulfatase; Region: Sulfatase; pfam00884 645657002237 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 645657002238 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 645657002239 substrate binding site; other site 645657002240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645657002241 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 645657002242 NAD(P) binding site [chemical binding]; other site 645657002243 active site 645657002244 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 645657002245 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 645657002246 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 645657002247 active site 645657002248 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 645657002249 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 645657002250 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657002251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657002252 putative substrate translocation pore; other site 645657002253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657002254 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 645657002255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657002256 active site 645657002257 motif I; other site 645657002258 motif II; other site 645657002259 amino acid transporter; Region: 2A0306; TIGR00909 645657002260 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 645657002261 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 645657002262 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 645657002263 NAD(P) binding site [chemical binding]; other site 645657002264 catalytic residues [active] 645657002265 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 645657002266 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 645657002267 dimer interface [polypeptide binding]; other site 645657002268 putative CheW interface [polypeptide binding]; other site 645657002269 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 645657002270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657002271 Walker A/P-loop; other site 645657002272 ATP binding site [chemical binding]; other site 645657002273 Q-loop/lid; other site 645657002274 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657002275 ABC transporter signature motif; other site 645657002276 Walker B; other site 645657002277 D-loop; other site 645657002278 ABC transporter; Region: ABC_tran_2; pfam12848 645657002279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657002280 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 645657002281 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645657002282 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 645657002283 DNA binding residues [nucleotide binding] 645657002284 putative dimer interface [polypeptide binding]; other site 645657002285 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 645657002286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657002287 putative substrate translocation pore; other site 645657002288 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 645657002289 Homeodomain-like domain; Region: HTH_23; pfam13384 645657002290 putative transposase OrfB; Reviewed; Region: PHA02517 645657002291 HTH-like domain; Region: HTH_21; pfam13276 645657002292 Integrase core domain; Region: rve; pfam00665 645657002293 Integrase core domain; Region: rve_3; pfam13683 645657002294 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 645657002295 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657002296 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657002297 ABC transporter; Region: ABC_tran_2; pfam12848 645657002298 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657002299 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 645657002300 DEAD-like helicases superfamily; Region: DEXDc; smart00487 645657002301 ATP binding site [chemical binding]; other site 645657002302 Mg++ binding site [ion binding]; other site 645657002303 motif III; other site 645657002304 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657002305 nucleotide binding region [chemical binding]; other site 645657002306 ATP-binding site [chemical binding]; other site 645657002307 Heat induced stress protein YflT; Region: YflT; pfam11181 645657002308 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 645657002309 Amb_all domain; Region: Amb_all; smart00656 645657002310 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 645657002311 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 645657002312 transmembrane helices; other site 645657002313 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 645657002314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657002315 ATP binding site [chemical binding]; other site 645657002316 Mg2+ binding site [ion binding]; other site 645657002317 G-X-G motif; other site 645657002318 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 645657002319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657002320 active site 645657002321 phosphorylation site [posttranslational modification] 645657002322 intermolecular recognition site; other site 645657002323 dimerization interface [polypeptide binding]; other site 645657002324 Transcriptional regulator; Region: CitT; pfam12431 645657002325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 645657002326 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 645657002327 Citrate transporter; Region: CitMHS; pfam03600 645657002328 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645657002329 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 645657002330 active site 645657002331 dimer interface [polypeptide binding]; other site 645657002332 acylphosphatase; Provisional; Region: PRK14420 645657002333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 645657002334 MOSC domain; Region: MOSC; pfam03473 645657002335 3-alpha domain; Region: 3-alpha; pfam03475 645657002336 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 645657002337 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 645657002338 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 645657002339 active site 645657002340 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 645657002341 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645657002342 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645657002343 active site turn [active] 645657002344 phosphorylation site [posttranslational modification] 645657002345 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 645657002346 Sulfatase; Region: Sulfatase; pfam00884 645657002347 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 645657002348 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 645657002349 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 645657002350 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 645657002351 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 645657002352 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645657002353 active site turn [active] 645657002354 phosphorylation site [posttranslational modification] 645657002355 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645657002356 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 645657002357 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 645657002358 Ca binding site [ion binding]; other site 645657002359 active site 645657002360 catalytic site [active] 645657002361 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 645657002362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657002363 DNA-binding site [nucleotide binding]; DNA binding site 645657002364 UTRA domain; Region: UTRA; pfam07702 645657002365 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 645657002366 dimer interface [polypeptide binding]; other site 645657002367 FMN binding site [chemical binding]; other site 645657002368 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 645657002369 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 645657002370 active site 645657002371 metal binding site [ion binding]; metal-binding site 645657002372 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 645657002373 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 645657002374 active site 645657002375 metal binding site [ion binding]; metal-binding site 645657002376 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 645657002377 intracellular protease, PfpI family; Region: PfpI; TIGR01382 645657002378 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 645657002379 proposed catalytic triad [active] 645657002380 conserved cys residue [active] 645657002381 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 645657002382 Homeodomain-like domain; Region: HTH_23; pfam13384 645657002383 putative transposase OrfB; Reviewed; Region: PHA02517 645657002384 HTH-like domain; Region: HTH_21; pfam13276 645657002385 Integrase core domain; Region: rve; pfam00665 645657002386 Integrase core domain; Region: rve_3; pfam13683 645657002387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657002388 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657002389 putative substrate translocation pore; other site 645657002390 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 645657002391 Low molecular weight phosphatase family; Region: LMWPc; cd00115 645657002392 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 645657002393 active site 645657002394 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 645657002395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657002396 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657002397 putative substrate translocation pore; other site 645657002398 calcium/proton exchanger (cax); Region: cax; TIGR00378 645657002399 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 645657002400 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 645657002401 YfkD-like protein; Region: YfkD; pfam14167 645657002402 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 645657002403 Mechanosensitive ion channel; Region: MS_channel; pfam00924 645657002404 Radical SAM superfamily; Region: Radical_SAM; pfam04055 645657002405 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645657002406 FeS/SAM binding site; other site 645657002407 YfkB-like domain; Region: YfkB; pfam08756 645657002408 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 645657002409 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 645657002410 NodB motif; other site 645657002411 active site 645657002412 catalytic site [active] 645657002413 Cd binding site [ion binding]; other site 645657002414 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 645657002415 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 645657002416 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 645657002417 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 645657002418 oligomer interface [polypeptide binding]; other site 645657002419 metal binding site [ion binding]; metal-binding site 645657002420 metal binding site [ion binding]; metal-binding site 645657002421 putative Cl binding site [ion binding]; other site 645657002422 aspartate ring; other site 645657002423 basic sphincter; other site 645657002424 hydrophobic gate; other site 645657002425 periplasmic entrance; other site 645657002426 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 645657002427 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 645657002428 minor groove reading motif; other site 645657002429 helix-hairpin-helix signature motif; other site 645657002430 substrate binding pocket [chemical binding]; other site 645657002431 active site 645657002432 TRAM domain; Region: TRAM; pfam01938 645657002433 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 645657002434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657002435 S-adenosylmethionine binding site [chemical binding]; other site 645657002436 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 645657002437 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 645657002438 FMN binding site [chemical binding]; other site 645657002439 active site 645657002440 catalytic residues [active] 645657002441 substrate binding site [chemical binding]; other site 645657002442 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 645657002443 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 645657002444 tetramer interface [polypeptide binding]; other site 645657002445 TPP-binding site [chemical binding]; other site 645657002446 heterodimer interface [polypeptide binding]; other site 645657002447 phosphorylation loop region [posttranslational modification] 645657002448 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 645657002449 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 645657002450 alpha subunit interface [polypeptide binding]; other site 645657002451 TPP binding site [chemical binding]; other site 645657002452 heterodimer interface [polypeptide binding]; other site 645657002453 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 645657002454 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 645657002455 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 645657002456 E3 interaction surface; other site 645657002457 lipoyl attachment site [posttranslational modification]; other site 645657002458 e3 binding domain; Region: E3_binding; pfam02817 645657002459 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 645657002460 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 645657002461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645657002462 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 645657002463 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 645657002464 GAF domain; Region: GAF; pfam01590 645657002465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657002466 Walker A motif; other site 645657002467 ATP binding site [chemical binding]; other site 645657002468 Walker B motif; other site 645657002469 arginine finger; other site 645657002470 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 645657002471 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 645657002472 hypothetical protein; Provisional; Region: PRK02237 645657002473 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 645657002474 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 645657002475 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 645657002476 NAD binding site [chemical binding]; other site 645657002477 sugar binding site [chemical binding]; other site 645657002478 divalent metal binding site [ion binding]; other site 645657002479 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 645657002480 dimer interface [polypeptide binding]; other site 645657002481 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 645657002482 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 645657002483 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 645657002484 putative active site [active] 645657002485 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 645657002486 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 645657002487 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645657002488 active site turn [active] 645657002489 phosphorylation site [posttranslational modification] 645657002490 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 645657002491 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 645657002492 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645657002493 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645657002494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657002495 Walker A/P-loop; other site 645657002496 ATP binding site [chemical binding]; other site 645657002497 Q-loop/lid; other site 645657002498 ABC transporter signature motif; other site 645657002499 Walker B; other site 645657002500 D-loop; other site 645657002501 H-loop/switch region; other site 645657002502 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645657002503 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645657002504 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 645657002505 Walker A/P-loop; other site 645657002506 ATP binding site [chemical binding]; other site 645657002507 Q-loop/lid; other site 645657002508 ABC transporter signature motif; other site 645657002509 Walker B; other site 645657002510 D-loop; other site 645657002511 H-loop/switch region; other site 645657002512 Predicted membrane protein [Function unknown]; Region: COG2259 645657002513 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 645657002514 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 645657002515 putative metal binding site [ion binding]; other site 645657002516 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 645657002517 active site 645657002518 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 645657002519 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 645657002520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657002521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657002522 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 645657002523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657002524 putative substrate translocation pore; other site 645657002525 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 645657002526 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 645657002527 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 645657002528 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 645657002529 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 645657002530 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 645657002531 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 645657002532 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 645657002533 Histidine kinase; Region: HisKA_3; pfam07730 645657002534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657002535 ATP binding site [chemical binding]; other site 645657002536 Mg2+ binding site [ion binding]; other site 645657002537 G-X-G motif; other site 645657002538 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645657002539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657002540 active site 645657002541 phosphorylation site [posttranslational modification] 645657002542 intermolecular recognition site; other site 645657002543 dimerization interface [polypeptide binding]; other site 645657002544 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645657002545 DNA binding residues [nucleotide binding] 645657002546 dimerization interface [polypeptide binding]; other site 645657002547 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645657002548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657002549 Walker A/P-loop; other site 645657002550 ATP binding site [chemical binding]; other site 645657002551 Q-loop/lid; other site 645657002552 ABC transporter signature motif; other site 645657002553 Walker B; other site 645657002554 D-loop; other site 645657002555 H-loop/switch region; other site 645657002556 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 645657002557 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 645657002558 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645657002559 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 645657002560 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 645657002561 Predicted transcriptional regulators [Transcription]; Region: COG1695 645657002562 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 645657002563 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 645657002564 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 645657002565 Lipase (class 2); Region: Lipase_2; pfam01674 645657002566 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 645657002567 Acyltransferase family; Region: Acyl_transf_3; pfam01757 645657002568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657002569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657002570 H+ Antiporter protein; Region: 2A0121; TIGR00900 645657002571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657002572 putative substrate translocation pore; other site 645657002573 metal-dependent hydrolase; Provisional; Region: PRK13291 645657002574 DinB superfamily; Region: DinB_2; pfam12867 645657002575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657002576 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657002577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657002578 putative substrate translocation pore; other site 645657002579 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657002580 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657002581 putative Zn2+ binding site [ion binding]; other site 645657002582 putative DNA binding site [nucleotide binding]; other site 645657002583 Predicted integral membrane protein [Function unknown]; Region: COG0392 645657002584 Uncharacterized conserved protein [Function unknown]; Region: COG2898 645657002585 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 645657002586 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 645657002587 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 645657002588 siderophore binding site; other site 645657002589 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 645657002590 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645657002591 ABC-ATPase subunit interface; other site 645657002592 dimer interface [polypeptide binding]; other site 645657002593 putative PBP binding regions; other site 645657002594 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 645657002595 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645657002596 ABC-ATPase subunit interface; other site 645657002597 dimer interface [polypeptide binding]; other site 645657002598 putative PBP binding regions; other site 645657002599 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 645657002600 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 645657002601 putative FMN binding site [chemical binding]; other site 645657002602 YfhD-like protein; Region: YfhD; pfam14151 645657002603 YfhE-like protein; Region: YfhE; pfam14152 645657002604 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 645657002605 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 645657002606 putative NAD(P) binding site [chemical binding]; other site 645657002607 putative active site [active] 645657002608 recombination regulator RecX; Provisional; Region: recX; PRK14135 645657002609 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 645657002610 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 645657002611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657002612 putative substrate translocation pore; other site 645657002613 Small acid-soluble spore protein K family; Region: SspK; pfam08176 645657002614 WVELL protein; Region: WVELL; pfam14043 645657002615 Bacterial SH3 domain; Region: SH3_3; pfam08239 645657002616 Bacterial SH3 domain; Region: SH3_3; cl17532 645657002617 Predicted integral membrane protein [Function unknown]; Region: COG5658 645657002618 SdpI/YhfL protein family; Region: SdpI; pfam13630 645657002619 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 645657002620 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 645657002621 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 645657002622 catalytic site [active] 645657002623 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 645657002624 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 645657002625 Ligand binding site; other site 645657002626 Putative Catalytic site; other site 645657002627 DXD motif; other site 645657002628 Predicted membrane protein [Function unknown]; Region: COG4485 645657002629 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 645657002630 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 645657002631 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 645657002632 minor groove reading motif; other site 645657002633 helix-hairpin-helix signature motif; other site 645657002634 substrate binding pocket [chemical binding]; other site 645657002635 active site 645657002636 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 645657002637 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 645657002638 DNA binding and oxoG recognition site [nucleotide binding] 645657002639 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 645657002640 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 645657002641 putative NAD(P) binding site [chemical binding]; other site 645657002642 active site 645657002643 YgaB-like protein; Region: YgaB; pfam14182 645657002644 hypothetical protein; Provisional; Region: PRK13662 645657002645 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645657002646 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645657002647 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 645657002648 Walker A/P-loop; other site 645657002649 ATP binding site [chemical binding]; other site 645657002650 Q-loop/lid; other site 645657002651 ABC transporter signature motif; other site 645657002652 Walker B; other site 645657002653 D-loop; other site 645657002654 H-loop/switch region; other site 645657002655 Predicted membrane protein [Function unknown]; Region: COG4129 645657002656 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 645657002657 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 645657002658 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645657002659 inhibitor-cofactor binding pocket; inhibition site 645657002660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657002661 catalytic residue [active] 645657002662 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 645657002663 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 645657002664 catalytic triad [active] 645657002665 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 645657002666 metal binding site 2 [ion binding]; metal-binding site 645657002667 putative DNA binding helix; other site 645657002668 metal binding site 1 [ion binding]; metal-binding site 645657002669 dimer interface [polypeptide binding]; other site 645657002670 structural Zn2+ binding site [ion binding]; other site 645657002671 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 645657002672 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 645657002673 SpoOM protein; Region: Spo0M; pfam07070 645657002674 Coat F domain; Region: Coat_F; pfam07875 645657002675 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 645657002676 active site pocket [active] 645657002677 oxyanion hole [active] 645657002678 catalytic triad [active] 645657002679 active site nucleophile [active] 645657002680 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 645657002681 ThiC-associated domain; Region: ThiC-associated; pfam13667 645657002682 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 645657002683 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 645657002684 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 645657002685 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 645657002686 tetramer interface [polypeptide binding]; other site 645657002687 heme binding pocket [chemical binding]; other site 645657002688 NADPH binding site [chemical binding]; other site 645657002689 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 645657002690 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 645657002691 Walker A/P-loop; other site 645657002692 ATP binding site [chemical binding]; other site 645657002693 Q-loop/lid; other site 645657002694 ABC transporter signature motif; other site 645657002695 Walker B; other site 645657002696 D-loop; other site 645657002697 H-loop/switch region; other site 645657002698 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 645657002699 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645657002700 substrate binding pocket [chemical binding]; other site 645657002701 membrane-bound complex binding site; other site 645657002702 hinge residues; other site 645657002703 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 645657002704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657002705 dimer interface [polypeptide binding]; other site 645657002706 conserved gate region; other site 645657002707 putative PBP binding loops; other site 645657002708 ABC-ATPase subunit interface; other site 645657002709 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 645657002710 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 645657002711 active site 645657002712 dimer interface [polypeptide binding]; other site 645657002713 non-prolyl cis peptide bond; other site 645657002714 insertion regions; other site 645657002715 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 645657002716 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645657002717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657002718 non-specific DNA binding site [nucleotide binding]; other site 645657002719 salt bridge; other site 645657002720 sequence-specific DNA binding site [nucleotide binding]; other site 645657002721 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 645657002722 epoxyqueuosine reductase; Region: TIGR00276 645657002723 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 645657002724 Putative amidase domain; Region: Amidase_6; pfam12671 645657002725 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 645657002726 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 645657002727 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 645657002728 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 645657002729 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 645657002730 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 645657002731 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 645657002732 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 645657002733 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657002734 MarR family; Region: MarR; pfam01047 645657002735 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 645657002736 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 645657002737 carboxyltransferase (CT) interaction site; other site 645657002738 biotinylation site [posttranslational modification]; other site 645657002739 HlyD family secretion protein; Region: HlyD_3; pfam13437 645657002740 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 645657002741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657002742 putative substrate translocation pore; other site 645657002743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657002744 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 645657002745 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 645657002746 Predicted transcriptional regulators [Transcription]; Region: COG1725 645657002747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657002748 DNA-binding site [nucleotide binding]; DNA binding site 645657002749 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 645657002750 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645657002751 Walker A/P-loop; other site 645657002752 ATP binding site [chemical binding]; other site 645657002753 Q-loop/lid; other site 645657002754 ABC transporter signature motif; other site 645657002755 Walker B; other site 645657002756 D-loop; other site 645657002757 H-loop/switch region; other site 645657002758 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645657002759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657002760 Walker A/P-loop; other site 645657002761 ATP binding site [chemical binding]; other site 645657002762 Q-loop/lid; other site 645657002763 ABC transporter signature motif; other site 645657002764 Walker B; other site 645657002765 D-loop; other site 645657002766 H-loop/switch region; other site 645657002767 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 645657002768 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645657002769 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 645657002770 DNA-binding site [nucleotide binding]; DNA binding site 645657002771 RNA-binding motif; other site 645657002772 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 645657002773 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 645657002774 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 645657002775 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 645657002776 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645657002777 metal binding site [ion binding]; metal-binding site 645657002778 active site 645657002779 I-site; other site 645657002780 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 645657002781 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 645657002782 LXG domain of WXG superfamily; Region: LXG; pfam04740 645657002783 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 645657002784 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 645657002785 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 645657002786 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 645657002787 Int/Topo IB signature motif; other site 645657002788 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 645657002789 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 645657002790 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 645657002791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657002792 binding surface 645657002793 TPR motif; other site 645657002794 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657002795 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 645657002796 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 645657002797 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 645657002798 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 645657002799 generic binding surface II; other site 645657002800 generic binding surface I; other site 645657002801 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 645657002802 generic binding surface II; other site 645657002803 generic binding surface I; other site 645657002804 Staphylococcal nuclease homologues; Region: SNc; smart00318 645657002805 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 645657002806 Catalytic site; other site 645657002807 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 645657002808 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 645657002809 putative active site [active] 645657002810 putative metal binding site [ion binding]; other site 645657002811 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 645657002812 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 645657002813 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 645657002814 active site 645657002815 catalytic site [active] 645657002816 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 645657002817 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645657002818 RNA binding surface [nucleotide binding]; other site 645657002819 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 645657002820 active site 645657002821 FOG: CBS domain [General function prediction only]; Region: COG0517 645657002822 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 645657002823 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 645657002824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657002825 motif II; other site 645657002826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657002827 Coenzyme A binding pocket [chemical binding]; other site 645657002828 Predicted amidohydrolase [General function prediction only]; Region: COG0388 645657002829 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 645657002830 putative active site [active] 645657002831 catalytic triad [active] 645657002832 putative dimer interface [polypeptide binding]; other site 645657002833 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 645657002834 aminotransferase; Validated; Region: PRK07678 645657002835 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645657002836 inhibitor-cofactor binding pocket; inhibition site 645657002837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657002838 catalytic residue [active] 645657002839 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 645657002840 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 645657002841 amphipathic channel; other site 645657002842 Asn-Pro-Ala signature motifs; other site 645657002843 glycerol kinase; Provisional; Region: glpK; PRK00047 645657002844 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 645657002845 N- and C-terminal domain interface [polypeptide binding]; other site 645657002846 active site 645657002847 MgATP binding site [chemical binding]; other site 645657002848 catalytic site [active] 645657002849 metal binding site [ion binding]; metal-binding site 645657002850 glycerol binding site [chemical binding]; other site 645657002851 homotetramer interface [polypeptide binding]; other site 645657002852 homodimer interface [polypeptide binding]; other site 645657002853 FBP binding site [chemical binding]; other site 645657002854 protein IIAGlc interface [polypeptide binding]; other site 645657002855 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 645657002856 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 645657002857 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 645657002858 active site 645657002859 substrate binding site [chemical binding]; other site 645657002860 metal binding site [ion binding]; metal-binding site 645657002861 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 645657002862 GAF domain; Region: GAF; pfam01590 645657002863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 645657002864 Histidine kinase; Region: HisKA_3; pfam07730 645657002865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657002866 ATP binding site [chemical binding]; other site 645657002867 Mg2+ binding site [ion binding]; other site 645657002868 G-X-G motif; other site 645657002869 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645657002870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657002871 active site 645657002872 phosphorylation site [posttranslational modification] 645657002873 intermolecular recognition site; other site 645657002874 dimerization interface [polypeptide binding]; other site 645657002875 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645657002876 DNA binding residues [nucleotide binding] 645657002877 dimerization interface [polypeptide binding]; other site 645657002878 Predicted flavoprotein [General function prediction only]; Region: COG0431 645657002879 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 645657002880 YhdB-like protein; Region: YhdB; pfam14148 645657002881 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 645657002882 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657002883 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657002884 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657002885 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657002886 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657002887 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645657002888 NlpC/P60 family; Region: NLPC_P60; pfam00877 645657002889 Transcriptional regulator; Region: Rrf2; cl17282 645657002890 Rrf2 family protein; Region: rrf2_super; TIGR00738 645657002891 Conserved TM helix; Region: TM_helix; pfam05552 645657002892 Conserved TM helix; Region: TM_helix; pfam05552 645657002893 Conserved TM helix; Region: TM_helix; pfam05552 645657002894 Conserved TM helix; Region: TM_helix; pfam05552 645657002895 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 645657002896 SpoVR like protein; Region: SpoVR; pfam04293 645657002897 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 645657002898 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 645657002899 dimer interface [polypeptide binding]; other site 645657002900 active site 645657002901 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657002902 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657002903 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657002904 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645657002905 NlpC/P60 family; Region: NLPC_P60; pfam00877 645657002906 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657002907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657002908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 645657002909 dimerization interface [polypeptide binding]; other site 645657002910 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 645657002911 dimer interface [polypeptide binding]; other site 645657002912 Citrate synthase; Region: Citrate_synt; pfam00285 645657002913 active site 645657002914 citrylCoA binding site [chemical binding]; other site 645657002915 oxalacetate/citrate binding site [chemical binding]; other site 645657002916 coenzyme A binding site [chemical binding]; other site 645657002917 catalytic triad [active] 645657002918 short chain dehydrogenase; Provisional; Region: PRK06701 645657002919 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 645657002920 NAD binding site [chemical binding]; other site 645657002921 metal binding site [ion binding]; metal-binding site 645657002922 active site 645657002923 amino acid transporter; Region: 2A0306; TIGR00909 645657002924 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 645657002925 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 645657002926 Na2 binding site [ion binding]; other site 645657002927 putative substrate binding site 1 [chemical binding]; other site 645657002928 Na binding site 1 [ion binding]; other site 645657002929 putative substrate binding site 2 [chemical binding]; other site 645657002930 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 645657002931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657002932 DNA-binding site [nucleotide binding]; DNA binding site 645657002933 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657002934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657002935 homodimer interface [polypeptide binding]; other site 645657002936 catalytic residue [active] 645657002937 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 645657002938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657002939 Coenzyme A binding pocket [chemical binding]; other site 645657002940 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 645657002941 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 645657002942 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 645657002943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657002944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657002945 DNA binding residues [nucleotide binding] 645657002946 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645657002947 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645657002948 active site 645657002949 catalytic tetrad [active] 645657002950 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 645657002951 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 645657002952 putative acyl-acceptor binding pocket; other site 645657002953 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 645657002954 Domain of unknown function DUF21; Region: DUF21; pfam01595 645657002955 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 645657002956 Transporter associated domain; Region: CorC_HlyC; smart01091 645657002957 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 645657002958 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 645657002959 DNA binding residues [nucleotide binding] 645657002960 putative dimer interface [polypeptide binding]; other site 645657002961 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 645657002962 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657002963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657002964 homodimer interface [polypeptide binding]; other site 645657002965 catalytic residue [active] 645657002966 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 645657002967 Domain of unknown function DUF21; Region: DUF21; pfam01595 645657002968 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 645657002969 Transporter associated domain; Region: CorC_HlyC; smart01091 645657002970 camphor resistance protein CrcB; Provisional; Region: PRK14213 645657002971 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 645657002972 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 645657002973 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 645657002974 active site 645657002975 catalytic site [active] 645657002976 metal binding site [ion binding]; metal-binding site 645657002977 dimer interface [polypeptide binding]; other site 645657002978 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 645657002979 Mechanosensitive ion channel; Region: MS_channel; pfam00924 645657002980 NAD-dependent deacetylase; Provisional; Region: PRK00481 645657002981 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 645657002982 NAD+ binding site [chemical binding]; other site 645657002983 substrate binding site [chemical binding]; other site 645657002984 Zn binding site [ion binding]; other site 645657002985 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 645657002986 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 645657002987 NodB motif; other site 645657002988 active site 645657002989 catalytic site [active] 645657002990 Zn binding site [ion binding]; other site 645657002991 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 645657002992 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 645657002993 homodimer interface [polypeptide binding]; other site 645657002994 substrate-cofactor binding pocket; other site 645657002995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657002996 catalytic residue [active] 645657002997 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 645657002998 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 645657002999 Ligand Binding Site [chemical binding]; other site 645657003000 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645657003001 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 645657003002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657003003 Walker A/P-loop; other site 645657003004 ATP binding site [chemical binding]; other site 645657003005 Q-loop/lid; other site 645657003006 ABC transporter signature motif; other site 645657003007 Walker B; other site 645657003008 D-loop; other site 645657003009 H-loop/switch region; other site 645657003010 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645657003011 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645657003012 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 645657003013 Walker A/P-loop; other site 645657003014 ATP binding site [chemical binding]; other site 645657003015 Q-loop/lid; other site 645657003016 ABC transporter signature motif; other site 645657003017 Walker B; other site 645657003018 D-loop; other site 645657003019 H-loop/switch region; other site 645657003020 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 645657003021 NADH(P)-binding; Region: NAD_binding_10; pfam13460 645657003022 NAD binding site [chemical binding]; other site 645657003023 substrate binding site [chemical binding]; other site 645657003024 putative active site [active] 645657003025 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 645657003026 Transposase domain (DUF772); Region: DUF772; pfam05598 645657003027 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 645657003028 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 645657003029 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 645657003030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 645657003031 hypothetical protein; Provisional; Region: PRK13676 645657003032 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 645657003033 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 645657003034 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 645657003035 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657003036 active site 645657003037 motif I; other site 645657003038 motif II; other site 645657003039 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 645657003040 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 645657003041 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645657003042 FeS/SAM binding site; other site 645657003043 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 645657003044 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 645657003045 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 645657003046 TrkA-C domain; Region: TrkA_C; pfam02080 645657003047 enoyl-CoA hydratase; Provisional; Region: PRK07659 645657003048 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 645657003049 substrate binding site [chemical binding]; other site 645657003050 oxyanion hole (OAH) forming residues; other site 645657003051 trimer interface [polypeptide binding]; other site 645657003052 YhzD-like protein; Region: YhzD; pfam14120 645657003053 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 645657003054 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 645657003055 Walker A/P-loop; other site 645657003056 ATP binding site [chemical binding]; other site 645657003057 Q-loop/lid; other site 645657003058 ABC transporter signature motif; other site 645657003059 Walker B; other site 645657003060 D-loop; other site 645657003061 H-loop/switch region; other site 645657003062 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 645657003063 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 645657003064 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 645657003065 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 645657003066 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 645657003067 active site 645657003068 metal binding site [ion binding]; metal-binding site 645657003069 DNA binding site [nucleotide binding] 645657003070 Uncharacterized conserved protein [Function unknown]; Region: COG4717 645657003071 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 645657003072 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 645657003073 generic binding surface I; other site 645657003074 generic binding surface II; other site 645657003075 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645657003076 Zn2+ binding site [ion binding]; other site 645657003077 Mg2+ binding site [ion binding]; other site 645657003078 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 645657003079 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 645657003080 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 645657003081 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 645657003082 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 645657003083 transcriptional regulator Hpr; Provisional; Region: PRK13777 645657003084 MarR family; Region: MarR; pfam01047 645657003085 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 645657003086 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 645657003087 homodimer interface [polypeptide binding]; other site 645657003088 substrate-cofactor binding pocket; other site 645657003089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657003090 catalytic residue [active] 645657003091 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 645657003092 HIT family signature motif; other site 645657003093 catalytic residue [active] 645657003094 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 645657003095 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645657003096 Walker A/P-loop; other site 645657003097 ATP binding site [chemical binding]; other site 645657003098 Q-loop/lid; other site 645657003099 ABC transporter signature motif; other site 645657003100 Walker B; other site 645657003101 D-loop; other site 645657003102 H-loop/switch region; other site 645657003103 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 645657003104 EcsC protein family; Region: EcsC; pfam12787 645657003105 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645657003106 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 645657003107 metal binding site [ion binding]; metal-binding site 645657003108 dimer interface [polypeptide binding]; other site 645657003109 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 645657003110 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 645657003111 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 645657003112 Transglycosylase; Region: Transgly; pfam00912 645657003113 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645657003114 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 645657003115 substrate binding site [chemical binding]; other site 645657003116 active site 645657003117 ferrochelatase; Provisional; Region: PRK12435 645657003118 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 645657003119 C-terminal domain interface [polypeptide binding]; other site 645657003120 active site 645657003121 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 645657003122 active site 645657003123 N-terminal domain interface [polypeptide binding]; other site 645657003124 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 645657003125 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 645657003126 SEA domain; Region: SEA; cl02507 645657003127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657003128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657003129 Predicted membrane protein [Function unknown]; Region: COG1511 645657003130 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 645657003131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657003132 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 645657003133 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 645657003134 dimer interface [polypeptide binding]; other site 645657003135 active site 645657003136 CoA binding pocket [chemical binding]; other site 645657003137 Predicted membrane protein [Function unknown]; Region: COG4377 645657003138 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 645657003139 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 645657003140 putative oligomer interface [polypeptide binding]; other site 645657003141 putative active site [active] 645657003142 metal binding site [ion binding]; metal-binding site 645657003143 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 645657003144 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 645657003145 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 645657003146 YhfH-like protein; Region: YhfH; pfam14149 645657003147 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 645657003148 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 645657003149 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 645657003150 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 645657003151 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 645657003152 NADH(P)-binding; Region: NAD_binding_10; pfam13460 645657003153 NAD(P) binding site [chemical binding]; other site 645657003154 putative active site [active] 645657003155 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 645657003156 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 645657003157 acyl-activating enzyme (AAE) consensus motif; other site 645657003158 putative AMP binding site [chemical binding]; other site 645657003159 putative active site [active] 645657003160 putative CoA binding site [chemical binding]; other site 645657003161 Peptidase family M48; Region: Peptidase_M48; pfam01435 645657003162 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 645657003163 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 645657003164 active site 645657003165 catalytic residues [active] 645657003166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 645657003167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657003168 Coenzyme A binding pocket [chemical binding]; other site 645657003169 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 645657003170 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 645657003171 putative NADP binding site [chemical binding]; other site 645657003172 putative dimer interface [polypeptide binding]; other site 645657003173 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 645657003174 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 645657003175 siderophore binding site; other site 645657003176 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 645657003177 catalytic core [active] 645657003178 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 645657003179 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 645657003180 dimer interface [polypeptide binding]; other site 645657003181 active site 645657003182 acyl-CoA synthetase; Validated; Region: PRK07638 645657003183 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645657003184 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 645657003185 acyl-activating enzyme (AAE) consensus motif; other site 645657003186 acyl-activating enzyme (AAE) consensus motif; other site 645657003187 AMP binding site [chemical binding]; other site 645657003188 active site 645657003189 CoA binding site [chemical binding]; other site 645657003190 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 645657003191 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 645657003192 heme-binding site [chemical binding]; other site 645657003193 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 645657003194 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 645657003195 dimer interface [polypeptide binding]; other site 645657003196 putative CheW interface [polypeptide binding]; other site 645657003197 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 645657003198 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 645657003199 [2Fe-2S] cluster binding site [ion binding]; other site 645657003200 FAD dependent oxidoreductase; Region: DAO; pfam01266 645657003201 short chain dehydrogenase; Provisional; Region: PRK06701 645657003202 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 645657003203 NAD binding site [chemical binding]; other site 645657003204 metal binding site [ion binding]; metal-binding site 645657003205 active site 645657003206 IDEAL domain; Region: IDEAL; pfam08858 645657003207 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 645657003208 oxidoreductase; Provisional; Region: PRK07985 645657003209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645657003210 NAD(P) binding site [chemical binding]; other site 645657003211 active site 645657003212 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 645657003213 Na binding site [ion binding]; other site 645657003214 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 645657003215 Uncharacterized conserved protein [Function unknown]; Region: COG0398 645657003216 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 645657003217 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 645657003218 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 645657003219 Catalytic site [active] 645657003220 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 645657003221 hypothetical protein; Provisional; Region: PRK08244 645657003222 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 645657003223 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657003224 MarR family; Region: MarR; pfam01047 645657003225 Transposase domain (DUF772); Region: DUF772; pfam05598 645657003226 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 645657003227 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 645657003228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657003229 putative substrate translocation pore; other site 645657003230 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 645657003231 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 645657003232 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 645657003233 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 645657003234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657003235 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 645657003236 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 645657003237 inhibitor-cofactor binding pocket; inhibition site 645657003238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657003239 catalytic residue [active] 645657003240 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645657003241 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645657003242 DNA binding site [nucleotide binding] 645657003243 domain linker motif; other site 645657003244 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 645657003245 putative dimerization interface [polypeptide binding]; other site 645657003246 putative ligand binding site [chemical binding]; other site 645657003247 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 645657003248 Putative ammonia monooxygenase; Region: AmoA; pfam05145 645657003249 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 645657003250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657003251 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657003252 putative substrate translocation pore; other site 645657003253 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 645657003254 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 645657003255 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 645657003256 Transposase domain (DUF772); Region: DUF772; pfam05598 645657003257 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 645657003258 Uncharacterized conserved protein [Function unknown]; Region: COG1633 645657003259 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 645657003260 dinuclear metal binding motif [ion binding]; other site 645657003261 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 645657003262 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 645657003263 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 645657003264 Part of AAA domain; Region: AAA_19; pfam13245 645657003265 Family description; Region: UvrD_C_2; pfam13538 645657003266 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 645657003267 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 645657003268 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 645657003269 active site 645657003270 metal binding site [ion binding]; metal-binding site 645657003271 DNA binding site [nucleotide binding] 645657003272 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 645657003273 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 645657003274 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 645657003275 Walker A/P-loop; other site 645657003276 ATP binding site [chemical binding]; other site 645657003277 Q-loop/lid; other site 645657003278 ABC transporter signature motif; other site 645657003279 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 645657003280 ABC transporter signature motif; other site 645657003281 Walker B; other site 645657003282 D-loop; other site 645657003283 H-loop/switch region; other site 645657003284 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 645657003285 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 645657003286 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 645657003287 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 645657003288 Spore germination protein GerPC; Region: GerPC; pfam10737 645657003289 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 645657003290 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 645657003291 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 645657003292 CotH protein; Region: CotH; pfam08757 645657003293 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 645657003294 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 645657003295 hypothetical protein; Provisional; Region: PRK13673 645657003296 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 645657003297 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 645657003298 active site 645657003299 catalytic triad [active] 645657003300 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 645657003301 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 645657003302 active site 645657003303 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 645657003304 dimer interface [polypeptide binding]; other site 645657003305 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 645657003306 Ligand Binding Site [chemical binding]; other site 645657003307 Molecular Tunnel; other site 645657003308 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 645657003309 substrate binding pocket [chemical binding]; other site 645657003310 aspartate-rich region 2; other site 645657003311 substrate-Mg2+ binding site; other site 645657003312 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 645657003313 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645657003314 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 645657003315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657003316 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645657003317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657003318 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645657003319 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645657003320 DNA binding site [nucleotide binding] 645657003321 domain linker motif; other site 645657003322 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 645657003323 dimerization interface [polypeptide binding]; other site 645657003324 ligand binding site [chemical binding]; other site 645657003325 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 645657003326 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 645657003327 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 645657003328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 645657003329 Lysine efflux permease [General function prediction only]; Region: COG1279 645657003330 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 645657003331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657003332 DNA-binding site [nucleotide binding]; DNA binding site 645657003333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657003334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657003335 homodimer interface [polypeptide binding]; other site 645657003336 catalytic residue [active] 645657003337 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 645657003338 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 645657003339 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 645657003340 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 645657003341 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 645657003342 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 645657003343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657003344 Coenzyme A binding pocket [chemical binding]; other site 645657003345 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 645657003346 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 645657003347 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 645657003348 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 645657003349 FAD binding site [chemical binding]; other site 645657003350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 645657003351 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 645657003352 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 645657003353 S1 domain; Region: S1_2; pfam13509 645657003354 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 645657003355 RNA binding site [nucleotide binding]; other site 645657003356 EDD domain protein, DegV family; Region: DegV; TIGR00762 645657003357 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 645657003358 Uncharacterized conserved protein [Function unknown]; Region: COG1284 645657003359 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645657003360 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645657003361 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 645657003362 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 645657003363 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 645657003364 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 645657003365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657003366 motif II; other site 645657003367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657003368 esterase; Provisional; Region: PRK10566 645657003369 Serine hydrolase (FSH1); Region: FSH1; pfam03959 645657003370 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 645657003371 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 645657003372 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 645657003373 FAD binding domain; Region: FAD_binding_4; pfam01565 645657003374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 645657003375 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 645657003376 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 645657003377 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 645657003378 heterotetramer interface [polypeptide binding]; other site 645657003379 active site pocket [active] 645657003380 cleavage site 645657003381 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 645657003382 nucleotide binding site [chemical binding]; other site 645657003383 N-acetyl-L-glutamate binding site [chemical binding]; other site 645657003384 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 645657003385 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645657003386 inhibitor-cofactor binding pocket; inhibition site 645657003387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657003388 catalytic residue [active] 645657003389 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 645657003390 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 645657003391 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 645657003392 catalytic site [active] 645657003393 subunit interface [polypeptide binding]; other site 645657003394 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 645657003395 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645657003396 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 645657003397 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 645657003398 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645657003399 ATP-grasp domain; Region: ATP-grasp_4; cl17255 645657003400 ornithine carbamoyltransferase; Provisional; Region: PRK00779 645657003401 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 645657003402 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 645657003403 Homeodomain-like domain; Region: HTH_23; pfam13384 645657003404 putative transposase OrfB; Reviewed; Region: PHA02517 645657003405 HTH-like domain; Region: HTH_21; pfam13276 645657003406 Integrase core domain; Region: rve; pfam00665 645657003407 Integrase core domain; Region: rve_3; pfam13683 645657003408 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 645657003409 YjzC-like protein; Region: YjzC; pfam14168 645657003410 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 645657003411 UDP-apiose/xylose synthase; Region: PLN02427 645657003412 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 645657003413 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 645657003414 putative ligand binding site [chemical binding]; other site 645657003415 ComZ; Region: ComZ; pfam10815 645657003416 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 645657003417 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 645657003418 dimer interface [polypeptide binding]; other site 645657003419 active site 645657003420 CoA binding pocket [chemical binding]; other site 645657003421 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 645657003422 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 645657003423 dimer interface [polypeptide binding]; other site 645657003424 active site 645657003425 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 645657003426 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 645657003427 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645657003428 Walker A/P-loop; other site 645657003429 ATP binding site [chemical binding]; other site 645657003430 Q-loop/lid; other site 645657003431 ABC transporter signature motif; other site 645657003432 Walker B; other site 645657003433 D-loop; other site 645657003434 H-loop/switch region; other site 645657003435 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 645657003436 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 645657003437 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645657003438 Walker A/P-loop; other site 645657003439 ATP binding site [chemical binding]; other site 645657003440 Q-loop/lid; other site 645657003441 ABC transporter signature motif; other site 645657003442 Walker B; other site 645657003443 D-loop; other site 645657003444 H-loop/switch region; other site 645657003445 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 645657003446 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 645657003447 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 645657003448 peptide binding site [polypeptide binding]; other site 645657003449 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 645657003450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657003451 dimer interface [polypeptide binding]; other site 645657003452 conserved gate region; other site 645657003453 putative PBP binding loops; other site 645657003454 ABC-ATPase subunit interface; other site 645657003455 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 645657003456 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 645657003457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657003458 dimer interface [polypeptide binding]; other site 645657003459 conserved gate region; other site 645657003460 putative PBP binding loops; other site 645657003461 ABC-ATPase subunit interface; other site 645657003462 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 645657003463 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 645657003464 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 645657003465 active site 645657003466 HIGH motif; other site 645657003467 dimer interface [polypeptide binding]; other site 645657003468 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645657003469 KMSKS motif; other site 645657003470 