-- dump date 20140618_225448 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1052585000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1052585000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1052585000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585000004 Walker A motif; other site 1052585000005 ATP binding site [chemical binding]; other site 1052585000006 Walker B motif; other site 1052585000007 arginine finger; other site 1052585000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1052585000009 DnaA box-binding interface [nucleotide binding]; other site 1052585000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1052585000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1052585000012 putative DNA binding surface [nucleotide binding]; other site 1052585000013 dimer interface [polypeptide binding]; other site 1052585000014 beta-clamp/clamp loader binding surface; other site 1052585000015 beta-clamp/translesion DNA polymerase binding surface; other site 1052585000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1052585000017 recF protein; Region: recf; TIGR00611 1052585000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1052585000019 Walker A/P-loop; other site 1052585000020 ATP binding site [chemical binding]; other site 1052585000021 Q-loop/lid; other site 1052585000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585000023 ABC transporter signature motif; other site 1052585000024 Walker B; other site 1052585000025 D-loop; other site 1052585000026 H-loop/switch region; other site 1052585000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1052585000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585000029 ATP binding site [chemical binding]; other site 1052585000030 Mg2+ binding site [ion binding]; other site 1052585000031 G-X-G motif; other site 1052585000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1052585000033 anchoring element; other site 1052585000034 dimer interface [polypeptide binding]; other site 1052585000035 ATP binding site [chemical binding]; other site 1052585000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1052585000037 active site 1052585000038 putative metal-binding site [ion binding]; other site 1052585000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1052585000040 DNA gyrase subunit A; Validated; Region: PRK05560 1052585000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1052585000042 CAP-like domain; other site 1052585000043 active site 1052585000044 primary dimer interface [polypeptide binding]; other site 1052585000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585000051 YaaC-like Protein; Region: YaaC; pfam14175 1052585000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1052585000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1052585000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1052585000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1052585000056 active site 1052585000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1052585000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1052585000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1052585000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1052585000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1052585000062 active site 1052585000063 multimer interface [polypeptide binding]; other site 1052585000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1052585000065 predicted active site [active] 1052585000066 catalytic triad [active] 1052585000067 seryl-tRNA synthetase; Provisional; Region: PRK05431 1052585000068 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1052585000069 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1052585000070 dimer interface [polypeptide binding]; other site 1052585000071 active site 1052585000072 motif 1; other site 1052585000073 motif 2; other site 1052585000074 motif 3; other site 1052585000075 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1052585000076 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1052585000077 Substrate-binding site [chemical binding]; other site 1052585000078 Substrate specificity [chemical binding]; other site 1052585000079 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1052585000080 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1052585000081 Substrate-binding site [chemical binding]; other site 1052585000082 Substrate specificity [chemical binding]; other site 1052585000083 Isochorismatase family; Region: Isochorismatase; pfam00857 1052585000084 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1052585000085 catalytic triad [active] 1052585000086 conserved cis-peptide bond; other site 1052585000087 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1052585000088 nucleoside/Zn binding site; other site 1052585000089 dimer interface [polypeptide binding]; other site 1052585000090 catalytic motif [active] 1052585000091 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1052585000092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585000093 Walker A motif; other site 1052585000094 ATP binding site [chemical binding]; other site 1052585000095 Walker B motif; other site 1052585000096 arginine finger; other site 1052585000097 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1052585000098 hypothetical protein; Validated; Region: PRK00153 1052585000099 recombination protein RecR; Reviewed; Region: recR; PRK00076 1052585000100 RecR protein; Region: RecR; pfam02132 1052585000101 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1052585000102 putative active site [active] 1052585000103 putative metal-binding site [ion binding]; other site 1052585000104 tetramer interface [polypeptide binding]; other site 1052585000105 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1052585000106 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 1052585000107 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1052585000108 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1052585000109 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1052585000110 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1052585000111 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1052585000112 homodimer interface [polypeptide binding]; other site 1052585000113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585000114 catalytic residue [active] 1052585000115 thymidylate kinase; Validated; Region: tmk; PRK00698 1052585000116 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1052585000117 TMP-binding site; other site 1052585000118 ATP-binding site [chemical binding]; other site 1052585000119 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1052585000120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 1052585000121 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1052585000122 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1052585000123 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1052585000124 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1052585000125 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1052585000126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585000127 S-adenosylmethionine binding site [chemical binding]; other site 1052585000128 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1052585000129 GIY-YIG motif/motif A; other site 1052585000130 putative active site [active] 1052585000131 putative metal binding site [ion binding]; other site 1052585000132 Predicted methyltransferases [General function prediction only]; Region: COG0313 1052585000133 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1052585000134 putative SAM binding site [chemical binding]; other site 1052585000135 putative homodimer interface [polypeptide binding]; other site 1052585000136 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1052585000137 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1052585000138 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1052585000139 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1052585000140 active site 1052585000141 HIGH motif; other site 1052585000142 KMSKS motif; other site 1052585000143 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1052585000144 tRNA binding surface [nucleotide binding]; other site 1052585000145 anticodon binding site; other site 1052585000146 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1052585000147 dimer interface [polypeptide binding]; other site 1052585000148 putative tRNA-binding site [nucleotide binding]; other site 1052585000149 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1052585000150 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1052585000151 active site 1052585000152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1052585000153 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052585000154 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052585000155 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052585000156 G5 domain; Region: G5; pfam07501 1052585000157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1052585000158 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1052585000159 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1052585000160 putative active site [active] 1052585000161 putative metal binding site [ion binding]; other site 1052585000162 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1052585000163 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1052585000164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585000165 S-adenosylmethionine binding site [chemical binding]; other site 1052585000166 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 1052585000167 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1052585000168 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052585000169 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1052585000170 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052585000171 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585000172 active site 1052585000173 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1052585000174 homotrimer interaction site [polypeptide binding]; other site 1052585000175 putative active site [active] 1052585000176 regulatory protein SpoVG; Reviewed; Region: PRK13259 1052585000177 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1052585000178 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1052585000179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585000180 active site 1052585000181 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1052585000182 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1052585000183 5S rRNA interface [nucleotide binding]; other site 1052585000184 CTC domain interface [polypeptide binding]; other site 1052585000185 L16 interface [polypeptide binding]; other site 1052585000186 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1052585000187 putative active site [active] 1052585000188 catalytic residue [active] 1052585000189 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1052585000190 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1052585000191 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1052585000192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585000193 ATP binding site [chemical binding]; other site 1052585000194 putative Mg++ binding site [ion binding]; other site 1052585000195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585000196 nucleotide binding region [chemical binding]; other site 1052585000197 ATP-binding site [chemical binding]; other site 1052585000198 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1052585000199 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1052585000200 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1052585000201 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052585000202 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1052585000203 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1052585000204 homodimer interface [polypeptide binding]; other site 1052585000205 active site 1052585000206 SAM binding site [chemical binding]; other site 1052585000207 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1052585000208 homodimer interface [polypeptide binding]; other site 1052585000209 MazG family protein; Region: mazG; TIGR00444 1052585000210 metal binding site [ion binding]; metal-binding site 1052585000211 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1052585000212 homodimer interface [polypeptide binding]; other site 1052585000213 active site 1052585000214 putative chemical substrate binding site [chemical binding]; other site 1052585000215 metal binding site [ion binding]; metal-binding site 1052585000216 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585000217 RNA binding surface [nucleotide binding]; other site 1052585000218 sporulation protein YabP; Region: spore_yabP; TIGR02892 1052585000219 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1052585000220 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1052585000221 Septum formation initiator; Region: DivIC; pfam04977 1052585000222 hypothetical protein; Provisional; Region: PRK08582 1052585000223 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1052585000224 RNA binding site [nucleotide binding]; other site 1052585000225 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1052585000226 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1052585000227 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1052585000228 metal ion-dependent adhesion site (MIDAS); other site 1052585000229 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1052585000230 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585000231 active site 1052585000232 ATP binding site [chemical binding]; other site 1052585000233 substrate binding site [chemical binding]; other site 1052585000234 activation loop (A-loop); other site 1052585000235 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1052585000236 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1052585000237 Ligand Binding Site [chemical binding]; other site 1052585000238 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1052585000239 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585000240 active site 1052585000241 FtsH Extracellular; Region: FtsH_ext; pfam06480 1052585000242 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1052585000243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585000244 Walker A motif; other site 1052585000245 ATP binding site [chemical binding]; other site 1052585000246 Walker B motif; other site 1052585000247 arginine finger; other site 1052585000248 Peptidase family M41; Region: Peptidase_M41; pfam01434 1052585000249 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052585000250 nucleotide binding site [chemical binding]; other site 1052585000251 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1052585000252 domain crossover interface; other site 1052585000253 redox-dependent activation switch; other site 1052585000254 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1052585000255 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1052585000256 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052585000257 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052585000258 dimer interface [polypeptide binding]; other site 1052585000259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585000260 catalytic residue [active] 1052585000261 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1052585000262 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1052585000263 glutamine binding [chemical binding]; other site 1052585000264 catalytic triad [active] 1052585000265 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1052585000266 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1052585000267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585000268 catalytic residue [active] 1052585000269 dihydropteroate synthase; Region: DHPS; TIGR01496 1052585000270 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1052585000271 substrate binding pocket [chemical binding]; other site 1052585000272 dimer interface [polypeptide binding]; other site 1052585000273 inhibitor binding site; inhibition site 1052585000274 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1052585000275 homooctamer interface [polypeptide binding]; other site 1052585000276 active site 1052585000277 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1052585000278 catalytic center binding site [active] 1052585000279 ATP binding site [chemical binding]; other site 1052585000280 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052585000281 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585000282 non-specific DNA binding site [nucleotide binding]; other site 1052585000283 salt bridge; other site 1052585000284 sequence-specific DNA binding site [nucleotide binding]; other site 1052585000285 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1052585000286 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1052585000287 FMN binding site [chemical binding]; other site 1052585000288 active site 1052585000289 catalytic residues [active] 1052585000290 substrate binding site [chemical binding]; other site 1052585000291 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1052585000292 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1052585000293 dimer interface [polypeptide binding]; other site 1052585000294 putative anticodon binding site; other site 1052585000295 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1052585000296 motif 1; other site 1052585000297 active site 1052585000298 motif 2; other site 1052585000299 motif 3; other site 1052585000300 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1052585000301 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1052585000302 UvrB/uvrC motif; Region: UVR; pfam02151 1052585000303 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1052585000304 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1052585000305 ADP binding site [chemical binding]; other site 1052585000306 phosphagen binding site; other site 1052585000307 substrate specificity loop; other site 1052585000308 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1052585000309 Clp amino terminal domain; Region: Clp_N; pfam02861 1052585000310 Clp amino terminal domain; Region: Clp_N; pfam02861 1052585000311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585000312 Walker A motif; other site 1052585000313 ATP binding site [chemical binding]; other site 1052585000314 Walker B motif; other site 1052585000315 arginine finger; other site 1052585000316 UvrB/uvrC motif; Region: UVR; pfam02151 1052585000317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585000318 Walker A motif; other site 1052585000319 ATP binding site [chemical binding]; other site 1052585000320 Walker B motif; other site 1052585000321 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1052585000322 DNA repair protein RadA; Provisional; Region: PRK11823 1052585000323 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1052585000324 Walker A motif/ATP binding site; other site 1052585000325 ATP binding site [chemical binding]; other site 1052585000326 Walker B motif; other site 1052585000327 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1052585000328 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1052585000329 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052585000330 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1052585000331 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1052585000332 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1052585000333 putative active site [active] 1052585000334 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1052585000335 substrate binding site; other site 1052585000336 dimer interface; other site 1052585000337 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1052585000338 homotrimer interaction site [polypeptide binding]; other site 1052585000339 zinc binding site [ion binding]; other site 1052585000340 CDP-binding sites; other site 1052585000341 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1052585000342 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1052585000343 active site 1052585000344 HIGH motif; other site 1052585000345 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1052585000346 active site 1052585000347 KMSKS motif; other site 1052585000348 serine O-acetyltransferase; Region: cysE; TIGR01172 1052585000349 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1052585000350 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1052585000351 trimer interface [polypeptide binding]; other site 1052585000352 active site 1052585000353 substrate binding site [chemical binding]; other site 1052585000354 CoA binding site [chemical binding]; other site 1052585000355 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1052585000356 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1052585000357 active site 1052585000358 HIGH motif; other site 1052585000359 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1052585000360 KMSKS motif; other site 1052585000361 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1052585000362 tRNA binding surface [nucleotide binding]; other site 1052585000363 anticodon binding site; other site 1052585000364 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1052585000365 active site 1052585000366 metal binding site [ion binding]; metal-binding site 1052585000367 dimerization interface [polypeptide binding]; other site 1052585000368 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1052585000369 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1052585000370 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1052585000371 YacP-like NYN domain; Region: NYN_YacP; cl01491 1052585000372 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1052585000373 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585000374 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1052585000375 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1052585000376 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1052585000377 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1052585000378 putative homodimer interface [polypeptide binding]; other site 1052585000379 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1052585000380 heterodimer interface [polypeptide binding]; other site 1052585000381 homodimer interface [polypeptide binding]; other site 1052585000382 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1052585000383 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1052585000384 23S rRNA interface [nucleotide binding]; other site 1052585000385 L7/L12 interface [polypeptide binding]; other site 1052585000386 putative thiostrepton binding site; other site 1052585000387 L25 interface [polypeptide binding]; other site 1052585000388 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1052585000389 mRNA/rRNA interface [nucleotide binding]; other site 1052585000390 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1052585000391 23S rRNA interface [nucleotide binding]; other site 1052585000392 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1052585000393 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1052585000394 core dimer interface [polypeptide binding]; other site 1052585000395 peripheral dimer interface [polypeptide binding]; other site 1052585000396 L10 interface [polypeptide binding]; other site 1052585000397 L11 interface [polypeptide binding]; other site 1052585000398 putative EF-Tu interaction site [polypeptide binding]; other site 1052585000399 putative EF-G interaction site [polypeptide binding]; other site 1052585000400 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1052585000401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585000402 S-adenosylmethionine binding site [chemical binding]; other site 1052585000403 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1052585000404 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1052585000405 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1052585000406 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1052585000407 RPB1 interaction site [polypeptide binding]; other site 1052585000408 RPB10 interaction site [polypeptide binding]; other site 1052585000409 RPB11 interaction site [polypeptide binding]; other site 1052585000410 RPB3 interaction site [polypeptide binding]; other site 1052585000411 RPB12 interaction site [polypeptide binding]; other site 1052585000412 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1052585000413 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1052585000414 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1052585000415 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1052585000416 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1052585000417 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1052585000418 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1052585000419 G-loop; other site 1052585000420 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1052585000421 DNA binding site [nucleotide binding] 1052585000422 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1052585000423 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1052585000424 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1052585000425 S17 interaction site [polypeptide binding]; other site 1052585000426 S8 interaction site; other site 1052585000427 16S rRNA interaction site [nucleotide binding]; other site 1052585000428 streptomycin interaction site [chemical binding]; other site 1052585000429 23S rRNA interaction site [nucleotide binding]; other site 1052585000430 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1052585000431 30S ribosomal protein S7; Validated; Region: PRK05302 1052585000432 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1052585000433 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1052585000434 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1052585000435 elongation factor Tu; Reviewed; Region: PRK00049 1052585000436 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1052585000437 G1 box; other site 1052585000438 GEF interaction site [polypeptide binding]; other site 1052585000439 GTP/Mg2+ binding site [chemical binding]; other site 1052585000440 Switch I region; other site 1052585000441 G2 box; other site 1052585000442 G3 box; other site 1052585000443 Switch II region; other site 1052585000444 G4 box; other site 1052585000445 G5 box; other site 1052585000446 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1052585000447 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1052585000448 Antibiotic Binding Site [chemical binding]; other site 1052585000449 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052585000450 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052585000451 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1052585000452 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1052585000453 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1052585000454 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1052585000455 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1052585000456 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1052585000457 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1052585000458 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1052585000459 putative translocon binding site; other site 1052585000460 protein-rRNA interface [nucleotide binding]; other site 1052585000461 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1052585000462 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1052585000463 G-X-X-G motif; other site 1052585000464 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1052585000465 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1052585000466 L27 interface [polypeptide binding]; other site 1052585000467 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1052585000468 23S rRNA interface [nucleotide binding]; other site 1052585000469 putative translocon interaction site; other site 1052585000470 signal recognition particle (SRP54) interaction site; other site 1052585000471 L23 interface [polypeptide binding]; other site 1052585000472 trigger factor interaction site; other site 1052585000473 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1052585000474 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1052585000475 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1052585000476 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1052585000477 RNA binding site [nucleotide binding]; other site 1052585000478 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1052585000479 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1052585000480 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1052585000481 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1052585000482 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1052585000483 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1052585000484 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1052585000485 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1052585000486 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1052585000487 5S rRNA interface [nucleotide binding]; other site 1052585000488 L27 interface [polypeptide binding]; other site 1052585000489 23S rRNA interface [nucleotide binding]; other site 1052585000490 L5 interface [polypeptide binding]; other site 1052585000491 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1052585000492 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1052585000493 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1052585000494 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1052585000495 23S rRNA binding site [nucleotide binding]; other site 1052585000496 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1052585000497 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1052585000498 SecY translocase; Region: SecY; pfam00344 1052585000499 adenylate kinase; Reviewed; Region: adk; PRK00279 1052585000500 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1052585000501 AMP-binding site [chemical binding]; other site 1052585000502 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1052585000503 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1052585000504 active site 1052585000505 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 1052585000506 RNA binding site [nucleotide binding]; other site 1052585000507 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1052585000508 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1052585000509 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1052585000510 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1052585000511 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1052585000512 alphaNTD homodimer interface [polypeptide binding]; other site 1052585000513 alphaNTD - beta interaction site [polypeptide binding]; other site 1052585000514 alphaNTD - beta' interaction site [polypeptide binding]; other site 1052585000515 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1052585000516 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1052585000517 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1052585000518 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052585000519 Walker A/P-loop; other site 1052585000520 ATP binding site [chemical binding]; other site 1052585000521 Q-loop/lid; other site 1052585000522 ABC transporter signature motif; other site 1052585000523 Walker B; other site 1052585000524 D-loop; other site 1052585000525 H-loop/switch region; other site 1052585000526 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1052585000527 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1052585000528 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1052585000529 dimerization interface 3.5A [polypeptide binding]; other site 1052585000530 active site 1052585000531 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1052585000532 23S rRNA interface [nucleotide binding]; other site 1052585000533 L3 interface [polypeptide binding]; other site 1052585000534 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1052585000535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585000536 S-adenosylmethionine binding site [chemical binding]; other site 1052585000537 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1052585000538 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1052585000539 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052585000540 active site 1052585000541 metal binding site [ion binding]; metal-binding site 1052585000542 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1052585000543 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1052585000544 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1052585000545 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052585000546 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 1052585000547 NodB motif; other site 1052585000548 putative active site [active] 1052585000549 putative catalytic site [active] 1052585000550 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1052585000551 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1052585000552 Int/Topo IB signature motif; other site 1052585000553 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1052585000554 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 1052585000555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585000556 non-specific DNA binding site [nucleotide binding]; other site 1052585000557 salt bridge; other site 1052585000558 sequence-specific DNA binding site [nucleotide binding]; other site 1052585000559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585000560 non-specific DNA binding site [nucleotide binding]; other site 1052585000561 salt bridge; other site 1052585000562 sequence-specific DNA binding site [nucleotide binding]; other site 1052585000563 AAA domain; Region: AAA_23; pfam13476 1052585000564 RecT family; Region: RecT; cl04285 1052585000565 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585000566 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 1052585000567 replicative DNA helicase; Region: DnaB; TIGR00665 1052585000568 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1052585000569 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1052585000570 Walker A motif; other site 1052585000571 ATP binding site [chemical binding]; other site 1052585000572 Walker B motif; other site 1052585000573 DNA binding loops [nucleotide binding] 1052585000574 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1052585000575 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1052585000576 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1052585000577 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1052585000578 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1052585000579 active site 1052585000580 FMN binding site [chemical binding]; other site 1052585000581 substrate binding site [chemical binding]; other site 1052585000582 homotetramer interface [polypeptide binding]; other site 1052585000583 catalytic residue [active] 1052585000584 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585000585 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052585000586 active site 1052585000587 metal binding site [ion binding]; metal-binding site 1052585000588 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1052585000589 ParB-like nuclease domain; Region: ParB; smart00470 1052585000590 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1052585000591 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1052585000592 cofactor binding site; other site 1052585000593 DNA binding site [nucleotide binding] 1052585000594 substrate interaction site [chemical binding]; other site 1052585000595 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1052585000596 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1052585000597 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1052585000598 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1052585000599 Terminase-like family; Region: Terminase_6; pfam03237 1052585000600 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1052585000601 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1052585000602 Phage capsid family; Region: Phage_capsid; pfam05065 1052585000603 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1052585000604 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1052585000605 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1052585000606 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1052585000607 Phage XkdN-like protein; Region: XkdN; pfam08890 1052585000608 Phage-related minor tail protein [Function unknown]; Region: COG5280 1052585000609 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1052585000610 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052585000611 catalytic residue [active] 1052585000612 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1052585000613 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585000614 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1052585000615 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1052585000616 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1052585000617 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1052585000618 XkdW protein; Region: XkdW; pfam09636 1052585000619 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 1052585000620 Holin family; Region: Phage_holin_4; cl01989 1052585000621 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1052585000622 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052585000623 amidase catalytic site [active] 1052585000624 Zn binding residues [ion binding]; other site 1052585000625 substrate binding site [chemical binding]; other site 1052585000626 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585000627 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052585000628 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052585000629 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052585000630 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1052585000631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585000632 binding surface 1052585000633 TPR motif; other site 1052585000634 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585000635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585000636 binding surface 1052585000637 TPR motif; other site 1052585000638 YolD-like protein; Region: YolD; pfam08863 1052585000639 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1052585000640 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1052585000641 Int/Topo IB signature motif; other site 1052585000642 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1052585000643 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 1052585000644 GatB domain; Region: GatB_Yqey; cl11497 1052585000645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585000646 non-specific DNA binding site [nucleotide binding]; other site 1052585000647 salt bridge; other site 1052585000648 sequence-specific DNA binding site [nucleotide binding]; other site 1052585000649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585000650 non-specific DNA binding site [nucleotide binding]; other site 1052585000651 salt bridge; other site 1052585000652 sequence-specific DNA binding site [nucleotide binding]; other site 1052585000653 AAA domain; Region: AAA_23; pfam13476 1052585000654 RecT family; Region: RecT; cl04285 1052585000655 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585000656 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 1052585000657 replicative DNA helicase; Region: DnaB; TIGR00665 1052585000658 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1052585000659 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1052585000660 Walker A motif; other site 1052585000661 ATP binding site [chemical binding]; other site 1052585000662 Walker B motif; other site 1052585000663 DNA binding loops [nucleotide binding] 1052585000664 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1052585000665 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1052585000666 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1052585000667 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1052585000668 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1052585000669 active site 1052585000670 FMN binding site [chemical binding]; other site 1052585000671 substrate binding site [chemical binding]; other site 1052585000672 homotetramer interface [polypeptide binding]; other site 1052585000673 catalytic residue [active] 1052585000674 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585000675 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052585000676 active site 1052585000677 metal binding site [ion binding]; metal-binding site 1052585000678 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1052585000679 ParB-like nuclease domain; Region: ParB; smart00470 1052585000680 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1052585000681 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1052585000682 cofactor binding site; other site 1052585000683 DNA binding site [nucleotide binding] 1052585000684 substrate interaction site [chemical binding]; other site 1052585000685 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1052585000686 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1052585000687 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1052585000688 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1052585000689 Terminase-like family; Region: Terminase_6; pfam03237 1052585000690 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1052585000691 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1052585000692 Phage capsid family; Region: Phage_capsid; pfam05065 1052585000693 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1052585000694 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1052585000695 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1052585000696 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1052585000697 Phage XkdN-like protein; Region: XkdN; pfam08890 1052585000698 Phage-related minor tail protein [Function unknown]; Region: COG5280 1052585000699 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1052585000700 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052585000701 catalytic residue [active] 1052585000702 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1052585000703 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585000704 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1052585000705 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1052585000706 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1052585000707 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1052585000708 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1052585000709 XkdW protein; Region: XkdW; pfam09636 1052585000710 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 1052585000711 Holin family; Region: Phage_holin_4; cl01989 1052585000712 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1052585000713 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052585000714 amidase catalytic site [active] 1052585000715 Zn binding residues [ion binding]; other site 1052585000716 substrate binding site [chemical binding]; other site 1052585000717 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585000718 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052585000719 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052585000720 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052585000721 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1052585000722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585000723 binding surface 1052585000724 TPR motif; other site 1052585000725 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585000726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585000727 binding surface 1052585000728 TPR motif; other site 1052585000729 YolD-like protein; Region: YolD; pfam08863 1052585000730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585000731 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585000732 putative substrate translocation pore; other site 1052585000733 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1052585000734 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585000735 inhibitor-cofactor binding pocket; inhibition site 1052585000736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585000737 catalytic residue [active] 1052585000738 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1052585000739 active site 1052585000740 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052585000741 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1052585000742 NAD(P) binding site [chemical binding]; other site 1052585000743 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1052585000744 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1052585000745 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1052585000746 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1052585000747 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1052585000748 Sodium Bile acid symporter family; Region: SBF; cl17470 1052585000749 Sodium Bile acid symporter family; Region: SBF; cl17470 1052585000750 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1052585000751 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052585000752 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585000753 dimer interface [polypeptide binding]; other site 1052585000754 putative PBP binding regions; other site 1052585000755 ABC-ATPase subunit interface; other site 1052585000756 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052585000757 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585000758 ABC-ATPase subunit interface; other site 1052585000759 dimer interface [polypeptide binding]; other site 1052585000760 putative PBP binding regions; other site 1052585000761 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052585000762 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052585000763 putative ligand binding residues [chemical binding]; other site 1052585000764 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585000765 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585000766 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052585000767 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052585000768 putative ligand binding residues [chemical binding]; other site 1052585000769 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 1052585000770 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1052585000771 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1052585000772 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1052585000773 putative periplasmic esterase; Provisional; Region: PRK03642 1052585000774 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052585000775 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1052585000776 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585000777 active site turn [active] 1052585000778 phosphorylation site [posttranslational modification] 1052585000779 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052585000780 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1052585000781 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052585000782 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1052585000783 putative active site [active] 1052585000784 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1052585000785 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1052585000786 putative active site [active] 1052585000787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052585000788 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1052585000789 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1052585000790 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585000791 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585000792 DNA binding residues [nucleotide binding] 1052585000793 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1052585000794 Putative zinc-finger; Region: zf-HC2; pfam13490 1052585000795 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1052585000796 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1052585000797 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052585000798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1052585000799 YbbR-like protein; Region: YbbR; pfam07949 1052585000800 YbbR-like protein; Region: YbbR; pfam07949 1052585000801 YbbR-like protein; Region: YbbR; pfam07949 1052585000802 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1052585000803 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1052585000804 active site 1052585000805 substrate binding site [chemical binding]; other site 1052585000806 metal binding site [ion binding]; metal-binding site 1052585000807 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1052585000808 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1052585000809 glutaminase active site [active] 1052585000810 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1052585000811 dimer interface [polypeptide binding]; other site 1052585000812 active site 1052585000813 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1052585000814 dimer interface [polypeptide binding]; other site 1052585000815 active site 1052585000816 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1052585000817 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1052585000818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1052585000819 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1052585000820 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1052585000821 zinc binding site [ion binding]; other site 1052585000822 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1052585000823 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585000824 dimerization interface [polypeptide binding]; other site 1052585000825 putative DNA binding site [nucleotide binding]; other site 1052585000826 putative Zn2+ binding site [ion binding]; other site 1052585000827 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052585000828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585000829 putative substrate translocation pore; other site 1052585000830 HEAT repeats; Region: HEAT_2; pfam13646 1052585000831 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052585000832 Beta-lactamase; Region: Beta-lactamase; pfam00144 1052585000833 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052585000834 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052585000835 DNA binding residues [nucleotide binding] 1052585000836 drug binding residues [chemical binding]; other site 1052585000837 dimer interface [polypeptide binding]; other site 1052585000838 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1052585000839 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585000840 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585000841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585000842 active site 1052585000843 phosphorylation site [posttranslational modification] 1052585000844 intermolecular recognition site; other site 1052585000845 dimerization interface [polypeptide binding]; other site 1052585000846 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585000847 DNA binding site [nucleotide binding] 1052585000848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585000849 HAMP domain; Region: HAMP; pfam00672 1052585000850 dimerization interface [polypeptide binding]; other site 1052585000851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585000852 dimer interface [polypeptide binding]; other site 1052585000853 phosphorylation site [posttranslational modification] 1052585000854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585000855 ATP binding site [chemical binding]; other site 1052585000856 Mg2+ binding site [ion binding]; other site 1052585000857 G-X-G motif; other site 1052585000858 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1052585000859 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1052585000860 active site 1052585000861 ATP binding site [chemical binding]; other site 1052585000862 substrate binding site [chemical binding]; other site 1052585000863 activation loop (A-loop); other site 1052585000864 putative transport protein YifK; Provisional; Region: PRK10746 1052585000865 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1052585000866 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1052585000867 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052585000868 Cytochrome P450; Region: p450; cl12078 1052585000869 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1052585000870 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052585000871 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052585000872 PhoU domain; Region: PhoU; pfam01895 1052585000873 PhoU domain; Region: PhoU; pfam01895 1052585000874 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1052585000875 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1052585000876 active site 1052585000877 catalytic site [active] 1052585000878 metal binding site [ion binding]; metal-binding site 1052585000879 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1052585000880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585000881 putative substrate translocation pore; other site 1052585000882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585000883 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1052585000884 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585000885 MarR family; Region: MarR; pfam01047 1052585000886 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052585000887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585000888 Coenzyme A binding pocket [chemical binding]; other site 1052585000889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585000890 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585000891 putative substrate translocation pore; other site 1052585000892 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052585000893 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052585000894 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052585000895 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052585000896 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1052585000897 active site 1052585000898 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052585000899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585000900 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585000901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585000902 Phage lysis protein, holin; Region: Phage_holin; pfam04688 1052585000903 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1052585000904 catalytic residue [active] 1052585000905 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1052585000906 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585000907 ATP-grasp domain; Region: ATP-grasp; pfam02222 1052585000908 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1052585000909 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1052585000910 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052585000911 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1052585000912 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1052585000913 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1052585000914 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1052585000915 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1052585000916 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1052585000917 active site residue [active] 1052585000918 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1052585000919 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052585000920 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052585000921 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052585000922 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1052585000923 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585000924 active site turn [active] 1052585000925 phosphorylation site [posttranslational modification] 1052585000926 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1052585000927 HPr interaction site; other site 1052585000928 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585000929 active site 1052585000930 phosphorylation site [posttranslational modification] 1052585000931 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1052585000932 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1052585000933 active site 1052585000934 trimer interface [polypeptide binding]; other site 1052585000935 allosteric site; other site 1052585000936 active site lid [active] 1052585000937 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052585000938 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052585000939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585000940 DNA-binding site [nucleotide binding]; DNA binding site 1052585000941 UTRA domain; Region: UTRA; pfam07702 1052585000942 Predicted integral membrane protein [Function unknown]; Region: COG5658 1052585000943 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1052585000944 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1052585000945 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1052585000946 homodimer interface [polypeptide binding]; other site 1052585000947 substrate-cofactor binding pocket; other site 1052585000948 catalytic residue [active] 1052585000949 S-methylmethionine transporter; Provisional; Region: PRK11387 1052585000950 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1052585000951 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1052585000952 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052585000953 amino acid carrier protein; Region: agcS; TIGR00835 1052585000954 glutaminase; Reviewed; Region: PRK12357 1052585000955 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1052585000956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585000957 Response regulator receiver domain; Region: Response_reg; pfam00072 1052585000958 active site 1052585000959 phosphorylation site [posttranslational modification] 1052585000960 intermolecular recognition site; other site 1052585000961 dimerization interface [polypeptide binding]; other site 1052585000962 YcbB domain; Region: YcbB; pfam08664 1052585000963 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1052585000964 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1052585000965 putative active site [active] 1052585000966 catalytic residue [active] 1052585000967 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1052585000968 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052585000969 NAD(P) binding site [chemical binding]; other site 1052585000970 catalytic residues [active] 1052585000971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585000972 D-galactonate transporter; Region: 2A0114; TIGR00893 1052585000973 putative substrate translocation pore; other site 1052585000974 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1052585000975 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1052585000976 active site 1052585000977 tetramer interface [polypeptide binding]; other site 1052585000978 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1052585000979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585000980 DNA-binding site [nucleotide binding]; DNA binding site 1052585000981 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1052585000982 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1052585000983 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1052585000984 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1052585000985 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1052585000986 putative active site [active] 1052585000987 putative substrate binding site [chemical binding]; other site 1052585000988 Phosphotransferase enzyme family; Region: APH; pfam01636 1052585000989 ATP binding site [chemical binding]; other site 1052585000990 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1052585000991 dodecamer interface 1 [polypeptide binding]; other site 1052585000992 dodecamer interface 2 [polypeptide binding]; other site 1052585000993 trimer interface [polypeptide binding]; other site 1052585000994 TRAP binding interface [polypeptide binding]; other site 1052585000995 Zn binding site [ion binding]; other site 1052585000996 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052585000997 EamA-like transporter family; Region: EamA; pfam00892 1052585000998 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585000999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585001000 active site 1052585001001 phosphorylation site [posttranslational modification] 1052585001002 intermolecular recognition site; other site 1052585001003 dimerization interface [polypeptide binding]; other site 1052585001004 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585001005 DNA binding site [nucleotide binding] 1052585001006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585001007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585001008 dimer interface [polypeptide binding]; other site 1052585001009 phosphorylation site [posttranslational modification] 1052585001010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001011 ATP binding site [chemical binding]; other site 1052585001012 Mg2+ binding site [ion binding]; other site 1052585001013 G-X-G motif; other site 1052585001014 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585001015 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1052585001016 Walker A/P-loop; other site 1052585001017 ATP binding site [chemical binding]; other site 1052585001018 Q-loop/lid; other site 1052585001019 ABC transporter signature motif; other site 1052585001020 Walker B; other site 1052585001021 D-loop; other site 1052585001022 H-loop/switch region; other site 1052585001023 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1052585001024 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1052585001025 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 1052585001026 reactive center loop; other site 1052585001027 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1052585001028 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052585001029 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1052585001030 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1052585001031 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1052585001032 putative active site [active] 1052585001033 putative metal binding site [ion binding]; other site 1052585001034 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1052585001035 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1052585001036 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1052585001037 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1052585001038 putative substrate binding pocket [chemical binding]; other site 1052585001039 AC domain interface; other site 1052585001040 catalytic triad [active] 1052585001041 AB domain interface; other site 1052585001042 interchain disulfide; other site 1052585001043 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1052585001044 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052585001045 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585001046 catalytic residue [active] 1052585001047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001048 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585001049 putative substrate translocation pore; other site 1052585001050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585001051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585001052 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1052585001053 active site 1052585001054 homotetramer interface [polypeptide binding]; other site 1052585001055 homodimer interface [polypeptide binding]; other site 1052585001056 Lipase (class 2); Region: Lipase_2; pfam01674 1052585001057 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585001058 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1052585001059 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1052585001060 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1052585001061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001062 ATP binding site [chemical binding]; other site 1052585001063 Mg2+ binding site [ion binding]; other site 1052585001064 G-X-G motif; other site 1052585001065 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1052585001066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585001067 active site 1052585001068 phosphorylation site [posttranslational modification] 1052585001069 intermolecular recognition site; other site 1052585001070 dimerization interface [polypeptide binding]; other site 1052585001071 LytTr DNA-binding domain; Region: LytTR; pfam04397 1052585001072 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052585001073 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 1052585001074 Walker A/P-loop; other site 1052585001075 ATP binding site [chemical binding]; other site 1052585001076 Q-loop/lid; other site 1052585001077 ABC transporter signature motif; other site 1052585001078 Walker B; other site 1052585001079 D-loop; other site 1052585001080 H-loop/switch region; other site 1052585001081 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052585001082 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1052585001083 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585001084 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052585001085 active site 1052585001086 catalytic tetrad [active] 1052585001087 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052585001088 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1052585001089 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1052585001090 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585001091 binding surface 1052585001092 TPR motif; other site 1052585001093 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585001094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585001095 binding surface 1052585001096 TPR motif; other site 1052585001097 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1052585001098 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1052585001099 NAD binding site [chemical binding]; other site 1052585001100 homodimer interface [polypeptide binding]; other site 1052585001101 active site 1052585001102 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052585001103 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052585001104 Ca binding site [ion binding]; other site 1052585001105 active site 1052585001106 catalytic site [active] 1052585001107 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1052585001108 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1052585001109 metal binding site [ion binding]; metal-binding site 1052585001110 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052585001111 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1052585001112 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1052585001113 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1052585001114 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1052585001115 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052585001116 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052585001117 putative metal binding site [ion binding]; other site 1052585001118 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052585001119 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052585001120 putative metal binding site [ion binding]; other site 1052585001121 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052585001122 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052585001123 putative metal binding site [ion binding]; other site 1052585001124 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1052585001125 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1052585001126 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 1052585001127 benzoate transport; Region: 2A0115; TIGR00895 1052585001128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001129 putative substrate translocation pore; other site 1052585001130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585001131 dimerization interface [polypeptide binding]; other site 1052585001132 putative DNA binding site [nucleotide binding]; other site 1052585001133 putative Zn2+ binding site [ion binding]; other site 1052585001134 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1052585001135 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1052585001136 Walker A/P-loop; other site 1052585001137 ATP binding site [chemical binding]; other site 1052585001138 Q-loop/lid; other site 1052585001139 ABC transporter signature motif; other site 1052585001140 Walker B; other site 1052585001141 D-loop; other site 1052585001142 H-loop/switch region; other site 1052585001143 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1052585001144 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1052585001145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585001146 dimer interface [polypeptide binding]; other site 1052585001147 conserved gate region; other site 1052585001148 putative PBP binding loops; other site 1052585001149 ABC-ATPase subunit interface; other site 1052585001150 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1052585001151 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1052585001152 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1052585001153 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1052585001154 amidohydrolase; Region: amidohydrolases; TIGR01891 1052585001155 metal binding site [ion binding]; metal-binding site 1052585001156 putative dimer interface [polypeptide binding]; other site 1052585001157 Predicted membrane protein [Function unknown]; Region: COG1288 1052585001158 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1052585001159 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1052585001160 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1052585001161 active site 1052585001162 Ca binding site [ion binding]; other site 1052585001163 catalytic site [active] 1052585001164 Aamy_C domain; Region: Aamy_C; smart00632 1052585001165 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1052585001166 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1052585001167 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585001168 NAD binding site [chemical binding]; other site 1052585001169 dimer interface [polypeptide binding]; other site 1052585001170 substrate binding site [chemical binding]; other site 1052585001171 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1052585001172 L-lactate permease; Region: Lactate_perm; pfam02652 1052585001173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585001175 putative substrate translocation pore; other site 1052585001176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001177 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585001178 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585001179 putative DNA binding site [nucleotide binding]; other site 1052585001180 putative Zn2+ binding site [ion binding]; other site 1052585001181 LysE type translocator; Region: LysE; pfam01810 1052585001182 Uncharacterized conserved protein [Function unknown]; Region: COG3403 1052585001183 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052585001184 Spore germination protein; Region: Spore_permease; cl17796 1052585001185 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1052585001186 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1052585001187 NAD+ synthetase; Region: nadE; TIGR00552 1052585001188 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1052585001189 homodimer interface [polypeptide binding]; other site 1052585001190 NAD binding pocket [chemical binding]; other site 1052585001191 ATP binding pocket [chemical binding]; other site 1052585001192 Mg binding site [ion binding]; other site 1052585001193 active-site loop [active] 1052585001194 AAA domain; Region: AAA_18; pfam13238 1052585001195 shikimate kinase; Reviewed; Region: aroK; PRK00131 1052585001196 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1052585001197 ADP binding site [chemical binding]; other site 1052585001198 magnesium binding site [ion binding]; other site 1052585001199 putative shikimate binding site; other site 1052585001200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585001201 S-adenosylmethionine binding site [chemical binding]; other site 1052585001202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585001203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585001204 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585001205 dimerization interface [polypeptide binding]; other site 1052585001206 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1052585001207 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1052585001208 Proline dehydrogenase; Region: Pro_dh; cl03282 1052585001209 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1052585001210 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1052585001211 Na binding site [ion binding]; other site 1052585001212 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052585001213 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1052585001214 Predicted membrane protein [Function unknown]; Region: COG3689 1052585001215 Predicted permeases [General function prediction only]; Region: COG0701 1052585001216 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052585001217 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 1052585001218 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1052585001219 active site 1052585001220 SAM binding site [chemical binding]; other site 1052585001221 homodimer interface [polypeptide binding]; other site 1052585001222 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052585001223 active site 1052585001224 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1052585001225 [2Fe-2S] cluster binding site [ion binding]; other site 1052585001226 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1052585001227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585001228 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1052585001229 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1052585001230 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052585001231 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1052585001232 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1052585001233 [4Fe-4S] binding site [ion binding]; other site 1052585001234 molybdopterin cofactor binding site; other site 1052585001235 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1052585001236 molybdopterin cofactor binding site; other site 1052585001237 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1052585001238 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052585001239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585001240 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1052585001241 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1052585001242 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052585001243 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1052585001244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001245 putative substrate translocation pore; other site 1052585001246 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1052585001247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1052585001248 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1052585001249 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052585001250 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1052585001251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585001252 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1052585001253 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1052585001254 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1052585001255 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052585001256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585001257 dimer interface [polypeptide binding]; other site 1052585001258 conserved gate region; other site 1052585001259 putative PBP binding loops; other site 1052585001260 ABC-ATPase subunit interface; other site 1052585001261 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052585001262 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052585001263 substrate binding pocket [chemical binding]; other site 1052585001264 membrane-bound complex binding site; other site 1052585001265 hinge residues; other site 1052585001266 Alcohol dehydrogenase GroES-associated; Region: ADH_N_assoc; pfam13823 1052585001267 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1052585001268 RDD family; Region: RDD; pfam06271 1052585001269 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1052585001270 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585001271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585001272 putative Zn2+ binding site [ion binding]; other site 1052585001273 putative DNA binding site [nucleotide binding]; other site 1052585001274 hypothetical protein; Provisional; Region: PRK09272 1052585001275 Predicted ATPase [General function prediction only]; Region: COG3910 1052585001276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585001277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1052585001278 Walker A/P-loop; other site 1052585001279 Walker A/P-loop; other site 1052585001280 ATP binding site [chemical binding]; other site 1052585001281 ATP binding site [chemical binding]; other site 1052585001282 Q-loop/lid; other site 1052585001283 ABC transporter signature motif; other site 1052585001284 Walker B; other site 1052585001285 D-loop; other site 1052585001286 H-loop/switch region; other site 1052585001287 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1052585001288 beta-galactosidase; Region: BGL; TIGR03356 1052585001289 Competence protein J (ComJ); Region: ComJ; pfam11033 1052585001290 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1052585001291 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1052585001292 dimerization interface [polypeptide binding]; other site 1052585001293 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585001294 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585001295 dimer interface [polypeptide binding]; other site 1052585001296 putative CheW interface [polypeptide binding]; other site 1052585001297 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052585001298 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1052585001299 tetramer interface [polypeptide binding]; other site 1052585001300 active site 1052585001301 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1052585001302 active site 1052585001303 dimer interface [polypeptide binding]; other site 1052585001304 magnesium binding site [ion binding]; other site 1052585001305 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052585001306 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052585001307 Condensation domain; Region: Condensation; pfam00668 1052585001308 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585001309 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052585001310 acyl-activating enzyme (AAE) consensus motif; other site 1052585001311 AMP binding site [chemical binding]; other site 1052585001312 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585001313 Condensation domain; Region: Condensation; pfam00668 1052585001314 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585001315 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585001316 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052585001317 acyl-activating enzyme (AAE) consensus motif; other site 1052585001318 AMP binding site [chemical binding]; other site 1052585001319 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585001320 Condensation domain; Region: Condensation; pfam00668 1052585001321 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585001322 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585001323 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052585001324 acyl-activating enzyme (AAE) consensus motif; other site 1052585001325 AMP binding site [chemical binding]; other site 1052585001326 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585001327 Condensation domain; Region: Condensation; pfam00668 1052585001328 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052585001329 Condensation domain; Region: Condensation; pfam00668 1052585001330 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585001331 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052585001332 acyl-activating enzyme (AAE) consensus motif; other site 1052585001333 AMP binding site [chemical binding]; other site 1052585001334 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585001335 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1052585001336 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1052585001337 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1052585001338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001339 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585001340 putative substrate translocation pore; other site 1052585001341 YcxB-like protein; Region: YcxB; pfam14317 1052585001342 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052585001343 EamA-like transporter family; Region: EamA; pfam00892 1052585001344 EamA-like transporter family; Region: EamA; pfam00892 1052585001345 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585001346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585001347 DNA-binding site [nucleotide binding]; DNA binding site 1052585001348 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585001349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585001350 homodimer interface [polypeptide binding]; other site 1052585001351 