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 645657003471 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 645657003472 peptide binding site [polypeptide binding]; other site 645657003473 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 645657003474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657003475 dimer interface [polypeptide binding]; other site 645657003476 conserved gate region; other site 645657003477 putative PBP binding loops; other site 645657003478 ABC-ATPase subunit interface; other site 645657003479 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 645657003480 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 645657003481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657003482 dimer interface [polypeptide binding]; other site 645657003483 conserved gate region; other site 645657003484 putative PBP binding loops; other site 645657003485 ABC-ATPase subunit interface; other site 645657003486 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 645657003487 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645657003488 Walker A/P-loop; other site 645657003489 ATP binding site [chemical binding]; other site 645657003490 Q-loop/lid; other site 645657003491 ABC transporter signature motif; other site 645657003492 Walker B; other site 645657003493 D-loop; other site 645657003494 H-loop/switch region; other site 645657003495 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 645657003496 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 645657003497 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645657003498 Walker A/P-loop; other site 645657003499 ATP binding site [chemical binding]; other site 645657003500 Q-loop/lid; other site 645657003501 ABC transporter signature motif; other site 645657003502 Walker B; other site 645657003503 D-loop; other site 645657003504 H-loop/switch region; other site 645657003505 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 645657003506 H+ Antiporter protein; Region: 2A0121; TIGR00900 645657003507 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 645657003508 ArsC family; Region: ArsC; pfam03960 645657003509 putative catalytic residues [active] 645657003510 thiol/disulfide switch; other site 645657003511 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 645657003512 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 645657003513 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 645657003514 oligoendopeptidase F; Region: pepF; TIGR00181 645657003515 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 645657003516 active site 645657003517 Zn binding site [ion binding]; other site 645657003518 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 645657003519 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 645657003520 catalytic residues [active] 645657003521 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 645657003522 apolar tunnel; other site 645657003523 heme binding site [chemical binding]; other site 645657003524 dimerization interface [polypeptide binding]; other site 645657003525 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 645657003526 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 645657003527 N-acetyl-D-glucosamine binding site [chemical binding]; other site 645657003528 catalytic residue [active] 645657003529 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 645657003530 putative active site [active] 645657003531 putative metal binding residues [ion binding]; other site 645657003532 signature motif; other site 645657003533 putative triphosphate binding site [ion binding]; other site 645657003534 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 645657003535 synthetase active site [active] 645657003536 NTP binding site [chemical binding]; other site 645657003537 metal binding site [ion binding]; metal-binding site 645657003538 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 645657003539 ATP-NAD kinase; Region: NAD_kinase; pfam01513 645657003540 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 645657003541 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 645657003542 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 645657003543 active site 645657003544 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 645657003545 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 645657003546 active site 645657003547 metal binding site [ion binding]; metal-binding site 645657003548 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 645657003549 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 645657003550 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 645657003551 TrkA-N domain; Region: TrkA_N; pfam02254 645657003552 TrkA-C domain; Region: TrkA_C; pfam02080 645657003553 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 645657003554 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 645657003555 thiamine phosphate binding site [chemical binding]; other site 645657003556 active site 645657003557 pyrophosphate binding site [ion binding]; other site 645657003558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 645657003559 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 645657003560 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 645657003561 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 645657003562 thiS-thiF/thiG interaction site; other site 645657003563 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 645657003564 ThiS interaction site; other site 645657003565 putative active site [active] 645657003566 tetramer interface [polypeptide binding]; other site 645657003567 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 645657003568 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 645657003569 ATP binding site [chemical binding]; other site 645657003570 substrate interface [chemical binding]; other site 645657003571 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 645657003572 dimer interface [polypeptide binding]; other site 645657003573 substrate binding site [chemical binding]; other site 645657003574 ATP binding site [chemical binding]; other site 645657003575 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 645657003576 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 645657003577 NAD binding site [chemical binding]; other site 645657003578 homotetramer interface [polypeptide binding]; other site 645657003579 homodimer interface [polypeptide binding]; other site 645657003580 substrate binding site [chemical binding]; other site 645657003581 active site 645657003582 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 645657003583 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 645657003584 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 645657003585 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 645657003586 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 645657003587 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 645657003588 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 645657003589 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 645657003590 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 645657003591 Part of AAA domain; Region: AAA_19; pfam13245 645657003592 Family description; Region: UvrD_C_2; pfam13538 645657003593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657003594 Coenzyme A binding pocket [chemical binding]; other site 645657003595 hypothetical protein; Provisional; Region: PRK13679 645657003596 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 645657003597 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 645657003598 Putative esterase; Region: Esterase; pfam00756 645657003599 cystathionine gamma-synthase; Reviewed; Region: PRK08247 645657003600 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 645657003601 homodimer interface [polypeptide binding]; other site 645657003602 substrate-cofactor binding pocket; other site 645657003603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657003604 catalytic residue [active] 645657003605 cystathionine beta-lyase; Provisional; Region: PRK08064 645657003606 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 645657003607 homodimer interface [polypeptide binding]; other site 645657003608 substrate-cofactor binding pocket; other site 645657003609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657003610 catalytic residue [active] 645657003611 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 645657003612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645657003613 Predicted integral membrane protein [Function unknown]; Region: COG5505 645657003614 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645657003615 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645657003616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657003617 non-specific DNA binding site [nucleotide binding]; other site 645657003618 salt bridge; other site 645657003619 sequence-specific DNA binding site [nucleotide binding]; other site 645657003620 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 645657003621 HTH-like domain; Region: HTH_21; pfam13276 645657003622 Integrase core domain; Region: rve; pfam00665 645657003623 Integrase core domain; Region: rve_2; pfam13333 645657003624 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 645657003625 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645657003626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657003627 non-specific DNA binding site [nucleotide binding]; other site 645657003628 salt bridge; other site 645657003629 sequence-specific DNA binding site [nucleotide binding]; other site 645657003630 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 645657003631 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657003632 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657003633 Uncharacterized conserved protein [Function unknown]; Region: COG5444 645657003634 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 645657003635 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 645657003636 RNA polymerase factor sigma-70; Validated; Region: PRK09047 645657003637 Uncharacterized conserved protein [Function unknown]; Region: COG1359 645657003638 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645657003639 HTH domain; Region: HTH_11; pfam08279 645657003640 PRD domain; Region: PRD; pfam00874 645657003641 PRD domain; Region: PRD; pfam00874 645657003642 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645657003643 active site 645657003644 P-loop; other site 645657003645 phosphorylation site [posttranslational modification] 645657003646 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645657003647 active site 645657003648 phosphorylation site [posttranslational modification] 645657003649 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 645657003650 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 645657003651 active site 645657003652 P-loop; other site 645657003653 phosphorylation site [posttranslational modification] 645657003654 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 645657003655 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645657003656 active site 645657003657 phosphorylation site [posttranslational modification] 645657003658 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 645657003659 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 645657003660 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 645657003661 Transposase, Mutator family; Region: Transposase_mut; pfam00872 645657003662 MULE transposase domain; Region: MULE; pfam10551 645657003663 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 645657003664 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 645657003665 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 645657003666 putative deacylase active site [active] 645657003667 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 645657003668 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 645657003669 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 645657003670 UbiA prenyltransferase family; Region: UbiA; pfam01040 645657003671 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 645657003672 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 645657003673 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 645657003674 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 645657003675 NodB motif; other site 645657003676 active site 645657003677 catalytic site [active] 645657003678 Zn binding site [ion binding]; other site 645657003679 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 645657003680 Putative motility protein; Region: YjfB_motility; pfam14070 645657003681 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 645657003682 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 645657003683 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 645657003684 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 645657003685 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 645657003686 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 645657003687 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 645657003688 molybdopterin cofactor binding site; other site 645657003689 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 645657003690 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 645657003691 molybdopterin cofactor binding site; other site 645657003692 Uncharacterized conserved protein [Function unknown]; Region: COG2427 645657003693 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 645657003694 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 645657003695 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 645657003696 nudix motif; other site 645657003697 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 645657003698 Cytochrome P450; Region: p450; cl12078 645657003699 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 645657003700 glycosyltransferase, MGT family; Region: MGT; TIGR01426 645657003701 active site 645657003702 TDP-binding site; other site 645657003703 acceptor substrate-binding pocket; other site 645657003704 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 645657003705 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 645657003706 active site 645657003707 TIGR00245 family protein; Region: TIGR00245 645657003708 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 645657003709 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 645657003710 Walker A/P-loop; other site 645657003711 ATP binding site [chemical binding]; other site 645657003712 Q-loop/lid; other site 645657003713 ABC transporter signature motif; other site 645657003714 Walker B; other site 645657003715 D-loop; other site 645657003716 H-loop/switch region; other site 645657003717 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 645657003718 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 645657003719 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 645657003720 Uncharacterized conserved protein [Function unknown]; Region: COG2427 645657003721 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 645657003722 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645657003723 Glucuronate isomerase; Region: UxaC; pfam02614 645657003724 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 645657003725 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 645657003726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657003727 putative substrate translocation pore; other site 645657003728 Malate/L-lactate dehydrogenase; Region: Ldh_2; pfam02615 645657003729 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 645657003730 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 645657003731 putative NAD(P) binding site [chemical binding]; other site 645657003732 catalytic Zn binding site [ion binding]; other site 645657003733 structural Zn binding site [ion binding]; other site 645657003734 mannonate dehydratase; Provisional; Region: PRK03906 645657003735 mannonate dehydratase; Region: uxuA; TIGR00695 645657003736 D-mannonate oxidoreductase; Provisional; Region: PRK08277 645657003737 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 645657003738 putative NAD(P) binding site [chemical binding]; other site 645657003739 active site 645657003740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657003741 D-galactonate transporter; Region: 2A0114; TIGR00893 645657003742 putative substrate translocation pore; other site 645657003743 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645657003744 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645657003745 DNA binding site [nucleotide binding] 645657003746 domain linker motif; other site 645657003747 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 645657003748 dimerization interface [polypeptide binding]; other site 645657003749 ligand binding site [chemical binding]; other site 645657003750 altronate oxidoreductase; Provisional; Region: PRK03643 645657003751 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 645657003752 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 645657003753 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 645657003754 galactarate dehydratase; Region: galactar-dH20; TIGR03248 645657003755 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 645657003756 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 645657003757 DinB family; Region: DinB; pfam05163 645657003758 DinB superfamily; Region: DinB_2; pfam12867 645657003759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657003760 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645657003761 Walker A motif; other site 645657003762 ATP binding site [chemical binding]; other site 645657003763 Walker B motif; other site 645657003764 arginine finger; other site 645657003765 Homeodomain-like domain; Region: HTH_23; pfam13384 645657003766 putative transposase OrfB; Reviewed; Region: PHA02517 645657003767 HTH-like domain; Region: HTH_21; pfam13276 645657003768 Integrase core domain; Region: rve; pfam00665 645657003769 Integrase core domain; Region: rve_3; pfam13683 645657003770 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 645657003771 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 645657003772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657003773 binding surface 645657003774 TPR motif; other site 645657003775 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657003776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657003777 binding surface 645657003778 TPR motif; other site 645657003779 YCII-related domain; Region: YCII; cl00999 645657003780 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 645657003781 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 645657003782 amidase catalytic site [active] 645657003783 Zn binding residues [ion binding]; other site 645657003784 substrate binding site [chemical binding]; other site 645657003785 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 645657003786 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657003787 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 645657003788 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 645657003789 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 645657003790 pentamer interface [polypeptide binding]; other site 645657003791 dodecaamer interface [polypeptide binding]; other site 645657003792 Phage-related replication protein [General function prediction only]; Region: COG4195 645657003793 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 645657003794 dimanganese center [ion binding]; other site 645657003795 Domain of unknown function (DUF955); Region: DUF955; pfam06114 645657003796 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645657003797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657003798 non-specific DNA binding site [nucleotide binding]; other site 645657003799 salt bridge; other site 645657003800 sequence-specific DNA binding site [nucleotide binding]; other site 645657003801 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 645657003802 putative Zn2+ binding site [ion binding]; other site 645657003803 putative DNA binding site [nucleotide binding]; other site 645657003804 hypothetical protein; Provisional; Region: PRK06921 645657003805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657003806 Walker A motif; other site 645657003807 ATP binding site [chemical binding]; other site 645657003808 Walker B motif; other site 645657003809 positive control sigma-like factor; Validated; Region: PRK06930 645657003810 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657003811 DNA binding residues [nucleotide binding] 645657003812 Phage terminase small subunit; Region: Phage_terminase; pfam10668 645657003813 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 645657003814 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 645657003815 Terminase-like family; Region: Terminase_6; pfam03237 645657003816 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 645657003817 Phage capsid family; Region: Phage_capsid; pfam05065 645657003818 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 645657003819 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 645657003820 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 645657003821 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 645657003822 Phage XkdN-like protein; Region: XkdN; pfam08890 645657003823 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 645657003824 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 645657003825 N-acetyl-D-glucosamine binding site [chemical binding]; other site 645657003826 catalytic residue [active] 645657003827 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 645657003828 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657003829 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 645657003830 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 645657003831 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 645657003832 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 645657003833 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 645657003834 XkdW protein; Region: XkdW; pfam09636 645657003835 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 645657003836 Haemolysin XhlA; Region: XhlA; pfam10779 645657003837 holin, SPP1 family; Region: holin_SPP1; TIGR01592 645657003838 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 645657003839 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 645657003840 amidase catalytic site [active] 645657003841 Zn binding residues [ion binding]; other site 645657003842 substrate binding site [chemical binding]; other site 645657003843 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 645657003844 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657003845 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 645657003846 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 645657003847 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 645657003848 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 645657003849 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 645657003850 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 645657003851 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 645657003852 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 645657003853 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657003854 Zn binding site [ion binding]; other site 645657003855 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 645657003856 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657003857 Zn binding site [ion binding]; other site 645657003858 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 645657003859 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 645657003860 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 645657003861 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 645657003862 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 645657003863 Ligand binding site; other site 645657003864 Putative Catalytic site; other site 645657003865 DXD motif; other site 645657003866 Trypsin; Region: Trypsin; pfam00089 645657003867 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 645657003868 protein binding site [polypeptide binding]; other site 645657003869 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 645657003870 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 645657003871 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 645657003872 SxDxEG motif; other site 645657003873 active site 645657003874 metal binding site [ion binding]; metal-binding site 645657003875 homopentamer interface [polypeptide binding]; other site 645657003876 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 645657003877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657003878 dimer interface [polypeptide binding]; other site 645657003879 conserved gate region; other site 645657003880 putative PBP binding loops; other site 645657003881 ABC-ATPase subunit interface; other site 645657003882 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 645657003883 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 645657003884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657003885 dimer interface [polypeptide binding]; other site 645657003886 conserved gate region; other site 645657003887 putative PBP binding loops; other site 645657003888 ABC-ATPase subunit interface; other site 645657003889 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 645657003890 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645657003891 Walker A/P-loop; other site 645657003892 ATP binding site [chemical binding]; other site 645657003893 Q-loop/lid; other site 645657003894 ABC transporter signature motif; other site 645657003895 Walker B; other site 645657003896 D-loop; other site 645657003897 H-loop/switch region; other site 645657003898 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 645657003899 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 645657003900 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 645657003901 peptide binding site [polypeptide binding]; other site 645657003902 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 645657003903 dimer interface [polypeptide binding]; other site 645657003904 catalytic triad [active] 645657003905 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 645657003906 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 645657003907 active site 645657003908 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645657003909 NlpC/P60 family; Region: NLPC_P60; pfam00877 645657003910 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 645657003911 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645657003912 Walker A/P-loop; other site 645657003913 ATP binding site [chemical binding]; other site 645657003914 Q-loop/lid; other site 645657003915 ABC transporter signature motif; other site 645657003916 Walker B; other site 645657003917 D-loop; other site 645657003918 H-loop/switch region; other site 645657003919 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 645657003920 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 645657003921 Amidinotransferase; Region: Amidinotransf; cl12043 645657003922 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 645657003923 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 645657003924 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 645657003925 heme-binding site [chemical binding]; other site 645657003926 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 645657003927 FAD binding pocket [chemical binding]; other site 645657003928 FAD binding motif [chemical binding]; other site 645657003929 phosphate binding motif [ion binding]; other site 645657003930 beta-alpha-beta structure motif; other site 645657003931 NAD binding pocket [chemical binding]; other site 645657003932 Heme binding pocket [chemical binding]; other site 645657003933 Predicted membrane protein [Function unknown]; Region: COG2323 645657003934 DinB superfamily; Region: DinB_2; pfam12867 645657003935 Protein of unknown function (DUF664); Region: DUF664; pfam04978 645657003936 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 645657003937 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 645657003938 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 645657003939 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 645657003940 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 645657003941 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 645657003942 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 645657003943 putative active site [active] 645657003944 putative substrate binding site [chemical binding]; other site 645657003945 putative cosubstrate binding site; other site 645657003946 catalytic site [active] 645657003947 glutamate 5-kinase; Region: proB; TIGR01027 645657003948 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 645657003949 nucleotide binding site [chemical binding]; other site 645657003950 homotetrameric interface [polypeptide binding]; other site 645657003951 putative phosphate binding site [ion binding]; other site 645657003952 putative allosteric binding site; other site 645657003953 PUA domain; Region: PUA; pfam01472 645657003954 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 645657003955 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 645657003956 putative catalytic cysteine [active] 645657003957 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 645657003958 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645657003959 MarR family; Region: MarR; pfam01047 645657003960 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 645657003961 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 645657003962 nucleoside/Zn binding site; other site 645657003963 dimer interface [polypeptide binding]; other site 645657003964 catalytic motif [active] 645657003965 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 645657003966 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 645657003967 THF binding site; other site 645657003968 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 645657003969 substrate binding site [chemical binding]; other site 645657003970 THF binding site; other site 645657003971 zinc-binding site [ion binding]; other site 645657003972 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 645657003973 active site 645657003974 catalytic residues [active] 645657003975 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 645657003976 Cobalt transport protein; Region: CbiQ; pfam02361 645657003977 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 645657003978 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 645657003979 Walker A/P-loop; other site 645657003980 ATP binding site [chemical binding]; other site 645657003981 Q-loop/lid; other site 645657003982 ABC transporter signature motif; other site 645657003983 Walker B; other site 645657003984 D-loop; other site 645657003985 H-loop/switch region; other site 645657003986 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 645657003987 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 645657003988 Walker A/P-loop; other site 645657003989 ATP binding site [chemical binding]; other site 645657003990 Q-loop/lid; other site 645657003991 ABC transporter signature motif; other site 645657003992 Walker B; other site 645657003993 D-loop; other site 645657003994 H-loop/switch region; other site 645657003995 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 645657003996 YKOF-related Family; Region: Ykof; pfam07615 645657003997 YKOF-related Family; Region: Ykof; pfam07615 645657003998 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645657003999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657004000 active site 645657004001 phosphorylation site [posttranslational modification] 645657004002 intermolecular recognition site; other site 645657004003 dimerization interface [polypeptide binding]; other site 645657004004 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645657004005 DNA binding site [nucleotide binding] 645657004006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645657004007 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645657004008 dimerization interface [polypeptide binding]; other site 645657004009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657004010 dimer interface [polypeptide binding]; other site 645657004011 phosphorylation site [posttranslational modification] 645657004012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657004013 ATP binding site [chemical binding]; other site 645657004014 Mg2+ binding site [ion binding]; other site 645657004015 G-X-G motif; other site 645657004016 Predicted membrane protein [Function unknown]; Region: COG3212 645657004017 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 645657004018 Predicted membrane protein [Function unknown]; Region: COG3212 645657004019 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 645657004020 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 645657004021 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 645657004022 MgtE intracellular N domain; Region: MgtE_N; smart00924 645657004023 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 645657004024 Divalent cation transporter; Region: MgtE; pfam01769 645657004025 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 645657004026 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645657004027 DNA binding residues [nucleotide binding] 645657004028 putative dimer interface [polypeptide binding]; other site 645657004029 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657004030 MarR family; Region: MarR; pfam01047 645657004031 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 645657004032 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 645657004033 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 645657004034 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 645657004035 putative active site [active] 645657004036 putative metal binding site [ion binding]; other site 645657004037 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 645657004038 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 645657004039 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 645657004040 Ligand binding site; other site 645657004041 Putative Catalytic site; other site 645657004042 DXD motif; other site 645657004043 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 645657004044 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 645657004045 DNA binding site [nucleotide binding] 645657004046 active site 645657004047 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 645657004048 nucleotide binding site [chemical binding]; other site 645657004049 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 645657004050 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 645657004051 putative DNA binding site [nucleotide binding]; other site 645657004052 putative homodimer interface [polypeptide binding]; other site 645657004053 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 645657004054 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 645657004055 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 645657004056 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 645657004057 PAS domain; Region: PAS_9; pfam13426 645657004058 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645657004059 metal binding site [ion binding]; metal-binding site 645657004060 active site 645657004061 I-site; other site 645657004062 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645657004063 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 645657004064 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 645657004065 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 645657004066 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 645657004067 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657004068 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 645657004069 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 645657004070 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 645657004071 heat shock protein HtpX; Provisional; Region: PRK05457 645657004072 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 645657004073 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 645657004074 Transposase domain (DUF772); Region: DUF772; pfam05598 645657004075 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 645657004076 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 645657004077 Acyltransferase family; Region: Acyl_transf_3; pfam01757 645657004078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657004079 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 645657004080 putative active site [active] 645657004081 heme pocket [chemical binding]; other site 645657004082 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 645657004083 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 645657004084 putative active site [active] 645657004085 heme pocket [chemical binding]; other site 645657004086 PAS domain; Region: PAS; smart00091 645657004087 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 645657004088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657004089 putative active site [active] 645657004090 heme pocket [chemical binding]; other site 645657004091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657004092 dimer interface [polypeptide binding]; other site 645657004093 phosphorylation site [posttranslational modification] 645657004094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657004095 ATP binding site [chemical binding]; other site 645657004096 Mg2+ binding site [ion binding]; other site 645657004097 G-X-G motif; other site 645657004098 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 645657004099 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 645657004100 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 645657004101 DNA binding site [nucleotide binding] 645657004102 active site 645657004103 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 645657004104 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 645657004105 Predicted kinase [General function prediction only]; Region: COG4857 645657004106 Phosphotransferase enzyme family; Region: APH; pfam01636 645657004107 Predicted amidohydrolase [General function prediction only]; Region: COG0388 645657004108 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 645657004109 putative active site [active] 645657004110 catalytic triad [active] 645657004111 putative dimer interface [polypeptide binding]; other site 645657004112 transaminase; Reviewed; Region: PRK08068 645657004113 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657004114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657004115 homodimer interface [polypeptide binding]; other site 645657004116 catalytic residue [active] 645657004117 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 645657004118 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 645657004119 dimer interface [polypeptide binding]; other site 645657004120 active site 645657004121 catalytic residue [active] 645657004122 metal binding site [ion binding]; metal-binding site 645657004123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657004124 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 645657004125 motif II; other site 645657004126 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 645657004127 intersubunit interface [polypeptide binding]; other site 645657004128 active site 645657004129 Zn2+ binding site [ion binding]; other site 645657004130 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 645657004131 Cupin domain; Region: Cupin_2; pfam07883 645657004132 Uncharacterized conserved protein [Function unknown]; Region: COG3339 645657004133 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 645657004134 Cache domain; Region: Cache_1; pfam02743 645657004135 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 645657004136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657004137 dimer interface [polypeptide binding]; other site 645657004138 phosphorylation site [posttranslational modification] 645657004139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657004140 ATP binding site [chemical binding]; other site 645657004141 Mg2+ binding site [ion binding]; other site 645657004142 G-X-G motif; other site 645657004143 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657004144 MarR family; Region: MarR; pfam01047 645657004145 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 645657004146 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 645657004147 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 645657004148 ligand binding site [chemical binding]; other site 645657004149 flagellar motor protein MotA; Validated; Region: PRK08124 645657004150 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 645657004151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657004152 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645657004153 Walker A motif; other site 645657004154 ATP binding site [chemical binding]; other site 645657004155 Walker B motif; other site 645657004156 arginine finger; other site 645657004157 UvrB/uvrC motif; Region: UVR; pfam02151 645657004158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657004159 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645657004160 Walker A motif; other site 645657004161 ATP binding site [chemical binding]; other site 645657004162 Walker B motif; other site 645657004163 arginine finger; other site 645657004164 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 645657004165 Uncharacterized membrane protein [Function unknown]; Region: COG3949 645657004166 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 645657004167 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 645657004168 Ligand Binding Site [chemical binding]; other site 645657004169 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 645657004170 active site 645657004171 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 645657004172 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 645657004173 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 645657004174 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 645657004175 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 645657004176 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 645657004177 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 645657004178 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 645657004179 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 645657004180 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 645657004181 catalytic residues [active] 645657004182 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 645657004183 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645657004184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657004185 motif II; other site 645657004186 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 645657004187 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 645657004188 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 645657004189 active site 645657004190 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645657004191 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645657004192 DNA binding site [nucleotide binding] 645657004193 domain linker motif; other site 645657004194 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 645657004195 putative dimerization interface [polypeptide binding]; other site 645657004196 putative ligand binding site [chemical binding]; other site 645657004197 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645657004198 CAT RNA binding domain; Region: CAT_RBD; pfam03123 645657004199 PRD domain; Region: PRD; pfam00874 645657004200 PRD domain; Region: PRD; pfam00874 645657004201 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645657004202 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 645657004203 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645657004204 active site turn [active] 645657004205 phosphorylation site [posttranslational modification] 645657004206 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 645657004207 HPr interaction site; other site 645657004208 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645657004209 active site 645657004210 phosphorylation site [posttranslational modification] 645657004211 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 645657004212 dimerization domain swap beta strand [polypeptide binding]; other site 645657004213 regulatory protein interface [polypeptide binding]; other site 645657004214 active site 645657004215 regulatory phosphorylation site [posttranslational modification]; other site 645657004216 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 645657004217 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 645657004218 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 645657004219 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 645657004220 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 645657004221 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 645657004222 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645657004223 FeS/SAM binding site; other site 645657004224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657004225 Coenzyme A binding pocket [chemical binding]; other site 645657004226 Cache domain; Region: Cache_1; pfam02743 645657004227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645657004228 dimerization interface [polypeptide binding]; other site 645657004229 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 645657004230 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 645657004231 dimer interface [polypeptide binding]; other site 645657004232 putative CheW interface [polypeptide binding]; other site 645657004233 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 645657004234 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 645657004235 Transposase, Mutator family; Region: Transposase_mut; pfam00872 645657004236 MULE transposase domain; Region: MULE; pfam10551 645657004237 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 645657004238 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 645657004239 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 645657004240 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 645657004241 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 645657004242 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645657004243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657004244 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 645657004245 putative active site [active] 645657004246 heme pocket [chemical binding]; other site 645657004247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657004248 putative active site [active] 645657004249 heme pocket [chemical binding]; other site 645657004250 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 645657004251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657004252 putative active site [active] 645657004253 heme pocket [chemical binding]; other site 645657004254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657004255 dimer interface [polypeptide binding]; other site 645657004256 phosphorylation site [posttranslational modification] 645657004257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657004258 ATP binding site [chemical binding]; other site 645657004259 Mg2+ binding site [ion binding]; other site 645657004260 G-X-G motif; other site 645657004261 aminotransferase A; Validated; Region: PRK07683 645657004262 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657004263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657004264 homodimer interface [polypeptide binding]; other site 645657004265 catalytic residue [active] 645657004266 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 645657004267 putative CheA interaction surface; other site 645657004268 Response regulator receiver domain; Region: Response_reg; pfam00072 645657004269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657004270 active site 645657004271 phosphorylation site [posttranslational modification] 645657004272 intermolecular recognition site; other site 645657004273 dimerization interface [polypeptide binding]; other site 645657004274 YkyB-like protein; Region: YkyB; pfam14177 645657004275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657004276 H+ Antiporter protein; Region: 2A0121; TIGR00900 645657004277 putative substrate translocation pore; other site 645657004278 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657004279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 645657004280 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 645657004281 phosphodiesterase YaeI; Provisional; Region: PRK11340 645657004282 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 645657004283 putative active site [active] 645657004284 putative metal binding site [ion binding]; other site 645657004285 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 645657004286 short chain dehydrogenase; Provisional; Region: PRK07677 645657004287 NAD(P) binding site [chemical binding]; other site 645657004288 substrate binding site [chemical binding]; other site 645657004289 homotetramer interface [polypeptide binding]; other site 645657004290 active site 645657004291 homodimer interface [polypeptide binding]; other site 645657004292 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645657004293 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 645657004294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 645657004295 Protein of unknown function (DUF458); Region: DUF458; pfam04308 645657004296 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 645657004297 FOG: CBS domain [General function prediction only]; Region: COG0517 645657004298 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 645657004299 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657004300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657004301 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 645657004302 dimerization interface [polypeptide binding]; other site 645657004303 flavodoxin; Provisional; Region: PRK06703 645657004304 BNR repeat-like domain; Region: BNR_2; pfam13088 645657004305 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 645657004306 flavodoxin, short chain; Region: flav_short; TIGR01753 645657004307 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 645657004308 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 645657004309 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 645657004310 active site 645657004311 trimer interface [polypeptide binding]; other site 645657004312 substrate binding site [chemical binding]; other site 645657004313 CoA binding site [chemical binding]; other site 645657004314 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645657004315 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 645657004316 metal binding site [ion binding]; metal-binding site 645657004317 putative dimer interface [polypeptide binding]; other site 645657004318 hypothetical protein; Provisional; Region: PRK03094 645657004319 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 645657004320 Mechanosensitive ion channel; Region: MS_channel; pfam00924 645657004321 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 645657004322 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 645657004323 dimer interface [polypeptide binding]; other site 645657004324 decamer (pentamer of dimers) interface [polypeptide binding]; other site 645657004325 catalytic triad [active] 645657004326 peroxidatic and resolving cysteines [active] 645657004327 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 645657004328 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 645657004329 catalytic residues [active] 645657004330 Integrase core domain; Region: rve_2; pfam13333 645657004331 Homeodomain-like domain; Region: HTH_23; pfam13384 645657004332 HTH-like domain; Region: HTH_21; pfam13276 645657004333 Integrase core domain; Region: rve; pfam00665 645657004334 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 645657004335 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 645657004336 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 645657004337 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 645657004338 GTP binding site; other site 645657004339 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 645657004340 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 645657004341 ATP binding site [chemical binding]; other site 645657004342 substrate interface [chemical binding]; other site 645657004343 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 645657004344 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 645657004345 dimer interface [polypeptide binding]; other site 645657004346 putative functional site; other site 645657004347 putative MPT binding site; other site 645657004348 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 645657004349 Walker A motif; other site 645657004350 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 645657004351 MoaE homodimer interface [polypeptide binding]; other site 645657004352 MoaD interaction [polypeptide binding]; other site 645657004353 active site residues [active] 645657004354 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 645657004355 MoaE interaction surface [polypeptide binding]; other site 645657004356 MoeB interaction surface [polypeptide binding]; other site 645657004357 thiocarboxylated glycine; other site 645657004358 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645657004359 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645657004360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657004361 Walker A/P-loop; other site 645657004362 ATP binding site [chemical binding]; other site 645657004363 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645657004364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657004365 Q-loop/lid; other site 645657004366 ABC transporter signature motif; other site 645657004367 Walker B; other site 645657004368 D-loop; other site 645657004369 H-loop/switch region; other site 645657004370 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645657004371 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645657004372 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 645657004373 Walker A/P-loop; other site 645657004374 ATP binding site [chemical binding]; other site 645657004375 Q-loop/lid; other site 645657004376 ABC transporter signature motif; other site 645657004377 Walker B; other site 645657004378 D-loop; other site 645657004379 H-loop/switch region; other site 645657004380 Yip1 domain; Region: Yip1; pfam04893 645657004381 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 645657004382 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 645657004383 HlyD family secretion protein; Region: HlyD_3; pfam13437 645657004384 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645657004385 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645657004386 Walker A/P-loop; other site 645657004387 ATP binding site [chemical binding]; other site 645657004388 Q-loop/lid; other site 645657004389 ABC transporter signature motif; other site 645657004390 Walker B; other site 645657004391 D-loop; other site 645657004392 H-loop/switch region; other site 645657004393 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645657004394 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645657004395 FtsX-like permease family; Region: FtsX; pfam02687 645657004396 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 645657004397 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 645657004398 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 645657004399 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 645657004400 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 645657004401 putative substrate binding site [chemical binding]; other site 645657004402 putative ATP binding site [chemical binding]; other site 645657004403 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 645657004404 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645657004405 active site 645657004406 phosphorylation site [posttranslational modification] 645657004407 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 645657004408 active site 645657004409 P-loop; other site 645657004410 phosphorylation site [posttranslational modification] 645657004411 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 645657004412 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 645657004413 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 645657004414 Catalytic site [active] 645657004415 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 645657004416 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657004417 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657004418 ABC transporter; Region: ABC_tran_2; pfam12848 645657004419 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657004420 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 645657004421 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645657004422 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 645657004423 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 645657004424 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 645657004425 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 645657004426 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 645657004427 rod-share determining protein MreBH; Provisional; Region: PRK13929 645657004428 MreB and similar proteins; Region: MreB_like; cd10225 645657004429 nucleotide binding site [chemical binding]; other site 645657004430 Mg binding site [ion binding]; other site 645657004431 putative protofilament interaction site [polypeptide binding]; other site 645657004432 RodZ interaction site [polypeptide binding]; other site 645657004433 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 645657004434 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 645657004435 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 645657004436 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657004437 putative active site [active] 645657004438 heme pocket [chemical binding]; other site 645657004439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657004440 dimer interface [polypeptide binding]; other site 645657004441 phosphorylation site [posttranslational modification] 645657004442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657004443 ATP binding site [chemical binding]; other site 645657004444 Mg2+ binding site [ion binding]; other site 645657004445 G-X-G motif; other site 645657004446 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 645657004447 putative active site pocket [active] 645657004448 dimerization interface [polypeptide binding]; other site 645657004449 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 645657004450 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 645657004451 putative active site pocket [active] 645657004452 dimerization interface [polypeptide binding]; other site 645657004453 putative catalytic residue [active] 645657004454 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 645657004455 TrkA-N domain; Region: TrkA_N; pfam02254 645657004456 TrkA-C domain; Region: TrkA_C; pfam02080 645657004457 adenine deaminase; Region: ade; TIGR01178 645657004458 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645657004459 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 645657004460 active site 645657004461 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 645657004462 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 645657004463 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 645657004464 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 645657004465 hypothetical protein; Provisional; Region: PRK13667 645657004466 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 645657004467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657004468 active site 645657004469 motif I; other site 645657004470 motif II; other site 645657004471 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657004472 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 645657004473 active site 645657004474 catalytic residues [active] 645657004475 metal binding site [ion binding]; metal-binding site 645657004476 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 645657004477 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 645657004478 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 645657004479 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 645657004480 TPP-binding site [chemical binding]; other site 645657004481 tetramer interface [polypeptide binding]; other site 645657004482 heterodimer interface [polypeptide binding]; other site 645657004483 phosphorylation loop region [posttranslational modification] 645657004484 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 645657004485 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 645657004486 alpha subunit interface [polypeptide binding]; other site 645657004487 TPP binding site [chemical binding]; other site 645657004488 heterodimer interface [polypeptide binding]; other site 645657004489 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 645657004490 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 645657004491 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 645657004492 E3 interaction surface; other site 645657004493 lipoyl attachment site [posttranslational modification]; other site 645657004494 e3 binding domain; Region: E3_binding; pfam02817 645657004495 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 645657004496 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 645657004497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 645657004498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645657004499 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 645657004500 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 645657004501 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 645657004502 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 645657004503 homodimer interface [polypeptide binding]; other site 645657004504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657004505 catalytic residue [active] 645657004506 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 645657004507 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 645657004508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 645657004509 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 645657004510 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 645657004511 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 645657004512 active site 645657004513 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 645657004514 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 645657004515 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 645657004516 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 645657004517 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 645657004518 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 645657004519 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 645657004520 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 645657004521 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 645657004522 active site 645657004523 Zn binding site [ion binding]; other site 645657004524 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657004525 DNA binding residues [nucleotide binding] 645657004526 Putative zinc-finger; Region: zf-HC2; pfam13490 645657004527 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 645657004528 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 645657004529 G1 box; other site 645657004530 putative GEF interaction site [polypeptide binding]; other site 645657004531 GTP/Mg2+ binding site [chemical binding]; other site 645657004532 Switch I region; other site 645657004533 G2 box; other site 645657004534 G3 box; other site 645657004535 Switch II region; other site 645657004536 G4 box; other site 645657004537 G5 box; other site 645657004538 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 645657004539 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 645657004540 YlaH-like protein; Region: YlaH; pfam14036 645657004541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 645657004542 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 645657004543 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 645657004544 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 645657004545 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 645657004546 putative active site [active] 645657004547 PhoH-like protein; Region: PhoH; pfam02562 645657004548 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 645657004549 glutaminase A; Region: Gln_ase; TIGR03814 645657004550 hypothetical protein; Provisional; Region: PRK13666 645657004551 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 645657004552 pyruvate carboxylase; Reviewed; Region: PRK12999 645657004553 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645657004554 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 645657004555 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 645657004556 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 645657004557 active site 645657004558 catalytic residues [active] 645657004559 metal binding site [ion binding]; metal-binding site 645657004560 homodimer binding site [polypeptide binding]; other site 645657004561 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 645657004562 carboxyltransferase (CT) interaction site; other site 645657004563 biotinylation site [posttranslational modification]; other site 645657004564 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 645657004565 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 645657004566 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 645657004567 UbiA prenyltransferase family; Region: UbiA; pfam01040 645657004568 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 645657004569 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 645657004570 Cytochrome c; Region: Cytochrom_C; pfam00034 645657004571 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 645657004572 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 645657004573 D-pathway; other site 645657004574 Putative ubiquinol binding site [chemical binding]; other site 645657004575 Low-spin heme (heme b) binding site [chemical binding]; other site 645657004576 Putative water exit pathway; other site 645657004577 Binuclear center (heme o3/CuB) [ion binding]; other site 645657004578 K-pathway; other site 645657004579 Putative proton exit pathway; other site 645657004580 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 645657004581 Subunit I/III interface [polypeptide binding]; other site 645657004582 Subunit III/IV interface [polypeptide binding]; other site 645657004583 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 645657004584 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 645657004585 YugN-like family; Region: YugN; pfam08868 645657004586 FOG: CBS domain [General function prediction only]; Region: COG0517 645657004587 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 645657004588 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 645657004589 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 645657004590 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 645657004591 Putative coat protein; Region: YlbD_coat; pfam14071 645657004592 YlbE-like protein; Region: YlbE; pfam14003 645657004593 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 645657004594 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 645657004595 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 645657004596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657004597 S-adenosylmethionine binding site [chemical binding]; other site 645657004598 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 645657004599 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 645657004600 active site 645657004601 (T/H)XGH motif; other site 645657004602 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 645657004603 Nucleoside recognition; Region: Gate; pfam07670 645657004604 Nucleoside recognition; Region: Gate; pfam07670 645657004605 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 645657004606 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 645657004607 nucleophile elbow; other site 645657004608 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 645657004609 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 645657004610 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 645657004611 protein binding site [polypeptide binding]; other site 645657004612 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 645657004613 hypothetical protein; Provisional; Region: PRK13670 645657004614 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 645657004615 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 645657004616 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 645657004617 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 645657004618 hypothetical protein; Provisional; Region: PRK13688 645657004619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657004620 Coenzyme A binding pocket [chemical binding]; other site 645657004621 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 645657004622 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 645657004623 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 645657004624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 645657004625 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 645657004626 mraZ protein; Region: TIGR00242 645657004627 MraZ protein; Region: MraZ; pfam02381 645657004628 MraZ protein; Region: MraZ; pfam02381 645657004629 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 645657004630 MraW methylase family; Region: Methyltransf_5; pfam01795 645657004631 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 645657004632 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 645657004633 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 645657004634 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645657004635 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 645657004636 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 645657004637 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 645657004638 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 645657004639 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645657004640 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 645657004641 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 645657004642 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 645657004643 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645657004644 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645657004645 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 645657004646 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 645657004647 Mg++ binding site [ion binding]; other site 645657004648 putative catalytic motif [active] 645657004649 putative substrate binding site [chemical binding]; other site 645657004650 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 645657004651 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645657004652 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645657004653 stage V sporulation protein E; Region: spoVE; TIGR02615 645657004654 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 645657004655 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 645657004656 active site 645657004657 homodimer interface [polypeptide binding]; other site 645657004658 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 645657004659 FAD binding domain; Region: FAD_binding_4; pfam01565 645657004660 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 645657004661 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 645657004662 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 645657004663 Cell division protein FtsQ; Region: FtsQ; pfam03799 645657004664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 645657004665 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 645657004666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 645657004667 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 645657004668 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 645657004669 cell division protein FtsA; Region: ftsA; TIGR01174 645657004670 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645657004671 nucleotide binding site [chemical binding]; other site 645657004672 Cell division protein FtsA; Region: FtsA; pfam14450 645657004673 cell division protein FtsZ; Validated; Region: PRK09330 645657004674 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 645657004675 nucleotide binding site [chemical binding]; other site 645657004676 SulA interaction site; other site 645657004677 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 645657004678 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 645657004679 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 645657004680 active site 645657004681 catalytic triad [active] 645657004682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 645657004683 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 645657004684 Cna protein B-type domain; Region: Cna_B_2; pfam13715 645657004685 Cna protein B-type domain; Region: Cna_B_2; pfam13715 645657004686 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 645657004687 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 645657004688 sporulation sigma factor SigE; Reviewed; Region: PRK08301 645657004689 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657004690 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657004691 DNA binding residues [nucleotide binding] 645657004692 sporulation sigma factor SigG; Reviewed; Region: PRK08215 645657004693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657004694 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 645657004695 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657004696 DNA binding residues [nucleotide binding] 645657004697 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 645657004698 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 645657004699 Walker A/P-loop; other site 645657004700 ATP binding site [chemical binding]; other site 645657004701 Q-loop/lid; other site 645657004702 ABC transporter signature motif; other site 645657004703 Walker B; other site 645657004704 D-loop; other site 645657004705 H-loop/switch region; other site 645657004706 acetylornithine deacetylase; Validated; Region: PRK08596 645657004707 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 645657004708 metal binding site [ion binding]; metal-binding site 645657004709 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 645657004710 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 645657004711 uncharacterized protein, YfiH family; Region: TIGR00726 645657004712 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 645657004713 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645657004714 catalytic residue [active] 645657004715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 645657004716 YGGT family; Region: YGGT; pfam02325 645657004717 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 645657004718 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645657004719 RNA binding surface [nucleotide binding]; other site 645657004720 DivIVA protein; Region: DivIVA; pfam05103 645657004721 DivIVA domain; Region: DivI1A_domain; TIGR03544 645657004722 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 645657004723 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 645657004724 HIGH motif; other site 645657004725 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 645657004726 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 645657004727 active site 645657004728 KMSKS motif; other site 645657004729 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 645657004730 tRNA binding surface [nucleotide binding]; other site 645657004731 anticodon binding site; other site 645657004732 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 645657004733 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 645657004734 lipoprotein signal peptidase; Provisional; Region: PRK14787 645657004735 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 645657004736 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645657004737 RNA binding surface [nucleotide binding]; other site 645657004738 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 645657004739 active site 645657004740 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 645657004741 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645657004742 active site 645657004743 uracil-xanthine permease; Region: ncs2; TIGR00801 645657004744 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 645657004745 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 645657004746 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 645657004747 dihydroorotase; Validated; Region: pyrC; PRK09357 645657004748 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 645657004749 active site 645657004750 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 645657004751 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 645657004752 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 645657004753 catalytic site [active] 645657004754 subunit interface [polypeptide binding]; other site 645657004755 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 645657004756 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645657004757 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 645657004758 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 645657004759 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645657004760 ATP-grasp domain; Region: ATP-grasp_4; cl17255 645657004761 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 645657004762 IMP binding site; other site 645657004763 dimer interface [polypeptide binding]; other site 645657004764 interdomain contacts; other site 645657004765 partial ornithine binding site; other site 645657004766 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 645657004767 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 645657004768 FAD binding pocket [chemical binding]; other site 645657004769 FAD binding motif [chemical binding]; other site 645657004770 phosphate binding motif [ion binding]; other site 645657004771 beta-alpha-beta structure motif; other site 645657004772 NAD binding pocket [chemical binding]; other site 645657004773 Iron coordination center [ion binding]; other site 645657004774 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 645657004775 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 645657004776 heterodimer interface [polypeptide binding]; other site 645657004777 active site 645657004778 FMN binding site [chemical binding]; other site 645657004779 homodimer interface [polypeptide binding]; other site 645657004780 substrate binding site [chemical binding]; other site 645657004781 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 645657004782 active site 645657004783 dimer interface [polypeptide binding]; other site 645657004784 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645657004785 active site 645657004786 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 645657004787 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 645657004788 Active Sites [active] 645657004789 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 645657004790 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 645657004791 ATP-sulfurylase; Region: ATPS; cd00517 645657004792 active site 645657004793 HXXH motif; other site 645657004794 flexible loop; other site 645657004795 AAA domain; Region: AAA_33; pfam13671 645657004796 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 645657004797 ligand-binding site [chemical binding]; other site 645657004798 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 645657004799 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 645657004800 active site 645657004801 SAM binding site [chemical binding]; other site 645657004802 homodimer interface [polypeptide binding]; other site 645657004803 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 645657004804 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 645657004805 putative active site [active] 645657004806 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 645657004807 putative active site [active] 645657004808 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 645657004809 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 645657004810 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 645657004811 Domain of unknown function (DUF814); Region: DUF814; pfam05670 645657004812 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 645657004813 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 645657004814 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645657004815 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 645657004816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657004817 motif II; other site 645657004818 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 645657004819 TIGR00255 family protein; Region: TIGR00255 645657004820 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 645657004821 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 645657004822 hypothetical protein; Provisional; Region: PRK04323 645657004823 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 645657004824 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 645657004825 catalytic site [active] 645657004826 G-X2-G-X-G-K; other site 645657004827 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 645657004828 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 645657004829 Flavoprotein; Region: Flavoprotein; pfam02441 645657004830 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 645657004831 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 645657004832 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645657004833 ATP binding site [chemical binding]; other site 645657004834 putative Mg++ binding site [ion binding]; other site 645657004835 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657004836 nucleotide binding region [chemical binding]; other site 645657004837 ATP-binding site [chemical binding]; other site 645657004838 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 645657004839 active site 645657004840 catalytic residues [active] 645657004841 metal binding site [ion binding]; metal-binding site 645657004842 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 645657004843 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 645657004844 putative active site [active] 645657004845 substrate binding site [chemical binding]; other site 645657004846 putative cosubstrate binding site; other site 645657004847 catalytic site [active] 645657004848 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 645657004849 substrate binding site [chemical binding]; other site 645657004850 16S rRNA methyltransferase B; Provisional; Region: PRK14902 645657004851 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 645657004852 putative RNA binding site [nucleotide binding]; other site 645657004853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657004854 S-adenosylmethionine binding site [chemical binding]; other site 645657004855 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 645657004856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645657004857 FeS/SAM binding site; other site 645657004858 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 645657004859 Protein phosphatase 2C; Region: PP2C; pfam00481 645657004860 active site 645657004861 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 645657004862 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 645657004863 active site 645657004864 ATP binding site [chemical binding]; other site 645657004865 substrate binding site [chemical binding]; other site 645657004866 activation loop (A-loop); other site 645657004867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 645657004868 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 645657004869 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 645657004870 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 645657004871 GTPase RsgA; Reviewed; Region: PRK00098 645657004872 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 645657004873 RNA binding site [nucleotide binding]; other site 645657004874 homodimer interface [polypeptide binding]; other site 645657004875 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 645657004876 GTPase/Zn-binding domain interface [polypeptide binding]; other site 645657004877 GTP/Mg2+ binding site [chemical binding]; other site 645657004878 G4 box; other site 645657004879 G5 box; other site 645657004880 G1 box; other site 645657004881 Switch I region; other site 645657004882 G2 box; other site 645657004883 G3 box; other site 645657004884 Switch II region; other site 645657004885 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 645657004886 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 645657004887 substrate binding site [chemical binding]; other site 645657004888 hexamer interface [polypeptide binding]; other site 645657004889 metal binding site [ion binding]; metal-binding site 645657004890 Thiamine pyrophosphokinase; Region: TPK; cd07995 645657004891 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 645657004892 active site 645657004893 dimerization interface [polypeptide binding]; other site 645657004894 thiamine binding site [chemical binding]; other site 645657004895 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 645657004896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 645657004897 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 645657004898 DAK2 domain; Region: Dak2; pfam02734 645657004899 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 645657004900 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 645657004901 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 645657004902 putative L-serine binding site [chemical binding]; other site 645657004903 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Region: sda_alpha; TIGR00718 645657004904 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 645657004905 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 645657004906 Pathogenicity locus; Region: Cdd1; pfam11731 645657004907 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 645657004908 generic binding surface II; other site 645657004909 ssDNA binding site; other site 645657004910 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645657004911 ATP binding site [chemical binding]; other site 645657004912 putative Mg++ binding site [ion binding]; other site 645657004913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657004914 nucleotide binding region [chemical binding]; other site 645657004915 ATP-binding site [chemical binding]; other site 645657004916 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 645657004917 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 645657004918 putative phosphate acyltransferase; Provisional; Region: PRK05331 645657004919 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 645657004920 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 645657004921 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 645657004922 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 645657004923 NAD(P) binding site [chemical binding]; other site 645657004924 homotetramer interface [polypeptide binding]; other site 645657004925 homodimer interface [polypeptide binding]; other site 645657004926 active site 645657004927 acyl carrier protein; Provisional; Region: acpP; PRK00982 645657004928 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 645657004929 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 645657004930 dimerization interface [polypeptide binding]; other site 645657004931 active site 645657004932 metal binding site [ion binding]; metal-binding site 645657004933 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 645657004934 dsRNA binding site [nucleotide binding]; other site 645657004935 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 645657004936 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 645657004937 Walker A/P-loop; other site 645657004938 ATP binding site [chemical binding]; other site 645657004939 Q-loop/lid; other site 645657004940 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 645657004941 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 645657004942 ABC transporter signature motif; other site 645657004943 Walker B; other site 645657004944 D-loop; other site 645657004945 H-loop/switch region; other site 645657004946 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 645657004947 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 645657004948 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 645657004949 GTP binding site [chemical binding]; other site 645657004950 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 645657004951 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 645657004952 putative DNA-binding protein; Validated; Region: PRK00118 645657004953 signal recognition particle protein; Provisional; Region: PRK10867 645657004954 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 645657004955 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 645657004956 P loop; other site 645657004957 GTP binding site [chemical binding]; other site 645657004958 Signal peptide binding domain; Region: SRP_SPB; pfam02978 645657004959 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 645657004960 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 645657004961 KH domain; Region: KH_4; pfam13083 645657004962 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 645657004963 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 645657004964 RimM N-terminal domain; Region: RimM; pfam01782 645657004965 PRC-barrel domain; Region: PRC; pfam05239 645657004966 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 645657004967 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 645657004968 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 645657004969 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 645657004970 GTP/Mg2+ binding site [chemical binding]; other site 645657004971 G4 box; other site 645657004972 G5 box; other site 645657004973 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 645657004974 G1 box; other site 645657004975 G1 box; other site 645657004976 GTP/Mg2+ binding site [chemical binding]; other site 645657004977 Switch I region; other site 645657004978 G2 box; other site 645657004979 G2 box; other site 645657004980 G3 box; other site 645657004981 G3 box; other site 645657004982 Switch II region; other site 645657004983 Switch II region; other site 645657004984 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 645657004985 RNA/DNA hybrid binding site [nucleotide binding]; other site 645657004986 active site 645657004987 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 645657004988 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 645657004989 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 645657004990 CoA-ligase; Region: Ligase_CoA; pfam00549 645657004991 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 645657004992 CoA binding domain; Region: CoA_binding; smart00881 645657004993 CoA-ligase; Region: Ligase_CoA; pfam00549 645657004994 DNA protecting protein DprA; Region: dprA; TIGR00732 645657004995 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 645657004996 DNA topoisomerase I; Validated; Region: PRK05582 645657004997 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 645657004998 active site 645657004999 interdomain interaction site; other site 645657005000 putative metal-binding site [ion binding]; other site 645657005001 nucleotide binding site [chemical binding]; other site 645657005002 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 645657005003 domain I; other site 645657005004 DNA binding groove [nucleotide binding] 645657005005 phosphate binding site [ion binding]; other site 645657005006 domain II; other site 645657005007 domain III; other site 645657005008 nucleotide binding site [chemical binding]; other site 645657005009 catalytic site [active] 645657005010 domain IV; other site 645657005011 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 645657005012 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 645657005013 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 645657005014 Glucose inhibited division protein A; Region: GIDA; pfam01134 645657005015 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 645657005016 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 645657005017 active site 645657005018 Int/Topo IB signature motif; other site 645657005019 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 645657005020 active site 645657005021 HslU subunit interaction site [polypeptide binding]; other site 645657005022 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 645657005023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657005024 Walker A motif; other site 645657005025 ATP binding site [chemical binding]; other site 645657005026 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 645657005027 Walker B motif; other site 645657005028 arginine finger; other site 645657005029 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 645657005030 transcriptional repressor CodY; Validated; Region: PRK04158 645657005031 CodY GAF-like domain; Region: CodY; pfam06018 645657005032 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 645657005033 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 645657005034 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 645657005035 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 645657005036 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 645657005037 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 645657005038 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 645657005039 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 645657005040 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 645657005041 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 645657005042 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 645657005043 flagellar motor switch protein FliG; Region: fliG; TIGR00207 645657005044 MgtE intracellular N domain; Region: MgtE_N; smart00924 645657005045 FliG C-terminal domain; Region: FliG_C; pfam01706 645657005046 flagellar assembly protein H; Validated; Region: fliH; PRK06669 645657005047 Flagellar assembly protein FliH; Region: FliH; pfam02108 645657005048 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 645657005049 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 645657005050 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 645657005051 Walker A motif/ATP binding site; other site 645657005052 Walker B motif; other site 645657005053 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 645657005054 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 645657005055 Uncharacterized conserved protein [Function unknown]; Region: COG3334 645657005056 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 645657005057 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 645657005058 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 645657005059 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 645657005060 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 645657005061 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 645657005062 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 645657005063 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 645657005064 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 645657005065 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 645657005066 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 645657005067 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 645657005068 flagellar motor switch protein; Validated; Region: PRK08119 645657005069 CheC-like family; Region: CheC; pfam04509 645657005070 CheC-like family; Region: CheC; pfam04509 645657005071 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 645657005072 Response regulator receiver domain; Region: Response_reg; pfam00072 645657005073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657005074 active site 645657005075 phosphorylation site [posttranslational modification] 645657005076 intermolecular recognition site; other site 645657005077 dimerization interface [polypeptide binding]; other site 645657005078 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 645657005079 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 645657005080 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 645657005081 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 645657005082 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 645657005083 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 645657005084 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 645657005085 FHIPEP family; Region: FHIPEP; pfam00771 645657005086 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 645657005087 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 645657005088 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 645657005089 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 645657005090 P-loop; other site 645657005091 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 645657005092 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 645657005093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657005094 active site 645657005095 phosphorylation site [posttranslational modification] 645657005096 intermolecular recognition site; other site 645657005097 dimerization interface [polypeptide binding]; other site 645657005098 CheB methylesterase; Region: CheB_methylest; pfam01339 645657005099 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 645657005100 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 645657005101 putative binding surface; other site 645657005102 active site 645657005103 P2 response regulator binding domain; Region: P2; pfam07194 645657005104 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 645657005105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657005106 ATP binding site [chemical binding]; other site 645657005107 Mg2+ binding site [ion binding]; other site 645657005108 G-X-G motif; other site 645657005109 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 645657005110 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 645657005111 putative CheA interaction surface; other site 645657005112 CheC-like family; Region: CheC; pfam04509 645657005113 CheC-like family; Region: CheC; pfam04509 645657005114 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 645657005115 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 645657005116 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657005117 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 645657005118 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657005119 DNA binding residues [nucleotide binding] 645657005120 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 645657005121 rRNA interaction site [nucleotide binding]; other site 645657005122 S8 interaction site; other site 645657005123 putative laminin-1 binding site; other site 645657005124 elongation factor Ts; Provisional; Region: tsf; PRK09377 645657005125 UBA/TS-N domain; Region: UBA; pfam00627 645657005126 Elongation factor TS; Region: EF_TS; pfam00889 645657005127 Elongation factor TS; Region: EF_TS; pfam00889 645657005128 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 645657005129 putative nucleotide binding site [chemical binding]; other site 645657005130 uridine monophosphate binding site [chemical binding]; other site 645657005131 homohexameric interface [polypeptide binding]; other site 645657005132 ribosome recycling factor; Reviewed; Region: frr; PRK00083 645657005133 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 645657005134 hinge region; other site 645657005135 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 645657005136 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 645657005137 catalytic residue [active] 645657005138 putative FPP diphosphate binding site; other site 645657005139 putative FPP binding hydrophobic cleft; other site 645657005140 dimer interface [polypeptide binding]; other site 645657005141 putative IPP diphosphate binding site; other site 645657005142 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 645657005143 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 645657005144 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 645657005145 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 645657005146 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 645657005147 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 645657005148 RIP metalloprotease RseP; Region: TIGR00054 645657005149 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 645657005150 active site 645657005151 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 645657005152 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 645657005153 protein binding site [polypeptide binding]; other site 645657005154 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 645657005155 putative substrate binding region [chemical binding]; other site 645657005156 prolyl-tRNA synthetase; Provisional; Region: PRK09194 645657005157 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 645657005158 dimer interface [polypeptide binding]; other site 645657005159 motif 1; other site 645657005160 active site 645657005161 motif 2; other site 645657005162 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 645657005163 putative deacylase active site [active] 645657005164 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 645657005165 active site 645657005166 motif 3; other site 645657005167 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 645657005168 anticodon binding site; other site 645657005169 DNA polymerase III PolC; Validated; Region: polC; PRK00448 645657005170 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 645657005171 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 645657005172 generic binding surface II; other site 645657005173 generic binding surface I; other site 645657005174 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 645657005175 active site 645657005176 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 645657005177 active site 645657005178 catalytic site [active] 645657005179 substrate binding site [chemical binding]; other site 645657005180 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 645657005181 ribosome maturation protein RimP; Reviewed; Region: PRK00092 645657005182 Sm and related proteins; Region: Sm_like; cl00259 645657005183 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 645657005184 putative oligomer interface [polypeptide binding]; other site 645657005185 putative RNA binding site [nucleotide binding]; other site 645657005186 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 645657005187 NusA N-terminal domain; Region: NusA_N; pfam08529 645657005188 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 645657005189 RNA binding site [nucleotide binding]; other site 645657005190 homodimer interface [polypeptide binding]; other site 645657005191 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 645657005192 G-X-X-G motif; other site 645657005193 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 645657005194 G-X-X-G motif; other site 645657005195 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 645657005196 putative RNA binding cleft [nucleotide binding]; other site 645657005197 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 645657005198 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 645657005199 translation initiation factor IF-2; Region: IF-2; TIGR00487 645657005200 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 645657005201 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 645657005202 G1 box; other site 645657005203 putative GEF interaction site [polypeptide binding]; other site 645657005204 GTP/Mg2+ binding site [chemical binding]; other site 645657005205 Switch I region; other site 645657005206 G2 box; other site 645657005207 G3 box; other site 645657005208 Switch II region; other site 645657005209 G4 box; other site 645657005210 G5 box; other site 645657005211 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 645657005212 Translation-initiation factor 2; Region: IF-2; pfam11987 645657005213 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 645657005214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 645657005215 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 645657005216 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 645657005217 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 645657005218 RNA binding site [nucleotide binding]; other site 645657005219 active site 645657005220 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 645657005221 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 645657005222 active site 645657005223 Riboflavin kinase; Region: Flavokinase; smart00904 645657005224 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 645657005225 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 645657005226 RNase E interface [polypeptide binding]; other site 645657005227 trimer interface [polypeptide binding]; other site 645657005228 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 645657005229 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 645657005230 RNase E interface [polypeptide binding]; other site 645657005231 trimer interface [polypeptide binding]; other site 645657005232 active site 645657005233 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 645657005234 putative nucleic acid binding region [nucleotide binding]; other site 645657005235 G-X-X-G motif; other site 645657005236 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 645657005237 RNA binding site [nucleotide binding]; other site 645657005238 domain interface; other site 645657005239 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 645657005240 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 645657005241 NodB motif; other site 645657005242 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 645657005243 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 645657005244 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 645657005245 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 645657005246 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 645657005247 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 645657005248 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 645657005249 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 645657005250 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 645657005251 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 645657005252 aspartate kinase I; Reviewed; Region: PRK08210 645657005253 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 645657005254 putative catalytic residues [active] 645657005255 putative nucleotide binding site [chemical binding]; other site 645657005256 putative aspartate binding site [chemical binding]; other site 645657005257 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 645657005258 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 645657005259 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 645657005260 dihydrodipicolinate synthase; Region: dapA; TIGR00674 645657005261 dimer interface [polypeptide binding]; other site 645657005262 active site 645657005263 catalytic residue [active] 645657005264 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 645657005265 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645657005266 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 645657005267 Clp protease; Region: CLP_protease; pfam00574 645657005268 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 645657005269 active site 645657005270 YlzJ-like protein; Region: YlzJ; pfam14035 645657005271 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 645657005272 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 645657005273 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 645657005274 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 645657005275 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 645657005276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657005277 DNA-binding site [nucleotide binding]; DNA binding site 645657005278 UTRA domain; Region: UTRA; pfam07702 645657005279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657005280 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657005281 putative substrate translocation pore; other site 645657005282 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 645657005283 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 645657005284 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 645657005285 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 645657005286 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 645657005287 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 645657005288 classical (c) SDRs; Region: SDR_c; cd05233 645657005289 NAD(P) binding site [chemical binding]; other site 645657005290 active site 645657005291 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 645657005292 ACT domain; Region: ACT; pfam01842 645657005293 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 645657005294 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 645657005295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657005296 non-specific DNA binding site [nucleotide binding]; other site 645657005297 salt bridge; other site 645657005298 sequence-specific DNA binding site [nucleotide binding]; other site 645657005299 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 645657005300 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 645657005301 competence damage-inducible protein A; Provisional; Region: PRK00549 645657005302 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 645657005303 putative MPT binding site; other site 645657005304 competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199 645657005305 recombinase A; Provisional; Region: recA; PRK09354 645657005306 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 645657005307 hexamer interface [polypeptide binding]; other site 645657005308 Walker A motif; other site 645657005309 ATP binding site [chemical binding]; other site 645657005310 Walker B motif; other site 645657005311 Beta-lactamase; Region: Beta-lactamase; pfam00144 645657005312 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 645657005313 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 645657005314 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 645657005315 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645657005316 Zn2+ binding site [ion binding]; other site 645657005317 Mg2+ binding site [ion binding]; other site 645657005318 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 645657005319 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 645657005320 putative active site [active] 645657005321 metal binding site [ion binding]; metal-binding site 645657005322 homodimer binding site [polypeptide binding]; other site 645657005323 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 645657005324 Threonine dehydrogenase; Region: TDH; cd05281 645657005325 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 645657005326 structural Zn binding site [ion binding]; other site 645657005327 catalytic Zn binding site [ion binding]; other site 645657005328 tetramer interface [polypeptide binding]; other site 645657005329 NADP binding site [chemical binding]; other site 645657005330 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 645657005331 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 645657005332 substrate-cofactor binding pocket; other site 645657005333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657005334 catalytic residue [active] 645657005335 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 645657005336 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 645657005337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645657005338 FeS/SAM binding site; other site 645657005339 TRAM domain; Region: TRAM; pfam01938 645657005340 Predicted membrane protein [Function unknown]; Region: COG4550 645657005341 Outer spore coat protein E (CotE); Region: CotE; pfam10628 645657005342 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 645657005343 MutS domain I; Region: MutS_I; pfam01624 645657005344 MutS domain II; Region: MutS_II; pfam05188 645657005345 MutS domain III; Region: MutS_III; pfam05192 645657005346 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 645657005347 Walker A/P-loop; other site 645657005348 ATP binding site [chemical binding]; other site 645657005349 Q-loop/lid; other site 645657005350 ABC transporter signature motif; other site 645657005351 Walker B; other site 645657005352 D-loop; other site 645657005353 H-loop/switch region; other site 645657005354 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 645657005355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657005356 ATP binding site [chemical binding]; other site 645657005357 Mg2+ binding site [ion binding]; other site 645657005358 G-X-G motif; other site 645657005359 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 645657005360 ATP binding site [chemical binding]; other site 645657005361 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 645657005362 Regulatory protein YrvL; Region: YrvL; pfam14184 645657005363 transcriptional regulator BetI; Validated; Region: PRK00767 645657005364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657005365 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 645657005366 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645657005367 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 645657005368 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 645657005369 active site 645657005370 catalytic triad [active] 645657005371 WYL domain; Region: WYL; cl14852 645657005372 Phage-related replication protein [General function prediction only]; Region: COG4195 645657005373 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 645657005374 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 645657005375 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 645657005376 YmaF family; Region: YmaF; pfam12788 645657005377 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 645657005378 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 645657005379 bacterial Hfq-like; Region: Hfq; cd01716 645657005380 hexamer interface [polypeptide binding]; other site 645657005381 Sm1 motif; other site 645657005382 RNA binding site [nucleotide binding]; other site 645657005383 Sm2 motif; other site 645657005384 YmzC-like protein; Region: YmzC; pfam14157 645657005385 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 645657005386 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 645657005387 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 645657005388 Class I ribonucleotide reductase; Region: RNR_I; cd01679 645657005389 active site 645657005390 dimer interface [polypeptide binding]; other site 645657005391 catalytic residues [active] 645657005392 effector binding site; other site 645657005393 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 645657005394 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 645657005395 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 645657005396 dimer interface [polypeptide binding]; other site 645657005397 putative radical transfer pathway; other site 645657005398 diiron center [ion binding]; other site 645657005399 tyrosyl radical; other site 645657005400 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 645657005401 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 645657005402 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645657005403 active site 645657005404 metal binding site [ion binding]; metal-binding site 645657005405 Sporulation related domain; Region: SPOR; pfam05036 645657005406 stage V sporulation protein K; Region: spore_V_K; TIGR02881 645657005407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657005408 Walker A motif; other site 645657005409 ATP binding site [chemical binding]; other site 645657005410 Walker B motif; other site 645657005411 arginine finger; other site 645657005412 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 645657005413 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 645657005414 HflX GTPase family; Region: HflX; cd01878 645657005415 G1 box; other site 645657005416 GTP/Mg2+ binding site [chemical binding]; other site 645657005417 Switch I region; other site 645657005418 G2 box; other site 645657005419 G3 box; other site 645657005420 Switch II region; other site 645657005421 G4 box; other site 645657005422 G5 box; other site 645657005423 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 645657005424 Aluminium resistance protein; Region: Alum_res; pfam06838 645657005425 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 645657005426 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 645657005427 DNA binding residues [nucleotide binding] 645657005428 putative dimer interface [polypeptide binding]; other site 645657005429 glutamine synthetase, type I; Region: GlnA; TIGR00653 645657005430 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 645657005431 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 645657005432 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 645657005433 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 645657005434 Int/Topo IB signature motif; other site 645657005435 Domain of unknown function (DUF955); Region: DUF955; cl01076 645657005436 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645657005437 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657005438 non-specific DNA binding site [nucleotide binding]; other site 645657005439 salt bridge; other site 645657005440 sequence-specific DNA binding site [nucleotide binding]; other site 645657005441 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 645657005442 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 645657005443 Helix-turn-helix domain; Region: HTH_17; cl17695 645657005444 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 645657005445 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645657005446 Protein of unknown function (DUF669); Region: DUF669; pfam05037 645657005447 Uncharacterized conserved protein [Function unknown]; Region: COG4983 645657005448 D5 N terminal like; Region: D5_N; pfam08706 645657005449 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 645657005450 ERCC4 domain; Region: ERCC4; pfam02732 645657005451 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 645657005452 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 645657005453 Phage terminase, small subunit; Region: Terminase_4; pfam05119 645657005454 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 645657005455 Phage-related protein [Function unknown]; Region: COG4695; cl01923 645657005456 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 645657005457 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 645657005458 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 645657005459 Phage capsid family; Region: Phage_capsid; pfam05065 645657005460 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 645657005461 oligomerization interface [polypeptide binding]; other site 645657005462 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 645657005463 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 645657005464 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 645657005465 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 645657005466 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 645657005467 N-acetyl-D-glucosamine binding site [chemical binding]; other site 645657005468 catalytic residue [active] 645657005469 Phage tail protein; Region: Sipho_tail; cl17486 645657005470 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 645657005471 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 645657005472 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 645657005473 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 645657005474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657005475 Walker A motif; other site 645657005476 ATP binding site [chemical binding]; other site 645657005477 Walker B motif; other site 645657005478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 645657005479 Integrase core domain; Region: rve; pfam00665 645657005480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 645657005481 HTH domain; Region: HTH_22; pfam13309 645657005482 Transposase, Mutator family; Region: Transposase_mut; pfam00872 645657005483 MULE transposase domain; Region: MULE; pfam10551 645657005484 CAAX protease self-immunity; Region: Abi; cl00558 645657005485 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 645657005486 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 645657005487 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 645657005488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657005489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 645657005490 Transposase; Region: HTH_Tnp_1; pfam01527 645657005491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 645657005492 HTH-like domain; Region: HTH_21; pfam13276 645657005493 Integrase core domain; Region: rve; pfam00665 645657005494 Integrase core domain; Region: rve_3; pfam13683 645657005495 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 645657005496 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 645657005497 inhibitor binding site; inhibition site 645657005498 active site 645657005499 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645657005500 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 645657005501 non-specific DNA interactions [nucleotide binding]; other site 645657005502 DNA binding site [nucleotide binding] 645657005503 sequence specific DNA binding site [nucleotide binding]; other site 645657005504 putative cAMP binding site [chemical binding]; other site 645657005505 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 645657005506 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645657005507 nucleotide binding site [chemical binding]; other site 645657005508 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 645657005509 xylose isomerase; Provisional; Region: PRK05474 645657005510 xylose isomerase; Region: xylose_isom_A; TIGR02630 645657005511 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 645657005512 N- and C-terminal domain interface [polypeptide binding]; other site 645657005513 D-xylulose kinase; Region: XylB; TIGR01312 645657005514 active site 645657005515 MgATP binding site [chemical binding]; other site 645657005516 catalytic site [active] 645657005517 metal binding site [ion binding]; metal-binding site 645657005518 xylulose binding site [chemical binding]; other site 645657005519 homodimer interface [polypeptide binding]; other site 645657005520 Transposase, Mutator family; Region: Transposase_mut; pfam00872 645657005521 MULE transposase domain; Region: MULE; pfam10551 645657005522 Staphylococcal nuclease homologues; Region: SNc; smart00318 645657005523 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 645657005524 Catalytic site; other site 645657005525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657005526 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 645657005527 putative substrate translocation pore; other site 645657005528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657005529 alanine racemase; Region: alr; TIGR00492 645657005530 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 645657005531 active site 645657005532 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645657005533 dimer interface [polypeptide binding]; other site 645657005534 substrate binding site [chemical binding]; other site 645657005535 catalytic residues [active] 645657005536 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 645657005537 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 645657005538 trimer interface [polypeptide binding]; other site 645657005539 active site 645657005540 thymidylate synthase; Reviewed; Region: thyA; PRK01827 645657005541 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 645657005542 dimerization interface [polypeptide binding]; other site 645657005543 active site 645657005544 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 645657005545 putative binding site; other site 645657005546 putative dimer interface [polypeptide binding]; other site 645657005547 YoqO-like protein; Region: YoqO; pfam14037 645657005548 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 645657005549 Transposase domain (DUF772); Region: DUF772; pfam05598 645657005550 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 645657005551 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 645657005552 putative hydrophobic ligand binding site [chemical binding]; other site 645657005553 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 645657005554 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 645657005555 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 645657005556 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 645657005557 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 645657005558 YndJ-like protein; Region: YndJ; pfam14158 645657005559 Phage-related replication protein [General function prediction only]; Region: COG4195 645657005560 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 645657005561 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 645657005562 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 645657005563 putative active site [active] 645657005564 putative Mg binding site [ion binding]; other site 645657005565 LexA repressor; Validated; Region: PRK00215 645657005566 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657005567 putative DNA binding site [nucleotide binding]; other site 645657005568 putative Zn2+ binding site [ion binding]; other site 645657005569 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 645657005570 Catalytic site [active] 645657005571 cell division suppressor protein YneA; Provisional; Region: PRK14125 645657005572 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657005573 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 645657005574 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 645657005575 catalytic residues [active] 645657005576 catalytic nucleophile [active] 645657005577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 645657005578 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 645657005579 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 645657005580 TPP-binding site [chemical binding]; other site 645657005581 dimer interface [polypeptide binding]; other site 645657005582 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 645657005583 PYR/PP interface [polypeptide binding]; other site 645657005584 dimer interface [polypeptide binding]; other site 645657005585 TPP binding site [chemical binding]; other site 645657005586 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 645657005587 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 645657005588 hypothetical protein; Provisional; Region: PRK01844 645657005589 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 645657005590 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 645657005591 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 645657005592 Response regulator receiver domain; Region: Response_reg; pfam00072 645657005593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657005594 active site 645657005595 phosphorylation site [posttranslational modification] 645657005596 intermolecular recognition site; other site 645657005597 dimerization interface [polypeptide binding]; other site 645657005598 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 645657005599 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 645657005600 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 645657005601 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 645657005602 putative dimer interface [polypeptide binding]; other site 645657005603 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 645657005604 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 645657005605 aconitate hydratase; Validated; Region: PRK09277 645657005606 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 645657005607 substrate binding site [chemical binding]; other site 645657005608 ligand binding site [chemical binding]; other site 645657005609 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 645657005610 substrate binding site [chemical binding]; other site 645657005611 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 645657005612 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 645657005613 catalytic residues [active] 645657005614 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 645657005615 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 645657005616 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 645657005617 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 645657005618 active site 645657005619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 645657005620 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 645657005621 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 645657005622 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 645657005623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657005624 ATP binding site [chemical binding]; other site 645657005625 Mg2+ binding site [ion binding]; other site 645657005626 G-X-G motif; other site 645657005627 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 645657005628 anchoring element; other site 645657005629 dimer interface [polypeptide binding]; other site 645657005630 ATP binding site [chemical binding]; other site 645657005631 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 645657005632 active site 645657005633 putative metal-binding site [ion binding]; other site 645657005634 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 645657005635 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 645657005636 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 645657005637 CAP-like domain; other site 645657005638 active site 645657005639 primary dimer interface [polypeptide binding]; other site 645657005640 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645657005641 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645657005642 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645657005643 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645657005644 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 645657005645 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 645657005646 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 645657005647 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 645657005648 Cellulose binding domain; Region: CBM_3; pfam00942 645657005649 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 645657005650 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 645657005651 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 645657005652 substrate binding site [chemical binding]; other site 645657005653 active site 645657005654 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 645657005655 metal binding site [ion binding]; metal-binding site 645657005656 ligand binding site [chemical binding]; other site 645657005657 Predicted membrane protein [Function unknown]; Region: COG2246 645657005658 GtrA-like protein; Region: GtrA; pfam04138 645657005659 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 645657005660 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 645657005661 active site 645657005662 tetramer interface; other site 645657005663 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 645657005664 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 645657005665 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 645657005666 DHH family; Region: DHH; pfam01368 645657005667 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 645657005668 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 645657005669 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 645657005670 enoyl-CoA hydratase; Provisional; Region: PRK07657 645657005671 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 645657005672 substrate binding site [chemical binding]; other site 645657005673 oxyanion hole (OAH) forming residues; other site 645657005674 trimer interface [polypeptide binding]; other site 645657005675 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 645657005676 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 645657005677 active site 645657005678 catalytic residues [active] 645657005679 metal binding site [ion binding]; metal-binding site 645657005680 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 645657005681 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 645657005682 carboxyltransferase (CT) interaction site; other site 645657005683 biotinylation site [posttranslational modification]; other site 645657005684 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 645657005685 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645657005686 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 645657005687 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 645657005688 AMP-binding domain protein; Validated; Region: PRK08315 645657005689 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645657005690 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 645657005691 acyl-activating enzyme (AAE) consensus motif; other site 645657005692 putative AMP binding site [chemical binding]; other site 645657005693 putative active site [active] 645657005694 putative CoA binding site [chemical binding]; other site 645657005695 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 645657005696 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 645657005697 active site 645657005698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 645657005699 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 645657005700 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 645657005701 from glimmer orf02810 and orf02811; pps genes seem to be broken; plipastatin synthetase 645657005702 peptide synthase; Provisional; Region: PRK12467 645657005703 from glimmer orf02814 and orf02815; pps genes seem to be broken; plipastatin synthetase 645657005704 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 645657005705 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 645657005706 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 645657005707 active site 645657005708 catalytic residues [active] 645657005709 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645657005710 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 645657005711 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 645657005712 Homeodomain-like domain; Region: HTH_23; pfam13384 645657005713 putative transposase OrfB; Reviewed; Region: PHA02517 645657005714 HTH-like domain; Region: HTH_21; pfam13276 645657005715 Integrase core domain; Region: rve; pfam00665 645657005716 Integrase core domain; Region: rve_3; pfam13683 645657005717 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 645657005718 Int/Topo IB signature motif; other site 645657005719 Helix-turn-helix domain; Region: HTH_17; cl17695 645657005720 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 645657005721 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 645657005722 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657005723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657005724 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 645657005725 putative dimerization interface [polypeptide binding]; other site 645657005726 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 645657005727 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 645657005728 NAD(P) binding site [chemical binding]; other site 645657005729 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 645657005730 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645657005731 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 645657005732 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 645657005733 active site 645657005734 dimer interface [polypeptide binding]; other site 645657005735 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 645657005736 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 645657005737 active site 645657005738 FMN binding site [chemical binding]; other site 645657005739 substrate binding site [chemical binding]; other site 645657005740 3Fe-4S cluster binding site [ion binding]; other site 645657005741 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 645657005742 domain interface; other site 645657005743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657005744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657005745 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 645657005746 putative dimerization interface [polypeptide binding]; other site 645657005747 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 645657005748 putative allosteric binding site; other site 645657005749 nucleotide binding site [chemical binding]; other site 645657005750 PUA domain; Region: PUA; pfam01472 645657005751 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 645657005752 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 645657005753 Replication terminator protein; Region: RTP; pfam02334 645657005754 Replication terminator protein; Region: RTP; pfam02334 645657005755 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 645657005756 classical (c) SDRs; Region: SDR_c; cd05233 645657005757 NAD(P) binding site [chemical binding]; other site 645657005758 active site 645657005759 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 645657005760 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 645657005761 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 645657005762 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645657005763 ABC-2 type transporter; Region: ABC2_membrane; cl17235 645657005764 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645657005765 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645657005766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657005767 Walker A/P-loop; other site 645657005768 ATP binding site [chemical binding]; other site 645657005769 Q-loop/lid; other site 645657005770 ABC transporter signature motif; other site 645657005771 Walker B; other site 645657005772 D-loop; other site 645657005773 H-loop/switch region; other site 645657005774 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657005775 MarR family; Region: MarR_2; pfam12802 645657005776 MarR family; Region: MarR_2; cl17246 645657005777 polyol permease family; Region: 2A0118; TIGR00897 645657005778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657005779 putative substrate translocation pore; other site 645657005780 Transposase, Mutator family; Region: Transposase_mut; pfam00872 645657005781 MULE transposase domain; Region: MULE; pfam10551 645657005782 DNA polymerase IV; Reviewed; Region: PRK03103 645657005783 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 645657005784 Y-family of DNA polymerases; Region: PolY; cl12025 645657005785 active site 645657005786 YolD-like protein; Region: YolD; pfam08863 645657005787 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 645657005788 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 645657005789 Coenzyme A binding pocket [chemical binding]; other site 645657005790 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 645657005791 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 645657005792 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 645657005793 Uncharacterized conserved protein [Function unknown]; Region: COG5444 645657005794 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 645657005795 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 645657005796 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 645657005797 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 645657005798 dimer interface [polypeptide binding]; other site 645657005799 putative tRNA-binding site [nucleotide binding]; other site 645657005800 Cupin domain; Region: Cupin_2; pfam07883 645657005801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657005802 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645657005803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657005804 Coenzyme A binding pocket [chemical binding]; other site 645657005805 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657005806 WHG domain; Region: WHG; pfam13305 645657005807 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645657005808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 645657005809 Predicted transcriptional regulator [Transcription]; Region: COG2378 645657005810 HTH domain; Region: HTH_11; pfam08279 645657005811 WYL domain; Region: WYL; pfam13280 645657005812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657005813 dimerization interface [polypeptide binding]; other site 645657005814 putative DNA binding site [nucleotide binding]; other site 645657005815 putative Zn2+ binding site [ion binding]; other site 645657005816 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 645657005817 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 645657005818 N-acetyl-D-glucosamine binding site [chemical binding]; other site 645657005819 catalytic residue [active] 645657005820 Predicted membrane protein [Function unknown]; Region: COG2322 645657005821 Protein required for attachment to host cells; Region: Host_attach; cl02398 645657005822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645657005823 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 645657005824 putative dimer interface [polypeptide binding]; other site 645657005825 catalytic triad [active] 645657005826 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 645657005827 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 645657005828 putative di-iron ligands [ion binding]; other site 645657005829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 645657005830 Histidine kinase; Region: HisKA_3; pfam07730 645657005831 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 645657005832 ATP binding site [chemical binding]; other site 645657005833 Mg2+ binding site [ion binding]; other site 645657005834 G-X-G motif; other site 645657005835 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645657005836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657005837 active site 645657005838 phosphorylation site [posttranslational modification] 645657005839 intermolecular recognition site; other site 645657005840 dimerization interface [polypeptide binding]; other site 645657005841 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645657005842 DNA binding residues [nucleotide binding] 645657005843 dimerization interface [polypeptide binding]; other site 645657005844 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657005845 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657005846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 645657005847 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 645657005848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645657005849 ATP binding site [chemical binding]; other site 645657005850 putative Mg++ binding site [ion binding]; other site 645657005851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657005852 nucleotide binding region [chemical binding]; other site 645657005853 ATP-binding site [chemical binding]; other site 645657005854 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 645657005855 Helicase and RNase D C-terminal; Region: HRDC; smart00341 645657005856 azoreductase; Provisional; Region: PRK13556 645657005857 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 645657005858 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 645657005859 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 645657005860 putative dimer interface [polypeptide binding]; other site 645657005861 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 645657005862 pentamer interface [polypeptide binding]; other site 645657005863 dodecaamer interface [polypeptide binding]; other site 645657005864 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 645657005865 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 645657005866 NAD(P) binding site [chemical binding]; other site 645657005867 catalytic residues [active] 645657005868 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 645657005869 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 645657005870 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 645657005871 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 645657005872 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 645657005873 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 645657005874 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 645657005875 Na2 binding site [ion binding]; other site 645657005876 putative substrate binding site 1 [chemical binding]; other site 645657005877 Na binding site 1 [ion binding]; other site 645657005878 putative substrate binding site 2 [chemical binding]; other site 645657005879 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 645657005880 Sodium Bile acid symporter family; Region: SBF; pfam01758 645657005881 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 645657005882 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 645657005883 E3 interaction surface; other site 645657005884 lipoyl attachment site [posttranslational modification]; other site 645657005885 e3 binding domain; Region: E3_binding; pfam02817 645657005886 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 645657005887 2-oxoglutarate dehydrogenase, E1 component; Region: 2oxo_dh_E1; TIGR00239 645657005888 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 645657005889 TPP-binding site [chemical binding]; other site 645657005890 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 645657005891 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 645657005892 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 645657005893 metal ion-dependent adhesion site (MIDAS); other site 645657005894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657005895 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645657005896 Walker A motif; other site 645657005897 ATP binding site [chemical binding]; other site 645657005898 Walker B motif; other site 645657005899 arginine finger; other site 645657005900 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 645657005901 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 645657005902 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 645657005903 E-class dimer interface [polypeptide binding]; other site 645657005904 P-class dimer interface [polypeptide binding]; other site 645657005905 active site 645657005906 Cu2+ binding site [ion binding]; other site 645657005907 Zn2+ binding site [ion binding]; other site 645657005908 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657005909 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657005910 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657005911 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657005912 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645657005913 NlpC/P60 family; Region: NLPC_P60; pfam00877 645657005914 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 