catalytic residue [active] 1052585001352 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1052585001353 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 1052585001354 Predicted membrane protein [Function unknown]; Region: COG2364 1052585001355 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585001356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585001357 binding surface 1052585001358 TPR motif; other site 1052585001359 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585001360 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052585001361 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052585001362 Walker A/P-loop; other site 1052585001363 ATP binding site [chemical binding]; other site 1052585001364 Q-loop/lid; other site 1052585001365 ABC transporter signature motif; other site 1052585001366 Walker B; other site 1052585001367 D-loop; other site 1052585001368 H-loop/switch region; other site 1052585001369 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052585001370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585001371 dimer interface [polypeptide binding]; other site 1052585001372 conserved gate region; other site 1052585001373 putative PBP binding loops; other site 1052585001374 ABC-ATPase subunit interface; other site 1052585001375 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052585001376 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052585001377 substrate binding pocket [chemical binding]; other site 1052585001378 membrane-bound complex binding site; other site 1052585001379 hinge residues; other site 1052585001380 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585001381 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585001382 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585001383 dimerization interface [polypeptide binding]; other site 1052585001384 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 1052585001385 Flavoprotein; Region: Flavoprotein; pfam02441 1052585001386 UbiD family decarboxylase; Region: TIGR00148 1052585001387 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1052585001388 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052585001389 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1052585001390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001391 putative substrate translocation pore; other site 1052585001392 POT family; Region: PTR2; pfam00854 1052585001393 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1052585001394 Right handed beta helix region; Region: Beta_helix; pfam13229 1052585001395 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052585001396 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052585001397 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052585001398 Spore germination protein; Region: Spore_permease; pfam03845 1052585001399 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585001400 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052585001401 Walker A/P-loop; other site 1052585001402 ATP binding site [chemical binding]; other site 1052585001403 Q-loop/lid; other site 1052585001404 ABC transporter signature motif; other site 1052585001405 Walker B; other site 1052585001406 D-loop; other site 1052585001407 H-loop/switch region; other site 1052585001408 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052585001409 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052585001410 FtsX-like permease family; Region: FtsX; pfam02687 1052585001411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585001412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585001413 active site 1052585001414 phosphorylation site [posttranslational modification] 1052585001415 intermolecular recognition site; other site 1052585001416 dimerization interface [polypeptide binding]; other site 1052585001417 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585001418 DNA binding site [nucleotide binding] 1052585001419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585001420 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585001421 dimerization interface [polypeptide binding]; other site 1052585001422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585001423 dimer interface [polypeptide binding]; other site 1052585001424 phosphorylation site [posttranslational modification] 1052585001425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001426 ATP binding site [chemical binding]; other site 1052585001427 Mg2+ binding site [ion binding]; other site 1052585001428 G-X-G motif; other site 1052585001429 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585001430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585001431 TPR motif; other site 1052585001432 binding surface 1052585001433 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585001434 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1052585001435 aspartate kinase; Reviewed; Region: PRK09034 1052585001436 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1052585001437 putative catalytic residues [active] 1052585001438 putative nucleotide binding site [chemical binding]; other site 1052585001439 putative aspartate binding site [chemical binding]; other site 1052585001440 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1052585001441 allosteric regulatory residue; other site 1052585001442 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1052585001443 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052585001444 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585001445 ABC-ATPase subunit interface; other site 1052585001446 dimer interface [polypeptide binding]; other site 1052585001447 putative PBP binding regions; other site 1052585001448 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052585001449 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585001450 ABC-ATPase subunit interface; other site 1052585001451 dimer interface [polypeptide binding]; other site 1052585001452 putative PBP binding regions; other site 1052585001453 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1052585001454 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052585001455 Walker A/P-loop; other site 1052585001456 ATP binding site [chemical binding]; other site 1052585001457 Q-loop/lid; other site 1052585001458 ABC transporter signature motif; other site 1052585001459 Walker B; other site 1052585001460 D-loop; other site 1052585001461 H-loop/switch region; other site 1052585001462 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1052585001463 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1052585001464 putative ligand binding residues [chemical binding]; other site 1052585001465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001466 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585001467 putative substrate translocation pore; other site 1052585001468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585001470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585001471 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1052585001472 dimer interface [polypeptide binding]; other site 1052585001473 FMN binding site [chemical binding]; other site 1052585001474 NADPH bind site [chemical binding]; other site 1052585001475 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1052585001476 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585001477 dimerization interface [polypeptide binding]; other site 1052585001478 putative DNA binding site [nucleotide binding]; other site 1052585001479 putative Zn2+ binding site [ion binding]; other site 1052585001480 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585001481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585001482 DNA-binding site [nucleotide binding]; DNA binding site 1052585001483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585001484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585001485 homodimer interface [polypeptide binding]; other site 1052585001486 catalytic residue [active] 1052585001487 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1052585001488 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585001489 inhibitor-cofactor binding pocket; inhibition site 1052585001490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585001491 catalytic residue [active] 1052585001492 succinic semialdehyde dehydrogenase; Region: PLN02278 1052585001493 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1052585001494 tetramerization interface [polypeptide binding]; other site 1052585001495 NAD(P) binding site [chemical binding]; other site 1052585001496 catalytic residues [active] 1052585001497 Sugar transport protein; Region: Sugar_transport; pfam06800 1052585001498 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1052585001499 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1052585001500 NAD binding site [chemical binding]; other site 1052585001501 homodimer interface [polypeptide binding]; other site 1052585001502 active site 1052585001503 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1052585001504 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1052585001505 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1052585001506 YtkA-like; Region: YtkA; pfam13115 1052585001507 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052585001508 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1052585001509 NosL; Region: NosL; cl01769 1052585001510 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1052585001511 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1052585001512 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1052585001513 active site 1052585001514 P-loop; other site 1052585001515 phosphorylation site [posttranslational modification] 1052585001516 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052585001517 active site 1052585001518 phosphorylation site [posttranslational modification] 1052585001519 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1052585001520 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1052585001521 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1052585001522 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1052585001523 tartrate dehydrogenase; Provisional; Region: PRK08194 1052585001524 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1052585001525 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1052585001526 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1052585001527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585001528 active site 1052585001529 motif I; other site 1052585001530 motif II; other site 1052585001531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585001532 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1052585001533 putative active site [active] 1052585001534 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1052585001535 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1052585001536 hypothetical protein; Provisional; Region: PRK05463 1052585001537 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1052585001538 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1052585001539 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1052585001540 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1052585001541 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1052585001542 Bacterial transcriptional regulator; Region: IclR; pfam01614 1052585001543 Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755 1052585001544 active site 1052585001545 catalytic triad [active] 1052585001546 oxyanion hole [active] 1052585001547 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1052585001548 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1052585001549 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1052585001550 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052585001551 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585001552 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052585001553 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585001554 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052585001555 active site 1052585001556 catalytic tetrad [active] 1052585001557 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052585001558 HTH domain; Region: HTH_11; pfam08279 1052585001559 PRD domain; Region: PRD; pfam00874 1052585001560 PRD domain; Region: PRD; pfam00874 1052585001561 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052585001562 active site 1052585001563 P-loop; other site 1052585001564 phosphorylation site [posttranslational modification] 1052585001565 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1052585001566 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1052585001567 acyl-activating enzyme (AAE) consensus motif; other site 1052585001568 putative AMP binding site [chemical binding]; other site 1052585001569 putative active site [active] 1052585001570 putative CoA binding site [chemical binding]; other site 1052585001571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585001572 S-adenosylmethionine binding site [chemical binding]; other site 1052585001573 short chain dehydrogenase; Provisional; Region: PRK06701 1052585001574 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052585001575 NAD binding site [chemical binding]; other site 1052585001576 metal binding site [ion binding]; metal-binding site 1052585001577 active site 1052585001578 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1052585001579 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052585001580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052585001581 Coenzyme A binding pocket [chemical binding]; other site 1052585001582 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1052585001583 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1052585001584 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1052585001585 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1052585001586 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052585001587 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1052585001588 putative DNA binding site [nucleotide binding]; other site 1052585001589 putative Zn2+ binding site [ion binding]; other site 1052585001590 AsnC family; Region: AsnC_trans_reg; pfam01037 1052585001591 DNA topoisomerase III; Provisional; Region: PRK07726 1052585001592 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1052585001593 active site 1052585001594 putative interdomain interaction site [polypeptide binding]; other site 1052585001595 putative metal-binding site [ion binding]; other site 1052585001596 putative nucleotide binding site [chemical binding]; other site 1052585001597 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1052585001598 domain I; other site 1052585001599 DNA binding groove [nucleotide binding] 1052585001600 phosphate binding site [ion binding]; other site 1052585001601 domain II; other site 1052585001602 domain III; other site 1052585001603 nucleotide binding site [chemical binding]; other site 1052585001604 catalytic site [active] 1052585001605 domain IV; other site 1052585001606 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1052585001607 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1052585001608 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1052585001609 CCC1-related family of proteins; Region: CCC1_like; cl00278 1052585001610 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052585001611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052585001612 metal binding site [ion binding]; metal-binding site 1052585001613 active site 1052585001614 I-site; other site 1052585001615 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1052585001616 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1052585001617 NodB motif; other site 1052585001618 putative active site [active] 1052585001619 putative catalytic site [active] 1052585001620 putative Zn binding site [ion binding]; other site 1052585001621 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1052585001622 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1052585001623 DXD motif; other site 1052585001624 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1052585001625 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1052585001626 Amino acid permease; Region: AA_permease_2; pfam13520 1052585001627 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1052585001628 nudix motif; other site 1052585001629 pyruvate oxidase; Provisional; Region: PRK08611 1052585001630 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1052585001631 PYR/PP interface [polypeptide binding]; other site 1052585001632 tetramer interface [polypeptide binding]; other site 1052585001633 dimer interface [polypeptide binding]; other site 1052585001634 TPP binding site [chemical binding]; other site 1052585001635 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1052585001636 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1052585001637 TPP-binding site [chemical binding]; other site 1052585001638 manganese transport protein MntH; Reviewed; Region: PRK00701 1052585001639 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1052585001640 Predicted membrane protein [Function unknown]; Region: COG2261 1052585001641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1052585001642 EcsC protein family; Region: EcsC; pfam12787 1052585001643 General stress protein [General function prediction only]; Region: GsiB; COG3729 1052585001644 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1052585001645 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052585001646 dimanganese center [ion binding]; other site 1052585001647 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1052585001648 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1052585001649 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052585001650 PAS domain; Region: PAS; smart00091 1052585001651 putative active site [active] 1052585001652 heme pocket [chemical binding]; other site 1052585001653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001654 ATP binding site [chemical binding]; other site 1052585001655 Mg2+ binding site [ion binding]; other site 1052585001656 G-X-G motif; other site 1052585001657 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052585001658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585001659 active site 1052585001660 phosphorylation site [posttranslational modification] 1052585001661 intermolecular recognition site; other site 1052585001662 dimerization interface [polypeptide binding]; other site 1052585001663 HTH domain; Region: HTH_11; cl17392 1052585001664 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1052585001665 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052585001666 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1052585001667 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052585001668 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052585001669 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1052585001670 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585001671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585001672 Walker A/P-loop; other site 1052585001673 ATP binding site [chemical binding]; other site 1052585001674 Q-loop/lid; other site 1052585001675 ABC transporter signature motif; other site 1052585001676 Walker B; other site 1052585001677 D-loop; other site 1052585001678 H-loop/switch region; other site 1052585001679 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1052585001680 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052585001681 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052585001682 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1052585001683 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1052585001684 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1052585001685 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1052585001686 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052585001687 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1052585001688 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052585001689 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052585001690 catalytic residues [active] 1052585001691 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1052585001692 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1052585001693 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1052585001694 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1052585001695 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1052585001696 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052585001697 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052585001698 helicase 45; Provisional; Region: PTZ00424 1052585001699 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052585001700 ATP binding site [chemical binding]; other site 1052585001701 Mg++ binding site [ion binding]; other site 1052585001702 motif III; other site 1052585001703 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585001704 nucleotide binding region [chemical binding]; other site 1052585001705 ATP-binding site [chemical binding]; other site 1052585001706 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1052585001707 Predicted membrane protein [Function unknown]; Region: COG3428 1052585001708 Bacterial PH domain; Region: DUF304; pfam03703 1052585001709 Bacterial PH domain; Region: DUF304; pfam03703 1052585001710 Bacterial PH domain; Region: DUF304; pfam03703 1052585001711 Rhomboid family; Region: Rhomboid; pfam01694 1052585001712 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1052585001713 alanine racemase; Region: alr; TIGR00492 1052585001714 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1052585001715 active site 1052585001716 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052585001717 dimer interface [polypeptide binding]; other site 1052585001718 substrate binding site [chemical binding]; other site 1052585001719 catalytic residues [active] 1052585001720 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1052585001721 ribbon-helix-helix domain containing protein; Region: PHA00617 1052585001722 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1052585001723 Rsbr N terminal; Region: Rsbr_N; pfam08678 1052585001724 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585001725 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585001726 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1052585001727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001728 ATP binding site [chemical binding]; other site 1052585001729 Mg2+ binding site [ion binding]; other site 1052585001730 G-X-G motif; other site 1052585001731 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1052585001732 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1052585001733 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1052585001734 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1052585001735 anti sigma factor interaction site; other site 1052585001736 regulatory phosphorylation site [posttranslational modification]; other site 1052585001737 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1052585001738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001739 ATP binding site [chemical binding]; other site 1052585001740 Mg2+ binding site [ion binding]; other site 1052585001741 G-X-G motif; other site 1052585001742 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1052585001743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585001744 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052585001745 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585001746 DNA binding residues [nucleotide binding] 1052585001747 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1052585001748 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1052585001749 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1052585001750 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1052585001751 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1052585001752 RNA binding site [nucleotide binding]; other site 1052585001753 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1052585001754 hypothetical protein; Provisional; Region: PRK04351 1052585001755 putative arabinose transporter; Provisional; Region: PRK03545 1052585001756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001757 putative substrate translocation pore; other site 1052585001758 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1052585001759 classical (c) SDRs; Region: SDR_c; cd05233 1052585001760 NAD(P) binding site [chemical binding]; other site 1052585001761 active site 1052585001762 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052585001763 dimerization domain swap beta strand [polypeptide binding]; other site 1052585001764 regulatory protein interface [polypeptide binding]; other site 1052585001765 regulatory phosphorylation site [posttranslational modification]; other site 1052585001766 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1052585001767 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1052585001768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585001769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585001770 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052585001771 Spore germination protein; Region: Spore_permease; cl17796 1052585001772 putative transporter; Provisional; Region: PRK11021 1052585001773 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052585001774 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585001775 putative DNA binding site [nucleotide binding]; other site 1052585001776 putative Zn2+ binding site [ion binding]; other site 1052585001777 AsnC family; Region: AsnC_trans_reg; pfam01037 1052585001778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585001779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585001780 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1052585001781 classical (c) SDRs; Region: SDR_c; cd05233 1052585001782 NAD(P) binding site [chemical binding]; other site 1052585001783 active site 1052585001784 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1052585001785 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1052585001786 putative NAD(P) binding site [chemical binding]; other site 1052585001787 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1052585001788 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052585001789 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052585001790 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1052585001791 AsnC family; Region: AsnC_trans_reg; pfam01037 1052585001792 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1052585001793 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1052585001794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001795 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585001796 putative substrate translocation pore; other site 1052585001797 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1052585001798 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1052585001799 inhibitor site; inhibition site 1052585001800 active site 1052585001801 dimer interface [polypeptide binding]; other site 1052585001802 catalytic residue [active] 1052585001803 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1052585001804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001805 putative substrate translocation pore; other site 1052585001806 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585001807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585001808 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585001809 dimerization interface [polypeptide binding]; other site 1052585001810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1052585001811 MOSC domain; Region: MOSC; pfam03473 1052585001812 3-alpha domain; Region: 3-alpha; pfam03475 1052585001813 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1052585001814 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1052585001815 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1052585001816 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1052585001817 putative di-iron ligands [ion binding]; other site 1052585001818 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1052585001819 DNA-binding site [nucleotide binding]; DNA binding site 1052585001820 RNA-binding motif; other site 1052585001821 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1052585001822 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1052585001823 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585001824 DNA-binding site [nucleotide binding]; DNA binding site 1052585001825 FCD domain; Region: FCD; pfam07729 1052585001826 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1052585001827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001828 putative substrate translocation pore; other site 1052585001829 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052585001830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585001831 non-specific DNA binding site [nucleotide binding]; other site 1052585001832 salt bridge; other site 1052585001833 sequence-specific DNA binding site [nucleotide binding]; other site 1052585001834 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585001835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585001836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1052585001837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1052585001838 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1052585001839 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1052585001840 CAAX protease self-immunity; Region: Abi; pfam02517 1052585001841 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052585001842 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1052585001843 NADP binding site [chemical binding]; other site 1052585001844 substrate binding site [chemical binding]; other site 1052585001845 active site 1052585001846 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052585001847 dimerization domain swap beta strand [polypeptide binding]; other site 1052585001848 regulatory protein interface [polypeptide binding]; other site 1052585001849 regulatory phosphorylation site [posttranslational modification]; other site 1052585001850 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1052585001851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585001852 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1052585001853 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1052585001854 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052585001855 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1052585001856 putative DNA binding site [nucleotide binding]; other site 1052585001857 putative Zn2+ binding site [ion binding]; other site 1052585001858 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052585001859 EamA-like transporter family; Region: EamA; pfam00892 1052585001860 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585001861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585001862 DNA-binding site [nucleotide binding]; DNA binding site 1052585001863 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585001864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585001865 homodimer interface [polypeptide binding]; other site 1052585001866 catalytic residue [active] 1052585001867 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1052585001868 putative active site [active] 1052585001869 putative catalytic site [active] 1052585001870 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1052585001871 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585001872 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585001873 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585001874 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585001875 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052585001876 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052585001877 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052585001878 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1052585001879 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585001880 dimerization interface [polypeptide binding]; other site 1052585001881 putative DNA binding site [nucleotide binding]; other site 1052585001882 putative Zn2+ binding site [ion binding]; other site 1052585001883 arsenical pump membrane protein; Provisional; Region: PRK15445 1052585001884 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1052585001885 transmembrane helices; other site 1052585001886 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1052585001887 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052585001888 active site 1052585001889 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1052585001890 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052585001891 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1052585001892 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052585001893 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1052585001894 NodB motif; other site 1052585001895 active site 1052585001896 catalytic site [active] 1052585001897 Zn binding site [ion binding]; other site 1052585001898 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 1052585001899 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585001900 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585001901 dimerization interface [polypeptide binding]; other site 1052585001902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585001903 dimer interface [polypeptide binding]; other site 1052585001904 phosphorylation site [posttranslational modification] 1052585001905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001906 ATP binding site [chemical binding]; other site 1052585001907 Mg2+ binding site [ion binding]; other site 1052585001908 G-X-G motif; other site 1052585001909 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585001910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585001911 active site 1052585001912 phosphorylation site [posttranslational modification] 1052585001913 intermolecular recognition site; other site 1052585001914 dimerization interface [polypeptide binding]; other site 1052585001915 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585001916 DNA binding site [nucleotide binding] 1052585001917 EamA-like transporter family; Region: EamA; pfam00892 1052585001918 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052585001919 EamA-like transporter family; Region: EamA; pfam00892 1052585001920 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585001921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585001922 DNA-binding site [nucleotide binding]; DNA binding site 1052585001923 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585001924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585001925 homodimer interface [polypeptide binding]; other site 1052585001926 catalytic residue [active] 1052585001927 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1052585001928 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585001929 dimerization interface [polypeptide binding]; other site 1052585001930 putative Zn2+ binding site [ion binding]; other site 1052585001931 putative DNA binding site [nucleotide binding]; other site 1052585001932 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1052585001933 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1052585001934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585001935 Histidine kinase; Region: HisKA_3; pfam07730 1052585001936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001937 ATP binding site [chemical binding]; other site 1052585001938 Mg2+ binding site [ion binding]; other site 1052585001939 G-X-G motif; other site 1052585001940 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585001941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585001942 active site 1052585001943 phosphorylation site [posttranslational modification] 1052585001944 intermolecular recognition site; other site 1052585001945 dimerization interface [polypeptide binding]; other site 1052585001946 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585001947 DNA binding residues [nucleotide binding] 1052585001948 dimerization interface [polypeptide binding]; other site 1052585001949 MMPL family; Region: MMPL; pfam03176 1052585001950 MMPL family; Region: MMPL; pfam03176 1052585001951 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 1052585001952 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 1052585001953 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1052585001954 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only]; Region: COG5152 1052585001955 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1052585001956 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052585001957 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052585001958 DNA binding residues [nucleotide binding] 1052585001959 drug binding residues [chemical binding]; other site 1052585001960 dimer interface [polypeptide binding]; other site 1052585001961 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1052585001962 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052585001963 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1052585001964 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052585001965 dimer interface [polypeptide binding]; other site 1052585001966 FMN binding site [chemical binding]; other site 1052585001967 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052585001968 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585001969 Zn binding site [ion binding]; other site 1052585001970 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052585001971 Zn binding site [ion binding]; other site 1052585001972 Predicted membrane protein [Function unknown]; Region: COG2259 1052585001973 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052585001974 catalytic residues [active] 1052585001975 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1052585001976 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1052585001977 putative dimer interface [polypeptide binding]; other site 1052585001978 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052585001979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585001980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585001981 DoxX-like family; Region: DoxX_2; pfam13564 1052585001982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585001983 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052585001984 Coenzyme A binding pocket [chemical binding]; other site 1052585001985 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585001986 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052585001987 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052585001988 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585001989 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585001990 DNA binding site [nucleotide binding] 1052585001991 domain linker motif; other site 1052585001992 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052585001993 dimerization interface [polypeptide binding]; other site 1052585001994 ligand binding site [chemical binding]; other site 1052585001995 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1052585001996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001997 putative substrate translocation pore; other site 1052585001998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001999 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052585002000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585002002 putative substrate translocation pore; other site 1052585002003 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585002004 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585002005 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052585002006 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052585002007 ABC transporter; Region: ABC_tran_2; pfam12848 1052585002008 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052585002009 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052585002010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1052585002011 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585002012 MarR family; Region: MarR; pfam01047 1052585002013 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1052585002014 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052585002015 dimer interface [polypeptide binding]; other site 1052585002016 FMN binding site [chemical binding]; other site 1052585002017 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585002018 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585002019 putative DNA binding site [nucleotide binding]; other site 1052585002020 putative Zn2+ binding site [ion binding]; other site 1052585002021 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1052585002022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585002023 non-specific DNA binding site [nucleotide binding]; other site 1052585002024 salt bridge; other site 1052585002025 sequence-specific DNA binding site [nucleotide binding]; other site 1052585002026 Cupin domain; Region: Cupin_2; pfam07883 1052585002027 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1052585002028 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1052585002029 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1052585002030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002031 putative substrate translocation pore; other site 1052585002032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1052585002033 Homeodomain-like domain; Region: HTH_23; pfam13384 1052585002034 putative transposase OrfB; Reviewed; Region: PHA02517 1052585002035 HTH-like domain; Region: HTH_21; pfam13276 1052585002036 Integrase core domain; Region: rve; pfam00665 1052585002037 Integrase core domain; Region: rve_3; pfam13683 1052585002038 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1052585002039 hypothetical protein; Provisional; Region: PRK10621 1052585002040 FCD domain; Region: FCD; pfam07729 1052585002041 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1052585002042 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585002043 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585002044 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1052585002045 active site 1052585002046 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1052585002047 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052585002048 homodimer interface [polypeptide binding]; other site 1052585002049 active site 1052585002050 TDP-binding site; other site 1052585002051 acceptor substrate-binding pocket; other site 1052585002052 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1052585002053 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1052585002054 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1052585002055 dimer interface [polypeptide binding]; other site 1052585002056 active site 1052585002057 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1052585002058 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1052585002059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585002060 Coenzyme A binding pocket [chemical binding]; other site 1052585002061 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1052585002062 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052585002063 Zn2+ binding site [ion binding]; other site 1052585002064 Mg2+ binding site [ion binding]; other site 1052585002065 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1052585002066 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1052585002067 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052585002068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002069 putative substrate translocation pore; other site 1052585002070 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1052585002071 active site 1052585002072 P-loop; other site 1052585002073 phosphorylation site [posttranslational modification] 1052585002074 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1052585002075 active site 1052585002076 methionine cluster; other site 1052585002077 phosphorylation site [posttranslational modification] 1052585002078 metal binding site [ion binding]; metal-binding site 1052585002079 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052585002080 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1052585002081 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1052585002082 beta-galactosidase; Region: BGL; TIGR03356 1052585002083 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052585002084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585002085 DNA-binding site [nucleotide binding]; DNA binding site 1052585002086 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1052585002087 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052585002088 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052585002089 nucleotide binding site [chemical binding]; other site 1052585002090 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1052585002091 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1052585002092 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1052585002093 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052585002094 dimanganese center [ion binding]; other site 1052585002095 thiamine-monophosphate kinase; Region: thiL; TIGR01379 1052585002096 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1052585002097 ATP binding site [chemical binding]; other site 1052585002098 dimerization interface [polypeptide binding]; other site 1052585002099 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1052585002100 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1052585002101 Glycoprotease family; Region: Peptidase_M22; pfam00814 1052585002102 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1052585002103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585002104 Coenzyme A binding pocket [chemical binding]; other site 1052585002105 UGMP family protein; Validated; Region: PRK09604 1052585002106 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1052585002107 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052585002108 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052585002109 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052585002110 ABC transporter; Region: ABC_tran_2; pfam12848 1052585002111 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052585002112 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1052585002113 trimer interface [polypeptide binding]; other site 1052585002114 dimer interface [polypeptide binding]; other site 1052585002115 putative active site [active] 1052585002116 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1052585002117 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1052585002118 CoA binding domain; Region: CoA_binding; pfam02629 1052585002119 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1052585002120 Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945 1052585002121 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1052585002122 CAAX protease self-immunity; Region: Abi; pfam02517 1052585002123 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1052585002124 oligomerisation interface [polypeptide binding]; other site 1052585002125 mobile loop; other site 1052585002126 roof hairpin; other site 1052585002127 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1052585002128 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1052585002129 ring oligomerisation interface [polypeptide binding]; other site 1052585002130 ATP/Mg binding site [chemical binding]; other site 1052585002131 stacking interactions; other site 1052585002132 hinge regions; other site 1052585002133 NB-ARC domain; Region: NB-ARC; pfam00931 1052585002134 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585002135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585002136 TPR motif; other site 1052585002137 TPR repeat; Region: TPR_11; pfam13414 1052585002138 binding surface 1052585002139 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052585002140 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1052585002141 inhibitor binding site; inhibition site 1052585002142 catalytic Zn binding site [ion binding]; other site 1052585002143 structural Zn binding site [ion binding]; other site 1052585002144 NADP binding site [chemical binding]; other site 1052585002145 tetramer interface [polypeptide binding]; other site 1052585002146 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1052585002147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002148 putative substrate translocation pore; other site 1052585002149 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052585002150 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1052585002151 putative substrate binding site [chemical binding]; other site 1052585002152 putative ATP binding site [chemical binding]; other site 1052585002153 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1052585002154 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1052585002155 Repair protein; Region: Repair_PSII; pfam04536 1052585002156 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1052585002157 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1052585002158 Double zinc ribbon; Region: DZR; pfam12773 1052585002159 Ion channel; Region: Ion_trans_2; pfam07885 1052585002160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002161 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052585002162 putative substrate translocation pore; other site 1052585002163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002164 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052585002165 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1052585002166 putative NAD(P) binding site [chemical binding]; other site 1052585002167 catalytic Zn binding site [ion binding]; other site 1052585002168 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1052585002169 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1052585002170 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052585002171 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052585002172 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1052585002173 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1052585002174 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052585002175 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1052585002176 MoxR-like ATPases [General function prediction only]; Region: COG0714 1052585002177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585002178 Walker A motif; other site 1052585002179 ATP binding site [chemical binding]; other site 1052585002180 Walker B motif; other site 1052585002181 arginine finger; other site 1052585002182 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1052585002183 Protein of unknown function DUF58; Region: DUF58; pfam01882 1052585002184 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1052585002185 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1052585002186 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1052585002187 GMP synthase; Reviewed; Region: guaA; PRK00074 1052585002188 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1052585002189 AMP/PPi binding site [chemical binding]; other site 1052585002190 candidate oxyanion hole; other site 1052585002191 catalytic triad [active] 1052585002192 potential glutamine specificity residues [chemical binding]; other site 1052585002193 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1052585002194 ATP Binding subdomain [chemical binding]; other site 1052585002195 Ligand Binding sites [chemical binding]; other site 1052585002196 Dimerization subdomain; other site 1052585002197 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1052585002198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1052585002199 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052585002200 NETI protein; Region: NETI; pfam14044 1052585002201 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1052585002202 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1052585002203 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1052585002204 ATP-grasp domain; Region: ATP-grasp; pfam02222 1052585002205 adenylosuccinate lyase; Provisional; Region: PRK07492 1052585002206 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1052585002207 tetramer interface [polypeptide binding]; other site 1052585002208 active site 1052585002209 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1052585002210 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1052585002211 ATP binding site [chemical binding]; other site 1052585002212 active site 1052585002213 substrate binding site [chemical binding]; other site 1052585002214 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1052585002215 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1052585002216 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1052585002217 putative active site [active] 1052585002218 catalytic triad [active] 1052585002219 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1052585002220 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1052585002221 dimerization interface [polypeptide binding]; other site 1052585002222 ATP binding site [chemical binding]; other site 1052585002223 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1052585002224 dimerization interface [polypeptide binding]; other site 1052585002225 ATP binding site [chemical binding]; other site 1052585002226 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1052585002227 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1052585002228 active site 1052585002229 tetramer interface [polypeptide binding]; other site 1052585002230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585002231 active site 1052585002232 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1052585002233 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1052585002234 dimerization interface [polypeptide binding]; other site 1052585002235 putative ATP binding site [chemical binding]; other site 1052585002236 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1052585002237 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1052585002238 active site 1052585002239 substrate binding site [chemical binding]; other site 1052585002240 cosubstrate binding site; other site 1052585002241 catalytic site [active] 1052585002242 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1052585002243 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1052585002244 purine monophosphate binding site [chemical binding]; other site 1052585002245 dimer interface [polypeptide binding]; other site 1052585002246 putative catalytic residues [active] 1052585002247 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1052585002248 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1052585002249 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1052585002250 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1052585002251 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1052585002252 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1052585002253 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052585002254 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585002255 putative DNA binding site [nucleotide binding]; other site 1052585002256 putative Zn2+ binding site [ion binding]; other site 1052585002257 AsnC family; Region: AsnC_trans_reg; pfam01037 1052585002258 putative transporter; Provisional; Region: PRK11021 1052585002259 Spore germination protein; Region: Spore_permease; cl17796 1052585002260 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1052585002261 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1052585002262 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052585002263 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1052585002264 active site 1052585002265 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052585002266 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1052585002267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1052585002268 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1052585002269 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1052585002270 active site 1052585002271 FMN binding site [chemical binding]; other site 1052585002272 substrate binding site [chemical binding]; other site 1052585002273 3Fe-4S cluster binding site [ion binding]; other site 1052585002274 PcrB family; Region: PcrB; pfam01884 1052585002275 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1052585002276 substrate binding site [chemical binding]; other site 1052585002277 putative active site [active] 1052585002278 dimer interface [polypeptide binding]; other site 1052585002279 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1052585002280 Part of AAA domain; Region: AAA_19; pfam13245 1052585002281 Family description; Region: UvrD_C_2; pfam13538 1052585002282 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1052585002283 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1052585002284 nucleotide binding pocket [chemical binding]; other site 1052585002285 K-X-D-G motif; other site 1052585002286 catalytic site [active] 1052585002287 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1052585002288 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1052585002289 Helix-hairpin-helix motif; Region: HHH; pfam00633 1052585002290 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1052585002291 Dimer interface [polypeptide binding]; other site 1052585002292 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1052585002293 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1052585002294 putative dimer interface [polypeptide binding]; other site 1052585002295 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1052585002296 putative dimer interface [polypeptide binding]; other site 1052585002297 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1052585002298 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1052585002299 active site 1052585002300 ATP binding site [chemical binding]; other site 1052585002301 substrate binding site [chemical binding]; other site 1052585002302 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1052585002303 MgtC family; Region: MgtC; pfam02308 1052585002304 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1052585002305 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1052585002306 Na binding site [ion binding]; other site 1052585002307 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1052585002308 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1052585002309 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1052585002310 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1052585002311 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1052585002312 GatB domain; Region: GatB_Yqey; pfam02637 1052585002313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585002314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585002315 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1052585002316 Protein export membrane protein; Region: SecD_SecF; cl14618 1052585002317 Protein export membrane protein; Region: SecD_SecF; cl14618 1052585002318 putative lipid kinase; Reviewed; Region: PRK13337 1052585002319 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1052585002320 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1052585002321 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1052585002322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585002323 S-adenosylmethionine binding site [chemical binding]; other site 1052585002324 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 1052585002325 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1052585002326 active site 1052585002327 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 1052585002328 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052585002329 Uncharacterized conserved protein [Function unknown]; Region: COG3586 1052585002330 hypothetical protein; Provisional; Region: PRK12378 1052585002331 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585002332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585002333 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1052585002334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585002335 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052585002336 NAD(P) binding site [chemical binding]; other site 1052585002337 active site 1052585002338 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1052585002339 CotJB protein; Region: CotJB; pfam12652 1052585002340 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052585002341 dimanganese center [ion binding]; other site 1052585002342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585002343 Coenzyme A binding pocket [chemical binding]; other site 1052585002344 Predicted integral membrane protein [Function unknown]; Region: COG5578 1052585002345 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052585002346 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585002347 dimerization interface [polypeptide binding]; other site 1052585002348 Histidine kinase; Region: His_kinase; pfam06580 1052585002349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585002350 ATP binding site [chemical binding]; other site 1052585002351 Mg2+ binding site [ion binding]; other site 1052585002352 G-X-G motif; other site 1052585002353 Response regulator receiver domain; Region: Response_reg; pfam00072 1052585002354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585002355 active site 1052585002356 phosphorylation site [posttranslational modification] 1052585002357 intermolecular recognition site; other site 1052585002358 dimerization interface [polypeptide binding]; other site 1052585002359 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585002360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585002361 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052585002362 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052585002363 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052585002364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585002365 dimer interface [polypeptide binding]; other site 1052585002366 conserved gate region; other site 1052585002367 putative PBP binding loops; other site 1052585002368 ABC-ATPase subunit interface; other site 1052585002369 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585002370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585002371 dimer interface [polypeptide binding]; other site 1052585002372 conserved gate region; other site 1052585002373 putative PBP binding loops; other site 1052585002374 ABC-ATPase subunit interface; other site 1052585002375 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1052585002376 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585002377 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585002378 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052585002379 active site 1052585002380 catalytic triad [active] 1052585002381 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 1052585002382 Predicted integral membrane protein [Function unknown]; Region: COG5578 1052585002383 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1052585002384 metal binding site [ion binding]; metal-binding site 1052585002385 active site 1052585002386 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1052585002387 metal binding site [ion binding]; metal-binding site 1052585002388 active site 1052585002389 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052585002390 active site 1052585002391 catalytic triad [active] 1052585002392 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1052585002393 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1052585002394 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1052585002395 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1052585002396 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052585002397 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052585002398 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052585002399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585002400 putative PBP binding loops; other site 1052585002401 dimer interface [polypeptide binding]; other site 1052585002402 ABC-ATPase subunit interface; other site 1052585002403 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585002404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585002405 dimer interface [polypeptide binding]; other site 1052585002406 conserved gate region; other site 1052585002407 putative PBP binding loops; other site 1052585002408 ABC-ATPase subunit interface; other site 1052585002409 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1052585002410 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1052585002411 NAD(P) binding site [chemical binding]; other site 1052585002412 LDH/MDH dimer interface [polypeptide binding]; other site 1052585002413 substrate binding site [chemical binding]; other site 1052585002414 Predicted membrane protein [Function unknown]; Region: COG2323 1052585002415 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1052585002416 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585002417 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1052585002418 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585002419 Uncharacterized small protein [Function unknown]; Region: COG5583 1052585002420 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1052585002421 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1052585002422 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052585002423 EamA-like transporter family; Region: EamA; pfam00892 1052585002424 EamA-like transporter family; Region: EamA; pfam00892 1052585002425 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585002426 MarR family; Region: MarR; pfam01047 1052585002427 hypothetical protein; Provisional; Region: PRK06847 1052585002428 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1052585002429 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1052585002430 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1052585002431 Restriction endonuclease; Region: Mrr_cat; pfam04471 1052585002432 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1052585002433 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1052585002434 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052585002435 Cytochrome P450; Region: p450; pfam00067 1052585002436 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1052585002437 Flavodoxin; Region: Flavodoxin_1; pfam00258 1052585002438 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1052585002439 FAD binding pocket [chemical binding]; other site 1052585002440 FAD binding motif [chemical binding]; other site 1052585002441 catalytic residues [active] 1052585002442 NAD binding pocket [chemical binding]; other site 1052585002443 phosphate binding motif [ion binding]; other site 1052585002444 beta-alpha-beta structure motif; other site 1052585002445 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052585002446 Sulfatase; Region: Sulfatase; pfam00884 1052585002447 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1052585002448 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1052585002449 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1052585002450 substrate binding site; other site 1052585002451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585002452 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052585002453 NAD(P) binding site [chemical binding]; other site 1052585002454 active site 1052585002455 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585002456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002457 putative substrate translocation pore; other site 1052585002458 amino acid transporter; Region: 2A0306; TIGR00909 1052585002459 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1052585002460 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1052585002461 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052585002462 NAD(P) binding site [chemical binding]; other site 1052585002463 catalytic residues [active] 1052585002464 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585002465 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1052585002466 dimer interface [polypeptide binding]; other site 1052585002467 putative CheW interface [polypeptide binding]; other site 1052585002468 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052585002469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585002470 Walker A/P-loop; other site 1052585002471 ATP binding site [chemical binding]; other site 1052585002472 Q-loop/lid; other site 1052585002473 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052585002474 ABC transporter signature motif; other site 1052585002475 Walker B; other site 1052585002476 D-loop; other site 1052585002477 ABC transporter; Region: ABC_tran_2; pfam12848 1052585002478 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052585002479 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1052585002480 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052585002481 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1052585002482 DNA binding residues [nucleotide binding] 1052585002483 putative dimer interface [polypeptide binding]; other site 1052585002484 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052585002485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002486 putative substrate translocation pore; other site 1052585002487 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1052585002488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585002489 Coenzyme A binding pocket [chemical binding]; other site 1052585002490 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052585002491 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052585002492 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052585002493 ABC transporter; Region: ABC_tran_2; pfam12848 1052585002494 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052585002495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1052585002496 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1052585002497 ATP binding site [chemical binding]; other site 1052585002498 putative Mg++ binding site [ion binding]; other site 1052585002499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585002500 nucleotide binding region [chemical binding]; other site 1052585002501 ATP-binding site [chemical binding]; other site 1052585002502 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052585002503 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052585002504 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1052585002505 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1052585002506 NAD(P) binding site [chemical binding]; other site 1052585002507 substrate binding site [chemical binding]; other site 1052585002508 dimer interface [polypeptide binding]; other site 1052585002509 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052585002510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002511 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1052585002512 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1052585002513 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052585002514 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052585002515 Walker A/P-loop; other site 1052585002516 ATP binding site [chemical binding]; other site 1052585002517 Q-loop/lid; other site 1052585002518 ABC transporter signature motif; other site 1052585002519 Walker B; other site 1052585002520 D-loop; other site 1052585002521 H-loop/switch region; other site 1052585002522 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052585002523 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585002524 ABC-ATPase subunit interface; other site 1052585002525 dimer interface [polypeptide binding]; other site 1052585002526 putative PBP binding regions; other site 1052585002527 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052585002528 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585002529 ABC-ATPase subunit interface; other site 1052585002530 dimer interface [polypeptide binding]; other site 1052585002531 putative PBP binding regions; other site 1052585002532 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1052585002533 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052585002534 siderophore binding site; other site 1052585002535 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1052585002536 Heat induced stress protein YflT; Region: YflT; pfam11181 1052585002537 Amb_all domain; Region: Amb_all; smart00656 1052585002538 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1052585002539 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1052585002540 transmembrane helices; other site 1052585002541 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052585002542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585002543 ATP binding site [chemical binding]; other site 1052585002544 Mg2+ binding site [ion binding]; other site 1052585002545 G-X-G motif; other site 1052585002546 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052585002547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585002548 active site 1052585002549 phosphorylation site [posttranslational modification] 1052585002550 intermolecular recognition site; other site 1052585002551 dimerization interface [polypeptide binding]; other site 1052585002552 Transcriptional regulator; Region: CitT; pfam12431 1052585002553 HTH domain; Region: HTH_11; cl17392 1052585002554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1052585002555 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1052585002556 Citrate transporter; Region: CitMHS; pfam03600 1052585002557 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052585002558 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1052585002559 active site 1052585002560 dimer interface [polypeptide binding]; other site 1052585002561 acylphosphatase; Provisional; Region: PRK14420 1052585002562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1052585002563 MOSC domain; Region: MOSC; pfam03473 1052585002564 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1052585002565 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1052585002566 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1052585002567 active site 1052585002568 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1052585002569 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052585002570 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585002571 active site turn [active] 1052585002572 phosphorylation site [posttranslational modification] 1052585002573 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052585002574 Sulfatase; Region: Sulfatase; pfam00884 1052585002575 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1052585002576 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052585002577 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1052585002578 Spore germination protein; Region: Spore_permease; cl17796 1052585002579 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052585002580 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1052585002581 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585002582 active site turn [active] 1052585002583 phosphorylation site [posttranslational modification] 1052585002584 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052585002585 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052585002586 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052585002587 active site 1052585002588 catalytic site [active] 1052585002589 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1052585002590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585002591 DNA-binding site [nucleotide binding]; DNA binding site 1052585002592 UTRA domain; Region: UTRA; pfam07702 1052585002593 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1052585002594 dimer interface [polypeptide binding]; other site 1052585002595 FMN binding site [chemical binding]; other site 1052585002596 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1052585002597 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1052585002598 active site 1052585002599 metal binding site [ion binding]; metal-binding site 1052585002600 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052585002601 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 1052585002602 active site 1052585002603 metal binding site [ion binding]; metal-binding site 1052585002604 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052585002605 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1052585002606 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1052585002607 proposed catalytic triad [active] 1052585002608 conserved cys residue [active] 1052585002609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585002611 putative substrate translocation pore; other site 1052585002612 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1052585002613 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052585002614 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1052585002615 active site 1052585002616 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1052585002617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002618 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585002619 putative substrate translocation pore; other site 1052585002620 calcium/proton exchanger (cax); Region: cax; TIGR00378 1052585002621 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1052585002622 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1052585002623 YfkD-like protein; Region: YfkD; pfam14167 1052585002624 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1052585002625 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1052585002626 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1052585002627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585002628 FeS/SAM binding site; other site 1052585002629 YfkB-like domain; Region: YfkB; pfam08756 1052585002630 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1052585002631 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1052585002632 NodB motif; other site 1052585002633 active site 1052585002634 catalytic site [active] 1052585002635 Cd binding site [ion binding]; other site 1052585002636 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1052585002637 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1052585002638 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1052585002639 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1052585002640 oligomer interface [polypeptide binding]; other site 1052585002641 metal binding site [ion binding]; metal-binding site 1052585002642 metal binding site [ion binding]; metal-binding site 1052585002643 putative Cl binding site [ion binding]; other site 1052585002644 aspartate ring; other site 1052585002645 basic sphincter; other site 1052585002646 hydrophobic gate; other site 1052585002647 periplasmic entrance; other site 1052585002648 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1052585002649 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052585002650 minor groove reading motif; other site 1052585002651 helix-hairpin-helix signature motif; other site 1052585002652 substrate binding pocket [chemical binding]; other site 1052585002653 active site 1052585002654 TRAM domain; Region: TRAM; pfam01938 1052585002655 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1052585002656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585002657 S-adenosylmethionine binding site [chemical binding]; other site 1052585002658 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1052585002659 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1052585002660 FMN binding site [chemical binding]; other site 1052585002661 active site 1052585002662 catalytic residues [active] 1052585002663 substrate binding site [chemical binding]; other site 1052585002664 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052585002665 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052585002666 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1052585002667 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052585002668 tetramer interface [polypeptide binding]; other site 1052585002669 TPP-binding site [chemical binding]; other site 1052585002670 heterodimer interface [polypeptide binding]; other site 1052585002671 phosphorylation loop region [posttranslational modification] 1052585002672 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052585002673 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052585002674 alpha subunit interface [polypeptide binding]; other site 1052585002675 TPP binding site [chemical binding]; other site 1052585002676 heterodimer interface [polypeptide binding]; other site 1052585002677 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052585002678 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1052585002679 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052585002680 E3 interaction surface; other site 1052585002681 lipoyl attachment site [posttranslational modification]; other site 1052585002682 e3 binding domain; Region: E3_binding; pfam02817 1052585002683 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1052585002684 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1052585002685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585002686 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052585002687 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1052585002688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585002689 Walker A motif; other site 1052585002690 ATP binding site [chemical binding]; other site 1052585002691 Walker B motif; other site 1052585002692 arginine finger; other site 1052585002693 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1052585002694 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 1052585002695 