645657005915 glycosyltransferase, MGT family; Region: MGT; TIGR01426 645657005916 active site 645657005917 TDP-binding site; other site 645657005918 acceptor substrate-binding pocket; other site 645657005919 Uncharacterized conserved protein [Function unknown]; Region: COG1624 645657005920 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 645657005921 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 645657005922 multidrug efflux protein; Reviewed; Region: PRK01766 645657005923 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 645657005924 cation binding site [ion binding]; other site 645657005925 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 645657005926 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 645657005927 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 645657005928 rarD protein; Region: rarD; TIGR00688 645657005929 EamA-like transporter family; Region: EamA; pfam00892 645657005930 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 645657005931 fructuronate transporter; Provisional; Region: PRK10034; cl15264 645657005932 fructuronate transporter; Provisional; Region: PRK10034; cl15264 645657005933 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 645657005934 Predicted transcriptional regulators [Transcription]; Region: COG1733 645657005935 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657005936 dimerization interface [polypeptide binding]; other site 645657005937 putative DNA binding site [nucleotide binding]; other site 645657005938 putative Zn2+ binding site [ion binding]; other site 645657005939 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 645657005940 dimer interface [polypeptide binding]; other site 645657005941 FMN binding site [chemical binding]; other site 645657005942 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 645657005943 Homeodomain-like domain; Region: HTH_23; pfam13384 645657005944 putative transposase OrfB; Reviewed; Region: PHA02517 645657005945 HTH-like domain; Region: HTH_21; pfam13276 645657005946 Integrase core domain; Region: rve; pfam00665 645657005947 Integrase core domain; Region: rve_3; pfam13683 645657005948 Predicted esterase [General function prediction only]; Region: COG0400 645657005949 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 645657005950 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657005951 Zn binding site [ion binding]; other site 645657005952 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 645657005953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657005954 Zn binding site [ion binding]; other site 645657005955 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 645657005956 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 645657005957 Na binding site [ion binding]; other site 645657005958 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 645657005959 C-terminal peptidase (prc); Region: prc; TIGR00225 645657005960 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 645657005961 protein binding site [polypeptide binding]; other site 645657005962 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 645657005963 Catalytic dyad [active] 645657005964 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 645657005965 Methyltransferase domain; Region: Methyltransf_31; pfam13847 645657005966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657005967 S-adenosylmethionine binding site [chemical binding]; other site 645657005968 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 645657005969 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 645657005970 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 645657005971 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 645657005972 YodL-like; Region: YodL; pfam14191 645657005973 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 645657005974 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 645657005975 active site 645657005976 YozD-like protein; Region: YozD; pfam14162 645657005977 hypothetical protein; Provisional; Region: PRK13672 645657005978 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 645657005979 toxin interface [polypeptide binding]; other site 645657005980 Zn binding site [ion binding]; other site 645657005981 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 645657005982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645657005983 FeS/SAM binding site; other site 645657005984 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 645657005985 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 645657005986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657005987 Coenzyme A binding pocket [chemical binding]; other site 645657005988 acetylornithine deacetylase; Validated; Region: PRK06915 645657005989 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 645657005990 metal binding site [ion binding]; metal-binding site 645657005991 dimer interface [polypeptide binding]; other site 645657005992 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 645657005993 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 645657005994 hypothetical protein; Provisional; Region: PRK06917 645657005995 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645657005996 inhibitor-cofactor binding pocket; inhibition site 645657005997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657005998 catalytic residue [active] 645657005999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657006000 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 645657006001 Coenzyme A binding pocket [chemical binding]; other site 645657006002 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 645657006003 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 645657006004 active site 645657006005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 645657006006 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 645657006007 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 645657006008 Phytase; Region: Phytase; cl17685 645657006009 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 645657006010 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 645657006011 NAD(P) binding site [chemical binding]; other site 645657006012 homodimer interface [polypeptide binding]; other site 645657006013 substrate binding site [chemical binding]; other site 645657006014 active site 645657006015 methionine sulfoxide reductase B; Provisional; Region: PRK00222 645657006016 SelR domain; Region: SelR; pfam01641 645657006017 methionine sulfoxide reductase A; Provisional; Region: PRK14054 645657006018 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657006019 MarR family; Region: MarR; pfam01047 645657006020 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645657006021 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 645657006022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 645657006023 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 645657006024 active site 645657006025 catalytic triad [active] 645657006026 oxyanion hole [active] 645657006027 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 645657006028 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 645657006029 Cu(I) binding site [ion binding]; other site 645657006030 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 645657006031 threonine dehydratase; Validated; Region: PRK08639 645657006032 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 645657006033 tetramer interface [polypeptide binding]; other site 645657006034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657006035 catalytic residue [active] 645657006036 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 645657006037 putative Ile/Val binding site [chemical binding]; other site 645657006038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657006039 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645657006040 Walker A motif; other site 645657006041 ATP binding site [chemical binding]; other site 645657006042 Walker B motif; other site 645657006043 arginine finger; other site 645657006044 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 645657006045 Haemolysin-III related; Region: HlyIII; cl03831 645657006046 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 645657006047 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 645657006048 putative acyl-acceptor binding pocket; other site 645657006049 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 645657006050 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 645657006051 folate binding site [chemical binding]; other site 645657006052 NADP+ binding site [chemical binding]; other site 645657006053 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 645657006054 tetramer interfaces [polypeptide binding]; other site 645657006055 binuclear metal-binding site [ion binding]; other site 645657006056 YpjP-like protein; Region: YpjP; pfam14005 645657006057 ribosomal biogenesis protein; Validated; Region: PRK00933 645657006058 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 645657006059 Disulphide isomerase; Region: Disulph_isomer; pfam06491 645657006060 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 645657006061 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 645657006062 Virulence factor; Region: Virulence_fact; pfam13769 645657006063 HEAT repeats; Region: HEAT_2; pfam13646 645657006064 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 645657006065 HEAT repeats; Region: HEAT_2; pfam13646 645657006066 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 645657006067 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 645657006068 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645657006069 Zn2+ binding site [ion binding]; other site 645657006070 Mg2+ binding site [ion binding]; other site 645657006071 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 645657006072 catalytic residues [active] 645657006073 dimer interface [polypeptide binding]; other site 645657006074 homoserine O-succinyltransferase; Provisional; Region: PRK05368 645657006075 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 645657006076 proposed active site lysine [active] 645657006077 conserved cys residue [active] 645657006078 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 645657006079 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 645657006080 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 645657006081 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 645657006082 DNA-binding site [nucleotide binding]; DNA binding site 645657006083 RNA-binding motif; other site 645657006084 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 645657006085 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 645657006086 hypothetical protein; Validated; Region: PRK07708 645657006087 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 645657006088 RNA/DNA hybrid binding site [nucleotide binding]; other site 645657006089 active site 645657006090 conserved hypothetical integral membrane protein; Region: TIGR00697 645657006091 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 645657006092 RNA/DNA hybrid binding site [nucleotide binding]; other site 645657006093 active site 645657006094 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 645657006095 5'-3' exonuclease; Region: 53EXOc; smart00475 645657006096 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 645657006097 active site 645657006098 metal binding site 1 [ion binding]; metal-binding site 645657006099 putative 5' ssDNA interaction site; other site 645657006100 metal binding site 3; metal-binding site 645657006101 metal binding site 2 [ion binding]; metal-binding site 645657006102 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 645657006103 putative DNA binding site [nucleotide binding]; other site 645657006104 putative metal binding site [ion binding]; other site 645657006105 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 645657006106 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 645657006107 Dynamin family; Region: Dynamin_N; pfam00350 645657006108 G1 box; other site 645657006109 GTP/Mg2+ binding site [chemical binding]; other site 645657006110 G2 box; other site 645657006111 Switch I region; other site 645657006112 G3 box; other site 645657006113 Switch II region; other site 645657006114 G4 box; other site 645657006115 G5 box; other site 645657006116 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 645657006117 G1 box; other site 645657006118 GTP/Mg2+ binding site [chemical binding]; other site 645657006119 Dynamin family; Region: Dynamin_N; pfam00350 645657006120 G2 box; other site 645657006121 Switch I region; other site 645657006122 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 645657006123 G3 box; other site 645657006124 Switch II region; other site 645657006125 GTP/Mg2+ binding site [chemical binding]; other site 645657006126 G4 box; other site 645657006127 G5 box; other site 645657006128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 645657006129 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 645657006130 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 645657006131 malonyl-CoA binding site [chemical binding]; other site 645657006132 dimer interface [polypeptide binding]; other site 645657006133 active site 645657006134 product binding site; other site 645657006135 xanthine permease; Region: pbuX; TIGR03173 645657006136 Sulfate transporter family; Region: Sulfate_transp; pfam00916 645657006137 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645657006138 active site 645657006139 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 645657006140 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 645657006141 active site 645657006142 Zn binding site [ion binding]; other site 645657006143 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 645657006144 Entner-Doudoroff aldolase; Region: eda; TIGR01182 645657006145 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 645657006146 active site 645657006147 intersubunit interface [polypeptide binding]; other site 645657006148 catalytic residue [active] 645657006149 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 645657006150 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 645657006151 substrate binding site [chemical binding]; other site 645657006152 ATP binding site [chemical binding]; other site 645657006153 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645657006154 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645657006155 DNA binding site [nucleotide binding] 645657006156 domain linker motif; other site 645657006157 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 645657006158 putative dimerization interface [polypeptide binding]; other site 645657006159 putative ligand binding site [chemical binding]; other site 645657006160 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 645657006161 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 645657006162 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 645657006163 NADP binding site [chemical binding]; other site 645657006164 homodimer interface [polypeptide binding]; other site 645657006165 active site 645657006166 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 645657006167 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 645657006168 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 645657006169 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 645657006170 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 645657006171 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 645657006172 cell division protein GpsB; Provisional; Region: PRK14127 645657006173 DivIVA domain; Region: DivI1A_domain; TIGR03544 645657006174 hypothetical protein; Provisional; Region: PRK13660 645657006175 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 645657006176 RNase_H superfamily; Region: RNase_H_2; pfam13482 645657006177 active site 645657006178 substrate binding site [chemical binding]; other site 645657006179 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 645657006180 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645657006181 ATP binding site [chemical binding]; other site 645657006182 putative Mg++ binding site [ion binding]; other site 645657006183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657006184 nucleotide binding region [chemical binding]; other site 645657006185 ATP-binding site [chemical binding]; other site 645657006186 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 645657006187 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645657006188 HPr interaction site; other site 645657006189 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645657006190 active site 645657006191 phosphorylation site [posttranslational modification] 645657006192 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 645657006193 YppG-like protein; Region: YppG; pfam14179 645657006194 YppF-like protein; Region: YppF; pfam14178 645657006195 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 645657006196 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 645657006197 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 645657006198 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 645657006199 Transglycosylase; Region: Transgly; pfam00912 645657006200 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645657006201 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 645657006202 Interdomain contacts; other site 645657006203 Cytokine receptor motif; other site 645657006204 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 645657006205 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 645657006206 minor groove reading motif; other site 645657006207 helix-hairpin-helix signature motif; other site 645657006208 substrate binding pocket [chemical binding]; other site 645657006209 active site 645657006210 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 645657006211 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 645657006212 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 645657006213 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 645657006214 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 645657006215 putative dimer interface [polypeptide binding]; other site 645657006216 putative anticodon binding site; other site 645657006217 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 645657006218 homodimer interface [polypeptide binding]; other site 645657006219 motif 1; other site 645657006220 motif 2; other site 645657006221 active site 645657006222 motif 3; other site 645657006223 aspartate aminotransferase; Provisional; Region: PRK05764 645657006224 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657006225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657006226 homodimer interface [polypeptide binding]; other site 645657006227 catalytic residue [active] 645657006228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 645657006229 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 645657006230 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 645657006231 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 645657006232 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 645657006233 active site 645657006234 catalytic site [active] 645657006235 substrate binding site [chemical binding]; other site 645657006236 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 645657006237 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 645657006238 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 645657006239 tetramerization interface [polypeptide binding]; other site 645657006240 active site 645657006241 pantoate--beta-alanine ligase; Region: panC; TIGR00018 645657006242 Pantoate-beta-alanine ligase; Region: PanC; cd00560 645657006243 active site 645657006244 ATP-binding site [chemical binding]; other site 645657006245 pantoate-binding site; other site 645657006246 HXXH motif; other site 645657006247 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 645657006248 oligomerization interface [polypeptide binding]; other site 645657006249 active site 645657006250 metal binding site [ion binding]; metal-binding site 645657006251 Biotin operon repressor [Transcription]; Region: BirA; COG1654 645657006252 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 645657006253 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 645657006254 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 645657006255 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 645657006256 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 645657006257 active site 645657006258 NTP binding site [chemical binding]; other site 645657006259 metal binding triad [ion binding]; metal-binding site 645657006260 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 645657006261 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 645657006262 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 645657006263 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 645657006264 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 645657006265 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 645657006266 active site 645657006267 dimer interfaces [polypeptide binding]; other site 645657006268 catalytic residues [active] 645657006269 dihydrodipicolinate reductase; Region: dapB; TIGR00036 645657006270 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 645657006271 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 645657006272 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 645657006273 homodimer interface [polypeptide binding]; other site 645657006274 metal binding site [ion binding]; metal-binding site 645657006275 Uncharacterized conserved protein [Function unknown]; Region: COG1284 645657006276 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645657006277 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645657006278 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 645657006279 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 645657006280 Predicted membrane protein [Function unknown]; Region: COG4347 645657006281 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 645657006282 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 645657006283 intrachain domain interface; other site 645657006284 Qi binding site; other site 645657006285 Qo binding site; other site 645657006286 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 645657006287 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 645657006288 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 645657006289 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 645657006290 interchain domain interface [polypeptide binding]; other site 645657006291 intrachain domain interface; other site 645657006292 heme bH binding site [chemical binding]; other site 645657006293 Qi binding site; other site 645657006294 heme bL binding site [chemical binding]; other site 645657006295 Qo binding site; other site 645657006296 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 645657006297 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 645657006298 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 645657006299 iron-sulfur cluster [ion binding]; other site 645657006300 [2Fe-2S] cluster binding site [ion binding]; other site 645657006301 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 645657006302 hypothetical protein; Provisional; Region: PRK03636 645657006303 UPF0302 domain; Region: UPF0302; pfam08864 645657006304 IDEAL domain; Region: IDEAL; pfam08858 645657006305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657006306 TPR motif; other site 645657006307 binding surface 645657006308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657006309 binding surface 645657006310 TPR motif; other site 645657006311 Tetratricopeptide repeat; Region: TPR_16; pfam13432 645657006312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657006313 TPR motif; other site 645657006314 binding surface 645657006315 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 645657006316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657006317 binding surface 645657006318 TPR motif; other site 645657006319 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 645657006320 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 645657006321 hinge; other site 645657006322 active site 645657006323 prephenate dehydrogenase; Validated; Region: PRK06545 645657006324 prephenate dehydrogenase; Validated; Region: PRK08507 645657006325 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 645657006326 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 645657006327 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657006328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657006329 homodimer interface [polypeptide binding]; other site 645657006330 catalytic residue [active] 645657006331 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 645657006332 substrate binding site [chemical binding]; other site 645657006333 active site 645657006334 catalytic residues [active] 645657006335 heterodimer interface [polypeptide binding]; other site 645657006336 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 645657006337 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 645657006338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657006339 catalytic residue [active] 645657006340 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 645657006341 active site 645657006342 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 645657006343 active site 645657006344 ribulose/triose binding site [chemical binding]; other site 645657006345 phosphate binding site [ion binding]; other site 645657006346 substrate (anthranilate) binding pocket [chemical binding]; other site 645657006347 product (indole) binding pocket [chemical binding]; other site 645657006348 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 645657006349 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 645657006350 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 645657006351 anthranilate synthase component I; Provisional; Region: PRK13569 645657006352 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 645657006353 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 645657006354 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 645657006355 homotrimer interaction site [polypeptide binding]; other site 645657006356 active site 645657006357 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 645657006358 active site 645657006359 dimer interface [polypeptide binding]; other site 645657006360 metal binding site [ion binding]; metal-binding site 645657006361 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 645657006362 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 645657006363 Tetramer interface [polypeptide binding]; other site 645657006364 active site 645657006365 FMN-binding site [chemical binding]; other site 645657006366 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 645657006367 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 645657006368 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 645657006369 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 645657006370 active site 645657006371 multimer interface [polypeptide binding]; other site 645657006372 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 645657006373 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 645657006374 substrate binding pocket [chemical binding]; other site 645657006375 chain length determination region; other site 645657006376 substrate-Mg2+ binding site; other site 645657006377 catalytic residues [active] 645657006378 aspartate-rich region 1; other site 645657006379 active site lid residues [active] 645657006380 aspartate-rich region 2; other site 645657006381 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 645657006382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657006383 S-adenosylmethionine binding site [chemical binding]; other site 645657006384 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 645657006385 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 645657006386 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 645657006387 homodecamer interface [polypeptide binding]; other site 645657006388 GTP cyclohydrolase I; Provisional; Region: PLN03044 645657006389 active site 645657006390 putative catalytic site residues [active] 645657006391 zinc binding site [ion binding]; other site 645657006392 GTP-CH-I/GFRP interaction surface; other site 645657006393 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 645657006394 IHF dimer interface [polypeptide binding]; other site 645657006395 IHF - DNA interface [nucleotide binding]; other site 645657006396 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 645657006397 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 645657006398 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 645657006399 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 645657006400 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 645657006401 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 645657006402 GTP-binding protein Der; Reviewed; Region: PRK00093 645657006403 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 645657006404 G1 box; other site 645657006405 GTP/Mg2+ binding site [chemical binding]; other site 645657006406 Switch I region; other site 645657006407 G2 box; other site 645657006408 Switch II region; other site 645657006409 G3 box; other site 645657006410 G4 box; other site 645657006411 G5 box; other site 645657006412 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 645657006413 G1 box; other site 645657006414 GTP/Mg2+ binding site [chemical binding]; other site 645657006415 Switch I region; other site 645657006416 G2 box; other site 645657006417 G3 box; other site 645657006418 Switch II region; other site 645657006419 G4 box; other site 645657006420 G5 box; other site 645657006421 YIEGIA protein; Region: YIEGIA; pfam14045 645657006422 YpzI-like protein; Region: YpzI; pfam14140 645657006423 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 645657006424 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 645657006425 homotetramer interface [polypeptide binding]; other site 645657006426 FMN binding site [chemical binding]; other site 645657006427 homodimer contacts [polypeptide binding]; other site 645657006428 putative active site [active] 645657006429 putative substrate binding site [chemical binding]; other site 645657006430 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 645657006431 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 645657006432 RNA binding site [nucleotide binding]; other site 645657006433 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 645657006434 RNA binding site [nucleotide binding]; other site 645657006435 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 645657006436 RNA binding site [nucleotide binding]; other site 645657006437 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 645657006438 RNA binding site [nucleotide binding]; other site 645657006439 cytidylate kinase; Provisional; Region: cmk; PRK00023 645657006440 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 645657006441 CMP-binding site; other site 645657006442 The sites determining sugar specificity; other site 645657006443 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 645657006444 Flagellar protein YcgR; Region: YcgR_2; pfam12945 645657006445 PilZ domain; Region: PilZ; pfam07238 645657006446 germination protein YpeB; Region: spore_YpeB; TIGR02889 645657006447 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 645657006448 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 645657006449 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 645657006450 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 645657006451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 645657006452 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645657006453 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 645657006454 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 645657006455 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 645657006456 NAD(P) binding site [chemical binding]; other site 645657006457 adaptor protein; Provisional; Region: PRK02899 645657006458 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 645657006459 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 645657006460 putative active site [active] 645657006461 putative metal binding site [ion binding]; other site 645657006462 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 645657006463 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657006464 CAAX protease self-immunity; Region: Abi; pfam02517 645657006465 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 645657006466 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645657006467 ATP binding site [chemical binding]; other site 645657006468 putative Mg++ binding site [ion binding]; other site 645657006469 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657006470 nucleotide binding region [chemical binding]; other site 645657006471 ATP-binding site [chemical binding]; other site 645657006472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 645657006473 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 645657006474 Predicted membrane protein [Function unknown]; Region: COG3601 645657006475 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 645657006476 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 645657006477 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 645657006478 ligand binding site [chemical binding]; other site 645657006479 NAD binding site [chemical binding]; other site 645657006480 dimerization interface [polypeptide binding]; other site 645657006481 catalytic site [active] 645657006482 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 645657006483 putative L-serine binding site [chemical binding]; other site 645657006484 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 645657006485 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 645657006486 active site 645657006487 catalytic residue [active] 645657006488 dimer interface [polypeptide binding]; other site 645657006489 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 645657006490 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657006491 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657006492 DNA binding residues [nucleotide binding] 645657006493 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 645657006494 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645657006495 dimerization interface [polypeptide binding]; other site 645657006496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657006497 putative active site [active] 645657006498 heme pocket [chemical binding]; other site 645657006499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657006500 dimer interface [polypeptide binding]; other site 645657006501 phosphorylation site [posttranslational modification] 645657006502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657006503 ATP binding site [chemical binding]; other site 645657006504 Mg2+ binding site [ion binding]; other site 645657006505 G-X-G motif; other site 645657006506 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645657006507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657006508 active site 645657006509 phosphorylation site [posttranslational modification] 645657006510 intermolecular recognition site; other site 645657006511 dimerization interface [polypeptide binding]; other site 645657006512 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645657006513 DNA binding site [nucleotide binding] 645657006514 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 645657006515 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 645657006516 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 645657006517 ResB-like family; Region: ResB; pfam05140 645657006518 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 645657006519 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 645657006520 catalytic residues [active] 645657006521 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 645657006522 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645657006523 RNA binding surface [nucleotide binding]; other site 645657006524 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 645657006525 active site 645657006526 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 645657006527 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 645657006528 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 645657006529 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 645657006530 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 645657006531 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 645657006532 segregation and condensation protein B; Region: TIGR00281 645657006533 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 645657006534 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 645657006535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657006536 Coenzyme A binding pocket [chemical binding]; other site 645657006537 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 645657006538 homopentamer interface [polypeptide binding]; other site 645657006539 active site 645657006540 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 645657006541 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 645657006542 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 645657006543 dimerization interface [polypeptide binding]; other site 645657006544 active site 645657006545 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 645657006546 Lumazine binding domain; Region: Lum_binding; pfam00677 645657006547 Lumazine binding domain; Region: Lum_binding; pfam00677 645657006548 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 645657006549 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 645657006550 catalytic motif [active] 645657006551 Zn binding site [ion binding]; other site 645657006552 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 645657006553 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 645657006554 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 645657006555 Catalytic site [active] 645657006556 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 645657006557 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 645657006558 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 645657006559 active site 645657006560 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 645657006561 Predicted secreted protein [Function unknown]; Region: COG4086 645657006562 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 645657006563 diaminopimelate decarboxylase; Region: lysA; TIGR01048 645657006564 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 645657006565 active site 645657006566 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645657006567 substrate binding site [chemical binding]; other site 645657006568 catalytic residues [active] 645657006569 dimer interface [polypeptide binding]; other site 645657006570 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 645657006571 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 645657006572 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 645657006573 stage V sporulation protein AD; Validated; Region: PRK08304 645657006574 stage V sporulation protein AD; Provisional; Region: PRK12404 645657006575 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 645657006576 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 645657006577 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 645657006578 sporulation sigma factor SigF; Validated; Region: PRK05572 645657006579 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657006580 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 645657006581 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657006582 DNA binding residues [nucleotide binding] 645657006583 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 645657006584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657006585 ATP binding site [chemical binding]; other site 645657006586 Mg2+ binding site [ion binding]; other site 645657006587 G-X-G motif; other site 645657006588 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 645657006589 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 645657006590 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 645657006591 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 645657006592 purine nucleoside phosphorylase; Provisional; Region: PRK08202 645657006593 phosphopentomutase; Provisional; Region: PRK05362 645657006594 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 645657006595 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 645657006596 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 645657006597 active site 645657006598 Int/Topo IB signature motif; other site 645657006599 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 645657006600 ferric uptake regulator; Provisional; Region: fur; PRK09462 645657006601 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 645657006602 metal binding site 2 [ion binding]; metal-binding site 645657006603 putative DNA binding helix; other site 645657006604 metal binding site 1 [ion binding]; metal-binding site 645657006605 dimer interface [polypeptide binding]; other site 645657006606 structural Zn2+ binding site [ion binding]; other site 645657006607 stage II sporulation protein M; Region: spo_II_M; TIGR02831 645657006608 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 645657006609 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 645657006610 Malic enzyme, N-terminal domain; Region: malic; pfam00390 645657006611 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 645657006612 NAD(P) binding pocket [chemical binding]; other site 645657006613 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 645657006614 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 645657006615 Aspartase; Region: Aspartase; cd01357 645657006616 active sites [active] 645657006617 tetramer interface [polypeptide binding]; other site 645657006618 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 645657006619 active site 645657006620 homodimer interface [polypeptide binding]; other site 645657006621 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645657006622 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657006623 non-specific DNA binding site [nucleotide binding]; other site 645657006624 salt bridge; other site 645657006625 sequence-specific DNA binding site [nucleotide binding]; other site 645657006626 TIGR00375 family protein; Region: TIGR00375 645657006627 PHP-associated; Region: PHP_C; pfam13263 645657006628 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 645657006629 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 645657006630 dimer interface [polypeptide binding]; other site 645657006631 ADP-ribose binding site [chemical binding]; other site 645657006632 active site 645657006633 nudix motif; other site 645657006634 metal binding site [ion binding]; metal-binding site 645657006635 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 645657006636 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645657006637 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645657006638 active site 645657006639 catalytic tetrad [active] 645657006640 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 645657006641 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 645657006642 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 645657006643 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 645657006644 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 645657006645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 645657006646 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 645657006647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657006648 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645657006649 Coenzyme A binding pocket [chemical binding]; other site 645657006650 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 645657006651 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 645657006652 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 645657006653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657006654 Coenzyme A binding pocket [chemical binding]; other site 645657006655 YolD-like protein; Region: YolD; pfam08863 645657006656 DNA polymerase IV; Reviewed; Region: PRK03103 645657006657 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 645657006658 active site 645657006659 DNA binding site [nucleotide binding] 645657006660 YqzH-like protein; Region: YqzH; pfam14164 645657006661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657006662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657006663 putative substrate translocation pore; other site 645657006664 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 645657006665 putative dimer interface [polypeptide binding]; other site 645657006666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657006667 ligand binding site [chemical binding]; other site 645657006668 Zn binding site [ion binding]; other site 645657006669 pantothenate kinase; Provisional; Region: PRK05439 645657006670 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 645657006671 ATP-binding site [chemical binding]; other site 645657006672 CoA-binding site [chemical binding]; other site 645657006673 Mg2+-binding site [ion binding]; other site 645657006674 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 645657006675 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 645657006676 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645657006677 catalytic residue [active] 645657006678 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 645657006679 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 645657006680 NADP binding site [chemical binding]; other site 645657006681 homodimer interface [polypeptide binding]; other site 645657006682 substrate binding site [chemical binding]; other site 645657006683 active site 645657006684 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 645657006685 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 645657006686 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 645657006687 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 645657006688 putative metal binding site [ion binding]; other site 645657006689 putative dimer interface [polypeptide binding]; other site 645657006690 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 645657006691 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 645657006692 active site 645657006693 FMN binding site [chemical binding]; other site 645657006694 substrate binding site [chemical binding]; other site 645657006695 homotetramer interface [polypeptide binding]; other site 645657006696 catalytic residue [active] 645657006697 Transposase domain (DUF772); Region: DUF772; pfam05598 645657006698 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 645657006699 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 645657006700 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 645657006701 putative hydrolase; Provisional; Region: PRK02113 645657006702 ribonuclease Z; Region: RNase_Z; TIGR02651 645657006703 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 645657006704 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 645657006705 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 645657006706 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 645657006707 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 645657006708 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 645657006709 DNA polymerase IV; Validated; Region: PRK01810 645657006710 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 645657006711 active site 645657006712 DNA binding site [nucleotide binding] 645657006713 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 645657006714 OxaA-like protein precursor; Validated; Region: PRK01622 645657006715 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 645657006716 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 645657006717 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 645657006718 peptidase T-like protein; Region: PepT-like; TIGR01883 645657006719 metal binding site [ion binding]; metal-binding site 645657006720 putative dimer interface [polypeptide binding]; other site 645657006721 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 645657006722 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 645657006723 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 645657006724 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 645657006725 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657006726 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 645657006727 dimer interface [polypeptide binding]; other site 645657006728 substrate binding site [chemical binding]; other site 645657006729 metal binding site [ion binding]; metal-binding site 645657006730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 645657006731 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 645657006732 Predicted membrane protein [Function unknown]; Region: COG4129 645657006733 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 645657006734 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 645657006735 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 645657006736 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 645657006737 Walker A/P-loop; other site 645657006738 ATP binding site [chemical binding]; other site 645657006739 Q-loop/lid; other site 645657006740 ABC transporter signature motif; other site 645657006741 Walker B; other site 645657006742 D-loop; other site 645657006743 H-loop/switch region; other site 645657006744 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 645657006745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657006746 dimer interface [polypeptide binding]; other site 645657006747 conserved gate region; other site 645657006748 putative PBP binding loops; other site 645657006749 ABC-ATPase subunit interface; other site 645657006750 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645657006751 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645657006752 substrate binding pocket [chemical binding]; other site 645657006753 membrane-bound complex binding site; other site 645657006754 hinge residues; other site 645657006755 Disulphide isomerase; Region: Disulph_isomer; pfam06491 645657006756 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 645657006757 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 645657006758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657006759 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657006760 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 645657006761 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 645657006762 DNA binding residues [nucleotide binding] 645657006763 drug binding residues [chemical binding]; other site 645657006764 dimer interface [polypeptide binding]; other site 645657006765 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 645657006766 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 645657006767 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 645657006768 E3 interaction surface; other site 645657006769 lipoyl attachment site [posttranslational modification]; other site 645657006770 e3 binding domain; Region: E3_binding; pfam02817 645657006771 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 645657006772 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 645657006773 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 645657006774 alpha subunit interface [polypeptide binding]; other site 645657006775 TPP binding site [chemical binding]; other site 645657006776 heterodimer interface [polypeptide binding]; other site 645657006777 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 645657006778 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 645657006779 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 645657006780 tetramer interface [polypeptide binding]; other site 645657006781 TPP-binding site [chemical binding]; other site 645657006782 heterodimer interface [polypeptide binding]; other site 645657006783 phosphorylation loop region [posttranslational modification] 645657006784 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 645657006785 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 645657006786 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645657006787 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 645657006788 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645657006789 nucleotide binding site [chemical binding]; other site 645657006790 Acetokinase family; Region: Acetate_kinase; cl17229 645657006791 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 645657006792 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 645657006793 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 645657006794 NAD binding site [chemical binding]; other site 645657006795 Phe binding site; other site 645657006796 phosphate butyryltransferase; Validated; Region: PRK07742 645657006797 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 645657006798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657006799 putative active site [active] 645657006800 heme pocket [chemical binding]; other site 645657006801 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657006802 putative active site [active] 645657006803 heme pocket [chemical binding]; other site 645657006804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657006805 Walker A motif; other site 645657006806 ATP binding site [chemical binding]; other site 645657006807 Walker B motif; other site 645657006808 arginine finger; other site 645657006809 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 645657006810 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 645657006811 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 645657006812 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 645657006813 tetramer interface [polypeptide binding]; other site 645657006814 active site 645657006815 Mg2+/Mn2+ binding site [ion binding]; other site 645657006816 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 645657006817 2-methylcitrate dehydratase; Region: prpD; TIGR02330 645657006818 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 645657006819 dimer interface [polypeptide binding]; other site 645657006820 Citrate synthase; Region: Citrate_synt; pfam00285 645657006821 active site 645657006822 coenzyme A binding site [chemical binding]; other site 645657006823 citrylCoA binding site [chemical binding]; other site 645657006824 oxalacetate/citrate binding site [chemical binding]; other site 645657006825 catalytic triad [active] 645657006826 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 645657006827 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 645657006828 FAD binding site [chemical binding]; other site 645657006829 homotetramer interface [polypeptide binding]; other site 645657006830 substrate binding pocket [chemical binding]; other site 645657006831 catalytic base [active] 645657006832 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 645657006833 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 645657006834 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 645657006835 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 645657006836 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 645657006837 dimer interface [polypeptide binding]; other site 645657006838 active site 645657006839 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 645657006840 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 645657006841 active site 645657006842 catalytic site [active] 645657006843 metal binding site [ion binding]; metal-binding site 645657006844 dimer interface [polypeptide binding]; other site 645657006845 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 645657006846 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645657006847 active site 645657006848 metal binding site [ion binding]; metal-binding site 645657006849 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 645657006850 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 645657006851 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 645657006852 putative active site [active] 645657006853 putative FMN binding site [chemical binding]; other site 645657006854 putative substrate binding site [chemical binding]; other site 645657006855 putative catalytic residue [active] 645657006856 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 645657006857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657006858 active site 645657006859 phosphorylation site [posttranslational modification] 645657006860 intermolecular recognition site; other site 645657006861 dimerization interface [polypeptide binding]; other site 645657006862 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 645657006863 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 645657006864 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 645657006865 protein binding site [polypeptide binding]; other site 645657006866 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 645657006867 DNA repair protein RecN; Region: recN; TIGR00634 645657006868 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 645657006869 Walker A/P-loop; other site 645657006870 ATP binding site [chemical binding]; other site 645657006871 Q-loop/lid; other site 645657006872 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 645657006873 ABC transporter signature motif; other site 645657006874 Walker B; other site 645657006875 D-loop; other site 645657006876 H-loop/switch region; other site 645657006877 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 645657006878 arginine repressor; Provisional; Region: PRK04280 645657006879 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 645657006880 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 645657006881 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 645657006882 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 645657006883 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 645657006884 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 645657006885 TPP-binding site; other site 645657006886 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 645657006887 PYR/PP interface [polypeptide binding]; other site 645657006888 dimer interface [polypeptide binding]; other site 645657006889 TPP binding site [chemical binding]; other site 645657006890 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 645657006891 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 645657006892 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 645657006893 substrate binding pocket [chemical binding]; other site 645657006894 chain length determination region; other site 645657006895 substrate-Mg2+ binding site; other site 645657006896 catalytic residues [active] 645657006897 aspartate-rich region 1; other site 645657006898 active site lid residues [active] 645657006899 aspartate-rich region 2; other site 645657006900 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 645657006901 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 645657006902 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 645657006903 generic binding surface II; other site 645657006904 generic binding surface I; other site 645657006905 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 645657006906 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 645657006907 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 645657006908 homodimer interface [polypeptide binding]; other site 645657006909 NADP binding site [chemical binding]; other site 645657006910 substrate binding site [chemical binding]; other site 645657006911 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 645657006912 putative RNA binding site [nucleotide binding]; other site 645657006913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 645657006914 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 645657006915 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645657006916 ATP-grasp domain; Region: ATP-grasp_4; cl17255 645657006917 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 645657006918 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 645657006919 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 645657006920 carboxyltransferase (CT) interaction site; other site 645657006921 biotinylation site [posttranslational modification]; other site 645657006922 Transposase domain (DUF772); Region: DUF772; pfam05598 645657006923 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 645657006924 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 645657006925 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 645657006926 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 645657006927 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 645657006928 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 645657006929 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 645657006930 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 645657006931 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 645657006932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657006933 Walker A motif; other site 645657006934 ATP binding site [chemical binding]; other site 645657006935 Walker B motif; other site 645657006936 arginine finger; other site 645657006937 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 645657006938 elongation factor P; Validated; Region: PRK00529 645657006939 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 645657006940 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 645657006941 RNA binding site [nucleotide binding]; other site 645657006942 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 645657006943 RNA binding site [nucleotide binding]; other site 645657006944 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 645657006945 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 645657006946 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 645657006947 active site 645657006948 Dehydroquinase class II; Region: DHquinase_II; pfam01220 645657006949 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 645657006950 trimer interface [polypeptide binding]; other site 645657006951 active site 645657006952 dimer interface [polypeptide binding]; other site 645657006953 Conserved membrane protein YqhR; Region: YqhR; pfam11085 645657006954 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 645657006955 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 645657006956 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 645657006957 active site 645657006958 nucleophile elbow; other site 645657006959 manganese transport transcriptional regulator; Provisional; Region: PRK03902 645657006960 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 645657006961 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 645657006962 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 645657006963 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 645657006964 active site residue [active] 645657006965 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 645657006966 tetramer interface [polypeptide binding]; other site 645657006967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657006968 catalytic residue [active] 645657006969 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 645657006970 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 645657006971 tetramer interface [polypeptide binding]; other site 645657006972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657006973 catalytic residue [active] 645657006974 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 645657006975 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 645657006976 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 645657006977 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 645657006978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645657006979 ATP binding site [chemical binding]; other site 645657006980 putative Mg++ binding site [ion binding]; other site 645657006981 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657006982 nucleotide binding region [chemical binding]; other site 645657006983 ATP-binding site [chemical binding]; other site 645657006984 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 645657006985 Anti-repressor SinI; Region: SinI; pfam08671 645657006986 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645657006987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657006988 non-specific DNA binding site [nucleotide binding]; other site 645657006989 salt bridge; other site 645657006990 sequence-specific DNA binding site [nucleotide binding]; other site 645657006991 Anti-repressor SinI; Region: SinI; pfam08671 645657006992 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 645657006993 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 645657006994 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 645657006995 Catalytic site [active] 645657006996 YqxM protein; Region: YqxM_for_SipW; TIGR04087 645657006997 Merozoite surface protein (SPAM); Region: Merozoite_SPAM; pfam07133 645657006998 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 645657006999 YqzE-like protein; Region: YqzE; pfam14038 645657007000 ComG operon protein 7; Region: ComGG; pfam14173 645657007001 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 645657007002 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 645657007003 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 645657007004 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 645657007005 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 645657007006 Type II/IV secretion system protein; Region: T2SE; pfam00437 645657007007 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 645657007008 Walker A motif; other site 645657007009 ATP binding site [chemical binding]; other site 645657007010 Walker B motif; other site 645657007011 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 645657007012 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 645657007013 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 645657007014 Cl binding site [ion binding]; other site 645657007015 oligomer interface [polypeptide binding]; other site 645657007016 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 645657007017 Domain of unknown function DUF21; Region: DUF21; pfam01595 645657007018 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 645657007019 Transporter associated domain; Region: CorC_HlyC; smart01091 645657007020 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 645657007021 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 645657007022 ArsC family; Region: ArsC; pfam03960 645657007023 putative catalytic residues [active] 645657007024 thiol/disulfide switch; other site 645657007025 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 645657007026 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645657007027 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 645657007028 Uncharacterized conserved protein [Function unknown]; Region: COG0011 645657007029 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 645657007030 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 645657007031 putative active site [active] 645657007032 Zn binding site [ion binding]; other site 645657007033 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 645657007034 Sulfatase; Region: Sulfatase; pfam00884 645657007035 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 645657007036 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645657007037 nucleotide binding site [chemical binding]; other site 645657007038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 645657007039 Rhomboid family; Region: Rhomboid; pfam01694 645657007040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657007041 binding surface 645657007042 Tetratricopeptide repeat; Region: TPR_16; pfam13432 645657007043 TPR motif; other site 645657007044 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 645657007045 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 645657007046 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 645657007047 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 645657007048 YceG-like family; Region: YceG; pfam02618 645657007049 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 645657007050 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 645657007051 Walker A/P-loop; other site 645657007052 ATP binding site [chemical binding]; other site 645657007053 Q-loop/lid; other site 645657007054 ABC transporter signature motif; other site 645657007055 Walker B; other site 645657007056 D-loop; other site 645657007057 H-loop/switch region; other site 645657007058 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 645657007059 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 645657007060 Walker A/P-loop; other site 645657007061 ATP binding site [chemical binding]; other site 645657007062 Q-loop/lid; other site 645657007063 ABC transporter signature motif; other site 645657007064 Walker B; other site 645657007065 D-loop; other site 645657007066 H-loop/switch region; other site 645657007067 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 645657007068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657007069 dimer interface [polypeptide binding]; other site 645657007070 conserved gate region; other site 645657007071 ABC-ATPase subunit interface; other site 645657007072 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 645657007073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657007074 dimer interface [polypeptide binding]; other site 645657007075 conserved gate region; other site 645657007076 putative PBP binding loops; other site 645657007077 ABC-ATPase subunit interface; other site 645657007078 PBP superfamily domain; Region: PBP_like_2; cl17296 645657007079 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 645657007080 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 645657007081 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 645657007082 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645657007083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657007084 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657007085 putative substrate translocation pore; other site 645657007086 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 645657007087 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 645657007088 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 645657007089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 645657007090 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 645657007091 Lysin motif; Region: LysM; smart00257 645657007092 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 645657007093 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 645657007094 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 645657007095 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 645657007096 Uncharacterized conserved protein [Function unknown]; Region: COG5663 645657007097 ferric uptake regulator; Provisional; Region: fur; PRK09462 645657007098 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 645657007099 metal binding site 2 [ion binding]; metal-binding site 645657007100 putative DNA binding helix; other site 645657007101 metal binding site 1 [ion binding]; metal-binding site 645657007102 dimer interface [polypeptide binding]; other site 645657007103 structural Zn2+ binding site [ion binding]; other site 645657007104 Uncharacterized conserved protein [Function unknown]; Region: COG1284 645657007105 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645657007106 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645657007107 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 645657007108 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 645657007109 endonuclease IV; Provisional; Region: PRK01060 645657007110 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 645657007111 AP (apurinic/apyrimidinic) site pocket; other site 645657007112 DNA interaction; other site 645657007113 Metal-binding active site; metal-binding site 645657007114 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 645657007115 DEAD-like helicases superfamily; Region: DEXDc; smart00487 645657007116 ATP binding site [chemical binding]; other site 645657007117 Mg++ binding site [ion binding]; other site 645657007118 motif III; other site 645657007119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657007120 nucleotide binding region [chemical binding]; other site 645657007121 ATP-binding site [chemical binding]; other site 645657007122 YqfQ-like protein; Region: YqfQ; pfam14181 645657007123 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 645657007124 LytB protein; Region: LYTB; pfam02401 645657007125 Uncharacterized conserved protein [Function unknown]; Region: COG0327 645657007126 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 645657007127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 645657007128 Uncharacterized conserved protein [Function unknown]; Region: COG0327 645657007129 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 645657007130 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 645657007131 Family of unknown function (DUF633); Region: DUF633; pfam04816 645657007132 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 645657007133 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 645657007134 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 645657007135 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 645657007136 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 645657007137 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657007138 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 645657007139 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657007140 