hypothetical protein; Provisional; Region: PRK02237 1052585002696 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1052585002697 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1052585002698 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1052585002699 NAD binding site [chemical binding]; other site 1052585002700 sugar binding site [chemical binding]; other site 1052585002701 divalent metal binding site [ion binding]; other site 1052585002702 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585002703 dimer interface [polypeptide binding]; other site 1052585002704 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052585002705 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1052585002706 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1052585002707 putative active site [active] 1052585002708 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1052585002709 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1052585002710 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585002711 active site turn [active] 1052585002712 phosphorylation site [posttranslational modification] 1052585002713 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585002714 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052585002715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585002716 Walker A/P-loop; other site 1052585002717 ATP binding site [chemical binding]; other site 1052585002718 Q-loop/lid; other site 1052585002719 ABC transporter signature motif; other site 1052585002720 Walker B; other site 1052585002721 D-loop; other site 1052585002722 H-loop/switch region; other site 1052585002723 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585002724 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052585002725 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1052585002726 Walker A/P-loop; other site 1052585002727 ATP binding site [chemical binding]; other site 1052585002728 Q-loop/lid; other site 1052585002729 ABC transporter signature motif; other site 1052585002730 Walker B; other site 1052585002731 D-loop; other site 1052585002732 H-loop/switch region; other site 1052585002733 Predicted membrane protein [Function unknown]; Region: COG2259 1052585002734 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1052585002735 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1052585002736 putative metal binding site [ion binding]; other site 1052585002737 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1052585002738 active site 1052585002739 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052585002740 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052585002741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585002742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585002743 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052585002744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002745 putative substrate translocation pore; other site 1052585002746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002747 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052585002748 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1052585002749 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585002750 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052585002751 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052585002752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585002753 Histidine kinase; Region: HisKA_3; pfam07730 1052585002754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585002755 ATP binding site [chemical binding]; other site 1052585002756 Mg2+ binding site [ion binding]; other site 1052585002757 G-X-G motif; other site 1052585002758 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585002759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585002760 active site 1052585002761 phosphorylation site [posttranslational modification] 1052585002762 intermolecular recognition site; other site 1052585002763 dimerization interface [polypeptide binding]; other site 1052585002764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585002765 DNA binding residues [nucleotide binding] 1052585002766 dimerization interface [polypeptide binding]; other site 1052585002767 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585002768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585002769 Walker A/P-loop; other site 1052585002770 ATP binding site [chemical binding]; other site 1052585002771 Q-loop/lid; other site 1052585002772 ABC transporter signature motif; other site 1052585002773 Walker B; other site 1052585002774 D-loop; other site 1052585002775 H-loop/switch region; other site 1052585002776 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1052585002777 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1052585002778 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052585002779 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1052585002780 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052585002781 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052585002782 Predicted transcriptional regulators [Transcription]; Region: COG1695 1052585002783 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1052585002784 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1052585002785 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1052585002786 Lipase (class 2); Region: Lipase_2; pfam01674 1052585002787 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1052585002788 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052585002789 metal-dependent hydrolase; Provisional; Region: PRK13291 1052585002790 DinB superfamily; Region: DinB_2; pfam12867 1052585002791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002792 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585002793 putative substrate translocation pore; other site 1052585002794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002795 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585002796 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585002797 putative Zn2+ binding site [ion binding]; other site 1052585002798 putative DNA binding site [nucleotide binding]; other site 1052585002799 Predicted integral membrane protein [Function unknown]; Region: COG0392 1052585002800 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1052585002801 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1052585002802 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1052585002803 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052585002804 siderophore binding site; other site 1052585002805 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052585002806 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585002807 ABC-ATPase subunit interface; other site 1052585002808 dimer interface [polypeptide binding]; other site 1052585002809 putative PBP binding regions; other site 1052585002810 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052585002811 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585002812 ABC-ATPase subunit interface; other site 1052585002813 dimer interface [polypeptide binding]; other site 1052585002814 putative PBP binding regions; other site 1052585002815 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1052585002816 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1052585002817 putative FMN binding site [chemical binding]; other site 1052585002818 YfhD-like protein; Region: YfhD; pfam14151 1052585002819 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1052585002820 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1052585002821 putative NAD(P) binding site [chemical binding]; other site 1052585002822 putative active site [active] 1052585002823 recombination regulator RecX; Provisional; Region: recX; PRK14135 1052585002824 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1052585002825 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052585002826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002827 putative substrate translocation pore; other site 1052585002828 Small acid-soluble spore protein K family; Region: SspK; pfam08176 1052585002829 WVELL protein; Region: WVELL; pfam14043 1052585002830 Bacterial SH3 domain; Region: SH3_3; pfam08239 1052585002831 Predicted integral membrane protein [Function unknown]; Region: COG5658 1052585002832 SdpI/YhfL protein family; Region: SdpI; pfam13630 1052585002833 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052585002834 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052585002835 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1052585002836 catalytic site [active] 1052585002837 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1052585002838 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052585002839 Ligand binding site; other site 1052585002840 Putative Catalytic site; other site 1052585002841 DXD motif; other site 1052585002842 Predicted membrane protein [Function unknown]; Region: COG4485 1052585002843 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1052585002844 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1052585002845 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052585002846 minor groove reading motif; other site 1052585002847 helix-hairpin-helix signature motif; other site 1052585002848 substrate binding pocket [chemical binding]; other site 1052585002849 active site 1052585002850 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1052585002851 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1052585002852 DNA binding and oxoG recognition site [nucleotide binding] 1052585002853 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1052585002854 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1052585002855 putative NAD(P) binding site [chemical binding]; other site 1052585002856 active site 1052585002857 YgaB-like protein; Region: YgaB; pfam14182 1052585002858 hypothetical protein; Provisional; Region: PRK13662 1052585002859 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585002860 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052585002861 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1052585002862 Walker A/P-loop; other site 1052585002863 ATP binding site [chemical binding]; other site 1052585002864 Q-loop/lid; other site 1052585002865 ABC transporter signature motif; other site 1052585002866 Walker B; other site 1052585002867 D-loop; other site 1052585002868 H-loop/switch region; other site 1052585002869 Predicted membrane protein [Function unknown]; Region: COG4129 1052585002870 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1052585002871 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1052585002872 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585002873 inhibitor-cofactor binding pocket; inhibition site 1052585002874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585002875 catalytic residue [active] 1052585002876 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1052585002877 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1052585002878 catalytic triad [active] 1052585002879 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052585002880 metal binding site 2 [ion binding]; metal-binding site 1052585002881 putative DNA binding helix; other site 1052585002882 metal binding site 1 [ion binding]; metal-binding site 1052585002883 dimer interface [polypeptide binding]; other site 1052585002884 structural Zn2+ binding site [ion binding]; other site 1052585002885 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1052585002886 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1052585002887 SpoOM protein; Region: Spo0M; pfam07070 1052585002888 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1052585002889 active site pocket [active] 1052585002890 oxyanion hole [active] 1052585002891 catalytic triad [active] 1052585002892 active site nucleophile [active] 1052585002893 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1052585002894 ThiC-associated domain; Region: ThiC-associated; pfam13667 1052585002895 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1052585002896 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1052585002897 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1052585002898 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1052585002899 tetramer interface [polypeptide binding]; other site 1052585002900 heme binding pocket [chemical binding]; other site 1052585002901 NADPH binding site [chemical binding]; other site 1052585002902 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1052585002903 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1052585002904 Walker A/P-loop; other site 1052585002905 ATP binding site [chemical binding]; other site 1052585002906 Q-loop/lid; other site 1052585002907 ABC transporter signature motif; other site 1052585002908 Walker B; other site 1052585002909 D-loop; other site 1052585002910 H-loop/switch region; other site 1052585002911 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1052585002912 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052585002913 substrate binding pocket [chemical binding]; other site 1052585002914 membrane-bound complex binding site; other site 1052585002915 hinge residues; other site 1052585002916 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1052585002917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585002918 dimer interface [polypeptide binding]; other site 1052585002919 conserved gate region; other site 1052585002920 putative PBP binding loops; other site 1052585002921 ABC-ATPase subunit interface; other site 1052585002922 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1052585002923 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1052585002924 active site 1052585002925 dimer interface [polypeptide binding]; other site 1052585002926 non-prolyl cis peptide bond; other site 1052585002927 insertion regions; other site 1052585002928 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1052585002929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585002930 non-specific DNA binding site [nucleotide binding]; other site 1052585002931 salt bridge; other site 1052585002932 sequence-specific DNA binding site [nucleotide binding]; other site 1052585002933 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1052585002934 epoxyqueuosine reductase; Region: TIGR00276 1052585002935 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1052585002936 Putative amidase domain; Region: Amidase_6; pfam12671 1052585002937 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1052585002938 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1052585002939 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1052585002940 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1052585002941 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1052585002942 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1052585002943 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1052585002944 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1052585002945 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585002946 MarR family; Region: MarR; pfam01047 1052585002947 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1052585002948 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052585002949 carboxyltransferase (CT) interaction site; other site 1052585002950 biotinylation site [posttranslational modification]; other site 1052585002951 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052585002952 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1052585002953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002954 putative substrate translocation pore; other site 1052585002955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002956 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1052585002957 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052585002958 Predicted transcriptional regulators [Transcription]; Region: COG1725 1052585002959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585002960 DNA-binding site [nucleotide binding]; DNA binding site 1052585002961 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052585002962 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052585002963 Walker A/P-loop; other site 1052585002964 ATP binding site [chemical binding]; other site 1052585002965 Q-loop/lid; other site 1052585002966 ABC transporter signature motif; other site 1052585002967 Walker B; other site 1052585002968 D-loop; other site 1052585002969 H-loop/switch region; other site 1052585002970 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585002971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585002972 Walker A/P-loop; other site 1052585002973 ATP binding site [chemical binding]; other site 1052585002974 Q-loop/lid; other site 1052585002975 ABC transporter signature motif; other site 1052585002976 Walker B; other site 1052585002977 D-loop; other site 1052585002978 H-loop/switch region; other site 1052585002979 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1052585002980 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052585002981 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1052585002982 DNA-binding site [nucleotide binding]; DNA binding site 1052585002983 RNA-binding motif; other site 1052585002984 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1052585002985 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1052585002986 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1052585002987 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052585002988 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052585002989 metal binding site [ion binding]; metal-binding site 1052585002990 active site 1052585002991 I-site; other site 1052585002992 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1052585002993 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052585002994 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1052585002995 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052585002996 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1052585002997 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1052585002998 generic binding surface II; other site 1052585002999 generic binding surface I; other site 1052585003000 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1052585003001 generic binding surface II; other site 1052585003002 generic binding surface I; other site 1052585003003 Staphylococcal nuclease homologues; Region: SNc; smart00318 1052585003004 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1052585003005 Catalytic site; other site 1052585003006 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1052585003007 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1052585003008 putative active site [active] 1052585003009 putative metal binding site [ion binding]; other site 1052585003010 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052585003011 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1052585003012 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1052585003013 active site 1052585003014 catalytic site [active] 1052585003015 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1052585003016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585003017 RNA binding surface [nucleotide binding]; other site 1052585003018 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052585003019 active site 1052585003020 FOG: CBS domain [General function prediction only]; Region: COG0517 1052585003021 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1052585003022 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1052585003023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585003024 motif II; other site 1052585003025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585003026 Coenzyme A binding pocket [chemical binding]; other site 1052585003027 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1052585003028 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1052585003029 putative active site [active] 1052585003030 catalytic triad [active] 1052585003031 putative dimer interface [polypeptide binding]; other site 1052585003032 Predicted permeases [General function prediction only]; Region: COG0679 1052585003033 aminotransferase; Validated; Region: PRK07678 1052585003034 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585003035 inhibitor-cofactor binding pocket; inhibition site 1052585003036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003037 catalytic residue [active] 1052585003038 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1052585003039 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1052585003040 amphipathic channel; other site 1052585003041 Asn-Pro-Ala signature motifs; other site 1052585003042 glycerol kinase; Provisional; Region: glpK; PRK00047 1052585003043 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1052585003044 N- and C-terminal domain interface [polypeptide binding]; other site 1052585003045 active site 1052585003046 MgATP binding site [chemical binding]; other site 1052585003047 catalytic site [active] 1052585003048 metal binding site [ion binding]; metal-binding site 1052585003049 glycerol binding site [chemical binding]; other site 1052585003050 homotetramer interface [polypeptide binding]; other site 1052585003051 homodimer interface [polypeptide binding]; other site 1052585003052 FBP binding site [chemical binding]; other site 1052585003053 protein IIAGlc interface [polypeptide binding]; other site 1052585003054 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1052585003055 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1052585003056 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1052585003057 active site 1052585003058 substrate binding site [chemical binding]; other site 1052585003059 metal binding site [ion binding]; metal-binding site 1052585003060 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1052585003061 GAF domain; Region: GAF; pfam01590 1052585003062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585003063 Histidine kinase; Region: HisKA_3; pfam07730 1052585003064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585003065 ATP binding site [chemical binding]; other site 1052585003066 Mg2+ binding site [ion binding]; other site 1052585003067 G-X-G motif; other site 1052585003068 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585003069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585003070 active site 1052585003071 phosphorylation site [posttranslational modification] 1052585003072 intermolecular recognition site; other site 1052585003073 dimerization interface [polypeptide binding]; other site 1052585003074 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585003075 DNA binding residues [nucleotide binding] 1052585003076 dimerization interface [polypeptide binding]; other site 1052585003077 Predicted flavoprotein [General function prediction only]; Region: COG0431 1052585003078 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052585003079 YhdB-like protein; Region: YhdB; pfam14148 1052585003080 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1052585003081 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585003082 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585003083 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585003084 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1052585003085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585003086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585003087 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052585003088 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052585003089 Transcriptional regulator; Region: Rrf2; cl17282 1052585003090 Rrf2 family protein; Region: rrf2_super; TIGR00738 1052585003091 Conserved TM helix; Region: TM_helix; pfam05552 1052585003092 Conserved TM helix; Region: TM_helix; pfam05552 1052585003093 Conserved TM helix; Region: TM_helix; pfam05552 1052585003094 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1052585003095 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1052585003096 dimer interface [polypeptide binding]; other site 1052585003097 active site 1052585003098 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585003099 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585003100 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585003101 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052585003102 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052585003103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585003104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585003105 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585003106 dimerization interface [polypeptide binding]; other site 1052585003107 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1052585003108 dimer interface [polypeptide binding]; other site 1052585003109 Citrate synthase; Region: Citrate_synt; pfam00285 1052585003110 active site 1052585003111 citrylCoA binding site [chemical binding]; other site 1052585003112 oxalacetate/citrate binding site [chemical binding]; other site 1052585003113 coenzyme A binding site [chemical binding]; other site 1052585003114 catalytic triad [active] 1052585003115 short chain dehydrogenase; Provisional; Region: PRK06701 1052585003116 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052585003117 NAD binding site [chemical binding]; other site 1052585003118 metal binding site [ion binding]; metal-binding site 1052585003119 active site 1052585003120 amino acid transporter; Region: 2A0306; TIGR00909 1052585003121 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1052585003122 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1052585003123 Na2 binding site [ion binding]; other site 1052585003124 putative substrate binding site 1 [chemical binding]; other site 1052585003125 Na binding site 1 [ion binding]; other site 1052585003126 putative substrate binding site 2 [chemical binding]; other site 1052585003127 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585003128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585003129 DNA-binding site [nucleotide binding]; DNA binding site 1052585003130 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585003131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003132 homodimer interface [polypeptide binding]; other site 1052585003133 catalytic residue [active] 1052585003134 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052585003135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585003136 Coenzyme A binding pocket [chemical binding]; other site 1052585003137 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1052585003138 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1052585003139 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1052585003140 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585003141 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585003142 DNA binding residues [nucleotide binding] 1052585003143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585003144 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052585003145 active site 1052585003146 catalytic tetrad [active] 1052585003147 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1052585003148 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1052585003149 putative acyl-acceptor binding pocket; other site 1052585003150 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1052585003151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1052585003152 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052585003153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003154 NAD(P) binding site [chemical binding]; other site 1052585003155 active site 1052585003156 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052585003157 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052585003158 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052585003159 Transporter associated domain; Region: CorC_HlyC; smart01091 1052585003160 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1052585003161 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052585003162 DNA binding residues [nucleotide binding] 1052585003163 putative dimer interface [polypeptide binding]; other site 1052585003164 aspartate aminotransferase; Provisional; Region: PRK06836 1052585003165 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585003166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003167 homodimer interface [polypeptide binding]; other site 1052585003168 catalytic residue [active] 1052585003169 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052585003170 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052585003171 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052585003172 Transporter associated domain; Region: CorC_HlyC; smart01091 1052585003173 camphor resistance protein CrcB; Provisional; Region: PRK14213 1052585003174 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1052585003175 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1052585003176 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1052585003177 active site 1052585003178 catalytic site [active] 1052585003179 metal binding site [ion binding]; metal-binding site 1052585003180 dimer interface [polypeptide binding]; other site 1052585003181 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1052585003182 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1052585003183 NAD-dependent deacetylase; Provisional; Region: PRK00481 1052585003184 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1052585003185 NAD+ binding site [chemical binding]; other site 1052585003186 substrate binding site [chemical binding]; other site 1052585003187 Zn binding site [ion binding]; other site 1052585003188 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052585003189 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1052585003190 NodB motif; other site 1052585003191 active site 1052585003192 catalytic site [active] 1052585003193 Zn binding site [ion binding]; other site 1052585003194 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1052585003195 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1052585003196 homodimer interface [polypeptide binding]; other site 1052585003197 substrate-cofactor binding pocket; other site 1052585003198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003199 catalytic residue [active] 1052585003200 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1052585003201 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1052585003202 Ligand Binding Site [chemical binding]; other site 1052585003203 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585003204 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052585003205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585003206 Walker A/P-loop; other site 1052585003207 ATP binding site [chemical binding]; other site 1052585003208 Q-loop/lid; other site 1052585003209 ABC transporter signature motif; other site 1052585003210 Walker B; other site 1052585003211 D-loop; other site 1052585003212 H-loop/switch region; other site 1052585003213 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585003214 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052585003215 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1052585003216 Walker A/P-loop; other site 1052585003217 ATP binding site [chemical binding]; other site 1052585003218 Q-loop/lid; other site 1052585003219 ABC transporter signature motif; other site 1052585003220 Walker B; other site 1052585003221 D-loop; other site 1052585003222 H-loop/switch region; other site 1052585003223 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1052585003224 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052585003225 NAD binding site [chemical binding]; other site 1052585003226 substrate binding site [chemical binding]; other site 1052585003227 putative active site [active] 1052585003228 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052585003229 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052585003230 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052585003231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1052585003232 hypothetical protein; Provisional; Region: PRK13676 1052585003233 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1052585003234 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1052585003235 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1052585003236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585003237 active site 1052585003238 motif I; other site 1052585003239 motif II; other site 1052585003240 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1052585003241 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1052585003242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585003243 FeS/SAM binding site; other site 1052585003244 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1052585003245 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1052585003246 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1052585003247 TrkA-C domain; Region: TrkA_C; pfam02080 1052585003248 enoyl-CoA hydratase; Provisional; Region: PRK07659 1052585003249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585003250 substrate binding site [chemical binding]; other site 1052585003251 oxyanion hole (OAH) forming residues; other site 1052585003252 trimer interface [polypeptide binding]; other site 1052585003253 YhzD-like protein; Region: YhzD; pfam14120 1052585003254 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1052585003255 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1052585003256 Walker A/P-loop; other site 1052585003257 ATP binding site [chemical binding]; other site 1052585003258 Q-loop/lid; other site 1052585003259 ABC transporter signature motif; other site 1052585003260 Walker B; other site 1052585003261 D-loop; other site 1052585003262 H-loop/switch region; other site 1052585003263 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1052585003264 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052585003265 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1052585003266 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1052585003267 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1052585003268 active site 1052585003269 metal binding site [ion binding]; metal-binding site 1052585003270 DNA binding site [nucleotide binding] 1052585003271 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1052585003272 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1052585003273 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1052585003274 generic binding surface II; other site 1052585003275 generic binding surface I; other site 1052585003276 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052585003277 Zn2+ binding site [ion binding]; other site 1052585003278 Mg2+ binding site [ion binding]; other site 1052585003279 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1052585003280 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1052585003281 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 1052585003282 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1052585003283 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1052585003284 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1052585003285 transcriptional regulator Hpr; Provisional; Region: PRK13777 1052585003286 MarR family; Region: MarR; pfam01047 1052585003287 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1052585003288 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1052585003289 homodimer interface [polypeptide binding]; other site 1052585003290 substrate-cofactor binding pocket; other site 1052585003291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003292 catalytic residue [active] 1052585003293 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1052585003294 HIT family signature motif; other site 1052585003295 catalytic residue [active] 1052585003296 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052585003297 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052585003298 Walker A/P-loop; other site 1052585003299 ATP binding site [chemical binding]; other site 1052585003300 Q-loop/lid; other site 1052585003301 ABC transporter signature motif; other site 1052585003302 Walker B; other site 1052585003303 D-loop; other site 1052585003304 H-loop/switch region; other site 1052585003305 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1052585003306 EcsC protein family; Region: EcsC; pfam12787 1052585003307 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052585003308 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1052585003309 metal binding site [ion binding]; metal-binding site 1052585003310 dimer interface [polypeptide binding]; other site 1052585003311 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1052585003312 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1052585003313 Transglycosylase; Region: Transgly; pfam00912 1052585003314 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052585003315 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1052585003316 substrate binding site [chemical binding]; other site 1052585003317 active site 1052585003318 ferrochelatase; Provisional; Region: PRK12435 1052585003319 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1052585003320 C-terminal domain interface [polypeptide binding]; other site 1052585003321 active site 1052585003322 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1052585003323 active site 1052585003324 N-terminal domain interface [polypeptide binding]; other site 1052585003325 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1052585003326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052585003327 SEA domain; Region: SEA; cl02507 1052585003328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585003329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585003330 Predicted membrane protein [Function unknown]; Region: COG1511 1052585003331 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1052585003332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585003333 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1052585003334 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1052585003335 dimer interface [polypeptide binding]; other site 1052585003336 active site 1052585003337 CoA binding pocket [chemical binding]; other site 1052585003338 Predicted membrane protein [Function unknown]; Region: COG4377 1052585003339 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052585003340 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1052585003341 putative oligomer interface [polypeptide binding]; other site 1052585003342 putative active site [active] 1052585003343 metal binding site [ion binding]; metal-binding site 1052585003344 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1052585003345 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052585003346 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052585003347 YhfH-like protein; Region: YhfH; pfam14149 1052585003348 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1052585003349 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1052585003350 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1052585003351 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1052585003352 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1052585003353 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052585003354 NAD(P) binding site [chemical binding]; other site 1052585003355 putative active site [active] 1052585003356 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1052585003357 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1052585003358 acyl-activating enzyme (AAE) consensus motif; other site 1052585003359 putative AMP binding site [chemical binding]; other site 1052585003360 putative active site [active] 1052585003361 putative CoA binding site [chemical binding]; other site 1052585003362 Peptidase family M48; Region: Peptidase_M48; pfam01435 1052585003363 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052585003364 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052585003365 active site 1052585003366 catalytic residues [active] 1052585003367 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052585003368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585003369 Coenzyme A binding pocket [chemical binding]; other site 1052585003370 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1052585003371 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1052585003372 putative NADP binding site [chemical binding]; other site 1052585003373 putative dimer interface [polypeptide binding]; other site 1052585003374 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1052585003375 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052585003376 siderophore binding site; other site 1052585003377 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052585003378 catalytic core [active] 1052585003379 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1052585003380 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1052585003381 dimer interface [polypeptide binding]; other site 1052585003382 active site 1052585003383 acyl-CoA synthetase; Validated; Region: PRK07638 1052585003384 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052585003385 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1052585003386 acyl-activating enzyme (AAE) consensus motif; other site 1052585003387 acyl-activating enzyme (AAE) consensus motif; other site 1052585003388 AMP binding site [chemical binding]; other site 1052585003389 active site 1052585003390 CoA binding site [chemical binding]; other site 1052585003391 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1052585003392 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1052585003393 heme-binding site [chemical binding]; other site 1052585003394 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 1052585003395 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585003396 Active site flap [active] 1052585003397 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585003398 dimer interface [polypeptide binding]; other site 1052585003399 putative CheW interface [polypeptide binding]; other site 1052585003400 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1052585003401 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1052585003402 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1052585003403 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1052585003404 [2Fe-2S] cluster binding site [ion binding]; other site 1052585003405 short chain dehydrogenase; Provisional; Region: PRK06701 1052585003406 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052585003407 NAD binding site [chemical binding]; other site 1052585003408 metal binding site [ion binding]; metal-binding site 1052585003409 active site 1052585003410 IDEAL domain; Region: IDEAL; pfam08858 1052585003411 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1052585003412 oxidoreductase; Provisional; Region: PRK07985 1052585003413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003414 NAD(P) binding site [chemical binding]; other site 1052585003415 active site 1052585003416 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1052585003417 Na binding site [ion binding]; other site 1052585003418 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1052585003419 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1052585003420 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052585003421 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052585003422 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052585003423 Catalytic site [active] 1052585003424 hypothetical protein; Provisional; Region: PRK08244 1052585003425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585003426 hypothetical protein; Provisional; Region: PRK07236 1052585003427 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1052585003428 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585003429 MarR family; Region: MarR; pfam01047 1052585003430 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1052585003431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585003432 putative substrate translocation pore; other site 1052585003433 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585003434 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052585003435 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052585003436 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1052585003437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585003438 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1052585003439 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1052585003440 inhibitor-cofactor binding pocket; inhibition site 1052585003441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003442 catalytic residue [active] 1052585003443 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585003444 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585003445 DNA binding site [nucleotide binding] 1052585003446 domain linker motif; other site 1052585003447 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1052585003448 putative dimerization interface [polypeptide binding]; other site 1052585003449 putative ligand binding site [chemical binding]; other site 1052585003450 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1052585003451 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1052585003452 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1052585003453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585003454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585003455 putative substrate translocation pore; other site 1052585003456 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1052585003457 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1052585003458 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1052585003459 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1052585003460 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1052585003461 dinuclear metal binding motif [ion binding]; other site 1052585003462 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1052585003463 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1052585003464 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1052585003465 Part of AAA domain; Region: AAA_19; pfam13245 1052585003466 Family description; Region: UvrD_C_2; pfam13538 1052585003467 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1052585003468 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1052585003469 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1052585003470 active site 1052585003471 metal binding site [ion binding]; metal-binding site 1052585003472 DNA binding site [nucleotide binding] 1052585003473 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1052585003474 exonuclease SbcC; Region: sbcc; TIGR00618 1052585003475 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1052585003476 Walker A/P-loop; other site 1052585003477 ATP binding site [chemical binding]; other site 1052585003478 Q-loop/lid; other site 1052585003479 ABC transporter signature motif; other site 1052585003480 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1052585003481 ABC transporter signature motif; other site 1052585003482 Walker B; other site 1052585003483 D-loop; other site 1052585003484 H-loop/switch region; other site 1052585003485 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1052585003486 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052585003487 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1052585003488 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1052585003489 Spore germination protein GerPC; Region: GerPC; pfam10737 1052585003490 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1052585003491 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052585003492 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052585003493 CotH protein; Region: CotH; pfam08757 1052585003494 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1052585003495 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1052585003496 hypothetical protein; Provisional; Region: PRK13673 1052585003497 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1052585003498 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1052585003499 active site 1052585003500 catalytic triad [active] 1052585003501 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1052585003502 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1052585003503 active site 1052585003504 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1052585003505 dimer interface [polypeptide binding]; other site 1052585003506 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1052585003507 Ligand Binding Site [chemical binding]; other site 1052585003508 Molecular Tunnel; other site 1052585003509 DinB family; Region: DinB; cl17821 1052585003510 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1052585003511 substrate binding pocket [chemical binding]; other site 1052585003512 substrate-Mg2+ binding site; other site 1052585003513 aspartate-rich region 1; other site 1052585003514 aspartate-rich region 2; other site 1052585003515 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052585003516 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1052585003517 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052585003518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585003519 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585003520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585003521 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585003522 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585003523 DNA binding site [nucleotide binding] 1052585003524 domain linker motif; other site 1052585003525 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052585003526 dimerization interface [polypeptide binding]; other site 1052585003527 ligand binding site [chemical binding]; other site 1052585003528 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585003529 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052585003530 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052585003531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1052585003532 Lysine efflux permease [General function prediction only]; Region: COG1279 1052585003533 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585003534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585003535 DNA-binding site [nucleotide binding]; DNA binding site 1052585003536 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585003537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003538 homodimer interface [polypeptide binding]; other site 1052585003539 catalytic residue [active] 1052585003540 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1052585003541 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052585003542 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052585003543 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052585003544 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052585003545 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1052585003546 ligand-binding site [chemical binding]; other site 1052585003547 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1052585003548 ATP-sulfurylase; Region: ATPS; cd00517 1052585003549 active site 1052585003550 HXXH motif; other site 1052585003551 flexible loop; other site 1052585003552 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1052585003553 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1052585003554 Active Sites [active] 1052585003555 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1052585003556 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 1052585003557 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 1052585003558 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585003559 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585003560 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1052585003561 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1052585003562 active site pocket [active] 1052585003563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585003564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585003565 putative substrate translocation pore; other site 1052585003566 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052585003567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1052585003568 Coenzyme A binding pocket [chemical binding]; other site 1052585003569 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1052585003570 Coenzyme A binding pocket [chemical binding]; other site 1052585003571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1052585003572 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1052585003573 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1052585003574 S1 domain; Region: S1_2; pfam13509 1052585003575 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1052585003576 RNA binding site [nucleotide binding]; other site 1052585003577 EDD domain protein, DegV family; Region: DegV; TIGR00762 1052585003578 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1052585003579 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052585003580 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1052585003581 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1052585003582 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052585003583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585003584 motif II; other site 1052585003585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585003586 esterase; Provisional; Region: PRK10566 1052585003587 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052585003588 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1052585003589 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1052585003590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585003591 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585003592 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1052585003593 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1052585003594 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1052585003595 heterotetramer interface [polypeptide binding]; other site 1052585003596 active site pocket [active] 1052585003597 cleavage site 1052585003598 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1052585003599 nucleotide binding site [chemical binding]; other site 1052585003600 N-acetyl-L-glutamate binding site [chemical binding]; other site 1052585003601 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1052585003602 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585003603 inhibitor-cofactor binding pocket; inhibition site 1052585003604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003605 catalytic residue [active] 1052585003606 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1052585003607 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1052585003608 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1052585003609 catalytic site [active] 1052585003610 subunit interface [polypeptide binding]; other site 1052585003611 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1052585003612 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585003613 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1052585003614 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1052585003615 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585003616 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1052585003617 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1052585003618 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1052585003619 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1052585003620 YjzC-like protein; Region: YjzC; pfam14168 1052585003621 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1052585003622 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1052585003623 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1052585003624 putative ligand binding site [chemical binding]; other site 1052585003625 ComZ; Region: ComZ; pfam10815 1052585003626 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1052585003627 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1052585003628 dimer interface [polypeptide binding]; other site 1052585003629 active site 1052585003630 CoA binding pocket [chemical binding]; other site 1052585003631 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1052585003632 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1052585003633 dimer interface [polypeptide binding]; other site 1052585003634 active site 1052585003635 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1052585003636 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052585003637 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052585003638 Walker A/P-loop; other site 1052585003639 ATP binding site [chemical binding]; other site 1052585003640 Q-loop/lid; other site 1052585003641 ABC transporter signature motif; other site 1052585003642 Walker B; other site 1052585003643 D-loop; other site 1052585003644 H-loop/switch region; other site 1052585003645 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1052585003646 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1052585003647 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052585003648 Walker A/P-loop; other site 1052585003649 ATP binding site [chemical binding]; other site 1052585003650 Q-loop/lid; other site 1052585003651 ABC transporter signature motif; other site 1052585003652 Walker B; other site 1052585003653 D-loop; other site 1052585003654 H-loop/switch region; other site 1052585003655 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1052585003656 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1052585003657 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1052585003658 peptide binding site [polypeptide binding]; other site 1052585003659 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052585003660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585003661 dimer interface [polypeptide binding]; other site 1052585003662 conserved gate region; other site 1052585003663 putative PBP binding loops; other site 1052585003664 ABC-ATPase subunit interface; other site 1052585003665 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052585003666 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052585003667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585003668 dimer interface [polypeptide binding]; other site 1052585003669 conserved gate region; other site 1052585003670 putative PBP binding loops; other site 1052585003671 ABC-ATPase subunit interface; other site 1052585003672 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1052585003673 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1052585003674 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1052585003675 active site 1052585003676 HIGH motif; other site 1052585003677 dimer interface [polypeptide binding]; other site 1052585003678 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052585003679 KMSKS motif; other site 1052585003680 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1052585003681 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1052585003682 peptide binding site [polypeptide binding]; other site 1052585003683 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1052585003684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585003685 dimer interface [polypeptide binding]; other site 1052585003686 conserved gate region; other site 1052585003687 putative PBP binding loops; other site 1052585003688 ABC-ATPase subunit interface; other site 1052585003689 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052585003690 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052585003691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585003692 dimer interface [polypeptide binding]; other site 1052585003693 conserved gate region; other site 1052585003694 putative PBP binding loops; other site 1052585003695 ABC-ATPase subunit interface; other site 1052585003696 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052585003697 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052585003698 Walker A/P-loop; other site 1052585003699 ATP binding site [chemical binding]; other site 1052585003700 Q-loop/lid; other site 1052585003701 ABC transporter signature motif; other site 1052585003702 Walker B; other site 1052585003703 D-loop; other site 1052585003704 H-loop/switch region; other site 1052585003705 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052585003706 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1052585003707 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052585003708 Walker A/P-loop; other site 1052585003709 ATP binding site [chemical binding]; other site 1052585003710 Q-loop/lid; other site 1052585003711 ABC transporter signature motif; other site 1052585003712 Walker B; other site 1052585003713 D-loop; other site 1052585003714 H-loop/switch region; other site 1052585003715 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1052585003716 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052585003717 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1052585003718 ArsC family; Region: ArsC; pfam03960 1052585003719 putative catalytic residues [active] 1052585003720 thiol/disulfide switch; other site 1052585003721 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1052585003722 adaptor protein; Provisional; Region: PRK02315 1052585003723 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 1052585003724 oligoendopeptidase F; Region: pepF; TIGR00181 1052585003725 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1052585003726 active site 1052585003727 Zn binding site [ion binding]; other site 1052585003728 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1052585003729 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1052585003730 catalytic residues [active] 1052585003731 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1052585003732 apolar tunnel; other site 1052585003733 heme binding site [chemical binding]; other site 1052585003734 dimerization interface [polypeptide binding]; other site 1052585003735 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1052585003736 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1052585003737 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052585003738 catalytic residue [active] 1052585003739 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1052585003740 putative active site [active] 1052585003741 putative metal binding residues [ion binding]; other site 1052585003742 signature motif; other site 1052585003743 putative triphosphate binding site [ion binding]; other site 1052585003744 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1052585003745 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052585003746 synthetase active site [active] 1052585003747 NTP binding site [chemical binding]; other site 1052585003748 metal binding site [ion binding]; metal-binding site 1052585003749 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1052585003750 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1052585003751 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1052585003752 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052585003753 active site 1052585003754 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1052585003755 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1052585003756 active site 1052585003757 metal binding site [ion binding]; metal-binding site 1052585003758 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1052585003759 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1052585003760 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052585003761 TrkA-N domain; Region: TrkA_N; pfam02254 1052585003762 TrkA-C domain; Region: TrkA_C; pfam02080 1052585003763 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1052585003764 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1052585003765 thiamine phosphate binding site [chemical binding]; other site 1052585003766 active site 1052585003767 pyrophosphate binding site [ion binding]; other site 1052585003768 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1052585003769 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1052585003770 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1052585003771 thiS-thiF/thiG interaction site; other site 1052585003772 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1052585003773 ThiS interaction site; other site 1052585003774 putative active site [active] 1052585003775 tetramer interface [polypeptide binding]; other site 1052585003776 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1052585003777 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1052585003778 ATP binding site [chemical binding]; other site 1052585003779 substrate interface [chemical binding]; other site 1052585003780 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1052585003781 dimer interface [polypeptide binding]; other site 1052585003782 substrate binding site [chemical binding]; other site 1052585003783 ATP binding site [chemical binding]; other site 1052585003784 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1052585003785 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1052585003786 NAD binding site [chemical binding]; other site 1052585003787 homotetramer interface [polypeptide binding]; other site 1052585003788 homodimer interface [polypeptide binding]; other site 1052585003789 substrate binding site [chemical binding]; other site 1052585003790 active site 1052585003791 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1052585003792 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1052585003793 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1052585003794 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1052585003795 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1052585003796 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1052585003797 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1052585003798 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1052585003799 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1052585003800 Part of AAA domain; Region: AAA_19; pfam13245 1052585003801 AAA domain; Region: AAA_14; pfam13173 1052585003802 Family description; Region: UvrD_C_2; pfam13538 1052585003803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585003804 Coenzyme A binding pocket [chemical binding]; other site 1052585003805 hypothetical protein; Provisional; Region: PRK13679 1052585003806 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052585003807 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1052585003808 Putative esterase; Region: Esterase; pfam00756 1052585003809 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1052585003810 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052585003811 homodimer interface [polypeptide binding]; other site 1052585003812 substrate-cofactor binding pocket; other site 1052585003813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003814 catalytic residue [active] 1052585003815 cystathionine beta-lyase; Provisional; Region: PRK08064 1052585003816 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052585003817 homodimer interface [polypeptide binding]; other site 1052585003818 substrate-cofactor binding pocket; other site 1052585003819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003820 catalytic residue [active] 1052585003821 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052585003822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052585003823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585003824 TPR motif; other site 1052585003825 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585003826 binding surface 1052585003827 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1052585003828 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052585003829 HTH domain; Region: HTH_11; pfam08279 1052585003830 PRD domain; Region: PRD; pfam00874 1052585003831 PRD domain; Region: PRD; pfam00874 1052585003832 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052585003833 active site 1052585003834 P-loop; other site 1052585003835 phosphorylation site [posttranslational modification] 1052585003836 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052585003837 active site 1052585003838 phosphorylation site [posttranslational modification] 1052585003839 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1052585003840 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1052585003841 active site 1052585003842 P-loop; other site 1052585003843 phosphorylation site [posttranslational modification] 1052585003844 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1052585003845 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052585003846 active site 1052585003847 phosphorylation site [posttranslational modification] 1052585003848 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1052585003849 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1052585003850 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052585003851 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052585003852 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1052585003853 putative deacylase active site [active] 1052585003854 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1052585003855 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 1052585003856 UbiA prenyltransferase family; Region: UbiA; pfam01040 1052585003857 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052585003858 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1052585003859 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052585003860 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 1052585003861 NodB motif; other site 1052585003862 active site 1052585003863 catalytic site [active] 1052585003864 Zn binding site [ion binding]; other site 1052585003865 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1052585003866 Putative motility protein; Region: YjfB_motility; pfam14070 1052585003867 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1052585003868 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1052585003869 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1052585003870 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1052585003871 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1052585003872 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1052585003873 4Fe-4S binding domain; Region: Fer4; pfam00037 1052585003874 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1052585003875 [4Fe-4S] binding site [ion binding]; other site 1052585003876 molybdopterin cofactor binding site; other site 1052585003877 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1052585003878 molybdopterin cofactor binding site; other site 1052585003879 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1052585003880 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052585003881 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1052585003882 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1052585003883 nudix motif; other site 1052585003884 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052585003885 Cytochrome P450; Region: p450; cl12078 1052585003886 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052585003887 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1052585003888 active site 1052585003889 TDP-binding site; other site 1052585003890 acceptor substrate-binding pocket; other site 1052585003891 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1052585003892 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052585003893 active site 1052585003894 TIGR00245 family protein; Region: TIGR00245 1052585003895 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1052585003896 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1052585003897 Walker A/P-loop; other site 1052585003898 ATP binding site [chemical binding]; other site 1052585003899 Q-loop/lid; other site 1052585003900 ABC transporter signature motif; other site 1052585003901 Walker B; other site 1052585003902 D-loop; other site 1052585003903 H-loop/switch region; other site 1052585003904 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1052585003905 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1052585003906 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1052585003907 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052585003908 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585003909 Glucuronate isomerase; Region: UxaC; pfam02614 1052585003910 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1052585003911 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1052585003912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585003913 putative substrate translocation pore; other site 1052585003914 Malate/L-lactate dehydrogenase; Region: Ldh_2; pfam02615 1052585003915 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052585003916 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1052585003917 putative NAD(P) binding site [chemical binding]; other site 1052585003918 catalytic Zn binding site [ion binding]; other site 1052585003919 structural Zn binding site [ion binding]; other site 1052585003920 mannonate dehydratase; Provisional; Region: PRK03906 1052585003921 mannonate dehydratase; Region: uxuA; TIGR00695 1052585003922 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1052585003923 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1052585003924 putative NAD(P) binding site [chemical binding]; other site 1052585003925 active site 1052585003926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585003927 D-galactonate transporter; Region: 2A0114; TIGR00893 1052585003928 putative substrate translocation pore; other site 1052585003929 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585003930 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585003931 DNA binding site [nucleotide binding] 1052585003932 domain linker motif; other site 1052585003933 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052585003934 dimerization interface [polypeptide binding]; other site 1052585003935 ligand binding site [chemical binding]; other site 1052585003936 altronate oxidoreductase; Provisional; Region: PRK03643 1052585003937 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1052585003938 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1052585003939 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1052585003940 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1052585003941 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1052585003942 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1052585003943 DinB family; Region: DinB; pfam05163 1052585003944 DinB superfamily; Region: DinB_2; pfam12867 1052585003945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585003946 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052585003947 Walker A motif; other site 1052585003948 ATP binding site [chemical binding]; other site 1052585003949 Walker B motif; other site 1052585003950 arginine finger; other site 1052585003951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585003952 binding surface 1052585003953 TPR motif; other site 1052585003954 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585003955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585003956 binding surface 1052585003957 TPR motif; other site 1052585003958 YCII-related domain; Region: YCII; cl00999 1052585003959 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1052585003960 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052585003961 amidase catalytic site [active] 1052585003962 Zn binding residues [ion binding]; other site 1052585003963 substrate binding site [chemical binding]; other site 1052585003964 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585003965 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052585003966 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052585003967 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1052585003968 pentamer interface [polypeptide binding]; other site 1052585003969 dodecaamer interface [polypeptide binding]; other site 1052585003970 Phage-related replication protein [General function prediction only]; Region: COG4195 1052585003971 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052585003972 dimanganese center [ion binding]; other site 1052585003973 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1052585003974 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052585003975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585003976 non-specific DNA binding site [nucleotide binding]; other site 1052585003977 salt bridge; other site 1052585003978 sequence-specific DNA binding site [nucleotide binding]; other site 1052585003979 hypothetical protein; Provisional; Region: PRK06921 1052585003980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585003981 Walker A motif; other site 1052585003982 ATP binding site [chemical binding]; other site 1052585003983 Walker B motif; other site 1052585003984 positive control sigma-like factor; Validated; Region: PRK06930 1052585003985 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585003986 DNA binding residues [nucleotide binding] 1052585003987 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1052585003988 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1052585003989 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1052585003990 Terminase-like family; Region: Terminase_6; pfam03237 1052585003991 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1052585003992 Phage capsid family; Region: Phage_capsid; pfam05065 1052585003993 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 1052585003994 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1052585003995 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1052585003996 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1052585003997 Phage XkdN-like protein; Region: XkdN; pfam08890 1052585003998 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1052585003999 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1052585004000 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1052585004001 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052585004002 catalytic residue [active] 1052585004003 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1052585004004 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585004005 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 1052585004006 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1052585004007 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1052585004008 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1052585004009 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1052585004010 XkdW protein; Region: XkdW; pfam09636 1052585004011 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1052585004012 Haemolysin XhlA; Region: XhlA; pfam10779 1052585004013 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1052585004014 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052585004015 amidase catalytic site [active] 1052585004016 Zn binding residues [ion binding]; other site 1052585004017 substrate binding site [chemical binding]; other site 1052585004018 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585004019 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1052585004020 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052585004021 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052585004022 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1052585004023 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1052585004024 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1052585004025 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1052585004026 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1052585004027 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052585004028 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585004029 Zn binding site [ion binding]; other site 1052585004030 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052585004031 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585004032 Zn binding site [ion binding]; other site 1052585004033 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1052585004034 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1052585004035 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1052585004036 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1052585004037 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052585004038 Ligand binding site; other site 1052585004039 Putative Catalytic site; other site 1052585004040 DXD motif; other site 1052585004041 Trypsin; Region: Trypsin; pfam00089 1052585004042 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052585004043 protein binding site [polypeptide binding]; other site 1052585004044 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 1052585004045 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1052585004046 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1052585004047 SxDxEG motif; other site 1052585004048 active site 1052585004049 metal binding site [ion binding]; metal-binding site 1052585004050 homopentamer interface [polypeptide binding]; other site 1052585004051 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052585004052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585004053 dimer interface [polypeptide binding]; other site 1052585004054 conserved gate region; other site 1052585004055 putative PBP binding loops; other site 1052585004056 ABC-ATPase subunit interface; other site 1052585004057 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052585004058 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052585004059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585004060 putative PBP binding loops; other site 1052585004061 dimer interface [polypeptide binding]; other site 1052585004062 ABC-ATPase subunit interface; other