DNA binding residues [nucleotide binding] 645657007141 DNA primase; Validated; Region: dnaG; PRK05667 645657007142 CHC2 zinc finger; Region: zf-CHC2; pfam01807 645657007143 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 645657007144 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 645657007145 active site 645657007146 metal binding site [ion binding]; metal-binding site 645657007147 interdomain interaction site; other site 645657007148 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 645657007149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 645657007150 PEP synthetase regulatory protein; Provisional; Region: PRK05339 645657007151 HTH domain; Region: HTH_11; pfam08279 645657007152 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 645657007153 FOG: CBS domain [General function prediction only]; Region: COG0517 645657007154 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 645657007155 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 645657007156 dimer interface [polypeptide binding]; other site 645657007157 motif 1; other site 645657007158 active site 645657007159 motif 2; other site 645657007160 motif 3; other site 645657007161 Recombination protein O N terminal; Region: RecO_N; pfam11967 645657007162 DNA repair protein RecO; Region: reco; TIGR00613 645657007163 Recombination protein O C terminal; Region: RecO_C; pfam02565 645657007164 YqzL-like protein; Region: YqzL; pfam14006 645657007165 GTPase Era; Reviewed; Region: era; PRK00089 645657007166 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 645657007167 G1 box; other site 645657007168 GTP/Mg2+ binding site [chemical binding]; other site 645657007169 Switch I region; other site 645657007170 G2 box; other site 645657007171 Switch II region; other site 645657007172 G3 box; other site 645657007173 G4 box; other site 645657007174 G5 box; other site 645657007175 KH domain; Region: KH_2; pfam07650 645657007176 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 645657007177 active site 645657007178 catalytic motif [active] 645657007179 Zn binding site [ion binding]; other site 645657007180 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 645657007181 metal-binding heat shock protein; Provisional; Region: PRK00016 645657007182 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 645657007183 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 645657007184 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645657007185 Zn2+ binding site [ion binding]; other site 645657007186 Mg2+ binding site [ion binding]; other site 645657007187 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 645657007188 PhoH-like protein; Region: PhoH; pfam02562 645657007189 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 645657007190 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 645657007191 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 645657007192 hypothetical protein; Provisional; Region: PRK13665 645657007193 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 645657007194 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 645657007195 dimer interface [polypeptide binding]; other site 645657007196 active site residues [active] 645657007197 Yqey-like protein; Region: YqeY; pfam09424 645657007198 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 645657007199 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 645657007200 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 645657007201 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 645657007202 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 645657007203 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 645657007204 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645657007205 FeS/SAM binding site; other site 645657007206 TRAM domain; Region: TRAM; cl01282 645657007207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 645657007208 RNA methyltransferase, RsmE family; Region: TIGR00046 645657007209 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 645657007210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657007211 S-adenosylmethionine binding site [chemical binding]; other site 645657007212 chaperone protein DnaJ; Provisional; Region: PRK14280 645657007213 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 645657007214 HSP70 interaction site [polypeptide binding]; other site 645657007215 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 645657007216 substrate binding site [polypeptide binding]; other site 645657007217 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 645657007218 Zn binding sites [ion binding]; other site 645657007219 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 645657007220 dimer interface [polypeptide binding]; other site 645657007221 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 645657007222 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 645657007223 nucleotide binding site [chemical binding]; other site 645657007224 NEF interaction site [polypeptide binding]; other site 645657007225 SBD interface [polypeptide binding]; other site 645657007226 heat shock protein GrpE; Provisional; Region: PRK14140 645657007227 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 645657007228 dimer interface [polypeptide binding]; other site 645657007229 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 645657007230 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 645657007231 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 645657007232 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 645657007233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645657007234 FeS/SAM binding site; other site 645657007235 HemN C-terminal domain; Region: HemN_C; pfam06969 645657007236 GTP-binding protein LepA; Provisional; Region: PRK05433 645657007237 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 645657007238 G1 box; other site 645657007239 putative GEF interaction site [polypeptide binding]; other site 645657007240 GTP/Mg2+ binding site [chemical binding]; other site 645657007241 Switch I region; other site 645657007242 G2 box; other site 645657007243 G3 box; other site 645657007244 Switch II region; other site 645657007245 G4 box; other site 645657007246 G5 box; other site 645657007247 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 645657007248 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 645657007249 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 645657007250 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 645657007251 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 645657007252 stage II sporulation protein P; Region: spore_II_P; TIGR02867 645657007253 germination protease; Provisional; Region: PRK02858 645657007254 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 645657007255 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 645657007256 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 645657007257 YqzM-like protein; Region: YqzM; pfam14141 645657007258 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 645657007259 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 645657007260 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 645657007261 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645657007262 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 645657007263 catalytic motif [active] 645657007264 Zn binding site [ion binding]; other site 645657007265 SLBB domain; Region: SLBB; pfam10531 645657007266 comEA protein; Region: comE; TIGR01259 645657007267 Helix-hairpin-helix motif; Region: HHH; pfam00633 645657007268 late competence protein ComER; Validated; Region: PRK07680 645657007269 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 645657007270 Methyltransferase domain; Region: Methyltransf_31; pfam13847 645657007271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657007272 S-adenosylmethionine binding site [chemical binding]; other site 645657007273 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 645657007274 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645657007275 Zn2+ binding site [ion binding]; other site 645657007276 Mg2+ binding site [ion binding]; other site 645657007277 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 645657007278 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 645657007279 active site 645657007280 (T/H)XGH motif; other site 645657007281 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 645657007282 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 645657007283 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 645657007284 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 645657007285 shikimate binding site; other site 645657007286 NAD(P) binding site [chemical binding]; other site 645657007287 GTPase YqeH; Provisional; Region: PRK13796 645657007288 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 645657007289 GTP/Mg2+ binding site [chemical binding]; other site 645657007290 G4 box; other site 645657007291 G5 box; other site 645657007292 G1 box; other site 645657007293 Switch I region; other site 645657007294 G2 box; other site 645657007295 G3 box; other site 645657007296 Switch II region; other site 645657007297 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 645657007298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657007299 active site 645657007300 motif I; other site 645657007301 motif II; other site 645657007302 Sporulation inhibitor A; Region: Sda; pfam08970 645657007303 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 645657007304 active site 645657007305 catalytic triad [active] 645657007306 oxyanion hole [active] 645657007307 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 645657007308 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 645657007309 amidase catalytic site [active] 645657007310 Zn binding residues [ion binding]; other site 645657007311 substrate binding site [chemical binding]; other site 645657007312 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 645657007313 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 645657007314 Uncharacterized conserved protein [Function unknown]; Region: COG0398 645657007315 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 645657007316 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 645657007317 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 645657007318 arginine decarboxylase; Provisional; Region: PRK15029 645657007319 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 645657007320 sporulation sigma factor SigK; Reviewed; Region: PRK05803 645657007321 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657007322 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657007323 DNA binding residues [nucleotide binding] 645657007324 fumarate hydratase; Reviewed; Region: fumC; PRK00485 645657007325 Class II fumarases; Region: Fumarase_classII; cd01362 645657007326 active site 645657007327 tetramer interface [polypeptide binding]; other site 645657007328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657007329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657007330 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 645657007331 putative dimerization interface [polypeptide binding]; other site 645657007332 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 645657007333 dimer interface [polypeptide binding]; other site 645657007334 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657007335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 645657007336 binding surface 645657007337 TPR motif; other site 645657007338 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657007339 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657007340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657007341 binding surface 645657007342 TPR motif; other site 645657007343 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657007344 Uncharacterized conserved protein [Function unknown]; Region: COG5444 645657007345 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 645657007346 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 645657007347 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 645657007348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 645657007349 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 645657007350 DNA-binding interface [nucleotide binding]; DNA binding site 645657007351 Integrase core domain; Region: rve; pfam00665 645657007352 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 645657007353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657007354 Walker A motif; other site 645657007355 ATP binding site [chemical binding]; other site 645657007356 Walker B motif; other site 645657007357 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 645657007358 Uncharacterized conserved protein [Function unknown]; Region: COG5484 645657007359 Phage terminase small subunit; Region: Phage_terminase; pfam10668 645657007360 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645657007361 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 645657007362 DNA binding residues [nucleotide binding] 645657007363 dimer interface [polypeptide binding]; other site 645657007364 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 645657007365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657007366 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657007367 putative substrate translocation pore; other site 645657007368 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 645657007369 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 645657007370 Coenzyme A binding pocket [chemical binding]; other site 645657007371 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 645657007372 Domain of unknown function DUF21; Region: DUF21; pfam01595 645657007373 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 645657007374 Transporter associated domain; Region: CorC_HlyC; smart01091 645657007375 YrzO-like protein; Region: YrzO; pfam14142 645657007376 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 645657007377 EamA-like transporter family; Region: EamA; pfam00892 645657007378 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657007379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657007380 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 645657007381 putative dimerization interface [polypeptide binding]; other site 645657007382 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 645657007383 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 645657007384 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 645657007385 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 645657007386 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 645657007387 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 645657007388 AzlC protein; Region: AzlC; cl00570 645657007389 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 645657007390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657007391 putative DNA binding site [nucleotide binding]; other site 645657007392 dimerization interface [polypeptide binding]; other site 645657007393 putative Zn2+ binding site [ion binding]; other site 645657007394 AsnC family; Region: AsnC_trans_reg; pfam01037 645657007395 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 645657007396 RNAase interaction site [polypeptide binding]; other site 645657007397 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 645657007398 Cytochrome P450; Region: p450; cl12078 645657007399 Isochorismatase family; Region: Isochorismatase; pfam00857 645657007400 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 645657007401 catalytic triad [active] 645657007402 conserved cis-peptide bond; other site 645657007403 DinB family; Region: DinB; pfam05163 645657007404 DinB superfamily; Region: DinB_2; pfam12867 645657007405 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 645657007406 Nitronate monooxygenase; Region: NMO; pfam03060 645657007407 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 645657007408 FMN binding site [chemical binding]; other site 645657007409 substrate binding site [chemical binding]; other site 645657007410 putative catalytic residue [active] 645657007411 glutamate racemase; Region: glut_race; TIGR00067 645657007412 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 645657007413 putative binding site; other site 645657007414 putative dimer interface [polypeptide binding]; other site 645657007415 YodA lipocalin-like domain; Region: YodA; pfam09223 645657007416 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 645657007417 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657007418 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657007419 DNA binding residues [nucleotide binding] 645657007420 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645657007421 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645657007422 active site 645657007423 catalytic tetrad [active] 645657007424 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 645657007425 chitosan binding site [chemical binding]; other site 645657007426 catalytic residues [active] 645657007427 Mor transcription activator family; Region: Mor; cl02360 645657007428 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 645657007429 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 645657007430 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 645657007431 Bacterial SH3 domain homologues; Region: SH3b; smart00287 645657007432 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 645657007433 Bacterial SH3 domain; Region: SH3_3; cl17532 645657007434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657007435 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 645657007436 active site 645657007437 metal binding site [ion binding]; metal-binding site 645657007438 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 645657007439 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 645657007440 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 645657007441 NAD binding site [chemical binding]; other site 645657007442 catalytic Zn binding site [ion binding]; other site 645657007443 structural Zn binding site [ion binding]; other site 645657007444 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 645657007445 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645657007446 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 645657007447 DNA binding residues [nucleotide binding] 645657007448 putative dimer interface [polypeptide binding]; other site 645657007449 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 645657007450 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 645657007451 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 645657007452 putative NAD(P) binding site [chemical binding]; other site 645657007453 putative substrate binding site [chemical binding]; other site 645657007454 catalytic Zn binding site [ion binding]; other site 645657007455 structural Zn binding site [ion binding]; other site 645657007456 dimer interface [polypeptide binding]; other site 645657007457 intracellular protease, PfpI family; Region: PfpI; TIGR01382 645657007458 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 645657007459 proposed catalytic triad [active] 645657007460 conserved cys residue [active] 645657007461 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 645657007462 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 645657007463 substrate binding [chemical binding]; other site 645657007464 active site 645657007465 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 645657007466 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 645657007467 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 645657007468 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 645657007469 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 645657007470 active site 645657007471 phosphorylation site [posttranslational modification] 645657007472 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 645657007473 active pocket/dimerization site; other site 645657007474 active site 645657007475 phosphorylation site [posttranslational modification] 645657007476 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 645657007477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657007478 Walker A motif; other site 645657007479 ATP binding site [chemical binding]; other site 645657007480 Walker B motif; other site 645657007481 arginine finger; other site 645657007482 Transcriptional antiterminator [Transcription]; Region: COG3933 645657007483 PRD domain; Region: PRD; pfam00874 645657007484 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 645657007485 active pocket/dimerization site; other site 645657007486 active site 645657007487 phosphorylation site [posttranslational modification] 645657007488 PRD domain; Region: PRD; pfam00874 645657007489 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 645657007490 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 645657007491 Predicted transcriptional regulators [Transcription]; Region: COG1378 645657007492 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 645657007493 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 645657007494 C-terminal domain interface [polypeptide binding]; other site 645657007495 sugar binding site [chemical binding]; other site 645657007496 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 645657007497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657007498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657007499 DNA binding residues [nucleotide binding] 645657007500 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 645657007501 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 645657007502 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 645657007503 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 645657007504 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 645657007505 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 645657007506 catalytic triad [active] 645657007507 catalytic triad [active] 645657007508 oxyanion hole [active] 645657007509 YrhK-like protein; Region: YrhK; pfam14145 645657007510 Cytochrome P450; Region: p450; cl12078 645657007511 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 645657007512 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 645657007513 Flavodoxin; Region: Flavodoxin_1; pfam00258 645657007514 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 645657007515 FAD binding pocket [chemical binding]; other site 645657007516 FAD binding motif [chemical binding]; other site 645657007517 catalytic residues [active] 645657007518 NAD binding pocket [chemical binding]; other site 645657007519 phosphate binding motif [ion binding]; other site 645657007520 beta-alpha-beta structure motif; other site 645657007521 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 645657007522 Cytochrome P450; Region: p450; cl12078 645657007523 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657007524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657007525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657007526 S-adenosylmethionine binding site [chemical binding]; other site 645657007527 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 645657007528 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 645657007529 Uncharacterized conserved protein [Function unknown]; Region: COG5609 645657007530 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 645657007531 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 645657007532 catalytic loop [active] 645657007533 iron binding site [ion binding]; other site 645657007534 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 645657007535 4Fe-4S binding domain; Region: Fer4; pfam00037 645657007536 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 645657007537 [4Fe-4S] binding site [ion binding]; other site 645657007538 molybdopterin cofactor binding site; other site 645657007539 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 645657007540 molybdopterin cofactor binding site; other site 645657007541 Uncharacterized conserved protein [Function unknown]; Region: COG2427 645657007542 Transposase domain (DUF772); Region: DUF772; pfam05598 645657007543 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 645657007544 YrhC-like protein; Region: YrhC; pfam14143 645657007545 cystathionine beta-lyase; Provisional; Region: PRK07671 645657007546 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 645657007547 homodimer interface [polypeptide binding]; other site 645657007548 substrate-cofactor binding pocket; other site 645657007549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657007550 catalytic residue [active] 645657007551 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 645657007552 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 645657007553 dimer interface [polypeptide binding]; other site 645657007554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657007555 catalytic residue [active] 645657007556 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 645657007557 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 645657007558 Methyltransferase domain; Region: Methyltransf_23; pfam13489 645657007559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657007560 S-adenosylmethionine binding site [chemical binding]; other site 645657007561 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 645657007562 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 645657007563 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 645657007564 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 645657007565 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645657007566 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 645657007567 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 645657007568 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 645657007569 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 645657007570 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 645657007571 ATP-binding site [chemical binding]; other site 645657007572 Sugar specificity; other site 645657007573 Pyrimidine base specificity; other site 645657007574 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 645657007575 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 645657007576 Peptidase family U32; Region: Peptidase_U32; pfam01136 645657007577 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 645657007578 Peptidase family U32; Region: Peptidase_U32; pfam01136 645657007579 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 645657007580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657007581 S-adenosylmethionine binding site [chemical binding]; other site 645657007582 conserved hypothetical protein, YceG family; Region: TIGR00247 645657007583 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 645657007584 dimerization interface [polypeptide binding]; other site 645657007585 hypothetical protein; Provisional; Region: PRK13678 645657007586 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 645657007587 hypothetical protein; Provisional; Region: PRK05473 645657007588 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 645657007589 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 645657007590 motif 1; other site 645657007591 active site 645657007592 motif 2; other site 645657007593 motif 3; other site 645657007594 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 645657007595 DHHA1 domain; Region: DHHA1; pfam02272 645657007596 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 645657007597 Domain of unknown function DUF20; Region: UPF0118; pfam01594 645657007598 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 645657007599 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 645657007600 Walker A/P-loop; other site 645657007601 ATP binding site [chemical binding]; other site 645657007602 Q-loop/lid; other site 645657007603 ABC transporter signature motif; other site 645657007604 Walker B; other site 645657007605 D-loop; other site 645657007606 H-loop/switch region; other site 645657007607 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 645657007608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645657007609 substrate binding pocket [chemical binding]; other site 645657007610 membrane-bound complex binding site; other site 645657007611 hinge residues; other site 645657007612 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 645657007613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657007614 dimer interface [polypeptide binding]; other site 645657007615 conserved gate region; other site 645657007616 putative PBP binding loops; other site 645657007617 ABC-ATPase subunit interface; other site 645657007618 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 645657007619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657007620 dimer interface [polypeptide binding]; other site 645657007621 ABC-ATPase subunit interface; other site 645657007622 putative PBP binding loops; other site 645657007623 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 645657007624 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 645657007625 PRC-barrel domain; Region: PRC; pfam05239 645657007626 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 645657007627 AAA domain; Region: AAA_30; pfam13604 645657007628 Family description; Region: UvrD_C_2; pfam13538 645657007629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657007630 binding surface 645657007631 TPR motif; other site 645657007632 TPR repeat; Region: TPR_11; pfam13414 645657007633 TPR repeat; Region: TPR_11; pfam13414 645657007634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657007635 binding surface 645657007636 TPR motif; other site 645657007637 TPR repeat; Region: TPR_11; pfam13414 645657007638 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 645657007639 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 645657007640 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 645657007641 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 645657007642 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645657007643 catalytic residue [active] 645657007644 Predicted transcriptional regulator [Transcription]; Region: COG1959 645657007645 Transcriptional regulator; Region: Rrf2; pfam02082 645657007646 recombination factor protein RarA; Reviewed; Region: PRK13342 645657007647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657007648 Walker A motif; other site 645657007649 ATP binding site [chemical binding]; other site 645657007650 Walker B motif; other site 645657007651 arginine finger; other site 645657007652 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 645657007653 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 645657007654 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 645657007655 putative ATP binding site [chemical binding]; other site 645657007656 putative substrate interface [chemical binding]; other site 645657007657 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 645657007658 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 645657007659 dimer interface [polypeptide binding]; other site 645657007660 anticodon binding site; other site 645657007661 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 645657007662 homodimer interface [polypeptide binding]; other site 645657007663 motif 1; other site 645657007664 active site 645657007665 motif 2; other site 645657007666 GAD domain; Region: GAD; pfam02938 645657007667 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 645657007668 motif 3; other site 645657007669 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 645657007670 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 645657007671 dimer interface [polypeptide binding]; other site 645657007672 motif 1; other site 645657007673 active site 645657007674 motif 2; other site 645657007675 motif 3; other site 645657007676 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 645657007677 anticodon binding site; other site 645657007678 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 645657007679 Bacterial SH3 domain homologues; Region: SH3b; smart00287 645657007680 Bacterial SH3 domain; Region: SH3_3; pfam08239 645657007681 Bacterial SH3 domain; Region: SH3_3; pfam08239 645657007682 Bacterial SH3 domain homologues; Region: SH3b; smart00287 645657007683 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 645657007684 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645657007685 active site 645657007686 metal binding site [ion binding]; metal-binding site 645657007687 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 645657007688 putative active site [active] 645657007689 dimerization interface [polypeptide binding]; other site 645657007690 putative tRNAtyr binding site [nucleotide binding]; other site 645657007691 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 645657007692 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645657007693 Zn2+ binding site [ion binding]; other site 645657007694 Mg2+ binding site [ion binding]; other site 645657007695 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 645657007696 synthetase active site [active] 645657007697 NTP binding site [chemical binding]; other site 645657007698 metal binding site [ion binding]; metal-binding site 645657007699 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 645657007700 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 645657007701 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645657007702 active site 645657007703 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 645657007704 DHH family; Region: DHH; pfam01368 645657007705 DHHA1 domain; Region: DHHA1; pfam02272 645657007706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 645657007707 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 645657007708 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 645657007709 TrkA-C domain; Region: TrkA_C; pfam02080 645657007710 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 645657007711 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 645657007712 Protein export membrane protein; Region: SecD_SecF; pfam02355 645657007713 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 645657007714 stage V sporulation protein B; Region: spore_V_B; TIGR02900 645657007715 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 645657007716 Predicted membrane protein [Function unknown]; Region: COG2323 645657007717 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 645657007718 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 645657007719 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 645657007720 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 645657007721 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 645657007722 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 645657007723 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 645657007724 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 645657007725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657007726 Walker A motif; other site 645657007727 ATP binding site [chemical binding]; other site 645657007728 Walker B motif; other site 645657007729 arginine finger; other site 645657007730 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 645657007731 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 645657007732 RuvA N terminal domain; Region: RuvA_N; pfam01330 645657007733 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 645657007734 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 645657007735 BofC C-terminal domain; Region: BofC_C; pfam08955 645657007736 polyol permease family; Region: 2A0118; TIGR00897 645657007737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657007738 putative substrate translocation pore; other site 645657007739 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 645657007740 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 645657007741 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 645657007742 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 645657007743 active site 645657007744 substrate binding site [chemical binding]; other site 645657007745 ATP binding site [chemical binding]; other site 645657007746 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 645657007747 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 645657007748 hypothetical protein; Validated; Region: PRK00110 645657007749 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 645657007750 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657007751 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 645657007752 quinolinate synthetase complex, A subunit; Region: nadA; TIGR00550 645657007753 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 645657007754 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 645657007755 dimerization interface [polypeptide binding]; other site 645657007756 active site 645657007757 L-aspartate oxidase; Provisional; Region: PRK08071 645657007758 L-aspartate oxidase; Provisional; Region: PRK06175 645657007759 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 645657007760 cysteine desulfurase; Provisional; Region: PRK02948 645657007761 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 645657007762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645657007763 catalytic residue [active] 645657007764 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 645657007765 HTH domain; Region: HTH_11; pfam08279 645657007766 3H domain; Region: 3H; pfam02829 645657007767 prephenate dehydratase; Provisional; Region: PRK11898 645657007768 Prephenate dehydratase; Region: PDT; pfam00800 645657007769 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 645657007770 putative L-Phe binding site [chemical binding]; other site 645657007771 hypothetical protein; Provisional; Region: PRK04435 645657007772 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 645657007773 GTPase CgtA; Reviewed; Region: obgE; PRK12297 645657007774 GTP1/OBG; Region: GTP1_OBG; pfam01018 645657007775 Obg GTPase; Region: Obg; cd01898 645657007776 G1 box; other site 645657007777 GTP/Mg2+ binding site [chemical binding]; other site 645657007778 Switch I region; other site 645657007779 G2 box; other site 645657007780 G3 box; other site 645657007781 Switch II region; other site 645657007782 G4 box; other site 645657007783 G5 box; other site 645657007784 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 645657007785 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 645657007786 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 645657007787 hypothetical protein; Provisional; Region: PRK14553 645657007788 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 645657007789 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 645657007790 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 645657007791 Peptidase family M50; Region: Peptidase_M50; pfam02163 645657007792 active site 645657007793 putative substrate binding region [chemical binding]; other site 645657007794 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 645657007795 Peptidase family M23; Region: Peptidase_M23; pfam01551 645657007796 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 645657007797 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 645657007798 Switch I; other site 645657007799 Switch II; other site 645657007800 septum formation inhibitor; Reviewed; Region: minC; PRK00513 645657007801 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 645657007802 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 645657007803 rod shape-determining protein MreC; Region: mreC; TIGR00219 645657007804 rod shape-determining protein MreC; Region: MreC; pfam04085 645657007805 rod shape-determining protein MreB; Provisional; Region: PRK13927 645657007806 MreB and similar proteins; Region: MreB_like; cd10225 645657007807 nucleotide binding site [chemical binding]; other site 645657007808 Mg binding site [ion binding]; other site 645657007809 putative protofilament interaction site [polypeptide binding]; other site 645657007810 RodZ interaction site [polypeptide binding]; other site 645657007811 hypothetical protein; Reviewed; Region: PRK00024 645657007812 Helix-hairpin-helix motif; Region: HHH; pfam00633 645657007813 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 645657007814 MPN+ (JAMM) motif; other site 645657007815 Zinc-binding site [ion binding]; other site 645657007816 Maf-like protein; Region: Maf; pfam02545 645657007817 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 645657007818 active site 645657007819 dimer interface [polypeptide binding]; other site 645657007820 Sporulation related domain; Region: SPOR; pfam05036 645657007821 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 645657007822 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 645657007823 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 645657007824 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645657007825 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645657007826 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 645657007827 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645657007828 active site 645657007829 HIGH motif; other site 645657007830 nucleotide binding site [chemical binding]; other site 645657007831 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 645657007832 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 645657007833 active site 645657007834 KMSKS motif; other site 645657007835 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 645657007836 tRNA binding surface [nucleotide binding]; other site 645657007837 anticodon binding site; other site 645657007838 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 645657007839 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 645657007840 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 645657007841 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657007842 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 645657007843 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645657007844 inhibitor-cofactor binding pocket; inhibition site 645657007845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657007846 catalytic residue [active] 645657007847 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 645657007848 dimer interface [polypeptide binding]; other site 645657007849 active site 645657007850 Schiff base residues; other site 645657007851 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 645657007852 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 645657007853 active site 645657007854 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 645657007855 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 645657007856 domain interfaces; other site 645657007857 active site 645657007858 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 645657007859 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 645657007860 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 645657007861 tRNA; other site 645657007862 putative tRNA binding site [nucleotide binding]; other site 645657007863 putative NADP binding site [chemical binding]; other site 645657007864 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 645657007865 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 645657007866 G1 box; other site 645657007867 GTP/Mg2+ binding site [chemical binding]; other site 645657007868 Switch I region; other site 645657007869 G2 box; other site 645657007870 G3 box; other site 645657007871 Switch II region; other site 645657007872 G4 box; other site 645657007873 G5 box; other site 645657007874 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 645657007875 Found in ATP-dependent protease La (LON); Region: LON; smart00464 645657007876 Found in ATP-dependent protease La (LON); Region: LON; smart00464 645657007877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657007878 Walker A motif; other site 645657007879 ATP binding site [chemical binding]; other site 645657007880 Walker B motif; other site 645657007881 arginine finger; other site 645657007882 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 645657007883 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 645657007884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657007885 Walker A motif; other site 645657007886 ATP binding site [chemical binding]; other site 645657007887 Walker B motif; other site 645657007888 arginine finger; other site 645657007889 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 645657007890 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 645657007891 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 645657007892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657007893 Walker A motif; other site 645657007894 ATP binding site [chemical binding]; other site 645657007895 Walker B motif; other site 645657007896 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 645657007897 trigger factor; Provisional; Region: tig; PRK01490 645657007898 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 645657007899 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 645657007900 TPR repeat; Region: TPR_11; pfam13414 645657007901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657007902 binding surface 645657007903 TPR motif; other site 645657007904 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 645657007905 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 645657007906 substrate binding site [chemical binding]; other site 645657007907 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 645657007908 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 645657007909 substrate binding site [chemical binding]; other site 645657007910 ligand binding site [chemical binding]; other site 645657007911 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 645657007912 tartrate dehydrogenase; Region: TTC; TIGR02089 645657007913 2-isopropylmalate synthase; Validated; Region: PRK00915 645657007914 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 645657007915 active site 645657007916 metal binding site [ion binding]; metal-binding site 645657007917 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 645657007918 ketol-acid reductoisomerase; Provisional; Region: PRK05479 645657007919 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 645657007920 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 645657007921 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 645657007922 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 645657007923 putative valine binding site [chemical binding]; other site 645657007924 dimer interface [polypeptide binding]; other site 645657007925 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 645657007926 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 645657007927 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 645657007928 PYR/PP interface [polypeptide binding]; other site 645657007929 dimer interface [polypeptide binding]; other site 645657007930 TPP binding site [chemical binding]; other site 645657007931 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 645657007932 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 645657007933 TPP-binding site [chemical binding]; other site 645657007934 dimer interface [polypeptide binding]; other site 645657007935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657007936 Coenzyme A binding pocket [chemical binding]; other site 645657007937 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 645657007938 Heat induced stress protein YflT; Region: YflT; pfam11181 645657007939 conserved domain; Region: TIGR02271 645657007940 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 645657007941 Homeodomain-like domain; Region: HTH_23; cl17451 645657007942 HTH-like domain; Region: HTH_21; pfam13276 645657007943 HTH-like domain; Region: HTH_21; pfam13276 645657007944 Integrase core domain; Region: rve; pfam00665 645657007945 Integrase core domain; Region: rve; pfam00665 645657007946 Integrase core domain; Region: rve_3; pfam13683 645657007947 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 645657007948 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 645657007949 Presynaptic Site I dimer interface [polypeptide binding]; other site 645657007950 catalytic residues [active] 645657007951 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 645657007952 Synaptic Flat tetramer interface [polypeptide binding]; other site 645657007953 Synaptic Site I dimer interface [polypeptide binding]; other site 645657007954 DNA binding site [nucleotide binding] 645657007955 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 645657007956 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 645657007957 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 645657007958 HsdM N-terminal domain; Region: HsdM_N; pfam12161 645657007959 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 645657007960 Methyltransferase domain; Region: Methyltransf_26; pfam13659 645657007961 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 645657007962 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645657007963 ATP binding site [chemical binding]; other site 645657007964 putative Mg++ binding site [ion binding]; other site 645657007965 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657007966 nucleotide binding region [chemical binding]; other site 645657007967 ATP-binding site [chemical binding]; other site 645657007968 integrase/recombinase; Provisional; Region: PRK15417 645657007969 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645657007970 active site 645657007971 DNA binding site [nucleotide binding] 645657007972 Int/Topo IB signature motif; other site 645657007973 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 645657007974 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 645657007975 active site 645657007976 metal binding site [ion binding]; metal-binding site 645657007977 homotetramer interface [polypeptide binding]; other site 645657007978 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 645657007979 active site 645657007980 dimerization interface [polypeptide binding]; other site 645657007981 ribonuclease PH; Reviewed; Region: rph; PRK00173 645657007982 Ribonuclease PH; Region: RNase_PH_bact; cd11362 645657007983 hexamer interface [polypeptide binding]; other site 645657007984 active site 645657007985 Spore germination protein [General function prediction only]; Region: COG5401 645657007986 Sporulation and spore germination; Region: Germane; pfam10646 645657007987 Sporulation and spore germination; Region: Germane; pfam10646 645657007988 glutamate racemase; Region: glut_race; TIGR00067 645657007989 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657007990 MarR family; Region: MarR; pfam01047 645657007991 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645657007992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645657007993 DNA binding residues [nucleotide binding] 645657007994 dimerization interface [polypeptide binding]; other site 645657007995 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 645657007996 active site 645657007997 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 645657007998 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 645657007999 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 645657008000 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 645657008001 L-aspartate oxidase; Provisional; Region: PRK06175 645657008002 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 645657008003 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 645657008004 putative Iron-sulfur protein interface [polypeptide binding]; other site 645657008005 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 645657008006 proximal heme binding site [chemical binding]; other site 645657008007 distal heme binding site [chemical binding]; other site 645657008008 putative dimer interface [polypeptide binding]; other site 645657008009 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 645657008010 aspartate kinase; Reviewed; Region: PRK06635 645657008011 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 645657008012 putative nucleotide binding site [chemical binding]; other site 645657008013 putative catalytic residues [active] 645657008014 putative Mg ion binding site [ion binding]; other site 645657008015 putative aspartate binding site [chemical binding]; other site 645657008016 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 645657008017 putative allosteric regulatory site; other site 645657008018 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 645657008019 putative allosteric regulatory residue; other site 645657008020 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 645657008021 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 645657008022 GIY-YIG motif/motif A; other site 645657008023 active site 645657008024 catalytic site [active] 645657008025 putative DNA binding site [nucleotide binding]; other site 645657008026 metal binding site [ion binding]; metal-binding site 645657008027 UvrB/uvrC motif; Region: UVR; pfam02151 645657008028 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 645657008029 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 645657008030 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 645657008031 catalytic residues [active] 645657008032 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 645657008033 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 645657008034 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 645657008035 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 645657008036 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 645657008037 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 645657008038 Ligand binding site [chemical binding]; other site 645657008039 Electron transfer flavoprotein domain; Region: ETF; pfam01012 645657008040 enoyl-CoA hydratase; Provisional; Region: PRK07658 645657008041 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 645657008042 substrate binding site [chemical binding]; other site 645657008043 oxyanion hole (OAH) forming residues; other site 645657008044 trimer interface [polypeptide binding]; other site 645657008045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657008046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657008047 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 645657008048 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 645657008049 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 645657008050 acyl-activating enzyme (AAE) consensus motif; other site 645657008051 putative AMP binding site [chemical binding]; other site 645657008052 putative active site [active] 645657008053 putative CoA binding site [chemical binding]; other site 645657008054 Predicted membrane protein [Function unknown]; Region: COG3766 645657008055 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 645657008056 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 645657008057 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 645657008058 MutS domain III; Region: MutS_III; pfam05192 645657008059 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 645657008060 Walker A/P-loop; other site 645657008061 ATP binding site [chemical binding]; other site 645657008062 Q-loop/lid; other site 645657008063 ABC transporter signature motif; other site 645657008064 Walker B; other site 645657008065 D-loop; other site 645657008066 H-loop/switch region; other site 645657008067 Smr domain; Region: Smr; pfam01713 645657008068 hypothetical protein; Provisional; Region: PRK08609 645657008069 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 645657008070 active site 645657008071 primer binding site [nucleotide binding]; other site 645657008072 NTP binding site [chemical binding]; other site 645657008073 metal binding triad [ion binding]; metal-binding site 645657008074 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 645657008075 active site 645657008076 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 645657008077 Colicin V production protein; Region: Colicin_V; pfam02674 645657008078 cell division protein ZapA; Provisional; Region: PRK14126 645657008079 ribonuclease HIII; Provisional; Region: PRK00996 645657008080 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 645657008081 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 645657008082 RNA/DNA hybrid binding site [nucleotide binding]; other site 645657008083 active site 645657008084 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 645657008085 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 645657008086 putative tRNA-binding site [nucleotide binding]; other site 645657008087 B3/4 domain; Region: B3_4; pfam03483 645657008088 tRNA synthetase B5 domain; Region: B5; smart00874 645657008089 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 645657008090 dimer interface [polypeptide binding]; other site 645657008091 motif 1; other site 645657008092 motif 3; other site 645657008093 motif 2; other site 645657008094 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 645657008095 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 645657008096 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 645657008097 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 645657008098 dimer interface [polypeptide binding]; other site 645657008099 motif 1; other site 645657008100 active site 645657008101 motif 2; other site 645657008102 motif 3; other site 645657008103 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 645657008104 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 645657008105 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 645657008106 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 645657008107 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 645657008108 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 645657008109 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 645657008110 FAD binding domain; Region: FAD_binding_4; pfam01565 645657008111 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 645657008112 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 645657008113 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 645657008114 Cysteine-rich domain; Region: CCG; pfam02754 645657008115 Cysteine-rich domain; Region: CCG; pfam02754 645657008116 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 645657008117 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657008118 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 645657008119 Carbon starvation protein CstA; Region: CstA; pfam02554 645657008120 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 645657008121 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 645657008122 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 645657008123 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 645657008124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657008125 dimer interface [polypeptide binding]; other site 645657008126 conserved gate region; other site 645657008127 putative PBP binding loops; other site 645657008128 ABC-ATPase subunit interface; other site 645657008129 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 645657008130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657008131 dimer interface [polypeptide binding]; other site 645657008132 conserved gate region; other site 645657008133 putative PBP binding loops; other site 645657008134 ABC-ATPase subunit interface; other site 645657008135 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 645657008136 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 645657008137 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 645657008138 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 645657008139 active site 645657008140 metal binding site [ion binding]; metal-binding site 645657008141 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 645657008142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657008143 active site 645657008144 motif I; other site 645657008145 motif II; other site 645657008146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657008147 motif II; other site 645657008148 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 645657008149 L-ribulose-5-phosphate 4-epimerase; Region: araD; TIGR00760 645657008150 intersubunit interface [polypeptide binding]; other site 645657008151 active site 645657008152 Zn2+ binding site [ion binding]; other site 645657008153 L-ribulokinase; Region: L-ribulokinase; TIGR01234 645657008154 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 645657008155 N- and C-terminal domain interface [polypeptide binding]; other site 645657008156 active site 645657008157 MgATP binding site [chemical binding]; other site 645657008158 catalytic site [active] 645657008159 metal binding site [ion binding]; metal-binding site 645657008160 carbohydrate binding site [chemical binding]; other site 645657008161 homodimer interface [polypeptide binding]; other site 645657008162 L-arabinose isomerase; Provisional; Region: PRK02929 645657008163 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 645657008164 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 645657008165 trimer interface [polypeptide binding]; other site 645657008166 putative substrate binding site [chemical binding]; other site 645657008167 putative metal binding site [ion binding]; other site 645657008168 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 645657008169 active site 645657008170 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 645657008171 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 645657008172 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 645657008173 oligomer interface [polypeptide binding]; other site 645657008174 active site 645657008175 metal binding site [ion binding]; metal-binding site 645657008176 Predicted membrane protein [Function unknown]; Region: COG3326 645657008177 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 645657008178 23S rRNA binding site [nucleotide binding]; other site 645657008179 L21 binding site [polypeptide binding]; other site 645657008180 L13 binding site [polypeptide binding]; other site 645657008181 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 645657008182 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 645657008183 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 645657008184 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 645657008185 antiholin-like protein LrgB; Provisional; Region: PRK04288 645657008186 LrgA family; Region: LrgA; cl00608 645657008187 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 645657008188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657008189 active site 645657008190 phosphorylation site [posttranslational modification] 645657008191 intermolecular recognition site; other site 645657008192 dimerization interface [polypeptide binding]; other site 645657008193 LytTr DNA-binding domain; Region: LytTR; pfam04397 645657008194 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 645657008195 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 645657008196 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 645657008197 Histidine kinase; Region: His_kinase; pfam06580 645657008198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657008199 ATP binding site [chemical binding]; other site 645657008200 Mg2+ binding site [ion binding]; other site 645657008201 G-X-G motif; other site 645657008202 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 645657008203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657008204 motif II; other site 645657008205 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 645657008206 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 645657008207 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 645657008208 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 645657008209 active site 645657008210 dimer interface [polypeptide binding]; other site 645657008211 motif 1; other site 645657008212 motif 2; other site 645657008213 motif 3; other site 645657008214 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 645657008215 anticodon binding site; other site 645657008216 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 645657008217 Uncharacterized conserved protein [Function unknown]; Region: COG0398 645657008218 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 645657008219 primosomal protein DnaI; Reviewed; Region: PRK08939 645657008220 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 645657008221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657008222 Walker A motif; other site 645657008223 ATP binding site [chemical binding]; other site 645657008224 Walker B motif; other site 645657008225 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 645657008226 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 645657008227 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 645657008228 ATP cone domain; Region: ATP-cone; pfam03477 645657008229 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 645657008230 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 645657008231 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 645657008232 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 645657008233 Predicted transcriptional regulators [Transcription]; Region: COG1733 645657008234 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 645657008235 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 645657008236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657008237 putative substrate translocation pore; other site 645657008238 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645657008239 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645657008240 active site 645657008241 catalytic tetrad [active] 645657008242 dephospho-CoA kinase; Region: TIGR00152 645657008243 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 645657008244 CoA-binding site [chemical binding]; other site 645657008245 ATP-binding [chemical binding]; other site 645657008246 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 645657008247 Domain of unknown function DUF; Region: DUF204; pfam02659 645657008248 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 645657008249 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 645657008250 DNA binding site [nucleotide binding] 645657008251 catalytic residue [active] 645657008252 H2TH interface [polypeptide binding]; other site 645657008253 putative catalytic residues [active] 645657008254 turnover-facilitating residue; other site 645657008255 intercalation triad [nucleotide binding]; other site 645657008256 8OG recognition residue [nucleotide binding]; other site 645657008257 putative reading head residues; other site 645657008258 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 645657008259 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 645657008260 DNA polymerase I; Provisional; Region: PRK05755 645657008261 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 645657008262 active site 645657008263 metal binding site 1 [ion binding]; metal-binding site 645657008264 putative 5' ssDNA interaction site; other site 645657008265 metal binding site 3; metal-binding site 645657008266 metal binding site 2 [ion binding]; metal-binding site 645657008267 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 645657008268 putative DNA binding site [nucleotide binding]; other site 645657008269 putative metal binding site [ion binding]; other site 645657008270 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 645657008271 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 645657008272 active site 645657008273 DNA binding site [nucleotide binding] 645657008274 catalytic site [active] 645657008275 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 645657008276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657008277 putative active site [active] 645657008278 heme pocket [chemical binding]; other site 645657008279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657008280 dimer interface [polypeptide binding]; other site 645657008281 phosphorylation site [posttranslational modification] 645657008282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657008283 ATP binding site [chemical binding]; other site 645657008284 Mg2+ binding site [ion binding]; other site 645657008285 G-X-G motif; other site 645657008286 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645657008287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657008288 active site 645657008289 phosphorylation site [posttranslational modification] 645657008290 intermolecular recognition site; other site 645657008291 dimerization interface [polypeptide binding]; other site 645657008292 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645657008293 DNA binding site [nucleotide binding] 645657008294 malate dehydrogenase; Reviewed; Region: PRK06223 645657008295 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 645657008296 NAD(P) binding site [chemical binding]; other site 645657008297 dimer interface [polypeptide binding]; other site 645657008298 tetramer (dimer of dimers) interface [polypeptide binding]; other site 645657008299 substrate binding site [chemical binding]; other site 645657008300 isocitrate dehydrogenase; Reviewed; Region: PRK07006 645657008301 isocitrate dehydrogenase; Validated; Region: PRK07362 645657008302 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 645657008303 dimer interface [polypeptide binding]; other site 645657008304 Citrate synthase; Region: Citrate_synt; pfam00285 645657008305 active site 645657008306 citrylCoA binding site [chemical binding]; other site 645657008307 oxalacetate/citrate binding site [chemical binding]; other site 645657008308 coenzyme A binding site [chemical binding]; other site 645657008309 catalytic triad [active] 645657008310 Predicted membrane protein [Function unknown]; Region: COG2707 645657008311 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 645657008312 Domain of unknown function DUF20; Region: UPF0118; pfam01594 645657008313 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 645657008314 pyruvate kinase; Provisional; Region: PRK06354 645657008315 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 645657008316 domain interfaces; other site 645657008317 active site 645657008318 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 645657008319 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 645657008320 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 645657008321 active site 645657008322 ADP/pyrophosphate binding site [chemical binding]; other site 645657008323 dimerization interface [polypeptide binding]; other site 645657008324 allosteric effector site; other site 645657008325 fructose-1,6-bisphosphate binding site; other site 645657008326 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 645657008327 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 645657008328 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 645657008329 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 645657008330 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 645657008331 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 645657008332 Malic enzyme, N-terminal domain; Region: malic; pfam00390 645657008333 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 645657008334 putative NAD(P) binding site [chemical binding]; other site 645657008335 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 645657008336 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 645657008337 active site 645657008338 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 645657008339 generic binding surface I; other site 645657008340 generic binding surface II; other site 645657008341 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 645657008342 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 645657008343 DHH family; Region: DHH; pfam01368 645657008344 DHHA1 domain; Region: DHHA1; pfam02272 645657008345 YtpI-like protein; Region: YtpI; pfam14007 645657008346 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 645657008347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657008348 DNA-binding site [nucleotide binding]; DNA binding site 645657008349 DRTGG domain; Region: DRTGG; pfam07085 645657008350 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 645657008351 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 645657008352 active site 2 [active] 645657008353 active site 1 [active] 645657008354 Transposase domain (DUF772); Region: DUF772; pfam05598 645657008355 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 645657008356 metal-dependent hydrolase; Provisional; Region: PRK00685 645657008357 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 645657008358 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 645657008359 classical (c) SDRs; Region: SDR_c; cd05233 645657008360 NAD(P) binding site [chemical binding]; other site 645657008361 active site 645657008362 argininosuccinate lyase; Provisional; Region: PRK00855 645657008363 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 645657008364 active sites [active] 645657008365 tetramer interface [polypeptide binding]; other site 645657008366 argininosuccinate synthase; Provisional; Region: PRK13820 645657008367 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 645657008368 ANP binding site [chemical binding]; other site 645657008369 Substrate Binding Site II [chemical binding]; other site 645657008370 Substrate Binding Site I [chemical binding]; other site 645657008371 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 645657008372 MPT binding site; other site 645657008373 trimer interface [polypeptide binding]; other site 645657008374 propionate/acetate kinase; Provisional; Region: PRK12379 645657008375 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645657008376 nucleotide binding site [chemical binding]; other site 645657008377 butyrate kinase; Provisional; Region: PRK03011 645657008378 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 645657008379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657008380 S-adenosylmethionine binding site [chemical binding]; other site 645657008381 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 645657008382 dimer interface [polypeptide binding]; other site 645657008383 catalytic triad [active] 645657008384 peroxidatic and resolving cysteines [active] 645657008385 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 645657008386 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 645657008387 Predicted membrane protein/domain [Function unknown]; Region: COG1714 645657008388 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 645657008389 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 645657008390 tandem repeat interface [polypeptide binding]; other site 645657008391 oligomer interface [polypeptide binding]; other site 645657008392 active site residues [active] 645657008393 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 645657008394 ATP-NAD kinase; Region: NAD_kinase; pfam01513 645657008395 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 645657008396 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 645657008397 active site 645657008398 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 645657008399 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 645657008400 active site 645657008401 acyl-activating enzyme (AAE) consensus motif; other site 645657008402 putative CoA binding site [chemical binding]; other site 645657008403 AMP binding site [chemical binding]; other site 645657008404 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 645657008405 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 645657008406 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 645657008407 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 645657008408 Ligand Binding Site [chemical binding]; other site 645657008409 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 645657008410 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 645657008411 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645657008412 catalytic residue [active] 645657008413 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 645657008414 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 645657008415 histidinol-phosphatase; Reviewed; Region: PRK08123 645657008416 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 645657008417 active site 645657008418 dimer interface [polypeptide binding]; other site 645657008419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657008420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657008421 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 645657008422 GAF domain; Region: GAF_2; pfam13185 645657008423 GAF domain; Region: GAF_3; pfam13492 645657008424 GAF domain; Region: GAF_2; pfam13185 645657008425 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 645657008426 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645657008427 metal binding site [ion binding]; metal-binding site 645657008428 active site 645657008429 I-site; other site 645657008430 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 645657008431 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 645657008432 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645657008433 RNA binding surface [nucleotide binding]; other site 645657008434 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 645657008435 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 645657008436 active site 645657008437 HIGH motif; other site 645657008438 dimer interface [polypeptide binding]; other site 645657008439 KMSKS motif; other site 645657008440 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645657008441 RNA binding surface [nucleotide binding]; other site 645657008442 acetyl-CoA synthetase; Provisional; Region: PRK04319 645657008443 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 645657008444 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 645657008445 active site 645657008446 acyl-activating enzyme (AAE) consensus motif; other site 645657008447 putative CoA binding site [chemical binding]; other site 645657008448 AMP binding site [chemical binding]; other site 645657008449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657008450 Coenzyme A binding pocket [chemical binding]; other site 645657008451 FOG: CBS domain [General function prediction only]; Region: COG0517 645657008452 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 645657008453 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 645657008454 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 645657008455 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 645657008456 active site 645657008457 Zn binding site [ion binding]; other site 645657008458 flagellar motor protein MotS; Reviewed; Region: PRK06925 645657008459 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 645657008460 ligand binding site [chemical binding]; other site 645657008461 flagellar motor protein MotP; Reviewed; Region: PRK06926 645657008462 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 645657008463 catabolite control protein A; Region: ccpA; TIGR01481 645657008464 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645657008465 DNA binding site [nucleotide binding] 645657008466 domain linker motif; other site 645657008467 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 645657008468 dimerization interface [polypeptide binding]; other site 645657008469 effector binding site; other site 645657008470 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 645657008471 chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801 645657008472 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 645657008473 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 645657008474 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 645657008475 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 645657008476 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 645657008477 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 645657008478 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645657008479 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645657008480 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 645657008481 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645657008482 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 645657008483 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 645657008484 putative tRNA-binding site [nucleotide binding]; other site 645657008485 hypothetical protein; Provisional; Region: PRK13668 645657008486 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 645657008487 catalytic residues [active] 645657008488 YtoQ family protein; Region: YtoQ_fam; TIGR03646 645657008489 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 645657008490 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 645657008491 oligomer interface [polypeptide binding]; other site 645657008492 active site 645657008493 metal binding site [ion binding]; metal-binding site 645657008494 Predicted small secreted protein [Function unknown]; Region: COG5584 645657008495 malate dehydrogenase; Provisional; Region: PRK13529 645657008496 Malic enzyme, N-terminal domain; Region: malic; pfam00390 645657008497 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 645657008498 NAD(P) binding site [chemical binding]; other site 645657008499 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645657008500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657008501 S-adenosylmethionine binding site [chemical binding]; other site 645657008502 YtzH-like protein; Region: YtzH; pfam14165 645657008503 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 645657008504 active site 645657008505 ATP binding site [chemical binding]; other site 645657008506 Phosphotransferase enzyme family; Region: APH; pfam01636 645657008507 substrate binding site [chemical binding]; other site 645657008508 pullulanase, type I; Region: pulA_typeI; TIGR02104 645657008509 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 645657008510 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 645657008511 Ca binding site [ion binding]; other site 645657008512 active site 645657008513 catalytic site [active] 645657008514 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 645657008515 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 645657008516 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 645657008517 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 645657008518 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 645657008519 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 645657008520 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 645657008521 dimer interface [polypeptide binding]; other site 645657008522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657008523 catalytic residue [active] 645657008524 dipeptidase PepV; Reviewed; Region: PRK07318 645657008525 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 645657008526 active site 645657008527 metal binding site [ion binding]; metal-binding site 645657008528 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 645657008529 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 645657008530 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 645657008531 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645657008532 Walker A/P-loop; other site 645657008533 ATP binding site [chemical binding]; other site 645657008534 Q-loop/lid; other site 645657008535 ABC transporter signature motif; other site 645657008536 Walker B; other site 645657008537 D-loop; other site 645657008538 H-loop/switch region; other site 645657008539 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 645657008540 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 645657008541 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645657008542 RNA binding surface [nucleotide binding]; other site 645657008543 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 645657008544 active site 645657008545 uracil binding [chemical binding]; other site 645657008546 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 645657008547 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 645657008548 Predicted flavoproteins [General function prediction only]; Region: COG2081 645657008549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645657008550 BCCT family transporter; Region: BCCT; pfam02028 645657008551 BCCT family transporter; Region: BCCT; pfam02028 645657008552 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 645657008553 Predicted integral membrane protein [Function unknown]; Region: COG5578 645657008554 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 645657008555 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 645657008556 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 645657008557 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 645657008558 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 645657008559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657008560 dimer interface [polypeptide binding]; other site 645657008561 conserved gate region; other site 645657008562 ABC-ATPase subunit interface; other site 645657008563 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 645657008564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657008565 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645657008566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645657008567 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 645657008568 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 645657008569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657008570 dimer interface [polypeptide binding]; other site 645657008571 conserved gate region; other site 645657008572 putative PBP binding loops; other site 645657008573 ABC-ATPase subunit interface; other site 645657008574 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 645657008575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645657008576 NAD(P) binding site [chemical binding]; other site 645657008577 active site 645657008578 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 645657008579 Cytochrome P450; Region: p450; cl12078 645657008580 biotin synthase; Validated; Region: PRK06256 645657008581 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645657008582 FeS/SAM binding site; other site 645657008583 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 645657008584 AAA domain; Region: AAA_26; pfam13500 645657008585 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 645657008586 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 645657008587 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 645657008588 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 645657008589 substrate-cofactor binding pocket; other site 645657008590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657008591 catalytic residue [active] 645657008592 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 645657008593 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645657008594 inhibitor-cofactor binding pocket; inhibition site 645657008595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657008596 catalytic residue [active] 645657008597 6-carboxyhexanoate--CoA ligase; Region: bioW; TIGR01204 645657008598 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 645657008599 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 645657008600 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645657008601 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645657008602 DNA binding site [nucleotide binding] 645657008603 domain linker motif; other site 645657008604 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 645657008605 putative ligand binding site [chemical binding]; other site 645657008606 putative dimerization interface [polypeptide binding]; other site 645657008607 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 645657008608 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 645657008609 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 645657008610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657008611 dimer interface [polypeptide binding]; other site 645657008612 conserved gate region; other site 645657008613 putative PBP binding loops; other site 645657008614 ABC-ATPase subunit interface; other site 645657008615 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 645657008616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657008617 dimer interface [polypeptide binding]; other site 645657008618 conserved gate region; other site 645657008619 putative PBP binding loops; other site 645657008620 ABC-ATPase subunit interface; other site 645657008621 alpha-galactosidase; Provisional; Region: PRK15076 645657008622 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 645657008623 NAD binding site [chemical binding]; other site 645657008624 sugar binding site [chemical binding]; other site 645657008625 divalent metal binding site [ion binding]; other site 645657008626 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 645657008627 dimer interface [polypeptide binding]; other site 645657008628 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 645657008629 active site residue [active] 645657008630 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 645657008631 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 645657008632 HIGH motif; other site 645657008633 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 645657008634 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645657008635 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 645657008636 active site 645657008637 KMSKS motif; other site 645657008638 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 645657008639 tRNA binding surface [nucleotide binding]; other site 645657008640 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 645657008641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657008642 PAS domain; Region: PAS_9; pfam13426 645657008643 putative active site [active] 645657008644 heme pocket [chemical binding]; other site 645657008645 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 645657008646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657008647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657008648 putative substrate translocation pore; other site 645657008649 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 645657008650 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 645657008651 FtsX-like permease family; Region: FtsX; pfam02687 645657008652 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645657008653 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645657008654 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645657008655 Walker A/P-loop; other site 645657008656 ATP binding site [chemical binding]; other site 645657008657 Q-loop/lid; other site 645657008658 ABC transporter signature motif; other site 645657008659 Walker B; other site 645657008660 D-loop; other site 645657008661 H-loop/switch region; other site 645657008662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645657008663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657008664 ATP binding site [chemical binding]; other site 645657008665 Mg2+ binding site [ion binding]; other site 645657008666 G-X-G motif; other site 645657008667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645657008668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657008669 active site 645657008670 phosphorylation site [posttranslational modification] 645657008671 intermolecular recognition site; other site 645657008672 dimerization interface [polypeptide binding]; other site 645657008673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645657008674 DNA binding site [nucleotide binding] 645657008675 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645657008676 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645657008677 FtsX-like permease family; Region: FtsX; pfam02687 645657008678 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645657008679 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645657008680 Walker A/P-loop; other site 645657008681 ATP binding site [chemical binding]; other site 645657008682 Q-loop/lid; other site 645657008683 ABC transporter signature motif; other site 645657008684 Walker B; other site 645657008685 D-loop; other site 645657008686 H-loop/switch region; other site 645657008687 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 645657008688 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 645657008689 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645657008690 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645657008691 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645657008692 Walker A/P-loop; other site 645657008693 ATP binding site [chemical binding]; other site 645657008694 Q-loop/lid; other site 645657008695 ABC transporter signature motif; other site 645657008696 Walker B; other site 645657008697 D-loop; other site 645657008698 H-loop/switch region; other site 645657008699 Predicted transcriptional regulators [Transcription]; Region: COG1725 645657008700 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657008701 DNA-binding site [nucleotide binding]; DNA binding site 645657008702 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 645657008703 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 645657008704 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 645657008705 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 645657008706 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 645657008707 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 645657008708 PGAP1-like protein; Region: PGAP1; pfam07819 645657008709 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 645657008710 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 645657008711 trimer interface [polypeptide binding]; other site 645657008712 putative metal binding site [ion binding]; other site 645657008713 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 645657008714 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 645657008715 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 645657008716 active site 645657008717 dimer interface [polypeptide binding]; other site 645657008718 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 645657008719 Ligand Binding Site [chemical binding]; other site 645657008720 Molecular Tunnel; other site 645657008721 S-adenosylmethionine synthetase; Validated; Region: PRK05250 645657008722 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 645657008723 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 645657008724 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 645657008725 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 645657008726 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 645657008727 active site 645657008728 substrate-binding site [chemical binding]; other site 645657008729 metal-binding site [ion binding] 645657008730 ATP binding site [chemical binding]; other site 645657008731 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 645657008732 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 645657008733 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 645657008734 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 645657008735 NMT1-like family; Region: NMT1_2; pfam13379 645657008736 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 645657008737 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 645657008738 Walker A/P-loop; other site 645657008739 ATP binding site [chemical binding]; other site 645657008740 Q-loop/lid; other site 645657008741 ABC transporter signature motif; other site 645657008742 Walker B; other site 645657008743 D-loop; other site 645657008744 H-loop/switch region; other site 645657008745 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 645657008746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657008747 dimer interface [polypeptide binding]; other site 645657008748 conserved gate region; other site 645657008749 putative PBP binding loops; other site 645657008750 ABC-ATPase subunit interface; other site 645657008751 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 645657008752 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 645657008753 nudix motif; other site 645657008754 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 645657008755 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 645657008756 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 645657008757 dimerization interface [polypeptide binding]; other site 645657008758 DPS ferroxidase diiron center [ion binding]; other site 645657008759 ion pore; other site 645657008760 YtkA-like; Region: YtkA; pfam13115 645657008761 S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664 645657008762 Haemolytic domain; Region: Haemolytic; pfam01809 645657008763 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 645657008764 active site clefts [active] 645657008765 zinc binding site [ion binding]; other site 645657008766 dimer interface [polypeptide binding]; other site 645657008767 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 645657008768 Cytochrome bd-type quinol oxidase, subunit 1 [Energy production and conversion]; Region: CydA; COG1271 645657008769 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 645657008770 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 645657008771 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 645657008772 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645657008773 ABC-ATPase subunit interface; other site 645657008774 dimer interface [polypeptide binding]; other site 645657008775 putative PBP binding regions; other site 645657008776 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 645657008777 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645657008778 ABC-ATPase subunit interface; other site 645657008779 dimer interface [polypeptide binding]; other site 645657008780 putative PBP binding regions; other site 645657008781 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 645657008782 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 645657008783 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 645657008784 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 645657008785 metal binding site [ion binding]; metal-binding site 645657008786 intersubunit interface [polypeptide binding]; other site 645657008787 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 645657008788 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 645657008789 active site 645657008790 octamer interface [polypeptide binding]; other site 645657008791 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 645657008792 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 645657008793 acyl-activating enzyme (AAE) consensus motif; other site 645657008794 putative AMP binding site [chemical binding]; other site 645657008795 putative active site [active] 645657008796 putative CoA binding site [chemical binding]; other site 645657008797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 645657008798 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 645657008799 substrate binding site [chemical binding]; other site 645657008800 oxyanion hole (OAH) forming residues; other site 645657008801 trimer interface [polypeptide binding]; other site 645657008802 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 645657008803 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 645657008804 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 645657008805 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 645657008806 dimer interface [polypeptide binding]; other site 645657008807 tetramer interface [polypeptide binding]; other site 645657008808 PYR/PP interface [polypeptide binding]; other site 645657008809 TPP binding site [chemical binding]; other site 645657008810 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 645657008811 TPP-binding site; other site 645657008812 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 645657008813 chorismate binding enzyme; Region: Chorismate_bind; cl10555 645657008814 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 645657008815 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 645657008816 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 645657008817 active site 645657008818 tetramer interface; other site 645657008819 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 645657008820 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 645657008821 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 645657008822 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 645657008823 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 645657008824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645657008825 NAD(P) binding site [chemical binding]; other site 645657008826 active site 645657008827 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645657008828 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 645657008829 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 645657008830 spore coat protein YutH; Region: spore_yutH; TIGR02905 645657008831 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645657008832 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 645657008833 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 645657008834 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 645657008835 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 645657008836 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 645657008837 homodimer interface [polypeptide binding]; other site 645657008838 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 645657008839 active site pocket [active] 645657008840 glycogen synthase; Provisional; Region: glgA; PRK00654 645657008841 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 645657008842 ADP-binding pocket [chemical binding]; other site 645657008843 homodimer interface [polypeptide binding]; other site 645657008844 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 645657008845 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 645657008846 ligand binding site; other site 645657008847 oligomer interface; other site 645657008848 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 645657008849 dimer interface [polypeptide binding]; other site 645657008850 N-terminal domain interface [polypeptide binding]; other site 645657008851 sulfate 1 binding site; other site 645657008852 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 645657008853 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 645657008854 ligand binding site; other site 645657008855 oligomer interface; other site 645657008856 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 645657008857 dimer interface [polypeptide binding]; other site 645657008858 N-terminal domain interface [polypeptide binding]; other site 645657008859 sulfate 1 binding site; other site 645657008860 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 645657008861 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 645657008862 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 645657008863 active site 645657008864 catalytic site [active] 645657008865 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 645657008866 Predicted membrane protein [Function unknown]; Region: COG3859 645657008867 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 645657008868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657008869 Coenzyme A binding pocket [chemical binding]; other site 645657008870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 645657008871 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 645657008872 DinB superfamily; Region: DinB_2; pfam12867 645657008873 metal-dependent hydrolase; Provisional; Region: PRK13291 645657008874 MOSC domain; Region: MOSC; pfam03473 645657008875 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 645657008876 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 645657008877 active site 645657008878 NAD binding site [chemical binding]; other site 645657008879 metal binding site [ion binding]; metal-binding site 645657008880 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 645657008881 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 645657008882 tetramerization interface [polypeptide binding]; other site 645657008883 NAD(P) binding site [chemical binding]; other site 645657008884 catalytic residues [active] 645657008885 Predicted transcriptional regulators [Transcription]; Region: COG1510 645657008886 MarR family; Region: MarR_2; pfam12802 645657008887 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 645657008888 TrkA-N domain; Region: TrkA_N; pfam02254 645657008889 TrkA-C domain; Region: TrkA_C; pfam02080 645657008890 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 645657008891 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 645657008892 Predicted membrane protein [Function unknown]; Region: COG4682 645657008893 yiaA/B two helix domain; Region: YiaAB; pfam05360 645657008894 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 645657008895 SH3-like domain; Region: SH3_8; pfam13457 645657008896 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657008897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657008898 putative substrate translocation pore; other site 645657008899 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 645657008900 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 645657008901 Domain of unknown function DUF20; Region: UPF0118; pfam01594 645657008902 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 645657008903 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 645657008904 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 645657008905 L-rhamnose isomerase (RhaA); Region: RhaA; pfam06134 645657008906 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 645657008907 Domain of unknown function (DUF718); Region: DUF718; cl01281 645657008908 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 645657008909 N- and C-terminal domain interface [polypeptide binding]; other site 645657008910 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 645657008911 active site 645657008912 putative catalytic site [active] 645657008913 metal binding site [ion binding]; metal-binding site 645657008914 ATP binding site [chemical binding]; other site 645657008915 carbohydrate binding site [chemical binding]; other site 645657008916 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 645657008917 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 645657008918 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 645657008919 short chain dehydrogenase; Validated; Region: PRK08324 645657008920 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 645657008921 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 645657008922 putative NAD(P) binding site [chemical binding]; other site 645657008923 active site 645657008924 Cache domain; Region: Cache_1; pfam02743 645657008925 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645657008926 dimerization interface [polypeptide binding]; other site 645657008927 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 645657008928 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 645657008929 dimer interface [polypeptide binding]; other site 645657008930 putative CheW interface [polypeptide binding]; other site 645657008931 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 645657008932 Cache domain; Region: Cache_1; pfam02743 645657008933 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 645657008934 Cache domain; Region: Cache_1; pfam02743 645657008935 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645657008936 dimerization interface [polypeptide binding]; other site 645657008937 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 645657008938 dimer interface [polypeptide binding]; other site 645657008939 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 645657008940 putative CheW interface [polypeptide binding]; other site 645657008941 Cache domain; Region: Cache_1; pfam02743 645657008942 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 645657008943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645657008944 dimerization interface [polypeptide binding]; other site 645657008945 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 645657008946 dimer interface [polypeptide binding]; other site 645657008947 putative CheW interface [polypeptide binding]; other site 645657008948 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 645657008949 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 645657008950 Cache domain; Region: Cache_1; pfam02743 645657008951 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645657008952 dimerization interface [polypeptide binding]; other site 645657008953 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 645657008954 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 645657008955 dimer interface [polypeptide binding]; other site 645657008956 putative CheW interface [polypeptide binding]; other site 645657008957 transglutaminase; Provisional; Region: tgl; PRK03187 645657008958 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 645657008959 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 645657008960 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 645657008961 Ca binding site [ion binding]; other site 645657008962 active site 645657008963 catalytic site [active] 645657008964 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 645657008965 Domain of unknown function DUF21; Region: DUF21; pfam01595 645657008966 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 645657008967 Transporter associated domain; Region: CorC_HlyC; smart01091 645657008968 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 645657008969 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 645657008970 Ion channel; Region: Ion_trans_2; pfam07885 645657008971 TrkA-N domain; Region: TrkA_N; pfam02254 645657008972 YugN-like family; Region: YugN; pfam08868 645657008973 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 645657008974 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 645657008975 active site 645657008976 dimer interface [polypeptide binding]; other site 645657008977 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 645657008978 dimer interface [polypeptide binding]; other site 645657008979 active site 645657008980 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 645657008981 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 645657008982 dimer interface [polypeptide binding]; other site 645657008983 active site 645657008984 metal binding site [ion binding]; metal-binding site 645657008985 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 645657008986 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 645657008987 dimer interface [polypeptide binding]; other site 645657008988 active site 645657008989 metal binding site [ion binding]; metal-binding site 645657008990 Uncharacterized conserved protein [Function unknown]; Region: COG2155 645657008991 general stress protein 13; Validated; Region: PRK08059 645657008992 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 645657008993 RNA binding site [nucleotide binding]; other site 645657008994 hypothetical protein; Validated; Region: PRK07682 645657008995 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657008996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657008997 homodimer interface [polypeptide binding]; other site 645657008998 catalytic residue [active] 645657008999 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 645657009000 AsnC family; Region: AsnC_trans_reg; pfam01037 645657009001 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 645657009002 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 645657009003 nucleophilic elbow; other site 645657009004 catalytic triad; other site 645657009005 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 645657009006 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 645657009007 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657009008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657009009 homodimer interface [polypeptide binding]; other site 645657009010 catalytic residue [active] 645657009011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645657009012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657009013 dimer interface [polypeptide binding]; other site 645657009014 phosphorylation site [posttranslational modification] 645657009015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657009016 ATP binding site [chemical binding]; other site 645657009017 Mg2+ binding site [ion binding]; other site 645657009018 G-X-G motif; other site 645657009019 Kinase associated protein B; Region: KapB; pfam08810 645657009020 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 645657009021 active site 645657009022 catalytic site [active] 645657009023 substrate binding site [chemical binding]; other site 645657009024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657009025 putative substrate translocation pore; other site 645657009026 Transglycosylase; Region: Transgly; pfam00912 645657009027 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 645657009028 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 645657009029 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 645657009030 sensory histidine kinase DcuS; Provisional; Region: PRK11086 645657009031 PAS domain; Region: PAS; smart00091 645657009032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657009033 ATP binding site [chemical binding]; other site 645657009034 G-X-G motif; other site 645657009035 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 645657009036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657009037 active site 645657009038 phosphorylation site [posttranslational modification] 645657009039 intermolecular recognition site; other site 645657009040 dimerization interface [polypeptide binding]; other site 645657009041 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 645657009042 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 645657009043 ligand binding site [chemical binding]; other site 645657009044 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 645657009045 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 645657009046 Walker A/P-loop; other site 645657009047 ATP binding site [chemical binding]; other site 645657009048 Q-loop/lid; other site 645657009049 ABC transporter signature motif; other site 645657009050 Walker B; other site 645657009051 D-loop; other site 645657009052 H-loop/switch region; other site 645657009053 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 645657009054 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 645657009055 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 645657009056 TM-ABC transporter signature motif; other site 645657009057 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 645657009058 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 645657009059 TM-ABC transporter signature motif; other site 645657009060 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 645657009061 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 645657009062 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 645657009063 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 645657009064 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 645657009065 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 645657009066 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 645657009067 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 645657009068 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 645657009069 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 645657009070 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 645657009071 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 645657009072 CoenzymeA binding site [chemical binding]; other site 645657009073 subunit interaction site [polypeptide binding]; other site 645657009074 PHB binding site; other site 645657009075 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645657009076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657009077 active site 645657009078 phosphorylation site [posttranslational modification] 645657009079 intermolecular recognition site; other site 645657009080 dimerization interface [polypeptide binding]; other site 645657009081 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645657009082 DNA binding residues [nucleotide binding] 645657009083 dimerization interface [polypeptide binding]; other site 645657009084 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 645657009085 Histidine kinase; Region: HisKA_3; pfam07730 645657009086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657009087 ATP binding site [chemical binding]; other site 645657009088 Mg2+ binding site [ion binding]; other site 645657009089 G-X-G motif; other site 645657009090 Bacillus competence pheromone ComX; Region: ComX; pfam05952 645657009091 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 645657009092 substrate binding pocket [chemical binding]; other site 645657009093 substrate-Mg2+ binding site; other site 645657009094 aspartate-rich region 1; other site 645657009095 DegQ (SacQ) family; Region: DegQ; pfam08181 645657009096 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 645657009097 EAL domain; Region: EAL; pfam00563 645657009098 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 645657009099 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 645657009100 active site 645657009101 Isochorismatase family; Region: Isochorismatase; pfam00857 645657009102 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 645657009103 catalytic triad [active] 645657009104 conserved cis-peptide bond; other site 645657009105 Uncharacterized conserved protein [Function unknown]; Region: COG5506 645657009106 YueH-like protein; Region: YueH; pfam14166 645657009107 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 645657009108 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 645657009109 Domain of unknown function DUF20; Region: UPF0118; pfam01594 645657009110 Uncharacterized conserved small protein [Function unknown]; Region: COG5428 645657009111 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 645657009112 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645657009113 Zn2+ binding site [ion binding]; other site 645657009114 Mg2+ binding site [ion binding]; other site 645657009115 short chain dehydrogenase; Provisional; Region: PRK06924 645657009116 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 645657009117 NADP binding site [chemical binding]; other site 645657009118 homodimer interface [polypeptide binding]; other site 645657009119 active site 645657009120 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 645657009121 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 645657009122 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 645657009123 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 645657009124 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 645657009125 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 645657009126 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 645657009127 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 645657009128 Domain of unknown function DUF87; Region: DUF87; pfam01935 645657009129 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 645657009130 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 645657009131 Uncharacterized small protein [Function unknown]; Region: COG5417 645657009132 Ubiquitin homologues; Region: UBQ; smart00213 645657009133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 645657009134 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 645657009135 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 645657009136 alanine dehydrogenase; Region: alaDH; TIGR00518 645657009137 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 645657009138 hexamer interface [polypeptide binding]; other site 645657009139 ligand binding site [chemical binding]; other site 645657009140 putative active site [active] 645657009141 NAD(P) binding site [chemical binding]; other site 645657009142 Uncharacterized conserved protein [Function unknown]; Region: COG5634 645657009143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 645657009144 Condensation domain; Region: Condensation; pfam00668 645657009145 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 645657009146 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 645657009147 acyl-activating enzyme (AAE) consensus motif; other site 645657009148 AMP binding site [chemical binding]; other site 645657009149 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 645657009150 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 645657009151 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 645657009152 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 645657009153 acyl-activating enzyme (AAE) consensus motif; other site 645657009154 AMP binding site [chemical binding]; other site 645657009155 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 645657009156 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 645657009157 hydrophobic substrate binding pocket; other site 645657009158 Isochorismatase family; Region: Isochorismatase; pfam00857 645657009159 active site 645657009160 conserved cis-peptide bond; other site 645657009161 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 645657009162 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 645657009163 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 645657009164 acyl-activating enzyme (AAE) consensus motif; other site 645657009165 active site 645657009166 AMP binding site [chemical binding]; other site 645657009167 substrate binding site [chemical binding]; other site 645657009168 isochorismate synthase DhbC; Validated; Region: PRK06923 645657009169 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 645657009170 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 645657009171 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 645657009172 putative NAD(P) binding site [chemical binding]; other site 645657009173 active site 645657009174 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 645657009175 Putative esterase; Region: Esterase; pfam00756 645657009176 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 645657009177 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 645657009178 Moco binding site; other site 645657009179 metal coordination site [ion binding]; other site 645657009180 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 645657009181 Predicted permease [General function prediction only]; Region: COG2056 645657009182 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 645657009183 multifunctional aminopeptidase A; Provisional; Region: PRK00913 645657009184 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 645657009185 interface (dimer of trimers) [polypeptide binding]; other site 645657009186 Substrate-binding/catalytic site; other site 645657009187 Zn-binding sites [ion binding]; other site 645657009188 Divergent PAP2 family; Region: DUF212; pfam02681 645657009189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 645657009190 Putative membrane protein; Region: YuiB; pfam14068 645657009191 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 645657009192 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 645657009193 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645657009194 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 645657009195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645657009196 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645657009197 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 645657009198 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 645657009199 active site 645657009200 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 645657009201 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 645657009202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657009203 Coenzyme A binding pocket [chemical binding]; other site 645657009204 Short C-terminal domain; Region: SHOCT; pfam09851 645657009205 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 645657009206 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 645657009207 Phage-related protein [Function unknown]; Region: COG5412 645657009208 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 645657009209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657009210 non-specific DNA binding site [nucleotide binding]; other site 645657009211 salt bridge; other site 645657009212 sequence-specific DNA binding site [nucleotide binding]; other site 645657009213 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 645657009214 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645657009215 active site 645657009216 DNA binding site [nucleotide binding] 645657009217 Int/Topo IB signature motif; other site 645657009218 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 645657009219 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 645657009220 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 645657009221 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 645657009222 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 645657009223 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 645657009224 Nucleoside recognition; Region: Gate; pfam07670 645657009225 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 645657009226 hypothetical protein; Provisional; Region: PRK13669 645657009227 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 645657009228 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645657009229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 645657009230 NifU-like domain; Region: NifU; pfam01106 645657009231 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 645657009232 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 645657009233 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 645657009234 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 645657009235 homoserine kinase; Region: thrB; TIGR00191 645657009236 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 645657009237 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 645657009238 threonine synthase; Reviewed; Region: PRK06721 645657009239 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 645657009240 homodimer interface [polypeptide binding]; other site 645657009241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657009242 catalytic residue [active] 645657009243 homoserine dehydrogenase; Provisional; Region: PRK06349 645657009244 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 645657009245 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 645657009246 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 645657009247 spore coat protein YutH; Region: spore_yutH; TIGR02905 645657009248 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 645657009249 tetramer interfaces [polypeptide binding]; other site 645657009250 binuclear metal-binding site [ion binding]; other site 645657009251 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 645657009252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657009253 active site 645657009254 motif I; other site 645657009255 motif II; other site 645657009256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657009257 Uncharacterized conserved protein [Function unknown]; Region: COG2445 645657009258 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 645657009259 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 645657009260 lipoyl synthase; Provisional; Region: PRK05481 645657009261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645657009262 FeS/SAM binding site; other site 645657009263 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 645657009264 Peptidase family M23; Region: Peptidase_M23; pfam01551 645657009265 sporulation protein YunB; Region: spo_yunB; TIGR02832 645657009266 Uncharacterized conserved protein [Function unknown]; Region: COG3377 645657009267 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 645657009268 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 645657009269 active site 645657009270 metal binding site [ion binding]; metal-binding site 645657009271 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 645657009272 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 645657009273 Uncharacterized conserved protein [Function unknown]; Region: COG1801 645657009274 allantoinase; Provisional; Region: PRK06189 645657009275 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 645657009276 active site 645657009277 DRTGG domain; Region: DRTGG; pfam07085 645657009278 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 645657009279 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 645657009280 xanthine permease; Region: pbuX; TIGR03173 645657009281 xanthine permease; Region: pbuX; TIGR03173 645657009282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 645657009283 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 645657009284 Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the...; Region: Uricase; cd00445 645657009285 tetramer interface [polypeptide binding]; other site 645657009286 active site 645657009287 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 645657009288 active site 645657009289 homotetramer interface [polypeptide binding]; other site 645657009290 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 645657009291 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 645657009292 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 645657009293 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 645657009294 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 645657009295 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 645657009296 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 645657009297 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 645657009298 Ligand binding site; other site 645657009299 metal-binding site 645657009300 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 645657009301 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 645657009302 XdhC Rossmann domain; Region: XdhC_C; pfam13478 645657009303 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 645657009304 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645657009305 catalytic residue [active] 645657009306 allantoate amidohydrolase; Reviewed; Region: PRK09290 645657009307 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 645657009308 active site 645657009309 metal binding site [ion binding]; metal-binding site 645657009310 dimer interface [polypeptide binding]; other site 645657009311 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 645657009312 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 645657009313 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 645657009314 Walker A/P-loop; other site 645657009315 ATP binding site [chemical binding]; other site 645657009316 Q-loop/lid; other site 645657009317 ABC transporter signature motif; other site 645657009318 Walker B; other site 645657009319 D-loop; other site 645657009320 H-loop/switch region; other site 645657009321 TOBE domain; Region: TOBE_2; pfam08402 645657009322 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 645657009323 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657009324 DNA-binding site [nucleotide binding]; DNA binding site 645657009325 UTRA domain; Region: UTRA; pfam07702 645657009326 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 645657009327 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 645657009328 substrate binding site [chemical binding]; other site 645657009329 ATP binding site [chemical binding]; other site 645657009330 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 645657009331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657009332 dimer interface [polypeptide binding]; other site 645657009333 conserved gate region; other site 645657009334 putative PBP binding loops; other site 645657009335 ABC-ATPase subunit interface; other site 645657009336 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 645657009337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 645657009338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657009339 dimer interface [polypeptide binding]; other site 645657009340 conserved gate region; other site 645657009341 putative PBP binding loops; other site 645657009342 ABC-ATPase subunit interface; other site 645657009343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 645657009344 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 645657009345 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 645657009346 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 645657009347 putative active site [active] 645657009348 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 645657009349 dimer interface [polypeptide binding]; other site 645657009350 active site 645657009351 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 645657009352 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 645657009353 GIY-YIG motif/motif A; other site 645657009354 active site 645657009355 catalytic site [active] 645657009356 putative DNA binding site [nucleotide binding]; other site 645657009357 metal binding site [ion binding]; metal-binding site 645657009358 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 645657009359 hydroxyglutarate oxidase; Provisional; Region: PRK11728 645657009360 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657009361 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 645657009362 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 645657009363 FeS assembly protein SufB; Region: sufB; TIGR01980 645657009364 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 645657009365 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 645657009366 trimerization site [polypeptide binding]; other site 645657009367 active site 645657009368 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 645657009369 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 645657009370 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645657009371 catalytic residue [active] 645657009372 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 645657009373 FeS assembly protein SufD; Region: sufD; TIGR01981 645657009374 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 645657009375 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 645657009376 Walker A/P-loop; other site 645657009377 ATP binding site [chemical binding]; other site 645657009378 Q-loop/lid; other site 645657009379 ABC transporter signature motif; other site 645657009380 Walker B; other site 645657009381 D-loop; other site 645657009382 H-loop/switch region; other site 645657009383 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 645657009384 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 645657009385 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 645657009386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657009387 conserved gate region; other site 645657009388 ABC-ATPase subunit interface; other site 645657009389 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 645657009390 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 645657009391 Walker A/P-loop; other site 645657009392 ATP binding site [chemical binding]; other site 645657009393 Q-loop/lid; other site 645657009394 ABC transporter signature motif; other site 645657009395 Walker B; other site 645657009396 D-loop; other site 645657009397 H-loop/switch region; other site 645657009398 NIL domain; Region: NIL; pfam09383 645657009399 SCP-2 sterol transfer family; Region: SCP2; pfam02036 645657009400 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 645657009401 catalytic residues [active] 645657009402 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 645657009403 putative active site [active] 645657009404 putative metal binding site [ion binding]; other site 645657009405 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 645657009406 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 645657009407 lipoyl attachment site [posttranslational modification]; other site 645657009408 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 645657009409 ArsC family; Region: ArsC; pfam03960 645657009410 putative ArsC-like catalytic residues; other site 645657009411 putative TRX-like catalytic residues [active] 645657009412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 645657009413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 645657009414 active site 645657009415 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 645657009416 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 645657009417 dimer interface [polypeptide binding]; other site 645657009418 active site 645657009419 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 645657009420 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 645657009421 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 645657009422 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 645657009423 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 645657009424 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 645657009425 substrate binding site [chemical binding]; other site 645657009426 oxyanion hole (OAH) forming residues; other site 645657009427 trimer interface [polypeptide binding]; other site 645657009428 Proline dehydrogenase; Region: Pro_dh; pfam01619 645657009429 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 645657009430 dinuclear metal binding motif [ion binding]; other site 645657009431 Coat F domain; Region: Coat_F; pfam07875 645657009432 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657009433 MarR family; Region: MarR; pfam01047 645657009434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657009435 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657009436 putative substrate translocation pore; other site 645657009437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657009438 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 645657009439 classical (c) SDRs; Region: SDR_c; cd05233 645657009440 NAD(P) binding site [chemical binding]; other site 645657009441 active site 645657009442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657009443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657009444 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 645657009445 dimerization interface [polypeptide binding]; other site 645657009446 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 645657009447 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 645657009448 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 645657009449 Walker A/P-loop; other site 645657009450 ATP binding site [chemical binding]; other site 645657009451 Q-loop/lid; other site 645657009452 ABC transporter signature motif; other site 645657009453 Walker B; other site 645657009454 D-loop; other site 645657009455 H-loop/switch region; other site 645657009456 YusW-like protein; Region: YusW; pfam14039 645657009457 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 645657009458 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 645657009459 active site 645657009460 Zn binding site [ion binding]; other site 645657009461 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 645657009462 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645657009463 Walker A/P-loop; other site 645657009464 ATP binding site [chemical binding]; other site 645657009465 Q-loop/lid; other site 645657009466 ABC transporter signature motif; other site 645657009467 Walker B; other site 645657009468 D-loop; other site 645657009469 H-loop/switch region; other site 645657009470 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 645657009471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657009472 S-adenosylmethionine binding site [chemical binding]; other site 645657009473 H+ Antiporter protein; Region: 2A0121; TIGR00900 645657009474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657009475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657009476 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 645657009477 Coenzyme A binding pocket [chemical binding]; other site 645657009478 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 645657009479 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 645657009480 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 645657009481 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 645657009482 substrate-cofactor binding pocket; other site 645657009483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657009484 catalytic residue [active] 645657009485 short chain dehydrogenase; Provisional; Region: PRK06914 645657009486 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 645657009487 NADP binding site [chemical binding]; other site 645657009488 active site 645657009489 steroid binding site; other site 645657009490 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 645657009491 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 645657009492 dimerization interface [polypeptide binding]; other site 645657009493 DPS ferroxidase diiron center [ion binding]; other site 645657009494 ion pore; other site 645657009495 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 645657009496 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 645657009497 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 645657009498 protein binding site [polypeptide binding]; other site 645657009499 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645657009500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657009501 active site 645657009502 phosphorylation site [posttranslational modification] 645657009503 intermolecular recognition site; other site 645657009504 dimerization interface [polypeptide binding]; other site 645657009505 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645657009506 DNA binding site [nucleotide binding] 645657009507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645657009508 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645657009509 dimerization interface [polypeptide binding]; other site 645657009510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657009511 dimer interface [polypeptide binding]; other site 645657009512 phosphorylation site [posttranslational modification] 645657009513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657009514 ATP binding site [chemical binding]; other site 645657009515 Mg2+ binding site [ion binding]; other site 645657009516 G-X-G motif; other site 645657009517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657009518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657009519 fumarate hydratase; Reviewed; Region: fumC; PRK00485 645657009520 Class II fumarases; Region: Fumarase_classII; cd01362 645657009521 active site 645657009522 tetramer interface [polypeptide binding]; other site 645657009523 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 645657009524 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 645657009525 Spore germination protein; Region: Spore_permease; pfam03845 645657009526 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 645657009527 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 645657009528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645657009529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657009530 active site 645657009531 phosphorylation site [posttranslational modification] 645657009532 intermolecular recognition site; other site 645657009533 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645657009534 DNA binding residues [nucleotide binding] 645657009535 dimerization interface [polypeptide binding]; other site 645657009536 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 645657009537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645657009538 dimerization interface [polypeptide binding]; other site 645657009539 Histidine kinase; Region: HisKA_3; pfam07730 645657009540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657009541 ATP binding site [chemical binding]; other site 645657009542 Mg2+ binding site [ion binding]; other site 645657009543 G-X-G motif; other site 645657009544 Predicted membrane protein [Function unknown]; Region: COG4758 645657009545 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 645657009546 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 645657009547 Uncharacterized conserved protein [Function unknown]; Region: COG3595 645657009548 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 645657009549 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 645657009550 PspA/IM30 family; Region: PspA_IM30; pfam04012 645657009551 H+ Antiporter protein; Region: 2A0121; TIGR00900 645657009552 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 645657009553 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 645657009554 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 645657009555 Walker A/P-loop; other site 645657009556 ATP binding site [chemical binding]; other site 645657009557 Q-loop/lid; other site 645657009558 ABC transporter signature motif; other site 645657009559 Walker B; other site 645657009560 D-loop; other site 645657009561 H-loop/switch region; other site 645657009562 Adenosylcobinamide amidohydrolase [Coenzyme metabolism]; Region: cbiZ; COG1865 645657009563 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 645657009564 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645657009565 ABC-ATPase subunit interface; other site 645657009566 dimer interface [polypeptide binding]; other site 645657009567 putative PBP binding regions; other site 645657009568 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 645657009569 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 645657009570 putative binding site residues; other site 645657009571 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 645657009572 classical (c) SDRs; Region: SDR_c; cd05233 645657009573 NAD(P) binding site [chemical binding]; other site 645657009574 active site 645657009575 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 645657009576 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645657009577 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657009578 dimer interface [polypeptide binding]; other site 645657009579 phosphorylation site [posttranslational modification] 645657009580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657009581 ATP binding site [chemical binding]; other site 645657009582 Mg2+ binding site [ion binding]; other site 645657009583 G-X-G motif; other site 645657009584 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645657009585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657009586 active site 645657009587 phosphorylation site [posttranslational modification] 645657009588 intermolecular recognition site; other site 645657009589 dimerization interface [polypeptide binding]; other site 645657009590 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645657009591 DNA binding site [nucleotide binding] 645657009592 hypothetical protein; Provisional; Region: PRK14082 645657009593 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 645657009594 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657009595 DNA binding residues [nucleotide binding] 645657009596 YvrJ protein family; Region: YvrJ; pfam12841 645657009597 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 645657009598 Cupin; Region: Cupin_1; smart00835 645657009599 Cupin; Region: Cupin_1; smart00835 645657009600 Regulatory protein YrvL; Region: YrvL; pfam14184 645657009601 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645657009602 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645657009603 FtsX-like permease family; Region: FtsX; pfam02687 645657009604 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645657009605 