site 1052585004063 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052585004064 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052585004065 Walker A/P-loop; other site 1052585004066 ATP binding site [chemical binding]; other site 1052585004067 Q-loop/lid; other site 1052585004068 ABC transporter signature motif; other site 1052585004069 Walker B; other site 1052585004070 D-loop; other site 1052585004071 H-loop/switch region; other site 1052585004072 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052585004073 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1052585004074 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1052585004075 peptide binding site [polypeptide binding]; other site 1052585004076 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1052585004077 dimer interface [polypeptide binding]; other site 1052585004078 catalytic triad [active] 1052585004079 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1052585004080 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1052585004081 active site 1052585004082 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052585004083 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052585004084 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1052585004085 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052585004086 Walker A/P-loop; other site 1052585004087 ATP binding site [chemical binding]; other site 1052585004088 Q-loop/lid; other site 1052585004089 ABC transporter signature motif; other site 1052585004090 Walker B; other site 1052585004091 D-loop; other site 1052585004092 H-loop/switch region; other site 1052585004093 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1052585004094 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1052585004095 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1052585004096 Amidinotransferase; Region: Amidinotransf; pfam02274 1052585004097 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1052585004098 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1052585004099 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1052585004100 heme-binding site [chemical binding]; other site 1052585004101 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1052585004102 FAD binding pocket [chemical binding]; other site 1052585004103 FAD binding motif [chemical binding]; other site 1052585004104 phosphate binding motif [ion binding]; other site 1052585004105 beta-alpha-beta structure motif; other site 1052585004106 NAD binding pocket [chemical binding]; other site 1052585004107 Heme binding pocket [chemical binding]; other site 1052585004108 Predicted membrane protein [Function unknown]; Region: COG2323 1052585004109 DinB superfamily; Region: DinB_2; pfam12867 1052585004110 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052585004111 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052585004112 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1052585004113 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052585004114 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1052585004115 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1052585004116 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1052585004117 putative active site [active] 1052585004118 putative substrate binding site [chemical binding]; other site 1052585004119 putative cosubstrate binding site; other site 1052585004120 catalytic site [active] 1052585004121 glutamate 5-kinase; Region: proB; TIGR01027 1052585004122 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1052585004123 nucleotide binding site [chemical binding]; other site 1052585004124 homotetrameric interface [polypeptide binding]; other site 1052585004125 putative phosphate binding site [ion binding]; other site 1052585004126 putative allosteric binding site; other site 1052585004127 PUA domain; Region: PUA; pfam01472 1052585004128 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1052585004129 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1052585004130 putative catalytic cysteine [active] 1052585004131 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1052585004132 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585004133 MarR family; Region: MarR; pfam01047 1052585004134 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1052585004135 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052585004136 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1052585004137 putative metal binding site; other site 1052585004138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585004139 binding surface 1052585004140 TPR motif; other site 1052585004141 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1052585004142 nucleoside/Zn binding site; other site 1052585004143 dimer interface [polypeptide binding]; other site 1052585004144 catalytic motif [active] 1052585004145 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052585004146 catalytic core [active] 1052585004147 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1052585004148 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1052585004149 THF binding site; other site 1052585004150 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052585004151 substrate binding site [chemical binding]; other site 1052585004152 THF binding site; other site 1052585004153 zinc-binding site [ion binding]; other site 1052585004154 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052585004155 active site 1052585004156 catalytic residues [active] 1052585004157 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585004158 Cobalt transport protein; Region: CbiQ; pfam02361 1052585004159 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1052585004160 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052585004161 Walker A/P-loop; other site 1052585004162 ATP binding site [chemical binding]; other site 1052585004163 Q-loop/lid; other site 1052585004164 ABC transporter signature motif; other site 1052585004165 Walker B; other site 1052585004166 D-loop; other site 1052585004167 H-loop/switch region; other site 1052585004168 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1052585004169 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052585004170 Walker A/P-loop; other site 1052585004171 ATP binding site [chemical binding]; other site 1052585004172 Q-loop/lid; other site 1052585004173 ABC transporter signature motif; other site 1052585004174 Walker B; other site 1052585004175 D-loop; other site 1052585004176 H-loop/switch region; other site 1052585004177 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1052585004178 YKOF-related Family; Region: Ykof; pfam07615 1052585004179 YKOF-related Family; Region: Ykof; pfam07615 1052585004180 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585004181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585004182 active site 1052585004183 phosphorylation site [posttranslational modification] 1052585004184 intermolecular recognition site; other site 1052585004185 dimerization interface [polypeptide binding]; other site 1052585004186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585004187 DNA binding site [nucleotide binding] 1052585004188 Predicted membrane protein [Function unknown]; Region: COG3212 1052585004189 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052585004190 Predicted membrane protein [Function unknown]; Region: COG3212 1052585004191 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052585004192 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052585004193 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1052585004194 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1052585004195 MgtE intracellular N domain; Region: MgtE_N; smart00924 1052585004196 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1052585004197 Divalent cation transporter; Region: MgtE; pfam01769 1052585004198 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1052585004199 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052585004200 DNA binding residues [nucleotide binding] 1052585004201 putative dimer interface [polypeptide binding]; other site 1052585004202 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585004203 MarR family; Region: MarR; pfam01047 1052585004204 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 1052585004205 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1052585004206 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1052585004207 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052585004208 putative active site [active] 1052585004209 putative metal binding site [ion binding]; other site 1052585004210 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1052585004211 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052585004212 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052585004213 Ligand binding site; other site 1052585004214 Putative Catalytic site; other site 1052585004215 DXD motif; other site 1052585004216 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1052585004217 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1052585004218 active site 1052585004219 DNA binding site [nucleotide binding] 1052585004220 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1052585004221 nucleotide binding site [chemical binding]; other site 1052585004222 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 1052585004223 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1052585004224 putative DNA binding site [nucleotide binding]; other site 1052585004225 putative homodimer interface [polypeptide binding]; other site 1052585004226 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1052585004227 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1052585004228 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1052585004229 PAS domain; Region: PAS_9; pfam13426 1052585004230 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052585004231 metal binding site [ion binding]; metal-binding site 1052585004232 active site 1052585004233 I-site; other site 1052585004234 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1052585004235 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1052585004236 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052585004237 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1052585004238 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1052585004239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585004240 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1052585004241 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052585004242 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1052585004243 heat shock protein HtpX; Provisional; Region: PRK05457 1052585004244 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1052585004245 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1052585004246 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1052585004247 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052585004248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585004249 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1052585004250 putative active site [active] 1052585004251 heme pocket [chemical binding]; other site 1052585004252 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585004253 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1052585004254 putative active site [active] 1052585004255 heme pocket [chemical binding]; other site 1052585004256 PAS domain; Region: PAS; smart00091 1052585004257 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052585004258 PAS domain; Region: PAS; smart00091 1052585004259 putative active site [active] 1052585004260 heme pocket [chemical binding]; other site 1052585004261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585004262 dimer interface [polypeptide binding]; other site 1052585004263 phosphorylation site [posttranslational modification] 1052585004264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585004265 ATP binding site [chemical binding]; other site 1052585004266 Mg2+ binding site [ion binding]; other site 1052585004267 G-X-G motif; other site 1052585004268 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1052585004269 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1052585004270 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1052585004271 DNA binding site [nucleotide binding] 1052585004272 active site 1052585004273 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1052585004274 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1052585004275 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1052585004276 Phosphotransferase enzyme family; Region: APH; pfam01636 1052585004277 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1052585004278 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1052585004279 putative active site [active] 1052585004280 catalytic triad [active] 1052585004281 putative dimer interface [polypeptide binding]; other site 1052585004282 transaminase; Reviewed; Region: PRK08068 1052585004283 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585004284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585004285 homodimer interface [polypeptide binding]; other site 1052585004286 catalytic residue [active] 1052585004287 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 1052585004288 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1052585004289 dimer interface [polypeptide binding]; other site 1052585004290 active site 1052585004291 catalytic residue [active] 1052585004292 metal binding site [ion binding]; metal-binding site 1052585004293 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1052585004294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585004295 motif II; other site 1052585004296 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1052585004297 intersubunit interface [polypeptide binding]; other site 1052585004298 active site 1052585004299 Zn2+ binding site [ion binding]; other site 1052585004300 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1052585004301 Cupin domain; Region: Cupin_2; pfam07883 1052585004302 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1052585004303 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052585004304 Cache domain; Region: Cache_1; pfam02743 1052585004305 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1052585004306 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585004307 dimer interface [polypeptide binding]; other site 1052585004308 phosphorylation site [posttranslational modification] 1052585004309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585004310 ATP binding site [chemical binding]; other site 1052585004311 Mg2+ binding site [ion binding]; other site 1052585004312 G-X-G motif; other site 1052585004313 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585004314 MarR family; Region: MarR; pfam01047 1052585004315 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1052585004316 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1052585004317 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1052585004318 ligand binding site [chemical binding]; other site 1052585004319 flagellar motor protein MotA; Validated; Region: PRK08124 1052585004320 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1052585004321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585004322 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052585004323 Walker A motif; other site 1052585004324 ATP binding site [chemical binding]; other site 1052585004325 Walker B motif; other site 1052585004326 arginine finger; other site 1052585004327 UvrB/uvrC motif; Region: UVR; pfam02151 1052585004328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585004329 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052585004330 Walker A motif; other site 1052585004331 ATP binding site [chemical binding]; other site 1052585004332 Walker B motif; other site 1052585004333 arginine finger; other site 1052585004334 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1052585004335 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1052585004336 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1052585004337 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1052585004338 Ligand Binding Site [chemical binding]; other site 1052585004339 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1052585004340 active site 1052585004341 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1052585004342 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1052585004343 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1052585004344 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1052585004345 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585004346 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1052585004347 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1052585004348 active site 1052585004349 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1052585004350 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1052585004351 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1052585004352 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052585004353 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1052585004354 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052585004355 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052585004356 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585004357 motif II; other site 1052585004358 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1052585004359 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1052585004360 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1052585004361 active site 1052585004362 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585004363 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585004364 DNA binding site [nucleotide binding] 1052585004365 domain linker motif; other site 1052585004366 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1052585004367 putative dimerization interface [polypeptide binding]; other site 1052585004368 putative ligand binding site [chemical binding]; other site 1052585004369 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052585004370 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1052585004371 PRD domain; Region: PRD; pfam00874 1052585004372 PRD domain; Region: PRD; pfam00874 1052585004373 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052585004374 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1052585004375 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585004376 active site turn [active] 1052585004377 phosphorylation site [posttranslational modification] 1052585004378 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1052585004379 HPr interaction site; other site 1052585004380 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585004381 active site 1052585004382 phosphorylation site [posttranslational modification] 1052585004383 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052585004384 dimerization domain swap beta strand [polypeptide binding]; other site 1052585004385 regulatory protein interface [polypeptide binding]; other site 1052585004386 active site 1052585004387 regulatory phosphorylation site [posttranslational modification]; other site 1052585004388 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1052585004389 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1052585004390 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1052585004391 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1052585004392 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1052585004393 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1052585004394 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585004395 FeS/SAM binding site; other site 1052585004396 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052585004397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585004398 Coenzyme A binding pocket [chemical binding]; other site 1052585004399 Cache domain; Region: Cache_1; pfam02743 1052585004400 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585004401 dimerization interface [polypeptide binding]; other site 1052585004402 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585004403 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585004404 dimer interface [polypeptide binding]; other site 1052585004405 putative CheW interface [polypeptide binding]; other site 1052585004406 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1052585004407 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1052585004408 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1052585004409 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1052585004410 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585004411 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585004412 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052585004413 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052585004414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585004415 putative active site [active] 1052585004416 heme pocket [chemical binding]; other site 1052585004417 PAS fold; Region: PAS; pfam00989 1052585004418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585004419 putative active site [active] 1052585004420 heme pocket [chemical binding]; other site 1052585004421 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052585004422 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585004423 putative active site [active] 1052585004424 heme pocket [chemical binding]; other site 1052585004425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585004426 dimer interface [polypeptide binding]; other site 1052585004427 phosphorylation site [posttranslational modification] 1052585004428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585004429 ATP binding site [chemical binding]; other site 1052585004430 Mg2+ binding site [ion binding]; other site 1052585004431 G-X-G motif; other site 1052585004432 aminotransferase A; Validated; Region: PRK07683 1052585004433 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585004434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585004435 homodimer interface [polypeptide binding]; other site 1052585004436 catalytic residue [active] 1052585004437 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1052585004438 putative CheA interaction surface; other site 1052585004439 Response regulator receiver domain; Region: Response_reg; pfam00072 1052585004440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585004441 active site 1052585004442 phosphorylation site [posttranslational modification] 1052585004443 intermolecular recognition site; other site 1052585004444 dimerization interface [polypeptide binding]; other site 1052585004445 YkyB-like protein; Region: YkyB; pfam14177 1052585004446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585004447 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052585004448 putative substrate translocation pore; other site 1052585004449 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585004450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1052585004451 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1052585004452 phosphodiesterase YaeI; Provisional; Region: PRK11340 1052585004453 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1052585004454 putative active site [active] 1052585004455 putative metal binding site [ion binding]; other site 1052585004456 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1052585004457 short chain dehydrogenase; Provisional; Region: PRK07677 1052585004458 NAD(P) binding site [chemical binding]; other site 1052585004459 substrate binding site [chemical binding]; other site 1052585004460 homotetramer interface [polypeptide binding]; other site 1052585004461 active site 1052585004462 homodimer interface [polypeptide binding]; other site 1052585004463 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1052585004464 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1052585004465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 1052585004466 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1052585004467 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1052585004468 FOG: CBS domain [General function prediction only]; Region: COG0517 1052585004469 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1052585004470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585004471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585004472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585004473 dimerization interface [polypeptide binding]; other site 1052585004474 flavodoxin; Provisional; Region: PRK06703 1052585004475 BNR repeat-like domain; Region: BNR_2; pfam13088 1052585004476 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1052585004477 flavodoxin, short chain; Region: flav_short; TIGR01753 1052585004478 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1052585004479 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1052585004480 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1052585004481 active site 1052585004482 trimer interface [polypeptide binding]; other site 1052585004483 substrate binding site [chemical binding]; other site 1052585004484 CoA binding site [chemical binding]; other site 1052585004485 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052585004486 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1052585004487 metal binding site [ion binding]; metal-binding site 1052585004488 putative dimer interface [polypeptide binding]; other site 1052585004489 hypothetical protein; Provisional; Region: PRK03094 1052585004490 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1052585004491 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1052585004492 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1052585004493 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1052585004494 dimer interface [polypeptide binding]; other site 1052585004495 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1052585004496 catalytic triad [active] 1052585004497 peroxidatic and resolving cysteines [active] 1052585004498 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052585004499 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052585004500 catalytic residues [active] 1052585004501 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1052585004502 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1052585004503 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1052585004504 GTP binding site; other site 1052585004505 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1052585004506 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1052585004507 ATP binding site [chemical binding]; other site 1052585004508 substrate interface [chemical binding]; other site 1052585004509 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1052585004510 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1052585004511 dimer interface [polypeptide binding]; other site 1052585004512 putative functional site; other site 1052585004513 putative MPT binding site; other site 1052585004514 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1052585004515 Walker A motif; other site 1052585004516 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1052585004517 MoaE homodimer interface [polypeptide binding]; other site 1052585004518 MoaD interaction [polypeptide binding]; other site 1052585004519 active site residues [active] 1052585004520 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1052585004521 MoaE interaction surface [polypeptide binding]; other site 1052585004522 MoeB interaction surface [polypeptide binding]; other site 1052585004523 thiocarboxylated glycine; other site 1052585004524 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585004525 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052585004526 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1052585004527 Walker A/P-loop; other site 1052585004528 ATP binding site [chemical binding]; other site 1052585004529 Q-loop/lid; other site 1052585004530 ABC transporter signature motif; other site 1052585004531 Walker B; other site 1052585004532 D-loop; other site 1052585004533 H-loop/switch region; other site 1052585004534 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585004535 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052585004536 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1052585004537 Walker A/P-loop; other site 1052585004538 ATP binding site [chemical binding]; other site 1052585004539 Q-loop/lid; other site 1052585004540 ABC transporter signature motif; other site 1052585004541 Walker B; other site 1052585004542 D-loop; other site 1052585004543 H-loop/switch region; other site 1052585004544 Yip1 domain; Region: Yip1; pfam04893 1052585004545 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1052585004546 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1052585004547 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052585004548 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585004549 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052585004550 Walker A/P-loop; other site 1052585004551 ATP binding site [chemical binding]; other site 1052585004552 Q-loop/lid; other site 1052585004553 ABC transporter signature motif; other site 1052585004554 Walker B; other site 1052585004555 D-loop; other site 1052585004556 H-loop/switch region; other site 1052585004557 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052585004558 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052585004559 FtsX-like permease family; Region: FtsX; pfam02687 1052585004560 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052585004561 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1052585004562 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1052585004563 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1052585004564 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1052585004565 putative substrate binding site [chemical binding]; other site 1052585004566 putative ATP binding site [chemical binding]; other site 1052585004567 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1052585004568 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052585004569 active site 1052585004570 phosphorylation site [posttranslational modification] 1052585004571 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1052585004572 active site 1052585004573 P-loop; other site 1052585004574 phosphorylation site [posttranslational modification] 1052585004575 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1052585004576 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052585004577 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052585004578 Catalytic site [active] 1052585004579 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1052585004580 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052585004581 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052585004582 ABC transporter; Region: ABC_tran_2; pfam12848 1052585004583 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052585004584 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1052585004585 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1052585004586 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1052585004587 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1052585004588 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1052585004589 rod-share determining protein MreBH; Provisional; Region: PRK13929 1052585004590 MreB and similar proteins; Region: MreB_like; cd10225 1052585004591 nucleotide binding site [chemical binding]; other site 1052585004592 Mg binding site [ion binding]; other site 1052585004593 putative protofilament interaction site [polypeptide binding]; other site 1052585004594 RodZ interaction site [polypeptide binding]; other site 1052585004595 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1052585004596 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1052585004597 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1052585004598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585004599 putative active site [active] 1052585004600 heme pocket [chemical binding]; other site 1052585004601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585004602 dimer interface [polypeptide binding]; other site 1052585004603 phosphorylation site [posttranslational modification] 1052585004604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585004605 ATP binding site [chemical binding]; other site 1052585004606 Mg2+ binding site [ion binding]; other site 1052585004607 G-X-G motif; other site 1052585004608 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1052585004609 putative active site pocket [active] 1052585004610 dimerization interface [polypeptide binding]; other site 1052585004611 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1052585004612 putative active site pocket [active] 1052585004613 dimerization interface [polypeptide binding]; other site 1052585004614 putative catalytic residue [active] 1052585004615 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052585004616 TrkA-N domain; Region: TrkA_N; pfam02254 1052585004617 TrkA-C domain; Region: TrkA_C; pfam02080 1052585004618 adenine deaminase; Region: ade; TIGR01178 1052585004619 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052585004620 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1052585004621 active site 1052585004622 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1052585004623 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1052585004624 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1052585004625 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1052585004626 hypothetical protein; Provisional; Region: PRK13667 1052585004627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585004628 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052585004629 active site 1052585004630 motif I; other site 1052585004631 motif II; other site 1052585004632 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585004633 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1052585004634 active site 1052585004635 catalytic residues [active] 1052585004636 metal binding site [ion binding]; metal-binding site 1052585004637 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1052585004638 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1052585004639 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052585004640 TPP-binding site [chemical binding]; other site 1052585004641 tetramer interface [polypeptide binding]; other site 1052585004642 heterodimer interface [polypeptide binding]; other site 1052585004643 phosphorylation loop region [posttranslational modification] 1052585004644 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052585004645 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052585004646 alpha subunit interface [polypeptide binding]; other site 1052585004647 TPP binding site [chemical binding]; other site 1052585004648 heterodimer interface [polypeptide binding]; other site 1052585004649 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052585004650 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1052585004651 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052585004652 E3 interaction surface; other site 1052585004653 lipoyl attachment site [posttranslational modification]; other site 1052585004654 e3 binding domain; Region: E3_binding; pfam02817 1052585004655 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1052585004656 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1052585004657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1052585004658 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585004659 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052585004660 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1052585004661 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1052585004662 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1052585004663 homodimer interface [polypeptide binding]; other site 1052585004664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585004665 catalytic residue [active] 1052585004666 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1052585004667 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1052585004668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1052585004669 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1052585004670 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1052585004671 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1052585004672 active site 1052585004673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052585004674 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1052585004675 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1052585004676 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1052585004677 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1052585004678 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052585004679 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1052585004680 active site 1052585004681 Zn binding site [ion binding]; other site 1052585004682 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585004683 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1052585004684 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585004685 DNA binding residues [nucleotide binding] 1052585004686 Putative zinc-finger; Region: zf-HC2; pfam13490 1052585004687 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1052585004688 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1052585004689 G1 box; other site 1052585004690 putative GEF interaction site [polypeptide binding]; other site 1052585004691 GTP/Mg2+ binding site [chemical binding]; other site 1052585004692 Switch I region; other site 1052585004693 G2 box; other site 1052585004694 G3 box; other site 1052585004695 Switch II region; other site 1052585004696 G4 box; other site 1052585004697 G5 box; other site 1052585004698 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1052585004699 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1052585004700 YlaH-like protein; Region: YlaH; pfam14036 1052585004701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 1052585004702 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1052585004703 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052585004704 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1052585004705 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1052585004706 putative active site [active] 1052585004707 PhoH-like protein; Region: PhoH; pfam02562 1052585004708 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1052585004709 glutaminase A; Region: Gln_ase; TIGR03814 1052585004710 hypothetical protein; Provisional; Region: PRK13666 1052585004711 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1052585004712 pyruvate carboxylase; Reviewed; Region: PRK12999 1052585004713 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585004714 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1052585004715 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1052585004716 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1052585004717 active site 1052585004718 catalytic residues [active] 1052585004719 metal binding site [ion binding]; metal-binding site 1052585004720 homodimer binding site [polypeptide binding]; other site 1052585004721 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052585004722 carboxyltransferase (CT) interaction site; other site 1052585004723 biotinylation site [posttranslational modification]; other site 1052585004724 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1052585004725 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1052585004726 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1052585004727 UbiA prenyltransferase family; Region: UbiA; pfam01040 1052585004728 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1052585004729 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1052585004730 Cytochrome c; Region: Cytochrom_C; pfam00034 1052585004731 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1052585004732 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1052585004733 D-pathway; other site 1052585004734 Putative ubiquinol binding site [chemical binding]; other site 1052585004735 Low-spin heme (heme b) binding site [chemical binding]; other site 1052585004736 Putative water exit pathway; other site 1052585004737 Binuclear center (heme o3/CuB) [ion binding]; other site 1052585004738 K-pathway; other site 1052585004739 Putative proton exit pathway; other site 1052585004740 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1052585004741 Subunit I/III interface [polypeptide binding]; other site 1052585004742 Subunit III/IV interface [polypeptide binding]; other site 1052585004743 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1052585004744 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 1052585004745 YugN-like family; Region: YugN; pfam08868 1052585004746 FOG: CBS domain [General function prediction only]; Region: COG0517 1052585004747 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1052585004748 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1052585004749 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1052585004750 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1052585004751 Putative coat protein; Region: YlbD_coat; pfam14071 1052585004752 YlbE-like protein; Region: YlbE; pfam14003 1052585004753 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1052585004754 hypothetical protein; Provisional; Region: PRK02886 1052585004755 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1052585004756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585004757 S-adenosylmethionine binding site [chemical binding]; other site 1052585004758 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1052585004759 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1052585004760 active site 1052585004761 (T/H)XGH motif; other site 1052585004762 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1052585004763 Nucleoside recognition; Region: Gate; pfam07670 1052585004764 Nucleoside recognition; Region: Gate; pfam07670 1052585004765 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1052585004766 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1052585004767 nucleophile elbow; other site 1052585004768 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1052585004769 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1052585004770 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1052585004771 protein binding site [polypeptide binding]; other site 1052585004772 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1052585004773 hypothetical protein; Provisional; Region: PRK13670 1052585004774 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1052585004775 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1052585004776 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1052585004777 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1052585004778 hypothetical protein; Provisional; Region: PRK13688 1052585004779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585004780 Coenzyme A binding pocket [chemical binding]; other site 1052585004781 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 1052585004782 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1052585004783 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1052585004784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1052585004785 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1052585004786 mraZ protein; Region: TIGR00242 1052585004787 MraZ protein; Region: MraZ; pfam02381 1052585004788 MraZ protein; Region: MraZ; pfam02381 1052585004789 MraW methylase family; Region: Methyltransf_5; pfam01795 1052585004790 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1052585004791 Cell division protein FtsL; Region: FtsL; cl11433 1052585004792 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052585004793 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585004794 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052585004795 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1052585004796 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1052585004797 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1052585004798 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585004799 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052585004800 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1052585004801 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1052585004802 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1052585004803 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052585004804 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052585004805 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1052585004806 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1052585004807 Mg++ binding site [ion binding]; other site 1052585004808 putative catalytic motif [active] 1052585004809 putative substrate binding site [chemical binding]; other site 1052585004810 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1052585004811 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052585004812 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052585004813 stage V sporulation protein E; Region: spoVE; TIGR02615 1052585004814 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1052585004815 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1052585004816 active site 1052585004817 homodimer interface [polypeptide binding]; other site 1052585004818 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1052585004819 FAD binding domain; Region: FAD_binding_4; pfam01565 1052585004820 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1052585004821 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1052585004822 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1052585004823 Cell division protein FtsQ; Region: FtsQ; pfam03799 1052585004824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1052585004825 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1052585004826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1052585004827 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1052585004828 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 1052585004829 cell division protein FtsA; Region: ftsA; TIGR01174 1052585004830 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052585004831 nucleotide binding site [chemical binding]; other site 1052585004832 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1052585004833 Cell division protein FtsA; Region: FtsA; pfam14450 1052585004834 cell division protein FtsZ; Validated; Region: PRK09330 1052585004835 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1052585004836 nucleotide binding site [chemical binding]; other site 1052585004837 SulA interaction site; other site 1052585004838 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052585004839 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1052585004840 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1052585004841 active site 1052585004842 catalytic triad [active] 1052585004843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1052585004844 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1052585004845 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1052585004846 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1052585004847 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1052585004848 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1052585004849 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1052585004850 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1052585004851 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585004852 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585004853 DNA binding residues [nucleotide binding] 1052585004854 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1052585004855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585004856 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052585004857 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585004858 DNA binding residues [nucleotide binding] 1052585004859 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052585004860 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052585004861 Walker A/P-loop; other site 1052585004862 ATP binding site [chemical binding]; other site 1052585004863 Q-loop/lid; other site 1052585004864 ABC transporter signature motif; other site 1052585004865 Walker B; other site 1052585004866 D-loop; other site 1052585004867 H-loop/switch region; other site 1052585004868 acetylornithine deacetylase; Validated; Region: PRK08596 1052585004869 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1052585004870 metal binding site [ion binding]; metal-binding site 1052585004871 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1052585004872 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1052585004873 uncharacterized protein, YfiH family; Region: TIGR00726 1052585004874 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1052585004875 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052585004876 catalytic residue [active] 1052585004877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1052585004878 YGGT family; Region: YGGT; pfam02325 1052585004879 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1052585004880 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585004881 RNA binding surface [nucleotide binding]; other site 1052585004882 DivIVA protein; Region: DivIVA; pfam05103 1052585004883 DivIVA domain; Region: DivI1A_domain; TIGR03544 1052585004884 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1052585004885 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1052585004886 HIGH motif; other site 1052585004887 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1052585004888 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1052585004889 active site 1052585004890 KMSKS motif; other site 1052585004891 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1052585004892 tRNA binding surface [nucleotide binding]; other site 1052585004893 anticodon binding site; other site 1052585004894 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1052585004895 lipoprotein signal peptidase; Region: lspA; TIGR00077 1052585004896 lipoprotein signal peptidase; Provisional; Region: PRK14787 1052585004897 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1052585004898 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585004899 RNA binding surface [nucleotide binding]; other site 1052585004900 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052585004901 active site 1052585004902 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1052585004903 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585004904 active site 1052585004905 uracil-xanthine permease; Region: ncs2; TIGR00801 1052585004906 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1052585004907 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1052585004908 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1052585004909 dihydroorotase; Validated; Region: pyrC; PRK09357 1052585004910 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1052585004911 active site 1052585004912 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1052585004913 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1052585004914 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1052585004915 catalytic site [active] 1052585004916 subunit interface [polypeptide binding]; other site 1052585004917 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1052585004918 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585004919 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1052585004920 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1052585004921 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585004922 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1052585004923 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1052585004924 IMP binding site; other site 1052585004925 dimer interface [polypeptide binding]; other site 1052585004926 interdomain contacts; other site 1052585004927 partial ornithine binding site; other site 1052585004928 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1052585004929 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1052585004930 FAD binding pocket [chemical binding]; other site 1052585004931 FAD binding motif [chemical binding]; other site 1052585004932 phosphate binding motif [ion binding]; other site 1052585004933 beta-alpha-beta structure motif; other site 1052585004934 NAD binding pocket [chemical binding]; other site 1052585004935 Iron coordination center [ion binding]; other site 1052585004936 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1052585004937 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1052585004938 heterodimer interface [polypeptide binding]; other site 1052585004939 active site 1052585004940 FMN binding site [chemical binding]; other site 1052585004941 homodimer interface [polypeptide binding]; other site 1052585004942 substrate binding site [chemical binding]; other site 1052585004943 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1052585004944 active site 1052585004945 dimer interface [polypeptide binding]; other site 1052585004946 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585004947 active site 1052585004948 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1052585004949 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1052585004950 Active Sites [active] 1052585004951 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1052585004952 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1052585004953 ATP-sulfurylase; Region: ATPS; cd00517 1052585004954 active site 1052585004955 HXXH motif; other site 1052585004956 flexible loop; other site 1052585004957 AAA domain; Region: AAA_33; pfam13671 1052585004958 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1052585004959 ligand-binding site [chemical binding]; other site 1052585004960 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1052585004961 diphthine synthase; Region: dph5; TIGR00522 1052585004962 active site 1052585004963 SAM binding site [chemical binding]; other site 1052585004964 homodimer interface [polypeptide binding]; other site 1052585004965 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1052585004966 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1052585004967 putative active site [active] 1052585004968 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1052585004969 putative active site [active] 1052585004970 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1052585004971 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1052585004972 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1052585004973 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1052585004974 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1052585004975 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1052585004976 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052585004977 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1052585004978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585004979 motif II; other site 1052585004980 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1052585004981 TIGR00255 family protein; Region: TIGR00255 1052585004982 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1052585004983 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1052585004984 hypothetical protein; Provisional; Region: PRK04323 1052585004985 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1052585004986 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1052585004987 catalytic site [active] 1052585004988 G-X2-G-X-G-K; other site 1052585004989 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1052585004990 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1052585004991 Flavoprotein; Region: Flavoprotein; pfam02441 1052585004992 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1052585004993 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1052585004994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585004995 ATP binding site [chemical binding]; other site 1052585004996 putative Mg++ binding site [ion binding]; other site 1052585004997 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585004998 nucleotide binding region [chemical binding]; other site 1052585004999 ATP-binding site [chemical binding]; other site 1052585005000 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1052585005001 active site 1052585005002 catalytic residues [active] 1052585005003 metal binding site [ion binding]; metal-binding site 1052585005004 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1052585005005 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1052585005006 putative active site [active] 1052585005007 substrate binding site [chemical binding]; other site 1052585005008 putative cosubstrate binding site; other site 1052585005009 catalytic site [active] 1052585005010 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1052585005011 substrate binding site [chemical binding]; other site 1052585005012 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1052585005013 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1052585005014 putative RNA binding site [nucleotide binding]; other site 1052585005015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585005016 S-adenosylmethionine binding site [chemical binding]; other site 1052585005017 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1052585005018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585005019 FeS/SAM binding site; other site 1052585005020 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1052585005021 Protein phosphatase 2C; Region: PP2C; pfam00481 1052585005022 active site 1052585005023 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585005024 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1052585005025 active site 1052585005026 ATP binding site [chemical binding]; other site 1052585005027 substrate binding site [chemical binding]; other site 1052585005028 activation loop (A-loop); other site 1052585005029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1052585005030 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052585005031 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052585005032 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052585005033 GTPase RsgA; Reviewed; Region: PRK00098 1052585005034 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1052585005035 RNA binding site [nucleotide binding]; other site 1052585005036 homodimer interface [polypeptide binding]; other site 1052585005037 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1052585005038 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1052585005039 GTP/Mg2+ binding site [chemical binding]; other site 1052585005040 G4 box; other site 1052585005041 G5 box; other site 1052585005042 G1 box; other site 1052585005043 Switch I region; other site 1052585005044 G2 box; other site 1052585005045 G3 box; other site 1052585005046 Switch II region; other site 1052585005047 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1052585005048 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1052585005049 substrate binding site [chemical binding]; other site 1052585005050 hexamer interface [polypeptide binding]; other site 1052585005051 metal binding site [ion binding]; metal-binding site 1052585005052 Thiamine pyrophosphokinase; Region: TPK; cd07995 1052585005053 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1052585005054 active site 1052585005055 dimerization interface [polypeptide binding]; other site 1052585005056 thiamine binding site [chemical binding]; other site 1052585005057 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1052585005058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1052585005059 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1052585005060 DAK2 domain; Region: Dak2; pfam02734 1052585005061 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1052585005062 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1052585005063 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1052585005064 putative L-serine binding site [chemical binding]; other site 1052585005065 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Region: sda_alpha; TIGR00718 1052585005066 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1052585005067 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1052585005068 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1052585005069 generic binding surface II; other site 1052585005070 ssDNA binding site; other site 1052585005071 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585005072 ATP binding site [chemical binding]; other site 1052585005073 putative Mg++ binding site [ion binding]; other site 1052585005074 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585005075 nucleotide binding region [chemical binding]; other site 1052585005076 ATP-binding site [chemical binding]; other site 1052585005077 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1052585005078 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1052585005079 putative phosphate acyltransferase; Provisional; Region: PRK05331 1052585005080 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1052585005081 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052585005082 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1052585005083 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1052585005084 NAD(P) binding site [chemical binding]; other site 1052585005085 homotetramer interface [polypeptide binding]; other site 1052585005086 homodimer interface [polypeptide binding]; other site 1052585005087 active site 1052585005088 acyl carrier protein; Provisional; Region: acpP; PRK00982 1052585005089 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1052585005090 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1052585005091 dimerization interface [polypeptide binding]; other site 1052585005092 active site 1052585005093 metal binding site [ion binding]; metal-binding site 1052585005094 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1052585005095 dsRNA binding site [nucleotide binding]; other site 1052585005096 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1052585005097 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1052585005098 Walker A/P-loop; other site 1052585005099 ATP binding site [chemical binding]; other site 1052585005100 Q-loop/lid; other site 1052585005101 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1052585005102 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1052585005103 ABC transporter signature motif; other site 1052585005104 Walker B; other site 1052585005105 D-loop; other site 1052585005106 H-loop/switch region; other site 1052585005107 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1052585005108 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1052585005109 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1052585005110 GTP binding site [chemical binding]; other site 1052585005111 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1052585005112 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1052585005113 putative DNA-binding protein; Validated; Region: PRK00118 1052585005114 signal recognition particle protein; Provisional; Region: PRK10867 1052585005115 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1052585005116 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1052585005117 P loop; other site 1052585005118 GTP binding site [chemical binding]; other site 1052585005119 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1052585005120 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1052585005121 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1052585005122 KH domain; Region: KH_4; pfam13083 1052585005123 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1052585005124 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1052585005125 RimM N-terminal domain; Region: RimM; pfam01782 1052585005126 PRC-barrel domain; Region: PRC; pfam05239 1052585005127 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1052585005128 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1052585005129 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1052585005130 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1052585005131 GTP/Mg2+ binding site [chemical binding]; other site 1052585005132 G4 box; other site 1052585005133 G5 box; other site 1052585005134 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1052585005135 G1 box; other site 1052585005136 G1 box; other site 1052585005137 GTP/Mg2+ binding site [chemical binding]; other site 1052585005138 Switch I region; other site 1052585005139 G2 box; other site 1052585005140 G2 box; other site 1052585005141 G3 box; other site 1052585005142 G3 box; other site 1052585005143 Switch II region; other site 1052585005144 Switch II region; other site 1052585005145 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1052585005146 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1052585005147 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1052585005148 CoA-ligase; Region: Ligase_CoA; pfam00549 1052585005149 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1052585005150 CoA binding domain; Region: CoA_binding; smart00881 1052585005151 CoA-ligase; Region: Ligase_CoA; pfam00549 1052585005152 DNA protecting protein DprA; Region: dprA; TIGR00732 1052585005153 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1052585005154 DNA topoisomerase I; Validated; Region: PRK05582 1052585005155 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1052585005156 active site 1052585005157 interdomain interaction site; other site 1052585005158 putative metal-binding site [ion binding]; other site 1052585005159 nucleotide binding site [chemical binding]; other site 1052585005160 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1052585005161 domain I; other site 1052585005162 DNA binding groove [nucleotide binding] 1052585005163 phosphate binding site [ion binding]; other site 1052585005164 domain II; other site 1052585005165 domain III; other site 1052585005166 nucleotide binding site [chemical binding]; other site 1052585005167 catalytic site [active] 1052585005168 domain IV; other site 1052585005169 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1052585005170 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1052585005171 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1052585005172 Glucose inhibited division protein A; Region: GIDA; pfam01134 1052585005173 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1052585005174 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1052585005175 active site 1052585005176 Int/Topo IB signature motif; other site 1052585005177 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1052585005178 active site 1052585005179 HslU subunit interaction site [polypeptide binding]; other site 1052585005180 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1052585005181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585005182 Walker A motif; other site 1052585005183 ATP binding site [chemical binding]; other site 1052585005184 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1052585005185 Walker B motif; other site 1052585005186 arginine finger; other site 1052585005187 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1052585005188 transcriptional repressor CodY; Validated; Region: PRK04158 1052585005189 CodY GAF-like domain; Region: CodY; pfam06018 1052585005190 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1052585005191 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1052585005192 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1052585005193 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1052585005194 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1052585005195 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1052585005196 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1052585005197 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1052585005198 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1052585005199 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1052585005200 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1052585005201 MgtE intracellular N domain; Region: MgtE_N; smart00924 1052585005202 FliG C-terminal domain; Region: FliG_C; pfam01706 1052585005203 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 1052585005204 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1052585005205 Flagellar assembly protein FliH; Region: FliH; pfam02108 1052585005206 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1052585005207 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1052585005208 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1052585005209 Walker A motif/ATP binding site; other site 1052585005210 Walker B motif; other site 1052585005211 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1052585005212 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1052585005213 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1052585005214 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1052585005215 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1052585005216 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1052585005217 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1052585005218 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1052585005219 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1052585005220 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1052585005221 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 1052585005222 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 1052585005223 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1052585005224 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1052585005225 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1052585005226 flagellar motor switch protein; Validated; Region: PRK08119 1052585005227 CheC-like family; Region: CheC; pfam04509 1052585005228 CheC-like family; Region: CheC; pfam04509 1052585005229 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1052585005230 Response regulator receiver domain; Region: Response_reg; pfam00072 1052585005231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585005232 active site 1052585005233 phosphorylation site [posttranslational modification] 1052585005234 intermolecular recognition site; other site 1052585005235 dimerization interface [polypeptide binding]; other site 1052585005236 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 1052585005237 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1052585005238 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1052585005239 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1052585005240 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1052585005241 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1052585005242 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1052585005243 FHIPEP family; Region: FHIPEP; pfam00771 1052585005244 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1052585005245 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1052585005246 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1052585005247 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1052585005248 P-loop; other site 1052585005249 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1052585005250 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1052585005251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585005252 active site 1052585005253 phosphorylation site [posttranslational modification] 1052585005254 intermolecular recognition site; other site 1052585005255 dimerization interface [polypeptide binding]; other site 1052585005256 CheB methylesterase; Region: CheB_methylest; pfam01339 1052585005257 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1052585005258 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1052585005259 putative binding surface; other site 1052585005260 active site 1052585005261 P2 response regulator binding domain; Region: P2; pfam07194 1052585005262 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1052585005263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585005264 ATP binding site [chemical binding]; other site 1052585005265 Mg2+ binding site [ion binding]; other site 1052585005266 G-X-G motif; other site 1052585005267 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1052585005268 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1052585005269 putative CheA interaction surface; other site 1052585005270 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1052585005271 CheC-like family; Region: CheC; pfam04509 1052585005272 CheC-like family; Region: CheC; pfam04509 1052585005273 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1052585005274 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1052585005275 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585005276 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052585005277 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585005278 DNA binding residues [nucleotide binding] 1052585005279 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1052585005280 rRNA interaction site [nucleotide binding]; other site 1052585005281 S8 interaction site; other site 1052585005282 putative laminin-1 binding site; other site 1052585005283 elongation factor Ts; Provisional; Region: tsf; PRK09377 1052585005284 UBA/TS-N domain; Region: UBA; pfam00627 1052585005285 Elongation factor TS; Region: EF_TS; pfam00889 1052585005286 Elongation factor TS; Region: EF_TS; pfam00889 1052585005287 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1052585005288 putative nucleotide binding site [chemical binding]; other site 1052585005289 uridine monophosphate binding site [chemical binding]; other site 1052585005290 homohexameric interface [polypeptide binding]; other site 1052585005291 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1052585005292 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1052585005293 hinge region; other site 1052585005294 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1052585005295 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1052585005296 catalytic residue [active] 1052585005297 putative FPP diphosphate binding site; other site 1052585005298 putative FPP binding hydrophobic cleft; other site 1052585005299 dimer interface [polypeptide binding]; other site 1052585005300 putative IPP diphosphate binding site; other site 1052585005301 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1052585005302 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1052585005303 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1052585005304 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1052585005305 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1052585005306 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1052585005307 RIP metalloprotease RseP; Region: TIGR00054 1052585005308 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1052585005309 active site 1052585005310 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1052585005311 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1052585005312 protein binding site [polypeptide binding]; other site 1052585005313 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1052585005314 putative substrate binding region [chemical binding]; other site 1052585005315 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1052585005316 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1052585005317 dimer interface [polypeptide binding]; other site 1052585005318 motif 1; other site 1052585005319 active site 1052585005320 motif 2; other site 1052585005321 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1052585005322 putative deacylase active site [active] 1052585005323 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1052585005324 active site 1052585005325 motif 3; other site 1052585005326 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1052585005327 anticodon binding site; other site 1052585005328 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1052585005329 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1052585005330 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1052585005331 generic binding surface II; other site 1052585005332 generic binding surface I; other site 1052585005333 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1052585005334 active site 1052585005335 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1052585005336 active site 1052585005337 catalytic site [active] 1052585005338 substrate binding site [chemical binding]; other site 1052585005339 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1052585005340 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1052585005341 Sm and related proteins; Region: Sm_like; cl00259 1052585005342 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1052585005343 putative oligomer interface [polypeptide binding]; other site 1052585005344 putative RNA binding site [nucleotide binding]; other site 1052585005345 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1052585005346 NusA N-terminal domain; Region: NusA_N; pfam08529 1052585005347 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1052585005348 RNA binding site [nucleotide binding]; other site 1052585005349 homodimer interface [polypeptide binding]; other site 1052585005350 NusA-like KH domain; Region: KH_5; pfam13184 1052585005351 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1052585005352 G-X-X-G motif; other site 1052585005353 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1052585005354 putative RNA binding cleft [nucleotide binding]; other site 1052585005355 hypothetical protein; Provisional; Region: PRK07714 1052585005356 Translation-initiation factor 2; Region: IF-2; pfam11987 1052585005357 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1052585005358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1052585005359 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1052585005360 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1052585005361 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1052585005362 RNA binding site [nucleotide binding]; other site 1052585005363 active site 1052585005364 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1052585005365 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 1052585005366 active site 1052585005367 Riboflavin kinase; Region: Flavokinase; smart00904 1052585005368 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1052585005369 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1052585005370 RNase E interface [polypeptide binding]; other site 1052585005371 trimer interface [polypeptide binding]; other site 1052585005372 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1052585005373 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1052585005374 RNase E interface [polypeptide binding]; other site 1052585005375 trimer interface [polypeptide binding]; other site 1052585005376 active site 1052585005377 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1052585005378 putative nucleic acid binding region [nucleotide binding]; other site 1052585005379 G-X-X-G motif; other site 1052585005380 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1052585005381 RNA binding site [nucleotide binding]; other site 1052585005382 domain interface; other site 1052585005383 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1052585005384 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1052585005385 NodB motif; other site 1052585005386 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052585005387 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052585005388 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052585005389 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1052585005390 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1052585005391 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1052585005392 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 1052585005393 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1052585005394 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1052585005395 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1052585005396 aspartate kinase I; Reviewed; Region: PRK08210 1052585005397 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1052585005398 putative catalytic residues [active] 1052585005399 putative nucleotide binding site [chemical binding]; other site 1052585005400 putative aspartate binding site [chemical binding]; other site 1052585005401 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1052585005402 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1052585005403 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1052585005404 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1052585005405 dimer interface [polypeptide binding]; other site 1052585005406 active site 1052585005407 catalytic residue [active] 1052585005408 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1052585005409 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052585005410 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1052585005411 Clp protease; Region: CLP_protease; pfam00574 1052585005412 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1052585005413 active site 1052585005414 YlzJ-like protein; Region: YlzJ; pfam14035 1052585005415 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1052585005416 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1052585005417 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052585005418 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1052585005419 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052585005420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585005421 DNA-binding site [nucleotide binding]; DNA binding site 1052585005422 UTRA