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645657009606 Walker A/P-loop; other site 645657009607 ATP binding site [chemical binding]; other site 645657009608 Q-loop/lid; other site 645657009609 ABC transporter signature motif; other site 645657009610 Walker B; other site 645657009611 D-loop; other site 645657009612 H-loop/switch region; other site 645657009613 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 645657009614 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 645657009615 DNA damage checkpoint protein; Region: LCD1; pfam09798 645657009616 HlyD family secretion protein; Region: HlyD_3; pfam13437 645657009617 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 645657009618 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 645657009619 Walker A/P-loop; other site 645657009620 ATP binding site [chemical binding]; other site 645657009621 Q-loop/lid; other site 645657009622 ABC transporter signature motif; other site 645657009623 Walker B; other site 645657009624 D-loop; other site 645657009625 H-loop/switch region; other site 645657009626 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 645657009627 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645657009628 ABC-ATPase subunit interface; other site 645657009629 dimer interface [polypeptide binding]; other site 645657009630 putative PBP binding regions; other site 645657009631 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 645657009632 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645657009633 ABC-ATPase subunit interface; other site 645657009634 dimer interface [polypeptide binding]; other site 645657009635 putative PBP binding regions; other site 645657009636 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 645657009637 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 645657009638 putative ligand binding residues [chemical binding]; other site 645657009639 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 645657009640 Spore germination protein; Region: Spore_permease; cl17796 645657009641 small, acid-soluble spore protein, SspJ family; Region: spore_sspJ; TIGR02863 645657009642 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 645657009643 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 645657009644 Sulfatase; Region: Sulfatase; pfam00884 645657009645 DNA binding domain, excisionase family; Region: excise; TIGR01764 645657009646 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 645657009647 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 645657009648 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 645657009649 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 645657009650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657009651 dimer interface [polypeptide binding]; other site 645657009652 conserved gate region; other site 645657009653 putative PBP binding loops; other site 645657009654 ABC-ATPase subunit interface; other site 645657009655 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645657009656 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645657009657 active site 645657009658 catalytic tetrad [active] 645657009659 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 645657009660 sulfite reductase subunit beta; Provisional; Region: PRK13504 645657009661 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 645657009662 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 645657009663 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 645657009664 Flavodoxin; Region: Flavodoxin_1; pfam00258 645657009665 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 645657009666 FAD binding pocket [chemical binding]; other site 645657009667 FAD binding motif [chemical binding]; other site 645657009668 catalytic residues [active] 645657009669 NAD binding pocket [chemical binding]; other site 645657009670 phosphate binding motif [ion binding]; other site 645657009671 beta-alpha-beta structure motif; other site 645657009672 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 645657009673 Part of AAA domain; Region: AAA_19; pfam13245 645657009674 Family description; Region: UvrD_C_2; pfam13538 645657009675 Predicted membrane protein [Function unknown]; Region: COG2860 645657009676 UPF0126 domain; Region: UPF0126; pfam03458 645657009677 UPF0126 domain; Region: UPF0126; pfam03458 645657009678 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 645657009679 Thioredoxin; Region: Thioredoxin_4; pfam13462 645657009680 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 645657009681 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 645657009682 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 645657009683 metal-binding site [ion binding] 645657009684 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645657009685 Soluble P-type ATPase [General function prediction only]; Region: COG4087 645657009686 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 645657009687 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 645657009688 metal-binding site [ion binding] 645657009689 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 645657009690 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 645657009691 metal-binding site [ion binding] 645657009692 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645657009693 Soluble P-type ATPase [General function prediction only]; Region: COG4087 645657009694 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 645657009695 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 645657009696 metal-binding site [ion binding] 645657009697 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 645657009698 putative homodimer interface [polypeptide binding]; other site 645657009699 putative homotetramer interface [polypeptide binding]; other site 645657009700 allosteric switch controlling residues; other site 645657009701 putative metal binding site [ion binding]; other site 645657009702 putative homodimer-homodimer interface [polypeptide binding]; other site 645657009703 putative oxidoreductase; Provisional; Region: PRK11579 645657009704 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 645657009705 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 645657009706 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 645657009707 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 645657009708 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 645657009709 Predicted membrane protein [Function unknown]; Region: COG1289 645657009710 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 645657009711 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 645657009712 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 645657009713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657009714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657009715 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 645657009716 classical (c) SDRs; Region: SDR_c; cd05233 645657009717 NAD(P) binding site [chemical binding]; other site 645657009718 active site 645657009719 LXG domain of WXG superfamily; Region: LXG; pfam04740 645657009720 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 645657009721 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 645657009722 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 645657009723 amidase catalytic site [active] 645657009724 Zn binding residues [ion binding]; other site 645657009725 substrate binding site [chemical binding]; other site 645657009726 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657009727 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 645657009728 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 645657009729 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 645657009730 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 645657009731 YopX protein; Region: YopX; pfam09643 645657009732 dUTPase; Region: dUTPase_2; pfam08761 645657009733 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 645657009734 active site 645657009735 homodimer interface [polypeptide binding]; other site 645657009736 metal binding site [ion binding]; metal-binding site 645657009737 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 645657009738 peptide chain release factor 1; Provisional; Region: PRK04011 645657009739 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 645657009740 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 645657009741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657009742 Walker A motif; other site 645657009743 ATP binding site [chemical binding]; other site 645657009744 Walker B motif; other site 645657009745 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 645657009746 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 645657009747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657009748 non-specific DNA binding site [nucleotide binding]; other site 645657009749 salt bridge; other site 645657009750 sequence-specific DNA binding site [nucleotide binding]; other site 645657009751 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645657009752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657009753 non-specific DNA binding site [nucleotide binding]; other site 645657009754 salt bridge; other site 645657009755 sequence-specific DNA binding site [nucleotide binding]; other site 645657009756 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645657009757 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 645657009758 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 645657009759 Int/Topo IB signature motif; other site 645657009760 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 645657009761 SmpB-tmRNA interface; other site 645657009762 ribonuclease R; Region: RNase_R; TIGR02063 645657009763 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 645657009764 Cold shock protein domain; Region: CSP; smart00357 645657009765 RNB domain; Region: RNB; pfam00773 645657009766 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 645657009767 RNA binding site [nucleotide binding]; other site 645657009768 Esterase/lipase [General function prediction only]; Region: COG1647 645657009769 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 645657009770 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 645657009771 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657009772 sequence-specific DNA binding site [nucleotide binding]; other site 645657009773 salt bridge; other site 645657009774 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645657009775 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657009776 non-specific DNA binding site [nucleotide binding]; other site 645657009777 salt bridge; other site 645657009778 sequence-specific DNA binding site [nucleotide binding]; other site 645657009779 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645657009780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657009781 non-specific DNA binding site [nucleotide binding]; other site 645657009782 salt bridge; other site 645657009783 sequence-specific DNA binding site [nucleotide binding]; other site 645657009784 Predicted transcriptional regulators [Transcription]; Region: COG1733 645657009785 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 645657009786 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 645657009787 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645657009788 dimerization interface [polypeptide binding]; other site 645657009789 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 645657009790 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 645657009791 dimer interface [polypeptide binding]; other site 645657009792 putative CheW interface [polypeptide binding]; other site 645657009793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657009794 dimer interface [polypeptide binding]; other site 645657009795 conserved gate region; other site 645657009796 putative PBP binding loops; other site 645657009797 ABC-ATPase subunit interface; other site 645657009798 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 645657009799 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 645657009800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657009801 dimer interface [polypeptide binding]; other site 645657009802 conserved gate region; other site 645657009803 putative PBP binding loops; other site 645657009804 ABC-ATPase subunit interface; other site 645657009805 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 645657009806 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 645657009807 Walker A/P-loop; other site 645657009808 ATP binding site [chemical binding]; other site 645657009809 Q-loop/lid; other site 645657009810 ABC transporter signature motif; other site 645657009811 Walker B; other site 645657009812 D-loop; other site 645657009813 H-loop/switch region; other site 645657009814 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 645657009815 Predicted transcriptional regulators [Transcription]; Region: COG1510 645657009816 MarR family; Region: MarR_2; pfam12802 645657009817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657009818 dimer interface [polypeptide binding]; other site 645657009819 conserved gate region; other site 645657009820 putative PBP binding loops; other site 645657009821 ABC-ATPase subunit interface; other site 645657009822 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 645657009823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657009824 dimer interface [polypeptide binding]; other site 645657009825 conserved gate region; other site 645657009826 putative PBP binding loops; other site 645657009827 ABC-ATPase subunit interface; other site 645657009828 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 645657009829 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 645657009830 Walker A/P-loop; other site 645657009831 ATP binding site [chemical binding]; other site 645657009832 Q-loop/lid; other site 645657009833 ABC transporter signature motif; other site 645657009834 Walker B; other site 645657009835 D-loop; other site 645657009836 H-loop/switch region; other site 645657009837 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 645657009838 Predicted transcriptional regulators [Transcription]; Region: COG1510 645657009839 MarR family; Region: MarR_2; pfam12802 645657009840 membrane protein, MarC family; Region: TIGR00427 645657009841 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 645657009842 pentamer interface [polypeptide binding]; other site 645657009843 dodecaamer interface [polypeptide binding]; other site 645657009844 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 645657009845 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 645657009846 Double zinc ribbon; Region: DZR; pfam12773 645657009847 Predicted membrane protein [Function unknown]; Region: COG4640 645657009848 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 645657009849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657009850 Coenzyme A binding pocket [chemical binding]; other site 645657009851 enolase; Provisional; Region: eno; PRK00077 645657009852 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 645657009853 dimer interface [polypeptide binding]; other site 645657009854 metal binding site [ion binding]; metal-binding site 645657009855 substrate binding pocket [chemical binding]; other site 645657009856 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 645657009857 phosphoglyceromutase; Provisional; Region: PRK05434 645657009858 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 645657009859 triosephosphate isomerase; Provisional; Region: PRK14565 645657009860 substrate binding site [chemical binding]; other site 645657009861 dimer interface [polypeptide binding]; other site 645657009862 catalytic triad [active] 645657009863 Phosphoglycerate kinase; Region: PGK; pfam00162 645657009864 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 645657009865 substrate binding site [chemical binding]; other site 645657009866 hinge regions; other site 645657009867 ADP binding site [chemical binding]; other site 645657009868 catalytic site [active] 645657009869 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 645657009870 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 645657009871 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 645657009872 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 645657009873 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 645657009874 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 645657009875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657009876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657009877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657009878 DNA-binding site [nucleotide binding]; DNA binding site 645657009879 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645657009880 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 645657009881 putative dimerization interface [polypeptide binding]; other site 645657009882 putative ligand binding site [chemical binding]; other site 645657009883 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 645657009884 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 645657009885 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 645657009886 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657009887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657009888 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 645657009889 dimerization interface [polypeptide binding]; other site 645657009890 EamA-like transporter family; Region: EamA; pfam00892 645657009891 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 645657009892 EamA-like transporter family; Region: EamA; pfam00892 645657009893 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 645657009894 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 645657009895 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 645657009896 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 645657009897 active site 645657009898 Uncharacterized conserved protein [Function unknown]; Region: COG1556 645657009899 iron-sulfur cluster-binding protein; Region: TIGR00273 645657009900 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 645657009901 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 645657009902 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 645657009903 Cysteine-rich domain; Region: CCG; pfam02754 645657009904 Cysteine-rich domain; Region: CCG; pfam02754 645657009905 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645657009906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657009907 active site 645657009908 phosphorylation site [posttranslational modification] 645657009909 intermolecular recognition site; other site 645657009910 dimerization interface [polypeptide binding]; other site 645657009911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645657009912 DNA binding residues [nucleotide binding] 645657009913 dimerization interface [polypeptide binding]; other site 645657009914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 645657009915 Histidine kinase; Region: HisKA_3; pfam07730 645657009916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657009917 ATP binding site [chemical binding]; other site 645657009918 Mg2+ binding site [ion binding]; other site 645657009919 G-X-G motif; other site 645657009920 ABC-2 type transporter; Region: ABC2_membrane; cl17235 645657009921 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645657009922 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645657009923 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645657009924 Walker A/P-loop; other site 645657009925 ATP binding site [chemical binding]; other site 645657009926 Q-loop/lid; other site 645657009927 ABC transporter signature motif; other site 645657009928 Walker B; other site 645657009929 D-loop; other site 645657009930 H-loop/switch region; other site 645657009931 AAA domain; Region: AAA_17; pfam13207 645657009932 Uncharacterized conserved protein [Function unknown]; Region: COG4933 645657009933 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 645657009934 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 645657009935 catalytic site [active] 645657009936 PAS domain S-box; Region: sensory_box; TIGR00229 645657009937 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657009938 putative active site [active] 645657009939 heme pocket [chemical binding]; other site 645657009940 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 645657009941 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 645657009942 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 645657009943 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 645657009944 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 645657009945 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 645657009946 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 645657009947 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 645657009948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657009949 dimer interface [polypeptide binding]; other site 645657009950 conserved gate region; other site 645657009951 putative PBP binding loops; other site 645657009952 ABC-ATPase subunit interface; other site 645657009953 TM2 domain; Region: TM2; pfam05154 645657009954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657009955 dimer interface [polypeptide binding]; other site 645657009956 conserved gate region; other site 645657009957 ABC-ATPase subunit interface; other site 645657009958 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 645657009959 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 645657009960 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645657009961 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645657009962 DNA binding site [nucleotide binding] 645657009963 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 645657009964 putative dimerization interface [polypeptide binding]; other site 645657009965 putative ligand binding site [chemical binding]; other site 645657009966 Transcriptional regulators [Transcription]; Region: FadR; COG2186 645657009967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657009968 DNA-binding site [nucleotide binding]; DNA binding site 645657009969 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 645657009970 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 645657009971 L-lactate permease; Region: Lactate_perm; pfam02652 645657009972 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 645657009973 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 645657009974 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 645657009975 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 645657009976 YvfG protein; Region: YvfG; pfam09628 645657009977 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 645657009978 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 645657009979 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 645657009980 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 645657009981 inhibitor-cofactor binding pocket; inhibition site 645657009982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657009983 catalytic residue [active] 645657009984 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 645657009985 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 645657009986 putative trimer interface [polypeptide binding]; other site 645657009987 putative CoA binding site [chemical binding]; other site 645657009988 Bacterial sugar transferase; Region: Bac_transf; pfam02397 645657009989 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 645657009990 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 645657009991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 645657009992 active site 645657009993 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 645657009994 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 645657009995 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 645657009996 active site 645657009997 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645657009998 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 645657009999 putative ADP-binding pocket [chemical binding]; other site 645657010000 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 645657010001 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 645657010002 active site 645657010003 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 645657010004 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645657010005 putative ADP-binding pocket [chemical binding]; other site 645657010006 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 645657010007 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 645657010008 NAD(P) binding site [chemical binding]; other site 645657010009 homodimer interface [polypeptide binding]; other site 645657010010 substrate binding site [chemical binding]; other site 645657010011 active site 645657010012 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 645657010013 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 645657010014 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 645657010015 Chain length determinant protein; Region: Wzz; cl15801 645657010016 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645657010017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645657010018 non-specific DNA binding site [nucleotide binding]; other site 645657010019 salt bridge; other site 645657010020 sequence-specific DNA binding site [nucleotide binding]; other site 645657010021 Anti-repressor SinI; Region: SinI; pfam08671 645657010022 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 645657010023 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 645657010024 substrate binding pocket [chemical binding]; other site 645657010025 catalytic triad [active] 645657010026 Phenolic acid decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3479 645657010027 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 645657010028 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 645657010029 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 645657010030 aspartate racemase; Region: asp_race; TIGR00035 645657010031 Beta-lactamase; Region: Beta-lactamase; pfam00144 645657010032 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 645657010033 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 645657010034 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 645657010035 Beta-lactamase; Region: Beta-lactamase; pfam00144 645657010036 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 645657010037 active site 645657010038 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 645657010039 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 645657010040 substrate binding [chemical binding]; other site 645657010041 active site 645657010042 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 645657010043 amino acid transporter; Region: 2A0306; TIGR00909 645657010044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657010045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657010046 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 645657010047 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 645657010048 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 645657010049 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 645657010050 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 645657010051 Replication-relaxation; Region: Replic_Relax; pfam13814 645657010052 Phage holin; Region: Phage_holin_5; pfam06946 645657010053 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 645657010054 amidase catalytic site [active] 645657010055 Zn binding residues [ion binding]; other site 645657010056 substrate binding site [chemical binding]; other site 645657010057 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645657010058 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 645657010059 integron integrase; Region: integrase_gron; TIGR02249 645657010060 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645657010061 active site 645657010062 DNA binding site [nucleotide binding] 645657010063 Int/Topo IB signature motif; other site 645657010064 Clp protease; Region: CLP_protease; pfam00574 645657010065 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 645657010066 oligomer interface [polypeptide binding]; other site 645657010067 active site residues [active] 645657010068 beta-phosphoglucomutase; Region: bPGM; TIGR01990 645657010069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657010070 motif II; other site 645657010071 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 645657010072 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 645657010073 Ca binding site [ion binding]; other site 645657010074 active site 645657010075 catalytic site [active] 645657010076 maltose phosphorylase; Provisional; Region: PRK13807 645657010077 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 645657010078 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 645657010079 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 645657010080 Predicted integral membrane protein [Function unknown]; Region: COG5521 645657010081 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 645657010082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657010083 dimer interface [polypeptide binding]; other site 645657010084 conserved gate region; other site 645657010085 ABC-ATPase subunit interface; other site 645657010086 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 645657010087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657010088 dimer interface [polypeptide binding]; other site 645657010089 conserved gate region; other site 645657010090 putative PBP binding loops; other site 645657010091 ABC-ATPase subunit interface; other site 645657010092 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 645657010093 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 645657010094 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 645657010095 homodimer interface [polypeptide binding]; other site 645657010096 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 645657010097 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 645657010098 active site 645657010099 homodimer interface [polypeptide binding]; other site 645657010100 catalytic site [active] 645657010101 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645657010102 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645657010103 DNA binding site [nucleotide binding] 645657010104 domain linker motif; other site 645657010105 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 645657010106 ligand binding site [chemical binding]; other site 645657010107 dimerization interface [polypeptide binding]; other site 645657010108 TIGR00730 family protein; Region: TIGR00730 645657010109 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 645657010110 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 645657010111 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 645657010112 Sulfate transporter family; Region: Sulfate_transp; pfam00916 645657010113 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 645657010114 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 645657010115 active site clefts [active] 645657010116 zinc binding site [ion binding]; other site 645657010117 dimer interface [polypeptide binding]; other site 645657010118 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 645657010119 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 645657010120 dimerization interface [polypeptide binding]; other site 645657010121 ligand binding site [chemical binding]; other site 645657010122 NADP binding site [chemical binding]; other site 645657010123 catalytic site [active] 645657010124 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645657010125 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645657010126 Walker A/P-loop; other site 645657010127 ATP binding site [chemical binding]; other site 645657010128 Q-loop/lid; other site 645657010129 ABC transporter signature motif; other site 645657010130 Walker B; other site 645657010131 D-loop; other site 645657010132 H-loop/switch region; other site 645657010133 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645657010134 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 645657010135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657010136 ATP binding site [chemical binding]; other site 645657010137 Mg2+ binding site [ion binding]; other site 645657010138 G-X-G motif; other site 645657010139 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645657010140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657010141 active site 645657010142 phosphorylation site [posttranslational modification] 645657010143 intermolecular recognition site; other site 645657010144 dimerization interface [polypeptide binding]; other site 645657010145 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645657010146 DNA binding site [nucleotide binding] 645657010147 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 645657010148 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 645657010149 dimerization domain swap beta strand [polypeptide binding]; other site 645657010150 regulatory protein interface [polypeptide binding]; other site 645657010151 active site 645657010152 regulatory phosphorylation site [posttranslational modification]; other site 645657010153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 645657010154 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 645657010155 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 645657010156 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 645657010157 phosphate binding site [ion binding]; other site 645657010158 putative substrate binding pocket [chemical binding]; other site 645657010159 dimer interface [polypeptide binding]; other site 645657010160 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 645657010161 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 645657010162 putative active site [active] 645657010163 nucleotide binding site [chemical binding]; other site 645657010164 nudix motif; other site 645657010165 putative metal binding site [ion binding]; other site 645657010166 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 645657010167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645657010168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645657010169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 645657010170 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645657010171 NlpC/P60 family; Region: NLPC_P60; pfam00877 645657010172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657010173 binding surface 645657010174 Tetratricopeptide repeat; Region: TPR_16; pfam13432 645657010175 TPR motif; other site 645657010176 Tetratricopeptide repeat; Region: TPR_16; pfam13432 645657010177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657010178 TPR motif; other site 645657010179 binding surface 645657010180 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645657010181 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645657010182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657010183 Walker A/P-loop; other site 645657010184 ATP binding site [chemical binding]; other site 645657010185 Q-loop/lid; other site 645657010186 ABC transporter signature motif; other site 645657010187 Walker B; other site 645657010188 D-loop; other site 645657010189 H-loop/switch region; other site 645657010190 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 645657010191 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 645657010192 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 645657010193 metal binding site [ion binding]; metal-binding site 645657010194 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 645657010195 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 645657010196 substrate binding site [chemical binding]; other site 645657010197 glutamase interaction surface [polypeptide binding]; other site 645657010198 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 645657010199 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 645657010200 catalytic residues [active] 645657010201 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 645657010202 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 645657010203 putative active site [active] 645657010204 oxyanion strand; other site 645657010205 catalytic triad [active] 645657010206 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 645657010207 putative active site pocket [active] 645657010208 4-fold oligomerization interface [polypeptide binding]; other site 645657010209 metal binding residues [ion binding]; metal-binding site 645657010210 3-fold/trimer interface [polypeptide binding]; other site 645657010211 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 645657010212 histidinol dehydrogenase; Region: hisD; TIGR00069 645657010213 NAD binding site [chemical binding]; other site 645657010214 dimerization interface [polypeptide binding]; other site 645657010215 product binding site; other site 645657010216 substrate binding site [chemical binding]; other site 645657010217 zinc binding site [ion binding]; other site 645657010218 catalytic residues [active] 645657010219 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 645657010220 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 645657010221 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 645657010222 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 645657010223 dimer interface [polypeptide binding]; other site 645657010224 motif 1; other site 645657010225 active site 645657010226 motif 2; other site 645657010227 motif 3; other site 645657010228 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 645657010229 putative active site [active] 645657010230 Pectate lyase; Region: Pectate_lyase; pfam03211 645657010231 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 645657010232 Homeodomain-like domain; Region: HTH_23; pfam13384 645657010233 putative transposase OrfB; Reviewed; Region: PHA02517 645657010234 HTH-like domain; Region: HTH_21; pfam13276 645657010235 Integrase core domain; Region: rve; pfam00665 645657010236 Integrase core domain; Region: rve_3; pfam13683 645657010237 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 645657010238 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 645657010239 CoA binding site [chemical binding]; other site 645657010240 active site 645657010241 pyrophosphatase PpaX; Provisional; Region: PRK13288 645657010242 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 645657010243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657010244 motif II; other site 645657010245 Nucleoside recognition; Region: Gate; pfam07670 645657010246 Nucleoside recognition; Region: Gate; pfam07670 645657010247 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 645657010248 HPr kinase/phosphorylase; Provisional; Region: PRK05428 645657010249 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 645657010250 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 645657010251 Hpr binding site; other site 645657010252 active site 645657010253 homohexamer subunit interaction site [polypeptide binding]; other site 645657010254 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 645657010255 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 645657010256 active site 645657010257 dimer interface [polypeptide binding]; other site 645657010258 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 645657010259 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 645657010260 active site 645657010261 trimer interface [polypeptide binding]; other site 645657010262 allosteric site; other site 645657010263 active site lid [active] 645657010264 hexamer (dimer of trimers) interface [polypeptide binding]; other site 645657010265 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 645657010266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657010267 DNA-binding site [nucleotide binding]; DNA binding site 645657010268 UTRA domain; Region: UTRA; pfam07702 645657010269 Lamin Tail Domain; Region: LTD; pfam00932 645657010270 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 645657010271 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 645657010272 putative active site [active] 645657010273 putative metal binding site [ion binding]; other site 645657010274 Transposase domain (DUF772); Region: DUF772; pfam05598 645657010275 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 645657010276 Predicted membrane protein [Function unknown]; Region: COG1950 645657010277 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 645657010278 Uncharacterized conserved protein [Function unknown]; Region: COG3595 645657010279 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 645657010280 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 645657010281 flagellin; Provisional; Region: PRK12804 645657010282 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 645657010283 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 645657010284 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 645657010285 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 645657010286 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 645657010287 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 645657010288 excinuclease ABC subunit B; Provisional; Region: PRK05298 645657010289 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645657010290 ATP binding site [chemical binding]; other site 645657010291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657010292 nucleotide binding region [chemical binding]; other site 645657010293 ATP-binding site [chemical binding]; other site 645657010294 Ultra-violet resistance protein B; Region: UvrB; pfam12344 645657010295 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 645657010296 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 645657010297 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 645657010298 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 645657010299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657010300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657010301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657010302 putative substrate translocation pore; other site 645657010303 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 645657010304 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 645657010305 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 645657010306 C-terminal peptidase (prc); Region: prc; TIGR00225 645657010307 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 645657010308 protein binding site [polypeptide binding]; other site 645657010309 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 645657010310 Catalytic dyad [active] 645657010311 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 645657010312 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 645657010313 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 645657010314 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 645657010315 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 645657010316 Walker A/P-loop; other site 645657010317 ATP binding site [chemical binding]; other site 645657010318 Q-loop/lid; other site 645657010319 ABC transporter signature motif; other site 645657010320 Walker B; other site 645657010321 D-loop; other site 645657010322 H-loop/switch region; other site 645657010323 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 645657010324 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 645657010325 Uncharacterized conserved protein [Function unknown]; Region: COG1284 645657010326 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645657010327 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645657010328 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 645657010329 peptide chain release factor 2; Provisional; Region: PRK06746 645657010330 This domain is found in peptide chain release factors; Region: PCRF; smart00937 645657010331 RF-1 domain; Region: RF-1; pfam00472 645657010332 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 645657010333 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 645657010334 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 645657010335 nucleotide binding region [chemical binding]; other site 645657010336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 645657010337 ATP-binding site [chemical binding]; other site 645657010338 SEC-C motif; Region: SEC-C; pfam02810 645657010339 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 645657010340 30S subunit binding site; other site 645657010341 Flagellar protein FliT; Region: FliT; pfam05400 645657010342 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 645657010343 flagellar capping protein; Validated; Region: fliD; PRK07737 645657010344 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 645657010345 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 645657010346 FlaG protein; Region: FlaG; cl00591 645657010347 flagellin; Provisional; Region: PRK12804 645657010348 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 645657010349 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 645657010350 carbon storage regulator; Provisional; Region: PRK01712 645657010351 flagellar assembly protein FliW; Provisional; Region: PRK13285 645657010352 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 645657010353 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 645657010354 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 645657010355 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 645657010356 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 645657010357 FlgN protein; Region: FlgN; pfam05130 645657010358 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 645657010359 flagellar operon protein TIGR03826; Region: YvyF 645657010360 comF family protein; Region: comF; TIGR00201 645657010361 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645657010362 active site 645657010363 Late competence development protein ComFB; Region: ComFB; pfam10719 645657010364 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 645657010365 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645657010366 ATP binding site [chemical binding]; other site 645657010367 putative Mg++ binding site [ion binding]; other site 645657010368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657010369 nucleotide binding region [chemical binding]; other site 645657010370 ATP-binding site [chemical binding]; other site 645657010371 EDD domain protein, DegV family; Region: DegV; TIGR00762 645657010372 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 645657010373 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645657010374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657010375 active site 645657010376 phosphorylation site [posttranslational modification] 645657010377 intermolecular recognition site; other site 645657010378 dimerization interface [polypeptide binding]; other site 645657010379 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645657010380 DNA binding residues [nucleotide binding] 645657010381 dimerization interface [polypeptide binding]; other site 645657010382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 645657010383 Histidine kinase; Region: HisKA_3; pfam07730 645657010384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657010385 ATP binding site [chemical binding]; other site 645657010386 Mg2+ binding site [ion binding]; other site 645657010387 G-X-G motif; other site 645657010388 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 645657010389 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 645657010390 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 645657010391 Transcriptional regulator [Transcription]; Region: LytR; COG1316 645657010392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657010393 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 645657010394 Walker A/P-loop; other site 645657010395 ATP binding site [chemical binding]; other site 645657010396 Q-loop/lid; other site 645657010397 ABC transporter signature motif; other site 645657010398 Walker B; other site 645657010399 D-loop; other site 645657010400 H-loop/switch region; other site 645657010401 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 645657010402 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 645657010403 Mg++ binding site [ion binding]; other site 645657010404 putative catalytic motif [active] 645657010405 substrate binding site [chemical binding]; other site 645657010406 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 645657010407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645657010408 putative homodimer interface [polypeptide binding]; other site 645657010409 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 645657010410 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 645657010411 active site 645657010412 O-Antigen ligase; Region: Wzy_C; pfam04932 645657010413 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 645657010414 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 645657010415 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 645657010416 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645657010417 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 645657010418 colanic acid exporter; Provisional; Region: PRK10459 645657010419 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 645657010420 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 645657010421 Bacterial sugar transferase; Region: Bac_transf; pfam02397 645657010422 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 645657010423 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 645657010424 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 645657010425 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645657010426 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 645657010427 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645657010428 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645657010429 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 645657010430 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645657010431 active site 645657010432 metal binding site [ion binding]; metal-binding site 645657010433 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645657010434 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 645657010435 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645657010436 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645657010437 Stage II sporulation protein; Region: SpoIID; pfam08486 645657010438 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 645657010439 Transposase domain (DUF772); Region: DUF772; pfam05598 645657010440 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 645657010441 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 645657010442 active site 645657010443 homodimer interface [polypeptide binding]; other site 645657010444 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 645657010445 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 645657010446 active site 645657010447 tetramer interface; other site 645657010448 putative transposase OrfB; Reviewed; Region: PHA02517 645657010449 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 645657010450 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 645657010451 Walker A/P-loop; other site 645657010452 ATP binding site [chemical binding]; other site 645657010453 Q-loop/lid; other site 645657010454 ABC transporter signature motif; other site 645657010455 Walker B; other site 645657010456 D-loop; other site 645657010457 H-loop/switch region; other site 645657010458 Topoisomer_IB_N: N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I and heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into: topo type IA; Region: Topoisomer_IB_N; cl02774 645657010459 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 645657010460 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 645657010461 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 645657010462 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 645657010463 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 645657010464 putative ADP-binding pocket [chemical binding]; other site 645657010465 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645657010466 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 645657010467 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 645657010468 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 645657010469 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 645657010470 active site 645657010471 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 645657010472 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 645657010473 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 645657010474 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 645657010475 Bacterial SH3 domain; Region: SH3_3; pfam08239 645657010476 Lysozyme subfamily 2; Region: LYZ2; smart00047 645657010477 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 645657010478 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 645657010479 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 645657010480 Spore germination protein; Region: Spore_permease; pfam03845 645657010481 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 645657010482 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 645657010483 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 645657010484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657010485 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657010486 putative substrate translocation pore; other site 645657010487 Transcriptional regulator [Transcription]; Region: LytR; COG1316 645657010488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657010489 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 645657010490 active site 645657010491 motif I; other site 645657010492 motif II; other site 645657010493 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 645657010494 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645657010495 NlpC/P60 family; Region: NLPC_P60; pfam00877 645657010496 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645657010497 NlpC/P60 family; Region: NLPC_P60; pfam00877 645657010498 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645657010499 NlpC/P60 family; Region: NLPC_P60; pfam00877 645657010500 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 645657010501 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 645657010502 putative active site [active] 645657010503 putative metal binding site [ion binding]; other site 645657010504 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 645657010505 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 645657010506 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645657010507 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645657010508 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645657010509 DNA binding site [nucleotide binding] 645657010510 domain linker motif; other site 645657010511 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 645657010512 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 645657010513 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 645657010514 substrate binding site [chemical binding]; other site 645657010515 dimer interface [polypeptide binding]; other site 645657010516 ATP binding site [chemical binding]; other site 645657010517 D-ribose pyranase; Provisional; Region: PRK11797 645657010518 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 645657010519 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 645657010520 Walker A/P-loop; other site 645657010521 ATP binding site [chemical binding]; other site 645657010522 Q-loop/lid; other site 645657010523 ABC transporter signature motif; other site 645657010524 Walker B; other site 645657010525 D-loop; other site 645657010526 H-loop/switch region; other site 645657010527 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 645657010528 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 645657010529 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 645657010530 TM-ABC transporter signature motif; other site 645657010531 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 645657010532 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 645657010533 ligand binding site [chemical binding]; other site 645657010534 dimerization interface [polypeptide binding]; other site 645657010535 Bacterial SH3 domain homologues; Region: SH3b; smart00287 645657010536 Bacterial SH3 domain; Region: SH3_3; cl17532 645657010537 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 645657010538 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 645657010539 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 645657010540 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 645657010541 acetolactate synthase; Reviewed; Region: PRK08617 645657010542 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 645657010543 PYR/PP interface [polypeptide binding]; other site 645657010544 dimer interface [polypeptide binding]; other site 645657010545 TPP binding site [chemical binding]; other site 645657010546 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 645657010547 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 645657010548 TPP-binding site [chemical binding]; other site 645657010549 dimer interface [polypeptide binding]; other site 645657010550 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 645657010551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657010552 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 645657010553 putative dimerization interface [polypeptide binding]; other site 645657010554 putative substrate binding pocket [chemical binding]; other site 645657010555 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 645657010556 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 645657010557 transmembrane helices; other site 645657010558 CotH protein; Region: CotH; pfam08757 645657010559 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 645657010560 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 645657010561 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 645657010562 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 645657010563 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 645657010564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657010565 putative DNA binding site [nucleotide binding]; other site 645657010566 putative Zn2+ binding site [ion binding]; other site 645657010567 AsnC family; Region: AsnC_trans_reg; pfam01037 645657010568 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 645657010569 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 645657010570 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 645657010571 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 645657010572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657010573 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657010574 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 645657010575 dimerization interface [polypeptide binding]; other site 645657010576 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 645657010577 Active_site [active] 645657010578 LXG domain of WXG superfamily; Region: LXG; pfam04740 645657010579 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 645657010580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 645657010581 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 645657010582 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 645657010583 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 645657010584 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 645657010585 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 645657010586 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 645657010587 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 645657010588 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 645657010589 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 645657010590 Chain length determinant protein; Region: Wzz; cl15801 645657010591 SWIM zinc finger; Region: SWIM; pfam04434 645657010592 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 645657010593 SNF2 Helicase protein; Region: DUF3670; pfam12419 645657010594 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645657010595 ATP binding site [chemical binding]; other site 645657010596 putative Mg++ binding site [ion binding]; other site 645657010597 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657010598 nucleotide binding region [chemical binding]; other site 645657010599 ATP-binding site [chemical binding]; other site 645657010600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657010601 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 645657010602 active site 645657010603 motif I; other site 645657010604 motif II; other site 645657010605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657010606 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 645657010607 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 645657010608 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 645657010609 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 645657010610 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 645657010611 dimer interface [polypeptide binding]; other site 645657010612 ssDNA binding site [nucleotide binding]; other site 645657010613 tetramer (dimer of dimers) interface [polypeptide binding]; other site 645657010614 YwpF-like protein; Region: YwpF; pfam14183 645657010615 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 645657010616 active site 645657010617 catalytic site [active] 645657010618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657010619 active site 645657010620 dimerization interface [polypeptide binding]; other site 645657010621 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 645657010622 Histidine kinase; Region: His_kinase; pfam06580 645657010623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657010624 ATP binding site [chemical binding]; other site 645657010625 Mg2+ binding site [ion binding]; other site 645657010626 G-X-G motif; other site 645657010627 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 645657010628 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 645657010629 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 645657010630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657010631 binding surface 645657010632 TPR motif; other site 645657010633 Tetratricopeptide repeat; Region: TPR_16; pfam13432 645657010634 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 645657010635 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 645657010636 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 645657010637 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 645657010638 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 645657010639 rod shape-determining protein Mbl; Provisional; Region: PRK13928 645657010640 MreB and similar proteins; Region: MreB_like; cd10225 645657010641 nucleotide binding site [chemical binding]; other site 645657010642 Mg binding site [ion binding]; other site 645657010643 putative protofilament interaction site [polypeptide binding]; other site 645657010644 RodZ interaction site [polypeptide binding]; other site 645657010645 Stage III sporulation protein D; Region: SpoIIID; pfam12116 645657010646 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657010647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657010648 putative Zn2+ binding site [ion binding]; other site 645657010649 putative DNA binding site [nucleotide binding]; other site 645657010650 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657010651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657010652 putative substrate translocation pore; other site 645657010653 Right handed beta helix region; Region: Beta_helix; pfam13229 645657010654 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 645657010655 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 645657010656 Na binding site [ion binding]; other site 645657010657 putative substrate binding site [chemical binding]; other site 645657010658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657010659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657010660 putative substrate translocation pore; other site 645657010661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657010662 Isochorismatase family; Region: Isochorismatase; pfam00857 645657010663 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 645657010664 catalytic triad [active] 645657010665 conserved cis-peptide bond; other site 645657010666 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 645657010667 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 645657010668 Nitrogen regulatory protein P-II; Region: P-II; smart00938 645657010669 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 645657010670 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 645657010671 active site 645657010672 VanZ like family; Region: VanZ; pfam04892 645657010673 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 645657010674 Peptidase family M23; Region: Peptidase_M23; pfam01551 645657010675 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 645657010676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657010677 Coenzyme A binding pocket [chemical binding]; other site 645657010678 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 645657010679 NeuB family; Region: NeuB; pfam03102 645657010680 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 645657010681 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 645657010682 ligand binding site; other site 645657010683 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 645657010684 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 645657010685 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 645657010686 putative active site [active] 645657010687 catalytic site [active] 645657010688 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 645657010689 putative active site [active] 645657010690 catalytic site [active] 645657010691 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 645657010692 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 645657010693 DNA binding residues [nucleotide binding] 645657010694 dimer interface [polypeptide binding]; other site 645657010695 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 645657010696 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 645657010697 NADH(P)-binding; Region: NAD_binding_10; pfam13460 645657010698 NAD binding site [chemical binding]; other site 645657010699 substrate binding site [chemical binding]; other site 645657010700 putative active site [active] 645657010701 Predicted transcriptional regulator [Transcription]; Region: COG1959 645657010702 Transcriptional regulator; Region: Rrf2; pfam02082 645657010703 urease subunit alpha; Reviewed; Region: ureC; PRK13207 645657010704 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 645657010705 subunit interactions [polypeptide binding]; other site 645657010706 active site 645657010707 flap region; other site 645657010708 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 645657010709 gamma-beta subunit interface [polypeptide binding]; other site 645657010710 alpha-beta subunit interface [polypeptide binding]; other site 645657010711 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 645657010712 alpha-gamma subunit interface [polypeptide binding]; other site 645657010713 beta-gamma subunit interface [polypeptide binding]; other site 645657010714 CsbD-like; Region: CsbD; pfam05532 645657010715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657010716 binding surface 645657010717 TPR motif; other site 645657010718 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657010719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657010720 binding surface 645657010721 TPR motif; other site 645657010722 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 645657010723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645657010724 FeS/SAM binding site; other site 645657010725 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 645657010726 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 645657010727 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 645657010728 metal ion-dependent adhesion site (MIDAS); other site 645657010729 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 645657010730 metal ion-dependent adhesion site (MIDAS); other site 645657010731 stage II sporulation protein D; Region: spore_II_D; TIGR02870 645657010732 Stage II sporulation protein; Region: SpoIID; pfam08486 645657010733 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 645657010734 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 645657010735 hinge; other site 645657010736 active site 645657010737 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 645657010738 Predicted membrane protein [Function unknown]; Region: COG4836 645657010739 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 645657010740 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 645657010741 gamma subunit interface [polypeptide binding]; other site 645657010742 epsilon subunit interface [polypeptide binding]; other site 645657010743 LBP interface [polypeptide binding]; other site 645657010744 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 645657010745 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 645657010746 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 645657010747 alpha subunit interaction interface [polypeptide binding]; other site 645657010748 Walker A motif; other site 645657010749 ATP binding site [chemical binding]; other site 645657010750 Walker B motif; other site 645657010751 inhibitor binding site; inhibition site 645657010752 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 645657010753 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 645657010754 core domain interface [polypeptide binding]; other site 645657010755 delta subunit interface [polypeptide binding]; other site 645657010756 epsilon subunit interface [polypeptide binding]; other site 645657010757 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 645657010758 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 645657010759 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 645657010760 beta subunit interaction interface [polypeptide binding]; other site 645657010761 Walker A motif; other site 645657010762 ATP binding site [chemical binding]; other site 645657010763 Walker B motif; other site 645657010764 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 645657010765 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 645657010766 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 645657010767 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 645657010768 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 645657010769 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 645657010770 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 645657010771 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 645657010772 ATP synthase I chain; Region: ATP_synt_I; pfam03899 645657010773 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645657010774 active site 645657010775 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 645657010776 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 645657010777 dimer interface [polypeptide binding]; other site 645657010778 active site 645657010779 glycine-pyridoxal phosphate binding site [chemical binding]; other site 645657010780 folate binding site [chemical binding]; other site 645657010781 hypothetical protein; Provisional; Region: PRK13690 645657010782 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 645657010783 Low molecular weight phosphatase family; Region: LMWPc; cd00115 645657010784 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 645657010785 active site 645657010786 Predicted membrane protein [Function unknown]; Region: COG1971 645657010787 Domain of unknown function DUF; Region: DUF204; pfam02659 645657010788 Domain of unknown function DUF; Region: DUF204; pfam02659 645657010789 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 645657010790 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 645657010791 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645657010792 stage II sporulation protein R; Region: spore_II_R; TIGR02837 645657010793 HemK family putative methylases; Region: hemK_fam; TIGR00536 645657010794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657010795 S-adenosylmethionine binding site [chemical binding]; other site 645657010796 peptide chain release factor 1; Validated; Region: prfA; PRK00591 645657010797 This domain is found in peptide chain release factors; Region: PCRF; smart00937 645657010798 RF-1 domain; Region: RF-1; pfam00472 645657010799 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 645657010800 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657010801 putative metal binding site [ion binding]; other site 645657010802 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 645657010803 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 645657010804 DNA binding residues [nucleotide binding] 645657010805 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 645657010806 malate dehydrogenase; Provisional; Region: PRK13529 645657010807 Malic enzyme, N-terminal domain; Region: malic; pfam00390 645657010808 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 645657010809 NAD(P) binding site [chemical binding]; other site 645657010810 thymidine kinase; Provisional; Region: PRK04296 645657010811 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 645657010812 transcription termination factor Rho; Provisional; Region: rho; PRK09376 645657010813 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 645657010814 