domain; Region: UTRA; pfam07702 1052585005423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585005424 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585005425 putative substrate translocation pore; other site 1052585005426 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052585005427 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052585005428 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052585005429 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052585005430 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052585005431 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1052585005432 classical (c) SDRs; Region: SDR_c; cd05233 1052585005433 NAD(P) binding site [chemical binding]; other site 1052585005434 active site 1052585005435 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1052585005436 ACT domain; Region: ACT; pfam01842 1052585005437 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1052585005438 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1052585005439 Helix-turn-helix domain; Region: HTH_25; pfam13413 1052585005440 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1052585005441 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1052585005442 competence damage-inducible protein A; Provisional; Region: PRK00549 1052585005443 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1052585005444 putative MPT binding site; other site 1052585005445 competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199 1052585005446 recombinase A; Provisional; Region: recA; PRK09354 1052585005447 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1052585005448 hexamer interface [polypeptide binding]; other site 1052585005449 Walker A motif; other site 1052585005450 ATP binding site [chemical binding]; other site 1052585005451 Walker B motif; other site 1052585005452 Beta-lactamase; Region: Beta-lactamase; pfam00144 1052585005453 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052585005454 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1052585005455 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1052585005456 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052585005457 Zn2+ binding site [ion binding]; other site 1052585005458 Mg2+ binding site [ion binding]; other site 1052585005459 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1052585005460 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052585005461 putative active site [active] 1052585005462 metal binding site [ion binding]; metal-binding site 1052585005463 homodimer binding site [polypeptide binding]; other site 1052585005464 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1052585005465 Threonine dehydrogenase; Region: TDH; cd05281 1052585005466 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 1052585005467 structural Zn binding site [ion binding]; other site 1052585005468 catalytic Zn binding site [ion binding]; other site 1052585005469 tetramer interface [polypeptide binding]; other site 1052585005470 NADP binding site [chemical binding]; other site 1052585005471 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1052585005472 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1052585005473 substrate-cofactor binding pocket; other site 1052585005474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585005475 catalytic residue [active] 1052585005476 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1052585005477 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1052585005478 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585005479 FeS/SAM binding site; other site 1052585005480 TRAM domain; Region: TRAM; pfam01938 1052585005481 Predicted membrane protein [Function unknown]; Region: COG4550 1052585005482 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1052585005483 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1052585005484 MutS domain I; Region: MutS_I; pfam01624 1052585005485 MutS domain II; Region: MutS_II; pfam05188 1052585005486 MutS domain III; Region: MutS_III; pfam05192 1052585005487 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1052585005488 Walker A/P-loop; other site 1052585005489 ATP binding site [chemical binding]; other site 1052585005490 Q-loop/lid; other site 1052585005491 ABC transporter signature motif; other site 1052585005492 Walker B; other site 1052585005493 D-loop; other site 1052585005494 H-loop/switch region; other site 1052585005495 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1052585005496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585005497 ATP binding site [chemical binding]; other site 1052585005498 Mg2+ binding site [ion binding]; other site 1052585005499 G-X-G motif; other site 1052585005500 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1052585005501 ATP binding site [chemical binding]; other site 1052585005502 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1052585005503 Regulatory protein YrvL; Region: YrvL; pfam14184 1052585005504 transcriptional regulator BetI; Validated; Region: PRK00767 1052585005505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585005506 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1052585005507 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585005508 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1052585005509 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052585005510 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052585005511 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1052585005512 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1052585005513 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052585005514 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1052585005515 FMN binding site [chemical binding]; other site 1052585005516 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1052585005517 substrate binding site [chemical binding]; other site 1052585005518 putative catalytic residue [active] 1052585005519 acyl carrier protein; Validated; Region: PRK07117 1052585005520 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1052585005521 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1052585005522 dimer interface [polypeptide binding]; other site 1052585005523 active site 1052585005524 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1052585005525 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1052585005526 dimer interface [polypeptide binding]; other site 1052585005527 active site 1052585005528 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585005529 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052585005530 substrate binding site [chemical binding]; other site 1052585005531 oxyanion hole (OAH) forming residues; other site 1052585005532 trimer interface [polypeptide binding]; other site 1052585005533 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052585005534 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585005535 substrate binding site [chemical binding]; other site 1052585005536 oxyanion hole (OAH) forming residues; other site 1052585005537 trimer interface [polypeptide binding]; other site 1052585005538 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 1052585005539 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1052585005540 acyl-activating enzyme (AAE) consensus motif; other site 1052585005541 putative AMP binding site [chemical binding]; other site 1052585005542 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005543 Condensation domain; Region: Condensation; pfam00668 1052585005544 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005545 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005546 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1052585005547 acyl-activating enzyme (AAE) consensus motif; other site 1052585005548 AMP binding site [chemical binding]; other site 1052585005549 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005550 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005551 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005552 active site 1052585005553 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005554 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005555 KR domain; Region: KR; pfam08659 1052585005556 putative NADP binding site [chemical binding]; other site 1052585005557 active site 1052585005558 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005559 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052585005560 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005561 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005562 active site 1052585005563 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005564 putative NADP binding site [chemical binding]; other site 1052585005565 active site 1052585005566 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005567 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005568 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005569 active site 1052585005570 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005571 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005572 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005573 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005574 active site 1052585005575 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005576 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005577 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052585005578 putative NADP binding site [chemical binding]; other site 1052585005579 active site 1052585005580 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052585005581 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005582 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005583 active site 1052585005584 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052585005585 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052585005586 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005587 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005588 active site 1052585005589 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005590 putative NADP binding site [chemical binding]; other site 1052585005591 active site 1052585005592 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005593 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005594 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005595 active site 1052585005596 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052585005597 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005598 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005599 active site 1052585005600 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005601 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005602 putative NADP binding site [chemical binding]; other site 1052585005603 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052585005604 active site 1052585005605 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1052585005606 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052585005607 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005608 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005609 active site 1052585005610 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005611 putative NADP binding site [chemical binding]; other site 1052585005612 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052585005613 active site 1052585005614 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005615 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005616 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005617 active site 1052585005618 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005619 Condensation domain; Region: Condensation; pfam00668 1052585005620 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005621 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005622 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052585005623 acyl-activating enzyme (AAE) consensus motif; other site 1052585005624 AMP binding site [chemical binding]; other site 1052585005625 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005626 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005627 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005628 active site 1052585005629 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005630 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005631 putative NADP binding site [chemical binding]; other site 1052585005632 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052585005633 active site 1052585005634 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052585005635 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005636 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005637 active site 1052585005638 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005639 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005640 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052585005641 putative NADP binding site [chemical binding]; other site 1052585005642 active site 1052585005643 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052585005644 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005645 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005646 active site 1052585005647 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005648 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005649 putative NADP binding site [chemical binding]; other site 1052585005650 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052585005651 active site 1052585005652 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1052585005653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585005654 S-adenosylmethionine binding site [chemical binding]; other site 1052585005655 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052585005656 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005657 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005658 active site 1052585005659 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005660 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005661 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005662 active site 1052585005663 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005664 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1052585005665 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052585005666 Cytochrome P450; Region: p450; cl12078 1052585005667 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052585005668 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1052585005669 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1052585005670 active site 1052585005671 catalytic triad [active] 1052585005672 Phage-related replication protein [General function prediction only]; Region: COG4195 1052585005673 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1052585005674 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052585005675 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1052585005676 YmaF family; Region: YmaF; pfam12788 1052585005677 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1052585005678 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1052585005679 bacterial Hfq-like; Region: Hfq; cd01716 1052585005680 hexamer interface [polypeptide binding]; other site 1052585005681 Sm1 motif; other site 1052585005682 RNA binding site [nucleotide binding]; other site 1052585005683 Sm2 motif; other site 1052585005684 YmzC-like protein; Region: YmzC; pfam14157 1052585005685 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1052585005686 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1052585005687 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1052585005688 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1052585005689 active site 1052585005690 dimer interface [polypeptide binding]; other site 1052585005691 catalytic residues [active] 1052585005692 effector binding site; other site 1052585005693 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1052585005694 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1052585005695 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1052585005696 dimer interface [polypeptide binding]; other site 1052585005697 putative radical transfer pathway; other site 1052585005698 diiron center [ion binding]; other site 1052585005699 tyrosyl radical; other site 1052585005700 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1052585005701 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1052585005702 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052585005703 active site 1052585005704 metal binding site [ion binding]; metal-binding site 1052585005705 Sporulation related domain; Region: SPOR; pfam05036 1052585005706 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1052585005707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585005708 Walker A motif; other site 1052585005709 ATP binding site [chemical binding]; other site 1052585005710 Walker B motif; other site 1052585005711 arginine finger; other site 1052585005712 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1052585005713 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1052585005714 HflX GTPase family; Region: HflX; cd01878 1052585005715 G1 box; other site 1052585005716 GTP/Mg2+ binding site [chemical binding]; other site 1052585005717 Switch I region; other site 1052585005718 G2 box; other site 1052585005719 G3 box; other site 1052585005720 Switch II region; other site 1052585005721 G4 box; other site 1052585005722 G5 box; other site 1052585005723 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1052585005724 Aluminium resistance protein; Region: Alum_res; pfam06838 1052585005725 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1052585005726 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052585005727 DNA binding residues [nucleotide binding] 1052585005728 putative dimer interface [polypeptide binding]; other site 1052585005729 glutamine synthetase, type I; Region: GlnA; TIGR00653 1052585005730 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1052585005731 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1052585005732 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1052585005733 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1052585005734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585005735 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1052585005736 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1052585005737 inhibitor binding site; inhibition site 1052585005738 active site 1052585005739 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1052585005740 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1052585005741 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052585005742 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052585005743 nucleotide binding site [chemical binding]; other site 1052585005744 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1052585005745 xylose isomerase; Provisional; Region: PRK05474 1052585005746 xylose isomerase; Region: xylose_isom_A; TIGR02630 1052585005747 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1052585005748 N- and C-terminal domain interface [polypeptide binding]; other site 1052585005749 D-xylulose kinase; Region: XylB; TIGR01312 1052585005750 active site 1052585005751 MgATP binding site [chemical binding]; other site 1052585005752 catalytic site [active] 1052585005753 metal binding site [ion binding]; metal-binding site 1052585005754 xylulose binding site [chemical binding]; other site 1052585005755 homodimer interface [polypeptide binding]; other site 1052585005756 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1052585005757 Staphylococcal nuclease homologues; Region: SNc; smart00318 1052585005758 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1052585005759 Catalytic site; other site 1052585005760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585005761 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052585005762 putative substrate translocation pore; other site 1052585005763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585005764 alanine racemase; Region: alr; TIGR00492 1052585005765 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1052585005766 active site 1052585005767 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052585005768 dimer interface [polypeptide binding]; other site 1052585005769 substrate binding site [chemical binding]; other site 1052585005770 catalytic residues [active] 1052585005771 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1052585005772 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1052585005773 trimer interface [polypeptide binding]; other site 1052585005774 active site 1052585005775 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1052585005776 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1052585005777 dimerization interface [polypeptide binding]; other site 1052585005778 active site 1052585005779 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1052585005780 putative binding site; other site 1052585005781 putative dimer interface [polypeptide binding]; other site 1052585005782 YoqO-like protein; Region: YoqO; pfam14037 1052585005783 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1052585005784 putative hydrophobic ligand binding site [chemical binding]; other site 1052585005785 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1052585005786 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1052585005787 Chromate transporter; Region: Chromate_transp; pfam02417 1052585005788 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052585005789 Spore germination protein; Region: Spore_permease; pfam03845 1052585005790 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052585005791 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052585005792 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1052585005793 YndJ-like protein; Region: YndJ; pfam14158 1052585005794 Protein of unknown function (DUF1180); Region: DUF1180; pfam06679 1052585005795 Phage-related replication protein [General function prediction only]; Region: COG4195 1052585005796 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1052585005797 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1052585005798 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 1052585005799 putative active site [active] 1052585005800 putative Mg binding site [ion binding]; other site 1052585005801 LexA repressor; Validated; Region: PRK00215 1052585005802 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585005803 putative DNA binding site [nucleotide binding]; other site 1052585005804 putative Zn2+ binding site [ion binding]; other site 1052585005805 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1052585005806 Catalytic site [active] 1052585005807 cell division suppressor protein YneA; Provisional; Region: PRK14125 1052585005808 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585005809 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1052585005810 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1052585005811 catalytic residues [active] 1052585005812 catalytic nucleophile [active] 1052585005813 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1052585005814 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1052585005815 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1052585005816 TPP-binding site [chemical binding]; other site 1052585005817 dimer interface [polypeptide binding]; other site 1052585005818 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1052585005819 PYR/PP interface [polypeptide binding]; other site 1052585005820 dimer interface [polypeptide binding]; other site 1052585005821 TPP binding site [chemical binding]; other site 1052585005822 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052585005823 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1052585005824 hypothetical protein; Provisional; Region: PRK01844 1052585005825 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052585005826 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1052585005827 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1052585005828 Response regulator receiver domain; Region: Response_reg; pfam00072 1052585005829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585005830 active site 1052585005831 phosphorylation site [posttranslational modification] 1052585005832 intermolecular recognition site; other site 1052585005833 dimerization interface [polypeptide binding]; other site 1052585005834 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1052585005835 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1052585005836 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1052585005837 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1052585005838 putative dimer interface [polypeptide binding]; other site 1052585005839 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1052585005840 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1052585005841 aconitate hydratase; Validated; Region: PRK09277 1052585005842 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1052585005843 substrate binding site [chemical binding]; other site 1052585005844 ligand binding site [chemical binding]; other site 1052585005845 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1052585005846 substrate binding site [chemical binding]; other site 1052585005847 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1052585005848 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052585005849 catalytic residues [active] 1052585005850 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1052585005851 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1052585005852 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1052585005853 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1052585005854 active site 1052585005855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1052585005856 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1052585005857 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1052585005858 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1052585005859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585005860 ATP binding site [chemical binding]; other site 1052585005861 Mg2+ binding site [ion binding]; other site 1052585005862 G-X-G motif; other site 1052585005863 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1052585005864 anchoring element; other site 1052585005865 dimer interface [polypeptide binding]; other site 1052585005866 ATP binding site [chemical binding]; other site 1052585005867 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1052585005868 active site 1052585005869 putative metal-binding site [ion binding]; other site 1052585005870 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1052585005871 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1052585005872 active site 1052585005873 primary dimer interface [polypeptide binding]; other site 1052585005874 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585005875 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585005876 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585005877 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585005878 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052585005879 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1052585005880 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1052585005881 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1052585005882 Cellulose binding domain; Region: CBM_3; pfam00942 1052585005883 Predicted membrane protein [Function unknown]; Region: COG2246 1052585005884 GtrA-like protein; Region: GtrA; pfam04138 1052585005885 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052585005886 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1052585005887 active site 1052585005888 tetramer interface; other site 1052585005889 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1052585005890 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052585005891 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1052585005892 DHH family; Region: DHH; pfam01368 1052585005893 DHHA1 domain; Region: DHHA1; pfam02272 1052585005894 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1052585005895 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1052585005896 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1052585005897 enoyl-CoA hydratase; Provisional; Region: PRK07657 1052585005898 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585005899 substrate binding site [chemical binding]; other site 1052585005900 oxyanion hole (OAH) forming residues; other site 1052585005901 trimer interface [polypeptide binding]; other site 1052585005902 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1052585005903 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1052585005904 active site 1052585005905 catalytic residues [active] 1052585005906 metal binding site [ion binding]; metal-binding site 1052585005907 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1052585005908 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052585005909 carboxyltransferase (CT) interaction site; other site 1052585005910 biotinylation site [posttranslational modification]; other site 1052585005911 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1052585005912 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585005913 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1052585005914 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1052585005915 AMP-binding domain protein; Validated; Region: PRK08315 1052585005916 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052585005917 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1052585005918 acyl-activating enzyme (AAE) consensus motif; other site 1052585005919 putative AMP binding site [chemical binding]; other site 1052585005920 putative active site [active] 1052585005921 putative CoA binding site [chemical binding]; other site 1052585005922 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052585005923 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1052585005924 active site 1052585005925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585005926 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052585005927 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052585005928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1052585005929 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1052585005930 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1052585005931 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052585005932 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1052585005933 acyl-activating enzyme (AAE) consensus motif; other site 1052585005934 AMP binding site [chemical binding]; other site 1052585005935 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005936 Condensation domain; Region: Condensation; pfam00668 1052585005937 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005938 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052585005939 Condensation domain; Region: Condensation; pfam00668 1052585005940 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005941 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052585005942 acyl-activating enzyme (AAE) consensus motif; other site 1052585005943 AMP binding site [chemical binding]; other site 1052585005944 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005945 Thioesterase domain; Region: Thioesterase; pfam00975 1052585005946 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005947 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052585005948 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1052585005949 acyl-activating enzyme (AAE) consensus motif; other site 1052585005950 AMP binding site [chemical binding]; other site 1052585005951 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005952 Condensation domain; Region: Condensation; pfam00668 1052585005953 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005954 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052585005955 Condensation domain; Region: Condensation; pfam00668 1052585005956 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005957 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052585005958 acyl-activating enzyme (AAE) consensus motif; other site 1052585005959 AMP binding site [chemical binding]; other site 1052585005960 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005961 Condensation domain; Region: Condensation; pfam00668 1052585005962 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052585005963 Condensation domain; Region: Condensation; pfam00668 1052585005964 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005965 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052585005966 acyl-activating enzyme (AAE) consensus motif; other site 1052585005967 AMP binding site [chemical binding]; other site 1052585005968 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005969 Condensation domain; Region: Condensation; pfam00668 1052585005970 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005971 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005972 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052585005973 acyl-activating enzyme (AAE) consensus motif; other site 1052585005974 AMP binding site [chemical binding]; other site 1052585005975 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005976 Condensation domain; Region: Condensation; pfam00668 1052585005977 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005978 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005979 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1052585005980 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 1052585005981 acyl-activating enzyme (AAE) consensus motif; other site 1052585005982 putative AMP binding site [chemical binding]; other site 1052585005983 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005984 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005985 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005986 active site 1052585005987 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005988 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1052585005989 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585005990 inhibitor-cofactor binding pocket; inhibition site 1052585005991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585005992 catalytic residue [active] 1052585005993 Condensation domain; Region: Condensation; pfam00668 1052585005994 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005995 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005996 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585005997 Condensation domain; Region: Condensation; pfam00668 1052585005998 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005999 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585006000 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052585006001 acyl-activating enzyme (AAE) consensus motif; other site 1052585006002 AMP binding site [chemical binding]; other site 1052585006003 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585006004 Condensation domain; Region: Condensation; pfam00668 1052585006005 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585006006 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585006007 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1052585006008 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052585006009 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1052585006010 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1052585006011 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1052585006012 active site 1052585006013 catalytic residues [active] 1052585006014 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052585006015 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1052585006016 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1052585006017 Int/Topo IB signature motif; other site 1052585006018 Helix-turn-helix domain; Region: HTH_17; cl17695 1052585006019 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1052585006020 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1052585006021 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585006022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585006023 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1052585006024 putative dimerization interface [polypeptide binding]; other site 1052585006025 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1052585006026 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1052585006027 NAD(P) binding site [chemical binding]; other site 1052585006028 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1052585006029 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1052585006030 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1052585006031 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1052585006032 active site 1052585006033 dimer interface [polypeptide binding]; other site 1052585006034 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1052585006035 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1052585006036 active site 1052585006037 FMN binding site [chemical binding]; other site 1052585006038 substrate binding site [chemical binding]; other site 1052585006039 3Fe-4S cluster binding site [ion binding]; other site 1052585006040 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1052585006041 domain interface; other site 1052585006042 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585006043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585006044 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1052585006045 putative dimerization interface [polypeptide binding]; other site 1052585006046 gamma-glutamyl kinase; Provisional; Region: PRK13402 1052585006047 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1052585006048 nucleotide binding site [chemical binding]; other site 1052585006049 homotetrameric interface [polypeptide binding]; other site 1052585006050 putative phosphate binding site [ion binding]; other site 1052585006051 putative allosteric binding site; other site 1052585006052 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1052585006053 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1052585006054 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1052585006055 Replication terminator protein; Region: RTP; pfam02334 1052585006056 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052585006057 Cytochrome P450; Region: p450; cl12078 1052585006058 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1052585006059 classical (c) SDRs; Region: SDR_c; cd05233 1052585006060 NAD(P) binding site [chemical binding]; other site 1052585006061 active site 1052585006062 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1052585006063 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1052585006064 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1052585006065 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585006066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585006067 Walker A/P-loop; other site 1052585006068 ATP binding site [chemical binding]; other site 1052585006069 Q-loop/lid; other site 1052585006070 ABC transporter signature motif; other site 1052585006071 Walker B; other site 1052585006072 D-loop; other site 1052585006073 H-loop/switch region; other site 1052585006074 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585006075 MarR family; Region: MarR_2; pfam12802 1052585006076 MarR family; Region: MarR_2; cl17246 1052585006077 polyol permease family; Region: 2A0118; TIGR00897 1052585006078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585006079 putative substrate translocation pore; other site 1052585006080 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1052585006081 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 1052585006082 putative N- and C-terminal domain interface [polypeptide binding]; other site 1052585006083 putative active site [active] 1052585006084 putative MgATP binding site [chemical binding]; other site 1052585006085 catalytic site [active] 1052585006086 metal binding site [ion binding]; metal-binding site 1052585006087 carbohydrate binding site [chemical binding]; other site 1052585006088 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1052585006089 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1052585006090 putative ligand binding site [chemical binding]; other site 1052585006091 putative NAD binding site [chemical binding]; other site 1052585006092 catalytic site [active] 1052585006093 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1052585006094 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1052585006095 putative [4Fe-4S] binding site [ion binding]; other site 1052585006096 putative molybdopterin cofactor binding site [chemical binding]; other site 1052585006097 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1052585006098 putative molybdopterin cofactor binding site; other site 1052585006099 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1052585006100 CHASE3 domain; Region: CHASE3; cl05000 1052585006101 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585006102 dimerization interface [polypeptide binding]; other site 1052585006103 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585006104 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585006105 dimer interface [polypeptide binding]; other site 1052585006106 putative CheW interface [polypeptide binding]; other site 1052585006107 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1052585006108 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1052585006109 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 1052585006110 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1052585006111 Predicted membrane protein [Function unknown]; Region: COG3619 1052585006112 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1052585006113 Amb_all domain; Region: Amb_all; smart00656 1052585006114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006115 NAD(P) binding site [chemical binding]; other site 1052585006116 active site 1052585006117 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 1052585006118 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1052585006119 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1052585006120 Cupin; Region: Cupin_1; smart00835 1052585006121 Cupin; Region: Cupin_1; smart00835 1052585006122 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1052585006123 VanW like protein; Region: VanW; pfam04294 1052585006124 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1052585006125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585006126 salt bridge; other site 1052585006127 non-specific DNA binding site [nucleotide binding]; other site 1052585006128 sequence-specific DNA binding site [nucleotide binding]; other site 1052585006129 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1052585006130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585006131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585006132 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585006133 dimerization interface [polypeptide binding]; other site 1052585006134 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052585006135 EamA-like transporter family; Region: EamA; pfam00892 1052585006136 EamA-like transporter family; Region: EamA; pfam00892 1052585006137 CAAX protease self-immunity; Region: Abi; pfam02517 1052585006138 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1052585006139 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1052585006140 conserved cys residue [active] 1052585006141 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1052585006142 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1052585006143 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1052585006144 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1052585006145 DinB family; Region: DinB; pfam05163 1052585006146 DinB superfamily; Region: DinB_2; pfam12867 1052585006147 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052585006148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585006149 Coenzyme A binding pocket [chemical binding]; other site 1052585006150 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1052585006151 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585006152 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1052585006153 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1052585006154 active site 1052585006155 active site 1052585006156 catalytic residues [active] 1052585006157 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052585006158 Cytochrome P450; Region: p450; cl12078 1052585006159 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052585006160 Coenzyme A binding pocket [chemical binding]; other site 1052585006161 LysE type translocator; Region: LysE; cl00565 1052585006162 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1052585006163 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 1052585006164 predicted active site [active] 1052585006165 catalytic triad [active] 1052585006166 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 1052585006167 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1052585006168 phosphate binding site [ion binding]; other site 1052585006169 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585006170 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585006171 DNA-binding site [nucleotide binding]; DNA binding site 1052585006172 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585006173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585006174 homodimer interface [polypeptide binding]; other site 1052585006175 catalytic residue [active] 1052585006176 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052585006177 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1052585006178 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052585006179 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1052585006180 putative substrate binding site [chemical binding]; other site 1052585006181 putative ATP binding site [chemical binding]; other site 1052585006182 maltose O-acetyltransferase; Provisional; Region: PRK10092 1052585006183 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1052585006184 active site 1052585006185 substrate binding site [chemical binding]; other site 1052585006186 trimer interface [polypeptide binding]; other site 1052585006187 CoA binding site [chemical binding]; other site 1052585006188 DNA polymerase IV; Reviewed; Region: PRK03103 1052585006189 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052585006190 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1052585006191 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1052585006192 dimer interface [polypeptide binding]; other site 1052585006193 putative tRNA-binding site [nucleotide binding]; other site 1052585006194 Cupin domain; Region: Cupin_2; pfam07883 1052585006195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585006196 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585006197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585006198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585006199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585006200 WHG domain; Region: WHG; pfam13305 1052585006201 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052585006202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1052585006203 Predicted transcriptional regulator [Transcription]; Region: COG2378 1052585006204 HTH domain; Region: HTH_11; pfam08279 1052585006205 WYL domain; Region: WYL; pfam13280 1052585006206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585006207 dimerization interface [polypeptide binding]; other site 1052585006208 putative DNA binding site [nucleotide binding]; other site 1052585006209 putative Zn2+ binding site [ion binding]; other site 1052585006210 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1052585006211 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1052585006212 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052585006213 catalytic residue [active] 1052585006214 Predicted membrane protein [Function unknown]; Region: COG2322 1052585006215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052585006216 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1052585006217 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1052585006218 putative di-iron ligands [ion binding]; other site 1052585006219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585006220 Histidine kinase; Region: HisKA_3; pfam07730 1052585006221 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1052585006222 ATP binding site [chemical binding]; other site 1052585006223 Mg2+ binding site [ion binding]; other site 1052585006224 G-X-G motif; other site 1052585006225 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585006226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585006227 active site 1052585006228 phosphorylation site [posttranslational modification] 1052585006229 intermolecular recognition site; other site 1052585006230 dimerization interface [polypeptide binding]; other site 1052585006231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585006232 DNA binding residues [nucleotide binding] 1052585006233 dimerization interface [polypeptide binding]; other site 1052585006234 putative transporter; Provisional; Region: PRK10484 1052585006235 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 1052585006236 Na binding site [ion binding]; other site 1052585006237 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585006238 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585006239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1052585006240 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1052585006241 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585006242 ATP binding site [chemical binding]; other site 1052585006243 putative Mg++ binding site [ion binding]; other site 1052585006244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585006245 nucleotide binding region [chemical binding]; other site 1052585006246 ATP-binding site [chemical binding]; other site 1052585006247 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1052585006248 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1052585006249 azoreductase; Provisional; Region: PRK13556 1052585006250 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1052585006251 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1052585006252 pentamer interface [polypeptide binding]; other site 1052585006253 dodecaamer interface [polypeptide binding]; other site 1052585006254 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1052585006255 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052585006256 NAD(P) binding site [chemical binding]; other site 1052585006257 catalytic residues [active] 1052585006258 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1052585006259 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1052585006260 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1052585006261 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1052585006262 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1052585006263 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1052585006264 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1052585006265 Na2 binding site [ion binding]; other site 1052585006266 putative substrate binding site 1 [chemical binding]; other site 1052585006267 Na binding site 1 [ion binding]; other site 1052585006268 putative substrate binding site 2 [chemical binding]; other site 1052585006269 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1052585006270 Sodium Bile acid symporter family; Region: SBF; pfam01758 1052585006271 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1052585006272 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052585006273 E3 interaction surface; other site 1052585006274 lipoyl attachment site [posttranslational modification]; other site 1052585006275 e3 binding domain; Region: E3_binding; pfam02817 1052585006276 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1052585006277 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1052585006278 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1052585006279 TPP-binding site [chemical binding]; other site 1052585006280 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1052585006281 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1052585006282 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1052585006283 metal ion-dependent adhesion site (MIDAS); other site 1052585006284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585006285 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052585006286 Walker A motif; other site 1052585006287 ATP binding site [chemical binding]; other site 1052585006288 Walker B motif; other site 1052585006289 arginine finger; other site 1052585006290 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1052585006291 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1052585006292 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 1052585006293 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1052585006294 E-class dimer interface [polypeptide binding]; other site 1052585006295 P-class dimer interface [polypeptide binding]; other site 1052585006296 active site 1052585006297 Cu2+ binding site [ion binding]; other site 1052585006298 Zn2+ binding site [ion binding]; other site 1052585006299 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585006300 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585006301 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585006302 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1052585006303 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585006304 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052585006305 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052585006306 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052585006307 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1052585006308 active site 1052585006309 TDP-binding site; other site 1052585006310 acceptor substrate-binding pocket; other site 1052585006311 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1052585006312 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1052585006313 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052585006314 multidrug efflux protein; Reviewed; Region: PRK01766 1052585006315 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1052585006316 cation binding site [ion binding]; other site 1052585006317 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585006318 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1052585006319 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1052585006320 rarD protein; Region: rarD; TIGR00688 1052585006321 EamA-like transporter family; Region: EamA; pfam00892 1052585006322 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1052585006323 GntP family permease; Region: GntP_permease; pfam02447 1052585006324 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1052585006325 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052585006326 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585006327 dimerization interface [polypeptide binding]; other site 1052585006328 putative DNA binding site [nucleotide binding]; other site 1052585006329 putative Zn2+ binding site [ion binding]; other site 1052585006330 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052585006331 dimer interface [polypeptide binding]; other site 1052585006332 FMN binding site [chemical binding]; other site 1052585006333 Predicted esterase [General function prediction only]; Region: COG0400 1052585006334 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052585006335 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585006336 Zn binding site [ion binding]; other site 1052585006337 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052585006338 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585006339 Zn binding site [ion binding]; other site 1052585006340 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1052585006341 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1052585006342 Na binding site [ion binding]; other site 1052585006343 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1052585006344 C-terminal peptidase (prc); Region: prc; TIGR00225 1052585006345 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1052585006346 protein binding site [polypeptide binding]; other site 1052585006347 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1052585006348 Catalytic dyad [active] 1052585006349 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052585006350 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052585006351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585006352 S-adenosylmethionine binding site [chemical binding]; other site 1052585006353 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1052585006354 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1052585006355 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1052585006356 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1052585006357 YodL-like; Region: YodL; pfam14191 1052585006358 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1052585006359 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1052585006360 active site 1052585006361 YozD-like protein; Region: YozD; pfam14162 1052585006362 hypothetical protein; Provisional; Region: PRK13672 1052585006363 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1052585006364 Zn binding site [ion binding]; other site 1052585006365 toxin interface [polypeptide binding]; other site 1052585006366 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1052585006367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585006368 FeS/SAM binding site; other site 1052585006369 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1052585006370 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1052585006371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585006372 Coenzyme A binding pocket [chemical binding]; other site 1052585006373 acetylornithine deacetylase; Validated; Region: PRK06915 1052585006374 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1052585006375 metal binding site [ion binding]; metal-binding site 1052585006376 dimer interface [polypeptide binding]; other site 1052585006377 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1052585006378 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1052585006379 hypothetical protein; Provisional; Region: PRK06917 1052585006380 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585006381 inhibitor-cofactor binding pocket; inhibition site 1052585006382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585006383 catalytic residue [active] 1052585006384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585006385 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052585006386 Coenzyme A binding pocket [chemical binding]; other site 1052585006387 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052585006388 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585006389 active site 1052585006390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1052585006391 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1052585006392 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1052585006393 Phytase; Region: Phytase; cl17685 1052585006394 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1052585006395 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1052585006396 NAD(P) binding site [chemical binding]; other site 1052585006397 homodimer interface [polypeptide binding]; other site 1052585006398 substrate binding site [chemical binding]; other site 1052585006399 active site 1052585006400 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1052585006401 SelR domain; Region: SelR; pfam01641 1052585006402 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1052585006403 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585006404 MarR family; Region: MarR; pfam01047 1052585006405 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052585006406 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1052585006407 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 1052585006408 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1052585006409 active site 1052585006410 catalytic triad [active] 1052585006411 oxyanion hole [active] 1052585006412 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1052585006413 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1052585006414 Cu(I) binding site [ion binding]; other site 1052585006415 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1052585006416 threonine dehydratase; Validated; Region: PRK08639 1052585006417 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1052585006418 tetramer interface [polypeptide binding]; other site 1052585006419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585006420 catalytic residue [active] 1052585006421 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1052585006422 putative Ile/Val binding site [chemical binding]; other site 1052585006423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1052585006424 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1052585006425 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1052585006426 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1052585006427 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1052585006428 putative acyl-acceptor binding pocket; other site 1052585006429 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1052585006430 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1052585006431 folate binding site [chemical binding]; other site 1052585006432 NADP+ binding site [chemical binding]; other site 1052585006433 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1052585006434 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1052585006435 dimerization interface [polypeptide binding]; other site 1052585006436 active site 1052585006437 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1052585006438 tetramer interfaces [polypeptide binding]; other site 1052585006439 binuclear metal-binding site [ion binding]; other site 1052585006440 YpjP-like protein; Region: YpjP; pfam14005 1052585006441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585006442 S-adenosylmethionine binding site [chemical binding]; other site 1052585006443 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1052585006444 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1052585006445 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1052585006446 Virulence factor; Region: Virulence_fact; pfam13769 1052585006447 HEAT repeats; Region: HEAT_2; pfam13646 1052585006448 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1052585006449 HEAT repeats; Region: HEAT_2; pfam13646 1052585006450 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1052585006451 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1052585006452 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052585006453 Zn2+ binding site [ion binding]; other site 1052585006454 Mg2+ binding site [ion binding]; other site 1052585006455 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1052585006456 catalytic residues [active] 1052585006457 dimer interface [polypeptide binding]; other site 1052585006458 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1052585006459 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1052585006460 conserved cys residue [active] 1052585006461 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1052585006462 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1052585006463 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052585006464 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1052585006465 DNA-binding site [nucleotide binding]; DNA binding site 1052585006466 RNA-binding motif; other site 1052585006467 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1052585006468 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1052585006469 hypothetical protein; Validated; Region: PRK07708 1052585006470 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1052585006471 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052585006472 active site 1052585006473 conserved hypothetical integral membrane protein; Region: TIGR00697 1052585006474 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1052585006475 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052585006476 active site 1052585006477 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1052585006478 5'-3' exonuclease; Region: 53EXOc; smart00475 1052585006479 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1052585006480 active site 1052585006481 metal binding site 1 [ion binding]; metal-binding site 1052585006482 putative 5' ssDNA interaction site; other site 1052585006483 metal binding site 3; metal-binding site 1052585006484 metal binding site 2 [ion binding]; metal-binding site 1052585006485 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1052585006486 putative DNA binding site [nucleotide binding]; other site 1052585006487 putative metal binding site [ion binding]; other site 1052585006488 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1052585006489 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1052585006490 Dynamin family; Region: Dynamin_N; pfam00350 1052585006491 G1 box; other site 1052585006492 GTP/Mg2+ binding site [chemical binding]; other site 1052585006493 G2 box; other site 1052585006494 Switch I region; other site 1052585006495 G3 box; other site 1052585006496 Switch II region; other site 1052585006497 G4 box; other site 1052585006498 G5 box; other site 1052585006499 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1052585006500 G1 box; other site 1052585006501 GTP/Mg2+ binding site [chemical binding]; other site 1052585006502 Dynamin family; Region: Dynamin_N; pfam00350 1052585006503 G2 box; other site 1052585006504 Switch I region; other site 1052585006505 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1052585006506 G3 box; other site 1052585006507 Switch II region; other site 1052585006508 GTP/Mg2+ binding site [chemical binding]; other site 1052585006509 G4 box; other site 1052585006510 G5 box; other site 1052585006511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1052585006512 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1052585006513 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1052585006514 malonyl-CoA binding site [chemical binding]; other site 1052585006515 dimer interface [polypeptide binding]; other site 1052585006516 active site 1052585006517 product binding site; other site 1052585006518 xanthine permease; Region: pbuX; TIGR03173 1052585006519 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585006520 active site 1052585006521 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1052585006522 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1052585006523 active site 1052585006524 Zn binding site [ion binding]; other site 1052585006525 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1052585006526 Entner-Doudoroff aldolase; Region: eda; TIGR01182 1052585006527 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1052585006528 active site 1052585006529 intersubunit interface [polypeptide binding]; other site 1052585006530 catalytic residue [active] 1052585006531 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052585006532 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1052585006533 substrate binding site [chemical binding]; other site 1052585006534 ATP binding site [chemical binding]; other site 1052585006535 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585006536 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585006537 DNA binding site [nucleotide binding] 1052585006538 domain linker motif; other site 1052585006539 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1052585006540 putative dimerization interface [polypeptide binding]; other site 1052585006541 putative ligand binding site [chemical binding]; other site 1052585006542 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1052585006543 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1052585006544 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1052585006545 NADP binding site [chemical binding]; other site 1052585006546 homodimer interface [polypeptide binding]; other site 1052585006547 active site 1052585006548 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1052585006549 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1052585006550 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1052585006551 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1052585006552 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1052585006553 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1052585006554 cell division protein GpsB; Provisional; Region: PRK14127 1052585006555 DivIVA domain; Region: DivI1A_domain; TIGR03544 1052585006556 hypothetical protein; Provisional; Region: PRK13660 1052585006557 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1052585006558 RNase_H superfamily; Region: RNase_H_2; pfam13482 1052585006559 active site 1052585006560 substrate binding site [chemical binding]; other site 1052585006561 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1052585006562 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585006563 ATP binding site [chemical binding]; other site 1052585006564 putative Mg++ binding site [ion binding]; other site 1052585006565 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585006566 nucleotide binding region [chemical binding]; other site 1052585006567 ATP-binding site [chemical binding]; other site 1052585006568 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1052585006569 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052585006570 HPr interaction site; other site 1052585006571 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585006572 active site 1052585006573 phosphorylation site [posttranslational modification] 1052585006574 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1052585006575 YppG-like protein; Region: YppG; pfam14179 1052585006576 YppF-like protein; Region: YppF; pfam14178 1052585006577 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1052585006578 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1052585006579 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1052585006580 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1052585006581 Transglycosylase; Region: Transgly; pfam00912 1052585006582 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052585006583 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052585006584 Interdomain contacts; other site 1052585006585 Cytokine receptor motif; other site 1052585006586 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1052585006587 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052585006588 minor groove reading motif; other site 1052585006589 helix-hairpin-helix signature motif; other site 1052585006590 substrate binding pocket [chemical binding]; other site 1052585006591 active site 1052585006592 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1052585006593 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1052585006594 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1052585006595 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1052585006596 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1052585006597 putative dimer interface [polypeptide binding]; other site 1052585006598 putative anticodon binding site; other site 1052585006599 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1052585006600 homodimer interface [polypeptide binding]; other site 1052585006601 motif 1; other site 1052585006602 motif 2; other site 1052585006603 active site 1052585006604 motif 3; other site 1052585006605 aspartate aminotransferase; Provisional; Region: PRK05764 1052585006606 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585006607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585006608 homodimer interface [polypeptide binding]; other site 1052585006609 catalytic residue [active] 1052585006610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1052585006611 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052585006612 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1052585006613 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1052585006614 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1052585006615 active site 1052585006616 catalytic site [active] 1052585006617 substrate binding site [chemical binding]; other site 1052585006618 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1052585006619 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1052585006620 tetramerization interface [polypeptide binding]; other site 1052585006621 active site 1052585006622 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1052585006623 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1052585006624 active site 1052585006625 ATP-binding site [chemical binding]; other site 1052585006626 pantoate-binding site; other site 1052585006627 HXXH motif; other site 1052585006628 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1052585006629 oligomerization interface [polypeptide binding]; other site 1052585006630 active site 1052585006631 metal binding site [ion binding]; metal-binding site 1052585006632 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1052585006633 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1052585006634 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1052585006635 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1052585006636 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1052585006637 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1052585006638 active site 1052585006639 NTP binding site [chemical binding]; other site 1052585006640 metal binding triad [ion binding]; metal-binding site 1052585006641 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1052585006642 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1052585006643 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1052585006644 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1052585006645 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1052585006646 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1052585006647 active site 1052585006648 dimer interfaces [polypeptide binding]; other site 1052585006649 catalytic residues [active] 1052585006650 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1052585006651 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1052585006652 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1052585006653 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1052585006654 homodimer interface [polypeptide binding]; other site 1052585006655 metal binding site [ion binding]; metal-binding site 1052585006656 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585006657 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585006658 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585006659 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052585006660 Predicted membrane protein [Function unknown]; Region: COG4347 1052585006661 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1052585006662 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1052585006663 intrachain domain interface; other site 1052585006664 Qi binding site; other site 1052585006665 Qo binding site; other site 1052585006666 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1052585006667 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1052585006668 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1052585006669 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1052585006670 interchain domain interface [polypeptide binding]; other site 1052585006671 intrachain domain interface; other site 1052585006672 heme bH binding site [chemical binding]; other site 1052585006673 Qi binding site; other site 1052585006674 heme bL binding site [chemical binding]; other site 1052585006675 Qo binding site; other site 1052585006676 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1052585006677 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1052585006678 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1052585006679 iron-sulfur cluster [ion binding]; other site 1052585006680 [2Fe-2S] cluster binding site [ion binding]; other site 1052585006681 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1052585006682 hypothetical protein; Provisional; Region: PRK03636 1052585006683 UPF0302 domain; Region: UPF0302; pfam08864 1052585006684 IDEAL domain; Region: IDEAL; pfam08858 1052585006685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585006686 TPR motif; other site 1052585006687 binding surface 1052585006688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585006689 binding surface 1052585006690 TPR motif; other site 1052585006691 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585006692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585006693 TPR motif; other site 1052585006694 binding surface 1052585006695 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1052585006696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585006697 binding surface 1052585006698 TPR motif; other site 1052585006699 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1052585006700 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1052585006701 hinge; other site 1052585006702 active site 1052585006703 prephenate dehydrogenase; Validated; Region: PRK06545 1052585006704 prephenate dehydrogenase; Validated; Region: PRK08507 1052585006705 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1052585006706 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1052585006707 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585006708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585006709 homodimer interface [polypeptide binding]; other site 1052585006710 catalytic residue [active] 1052585006711 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1052585006712 substrate binding site [chemical binding]; other site 1052585006713 active site 1052585006714 catalytic residues [active] 1052585006715 heterodimer interface [polypeptide binding]; other site 1052585006716 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1052585006717 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1052585006718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585006719 catalytic residue [active] 1052585006720 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1052585006721 active site 1052585006722 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1052585006723 active site 1052585006724 ribulose/triose binding site [chemical binding]; other site 1052585006725 phosphate binding site [ion binding]; other site 1052585006726 substrate (anthranilate) binding pocket [chemical binding]; other site 1052585006727 product (indole) binding pocket [chemical binding]; other site 1052585006728 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1052585006729 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1052585006730 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1052585006731 anthranilate synthase component I; Provisional; Region: PRK13569 1052585006732 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1052585006733 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1052585006734 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1052585006735 homotrimer interaction site [polypeptide binding]; other site 1052585006736 active site 1052585006737 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1052585006738 active site 1052585006739 dimer interface [polypeptide binding]; other site 1052585006740 metal binding site [ion binding]; metal-binding site 1052585006741 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1052585006742 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1052585006743 Tetramer interface [polypeptide binding]; other site 1052585006744 active site 1052585006745 FMN-binding site [chemical binding]; other site 1052585006746 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1052585006747 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1052585006748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585006749 S-adenosylmethionine binding site [chemical binding]; other site 1052585006750 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1052585006751 active site 1052585006752 multimer interface [polypeptide binding]; other site 1052585006753 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1052585006754 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1052585006755 substrate binding pocket [chemical binding]; other site 1052585006756 chain length determination region; other site 1052585006757 substrate-Mg2+ binding site; other site 1052585006758 catalytic residues [active] 1052585006759 aspartate-rich region 1; other site 1052585006760 active site lid residues [active] 1052585006761 aspartate-rich region 2; other site 1052585006762 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1052585006763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585006764 S-adenosylmethionine binding site [chemical binding]; other site 1052585006765 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1052585006766 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1052585006767 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1052585006768 homodecamer interface [polypeptide binding]; other site 1052585006769 GTP cyclohydrolase I; Provisional; Region: PLN03044 1052585006770 active site 1052585006771 putative catalytic site residues [active] 1052585006772 zinc binding site [ion binding]; other site 1052585006773 GTP-CH-I/GFRP interaction surface; other site 1052585006774 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1052585006775 IHF dimer interface [polypeptide binding]; other site 1052585006776 IHF - DNA interface [nucleotide binding]; other site 1052585006777 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1052585006778 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1052585006779 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1052585006780 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1052585006781 GTP-binding protein Der; Reviewed; Region: PRK00093 1052585006782 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1052585006783 G1 box; other site 1052585006784 GTP/Mg2+ binding site [chemical binding]; other site 1052585006785 Switch I region; other site 1052585006786 G2 box; other site 1052585006787 Switch II region; other site 1052585006788 G3 box; other site 1052585006789 G4 box; other site 1052585006790 G5 box; other site 1052585006791 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1052585006792 G1 box; other site 1052585006793 GTP/Mg2+ binding site [chemical binding]; other site 1052585006794 Switch I region; other site 1052585006795 G2 box; other site 1052585006796 G3 box; other site 1052585006797 Switch II region; other site 1052585006798 G4 box; other site 1052585006799 G5 box; other site 1052585006800 YIEGIA protein; Region: YIEGIA; pfam14045 1052585006801 YpzI-like protein; Region: YpzI; pfam14140 1052585006802 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1052585006803 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1052585006804 homotetramer interface [polypeptide binding]; other site 1052585006805 FMN binding site [chemical binding]; other site 1052585006806 homodimer contacts [polypeptide binding]; other site 1052585006807 putative active site [active] 1052585006808 putative substrate binding site [chemical binding]; other site 1052585006809 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1052585006810 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1052585006811 RNA binding site [nucleotide binding]; other site 1052585006812 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1052585006813 RNA binding site [nucleotide binding]; other site 1052585006814 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052585006815 RNA binding site [nucleotide binding]; other site 1052585006816 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1052585006817 RNA binding site [nucleotide binding]; other site 1052585006818 cytidylate kinase; Provisional; Region: cmk; PRK00023 1052585006819 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1052585006820 CMP-binding site; other site 1052585006821 The sites determining sugar specificity; other site 1052585006822 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1052585006823 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1052585006824 PilZ domain; Region: PilZ; pfam07238 1052585006825 germination protein YpeB; Region: spore_YpeB; TIGR02889 1052585006826 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052585006827 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052585006828 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1052585006829 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1052585006830 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1052585006831 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585006832 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1052585006833 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1052585006834 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1052585006835 NAD(P) binding site [chemical binding]; other site 1052585006836 adaptor protein; Provisional; Region: PRK02899 1052585006837 phosphodiesterase YaeI; Provisional; Region: PRK11340 1052585006838 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1052585006839 putative active site [active] 1052585006840 putative metal binding site [ion binding]; other site 1052585006841 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1052585006842 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585006843 CAAX protease self-immunity; Region: Abi; pfam02517 1052585006844 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1052585006845 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585006846 ATP binding site [chemical binding]; other site 1052585006847 putative Mg++ binding site [ion binding]; other site 1052585006848 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585006849 nucleotide binding region [chemical binding]; other site 1052585006850 ATP-binding site [chemical binding]; other site 1052585006851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1052585006852 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1052585006853 Predicted membrane protein [Function unknown]; Region: COG3601 1052585006854 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1052585006855 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1052585006856 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1052585006857 ligand binding site [chemical binding]; other site 1052585006858 NAD binding site [chemical binding]; other site 1052585006859 dimerization interface [polypeptide binding]; other site 1052585006860 catalytic site [active] 1052585006861 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1052585006862 putative L-serine binding site [chemical binding]; other site 1052585006863 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1052585006864 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1052585006865 active site 1052585006866 catalytic residue [active] 1052585006867 dimer interface [polypeptide binding]; other site 1052585006868 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1052585006869 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585006870 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585006871 DNA binding residues [nucleotide binding] 1052585006872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1052585006873 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585006874 dimerization interface [polypeptide binding]; other site 1052585006875 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585006876 putative active site [active] 1052585006877 heme pocket [chemical binding]; other site 1052585006878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585006879 dimer interface [polypeptide binding]; other site 1052585006880 phosphorylation site [posttranslational modification] 1052585006881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585006882 ATP binding site [chemical binding]; other site 1052585006883 Mg2+ binding site [ion binding]; other site 1052585006884 G-X-G motif; other site 1052585006885 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585006886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585006887 active site 1052585006888 phosphorylation site [posttranslational modification] 1052585006889 intermolecular recognition site; other site 1052585006890 dimerization interface [polypeptide binding]; other site 1052585006891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585006892 DNA binding site [nucleotide binding] 1052585006893 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1052585006894 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1052585006895 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1052585006896 ResB-like family; Region: ResB; pfam05140 1052585006897 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052585006898 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052585006899 catalytic residues [active] 1052585006900 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1052585006901 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585006902 RNA binding surface [nucleotide binding]; other site 1052585006903 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1052585006904 active site 1052585006905 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1052585006906 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1052585006907 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1052585006908 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1052585006909 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1052585006910 segregation and condensation protein B; Region: TIGR00281 1052585006911 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1052585006912 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1052585006913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585006914 Coenzyme A binding pocket [chemical binding]; other site 1052585006915 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1052585006916 homopentamer interface [polypeptide binding]; other site 1052585006917 active site 1052585006918 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1052585006919 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1052585006920 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1052585006921 dimerization interface [polypeptide binding]; other site 1052585006922 active site 1052585006923 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1052585006924 Lumazine binding domain; Region: Lum_binding; pfam00677 1052585006925 Lumazine binding domain; Region: Lum_binding; pfam00677 1052585006926 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1052585006927 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1052585006928 catalytic motif [active] 1052585006929 Zn binding site [ion binding]; other site 1052585006930 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1052585006931 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052585006932 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052585006933 Catalytic site [active] 1052585006934 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 1052585006935 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052585006936 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1052585006937 active site 1052585006938 Predicted secreted protein [Function unknown]; Region: COG4086 1052585006939 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1052585006940 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1052585006941 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1052585006942 active site 1052585006943 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052585006944 substrate binding site [chemical binding]; other site 1052585006945 catalytic residues [active] 1052585006946 dimer interface [polypeptide binding]; other site 1052585006947 stage V sporulation protein AD; Validated; Region: PRK08304 1052585006948 stage V sporulation protein AD; Provisional; Region: PRK12404 1052585006949 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1052585006950 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1052585006951 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1052585006952 sporulation sigma factor SigF; Validated; Region: PRK05572 1052585006953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585006954 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052585006955 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585006956 DNA binding residues [nucleotide binding] 1052585006957 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1052585006958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585006959 ATP binding site [chemical binding]; other site 1052585006960 Mg2+ binding site [ion binding]; other site 1052585006961 G-X-G motif; other site 1052585006962 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1052585006963 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1052585006964 phosphopentomutase; Provisional; Region: PRK05362 1052585006965 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1052585006966 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1052585006967 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1052585006968 active site 1052585006969 Int/Topo IB signature motif; other site 1052585006970 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1052585006971 ferric uptake regulator; Provisional; Region: fur; PRK09462 1052585006972 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052585006973 metal binding site 2 [ion binding]; metal-binding site 1052585006974 putative DNA binding helix; other site 1052585006975 metal binding site 1 [ion binding]; metal-binding site 1052585006976 dimer interface [polypeptide binding]; other site 1052585006977 structural Zn2+ binding site [ion binding]; other site 1052585006978 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1052585006979 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1052585006980 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1052585006981 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052585006982 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1052585006983 NAD(P) binding pocket [chemical binding]; other site 1052585006984 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1052585006985 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1052585006986 Aspartase; Region: Aspartase; cd01357 1052585006987 active sites [active] 1052585006988 tetramer interface [polypeptide binding]; other site 1052585006989 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1052585006990 active site 1052585006991 homodimer interface [polypeptide binding]; other site 1052585006992 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052585006993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585006994 non-specific DNA binding site [nucleotide binding]; other site 1052585006995 salt bridge; other site 1052585006996 sequence-specific DNA binding site [nucleotide binding]; other site 1052585006997 TIGR00375 family protein; Region: TIGR00375 1052585006998 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1052585006999 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1052585007000 dimer interface [polypeptide binding]; other site 1052585007001 ADP-ribose binding site [chemical binding]; other site 1052585007002 active site 1052585007003 nudix motif; other site 1052585007004 metal binding site [ion binding]; metal-binding site 1052585007005 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1052585007006 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585007007 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052585007008 active site 1052585007009 catalytic tetrad [active] 1052585007010 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 1052585007011 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1052585007012 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052585007013 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 1052585007014 cell division protein FtsW; Region: ftsW; TIGR02614 1052585007015 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1052585007016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585007017 sequence-specific DNA binding site [nucleotide binding]; other site 1052585007018 salt bridge; other site 1052585007019 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1052585007020 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1052585007021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1052585007022 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052585007023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585007024 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052585007025 Coenzyme A binding pocket [chemical binding]; other site 1052585007026 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1052585007027 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1052585007028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1052585007029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585007030 Coenzyme A binding pocket [chemical binding]; other site 1052585007031 YolD-like protein; Region: YolD; pfam08863 1052585007032 DNA polymerase IV; Reviewed; Region: PRK03103 1052585007033 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1052585007034 active site 1052585007035 DNA binding site [nucleotide binding] 1052585007036 YqzH-like protein; Region: YqzH; pfam14164 1052585007037 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585007038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585007039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585007040 putative substrate translocation pore; other site 1052585007041 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1052585007042 putative dimer interface [polypeptide binding]; other site 1052585007043 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585007044 ligand binding site [chemical binding]; other site 1052585007045 Zn binding site [ion binding]; other site 1052585007046 pantothenate kinase; Provisional; Region: PRK05439 1052585007047 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1052585007048 ATP-binding site [chemical binding]; other site 1052585007049 CoA-binding site [chemical binding]; other site 1052585007050 Mg2+-binding site [ion binding]; other site 1052585007051 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1052585007052 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1052585007053 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585007054 catalytic residue [active] 1052585007055 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1052585007056 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 1052585007057 NADP binding site [chemical binding]; other site 1052585007058 homodimer interface [polypeptide binding]; other site 1052585007059 substrate binding site [chemical binding]; other site 1052585007060 active site 1052585007061 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1052585007062 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1052585007063 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1052585007064 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1052585007065 putative metal binding site [ion binding]; other site 1052585007066 putative dimer interface [polypeptide binding]; other site 1052585007067 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1052585007068 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1052585007069 active site 1052585007070 FMN binding site [chemical binding]; other site 1052585007071 substrate binding site [chemical binding]; other site 1052585007072 homotetramer interface [polypeptide binding]; other site 1052585007073 catalytic residue [active] 1052585007074 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585007075 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1052585007076 putative hydrolase; Provisional; Region: PRK02113 1052585007077 ribonuclease Z; Region: RNase_Z; TIGR02651 1052585007078 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1052585007079 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1052585007080 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1052585007081 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1052585007082 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1052585007083 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1052585007084 DNA polymerase IV; Validated; Region: PRK01810 1052585007085 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1052585007086 active site 1052585007087 DNA binding site [nucleotide binding] 1052585007088 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1052585007089 OxaA-like protein precursor; Validated; Region: PRK01622 1052585007090 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1052585007091 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 1052585007092 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1052585007093 peptidase T-like protein; Region: PepT-like; TIGR01883 1052585007094 metal binding site [ion binding]; metal-binding site 1052585007095 putative dimer interface [polypeptide binding]; other site 1052585007096 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1052585007097 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1052585007098 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1052585007099 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585007100 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1052585007101 dimer interface [polypeptide binding]; other site 1052585007102 substrate binding site [chemical binding]; other site 1052585007103 metal binding site [ion binding]; metal-binding site 1052585007104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1052585007105 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1052585007106 Predicted membrane protein [Function unknown]; Region: COG4129 1052585007107 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1052585007108 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1052585007109 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052585007110 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052585007111 Walker A/P-loop; other site 1052585007112 ATP binding site [chemical binding]; other site 1052585007113 Q-loop/lid; other site 1052585007114 ABC transporter signature motif; other site 1052585007115 Walker B; other site 1052585007116 D-loop; other site 1052585007117 H-loop/switch region; other site 1052585007118 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052585007119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585007120 dimer interface [polypeptide binding]; other site 1052585007121 conserved gate region; other site 1052585007122 putative PBP binding loops; other site 1052585007123 ABC-ATPase subunit interface; other site 1052585007124 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052585007125 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052585007126 substrate binding pocket [chemical binding]; other site 1052585007127 membrane-bound complex binding site; other site 1052585007128 hinge residues; other site 1052585007129 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1052585007130 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1052585007131 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1052585007132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585007133 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585007134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585007135 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052585007136 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052585007137 DNA binding residues [nucleotide binding] 1052585007138 drug binding residues [chemical binding]; other site 1052585007139 dimer interface [polypeptide binding]; other site 1052585007140 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1052585007141 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1052585007142 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052585007143 E3 interaction surface; other site 1052585007144 lipoyl attachment site [posttranslational modification]; other site 1052585007145 e3 binding domain; Region: E3_binding; pfam02817 1052585007146 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1052585007147 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052585007148 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052585007149 alpha subunit interface [polypeptide binding]; other site 1052585007150 TPP binding site [chemical binding]; other site 1052585007151 heterodimer interface [polypeptide binding]; other site 1052585007152 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052585007153 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1052585007154 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052585007155 tetramer interface [polypeptide binding]; other site 1052585007156 TPP-binding site [chemical binding]; other site 1052585007157 heterodimer interface [polypeptide binding]; other site 1052585007158 phosphorylation loop region [posttranslational modification] 1052585007159 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1052585007160 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1052585007161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585007162 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052585007163 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052585007164 nucleotide binding site [chemical binding]; other site 1052585007165 Acetokinase family; Region: Acetate_kinase; cl17229 1052585007166 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1052585007167 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1052585007168 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1052585007169 NAD binding site [chemical binding]; other site 1052585007170 Phe binding site; other site 1052585007171 phosphate butyryltransferase; Validated; Region: PRK07742 1052585007172 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1052585007173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585007174 putative active site [active] 1052585007175 heme pocket [chemical binding]; other site 1052585007176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585007177 putative active site [active] 1052585007178 heme pocket [chemical binding]; other site 1052585007179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585007180 Walker A motif; other site 1052585007181 ATP binding site [chemical binding]; other site 1052585007182 Walker B motif; other site 1052585007183 arginine finger; other site 1052585007184 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1052585007185 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1052585007186 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1052585007187 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1052585007188 tetramer interface [polypeptide binding]; other site 1052585007189 active site 1052585007190 Mg2+/Mn2+ binding site [ion binding]; other site 1052585007191 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1052585007192 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1052585007193 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1052585007194 dimer interface [polypeptide binding]; other site 1052585007195 Citrate synthase; Region: Citrate_synt; pfam00285 1052585007196 active site 1052585007197 coenzyme A binding site [chemical binding]; other site 1052585007198 citrylCoA binding site [chemical binding]; other site 1052585007199 oxalacetate/citrate binding site [chemical binding]; other site 1052585007200 catalytic triad [active] 1052585007201 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052585007202 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1052585007203 FAD binding site [chemical binding]; other site 1052585007204 homotetramer interface [polypeptide binding]; other site 1052585007205 substrate binding pocket [chemical binding]; other site 1052585007206 catalytic base [active] 1052585007207 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1052585007208 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1052585007209 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1052585007210 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1052585007211 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1052585007212 dimer interface [polypeptide binding]; other site 1052585007213 active site 1052585007214 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1052585007215 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1052585007216 active site 1052585007217 catalytic site [active] 1052585007218 metal binding site [ion binding]; metal-binding site 1052585007219 dimer interface [polypeptide binding]; other site 1052585007220 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1052585007221 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052585007222 active site 1052585007223 metal binding site [ion binding]; metal-binding site 1052585007224 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1052585007225 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1052585007226 putative active site [active] 1052585007227 putative FMN binding site [chemical binding]; other site 1052585007228 putative substrate binding site [chemical binding]; other site 1052585007229 putative catalytic residue [active] 1052585007230 Protein of unknown function DUF45; Region: DUF45; pfam01863 1052585007231 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1052585007232 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1052585007233 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585007234 ATP binding site [chemical binding]; other site 1052585007235 putative Mg++ binding site [ion binding]; other site 1052585007236 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1052585007237 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1052585007238 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1052585007239 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1052585007240 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1052585007241 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1052585007242 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052585007243 active site 1052585007244 DNA binding site [nucleotide binding] 1052585007245 Int/Topo IB signature motif; other site 1052585007246 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1052585007247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585007248 active site 1052585007249 phosphorylation site [posttranslational modification] 1052585007250 intermolecular recognition site; other site 1052585007251 dimerization interface [polypeptide binding]; other site 1052585007252 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1052585007253 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1052585007254 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1052585007255 protein binding site [polypeptide binding]; other site 1052585007256 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1052585007257 DNA repair protein RecN; Region: recN; TIGR00634 1052585007258 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1052585007259 Walker A/P-loop; other site 1052585007260 ATP binding site [chemical binding]; other site 1052585007261 Q-loop/lid; other site 1052585007262 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1052585007263 ABC transporter signature motif; other site 1052585007264 Walker B; other site 1052585007265 D-loop; other site 1052585007266 H-loop/switch region; other site 1052585007267 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1052585007268 arginine repressor; Provisional; Region: PRK04280 1052585007269 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1052585007270 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1052585007271 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585007272 RNA binding surface [nucleotide binding]; other site 1052585007273 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1052585007274 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1052585007275 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1052585007276 TPP-binding site; other site 1052585007277 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1052585007278 PYR/PP interface [polypeptide binding]; other site 1052585007279 dimer interface [polypeptide binding]; other site 1052585007280 TPP binding site [chemical binding]; other site 1052585007281 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052585007282 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1052585007283 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1052585007284 substrate binding pocket [chemical binding]; other site 1052585007285 chain length determination region; other site 1052585007286 substrate-Mg2+ binding site; other site 1052585007287 catalytic residues [active] 1052585007288 aspartate-rich region 1; other site 1052585007289 active site lid residues [active] 1052585007290 aspartate-rich region 2; other site 1052585007291 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1052585007292 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1052585007293 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1052585007294 generic binding surface II; other site 1052585007295 generic binding surface I; other site 1052585007296 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1052585007297 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1052585007298 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1052585007299 homodimer interface [polypeptide binding]; other site 1052585007300 NADP binding site [chemical binding]; other site 1052585007301 substrate binding site [chemical binding]; other site 1052585007302 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1052585007303 putative RNA binding site [nucleotide binding]; other site 1052585007304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1052585007305 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1052585007306 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585007307 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1052585007308 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1052585007309 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1052585007310 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052585007311 carboxyltransferase (CT) interaction site; other site 1052585007312 biotinylation site [posttranslational modification]; other site 1052585007313 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1052585007314 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1052585007315 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1052585007316 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1052585007317 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1052585007318 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1052585007319 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1052585007320 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1052585007321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585007322 Walker A motif; other site 1052585007323 ATP binding site [chemical binding]; other site 1052585007324 Walker B motif; other site 1052585007325 arginine finger; other site 1052585007326 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1052585007327 elongation factor P; Validated; Region: PRK00529 1052585007328 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1052585007329 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1052585007330 RNA binding site [nucleotide binding]; other site 1052585007331 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1052585007332 RNA binding site [nucleotide binding]; other site 1052585007333 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1052585007334 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1052585007335 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1052585007336 active site 1052585007337 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1052585007338 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1052585007339 trimer interface [polypeptide binding]; other site 1052585007340 active site 1052585007341 dimer interface [polypeptide binding]; other site 1052585007342 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1052585007343 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1052585007344 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1052585007345 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1052585007346 active site 1052585007347 nucleophile elbow; other site 1052585007348 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1052585007349 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1052585007350 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1052585007351 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1052585007352 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052585007353 active site residue [active] 1052585007354 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1052585007355 tetramer interface [polypeptide binding]; other site 1052585007356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585007357 catalytic residue [active] 1052585007358 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1052585007359 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1052585007360 tetramer interface [polypeptide binding]; other site 1052585007361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585007362 catalytic residue [active] 1052585007363 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1052585007364 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1052585007365 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1052585007366 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1052585007367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585007368 ATP binding site [chemical binding]; other site 1052585007369 putative Mg++ binding site [ion binding]; other site 1052585007370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585007371 nucleotide binding region [chemical binding]; other site 1052585007372 ATP-binding site [chemical binding]; other site 1052585007373 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1052585007374 Anti-repressor SinI; Region: SinI; pfam08671 1052585007375 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052585007376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585007377 non-specific DNA binding site [nucleotide binding]; other site 1052585007378 salt bridge; other site 1052585007379 sequence-specific DNA binding site [nucleotide binding]; other site 1052585007380 Anti-repressor SinI; Region: SinI; pfam08671 1052585007381 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1052585007382 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1052585007383 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1052585007384 Catalytic site [active] 1052585007385 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1052585007386 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1052585007387 YqzE-like protein; Region: YqzE; pfam14038 1052585007388 ComG operon protein 7; Region: ComGG; pfam14173 1052585007389 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1052585007390 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1052585007391 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1052585007392 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1052585007393 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1052585007394 Type II/IV secretion system protein; Region: T2SE; pfam00437 1052585007395 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1052585007396 Walker A motif; other site 1052585007397 ATP binding site [chemical binding]; other site 1052585007398 Walker B motif; other site 1052585007399 FOG: CBS domain [General function prediction only]; Region: COG0517 1052585007400 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1052585007401 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1052585007402 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1052585007403 Cl binding site [ion binding]; other site 1052585007404 oligomer interface [polypeptide binding]; other site 1052585007405 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052585007406 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052585007407 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052585007408 Transporter associated domain; Region: CorC_HlyC; smart01091 1052585007409 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1052585007410 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585007411 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1052585007412 ArsC family; Region: ArsC; pfam03960 1052585007413 putative catalytic residues [active] 1052585007414 thiol/disulfide switch; other site 1052585007415 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1052585007416 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052585007417 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1052585007418 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1052585007419 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1052585007420 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1052585007421 putative active site [active] 1052585007422 Zn binding site [ion binding]; other site 1052585007423 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052585007424 Sulfatase; Region: Sulfatase; pfam00884 1052585007425 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1052585007426 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052585007427 nucleotide binding site [chemical binding]; other site 1052585007428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1052585007429 Rhomboid family; Region: Rhomboid; pfam01694 1052585007430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585007431 binding surface 1052585007432 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585007433 TPR motif; other site 1052585007434 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585007435 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1052585007436 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1052585007437 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585007438 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052585007439 YceG-like family; Region: YceG; pfam02618 1052585007440 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1052585007441 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1052585007442 Walker A/P-loop; other site 1052585007443 ATP binding site [chemical binding]; other site 1052585007444 Q-loop/lid; other site 1052585007445 ABC transporter signature motif; other site 1052585007446 Walker B; other site 1052585007447 D-loop; other site 1052585007448 H-loop/switch region; other site 1052585007449 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1052585007450 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1052585007451 Walker A/P-loop; other site 1052585007452 ATP binding site [chemical binding]; other site 1052585007453 Q-loop/lid; other site 1052585007454 ABC transporter signature motif; other site 1052585007455 Walker B; other site 1052585007456 D-loop; other site 1052585007457 H-loop/switch region; other site 1052585007458 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1052585007459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585007460 dimer interface [polypeptide binding]; other site 1052585007461 conserved gate region; other site 1052585007462 ABC-ATPase subunit interface; other site 1052585007463 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1052585007464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585007465 dimer interface [polypeptide binding]; other site 1052585007466 conserved gate region; other site 1052585007467 putative PBP binding loops; other site 1052585007468 ABC-ATPase subunit interface; other site 1052585007469 PBP superfamily domain; Region: PBP_like_2; cl17296 1052585007470 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1052585007471 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052585007472 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585007473 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052585007474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585007475 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585007476 putative substrate translocation pore; other site 1052585007477 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1052585007478 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1052585007479 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1052585007480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1052585007481 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1052585007482 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585007483 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1052585007484 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1052585007485 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1052585007486 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1052585007487 ferric uptake regulator; Provisional; Region: fur; PRK09462 1052585007488 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052585007489 metal binding site 2 [ion binding]; metal-binding site 1052585007490 putative DNA binding helix; other site 1052585007491 metal binding site 1 [ion binding]; metal-binding site 1052585007492 dimer interface [polypeptide binding]; other site 1052585007493 structural Zn2+ binding site [ion binding]; other site 1052585007494 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585007495 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585007496 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585007497 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052585007498 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1052585007499 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1052585007500 endonuclease IV; Provisional; Region: PRK01060 1052585007501 AP (apurinic/apyrimidinic) site pocket; other site 1052585007502 DNA interaction; other site 1052585007503 Metal-binding active site; metal-binding site 1052585007504 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052585007505 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1052585007506 ATP binding site [chemical binding]; other site 1052585007507 Mg++ binding site [ion binding]; other site 1052585007508 motif III; other site 1052585007509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585007510 nucleotide binding region [chemical binding]; other site 1052585007511 ATP-binding site [chemical binding]; other site 1052585007512 YqfQ-like protein; Region: YqfQ; pfam14181 1052585007513 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1052585007514 LytB protein; Region: LYTB; pfam02401 1052585007515 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1052585007516 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 1052585007517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1052585007518 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1052585007519 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1052585007520 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1052585007521 Family of unknown function (DUF633); Region: DUF633; pfam04816 1052585007522 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1052585007523 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1052585007524 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1052585007525 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1052585007526 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1052585007527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585007528 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052585007529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585007530 DNA binding residues [nucleotide binding] 1052585007531 DNA primase; Validated; Region: dnaG; PRK05667 1052585007532 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1052585007533 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1052585007534 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1052585007535 active site 1052585007536 metal binding site [ion binding]; metal-binding site 1052585007537 interdomain interaction site; other site 1052585007538 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1052585007539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1052585007540 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1052585007541 HTH domain; Region: HTH_11; pfam08279 1052585007542 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1052585007543 FOG: CBS domain [General function prediction only]; Region: COG0517 1052585007544 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1052585007545 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1052585007546 dimer interface [polypeptide binding]; other site 1052585007547 motif 1; other site 1052585007548 active site 1052585007549 motif 2; other site 1052585007550 motif 3; other site 1052585007551 Recombination protein O N terminal; Region: RecO_N; pfam11967 1052585007552 DNA repair protein RecO; Region: reco; TIGR00613 1052585007553 Recombination protein O C terminal; Region: RecO_C; pfam02565 1052585007554 YqzL-like protein; Region: YqzL; pfam14006 1052585007555 GTPase Era; Reviewed; Region: era; PRK00089 1052585007556 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1052585007557 G1 box; other site 1052585007558 GTP/Mg2+ binding site [chemical binding]; other site 1052585007559 Switch I region; other site 1052585007560 G2 box; other site 1052585007561 Switch II region; other site 1052585007562 G3 box; other site 1052585007563 G4 box; other site 1052585007564 G5 box; other site 1052585007565 KH domain; Region: KH_2; pfam07650 1052585007566 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1052585007567 active site 1052585007568 catalytic motif [active] 1052585007569 Zn binding site [ion binding]; other site 1052585007570 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1052585007571 metal-binding heat shock protein; Provisional; Region: PRK00016 1052585007572 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1052585007573 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1052585007574 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052585007575 Zn2+ binding site [ion binding]; other site 1052585007576 Mg2+ binding site [ion binding]; other site 1052585007577 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1052585007578 PhoH-like protein; Region: PhoH; pfam02562 1052585007579 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1052585007580 hypothetical protein; Provisional; Region: PRK13665 1052585007581 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1052585007582 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1052585007583 dimer interface [polypeptide binding]; other site 1052585007584 active site residues [active] 1052585007585 Yqey-like protein; Region: YqeY; pfam09424 1052585007586 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1052585007587 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1052585007588 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052585007589 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052585007590 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1052585007591 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1052585007592 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585007593 FeS/SAM binding site; other site 1052585007594 TRAM domain; Region: TRAM; cl01282 1052585007595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1052585007596 RNA methyltransferase, RsmE family; Region: TIGR00046 1052585007597 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1052585007598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585007599 S-adenosylmethionine binding site [chemical binding]; other site 1052585007600 chaperone protein DnaJ; Provisional; Region: PRK14280 1052585007601 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1052585007602 HSP70 interaction site [polypeptide binding]; other site 1052585007603 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1052585007604 substrate binding site [polypeptide binding]; other site 1052585007605 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1052585007606 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1052585007607 dimer interface [polypeptide binding]; other site 1052585007608 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1052585007609 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1052585007610 nucleotide binding site [chemical binding]; other site 1052585007611 NEF interaction site [polypeptide binding]; other site 1052585007612 SBD interface [polypeptide binding]; other site 1052585007613 heat shock protein GrpE; Provisional; Region: PRK14140 1052585007614 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1052585007615 dimer interface [polypeptide binding]; other site 1052585007616 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1052585007617 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1052585007618 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1052585007619 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1052585007620 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585007621 FeS/SAM binding site; other site 1052585007622 HemN C-terminal domain; Region: HemN_C; pfam06969 1052585007623 GTP-binding protein LepA; Provisional; Region: PRK05433 1052585007624 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1052585007625 G1 box; other site 1052585007626 putative GEF interaction site [polypeptide binding]; other site 1052585007627 GTP/Mg2+ binding site [chemical binding]; other site 1052585007628 Switch I region; other site 1052585007629 G2 box; other site 1052585007630 G3 box; other site 1052585007631 Switch II region; other site 1052585007632 G4 box; other site 1052585007633 G5 box; other site 1052585007634 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1052585007635 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1052585007636 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1052585007637 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1052585007638 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1052585007639 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1052585007640 germination protease; Provisional; Region: PRK02858 1052585007641 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1052585007642 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1052585007643 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1052585007644 YqzM-like protein; Region: YqzM; pfam14141 1052585007645 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1052585007646 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1052585007647 Competence protein; Region: Competence; pfam03772 1052585007648 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052585007649 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1052585007650 catalytic motif [active] 1052585007651 Zn binding site [ion binding]; other site 1052585007652 SLBB domain; Region: SLBB; pfam10531 1052585007653 comEA protein; Region: comE; TIGR01259 1052585007654 Helix-hairpin-helix motif; Region: HHH; pfam00633 1052585007655 late competence protein ComER; Validated; Region: PRK07680 1052585007656 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1052585007657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585007658 S-adenosylmethionine binding site [chemical binding]; other site 1052585007659 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1052585007660 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052585007661 Zn2+ binding site [ion binding]; other site 1052585007662 Mg2+ binding site [ion binding]; other site 1052585007663 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1052585007664 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1052585007665 active site 1052585007666 (T/H)XGH motif; other site 1052585007667 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 1052585007668 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1052585007669 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1052585007670 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1052585007671 shikimate binding site; other site 1052585007672 NAD(P) binding site [chemical binding]; other site 1052585007673 GTPase YqeH; Provisional; Region: PRK13796 1052585007674 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1052585007675 GTP/Mg2+ binding site [chemical binding]; other site 1052585007676 G4 box; other site 1052585007677 G5 box; other site 1052585007678 G1 box; other site 1052585007679 Switch I region; other site 1052585007680 G2 box; other site 1052585007681 G3 box; other site 1052585007682 Switch II region; other site 1052585007683 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1052585007684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585007685 active site 1052585007686 motif I; other site 1052585007687 motif II; other site 1052585007688 Sporulation inhibitor A; Region: Sda; pfam08970 1052585007689 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 1052585007690 active site 1052585007691 catalytic triad [active] 1052585007692 oxyanion hole [active] 1052585007693 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1052585007694 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052585007695 amidase catalytic site [active] 1052585007696 Zn binding residues [ion binding]; other site 1052585007697 substrate binding site [chemical binding]; other site 1052585007698 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052585007699 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052585007700 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1052585007701 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052585007702 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1052585007703 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1052585007704 arginine decarboxylase; Provisional; Region: PRK15029 1052585007705 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1052585007706 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1052585007707 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585007708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585007709 DNA binding residues [nucleotide binding] 1052585007710 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1052585007711 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1052585007712 DHHA1 domain; Region: DHHA1; pfam02272 1052585007713 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1052585007714 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1052585007715 dimer interface [polypeptide binding]; other site 1052585007716 active site 1052585007717 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052585007718 substrate binding site [chemical binding]; other site 1052585007719 catalytic residue [active] 1052585007720 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1052585007721 homotrimer interaction site [polypeptide binding]; other site 1052585007722 putative active site [active] 1052585007723 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1052585007724 active site 1052585007725 homotetramer interface [polypeptide binding]; other site 1052585007726 homodimer interface [polypeptide binding]; other site 1052585007727 threonine synthase; Validated; Region: PRK06260 1052585007728 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1052585007729 homodimer interface [polypeptide binding]; other site 1052585007730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585007731 catalytic residue [active] 1052585007732 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1052585007733 homotrimer interaction site [polypeptide binding]; other site 1052585007734 putative active site [active] 1052585007735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1052585007736 YheO-like PAS domain; Region: PAS_6; pfam08348 1052585007737 HTH domain; Region: HTH_22; pfam13309 1052585007738 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585007739 binding surface 1052585007740 TPR motif; other site 1052585007741 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585007742 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585007743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585007744 TPR motif; other site 1052585007745 binding surface 1052585007746 TPR repeat; Region: TPR_11; pfam13414 1052585007747 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1052585007748 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1052585007749 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1052585007750 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1052585007751 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1052585007752 Predicted transcriptional regulators [Transcription]; Region: COG1695 1052585007753 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1052585007754 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1052585007755 CPxP motif; other site 1052585007756 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1052585007757 active site residue [active] 1052585007758 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052585007759 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 1052585007760 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1052585007761 CPxP motif; other site 1052585007762 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052585007763 active site residue [active] 1052585007764 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052585007765 active site residue [active] 1052585007766 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1052585007767 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585007768 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052585007769 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052585007770 active site residue [active] 1052585007771 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1052585007772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052585007773 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585007774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585007775 active site 1052585007776 phosphorylation site [posttranslational modification] 1052585007777 intermolecular recognition site; other site 1052585007778 dimerization interface [polypeptide binding]; other site 1052585007779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585007780 DNA binding residues [nucleotide binding] 1052585007781 dimerization interface [polypeptide binding]; other site 1052585007782 PAS domain S-box; Region: sensory_box; TIGR00229 1052585007783 PAS domain; Region: PAS_8; pfam13188 1052585007784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1052585007785 Histidine kinase; Region: HisKA_3; pfam07730 1052585007786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585007787 ATP binding site [chemical binding]; other site 1052585007788 Mg2+ binding site [ion binding]; other site 1052585007789 G-X-G motif; other site 1052585007790 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1052585007791 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1052585007792 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1052585007793 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1052585007794 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052585007795 CAT RNA binding domain; Region: CAT_RBD; smart01061 1052585007796 PRD domain; Region: PRD; pfam00874 1052585007797 PRD domain; Region: PRD; pfam00874 1052585007798 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052585007799 beta-galactosidase; Region: BGL; TIGR03356 1052585007800 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052585007801 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585007802 active site turn [active] 1052585007803 phosphorylation site [posttranslational modification] 1052585007804 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052585007805 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052585007806 HPr interaction site; other site 1052585007807 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585007808 active site 1052585007809 phosphorylation site [posttranslational modification] 1052585007810 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052585007811 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585007812 metal-binding site [ion binding] 1052585007813 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052585007814 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585007815 metal-binding site [ion binding] 1052585007816 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052585007817 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1052585007818 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585007819 metal-binding site [ion binding] 1052585007820 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1052585007821 putative homodimer interface [polypeptide binding]; other site 1052585007822 putative homotetramer interface [polypeptide binding]; other site 1052585007823 allosteric switch controlling residues; other site 1052585007824 putative metal binding site [ion binding]; other site 1052585007825 putative homodimer-homodimer interface [polypeptide binding]; other site 1052585007826 DinB superfamily; Region: DinB_2; pfam12867 1052585007827 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1052585007828 Domain of unknown function (DUF955); Region: DUF955; cl01076 1052585007829 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1052585007830 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1052585007831 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052585007832 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585007833 putative DNA binding site [nucleotide binding]; other site 1052585007834 dimerization interface [polypeptide binding]; other site 1052585007835 putative Zn2+ binding site [ion binding]; other site 1052585007836 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1052585007837 dimer interface [polypeptide binding]; other site 1052585007838 FMN binding site [chemical binding]; other site 1052585007839 NADPH bind site [chemical binding]; other site 1052585007840 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1052585007841 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052585007842 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1052585007843 DNA binding residues [nucleotide binding] 1052585007844 dimer interface [polypeptide binding]; other site 1052585007845 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1052585007846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585007847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585007848 putative substrate translocation pore; other site 1052585007849 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052585007850 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052585007851 Coenzyme A binding pocket [chemical binding]; other site 1052585007852 Transporter associated domain; Region: CorC_HlyC; smart01091 1052585007853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052585007854 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1052585007855 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1052585007856 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052585007857 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052585007858 DNA binding residues [nucleotide binding] 1052585007859 drug binding residues [chemical binding]; other site 1052585007860 dimer interface [polypeptide binding]; other site 1052585007861 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052585007862 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1052585007863 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1052585007864 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1052585007865 active site 1052585007866 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1052585007867 YodA lipocalin-like domain; Region: YodA; pfam09223 1052585007868 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 1052585007869 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585007870 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585007871 DNA binding residues [nucleotide binding] 1052585007872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585007873 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052585007874 active site 1052585007875 catalytic tetrad [active] 1052585007876 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1052585007877 chitosan binding site [chemical binding]; other site 1052585007878 catalytic residues [active] 1052585007879 Mor transcription activator family; Region: Mor; cl02360 1052585007880 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052585007881 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052585007882 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1052585007883 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1052585007884 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1052585007885 Bacterial SH3 domain; Region: SH3_3; cl17532 1052585007886 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1052585007887 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1052585007888 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052585007889 NAD binding site [chemical binding]; other site 1052585007890 catalytic Zn binding site [ion binding]; other site 1052585007891 structural Zn binding site [ion binding]; other site 1052585007892 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1052585007893 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052585007894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585007895 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1052585007896 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052585007897 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1052585007898 DNA binding residues [nucleotide binding] 1052585007899 putative dimer interface [polypeptide binding]; other site 1052585007900 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1052585007901 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1052585007902 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1052585007903 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1052585007904 putative NAD(P) binding site [chemical binding]; other site 1052585007905 putative substrate binding site [chemical binding]; other site 1052585007906 catalytic Zn binding site [ion binding]; other site 1052585007907 structural Zn binding site [ion binding]; other site 1052585007908 dimer interface [polypeptide binding]; other site 1052585007909 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1052585007910 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1052585007911 proposed catalytic triad [active] 1052585007912 conserved cys residue [active] 1052585007913 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1052585007914 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052585007915 substrate binding [chemical binding]; other site 1052585007916 active site 1052585007917 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052585007918 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1052585007919 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 1052585007920 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1052585007921 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1052585007922 active site 1052585007923 phosphorylation site [posttranslational modification] 1052585007924 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1052585007925 active pocket/dimerization site; other site 1052585007926 active site 1052585007927 phosphorylation site [posttranslational modification] 1052585007928 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1052585007929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585007930 Walker A motif; other site 1052585007931 ATP binding site [chemical binding]; other site 1052585007932 Walker B motif; other site 1052585007933 arginine finger; other site 1052585007934 Transcriptional antiterminator [Transcription]; Region: COG3933 1052585007935 PRD domain; Region: PRD; pfam00874 1052585007936 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1052585007937 active pocket/dimerization site; other site 1052585007938 active site 1052585007939 phosphorylation site [posttranslational modification] 1052585007940 PRD domain; Region: PRD; pfam00874 1052585007941 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052585007942 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1052585007943 Predicted transcriptional regulators [Transcription]; Region: COG1378 1052585007944 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1052585007945 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1052585007946 C-terminal domain interface [polypeptide binding]; other site 1052585007947 sugar binding site [chemical binding]; other site 1052585007948 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1052585007949 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585007950 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585007951 DNA binding residues [nucleotide binding] 1052585007952 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052585007953 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1052585007954 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1052585007955 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1052585007956 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1052585007957 catalytic triad [active] 1052585007958 catalytic triad [active] 1052585007959 oxyanion hole [active] 1052585007960 YrhK-like protein; Region: YrhK; pfam14145 1052585007961 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052585007962 Cytochrome P450; Region: p450; pfam00067 1052585007963 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1052585007964 Flavodoxin; Region: Flavodoxin_1; pfam00258 1052585007965 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1052585007966 FAD binding pocket [chemical binding]; other site 1052585007967 FAD binding motif [chemical binding]; other site 1052585007968 catalytic residues [active] 1052585007969 NAD binding pocket [chemical binding]; other site 1052585007970 phosphate binding motif [ion binding]; other site 1052585007971 beta-alpha-beta structure motif; other site 1052585007972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585007973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585007974 S-adenosylmethionine binding site [chemical binding]; other site 1052585007975 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1052585007976 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1052585007977 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1052585007978 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1052585007979 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1052585007980 catalytic loop [active] 1052585007981 iron binding site [ion binding]; other site 1052585007982 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1052585007983 4Fe-4S binding domain; Region: Fer4; pfam00037 1052585007984 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1052585007985 [4Fe-4S] binding site [ion binding]; other site 1052585007986 molybdopterin cofactor binding site; other site 1052585007987 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1052585007988 molybdopterin cofactor binding site; other site 1052585007989 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1052585007990 YrhC-like protein; Region: YrhC; pfam14143 1052585007991 cystathionine beta-lyase; Provisional; Region: PRK07671 1052585007992 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052585007993 homodimer interface [polypeptide binding]; other site 1052585007994 substrate-cofactor binding pocket; other site 1052585007995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585007996 catalytic residue [active] 1052585007997 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052585007998 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052585007999 dimer interface [polypeptide binding]; other site 1052585008000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585008001 catalytic residue [active] 1052585008002 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1052585008003 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1052585008004 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1052585008005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585008006 S-adenosylmethionine binding site [chemical binding]; other site 1052585008007 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1052585008008 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1052585008009 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052585008010 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585008011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052585008012 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1052585008013 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1052585008014 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1052585008015 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1052585008016 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1052585008017 ATP-binding site [chemical binding]; other site 1052585008018 Sugar specificity; other site 1052585008019 Pyrimidine base specificity; other site 1052585008020 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1052585008021 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1052585008022 Peptidase family U32; Region: Peptidase_U32; pfam01136 1052585008023 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1052585008024 Peptidase family U32; Region: Peptidase_U32; pfam01136 1052585008025 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1052585008026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585008027 S-adenosylmethionine binding site [chemical binding]; other site 1052585008028 conserved hypothetical protein, YceG family; Region: TIGR00247 1052585008029 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1052585008030 dimerization interface [polypeptide binding]; other site 1052585008031 hypothetical protein; Provisional; Region: PRK13678 1052585008032 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1052585008033 hypothetical protein; Provisional; Region: PRK05473 1052585008034 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1052585008035 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1052585008036 motif 1; other site 1052585008037 active site 1052585008038 motif 2; other site 1052585008039 motif 3; other site 1052585008040 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1052585008041 DHHA1 domain; Region: DHHA1; pfam02272 1052585008042 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1052585008043 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052585008044 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 1052585008045 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1052585008046 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1052585008047 AAA domain; Region: AAA_30; pfam13604 1052585008048 Family description; Region: UvrD_C_2; pfam13538 1052585008049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585008050 binding surface 1052585008051 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585008052 TPR motif; other site 1052585008053 TPR repeat; Region: TPR_11; pfam13414 1052585008054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585008055 binding surface 1052585008056 TPR motif; other site 1052585008057 TPR repeat; Region: TPR_11; pfam13414 1052585008058 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1052585008059 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1052585008060 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1052585008061 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1052585008062 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585008063 catalytic residue [active] 1052585008064 Predicted transcriptional regulator [Transcription]; Region: COG1959 1052585008065 Transcriptional regulator; Region: Rrf2; pfam02082 1052585008066 recombination factor protein RarA; Reviewed; Region: PRK13342 1052585008067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585008068 Walker A motif; other site 1052585008069 ATP binding site [chemical binding]; other site 1052585008070 Walker B motif; other site 1052585008071 arginine finger; other site 1052585008072 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1052585008073 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1052585008074 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1052585008075 putative ATP binding site [chemical binding]; other site 1052585008076 putative substrate interface [chemical binding]; other site 1052585008077 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1052585008078 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1052585008079 dimer interface [polypeptide binding]; other site 1052585008080 anticodon binding site; other site 1052585008081 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1052585008082 homodimer interface [polypeptide binding]; other site 1052585008083 motif 1; other site 1052585008084 active site 1052585008085 motif 2; other site 1052585008086 GAD domain; Region: GAD; pfam02938 1052585008087 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1052585008088 motif 3; other site 1052585008089 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1052585008090 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1052585008091 dimer interface [polypeptide binding]; other site 1052585008092 motif 1; other site 1052585008093 active site 1052585008094 motif 2; other site 1052585008095 motif 3; other site 1052585008096 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1052585008097 anticodon binding site; other site 1052585008098 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1052585008099 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1052585008100 Bacterial SH3 domain; Region: SH3_3; pfam08239 1052585008101 Bacterial SH3 domain; Region: SH3_3; pfam08239 1052585008102 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1052585008103 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1052585008104 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052585008105 active site 1052585008106 metal binding site [ion binding]; metal-binding site 1052585008107 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1052585008108 putative active site [active] 1052585008109 dimerization interface [polypeptide binding]; other site 1052585008110 putative tRNAtyr binding site [nucleotide binding]; other site 1052585008111 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1052585008112 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052585008113 Zn2+ binding site [ion binding]; other site 1052585008114 Mg2+ binding site [ion binding]; other site 1052585008115 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052585008116 synthetase active site [active] 1052585008117 NTP binding site [chemical binding]; other site 1052585008118 metal binding site [ion binding]; metal-binding site 1052585008119 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1052585008120 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1052585008121 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585008122 active site 1052585008123 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1052585008124 DHH family; Region: DHH; pfam01368 1052585008125 DHHA1 domain; Region: DHHA1; pfam02272 1052585008126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1052585008127 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1052585008128 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1052585008129 TrkA-C domain; Region: TrkA_C; pfam02080 1052585008130 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1052585008131 