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 645657010815 RNA binding site [nucleotide binding]; other site 645657010816 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 645657010817 multimer interface [polypeptide binding]; other site 645657010818 Walker A motif; other site 645657010819 ATP binding site [chemical binding]; other site 645657010820 Walker B motif; other site 645657010821 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 645657010822 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 645657010823 putative active site [active] 645657010824 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 645657010825 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 645657010826 hinge; other site 645657010827 active site 645657010828 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 645657010829 active site 645657010830 intersubunit interactions; other site 645657010831 catalytic residue [active] 645657010832 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 645657010833 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 645657010834 intersubunit interface [polypeptide binding]; other site 645657010835 active site 645657010836 zinc binding site [ion binding]; other site 645657010837 Na+ binding site [ion binding]; other site 645657010838 Response regulator receiver domain; Region: Response_reg; pfam00072 645657010839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657010840 active site 645657010841 phosphorylation site [posttranslational modification] 645657010842 intermolecular recognition site; other site 645657010843 dimerization interface [polypeptide binding]; other site 645657010844 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 645657010845 CTP synthetase; Validated; Region: pyrG; PRK05380 645657010846 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 645657010847 Catalytic site [active] 645657010848 active site 645657010849 UTP binding site [chemical binding]; other site 645657010850 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 645657010851 active site 645657010852 putative oxyanion hole; other site 645657010853 catalytic triad [active] 645657010854 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 645657010855 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 645657010856 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 645657010857 FAD binding site [chemical binding]; other site 645657010858 homotetramer interface [polypeptide binding]; other site 645657010859 substrate binding pocket [chemical binding]; other site 645657010860 catalytic base [active] 645657010861 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 645657010862 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 645657010863 Cysteine-rich domain; Region: CCG; pfam02754 645657010864 Cysteine-rich domain; Region: CCG; pfam02754 645657010865 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 645657010866 putative active site [active] 645657010867 catalytic site [active] 645657010868 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 645657010869 PLD-like domain; Region: PLDc_2; pfam13091 645657010870 putative active site [active] 645657010871 catalytic site [active] 645657010872 UV-endonuclease UvdE; Region: UvdE; cl10036 645657010873 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 645657010874 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 645657010875 folate binding site [chemical binding]; other site 645657010876 NADP+ binding site [chemical binding]; other site 645657010877 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645657010878 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 645657010879 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 645657010880 Walker A/P-loop; other site 645657010881 ATP binding site [chemical binding]; other site 645657010882 Q-loop/lid; other site 645657010883 ABC transporter signature motif; other site 645657010884 Walker B; other site 645657010885 D-loop; other site 645657010886 H-loop/switch region; other site 645657010887 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 645657010888 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 645657010889 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 645657010890 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 645657010891 putative active site [active] 645657010892 catalytic site [active] 645657010893 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 645657010894 putative active site [active] 645657010895 catalytic site [active] 645657010896 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 645657010897 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 645657010898 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 645657010899 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 645657010900 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 645657010901 [4Fe-4S] binding site [ion binding]; other site 645657010902 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 645657010903 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 645657010904 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 645657010905 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 645657010906 molybdopterin cofactor binding site; other site 645657010907 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 645657010908 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 645657010909 ligand binding site [chemical binding]; other site 645657010910 flexible hinge region; other site 645657010911 YwiC-like protein; Region: YwiC; pfam14256 645657010912 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 645657010913 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 645657010914 ligand binding site [chemical binding]; other site 645657010915 flexible hinge region; other site 645657010916 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 645657010917 putative switch regulator; other site 645657010918 non-specific DNA interactions [nucleotide binding]; other site 645657010919 DNA binding site [nucleotide binding] 645657010920 sequence specific DNA binding site [nucleotide binding]; other site 645657010921 putative cAMP binding site [chemical binding]; other site 645657010922 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 645657010923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657010924 putative substrate translocation pore; other site 645657010925 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 645657010926 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 645657010927 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 645657010928 active site 645657010929 HIGH motif; other site 645657010930 KMSK motif region; other site 645657010931 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 645657010932 tRNA binding surface [nucleotide binding]; other site 645657010933 anticodon binding site; other site 645657010934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 645657010935 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 645657010936 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 645657010937 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 645657010938 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645657010939 FeS/SAM binding site; other site 645657010940 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 645657010941 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 645657010942 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645657010943 Walker A/P-loop; other site 645657010944 ATP binding site [chemical binding]; other site 645657010945 Q-loop/lid; other site 645657010946 ABC transporter signature motif; other site 645657010947 Walker B; other site 645657010948 D-loop; other site 645657010949 H-loop/switch region; other site 645657010950 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 645657010951 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 645657010952 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 645657010953 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 645657010954 Uncharacterized conserved protein [Function unknown]; Region: COG3391 645657010955 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 645657010956 Uncharacterized conserved protein [Function unknown]; Region: COG3391 645657010957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 645657010958 binding surface 645657010959 TPR motif; other site 645657010960 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 645657010961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657010962 TPR motif; other site 645657010963 binding surface 645657010964 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657010965 agmatinase; Region: agmatinase; TIGR01230 645657010966 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 645657010967 putative active site [active] 645657010968 Mn binding site [ion binding]; other site 645657010969 spermidine synthase; Provisional; Region: PRK00811 645657010970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657010971 Transglycosylase; Region: Transgly; pfam00912 645657010972 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 645657010973 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 645657010974 YwhD family; Region: YwhD; pfam08741 645657010975 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 645657010976 Peptidase family M50; Region: Peptidase_M50; pfam02163 645657010977 active site 645657010978 putative substrate binding region [chemical binding]; other site 645657010979 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 645657010980 active site 1 [active] 645657010981 dimer interface [polypeptide binding]; other site 645657010982 hexamer interface [polypeptide binding]; other site 645657010983 active site 2 [active] 645657010984 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657010985 MarR family; Region: MarR; pfam01047 645657010986 MarR family; Region: MarR_2; cl17246 645657010987 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 645657010988 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 645657010989 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 645657010990 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 645657010991 active site 645657010992 dimer interface [polypeptide binding]; other site 645657010993 motif 1; other site 645657010994 motif 2; other site 645657010995 motif 3; other site 645657010996 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 645657010997 anticodon binding site; other site 645657010998 benzoate transport; Region: 2A0115; TIGR00895 645657010999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657011000 putative substrate translocation pore; other site 645657011001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657011002 Rrf2 family protein; Region: rrf2_super; TIGR00738 645657011003 Transcriptional regulator; Region: Rrf2; pfam02082 645657011004 Uncharacterized conserved protein [Function unknown]; Region: COG3465 645657011005 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 645657011006 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645657011007 Zn2+ binding site [ion binding]; other site 645657011008 Mg2+ binding site [ion binding]; other site 645657011009 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 645657011010 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 645657011011 EamA-like transporter family; Region: EamA; pfam00892 645657011012 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 645657011013 EamA-like transporter family; Region: EamA; pfam00892 645657011014 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 645657011015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657011016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657011017 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 645657011018 putative dimerization interface [polypeptide binding]; other site 645657011019 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 645657011020 putative heme peroxidase; Provisional; Region: PRK12276 645657011021 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 645657011022 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 645657011023 putative NAD(P) binding site [chemical binding]; other site 645657011024 putative active site [active] 645657011025 transaminase; Reviewed; Region: PRK08068 645657011026 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645657011027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657011028 homodimer interface [polypeptide binding]; other site 645657011029 catalytic residue [active] 645657011030 H+ Antiporter protein; Region: 2A0121; TIGR00900 645657011031 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 645657011032 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 645657011033 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 645657011034 classical (c) SDRs; Region: SDR_c; cd05233 645657011035 NAD(P) binding site [chemical binding]; other site 645657011036 active site 645657011037 Cupin domain; Region: Cupin_2; pfam07883 645657011038 Cupin domain; Region: Cupin_2; pfam07883 645657011039 Prephenate dehydratase; Region: PDT; pfam00800 645657011040 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 645657011041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657011042 putative substrate translocation pore; other site 645657011043 S-methylmethionine transporter; Provisional; Region: PRK11387 645657011044 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 645657011045 putative metal binding site [ion binding]; other site 645657011046 putative dimer interface [polypeptide binding]; other site 645657011047 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 645657011048 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 645657011049 Glutamate binding site [chemical binding]; other site 645657011050 homodimer interface [polypeptide binding]; other site 645657011051 NAD binding site [chemical binding]; other site 645657011052 catalytic residues [active] 645657011053 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 645657011054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 645657011055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 645657011056 NAD(P) binding site [chemical binding]; other site 645657011057 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 645657011058 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 645657011059 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 645657011060 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 645657011061 NADP binding site [chemical binding]; other site 645657011062 active site 645657011063 putative substrate binding site [chemical binding]; other site 645657011064 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 645657011065 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 645657011066 NAD binding site [chemical binding]; other site 645657011067 substrate binding site [chemical binding]; other site 645657011068 homodimer interface [polypeptide binding]; other site 645657011069 active site 645657011070 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 645657011071 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 645657011072 substrate binding site; other site 645657011073 tetramer interface; other site 645657011074 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 645657011075 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 645657011076 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 645657011077 ligand binding site; other site 645657011078 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 645657011079 NeuB family; Region: NeuB; pfam03102 645657011080 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 645657011081 NeuB binding interface [polypeptide binding]; other site 645657011082 putative substrate binding site [chemical binding]; other site 645657011083 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 645657011084 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 645657011085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657011086 Coenzyme A binding pocket [chemical binding]; other site 645657011087 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 645657011088 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 645657011089 inhibitor-cofactor binding pocket; inhibition site 645657011090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657011091 catalytic residue [active] 645657011092 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 645657011093 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 645657011094 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 645657011095 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 645657011096 active site 645657011097 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 645657011098 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 645657011099 Permease family; Region: Xan_ur_permease; pfam00860 645657011100 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 645657011101 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 645657011102 NAD(P) binding site [chemical binding]; other site 645657011103 catalytic residues [active] 645657011104 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 645657011105 ligand binding site [chemical binding]; other site 645657011106 active site 645657011107 UGI interface [polypeptide binding]; other site 645657011108 catalytic site [active] 645657011109 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 645657011110 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 645657011111 active site 645657011112 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 645657011113 dimer interface [polypeptide binding]; other site 645657011114 substrate binding site [chemical binding]; other site 645657011115 ATP binding site [chemical binding]; other site 645657011116 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 645657011117 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 645657011118 substrate binding [chemical binding]; other site 645657011119 active site 645657011120 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 645657011121 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 645657011122 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645657011123 active site turn [active] 645657011124 phosphorylation site [posttranslational modification] 645657011125 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645657011126 formate/nitrite transporter; Region: fnt; TIGR00790 645657011127 PRD domain; Region: PRD; pfam00874 645657011128 PRD domain; Region: PRD; pfam00874 645657011129 CAT RNA binding domain; Region: CAT_RBD; smart01061 645657011130 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 645657011131 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 645657011132 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 645657011133 putative active site [active] 645657011134 catalytic triad [active] 645657011135 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 645657011136 PA/protease domain interface [polypeptide binding]; other site 645657011137 putative integrin binding motif; other site 645657011138 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 645657011139 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 645657011140 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 645657011141 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 645657011142 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 645657011143 dimer interface [polypeptide binding]; other site 645657011144 FMN binding site [chemical binding]; other site 645657011145 NADPH bind site [chemical binding]; other site 645657011146 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 645657011147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 645657011148 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 645657011149 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 645657011150 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 645657011151 Subunit I/III interface [polypeptide binding]; other site 645657011152 Subunit III/IV interface [polypeptide binding]; other site 645657011153 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 645657011154 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 645657011155 D-pathway; other site 645657011156 Putative ubiquinol binding site [chemical binding]; other site 645657011157 Low-spin heme (heme b) binding site [chemical binding]; other site 645657011158 Putative water exit pathway; other site 645657011159 Binuclear center (heme o3/CuB) [ion binding]; other site 645657011160 K-pathway; other site 645657011161 Putative proton exit pathway; other site 645657011162 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 645657011163 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 645657011164 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 645657011165 Predicted membrane protein [Function unknown]; Region: COG2261 645657011166 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 645657011167 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 645657011168 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 645657011169 galactokinase; Provisional; Region: PRK05322 645657011170 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 645657011171 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 645657011172 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 645657011173 Predicted membrane protein [Function unknown]; Region: COG2246 645657011174 GtrA-like protein; Region: GtrA; pfam04138 645657011175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657011176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657011177 Anti-repressor SinI; Region: SinI; pfam08671 645657011178 Predicted membrane protein [Function unknown]; Region: COG3162 645657011179 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 645657011180 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 645657011181 Na binding site [ion binding]; other site 645657011182 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 645657011183 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 645657011184 catalytic residues [active] 645657011185 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 645657011186 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 645657011187 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 645657011188 Imelysin; Region: Peptidase_M75; pfam09375 645657011189 FTR1 family protein; Region: TIGR00145 645657011190 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 645657011191 thiamine phosphate binding site [chemical binding]; other site 645657011192 active site 645657011193 pyrophosphate binding site [ion binding]; other site 645657011194 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 645657011195 substrate binding site [chemical binding]; other site 645657011196 multimerization interface [polypeptide binding]; other site 645657011197 ATP binding site [chemical binding]; other site 645657011198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645657011199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645657011200 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 645657011201 putative dimerization interface [polypeptide binding]; other site 645657011202 holin-like protein; Validated; Region: PRK01658 645657011203 TIGR00659 family protein; Region: TIGR00659 645657011204 sugar efflux transporter; Region: 2A0120; TIGR00899 645657011205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657011206 putative substrate translocation pore; other site 645657011207 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 645657011208 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 645657011209 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 645657011210 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 645657011211 putative RNA binding site [nucleotide binding]; other site 645657011212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657011213 S-adenosylmethionine binding site [chemical binding]; other site 645657011214 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657011215 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 645657011216 active site 645657011217 metal binding site [ion binding]; metal-binding site 645657011218 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 645657011219 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 645657011220 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 645657011221 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 645657011222 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 645657011223 active site 645657011224 catalytic residues [active] 645657011225 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 645657011226 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645657011227 active site turn [active] 645657011228 phosphorylation site [posttranslational modification] 645657011229 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645657011230 transcriptional antiterminator BglG; Provisional; Region: PRK09772 645657011231 CAT RNA binding domain; Region: CAT_RBD; pfam03123 645657011232 PRD domain; Region: PRD; pfam00874 645657011233 PRD domain; Region: PRD; pfam00874 645657011234 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 645657011235 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 645657011236 Ligand binding site; other site 645657011237 metal-binding site 645657011238 Predicted integral membrane protein [Function unknown]; Region: COG5522 645657011239 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657011240 MarR family; Region: MarR; pfam01047 645657011241 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 645657011242 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 645657011243 active site 645657011244 HIGH motif; other site 645657011245 dimer interface [polypeptide binding]; other site 645657011246 KMSKS motif; other site 645657011247 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645657011248 RNA binding surface [nucleotide binding]; other site 645657011249 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 645657011250 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 645657011251 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 645657011252 PA/protease domain interface [polypeptide binding]; other site 645657011253 putative integrin binding motif; other site 645657011254 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 645657011255 metal binding site [ion binding]; metal-binding site 645657011256 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 645657011257 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 645657011258 synthetase active site [active] 645657011259 NTP binding site [chemical binding]; other site 645657011260 metal binding site [ion binding]; metal-binding site 645657011261 Transposase; Region: HTH_Tnp_1; pfam01527 645657011262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 645657011263 putative transposase OrfB; Reviewed; Region: PHA02517 645657011264 HTH-like domain; Region: HTH_21; pfam13276 645657011265 Integrase core domain; Region: rve; pfam00665 645657011266 Integrase core domain; Region: rve_2; pfam13333 645657011267 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 645657011268 UbiA prenyltransferase family; Region: UbiA; pfam01040 645657011269 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 645657011270 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 645657011271 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 645657011272 acyl-activating enzyme (AAE) consensus motif; other site 645657011273 AMP binding site [chemical binding]; other site 645657011274 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 645657011275 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 645657011276 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 645657011277 DltD N-terminal region; Region: DltD_N; pfam04915 645657011278 DltD central region; Region: DltD_M; pfam04918 645657011279 DltD C-terminal region; Region: DltD_C; pfam04914 645657011280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645657011281 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 645657011282 NAD(P) binding site [chemical binding]; other site 645657011283 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 645657011284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645657011285 active site 645657011286 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 645657011287 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 645657011288 homodimer interface [polypeptide binding]; other site 645657011289 substrate-cofactor binding pocket; other site 645657011290 catalytic residue [active] 645657011291 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 645657011292 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 645657011293 NAD binding site [chemical binding]; other site 645657011294 sugar binding site [chemical binding]; other site 645657011295 divalent metal binding site [ion binding]; other site 645657011296 tetramer (dimer of dimers) interface [polypeptide binding]; other site 645657011297 dimer interface [polypeptide binding]; other site 645657011298 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 645657011299 methionine cluster; other site 645657011300 active site 645657011301 phosphorylation site [posttranslational modification] 645657011302 metal binding site [ion binding]; metal-binding site 645657011303 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 645657011304 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 645657011305 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 645657011306 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645657011307 HTH domain; Region: HTH_11; pfam08279 645657011308 Mga helix-turn-helix domain; Region: Mga; pfam05043 645657011309 PRD domain; Region: PRD; pfam00874 645657011310 PRD domain; Region: PRD; pfam00874 645657011311 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645657011312 active site 645657011313 P-loop; other site 645657011314 phosphorylation site [posttranslational modification] 645657011315 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645657011316 active site 645657011317 phosphorylation site [posttranslational modification] 645657011318 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 645657011319 active site 645657011320 DNA binding site [nucleotide binding] 645657011321 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 645657011322 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 645657011323 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 645657011324 heme binding pocket [chemical binding]; other site 645657011325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657011326 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657011327 putative substrate translocation pore; other site 645657011328 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 645657011329 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645657011330 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645657011331 Walker A/P-loop; other site 645657011332 ATP binding site [chemical binding]; other site 645657011333 Q-loop/lid; other site 645657011334 ABC transporter signature motif; other site 645657011335 Walker B; other site 645657011336 D-loop; other site 645657011337 H-loop/switch region; other site 645657011338 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 645657011339 Exoribonuclease II [Transcription]; Region: Rnb; COG4776 645657011340 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 645657011341 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645657011342 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657011343 DNA binding residues [nucleotide binding] 645657011344 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 645657011345 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 645657011346 Na binding site [ion binding]; other site 645657011347 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 645657011348 putative substrate binding site [chemical binding]; other site 645657011349 putative ATP binding site [chemical binding]; other site 645657011350 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 645657011351 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645657011352 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 645657011353 Walker A/P-loop; other site 645657011354 ATP binding site [chemical binding]; other site 645657011355 Q-loop/lid; other site 645657011356 ABC transporter signature motif; other site 645657011357 Walker B; other site 645657011358 D-loop; other site 645657011359 H-loop/switch region; other site 645657011360 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 645657011361 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645657011362 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 645657011363 Walker A/P-loop; other site 645657011364 ATP binding site [chemical binding]; other site 645657011365 Q-loop/lid; other site 645657011366 ABC transporter signature motif; other site 645657011367 Walker B; other site 645657011368 D-loop; other site 645657011369 H-loop/switch region; other site 645657011370 cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203 645657011371 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 645657011372 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 645657011373 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 645657011374 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 645657011375 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 645657011376 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 645657011377 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 645657011378 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 645657011379 putative active site [active] 645657011380 putative metal binding site [ion binding]; other site 645657011381 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 645657011382 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 645657011383 Walker A/P-loop; other site 645657011384 ATP binding site [chemical binding]; other site 645657011385 Q-loop/lid; other site 645657011386 ABC transporter signature motif; other site 645657011387 Walker B; other site 645657011388 D-loop; other site 645657011389 H-loop/switch region; other site 645657011390 TOBE domain; Region: TOBE; pfam03459 645657011391 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 645657011392 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 645657011393 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 645657011394 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 645657011395 NAD(P) binding site [chemical binding]; other site 645657011396 catalytic residues [active] 645657011397 Uncharacterized conserved protein [Function unknown]; Region: COG1284 645657011398 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645657011399 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645657011400 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 645657011401 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 645657011402 UDP-glucose 4-epimerase; Region: PLN02240 645657011403 NAD binding site [chemical binding]; other site 645657011404 homodimer interface [polypeptide binding]; other site 645657011405 active site 645657011406 substrate binding site [chemical binding]; other site 645657011407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 645657011408 Histidine kinase; Region: HisKA_3; pfam07730 645657011409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657011410 ATP binding site [chemical binding]; other site 645657011411 Mg2+ binding site [ion binding]; other site 645657011412 G-X-G motif; other site 645657011413 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645657011414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657011415 active site 645657011416 phosphorylation site [posttranslational modification] 645657011417 intermolecular recognition site; other site 645657011418 dimerization interface [polypeptide binding]; other site 645657011419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645657011420 DNA binding residues [nucleotide binding] 645657011421 dimerization interface [polypeptide binding]; other site 645657011422 peptidase T; Region: peptidase-T; TIGR01882 645657011423 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 645657011424 metal binding site [ion binding]; metal-binding site 645657011425 dimer interface [polypeptide binding]; other site 645657011426 Tubby C 2; Region: Tub_2; cl02043 645657011427 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 645657011428 substrate binding site [chemical binding]; other site 645657011429 THF binding site; other site 645657011430 zinc-binding site [ion binding]; other site 645657011431 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 645657011432 substrate binding site [chemical binding]; other site 645657011433 THF binding site; other site 645657011434 zinc-binding site [ion binding]; other site 645657011435 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 645657011436 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 645657011437 NAD binding site [chemical binding]; other site 645657011438 homotetramer interface [polypeptide binding]; other site 645657011439 homodimer interface [polypeptide binding]; other site 645657011440 substrate binding site [chemical binding]; other site 645657011441 active site 645657011442 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 645657011443 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 645657011444 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 645657011445 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 645657011446 Methyltransferase domain; Region: Methyltransf_11; pfam08241 645657011447 S-adenosylmethionine binding site [chemical binding]; other site 645657011448 nucleoside transporter; Region: nupC; TIGR00804 645657011449 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 645657011450 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 645657011451 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 645657011452 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 645657011453 hydroperoxidase II; Provisional; Region: katE; PRK11249 645657011454 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 645657011455 tetramer interface [polypeptide binding]; other site 645657011456 heme binding pocket [chemical binding]; other site 645657011457 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 645657011458 domain interactions; other site 645657011459 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 645657011460 Citrate transporter; Region: CitMHS; pfam03600 645657011461 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 645657011462 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 645657011463 active site 645657011464 active site 645657011465 catalytic residues [active] 645657011466 transcriptional antiterminator BglG; Provisional; Region: PRK09772 645657011467 CAT RNA binding domain; Region: CAT_RBD; pfam03123 645657011468 PRD domain; Region: PRD; pfam00874 645657011469 PRD domain; Region: PRD; pfam00874 645657011470 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 645657011471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657011472 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 645657011473 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 645657011474 ATP binding site [chemical binding]; other site 645657011475 Mg++ binding site [ion binding]; other site 645657011476 motif III; other site 645657011477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657011478 nucleotide binding region [chemical binding]; other site 645657011479 ATP-binding site [chemical binding]; other site 645657011480 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 645657011481 RNA binding site [nucleotide binding]; other site 645657011482 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 645657011483 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 645657011484 active site 645657011485 catalytic triad [active] 645657011486 YxiJ-like protein; Region: YxiJ; pfam14176 645657011487 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 645657011488 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 645657011489 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645657011490 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 645657011491 RHS Repeat; Region: RHS_repeat; cl11982 645657011492 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 645657011493 YxiJ-like protein; Region: YxiJ; pfam14176 645657011494 RHS Repeat; Region: RHS_repeat; pfam05593 645657011495 RHS Repeat; Region: RHS_repeat; pfam05593 645657011496 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 645657011497 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 645657011498 RHS Repeat; Region: RHS_repeat; pfam05593 645657011499 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 645657011500 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 645657011501 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 645657011502 EamA-like transporter family; Region: EamA; pfam00892 645657011503 EamA-like transporter family; Region: EamA; pfam00892 645657011504 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 645657011505 classical (c) SDRs; Region: SDR_c; cd05233 645657011506 NAD(P) binding site [chemical binding]; other site 645657011507 active site 645657011508 Biofilm formation and stress response factor; Region: BsmA; pfam10014 645657011509 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 645657011510 Ligand Binding Site [chemical binding]; other site 645657011511 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 645657011512 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 645657011513 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 645657011514 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645657011515 active site turn [active] 645657011516 phosphorylation site [posttranslational modification] 645657011517 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645657011518 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 645657011519 HPr interaction site; other site 645657011520 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645657011521 active site 645657011522 phosphorylation site [posttranslational modification] 645657011523 Uncharacterized conserved protein [Function unknown]; Region: COG5444 645657011524 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 645657011525 LXG domain of WXG superfamily; Region: LXG; pfam04740 645657011526 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180 645657011527 PLD-like domain; Region: PLDc_2; pfam13091 645657011528 putative homodimer interface [polypeptide binding]; other site 645657011529 putative active site [active] 645657011530 catalytic site [active] 645657011531 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 645657011532 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645657011533 ATP binding site [chemical binding]; other site 645657011534 putative Mg++ binding site [ion binding]; other site 645657011535 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645657011536 nucleotide binding region [chemical binding]; other site 645657011537 ATP-binding site [chemical binding]; other site 645657011538 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 645657011539 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 645657011540 active site 645657011541 8-oxo-dGMP binding site [chemical binding]; other site 645657011542 nudix motif; other site 645657011543 metal binding site [ion binding]; metal-binding site 645657011544 AAA domain; Region: AAA_11; pfam13086 645657011545 Part of AAA domain; Region: AAA_19; pfam13245 645657011546 Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443 645657011547 AAA domain; Region: AAA_12; pfam13087 645657011548 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 645657011549 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 645657011550 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 645657011551 substrate binding site [chemical binding]; other site 645657011552 active site 645657011553 urocanate hydratase; Provisional; Region: PRK05414 645657011554 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 645657011555 S-methylmethionine transporter; Provisional; Region: PRK11387 645657011556 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 645657011557 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 645657011558 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 645657011559 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 645657011560 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 645657011561 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 645657011562 Nucleoside recognition; Region: Gate; pfam07670 645657011563 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 645657011564 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 645657011565 intersubunit interface [polypeptide binding]; other site 645657011566 active site 645657011567 catalytic residue [active] 645657011568 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 645657011569 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645657011570 DNA binding residues [nucleotide binding] 645657011571 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 645657011572 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 645657011573 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 645657011574 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 645657011575 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 645657011576 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 645657011577 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645657011578 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 645657011579 metal binding site [ion binding]; metal-binding site 645657011580 dimer interface [polypeptide binding]; other site 645657011581 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 645657011582 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 645657011583 Walker A/P-loop; other site 645657011584 ATP binding site [chemical binding]; other site 645657011585 Q-loop/lid; other site 645657011586 ABC transporter signature motif; other site 645657011587 Walker B; other site 645657011588 D-loop; other site 645657011589 H-loop/switch region; other site 645657011590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645657011591 dimer interface [polypeptide binding]; other site 645657011592 conserved gate region; other site 645657011593 putative PBP binding loops; other site 645657011594 ABC-ATPase subunit interface; other site 645657011595 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645657011596 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645657011597 substrate binding pocket [chemical binding]; other site 645657011598 membrane-bound complex binding site; other site 645657011599 hinge residues; other site 645657011600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657011601 Coenzyme A binding pocket [chemical binding]; other site 645657011602 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 645657011603 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 645657011604 active site 645657011605 non-prolyl cis peptide bond; other site 645657011606 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 645657011607 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 645657011608 active site 645657011609 sugar phosphate phosphatase; Provisional; Region: PRK10513 645657011610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657011611 active site 645657011612 motif I; other site 645657011613 motif II; other site 645657011614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645657011615 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 645657011616 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 645657011617 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 645657011618 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 645657011619 putative ligand binding residues [chemical binding]; other site 645657011620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 645657011621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657011622 ABC transporter signature motif; other site 645657011623 Walker B; other site 645657011624 D-loop; other site 645657011625 H-loop/switch region; other site 645657011626 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645657011627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657011628 Walker A/P-loop; other site 645657011629 ATP binding site [chemical binding]; other site 645657011630 Q-loop/lid; other site 645657011631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645657011632 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 645657011633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657011634 ATP binding site [chemical binding]; other site 645657011635 Mg2+ binding site [ion binding]; other site 645657011636 G-X-G motif; other site 645657011637 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645657011638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657011639 active site 645657011640 phosphorylation site [posttranslational modification] 645657011641 intermolecular recognition site; other site 645657011642 dimerization interface [polypeptide binding]; other site 645657011643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645657011644 DNA binding site [nucleotide binding] 645657011645 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 645657011646 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 645657011647 intersubunit interface [polypeptide binding]; other site 645657011648 active site 645657011649 zinc binding site [ion binding]; other site 645657011650 Na+ binding site [ion binding]; other site 645657011651 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 645657011652 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 645657011653 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 645657011654 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 645657011655 DNA interaction; other site 645657011656 Metal-binding active site; metal-binding site 645657011657 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 645657011658 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 645657011659 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 645657011660 Glucuronate isomerase; Region: UxaC; cl00829 645657011661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657011662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645657011663 putative substrate translocation pore; other site 645657011664 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 645657011665 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 645657011666 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 645657011667 PYR/PP interface [polypeptide binding]; other site 645657011668 dimer interface [polypeptide binding]; other site 645657011669 TPP binding site [chemical binding]; other site 645657011670 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 645657011671 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 645657011672 TPP-binding site; other site 645657011673 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 645657011674 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 645657011675 substrate binding site [chemical binding]; other site 645657011676 ATP binding site [chemical binding]; other site 645657011677 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 645657011678 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 645657011679 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 645657011680 tetrameric interface [polypeptide binding]; other site 645657011681 NAD binding site [chemical binding]; other site 645657011682 catalytic residues [active] 645657011683 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 645657011684 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 645657011685 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 645657011686 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 645657011687 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 645657011688 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 645657011689 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645657011690 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645657011691 active site 645657011692 catalytic tetrad [active] 645657011693 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 645657011694 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 645657011695 CGNR zinc finger; Region: zf-CGNR; pfam11706 645657011696 HPP family; Region: HPP; pfam04982 645657011697 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 645657011698 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 645657011699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657011700 heat shock protein 90; Provisional; Region: PRK05218 645657011701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657011702 ATP binding site [chemical binding]; other site 645657011703 Mg2+ binding site [ion binding]; other site 645657011704 G-X-G motif; other site 645657011705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645657011706 classical (c) SDRs; Region: SDR_c; cd05233 645657011707 NAD(P) binding site [chemical binding]; other site 645657011708 active site 645657011709 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 645657011710 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 645657011711 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 645657011712 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 645657011713 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 645657011714 putative active site [active] 645657011715 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645657011716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657011717 Walker A/P-loop; other site 645657011718 ATP binding site [chemical binding]; other site 645657011719 Q-loop/lid; other site 645657011720 ABC transporter signature motif; other site 645657011721 Walker B; other site 645657011722 D-loop; other site 645657011723 H-loop/switch region; other site 645657011724 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 645657011725 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 645657011726 HlyD family secretion protein; Region: HlyD_3; pfam13437 645657011727 Cupin domain; Region: Cupin_2; pfam07883 645657011728 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 645657011729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645657011730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645657011731 short chain dehydrogenase; Provisional; Region: PRK07109 645657011732 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 645657011733 putative NAD(P) binding site [chemical binding]; other site 645657011734 active site 645657011735 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657011736 MarR family; Region: MarR; pfam01047 645657011737 LrgA family; Region: LrgA; cl00608 645657011738 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 645657011739 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 645657011740 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 645657011741 Glycerate kinase family; Region: Gly_kinase; pfam02595 645657011742 Transcriptional regulators [Transcription]; Region: GntR; COG1802 645657011743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657011744 DNA-binding site [nucleotide binding]; DNA binding site 645657011745 FCD domain; Region: FCD; pfam07729 645657011746 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 645657011747 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 645657011748 N- and C-terminal domain interface [polypeptide binding]; other site 645657011749 active site 645657011750 catalytic site [active] 645657011751 metal binding site [ion binding]; metal-binding site 645657011752 carbohydrate binding site [chemical binding]; other site 645657011753 ATP binding site [chemical binding]; other site 645657011754 fructuronate transporter; Provisional; Region: PRK10034; cl15264 645657011755 gluconate transporter; Region: gntP; TIGR00791 645657011756 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 645657011757 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 645657011758 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 645657011759 peroxiredoxin; Region: AhpC; TIGR03137 645657011760 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 645657011761 dimer interface [polypeptide binding]; other site 645657011762 decamer (pentamer of dimers) interface [polypeptide binding]; other site 645657011763 catalytic triad [active] 645657011764 peroxidatic and resolving cysteines [active] 645657011765 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 645657011766 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 645657011767 catalytic residue [active] 645657011768 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 645657011769 catalytic residues [active] 645657011770 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645657011771 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645657011772 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 645657011773 beta-galactosidase; Region: BGL; TIGR03356 645657011774 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 645657011775 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 645657011776 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645657011777 DNA-binding site [nucleotide binding]; DNA binding site 645657011778 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 645657011779 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645657011780 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 645657011781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645657011782 Walker A/P-loop; other site 645657011783 ATP binding site [chemical binding]; other site 645657011784 ABC transporter signature motif; other site 645657011785 Walker B; other site 645657011786 D-loop; other site 645657011787 H-loop/switch region; other site 645657011788 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 645657011789 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 645657011790 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 645657011791 putative dimer interface [polypeptide binding]; other site 645657011792 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 645657011793 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 645657011794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657011795 Walker A motif; other site 645657011796 ATP binding site [chemical binding]; other site 645657011797 Walker B motif; other site 645657011798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 645657011799 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 645657011800 DNA-binding interface [nucleotide binding]; DNA binding site 645657011801 Integrase core domain; Region: rve; pfam00665 645657011802 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 645657011803 HTH-like domain; Region: HTH_21; pfam13276 645657011804 Integrase core domain; Region: rve; pfam00665 645657011805 Integrase core domain; Region: rve_3; pfam13683 645657011806 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 645657011807 Transposase; Region: HTH_Tnp_1; pfam01527 645657011808 Superfamily II helicase [General function prediction only]; Region: COG1204 645657011809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645657011810 ATP binding site [chemical binding]; other site 645657011811 putative Mg++ binding site [ion binding]; other site 645657011812 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 645657011813 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 645657011814 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 645657011815 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 645657011816 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 645657011817 NAD binding site [chemical binding]; other site 645657011818 catalytic Zn binding site [ion binding]; other site 645657011819 structural Zn binding site [ion binding]; other site 645657011820 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 645657011821 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 645657011822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657011823 Coenzyme A binding pocket [chemical binding]; other site 645657011824 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657011825 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645657011826 binding surface 645657011827 TPR motif; other site 645657011828 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645657011829 Arginase family; Region: Arginase; cd09989 645657011830 agmatinase; Region: agmatinase; TIGR01230 645657011831 active site 645657011832 Mn binding site [ion binding]; other site 645657011833 oligomer interface [polypeptide binding]; other site 645657011834 S-methylmethionine transporter; Provisional; Region: PRK11387 645657011835 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 645657011836 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645657011837 inhibitor-cofactor binding pocket; inhibition site 645657011838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645657011839 catalytic residue [active] 645657011840 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 645657011841 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 645657011842 Predicted integral membrane protein [Function unknown]; Region: COG5658 645657011843 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 645657011844 SdpI/YhfL protein family; Region: SdpI; pfam13630 645657011845 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645657011846 putative DNA binding site [nucleotide binding]; other site 645657011847 putative Zn2+ binding site [ion binding]; other site 645657011848 PAS domain; Region: PAS; smart00091 645657011849 PAS domain; Region: PAS_9; pfam13426 645657011850 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 645657011851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657011852 Walker A motif; other site 645657011853 ATP binding site [chemical binding]; other site 645657011854 Walker B motif; other site 645657011855 arginine finger; other site 645657011856 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 645657011857 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 645657011858 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 645657011859 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 645657011860 protein binding site [polypeptide binding]; other site 645657011861 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 645657011862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 645657011863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 645657011864 YycH protein; Region: YycH; pfam07435 645657011865 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 645657011866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645657011867 dimerization interface [polypeptide binding]; other site 645657011868 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645657011869 putative active site [active] 645657011870 heme pocket [chemical binding]; other site 645657011871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645657011872 dimer interface [polypeptide binding]; other site 645657011873 phosphorylation site [posttranslational modification] 645657011874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645657011875 ATP binding site [chemical binding]; other site 645657011876 Mg2+ binding site [ion binding]; other site 645657011877 G-X-G motif; other site 645657011878 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645657011879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645657011880 active site 645657011881 phosphorylation site [posttranslational modification] 645657011882 intermolecular recognition site; other site 645657011883 dimerization interface [polypeptide binding]; other site 645657011884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645657011885 DNA binding site [nucleotide binding] 645657011886 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 645657011887 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 645657011888 GDP-binding site [chemical binding]; other site 645657011889 ACT binding site; other site 645657011890 IMP binding site; other site 645657011891 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657011892 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 645657011893 active site 645657011894 replicative DNA helicase; Provisional; Region: PRK05748 645657011895 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 645657011896 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 645657011897 Walker A motif; other site 645657011898 ATP binding site [chemical binding]; other site 645657011899 Walker B motif; other site 645657011900 DNA binding loops [nucleotide binding] 645657011901 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 645657011902 YycC-like protein; Region: YycC; pfam14174 645657011903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657011904 cyanate transporter; Region: CynX; TIGR00896 645657011905 putative substrate translocation pore; other site 645657011906 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 645657011907 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 645657011908 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 645657011909 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 645657011910 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 645657011911 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 645657011912 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 645657011913 diguanylate cyclase; Region: GGDEF; smart00267 645657011914 DHH family; Region: DHH; pfam01368 645657011915 DHHA1 domain; Region: DHHA1; pfam02272 645657011916 Predicted membrane protein [Function unknown]; Region: COG4241 645657011917 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 645657011918 Predicted transcriptional regulators [Transcription]; Region: COG1733 645657011919 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 645657011920 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 645657011921 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 645657011922 DHHA2 domain; Region: DHHA2; pfam02833 645657011923 ANTAR domain; Region: ANTAR; cl04297 645657011924 D-galactonate transporter; Region: 2A0114; TIGR00893 645657011925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657011926 putative substrate translocation pore; other site 645657011927 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 645657011928 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 645657011929 DNA binding residues [nucleotide binding] 645657011930 dimer interface [polypeptide binding]; other site 645657011931 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 645657011932 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 645657011933 SnoaL-like domain; Region: SnoaL_3; pfam13474 645657011934 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 645657011935 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 645657011936 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 645657011937 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 645657011938 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645657011939 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645657011940 MarR family; Region: MarR; pfam01047 645657011941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657011942 Coenzyme A binding pocket [chemical binding]; other site 645657011943 Predicted membrane protein [Function unknown]; Region: COG2364 645657011944 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 645657011945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645657011946 Coenzyme A binding pocket [chemical binding]; other site 645657011947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 645657011948 RibD C-terminal domain; Region: RibD_C; cl17279 645657011949 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 645657011950 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 645657011951 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 645657011952 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 645657011953 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 645657011954 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 645657011955 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 645657011956 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 645657011957 CAAX protease self-immunity; Region: Abi; pfam02517 645657011958 benzoate transport; Region: 2A0115; TIGR00895 645657011959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657011960 putative substrate translocation pore; other site 645657011961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645657011962 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 645657011963 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645657011964 putative metal binding site [ion binding]; other site 645657011965 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 645657011966 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 645657011967 ATP binding site [chemical binding]; other site 645657011968 substrate interface [chemical binding]; other site 645657011969 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645657011970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645657011971 Walker A motif; other site 645657011972 ATP binding site [chemical binding]; other site 645657011973 Walker B motif; other site 645657011974 arginine finger; other site 645657011975 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645657011976 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645657011977 DNA binding site [nucleotide binding] 645657011978 domain linker motif; other site 645657011979 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 645657011980 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 645657011981 active site 645657011982 putative catalytic site [active] 645657011983 DNA binding site [nucleotide binding] 645657011984 putative phosphate binding site [ion binding]; other site 645657011985 metal binding site A [ion binding]; metal-binding site 645657011986 AP binding site [nucleotide binding]; other site 645657011987 metal binding site B [ion binding]; metal-binding site 645657011988 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 645657011989 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 645657011990 dimer interface [polypeptide binding]; other site 645657011991 ssDNA binding site [nucleotide binding]; other site 645657011992 tetramer (dimer of dimers) interface [polypeptide binding]; other site 645657011993 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 645657011994 GTP-binding protein YchF; Reviewed; Region: PRK09601 645657011995 YchF GTPase; Region: YchF; cd01900 645657011996 G1 box; other site 645657011997 GTP/Mg2+ binding site [chemical binding]; other site 645657011998 Switch I region; other site 645657011999 G2 box; other site 645657012000 Switch II region; other site 645657012001 G3 box; other site 645657012002 G4 box; other site 645657012003 G5 box; other site 645657012004 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 645657012005 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 645657012006 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 645657012007 putative [4Fe-4S] binding site [ion binding]; other site 645657012008 putative molybdopterin cofactor binding site [chemical binding]; other site 645657012009 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 645657012010 molybdopterin cofactor binding site; other site 645657012011 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 645657012012 Uncharacterized membrane protein [Function unknown]; Region: COG3949 645657012013 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 645657012014 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 645657012015 ParB-like nuclease domain; Region: ParB; smart00470 645657012016 KorB domain; Region: KorB; pfam08535 645657012017 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 645657012018 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 645657012019 P-loop; other site 645657012020 Magnesium ion binding site [ion binding]; other site 645657012021 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 645657012022 Magnesium ion binding site [ion binding]; other site 645657012023 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 645657012024 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 645657012025 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 645657012026 ParB-like nuclease domain; Region: ParB; smart00470 645657012027 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 645657012028 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 645657012029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645657012030 S-adenosylmethionine binding site [chemical binding]; other site 645657012031 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 645657012032 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 645657012033 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 645657012034 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 645657012035 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 645657012036 trmE is a tRNA modification GTPase; Region: trmE; cd04164 645657012037 G1 box; other site 645657012038 GTP/Mg2+ binding site [chemical binding]; other site 645657012039 Switch I region; other site 645657012040 G2 box; other site 645657012041 Switch II region; other site 645657012042 G3 box; other site 645657012043 G4 box; other site 645657012044 G5 box; other site 645657012045 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 645657012046 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 645657012047 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 645657012048 G-X-X-G motif; other site 645657012049 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 645657012050 RxxxH motif; other site 645657012051 OxaA-like protein precursor; Provisional; Region: PRK02463 645657012052 OxaA-like protein precursor; Validated; Region: PRK02944 645657012053 ribonuclease P; Reviewed; Region: rnpA; PRK00499