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1052585008132 Protein export membrane protein; Region: SecD_SecF; pfam02355 1052585008133 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1052585008134 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1052585008135 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1052585008136 Predicted membrane protein [Function unknown]; Region: COG2323 1052585008137 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1052585008138 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1052585008139 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1052585008140 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1052585008141 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1052585008142 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1052585008143 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1052585008144 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1052585008145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585008146 Walker A motif; other site 1052585008147 ATP binding site [chemical binding]; other site 1052585008148 Walker B motif; other site 1052585008149 arginine finger; other site 1052585008150 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1052585008151 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1052585008152 RuvA N terminal domain; Region: RuvA_N; pfam01330 1052585008153 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1052585008154 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1052585008155 BofC C-terminal domain; Region: BofC_C; pfam08955 1052585008156 polyol permease family; Region: 2A0118; TIGR00897 1052585008157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585008158 putative substrate translocation pore; other site 1052585008159 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585008160 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052585008161 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052585008162 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1052585008163 active site 1052585008164 ATP binding site [chemical binding]; other site 1052585008165 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052585008166 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1052585008167 hypothetical protein; Validated; Region: PRK00110 1052585008168 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585008169 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1052585008170 quinolinate synthetase; Provisional; Region: PRK09375 1052585008171 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1052585008172 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1052585008173 dimerization interface [polypeptide binding]; other site 1052585008174 active site 1052585008175 L-aspartate oxidase; Provisional; Region: PRK08071 1052585008176 L-aspartate oxidase; Provisional; Region: PRK06175 1052585008177 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1052585008178 cysteine desulfurase; Provisional; Region: PRK02948 1052585008179 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1052585008180 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585008181 catalytic residue [active] 1052585008182 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1052585008183 HTH domain; Region: HTH_11; pfam08279 1052585008184 3H domain; Region: 3H; pfam02829 1052585008185 prephenate dehydratase; Provisional; Region: PRK11898 1052585008186 Prephenate dehydratase; Region: PDT; pfam00800 1052585008187 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1052585008188 putative L-Phe binding site [chemical binding]; other site 1052585008189 hypothetical protein; Provisional; Region: PRK04435 1052585008190 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1052585008191 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1052585008192 GTP1/OBG; Region: GTP1_OBG; pfam01018 1052585008193 Obg GTPase; Region: Obg; cd01898 1052585008194 G1 box; other site 1052585008195 GTP/Mg2+ binding site [chemical binding]; other site 1052585008196 Switch I region; other site 1052585008197 G2 box; other site 1052585008198 G3 box; other site 1052585008199 Switch II region; other site 1052585008200 G4 box; other site 1052585008201 G5 box; other site 1052585008202 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1052585008203 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052585008204 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1052585008205 hypothetical protein; Provisional; Region: PRK14553 1052585008206 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1052585008207 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1052585008208 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1052585008209 active site 1052585008210 Peptidase family M50; Region: Peptidase_M50; pfam02163 1052585008211 putative substrate binding region [chemical binding]; other site 1052585008212 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1052585008213 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052585008214 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1052585008215 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1052585008216 Switch I; other site 1052585008217 Switch II; other site 1052585008218 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1052585008219 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1052585008220 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1052585008221 rod shape-determining protein MreC; Region: mreC; TIGR00219 1052585008222 rod shape-determining protein MreC; Region: MreC; pfam04085 1052585008223 rod shape-determining protein MreB; Provisional; Region: PRK13927 1052585008224 MreB and similar proteins; Region: MreB_like; cd10225 1052585008225 nucleotide binding site [chemical binding]; other site 1052585008226 Mg binding site [ion binding]; other site 1052585008227 putative protofilament interaction site [polypeptide binding]; other site 1052585008228 RodZ interaction site [polypeptide binding]; other site 1052585008229 hypothetical protein; Reviewed; Region: PRK00024 1052585008230 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1052585008231 MPN+ (JAMM) motif; other site 1052585008232 Zinc-binding site [ion binding]; other site 1052585008233 Maf-like protein; Region: Maf; pfam02545 1052585008234 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1052585008235 active site 1052585008236 dimer interface [polypeptide binding]; other site 1052585008237 Sporulation related domain; Region: SPOR; pfam05036 1052585008238 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1052585008239 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1052585008240 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052585008241 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052585008242 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1052585008243 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052585008244 active site 1052585008245 HIGH motif; other site 1052585008246 nucleotide binding site [chemical binding]; other site 1052585008247 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1052585008248 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1052585008249 active site 1052585008250 KMSKS motif; other site 1052585008251 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1052585008252 tRNA binding surface [nucleotide binding]; other site 1052585008253 anticodon binding site; other site 1052585008254 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1052585008255 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1052585008256 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1052585008257 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052585008258 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1052585008259 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585008260 inhibitor-cofactor binding pocket; inhibition site 1052585008261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585008262 catalytic residue [active] 1052585008263 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1052585008264 dimer interface [polypeptide binding]; other site 1052585008265 active site 1052585008266 Schiff base residues; other site 1052585008267 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1052585008268 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052585008269 active site 1052585008270 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1052585008271 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1052585008272 domain interfaces; other site 1052585008273 active site 1052585008274 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1052585008275 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1052585008276 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1052585008277 tRNA; other site 1052585008278 putative tRNA binding site [nucleotide binding]; other site 1052585008279 putative NADP binding site [chemical binding]; other site 1052585008280 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1052585008281 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1052585008282 G1 box; other site 1052585008283 GTP/Mg2+ binding site [chemical binding]; other site 1052585008284 Switch I region; other site 1052585008285 G2 box; other site 1052585008286 G3 box; other site 1052585008287 Switch II region; other site 1052585008288 G4 box; other site 1052585008289 G5 box; other site 1052585008290 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1052585008291 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1052585008292 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1052585008293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585008294 Walker A motif; other site 1052585008295 ATP binding site [chemical binding]; other site 1052585008296 Walker B motif; other site 1052585008297 arginine finger; other site 1052585008298 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1052585008299 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1052585008300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585008301 Walker A motif; other site 1052585008302 ATP binding site [chemical binding]; other site 1052585008303 Walker B motif; other site 1052585008304 arginine finger; other site 1052585008305 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1052585008306 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1052585008307 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1052585008308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585008309 Walker A motif; other site 1052585008310 ATP binding site [chemical binding]; other site 1052585008311 Walker B motif; other site 1052585008312 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1052585008313 trigger factor; Provisional; Region: tig; PRK01490 1052585008314 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1052585008315 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1052585008316 TPR repeat; Region: TPR_11; pfam13414 1052585008317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585008318 binding surface 1052585008319 TPR motif; other site 1052585008320 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1052585008321 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1052585008322 hypothetical protein; Provisional; Region: PRK14812 1052585008323 substrate binding site [chemical binding]; other site 1052585008324 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1052585008325 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1052585008326 substrate binding site [chemical binding]; other site 1052585008327 ligand binding site [chemical binding]; other site 1052585008328 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1052585008329 tartrate dehydrogenase; Region: TTC; TIGR02089 1052585008330 2-isopropylmalate synthase; Validated; Region: PRK00915 1052585008331 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1052585008332 active site 1052585008333 metal binding site [ion binding]; metal-binding site 1052585008334 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1052585008335 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1052585008336 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1052585008337 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1052585008338 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1052585008339 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1052585008340 putative valine binding site [chemical binding]; other site 1052585008341 dimer interface [polypeptide binding]; other site 1052585008342 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1052585008343 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1052585008344 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052585008345 PYR/PP interface [polypeptide binding]; other site 1052585008346 dimer interface [polypeptide binding]; other site 1052585008347 TPP binding site [chemical binding]; other site 1052585008348 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1052585008349 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1052585008350 TPP-binding site [chemical binding]; other site 1052585008351 dimer interface [polypeptide binding]; other site 1052585008352 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052585008353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585008354 Coenzyme A binding pocket [chemical binding]; other site 1052585008355 Heat induced stress protein YflT; Region: YflT; pfam11181 1052585008356 conserved domain; Region: TIGR02271 1052585008357 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1052585008358 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052585008359 active site 1052585008360 metal binding site [ion binding]; metal-binding site 1052585008361 homotetramer interface [polypeptide binding]; other site 1052585008362 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1052585008363 active site 1052585008364 dimerization interface [polypeptide binding]; other site 1052585008365 ribonuclease PH; Reviewed; Region: rph; PRK00173 1052585008366 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1052585008367 hexamer interface [polypeptide binding]; other site 1052585008368 active site 1052585008369 Spore germination protein [General function prediction only]; Region: COG5401 1052585008370 Sporulation and spore germination; Region: Germane; pfam10646 1052585008371 Sporulation and spore germination; Region: Germane; pfam10646 1052585008372 glutamate racemase; Region: glut_race; TIGR00067 1052585008373 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585008374 MarR family; Region: MarR; pfam01047 1052585008375 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585008376 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585008377 DNA binding residues [nucleotide binding] 1052585008378 dimerization interface [polypeptide binding]; other site 1052585008379 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1052585008380 active site 1052585008381 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1052585008382 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1052585008383 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1052585008384 L-aspartate oxidase; Provisional; Region: PRK06175 1052585008385 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1052585008386 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1052585008387 putative Iron-sulfur protein interface [polypeptide binding]; other site 1052585008388 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1052585008389 proximal heme binding site [chemical binding]; other site 1052585008390 distal heme binding site [chemical binding]; other site 1052585008391 putative dimer interface [polypeptide binding]; other site 1052585008392 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1052585008393 aspartate kinase; Reviewed; Region: PRK06635 1052585008394 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1052585008395 putative nucleotide binding site [chemical binding]; other site 1052585008396 putative catalytic residues [active] 1052585008397 putative Mg ion binding site [ion binding]; other site 1052585008398 putative aspartate binding site [chemical binding]; other site 1052585008399 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1052585008400 putative allosteric regulatory site; other site 1052585008401 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1052585008402 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1052585008403 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1052585008404 GIY-YIG motif/motif A; other site 1052585008405 active site 1052585008406 catalytic site [active] 1052585008407 putative DNA binding site [nucleotide binding]; other site 1052585008408 metal binding site [ion binding]; metal-binding site 1052585008409 UvrB/uvrC motif; Region: UVR; pfam02151 1052585008410 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1052585008411 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052585008412 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052585008413 catalytic residues [active] 1052585008414 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1052585008415 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1052585008416 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1052585008417 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1052585008418 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1052585008419 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1052585008420 Ligand binding site [chemical binding]; other site 1052585008421 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1052585008422 enoyl-CoA hydratase; Provisional; Region: PRK07658 1052585008423 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585008424 substrate binding site [chemical binding]; other site 1052585008425 oxyanion hole (OAH) forming residues; other site 1052585008426 trimer interface [polypeptide binding]; other site 1052585008427 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585008428 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585008429 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1052585008430 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1052585008431 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1052585008432 acyl-activating enzyme (AAE) consensus motif; other site 1052585008433 putative AMP binding site [chemical binding]; other site 1052585008434 putative active site [active] 1052585008435 putative CoA binding site [chemical binding]; other site 1052585008436 Predicted membrane protein [Function unknown]; Region: COG3766 1052585008437 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1052585008438 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1052585008439 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1052585008440 MutS domain III; Region: MutS_III; pfam05192 1052585008441 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1052585008442 Walker A/P-loop; other site 1052585008443 ATP binding site [chemical binding]; other site 1052585008444 Q-loop/lid; other site 1052585008445 ABC transporter signature motif; other site 1052585008446 Walker B; other site 1052585008447 D-loop; other site 1052585008448 H-loop/switch region; other site 1052585008449 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1052585008450 Smr domain; Region: Smr; pfam01713 1052585008451 hypothetical protein; Provisional; Region: PRK08609 1052585008452 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1052585008453 active site 1052585008454 primer binding site [nucleotide binding]; other site 1052585008455 NTP binding site [chemical binding]; other site 1052585008456 metal binding triad [ion binding]; metal-binding site 1052585008457 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1052585008458 active site 1052585008459 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1052585008460 Colicin V production protein; Region: Colicin_V; pfam02674 1052585008461 cell division protein ZapA; Provisional; Region: PRK14126 1052585008462 ribonuclease HIII; Provisional; Region: PRK00996 1052585008463 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1052585008464 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1052585008465 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052585008466 active site 1052585008467 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1052585008468 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1052585008469 putative tRNA-binding site [nucleotide binding]; other site 1052585008470 B3/4 domain; Region: B3_4; pfam03483 1052585008471 tRNA synthetase B5 domain; Region: B5; smart00874 1052585008472 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1052585008473 dimer interface [polypeptide binding]; other site 1052585008474 motif 1; other site 1052585008475 motif 3; other site 1052585008476 motif 2; other site 1052585008477 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1052585008478 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1052585008479 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1052585008480 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1052585008481 dimer interface [polypeptide binding]; other site 1052585008482 motif 1; other site 1052585008483 active site 1052585008484 motif 2; other site 1052585008485 motif 3; other site 1052585008486 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1052585008487 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1052585008488 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1052585008489 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1052585008490 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1052585008491 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1052585008492 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1052585008493 FAD binding domain; Region: FAD_binding_4; pfam01565 1052585008494 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1052585008495 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1052585008496 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1052585008497 Cysteine-rich domain; Region: CCG; pfam02754 1052585008498 Cysteine-rich domain; Region: CCG; pfam02754 1052585008499 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1052585008500 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585008501 active site 1052585008502 metal binding site [ion binding]; metal-binding site 1052585008503 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1052585008504 Carbon starvation protein CstA; Region: CstA; pfam02554 1052585008505 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1052585008506 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1052585008507 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052585008508 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1052585008509 Predicted transcriptional regulators [Transcription]; Region: COG1695 1052585008510 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1052585008511 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1052585008512 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1052585008513 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585008514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585008515 putative PBP binding loops; other site 1052585008516 dimer interface [polypeptide binding]; other site 1052585008517 ABC-ATPase subunit interface; other site 1052585008518 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052585008519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585008520 dimer interface [polypeptide binding]; other site 1052585008521 conserved gate region; other site 1052585008522 putative PBP binding loops; other site 1052585008523 ABC-ATPase subunit interface; other site 1052585008524 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052585008525 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052585008526 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1052585008527 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1052585008528 active site 1052585008529 metal binding site [ion binding]; metal-binding site 1052585008530 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1052585008531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585008532 active site 1052585008533 motif I; other site 1052585008534 motif II; other site 1052585008535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585008536 motif II; other site 1052585008537 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1052585008538 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1052585008539 intersubunit interface [polypeptide binding]; other site 1052585008540 active site 1052585008541 Zn2+ binding site [ion binding]; other site 1052585008542 L-ribulokinase; Region: L-ribulokinase; TIGR01234 1052585008543 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1052585008544 N- and C-terminal domain interface [polypeptide binding]; other site 1052585008545 active site 1052585008546 MgATP binding site [chemical binding]; other site 1052585008547 catalytic site [active] 1052585008548 metal binding site [ion binding]; metal-binding site 1052585008549 carbohydrate binding site [chemical binding]; other site 1052585008550 homodimer interface [polypeptide binding]; other site 1052585008551 L-arabinose isomerase; Provisional; Region: PRK02929 1052585008552 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1052585008553 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052585008554 trimer interface [polypeptide binding]; other site 1052585008555 putative substrate binding site [chemical binding]; other site 1052585008556 putative metal binding site [ion binding]; other site 1052585008557 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1052585008558 substrate binding site [chemical binding]; other site 1052585008559 active site 1052585008560 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052585008561 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1052585008562 oligomer interface [polypeptide binding]; other site 1052585008563 active site 1052585008564 metal binding site [ion binding]; metal-binding site 1052585008565 Predicted membrane protein [Function unknown]; Region: COG3326 1052585008566 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1052585008567 23S rRNA binding site [nucleotide binding]; other site 1052585008568 L21 binding site [polypeptide binding]; other site 1052585008569 L13 binding site [polypeptide binding]; other site 1052585008570 translation initiation factor IF-3; Region: infC; TIGR00168 1052585008571 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1052585008572 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1052585008573 antiholin-like protein LrgB; Provisional; Region: PRK04288 1052585008574 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1052585008575 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1052585008576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585008577 active site 1052585008578 phosphorylation site [posttranslational modification] 1052585008579 intermolecular recognition site; other site 1052585008580 dimerization interface [polypeptide binding]; other site 1052585008581 LytTr DNA-binding domain; Region: LytTR; pfam04397 1052585008582 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1052585008583 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1052585008584 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1052585008585 Histidine kinase; Region: His_kinase; pfam06580 1052585008586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585008587 ATP binding site [chemical binding]; other site 1052585008588 Mg2+ binding site [ion binding]; other site 1052585008589 G-X-G motif; other site 1052585008590 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1052585008591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585008592 motif II; other site 1052585008593 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1052585008594 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1052585008595 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1052585008596 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1052585008597 active site 1052585008598 dimer interface [polypeptide binding]; other site 1052585008599 motif 1; other site 1052585008600 motif 2; other site 1052585008601 motif 3; other site 1052585008602 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1052585008603 anticodon binding site; other site 1052585008604 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1052585008605 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052585008606 primosomal protein DnaI; Reviewed; Region: PRK08939 1052585008607 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1052585008608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585008609 Walker A motif; other site 1052585008610 ATP binding site [chemical binding]; other site 1052585008611 Walker B motif; other site 1052585008612 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1052585008613 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1052585008614 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1052585008615 ATP cone domain; Region: ATP-cone; pfam03477 1052585008616 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1052585008617 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1052585008618 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1052585008619 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1052585008620 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052585008621 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052585008622 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052585008623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585008624 putative substrate translocation pore; other site 1052585008625 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585008626 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052585008627 active site 1052585008628 catalytic tetrad [active] 1052585008629 dephospho-CoA kinase; Region: TIGR00152 1052585008630 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1052585008631 CoA-binding site [chemical binding]; other site 1052585008632 ATP-binding [chemical binding]; other site 1052585008633 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1052585008634 Domain of unknown function DUF; Region: DUF204; pfam02659 1052585008635 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1052585008636 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1052585008637 DNA binding site [nucleotide binding] 1052585008638 catalytic residue [active] 1052585008639 H2TH interface [polypeptide binding]; other site 1052585008640 putative catalytic residues [active] 1052585008641 turnover-facilitating residue; other site 1052585008642 intercalation triad [nucleotide binding]; other site 1052585008643 8OG recognition residue [nucleotide binding]; other site 1052585008644 putative reading head residues; other site 1052585008645 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1052585008646 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1052585008647 DNA polymerase I; Provisional; Region: PRK05755 1052585008648 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1052585008649 active site 1052585008650 metal binding site 1 [ion binding]; metal-binding site 1052585008651 putative 5' ssDNA interaction site; other site 1052585008652 metal binding site 3; metal-binding site 1052585008653 metal binding site 2 [ion binding]; metal-binding site 1052585008654 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1052585008655 putative DNA binding site [nucleotide binding]; other site 1052585008656 putative metal binding site [ion binding]; other site 1052585008657 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1052585008658 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1052585008659 active site 1052585008660 DNA binding site [nucleotide binding] 1052585008661 catalytic site [active] 1052585008662 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052585008663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585008664 putative active site [active] 1052585008665 heme pocket [chemical binding]; other site 1052585008666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585008667 dimer interface [polypeptide binding]; other site 1052585008668 phosphorylation site [posttranslational modification] 1052585008669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585008670 ATP binding site [chemical binding]; other site 1052585008671 Mg2+ binding site [ion binding]; other site 1052585008672 G-X-G motif; other site 1052585008673 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585008674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585008675 active site 1052585008676 phosphorylation site [posttranslational modification] 1052585008677 intermolecular recognition site; other site 1052585008678 dimerization interface [polypeptide binding]; other site 1052585008679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585008680 DNA binding site [nucleotide binding] 1052585008681 malate dehydrogenase; Reviewed; Region: PRK06223 1052585008682 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1052585008683 NAD(P) binding site [chemical binding]; other site 1052585008684 dimer interface [polypeptide binding]; other site 1052585008685 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585008686 substrate binding site [chemical binding]; other site 1052585008687 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1052585008688 isocitrate dehydrogenase; Validated; Region: PRK07362 1052585008689 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1052585008690 dimer interface [polypeptide binding]; other site 1052585008691 Citrate synthase; Region: Citrate_synt; pfam00285 1052585008692 active site 1052585008693 citrylCoA binding site [chemical binding]; other site 1052585008694 oxalacetate/citrate binding site [chemical binding]; other site 1052585008695 coenzyme A binding site [chemical binding]; other site 1052585008696 catalytic triad [active] 1052585008697 Predicted membrane protein [Function unknown]; Region: COG2707 1052585008698 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1052585008699 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052585008700 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1052585008701 pyruvate kinase; Provisional; Region: PRK06354 1052585008702 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1052585008703 active site 1052585008704 domain interfaces; other site 1052585008705 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1052585008706 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1052585008707 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1052585008708 active site 1052585008709 ADP/pyrophosphate binding site [chemical binding]; other site 1052585008710 dimerization interface [polypeptide binding]; other site 1052585008711 allosteric effector site; other site 1052585008712 fructose-1,6-bisphosphate binding site; other site 1052585008713 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1052585008714 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1052585008715 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1052585008716 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1052585008717 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1052585008718 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1052585008719 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052585008720 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1052585008721 putative NAD(P) binding site [chemical binding]; other site 1052585008722 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1052585008723 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1052585008724 active site 1052585008725 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1052585008726 generic binding surface I; other site 1052585008727 generic binding surface II; other site 1052585008728 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1052585008729 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1052585008730 DHH family; Region: DHH; pfam01368 1052585008731 DHHA1 domain; Region: DHHA1; pfam02272 1052585008732 YtpI-like protein; Region: YtpI; pfam14007 1052585008733 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1052585008734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585008735 DNA-binding site [nucleotide binding]; DNA binding site 1052585008736 DRTGG domain; Region: DRTGG; pfam07085 1052585008737 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1052585008738 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1052585008739 active site 2 [active] 1052585008740 active site 1 [active] 1052585008741 metal-dependent hydrolase; Provisional; Region: PRK00685 1052585008742 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1052585008743 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1052585008744 classical (c) SDRs; Region: SDR_c; cd05233 1052585008745 NAD(P) binding site [chemical binding]; other site 1052585008746 active site 1052585008747 argininosuccinate lyase; Provisional; Region: PRK00855 1052585008748 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1052585008749 active sites [active] 1052585008750 tetramer interface [polypeptide binding]; other site 1052585008751 argininosuccinate synthase; Provisional; Region: PRK13820 1052585008752 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1052585008753 ANP binding site [chemical binding]; other site 1052585008754 Substrate Binding Site II [chemical binding]; other site 1052585008755 Substrate Binding Site I [chemical binding]; other site 1052585008756 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1052585008757 MPT binding site; other site 1052585008758 trimer interface [polypeptide binding]; other site 1052585008759 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1052585008760 propionate/acetate kinase; Provisional; Region: PRK12379 1052585008761 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1052585008762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585008763 S-adenosylmethionine binding site [chemical binding]; other site 1052585008764 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1052585008765 dimer interface [polypeptide binding]; other site 1052585008766 catalytic triad [active] 1052585008767 peroxidatic and resolving cysteines [active] 1052585008768 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1052585008769 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1052585008770 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1052585008771 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1052585008772 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1052585008773 tandem repeat interface [polypeptide binding]; other site 1052585008774 oligomer interface [polypeptide binding]; other site 1052585008775 active site residues [active] 1052585008776 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1052585008777 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1052585008778 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1052585008779 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1052585008780 active site 1052585008781 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1052585008782 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1052585008783 active site 1052585008784 acyl-activating enzyme (AAE) consensus motif; other site 1052585008785 putative CoA binding site [chemical binding]; other site 1052585008786 AMP binding site [chemical binding]; other site 1052585008787 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052585008788 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1052585008789 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1052585008790 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1052585008791 Ligand Binding Site [chemical binding]; other site 1052585008792 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1052585008793 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1052585008794 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585008795 catalytic residue [active] 1052585008796 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1052585008797 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1052585008798 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1052585008799 oligomer interface [polypeptide binding]; other site 1052585008800 histidinol-phosphatase; Reviewed; Region: PRK08123 1052585008801 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1052585008802 active site 1052585008803 dimer interface [polypeptide binding]; other site 1052585008804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585008805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585008806 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1052585008807 GAF domain; Region: GAF_2; pfam13185 1052585008808 GAF domain; Region: GAF_2; pfam13185 1052585008809 GAF domain; Region: GAF_3; pfam13492 1052585008810 GAF domain; Region: GAF_3; pfam13492 1052585008811 GAF domain; Region: GAF_2; pfam13185 1052585008812 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052585008813 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052585008814 metal binding site [ion binding]; metal-binding site 1052585008815 active site 1052585008816 I-site; other site 1052585008817 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1052585008818 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1052585008819 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585008820 RNA binding surface [nucleotide binding]; other site 1052585008821 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1052585008822 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1052585008823 active site 1052585008824 HIGH motif; other site 1052585008825 dimer interface [polypeptide binding]; other site 1052585008826 KMSKS motif; other site 1052585008827 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585008828 RNA binding surface [nucleotide binding]; other site 1052585008829 acetyl-CoA synthetase; Provisional; Region: PRK04319 1052585008830 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1052585008831 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1052585008832 active site 1052585008833 acyl-activating enzyme (AAE) consensus motif; other site 1052585008834 putative CoA binding site [chemical binding]; other site 1052585008835 AMP binding site [chemical binding]; other site 1052585008836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585008837 Coenzyme A binding pocket [chemical binding]; other site 1052585008838 FOG: CBS domain [General function prediction only]; Region: COG0517 1052585008839 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1052585008840 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1052585008841 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1052585008842 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1052585008843 active site 1052585008844 Zn binding site [ion binding]; other site 1052585008845 flagellar motor protein MotS; Reviewed; Region: PRK06925 1052585008846 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1052585008847 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1052585008848 ligand binding site [chemical binding]; other site 1052585008849 flagellar motor protein MotP; Reviewed; Region: PRK06926 1052585008850 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1052585008851 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1052585008852 dimerization interface [polypeptide binding]; other site 1052585008853 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1052585008854 effector binding site; other site 1052585008855 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1052585008856 chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801 1052585008857 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1052585008858 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 1052585008859 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1052585008860 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1052585008861 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1052585008862 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1052585008863 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052585008864 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052585008865 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1052585008866 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052585008867 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1052585008868 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1052585008869 putative tRNA-binding site [nucleotide binding]; other site 1052585008870 hypothetical protein; Provisional; Region: PRK13668 1052585008871 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052585008872 catalytic residues [active] 1052585008873 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1052585008874 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052585008875 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1052585008876 oligomer interface [polypeptide binding]; other site 1052585008877 active site 1052585008878 metal binding site [ion binding]; metal-binding site 1052585008879 Predicted small secreted protein [Function unknown]; Region: COG5584 1052585008880 malate dehydrogenase; Provisional; Region: PRK13529 1052585008881 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052585008882 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1052585008883 NAD(P) binding site [chemical binding]; other site 1052585008884 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1052585008885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585008886 S-adenosylmethionine binding site [chemical binding]; other site 1052585008887 YtzH-like protein; Region: YtzH; pfam14165 1052585008888 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1052585008889 active site 1052585008890 ATP binding site [chemical binding]; other site 1052585008891 Phosphotransferase enzyme family; Region: APH; pfam01636 1052585008892 substrate binding site [chemical binding]; other site 1052585008893 pullulanase, type I; Region: pulA_typeI; TIGR02104 1052585008894 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1052585008895 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1052585008896 Ca binding site [ion binding]; other site 1052585008897 active site 1052585008898 catalytic site [active] 1052585008899 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1052585008900 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1052585008901 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1052585008902 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052585008903 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052585008904 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052585008905 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052585008906 dimer interface [polypeptide binding]; other site 1052585008907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585008908 catalytic residue [active] 1052585008909 dipeptidase PepV; Reviewed; Region: PRK07318 1052585008910 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1052585008911 active site 1052585008912 metal binding site [ion binding]; metal-binding site 1052585008913 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1052585008914 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1052585008915 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052585008916 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052585008917 Walker A/P-loop; other site 1052585008918 ATP binding site [chemical binding]; other site 1052585008919 Q-loop/lid; other site 1052585008920 ABC transporter signature motif; other site 1052585008921 Walker B; other site 1052585008922 D-loop; other site 1052585008923 H-loop/switch region; other site 1052585008924 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1052585008925 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1052585008926 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585008927 RNA binding surface [nucleotide binding]; other site 1052585008928 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1052585008929 active site 1052585008930 uracil binding [chemical binding]; other site 1052585008931 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052585008932 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1052585008933 Predicted flavoproteins [General function prediction only]; Region: COG2081 1052585008934 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052585008935 BCCT family transporter; Region: BCCT; cl00569 1052585008936 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1052585008937 Predicted integral membrane protein [Function unknown]; Region: COG5578 1052585008938 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052585008939 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585008940 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052585008941 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1052585008942 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052585008943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585008944 dimer interface [polypeptide binding]; other site 1052585008945 conserved gate region; other site 1052585008946 ABC-ATPase subunit interface; other site 1052585008947 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1052585008948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585008949 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585008950 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585008951 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052585008952 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585008953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585008954 dimer interface [polypeptide binding]; other site 1052585008955 conserved gate region; other site 1052585008956 putative PBP binding loops; other site 1052585008957 ABC-ATPase subunit interface; other site 1052585008958 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052585008959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008960 NAD(P) binding site [chemical binding]; other site 1052585008961 active site 1052585008962 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052585008963 Cytochrome P450; Region: p450; cl12078 1052585008964 biotin synthase; Validated; Region: PRK06256 1052585008965 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585008966 FeS/SAM binding site; other site 1052585008967 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1052585008968 AAA domain; Region: AAA_26; pfam13500 1052585008969 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1052585008970 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1052585008971 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1052585008972 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1052585008973 substrate-cofactor binding pocket; other site 1052585008974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585008975 catalytic residue [active] 1052585008976 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1052585008977 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585008978 inhibitor-cofactor binding pocket; inhibition site 1052585008979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585008980 catalytic residue [active] 1052585008981 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1052585008982 Abhydrolase family; Region: Abhydrolase_7; pfam12715 1052585008983 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585008984 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585008985 DNA binding site [nucleotide binding] 1052585008986 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1052585008987 putative ligand binding site [chemical binding]; other site 1052585008988 putative dimerization interface [polypeptide binding]; other site 1052585008989 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052585008990 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052585008991 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052585008992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585008993 dimer interface [polypeptide binding]; other site 1052585008994 conserved gate region; other site 1052585008995 putative PBP binding loops; other site 1052585008996 ABC-ATPase subunit interface; other site 1052585008997 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585008998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585008999 dimer interface [polypeptide binding]; other site 1052585009000 conserved gate region; other site 1052585009001 putative PBP binding loops; other site 1052585009002 ABC-ATPase subunit interface; other site 1052585009003 alpha-galactosidase; Provisional; Region: PRK15076 1052585009004 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1052585009005 NAD binding site [chemical binding]; other site 1052585009006 sugar binding site [chemical binding]; other site 1052585009007 divalent metal binding site [ion binding]; other site 1052585009008 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585009009 dimer interface [polypeptide binding]; other site 1052585009010 Homeodomain-like domain; Region: HTH_23; pfam13384 1052585009011 putative transposase OrfB; Reviewed; Region: PHA02517 1052585009012 HTH-like domain; Region: HTH_21; pfam13276 1052585009013 Integrase core domain; Region: rve; pfam00665 1052585009014 Integrase core domain; Region: rve_3; pfam13683 1052585009015 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052585009016 active site residue [active] 1052585009017 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1052585009018 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1052585009019 HIGH motif; other site 1052585009020 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1052585009021 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052585009022 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1052585009023 active site 1052585009024 KMSKS motif; other site 1052585009025 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1052585009026 tRNA binding surface [nucleotide binding]; other site 1052585009027 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1052585009028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585009029 PAS domain; Region: PAS_9; pfam13426 1052585009030 putative active site [active] 1052585009031 heme pocket [chemical binding]; other site 1052585009032 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585009033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585009034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585009035 putative substrate translocation pore; other site 1052585009036 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1052585009037 Centromere protein H (CENP-H); Region: CENP-H; pfam05837 1052585009038 FtsX-like permease family; Region: FtsX; pfam02687 1052585009039 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585009040 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052585009041 Walker A/P-loop; other site 1052585009042 ATP binding site [chemical binding]; other site 1052585009043 Q-loop/lid; other site 1052585009044 ABC transporter signature motif; other site 1052585009045 Walker B; other site 1052585009046 D-loop; other site 1052585009047 H-loop/switch region; other site 1052585009048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585009049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585009050 ATP binding site [chemical binding]; other site 1052585009051 Mg2+ binding site [ion binding]; other site 1052585009052 G-X-G motif; other site 1052585009053 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585009054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585009055 active site 1052585009056 phosphorylation site [posttranslational modification] 1052585009057 intermolecular recognition site; other site 1052585009058 dimerization interface [polypeptide binding]; other site 1052585009059 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585009060 DNA binding site [nucleotide binding] 1052585009061 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052585009062 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052585009063 FtsX-like permease family; Region: FtsX; pfam02687 1052585009064 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585009065 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052585009066 Walker A/P-loop; other site 1052585009067 ATP binding site [chemical binding]; other site 1052585009068 Q-loop/lid; other site 1052585009069 ABC transporter signature motif; other site 1052585009070 Walker B; other site 1052585009071 D-loop; other site 1052585009072 H-loop/switch region; other site 1052585009073 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1052585009074 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1052585009075 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585009076 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052585009077 Walker A/P-loop; other site 1052585009078 ATP binding site [chemical binding]; other site 1052585009079 Q-loop/lid; other site 1052585009080 ABC transporter signature motif; other site 1052585009081 Walker B; other site 1052585009082 D-loop; other site 1052585009083 H-loop/switch region; other site 1052585009084 Predicted transcriptional regulators [Transcription]; Region: COG1725 1052585009085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585009086 DNA-binding site [nucleotide binding]; DNA binding site 1052585009087 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1052585009088 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1052585009089 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1052585009090 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1052585009091 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1052585009092 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052585009093 PGAP1-like protein; Region: PGAP1; pfam07819 1052585009094 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1052585009095 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1052585009096 trimer interface [polypeptide binding]; other site 1052585009097 putative metal binding site [ion binding]; other site 1052585009098 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052585009099 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1052585009100 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1052585009101 active site 1052585009102 dimer interface [polypeptide binding]; other site 1052585009103 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1052585009104 Ligand Binding Site [chemical binding]; other site 1052585009105 Molecular Tunnel; other site 1052585009106 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1052585009107 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1052585009108 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1052585009109 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1052585009110 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1052585009111 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1052585009112 active site 1052585009113 substrate-binding site [chemical binding]; other site 1052585009114 metal-binding site [ion binding] 1052585009115 ATP binding site [chemical binding]; other site 1052585009116 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1052585009117 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1052585009118 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052585009119 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1052585009120 NMT1-like family; Region: NMT1_2; pfam13379 1052585009121 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1052585009122 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1052585009123 Walker A/P-loop; other site 1052585009124 ATP binding site [chemical binding]; other site 1052585009125 Q-loop/lid; other site 1052585009126 ABC transporter signature motif; other site 1052585009127 Walker B; other site 1052585009128 D-loop; other site 1052585009129 H-loop/switch region; other site 1052585009130 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1052585009131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009132 dimer interface [polypeptide binding]; other site 1052585009133 conserved gate region; other site 1052585009134 putative PBP binding loops; other site 1052585009135 ABC-ATPase subunit interface; other site 1052585009136 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1052585009137 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1052585009138 nudix motif; other site 1052585009139 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1052585009140 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1052585009141 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1052585009142 dimerization interface [polypeptide binding]; other site 1052585009143 DPS ferroxidase diiron center [ion binding]; other site 1052585009144 ion pore; other site 1052585009145 YtkA-like; Region: YtkA; pfam13115 1052585009146 S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664 1052585009147 Haemolytic domain; Region: Haemolytic; pfam01809 1052585009148 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1052585009149 active site clefts [active] 1052585009150 zinc binding site [ion binding]; other site 1052585009151 dimer interface [polypeptide binding]; other site 1052585009152 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1052585009153 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1052585009154 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1052585009155 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1052585009156 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1052585009157 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585009158 ABC-ATPase subunit interface; other site 1052585009159 dimer interface [polypeptide binding]; other site 1052585009160 putative PBP binding regions; other site 1052585009161 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1052585009162 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585009163 ABC-ATPase subunit interface; other site 1052585009164 dimer interface [polypeptide binding]; other site 1052585009165 putative PBP binding regions; other site 1052585009166 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052585009167 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1052585009168 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1052585009169 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 1052585009170 metal binding site [ion binding]; metal-binding site 1052585009171 intersubunit interface [polypeptide binding]; other site 1052585009172 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1052585009173 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1052585009174 active site 1052585009175 octamer interface [polypeptide binding]; other site 1052585009176 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1052585009177 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1052585009178 acyl-activating enzyme (AAE) consensus motif; other site 1052585009179 putative AMP binding site [chemical binding]; other site 1052585009180 putative active site [active] 1052585009181 putative CoA binding site [chemical binding]; other site 1052585009182 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585009183 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052585009184 substrate binding site [chemical binding]; other site 1052585009185 oxyanion hole (OAH) forming residues; other site 1052585009186 trimer interface [polypeptide binding]; other site 1052585009187 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1052585009188 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1052585009189 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1052585009190 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1052585009191 dimer interface [polypeptide binding]; other site 1052585009192 tetramer interface [polypeptide binding]; other site 1052585009193 PYR/PP interface [polypeptide binding]; other site 1052585009194 TPP binding site [chemical binding]; other site 1052585009195 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1052585009196 TPP-binding site; other site 1052585009197 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1052585009198 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1052585009199 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 1052585009200 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052585009201 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1052585009202 active site 1052585009203 tetramer interface; other site 1052585009204 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1052585009205 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1052585009206 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052585009207 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1052585009208 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052585009209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585009210 NAD(P) binding site [chemical binding]; other site 1052585009211 active site 1052585009212 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585009213 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052585009214 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1052585009215 spore coat protein YutH; Region: spore_yutH; TIGR02905 1052585009216 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585009217 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052585009218 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1052585009219 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1052585009220 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 1052585009221 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1052585009222 homodimer interface [polypeptide binding]; other site 1052585009223 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1052585009224 active site pocket [active] 1052585009225 glycogen synthase; Provisional; Region: glgA; PRK00654 1052585009226 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1052585009227 ADP-binding pocket [chemical binding]; other site 1052585009228 homodimer interface [polypeptide binding]; other site 1052585009229 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1052585009230 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1052585009231 ligand binding site; other site 1052585009232 oligomer interface; other site 1052585009233 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1052585009234 dimer interface [polypeptide binding]; other site 1052585009235 N-terminal domain interface [polypeptide binding]; other site 1052585009236 sulfate 1 binding site; other site 1052585009237 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1052585009238 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1052585009239 ligand binding site; other site 1052585009240 oligomer interface; other site 1052585009241 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1052585009242 dimer interface [polypeptide binding]; other site 1052585009243 N-terminal domain interface [polypeptide binding]; other site 1052585009244 sulfate 1 binding site; other site 1052585009245 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 1052585009246 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1052585009247 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1052585009248 active site 1052585009249 catalytic site [active] 1052585009250 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1052585009251 Predicted membrane protein [Function unknown]; Region: COG3859 1052585009252 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052585009253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585009254 Coenzyme A binding pocket [chemical binding]; other site 1052585009255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1052585009256 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1052585009257 DinB superfamily; Region: DinB_2; pfam12867 1052585009258 metal-dependent hydrolase; Provisional; Region: PRK13291 1052585009259 MOSC domain; Region: MOSC; pfam03473 1052585009260 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1052585009261 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1052585009262 active site 1052585009263 NAD binding site [chemical binding]; other site 1052585009264 metal binding site [ion binding]; metal-binding site 1052585009265 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1052585009266 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1052585009267 tetramerization interface [polypeptide binding]; other site 1052585009268 NAD(P) binding site [chemical binding]; other site 1052585009269 catalytic residues [active] 1052585009270 Predicted transcriptional regulators [Transcription]; Region: COG1510 1052585009271 MarR family; Region: MarR_2; pfam12802 1052585009272 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052585009273 TrkA-N domain; Region: TrkA_N; pfam02254 1052585009274 TrkA-C domain; Region: TrkA_C; pfam02080 1052585009275 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1052585009276 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1052585009277 Predicted membrane protein [Function unknown]; Region: COG4682 1052585009278 yiaA/B two helix domain; Region: YiaAB; pfam05360 1052585009279 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1052585009280 SH3-like domain; Region: SH3_8; pfam13457 1052585009281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585009282 putative substrate translocation pore; other site 1052585009283 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585009284 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052585009285 DNA binding site [nucleotide binding] 1052585009286 active site 1052585009287 Int/Topo IB signature motif; other site 1052585009288 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1052585009289 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052585009290 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1052585009291 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585009292 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052585009293 L-rhamnose isomerase; Provisional; Region: PRK01076 1052585009294 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1052585009295 Domain of unknown function (DUF718); Region: DUF718; cl01281 1052585009296 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1052585009297 N- and C-terminal domain interface [polypeptide binding]; other site 1052585009298 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1052585009299 active site 1052585009300 putative catalytic site [active] 1052585009301 metal binding site [ion binding]; metal-binding site 1052585009302 ATP binding site [chemical binding]; other site 1052585009303 carbohydrate binding site [chemical binding]; other site 1052585009304 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052585009305 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1052585009306 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1052585009307 short chain dehydrogenase; Validated; Region: PRK08324 1052585009308 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1052585009309 active site 1052585009310 intersubunit interface [polypeptide binding]; other site 1052585009311 Zn2+ binding site [ion binding]; other site 1052585009312 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1052585009313 putative NAD(P) binding site [chemical binding]; other site 1052585009314 active site 1052585009315 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1052585009316 Cache domain; Region: Cache_1; pfam02743 1052585009317 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585009318 dimerization interface [polypeptide binding]; other site 1052585009319 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585009320 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585009321 dimer interface [polypeptide binding]; other site 1052585009322 putative CheW interface [polypeptide binding]; other site 1052585009323 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585009324 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1052585009325 Cache domain; Region: Cache_1; pfam02743 1052585009326 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585009327 dimerization interface [polypeptide binding]; other site 1052585009328 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585009329 dimer interface [polypeptide binding]; other site 1052585009330 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1052585009331 putative CheW interface [polypeptide binding]; other site 1052585009332 Tar ligand binding domain homologue; Region: TarH; pfam02203 1052585009333 Cache domain; Region: Cache_1; pfam02743 1052585009334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585009335 dimerization interface [polypeptide binding]; other site 1052585009336 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585009337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585009338 dimer interface [polypeptide binding]; other site 1052585009339 putative CheW interface [polypeptide binding]; other site 1052585009340 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585009341 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1052585009342 Cache domain; Region: Cache_1; pfam02743 1052585009343 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585009344 dimerization interface [polypeptide binding]; other site 1052585009345 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585009346 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585009347 dimer interface [polypeptide binding]; other site 1052585009348 putative CheW interface [polypeptide binding]; other site 1052585009349 transglutaminase; Provisional; Region: tgl; PRK03187 1052585009350 Nitronate monooxygenase; Region: NMO; pfam03060 1052585009351 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1052585009352 FMN binding site [chemical binding]; other site 1052585009353 substrate binding site [chemical binding]; other site 1052585009354 putative catalytic residue [active] 1052585009355 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1052585009356 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052585009357 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052585009358 Ca binding site [ion binding]; other site 1052585009359 active site 1052585009360 catalytic site [active] 1052585009361 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1052585009362 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052585009363 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052585009364 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052585009365 Transporter associated domain; Region: CorC_HlyC; smart01091 1052585009366 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1052585009367 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1052585009368 Ion channel; Region: Ion_trans_2; pfam07885 1052585009369 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1052585009370 TrkA-N domain; Region: TrkA_N; pfam02254 1052585009371 YugN-like family; Region: YugN; pfam08868 1052585009372 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1052585009373 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1052585009374 active site 1052585009375 dimer interface [polypeptide binding]; other site 1052585009376 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1052585009377 dimer interface [polypeptide binding]; other site 1052585009378 active site 1052585009379 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1052585009380 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1052585009381 dimer interface [polypeptide binding]; other site 1052585009382 active site 1052585009383 metal binding site [ion binding]; metal-binding site 1052585009384 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1052585009385 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1052585009386 dimer interface [polypeptide binding]; other site 1052585009387 active site 1052585009388 metal binding site [ion binding]; metal-binding site 1052585009389 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1052585009390 general stress protein 13; Validated; Region: PRK08059 1052585009391 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1052585009392 RNA binding site [nucleotide binding]; other site 1052585009393 hypothetical protein; Validated; Region: PRK07682 1052585009394 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585009395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585009396 homodimer interface [polypeptide binding]; other site 1052585009397 catalytic residue [active] 1052585009398 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1052585009399 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1052585009400 AsnC family; Region: AsnC_trans_reg; pfam01037 1052585009401 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052585009402 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1052585009403 nucleophilic elbow; other site 1052585009404 catalytic triad; other site 1052585009405 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1052585009406 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1052585009407 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585009408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585009409 homodimer interface [polypeptide binding]; other site 1052585009410 catalytic residue [active] 1052585009411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585009412 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585009413 dimer interface [polypeptide binding]; other site 1052585009414 phosphorylation site [posttranslational modification] 1052585009415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585009416 ATP binding site [chemical binding]; other site 1052585009417 Mg2+ binding site [ion binding]; other site 1052585009418 G-X-G motif; other site 1052585009419 Kinase associated protein B; Region: KapB; pfam08810 1052585009420 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1052585009421 active site 1052585009422 catalytic site [active] 1052585009423 substrate binding site [chemical binding]; other site 1052585009424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585009425 drug efflux system protein MdtG; Provisional; Region: PRK09874 1052585009426 putative substrate translocation pore; other site 1052585009427 Transglycosylase; Region: Transgly; pfam00912 1052585009428 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052585009429 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1052585009430 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1052585009431 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1052585009432 PAS domain; Region: PAS; smart00091 1052585009433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585009434 ATP binding site [chemical binding]; other site 1052585009435 Mg2+ binding site [ion binding]; other site 1052585009436 G-X-G motif; other site 1052585009437 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052585009438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585009439 active site 1052585009440 phosphorylation site [posttranslational modification] 1052585009441 intermolecular recognition site; other site 1052585009442 dimerization interface [polypeptide binding]; other site 1052585009443 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1052585009444 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1052585009445 ligand binding site [chemical binding]; other site 1052585009446 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1052585009447 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1052585009448 Walker A/P-loop; other site 1052585009449 ATP binding site [chemical binding]; other site 1052585009450 Q-loop/lid; other site 1052585009451 ABC transporter signature motif; other site 1052585009452 Walker B; other site 1052585009453 D-loop; other site 1052585009454 H-loop/switch region; other site 1052585009455 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1052585009456 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1052585009457 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1052585009458 TM-ABC transporter signature motif; other site 1052585009459 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1052585009460 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1052585009461 TM-ABC transporter signature motif; other site 1052585009462 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1052585009463 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1052585009464 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1052585009465 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1052585009466 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1052585009467 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1052585009468 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1052585009469 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1052585009470 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1052585009471 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1052585009472 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1052585009473 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1052585009474 CoenzymeA binding site [chemical binding]; other site 1052585009475 subunit interaction site [polypeptide binding]; other site 1052585009476 PHB binding site; other site 1052585009477 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585009478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585009479 active site 1052585009480 phosphorylation site [posttranslational modification] 1052585009481 intermolecular recognition site; other site 1052585009482 dimerization interface [polypeptide binding]; other site 1052585009483 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585009484 DNA binding residues [nucleotide binding] 1052585009485 dimerization interface [polypeptide binding]; other site 1052585009486 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052585009487 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1052585009488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585009489 Histidine kinase; Region: HisKA_3; pfam07730 1052585009490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585009491 ATP binding site [chemical binding]; other site 1052585009492 Mg2+ binding site [ion binding]; other site 1052585009493 G-X-G motif; other site 1052585009494 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1052585009495 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1052585009496 substrate binding pocket [chemical binding]; other site 1052585009497 substrate-Mg2+ binding site; other site 1052585009498 aspartate-rich region 1; other site 1052585009499 DegQ (SacQ) family; Region: DegQ; pfam08181 1052585009500 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1052585009501 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1052585009502 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1052585009503 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1052585009504 active site 1052585009505 Isochorismatase family; Region: Isochorismatase; pfam00857 1052585009506 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1052585009507 catalytic triad [active] 1052585009508 conserved cis-peptide bond; other site 1052585009509 Uncharacterized conserved protein [Function unknown]; Region: COG5506 1052585009510 YueH-like protein; Region: YueH; pfam14166 1052585009511 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052585009512 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1052585009513 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052585009514 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1052585009515 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1052585009516 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052585009517 Zn2+ binding site [ion binding]; other site 1052585009518 Mg2+ binding site [ion binding]; other site 1052585009519 short chain dehydrogenase; Provisional; Region: PRK06924 1052585009520 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1052585009521 NADP binding site [chemical binding]; other site 1052585009522 homodimer interface [polypeptide binding]; other site 1052585009523 active site 1052585009524 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1052585009525 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1052585009526 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1052585009527 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1052585009528 Predicted membrane protein [Function unknown]; Region: COG1511 1052585009529 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 1052585009530 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1052585009531 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052585009532 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052585009533 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052585009534 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1052585009535 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1052585009536 Uncharacterized small protein [Function unknown]; Region: COG5417 1052585009537 Ubiquitin homologues; Region: UBQ; smart00213 1052585009538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1052585009539 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052585009540 CodY GAF-like domain; Region: CodY; pfam06018 1052585009541 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1052585009542 alanine dehydrogenase; Region: alaDH; TIGR00518 1052585009543 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1052585009544 hexamer interface [polypeptide binding]; other site 1052585009545 ligand binding site [chemical binding]; other site 1052585009546 putative active site [active] 1052585009547 NAD(P) binding site [chemical binding]; other site 1052585009548 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1052585009549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1052585009550 Condensation domain; Region: Condensation; pfam00668 1052585009551 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1052585009552 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1052585009553 acyl-activating enzyme (AAE) consensus motif; other site 1052585009554 AMP binding site [chemical binding]; other site 1052585009555 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585009556 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1052585009557 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585009558 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052585009559 acyl-activating enzyme (AAE) consensus motif; other site 1052585009560 AMP binding site [chemical binding]; other site 1052585009561 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052585009562 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1052585009563 hydrophobic substrate binding pocket; other site 1052585009564 Isochorismatase family; Region: Isochorismatase; pfam00857 1052585009565 active site 1052585009566 conserved cis-peptide bond; other site 1052585009567 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1052585009568 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 1052585009569 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1052585009570 acyl-activating enzyme (AAE) consensus motif; other site 1052585009571 active site 1052585009572 AMP binding site [chemical binding]; other site 1052585009573 substrate binding site [chemical binding]; other site 1052585009574 isochorismate synthase DhbC; Validated; Region: PRK06923 1052585009575 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1052585009576 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1052585009577 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1052585009578 putative NAD(P) binding site [chemical binding]; other site 1052585009579 active site 1052585009580 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1052585009581 Putative esterase; Region: Esterase; pfam00756 1052585009582 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1052585009583 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1052585009584 Moco binding site; other site 1052585009585 metal coordination site [ion binding]; other site 1052585009586 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1052585009587 Predicted permease [General function prediction only]; Region: COG2056 1052585009588 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1052585009589 AbgT putative transporter family; Region: ABG_transport; cl17431 1052585009590 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1052585009591 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1052585009592 interface (dimer of trimers) [polypeptide binding]; other site 1052585009593 Substrate-binding/catalytic site; other site 1052585009594 Zn-binding sites [ion binding]; other site 1052585009595 Divergent PAP2 family; Region: DUF212; pfam02681 1052585009596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1052585009597 Putative membrane protein; Region: YuiB; pfam14068 1052585009598 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 1052585009599 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052585009600 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585009601 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1052585009602 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052585009603 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585009604 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1052585009605 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1052585009606 active site 1052585009607 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 1052585009608 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052585009609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585009610 Coenzyme A binding pocket [chemical binding]; other site 1052585009611 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1052585009612 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1052585009613 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1052585009614 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1052585009615 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1052585009616 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1052585009617 Nucleoside recognition; Region: Gate; pfam07670 1052585009618 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1052585009619 hypothetical protein; Provisional; Region: PRK13669 1052585009620 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052585009621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585009622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1052585009623 NifU-like domain; Region: NifU; pfam01106 1052585009624 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1052585009625 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1052585009626 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1052585009627 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052585009628 homoserine kinase; Region: thrB; TIGR00191 1052585009629 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1052585009630 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052585009631 threonine synthase; Reviewed; Region: PRK06721 1052585009632 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1052585009633 homodimer interface [polypeptide binding]; other site 1052585009634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585009635 catalytic residue [active] 1052585009636 homoserine dehydrogenase; Provisional; Region: PRK06349 1052585009637 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1052585009638 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1052585009639 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1052585009640 spore coat protein YutH; Region: spore_yutH; TIGR02905 1052585009641 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1052585009642 tetramer interfaces [polypeptide binding]; other site 1052585009643 binuclear metal-binding site [ion binding]; other site 1052585009644 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1052585009645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585009646 active site 1052585009647 motif I; other site 1052585009648 motif II; other site 1052585009649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585009650 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1052585009651 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1052585009652 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052585009653 lipoyl synthase; Provisional; Region: PRK05481 1052585009654 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585009655 FeS/SAM binding site; other site 1052585009656 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1052585009657 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052585009658 sporulation protein YunB; Region: spo_yunB; TIGR02832 1052585009659 Uncharacterized conserved protein [Function unknown]; Region: COG3377 1052585009660 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1052585009661 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1052585009662 active site 1052585009663 metal binding site [ion binding]; metal-binding site 1052585009664 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052585009665 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1052585009666 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1052585009667 allantoinase; Provisional; Region: PRK06189 1052585009668 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1052585009669 active site 1052585009670 DRTGG domain; Region: DRTGG; pfam07085 1052585009671 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052585009672 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1052585009673 xanthine permease; Region: pbuX; TIGR03173 1052585009674 xanthine permease; Region: pbuX; TIGR03173 1052585009675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1052585009676 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 1052585009677 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1052585009678 active site 1052585009679 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1052585009680 active site 1052585009681 homotetramer interface [polypeptide binding]; other site 1052585009682 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052585009683 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052585009684 catalytic residues [active] 1052585009685 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1052585009686 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1052585009687 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 1052585009688 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1052585009689 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1052585009690 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1052585009691 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1052585009692 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1052585009693 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 1052585009694 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1052585009695 Ligand binding site; other site 1052585009696 metal-binding site 1052585009697 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1052585009698 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1052585009699 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1052585009700 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1052585009701 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585009702 catalytic residue [active] 1052585009703 allantoate amidohydrolase; Reviewed; Region: PRK09290 1052585009704 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1052585009705 active site 1052585009706 metal binding site [ion binding]; metal-binding site 1052585009707 dimer interface [polypeptide binding]; other site 1052585009708 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1052585009709 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1052585009710 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1052585009711 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1052585009712 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1052585009713 Walker A/P-loop; other site 1052585009714 ATP binding site [chemical binding]; other site 1052585009715 Q-loop/lid; other site 1052585009716 ABC transporter signature motif; other site 1052585009717 Walker B; other site 1052585009718 D-loop; other site 1052585009719 H-loop/switch region; other site 1052585009720 TOBE domain; Region: TOBE_2; pfam08402 1052585009721 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1052585009722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585009723 DNA-binding site [nucleotide binding]; DNA binding site 1052585009724 UTRA domain; Region: UTRA; pfam07702 1052585009725 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052585009726 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1052585009727 substrate binding site [chemical binding]; other site 1052585009728 ATP binding site [chemical binding]; other site 1052585009729 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585009730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009731 dimer interface [polypeptide binding]; other site 1052585009732 conserved gate region; other site 1052585009733 putative PBP binding loops; other site 1052585009734 ABC-ATPase subunit interface; other site 1052585009735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009736 dimer interface [polypeptide binding]; other site 1052585009737 conserved gate region; other site 1052585009738 putative PBP binding loops; other site 1052585009739 ABC-ATPase subunit interface; other site 1052585009740 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052585009741 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052585009742 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1052585009743 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1052585009744 putative active site [active] 1052585009745 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1052585009746 dimer interface [polypeptide binding]; other site 1052585009747 active site 1052585009748 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1052585009749 active site 1052585009750 catalytic site [active] 1052585009751 putative DNA binding site [nucleotide binding]; other site 1052585009752 GIY-YIG motif/motif A; other site 1052585009753 metal binding site [ion binding]; metal-binding site 1052585009754 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1052585009755 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1052585009756 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585009757 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1052585009758 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1052585009759 FeS assembly protein SufB; Region: sufB; TIGR01980 1052585009760 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1052585009761 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1052585009762 trimerization site [polypeptide binding]; other site 1052585009763 active site 1052585009764 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1052585009765 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1052585009766 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585009767 catalytic residue [active] 1052585009768 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1052585009769 FeS assembly protein SufD; Region: sufD; TIGR01981 1052585009770 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1052585009771 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1052585009772 Walker A/P-loop; other site 1052585009773 ATP binding site [chemical binding]; other site 1052585009774 Q-loop/lid; other site 1052585009775 ABC transporter signature motif; other site 1052585009776 Walker B; other site 1052585009777 D-loop; other site 1052585009778 H-loop/switch region; other site 1052585009779 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1052585009780 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1052585009781 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1052585009782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009783 dimer interface [polypeptide binding]; other site 1052585009784 conserved gate region; other site 1052585009785 ABC-ATPase subunit interface; other site 1052585009786 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1052585009787 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1052585009788 Walker A/P-loop; other site 1052585009789 ATP binding site [chemical binding]; other site 1052585009790 Q-loop/lid; other site 1052585009791 ABC transporter signature motif; other site 1052585009792 Walker B; other site 1052585009793 D-loop; other site 1052585009794 H-loop/switch region; other site 1052585009795 NIL domain; Region: NIL; pfam09383 1052585009796 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1052585009797 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052585009798 catalytic residues [active] 1052585009799 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1052585009800 putative active site [active] 1052585009801 putative metal binding site [ion binding]; other site 1052585009802 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1052585009803 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1052585009804 lipoyl attachment site [posttranslational modification]; other site 1052585009805 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1052585009806 ArsC family; Region: ArsC; pfam03960 1052585009807 putative ArsC-like catalytic residues; other site 1052585009808 putative TRX-like catalytic residues [active] 1052585009809 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1052585009810 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052585009811 active site 1052585009812 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1052585009813 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1052585009814 dimer interface [polypeptide binding]; other site 1052585009815 active site 1052585009816 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1052585009817 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1052585009818 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1052585009819 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1052585009820 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1052585009821 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585009822 substrate binding site [chemical binding]; other site 1052585009823 oxyanion hole (OAH) forming residues; other site 1052585009824 trimer interface [polypeptide binding]; other site 1052585009825 Proline dehydrogenase; Region: Pro_dh; pfam01619 1052585009826 Coat F domain; Region: Coat_F; pfam07875 1052585009827 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585009828 MarR family; Region: MarR; pfam01047 1052585009829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585009830 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585009831 putative substrate translocation pore; other site 1052585009832 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1052585009833 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1052585009834 classical (c) SDRs; Region: SDR_c; cd05233 1052585009835 NAD(P) binding site [chemical binding]; other site 1052585009836 active site 1052585009837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585009838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585009839 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1052585009840 putative dimerization interface [polypeptide binding]; other site 1052585009841 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1052585009842 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052585009843 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052585009844 Walker A/P-loop; other site 1052585009845 ATP binding site [chemical binding]; other site 1052585009846 Q-loop/lid; other site 1052585009847 ABC transporter signature motif; other site 1052585009848 Walker B; other site 1052585009849 D-loop; other site 1052585009850 H-loop/switch region; other site 1052585009851 YusW-like protein; Region: YusW; pfam14039 1052585009852 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1052585009853 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1052585009854 active site 1052585009855 Zn binding site [ion binding]; other site 1052585009856 short chain dehydrogenase; Provisional; Region: PRK06914 1052585009857 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1052585009858 NADP binding site [chemical binding]; other site 1052585009859 active site 1052585009860 steroid binding site; other site 1052585009861 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1052585009862 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1052585009863 dimerization interface [polypeptide binding]; other site 1052585009864 DPS ferroxidase diiron center [ion binding]; other site 1052585009865 ion pore; other site 1052585009866 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1052585009867 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1052585009868 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052585009869 protein binding site [polypeptide binding]; other site 1052585009870 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585009871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585009872 active site 1052585009873 phosphorylation site [posttranslational modification] 1052585009874 intermolecular recognition site; other site 1052585009875 dimerization interface [polypeptide binding]; other site 1052585009876 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585009877 DNA binding site [nucleotide binding] 1052585009878 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585009879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585009880 dimerization interface [polypeptide binding]; other site 1052585009881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585009882 dimer interface [polypeptide binding]; other site 1052585009883 phosphorylation site [posttranslational modification] 1052585009884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585009885 ATP binding site [chemical binding]; other site 1052585009886 Mg2+ binding site [ion binding]; other site 1052585009887 G-X-G motif; other site 1052585009888 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585009889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585009890 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1052585009891 Class II fumarases; Region: Fumarase_classII; cd01362 1052585009892 active site 1052585009893 tetramer interface [polypeptide binding]; other site 1052585009894 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1052585009895 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052585009896 Spore germination protein; Region: Spore_permease; pfam03845 1052585009897 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052585009898 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052585009899 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585009900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585009901 active site 1052585009902 phosphorylation site [posttranslational modification] 1052585009903 intermolecular recognition site; other site 1052585009904 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585009905 DNA binding residues [nucleotide binding] 1052585009906 dimerization interface [polypeptide binding]; other site 1052585009907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585009908 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585009909 dimerization interface [polypeptide binding]; other site 1052585009910 Histidine kinase; Region: HisKA_3; pfam07730 1052585009911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585009912 ATP binding site [chemical binding]; other site 1052585009913 Mg2+ binding site [ion binding]; other site 1052585009914 G-X-G motif; other site 1052585009915 Predicted membrane protein [Function unknown]; Region: COG4758 1052585009916 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1052585009917 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1052585009918 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052585009919 PspA/IM30 family; Region: PspA_IM30; pfam04012 1052585009920 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052585009921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585009922 putative substrate translocation pore; other site 1052585009923 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 1052585009924 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052585009925 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052585009926 Walker A/P-loop; other site 1052585009927 ATP binding site [chemical binding]; other site 1052585009928 Q-loop/lid; other site 1052585009929 ABC transporter signature motif; other site 1052585009930 Walker B; other site 1052585009931 D-loop; other site 1052585009932 H-loop/switch region; other site 1052585009933 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 1052585009934 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052585009935 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585009936 ABC-ATPase subunit interface; other site 1052585009937 dimer interface [polypeptide binding]; other site 1052585009938 putative PBP binding regions; other site 1052585009939 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052585009940 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1052585009941 putative binding site residues; other site 1052585009942 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1052585009943 classical (c) SDRs; Region: SDR_c; cd05233 1052585009944 NAD(P) binding site [chemical binding]; other site 1052585009945 active site 1052585009946 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1052585009947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585009948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585009949 dimer interface [polypeptide binding]; other site 1052585009950 phosphorylation site [posttranslational modification] 1052585009951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585009952 ATP binding site [chemical binding]; other site 1052585009953 Mg2+ binding site [ion binding]; other site 1052585009954 G-X-G motif; other site 1052585009955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585009956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585009957 active site 1052585009958 phosphorylation site [posttranslational modification] 1052585009959 intermolecular recognition site; other site 1052585009960 dimerization interface [polypeptide binding]; other site 1052585009961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585009962 DNA binding site [nucleotide binding] 1052585009963 hypothetical protein; Provisional; Region: PRK14082 1052585009964 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1052585009965 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585009966 DNA binding residues [nucleotide binding] 1052585009967 YvrJ protein family; Region: YvrJ; pfam12841 1052585009968 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1052585009969 Cupin; Region: Cupin_1; smart00835 1052585009970 Cupin; Region: Cupin_1; smart00835 1052585009971 Regulatory protein YrvL; Region: YrvL; pfam14184 1052585009972 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052585009973 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052585009974 FtsX-like permease family; Region: FtsX; pfam02687 1052585009975 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585009976 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052585009977 Walker A/P-loop; other site 1052585009978 ATP binding site [chemical binding]; other site 1052585009979 Q-loop/lid; other site 1052585009980 ABC transporter signature motif; other site 1052585009981 Walker B; other site 1052585009982 D-loop; other site 1052585009983 H-loop/switch region; other site 1052585009984 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1052585009985 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1052585009986 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052585009987 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052585009988 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052585009989 Walker A/P-loop; other site 1052585009990 ATP binding site [chemical binding]; other site 1052585009991 Q-loop/lid; other site 1052585009992 ABC transporter signature motif; other site 1052585009993 Walker B; other site 1052585009994 D-loop; other site 1052585009995 H-loop/switch region; other site 1052585009996 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052585009997 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585009998 ABC-ATPase subunit interface; other site 1052585009999 dimer interface [polypeptide binding]; other site 1052585010000 putative PBP binding regions; other site 1052585010001 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052585010002 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585010003 ABC-ATPase subunit interface; other site 1052585010004 dimer interface [polypeptide binding]; other site 1052585010005 putative PBP binding regions; other site 1052585010006 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052585010007 putative ligand binding residues [chemical binding]; other site 1052585010008 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052585010009 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1052585010010 Spore germination protein; Region: Spore_permease; cl17796 1052585010011 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; cl09798 1052585010012 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1052585010013 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052585010014 Sulfatase; Region: Sulfatase; pfam00884 1052585010015 DNA binding domain, excisionase family; Region: excise; TIGR01764 1052585010016 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 1052585010017 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1052585010018 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1052585010019 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1052585010020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585010021 dimer interface [polypeptide binding]; other site 1052585010022 conserved gate region; other site 1052585010023 putative PBP binding loops; other site 1052585010024 ABC-ATPase subunit interface; other site 1052585010025 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052585010026 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585010027 active site 1052585010028 catalytic tetrad [active] 1052585010029 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1052585010030 sulfite reductase subunit beta; Provisional; Region: PRK13504 1052585010031 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052585010032 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052585010033 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1052585010034 Flavodoxin; Region: Flavodoxin_1; pfam00258 1052585010035 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1052585010036 FAD binding pocket [chemical binding]; other site 1052585010037 FAD binding motif [chemical binding]; other site 1052585010038 catalytic residues [active] 1052585010039 NAD binding pocket [chemical binding]; other site 1052585010040 phosphate binding motif [ion binding]; other site 1052585010041 beta-alpha-beta structure motif; other site 1052585010042 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1052585010043 Part of AAA domain; Region: AAA_19; pfam13245 1052585010044 Family description; Region: UvrD_C_2; pfam13538 1052585010045 Predicted membrane protein [Function unknown]; Region: COG2860 1052585010046 UPF0126 domain; Region: UPF0126; pfam03458 1052585010047 UPF0126 domain; Region: UPF0126; pfam03458 1052585010048 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1052585010049 Thioredoxin; Region: Thioredoxin_4; pfam13462 1052585010050 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1052585010051 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052585010052 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585010053 metal-binding site [ion binding] 1052585010054 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052585010055 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1052585010056 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052585010057 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585010058 metal-binding site [ion binding] 1052585010059 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052585010060 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585010061 metal-binding site [ion binding] 1052585010062 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052585010063 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1052585010064 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052585010065 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585010066 metal-binding site [ion binding] 1052585010067 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 1052585010068 putative homodimer interface [polypeptide binding]; other site 1052585010069 putative homotetramer interface [polypeptide binding]; other site 1052585010070 allosteric switch controlling residues; other site 1052585010071 putative metal binding site [ion binding]; other site 1052585010072 putative homodimer-homodimer interface [polypeptide binding]; other site 1052585010073 putative oxidoreductase; Provisional; Region: PRK11579 1052585010074 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052585010075 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052585010076 azoreductase; Reviewed; Region: PRK00170 1052585010077 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052585010078 Predicted membrane protein [Function unknown]; Region: COG1289 1052585010079 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1052585010080 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1052585010081 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1052585010082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585010083 DNA-binding site [nucleotide binding]; DNA binding site 1052585010084 FCD domain; Region: FCD; pfam07729 1052585010085 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052585010086 EamA-like transporter family; Region: EamA; pfam00892 1052585010087 EamA-like transporter family; Region: EamA; pfam00892 1052585010088 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052585010089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585010090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585010091 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052585010092 classical (c) SDRs; Region: SDR_c; cd05233 1052585010093 NAD(P) binding site [chemical binding]; other site 1052585010094 active site 1052585010095 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1052585010096 SmpB-tmRNA interface; other site 1052585010097 ribonuclease R; Region: RNase_R; TIGR02063 1052585010098 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1052585010099 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052585010100 RNB domain; Region: RNB; pfam00773 1052585010101 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1052585010102 RNA binding site [nucleotide binding]; other site 1052585010103 Esterase/lipase [General function prediction only]; Region: COG1647 1052585010104 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052585010105 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052585010106 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1052585010107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585010108 salt bridge; other site 1052585010109 non-specific DNA binding site [nucleotide binding]; other site 1052585010110 sequence-specific DNA binding site [nucleotide binding]; other site 1052585010111 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052585010112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585010113 non-specific DNA binding site [nucleotide binding]; other site 1052585010114 salt bridge; other site 1052585010115 sequence-specific DNA binding site [nucleotide binding]; other site 1052585010116 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052585010117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585010118 non-specific DNA binding site [nucleotide binding]; other site 1052585010119 salt bridge; other site 1052585010120 sequence-specific DNA binding site [nucleotide binding]; other site 1052585010121 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052585010122 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052585010123 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1052585010124 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585010125 dimerization interface [polypeptide binding]; other site 1052585010126 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585010127 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585010128 dimer interface [polypeptide binding]; other site 1052585010129 putative CheW interface [polypeptide binding]; other site 1052585010130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585010131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585010132 dimer interface [polypeptide binding]; other site 1052585010133 phosphorylation site [posttranslational modification] 1052585010134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585010135 ATP binding site [chemical binding]; other site 1052585010136 Mg2+ binding site [ion binding]; other site 1052585010137 G-X-G motif; other site 1052585010138 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585010139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585010140 active site 1052585010141 phosphorylation site [posttranslational modification] 1052585010142 intermolecular recognition site; other site 1052585010143 dimerization interface [polypeptide binding]; other site 1052585010144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585010145 DNA binding site [nucleotide binding] 1052585010146 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1052585010147 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052585010148 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1052585010149 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052585010150 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1052585010151 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1052585010152 Walker A/P-loop; other site 1052585010153 ATP binding site [chemical binding]; other site 1052585010154 Q-loop/lid; other site 1052585010155 ABC transporter signature motif; other site 1052585010156 Walker B; other site 1052585010157 D-loop; other site 1052585010158 H-loop/switch region; other site 1052585010159 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1052585010160 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 1052585010161 active site 1052585010162 zinc binding site [ion binding]; other site 1052585010163 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585010164 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1052585010165 Walker A/P-loop; other site 1052585010166 ATP binding site [chemical binding]; other site 1052585010167 Q-loop/lid; other site 1052585010168 ABC transporter signature motif; other site 1052585010169 Walker B; other site 1052585010170 D-loop; other site 1052585010171 H-loop/switch region; other site 1052585010172 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1052585010173 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1052585010174 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 1052585010175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585010176 dimer interface [polypeptide binding]; other site 1052585010177 conserved gate region; other site 1052585010178 putative PBP binding loops; other site 1052585010179 ABC-ATPase subunit interface; other site 1052585010180 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1052585010181 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1052585010182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585010183 dimer interface [polypeptide binding]; other site 1052585010184 conserved gate region; other site 1052585010185 putative PBP binding loops; other site 1052585010186 ABC-ATPase subunit interface; other site 1052585010187 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1052585010188 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1052585010189 Walker A/P-loop; other site 1052585010190 ATP binding site [chemical binding]; other site 1052585010191 Q-loop/lid; other site 1052585010192 ABC transporter signature motif; other site 1052585010193 Walker B; other site 1052585010194 D-loop; other site 1052585010195 H-loop/switch region; other site 1052585010196 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1052585010197 Predicted transcriptional regulators [Transcription]; Region: COG1510 1052585010198 MarR family; Region: MarR_2; pfam12802 1052585010199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585010200 dimer interface [polypeptide binding]; other site 1052585010201 conserved gate region; other site 1052585010202 putative PBP binding loops; other site 1052585010203 ABC-ATPase subunit interface; other site 1052585010204 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1052585010205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585010206 dimer interface [polypeptide binding]; other site 1052585010207 conserved gate region; other site 1052585010208 putative PBP binding loops; other site 1052585010209 ABC-ATPase subunit interface; other site 1052585010210 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1052585010211 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1052585010212 Walker A/P-loop; other site 1052585010213 ATP binding site [chemical binding]; other site 1052585010214 Q-loop/lid; other site 1052585010215 ABC transporter signature motif; other site 1052585010216 Walker B; other site 1052585010217 D-loop; other site 1052585010218 H-loop/switch region; other site 1052585010219 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1052585010220 Predicted transcriptional regulators [Transcription]; Region: COG1510 1052585010221 MarR family; Region: MarR_2; pfam12802 1052585010222 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1052585010223 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1052585010224 Double zinc ribbon; Region: DZR; pfam12773 1052585010225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1052585010226 Predicted membrane protein [Function unknown]; Region: COG4640 1052585010227 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1052585010228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585010229 Coenzyme A binding pocket [chemical binding]; other site 1052585010230 enolase; Provisional; Region: eno; PRK00077 1052585010231 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1052585010232 dimer interface [polypeptide binding]; other site 1052585010233 metal binding site [ion binding]; metal-binding site 1052585010234 substrate binding pocket [chemical binding]; other site 1052585010235 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1052585010236 phosphoglyceromutase; Provisional; Region: PRK05434 1052585010237 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1052585010238 triosephosphate isomerase; Provisional; Region: PRK14565 1052585010239 substrate binding site [chemical binding]; other site 1052585010240 dimer interface [polypeptide binding]; other site 1052585010241 catalytic triad [active] 1052585010242 Phosphoglycerate kinase; Region: PGK; pfam00162 1052585010243 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1052585010244 substrate binding site [chemical binding]; other site 1052585010245 hinge regions; other site 1052585010246 ADP binding site [chemical binding]; other site 1052585010247 catalytic site [active] 1052585010248 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1052585010249 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1052585010250 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1052585010251 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1052585010252 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1052585010253 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1052585010254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585010255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585010256 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052585010257 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585010258 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1052585010259 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1052585010260 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585010261 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585010262 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585010263 dimerization interface [polypeptide binding]; other site 1052585010264 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1052585010265 EamA-like transporter family; Region: EamA; pfam00892 1052585010266 EamA-like transporter family; Region: EamA; pfam00892 1052585010267 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052585010268 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1052585010269 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1052585010270 active site 1052585010271 Homeodomain-like domain; Region: HTH_23; pfam13384 1052585010272 putative transposase OrfB; Reviewed; Region: PHA02517 1052585010273 HTH-like domain; Region: HTH_21; pfam13276 1052585010274 Integrase core domain; Region: rve; pfam00665 1052585010275 Integrase core domain; Region: rve_3; pfam13683 1052585010276 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1052585010277 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1052585010278 iron-sulfur cluster-binding protein; Region: TIGR00273 1052585010279 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1052585010280 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1052585010281 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1052585010282 Cysteine-rich domain; Region: CCG; pfam02754 1052585010283 Cysteine-rich domain; Region: CCG; pfam02754 1052585010284 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1052585010285 Predicted transcriptional regulators [Transcription]; Region: COG1695 1052585010286 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1052585010287 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585010288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585010289 active site 1052585010290 phosphorylation site [posttranslational modification] 1052585010291 intermolecular recognition site; other site 1052585010292 dimerization interface [polypeptide binding]; other site 1052585010293 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585010294 DNA binding residues [nucleotide binding] 1052585010295 dimerization interface [polypeptide binding]; other site 1052585010296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585010297 Histidine kinase; Region: HisKA_3; pfam07730 1052585010298 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1052585010299 ATP binding site [chemical binding]; other site 1052585010300 Mg2+ binding site [ion binding]; other site 1052585010301 G-X-G motif; other site 1052585010302 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1052585010303 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1052585010304 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585010305 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052585010306 Walker A/P-loop; other site 1052585010307 ATP binding site [chemical binding]; other site 1052585010308 Q-loop/lid; other site 1052585010309 ABC transporter signature motif; other site 1052585010310 Walker B; other site 1052585010311 D-loop; other site 1052585010312 H-loop/switch region; other site 1052585010313 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585010314 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1052585010315 catalytic site [active] 1052585010316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585010317 PAS domain; Region: PAS_9; pfam13426 1052585010318 putative active site [active] 1052585010319 heme pocket [chemical binding]; other site 1052585010320 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1052585010321 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1052585010322 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 1052585010323 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1052585010324 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1052585010325 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1052585010326 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1052585010327 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585010328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585010329 dimer interface [polypeptide binding]; other site 1052585010330 conserved gate region; other site 1052585010331 putative PBP binding loops; other site 1052585010332 ABC-ATPase subunit interface; other site 1052585010333 TM2 domain; Region: TM2; pfam05154 1052585010334 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052585010335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585010336 dimer interface [polypeptide binding]; other site 1052585010337 conserved gate region; other site 1052585010338 ABC-ATPase subunit interface; other site 1052585010339 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1052585010340 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052585010341 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585010342 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585010343 DNA binding site [nucleotide binding] 1052585010344 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1052585010345 putative dimerization interface [polypeptide binding]; other site 1052585010346 putative ligand binding site [chemical binding]; other site 1052585010347 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1052585010348 L-lactate permease; Region: Lactate_perm; pfam02652 1052585010349 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1052585010350 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1052585010351 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1052585010352 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1052585010353 YvfG protein; Region: YvfG; pfam09628 1052585010354 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1052585010355 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1052585010356 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1052585010357 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1052585010358 inhibitor-cofactor binding pocket; inhibition site 1052585010359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585010360 catalytic residue [active] 1052585010361 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1052585010362 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1052585010363 putative trimer interface [polypeptide binding]; other site 1052585010364 putative CoA binding site [chemical binding]; other site 1052585010365 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1052585010366 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1052585010367 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052585010368 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585010369 active site 1052585010370 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1052585010371 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1052585010372 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585010373 active site 1052585010374 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585010375 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1052585010376 putative ADP-binding pocket [chemical binding]; other site 1052585010377 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052585010378 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1052585010379 active site 1052585010380 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1052585010381 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585010382 putative ADP-binding pocket [chemical binding]; other site 1052585010383 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1052585010384 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1052585010385 NAD(P) binding site [chemical binding]; other site 1052585010386 homodimer interface [polypeptide binding]; other site 1052585010387 substrate binding site [chemical binding]; other site 1052585010388 active site 1052585010389 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1052585010390 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1052585010391 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1052585010392 Chain length determinant protein; Region: Wzz; cl15801 1052585010393 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052585010394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585010395 non-specific DNA binding site [nucleotide binding]; other site 1052585010396 salt bridge; other site 1052585010397 sequence-specific DNA binding site [nucleotide binding]; other site 1052585010398 Anti-repressor SinI; Region: SinI; pfam08671 1052585010399 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1052585010400 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1052585010401 substrate binding pocket [chemical binding]; other site 1052585010402 catalytic triad [active] 1052585010403 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1052585010404 hypothetical protein; Provisional; Region: PRK00872 1052585010405 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1052585010406 aspartate racemase; Region: asp_race; TIGR00035 1052585010407 Beta-lactamase; Region: Beta-lactamase; pfam00144 1052585010408 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052585010409 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1052585010410 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1052585010411 active site 1052585010412 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1052585010413 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052585010414 substrate binding [chemical binding]; other site 1052585010415 active site 1052585010416 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052585010417 amino acid transporter; Region: 2A0306; TIGR00909 1052585010418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585010419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585010420 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052585010421 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052585010422 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1052585010423 Clp protease; Region: CLP_protease; pfam00574 1052585010424 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1052585010425 oligomer interface [polypeptide binding]; other site 1052585010426 active site residues [active] 1052585010427 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1052585010428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585010429 motif II; other site 1052585010430 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052585010431 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052585010432 Ca binding site [ion binding]; other site 1052585010433 active site 1052585010434 catalytic site [active] 1052585010435 maltose phosphorylase; Provisional; Region: PRK13807 1052585010436 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1052585010437 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1052585010438 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1052585010439 Predicted integral membrane protein [Function unknown]; Region: COG5521 1052585010440 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585010441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585010442 dimer interface [polypeptide binding]; other site 1052585010443 conserved gate region; other site 1052585010444 ABC-ATPase subunit interface; other site 1052585010445 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1052585010446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585010447 dimer interface [polypeptide binding]; other site 1052585010448 conserved gate region; other site 1052585010449 putative PBP binding loops; other site 1052585010450 ABC-ATPase subunit interface; other site 1052585010451 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1052585010452 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052585010453 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1052585010454 homodimer interface [polypeptide binding]; other site 1052585010455 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1052585010456 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1052585010457 active site 1052585010458 homodimer interface [polypeptide binding]; other site 1052585010459 catalytic site [active] 1052585010460 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585010461 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585010462 DNA binding site [nucleotide binding] 1052585010463 domain linker motif; other site 1052585010464 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052585010465 ligand binding site [chemical binding]; other site 1052585010466 dimerization interface [polypeptide binding]; other site 1052585010467 TIGR00730 family protein; Region: TIGR00730 1052585010468 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1052585010469 metal binding site [ion binding]; metal-binding site 1052585010470 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1052585010471 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1052585010472 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1052585010473 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1052585010474 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1052585010475 active site clefts [active] 1052585010476 zinc binding site [ion binding]; other site 1052585010477 dimer interface [polypeptide binding]; other site 1052585010478 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1052585010479 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1052585010480 dimerization interface [polypeptide binding]; other site 1052585010481 ligand binding site [chemical binding]; other site 1052585010482 NADP binding site [chemical binding]; other site 1052585010483 catalytic site [active] 1052585010484 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052585010485 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585010486 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052585010487 Walker A/P-loop; other site 1052585010488 ATP binding site [chemical binding]; other site 1052585010489 Q-loop/lid; other site 1052585010490 ABC transporter signature motif; other site 1052585010491 Walker B; other site 1052585010492 D-loop; other site 1052585010493 H-loop/switch region; other site 1052585010494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585010495 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1052585010496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585010497 ATP binding site [chemical binding]; other site 1052585010498 Mg2+ binding site [ion binding]; other site 1052585010499 G-X-G motif; other site 1052585010500 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585010501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585010502 active site 1052585010503 phosphorylation site [posttranslational modification] 1052585010504 intermolecular recognition site; other site 1052585010505 dimerization interface [polypeptide binding]; other site 1052585010506 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585010507 DNA binding site [nucleotide binding] 1052585010508 Lysis protein; Region: Lysis_col; pfam02402 1052585010509 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1052585010510 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052585010511 dimerization domain swap beta strand [polypeptide binding]; other site 1052585010512 regulatory protein interface [polypeptide binding]; other site 1052585010513 active site 1052585010514 regulatory phosphorylation site [posttranslational modification]; other site 1052585010515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1052585010516 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1052585010517 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1052585010518 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1052585010519 phosphate binding site [ion binding]; other site 1052585010520 putative substrate binding pocket [chemical binding]; other site 1052585010521 dimer interface [polypeptide binding]; other site 1052585010522 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1052585010523 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1052585010524 putative active site [active] 1052585010525 nucleotide binding site [chemical binding]; other site 1052585010526 nudix motif; other site 1052585010527 putative metal binding site [ion binding]; other site 1052585010528 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1052585010529 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052585010530 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585010531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1052585010532 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052585010533 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052585010534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585010535 binding surface 1052585010536 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585010537 TPR motif; other site 1052585010538 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585010539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585010540 TPR motif; other site 1052585010541 binding surface 1052585010542 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585010543 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052585010544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585010545 Walker A/P-loop; other site 1052585010546 ATP binding site [chemical binding]; other site 1052585010547 Q-loop/lid; other site 1052585010548 ABC transporter signature motif; other site 1052585010549 Walker B; other site 1052585010550 D-loop; other site 1052585010551 H-loop/switch region; other site 1052585010552 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1052585010553 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1052585010554 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1052585010555 metal binding site [ion binding]; metal-binding site 1052585010556 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1052585010557 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1052585010558 substrate binding site [chemical binding]; other site 1052585010559 glutamase interaction surface [polypeptide binding]; other site 1052585010560 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1052585010561 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1052585010562 catalytic residues [active] 1052585010563 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1052585010564 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1052585010565 putative active site [active] 1052585010566 oxyanion strand; other site 1052585010567 catalytic triad [active] 1052585010568 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1052585010569 putative active site pocket [active] 1052585010570 4-fold oligomerization interface [polypeptide binding]; other site 1052585010571 metal binding residues [ion binding]; metal-binding site 1052585010572 3-fold/trimer interface [polypeptide binding]; other site 1052585010573 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1052585010574 histidinol dehydrogenase; Region: hisD; TIGR00069 1052585010575 NAD binding site [chemical binding]; other site 1052585010576 dimerization interface [polypeptide binding]; other site 1052585010577 product binding site; other site 1052585010578 substrate binding site [chemical binding]; other site 1052585010579 zinc binding site [ion binding]; other site 1052585010580 catalytic residues [active] 1052585010581 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1052585010582 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1052585010583 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1052585010584 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1052585010585 dimer interface [polypeptide binding]; other site 1052585010586 motif 1; other site 1052585010587 active site 1052585010588 motif 2; other site 1052585010589 motif 3; other site 1052585010590 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1052585010591 putative active site [active] 1052585010592 Pectate lyase; Region: Pectate_lyase; pfam03211 1052585010593 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1052585010594 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1052585010595 CoA binding site [chemical binding]; other site 1052585010596 active site 1052585010597 pyrophosphatase PpaX; Provisional; Region: PRK13288 1052585010598 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585010599 motif II; other site 1052585010600 Nucleoside recognition; Region: Gate; pfam07670 1052585010601 Nucleoside recognition; Region: Gate; pfam07670 1052585010602 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1052585010603 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1052585010604 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1052585010605 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1052585010606 Hpr binding site; other site 1052585010607 active site 1052585010608 homohexamer subunit interaction site [polypeptide binding]; other site 1052585010609 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1052585010610 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1052585010611 active site 1052585010612 dimer interface [polypeptide binding]; other site 1052585010613 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1052585010614 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1052585010615 active site 1052585010616 trimer interface [polypeptide binding]; other site 1052585010617 allosteric site; other site 1052585010618 active site lid [active] 1052585010619 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052585010620 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052585010621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585010622 DNA-binding site [nucleotide binding]; DNA binding site 1052585010623 UTRA domain; Region: UTRA; pfam07702 1052585010624 Lamin Tail Domain; Region: LTD; pfam00932 1052585010625 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1052585010626 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1052585010627 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052585010628 putative active site [active] 1052585010629 putative metal binding site [ion binding]; other site 1052585010630 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585010631 MarR family; Region: MarR; pfam01047 1052585010632 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052585010633 Cytochrome P450; Region: p450; cl12078 1052585010634 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585010635 MarR family; Region: MarR; pfam01047 1052585010636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585010637 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585010638 putative substrate translocation pore; other site 1052585010639 Predicted membrane protein [Function unknown]; Region: COG1950 1052585010640 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1052585010641 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1052585010642 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052585010643 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1052585010644 flagellin; Provisional; Region: PRK12804 1052585010645 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1052585010646 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052585010647 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1052585010648 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1052585010649 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1052585010650 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1052585010651 excinuclease ABC subunit B; Provisional; Region: PRK05298 1052585010652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585010653 ATP binding site [chemical binding]; other site 1052585010654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585010655 nucleotide binding region [chemical binding]; other site 1052585010656 ATP-binding site [chemical binding]; other site 1052585010657 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1052585010658 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1052585010659 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 1052585010660 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1052585010661 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1052585010662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585010663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585010664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585010665 putative substrate translocation pore; other site 1052585010666 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1052585010667 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052585010668 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1052585010669 C-terminal peptidase (prc); Region: prc; TIGR00225 1052585010670 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1052585010671 protein binding site [polypeptide binding]; other site 1052585010672 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1052585010673 Catalytic dyad [active] 1052585010674 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052585010675 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1052585010676 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1052585010677 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1052585010678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585010679 Walker A/P-loop; other site 1052585010680 ATP binding site [chemical binding]; other site 1052585010681 Q-loop/lid; other site 1052585010682 ABC transporter signature motif; other site 1052585010683 Walker B; other site 1052585010684 D-loop; other site 1052585010685 H-loop/switch region; other site 1052585010686 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1052585010687 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1052585010688 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585010689 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585010690 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585010691 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052585010692 putative transposase OrfB; Reviewed; Region: PHA02517 1052585010693 HTH-like domain; Region: HTH_21; pfam13276 1052585010694 Integrase core domain; Region: rve; pfam00665 1052585010695 Integrase core domain; Region: rve_3; pfam13683 1052585010696 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1052585010697 peptide chain release factor 2; Provisional; Region: PRK06746 1052585010698 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1052585010699 RF-1 domain; Region: RF-1; pfam00472 1052585010700 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1052585010701 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1052585010702 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1052585010703 nucleotide binding region [chemical binding]; other site 1052585010704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1052585010705 ATP-binding site [chemical binding]; other site 1052585010706 SEC-C motif; Region: SEC-C; pfam02810 1052585010707 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1052585010708 30S subunit binding site; other site 1052585010709 Flagellar protein FliT; Region: FliT; pfam05400 1052585010710 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 1052585010711 flagellar capping protein; Validated; Region: fliD; PRK07737 1052585010712 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1052585010713 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1052585010714 FlaG protein; Region: FlaG; cl00591 1052585010715 flagellin; Provisional; Region: PRK12804 1052585010716 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1052585010717 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052585010718 carbon storage regulator; Provisional; Region: PRK01712 1052585010719 flagellar assembly protein FliW; Provisional; Region: PRK13285 1052585010720 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1052585010721 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1052585010722 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052585010723 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1052585010724 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1052585010725 FlgN protein; Region: FlgN; pfam05130 1052585010726 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 1052585010727 flagellar operon protein TIGR03826; Region: YvyF 1052585010728 comF family protein; Region: comF; TIGR00201 1052585010729 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585010730 active site 1052585010731 Late competence development protein ComFB; Region: ComFB; pfam10719 1052585010732 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1052585010733 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585010734 ATP binding site [chemical binding]; other site 1052585010735 putative Mg++ binding site [ion binding]; other site 1052585010736 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585010737 nucleotide binding region [chemical binding]; other site 1052585010738 ATP-binding site [chemical binding]; other site 1052585010739 EDD domain protein, DegV family; Region: DegV; TIGR00762 1052585010740 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1052585010741 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585010742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585010743 active site 1052585010744 phosphorylation site [posttranslational modification] 1052585010745 intermolecular recognition site; other site 1052585010746 dimerization interface [polypeptide binding]; other site 1052585010747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585010748 DNA binding residues [nucleotide binding] 1052585010749 dimerization interface [polypeptide binding]; other site 1052585010750 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585010751 Histidine kinase; Region: HisKA_3; pfam07730 1052585010752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585010753 ATP binding site [chemical binding]; other site 1052585010754 Mg2+ binding site [ion binding]; other site 1052585010755 G-X-G motif; other site 1052585010756 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1052585010757 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1052585010758 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1052585010759 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1052585010760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585010761 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1052585010762 Walker A/P-loop; other site 1052585010763 ATP binding site [chemical binding]; other site 1052585010764 Q-loop/lid; other site 1052585010765 ABC transporter signature motif; other site 1052585010766 Walker B; other site 1052585010767 D-loop; other site 1052585010768 H-loop/switch region; other site 1052585010769 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1052585010770 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1052585010771 Mg++ binding site [ion binding]; other site 1052585010772 putative catalytic motif [active] 1052585010773 substrate binding site [chemical binding]; other site 1052585010774 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1052585010775 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585010776 putative homodimer interface [polypeptide binding]; other site 1052585010777 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052585010778 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585010779 active site 1052585010780 Chain length determinant protein; Region: Wzz; cl15801 1052585010781 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1052585010782 O-Antigen ligase; Region: Wzy_C; pfam04932 1052585010783 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1052585010784 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1052585010785 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052585010786 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1052585010787 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585010788 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1052585010789 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052585010790 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1052585010791 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1052585010792 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1052585010793 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052585010794 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585010795 active site 1052585010796 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1052585010797 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052585010798 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052585010799 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052585010800 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1052585010801 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052585010802 active site 1052585010803 metal binding site [ion binding]; metal-binding site 1052585010804 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052585010805 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1052585010806 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052585010807 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052585010808 Stage II sporulation protein; Region: SpoIID; pfam08486 1052585010809 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1052585010810 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1052585010811 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1052585010812 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1052585010813 active site 1052585010814 homodimer interface [polypeptide binding]; other site 1052585010815 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052585010816 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585010817 active site 1052585010818 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1052585010819 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052585010820 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585010821 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052585010822 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052585010823 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1052585010824 active site 1052585010825 tetramer interface; other site 1052585010826 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1052585010827 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1052585010828 Walker A/P-loop; other site 1052585010829 ATP binding site [chemical binding]; other site 1052585010830 Q-loop/lid; other site 1052585010831 ABC transporter signature motif; other site 1052585010832 Walker B; other site 1052585010833 D-loop; other site 1052585010834 H-loop/switch region; other site 1052585010835 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1052585010836 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1052585010837 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585010838 active site 1052585010839 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1052585010840 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052585010841 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1052585010842 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052585010843 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1052585010844 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1052585010845 active site 1052585010846 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1052585010847 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1052585010848 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1052585010849 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052585010850 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1052585010851 substrate binding site; other site 1052585010852 dimer interface; other site 1052585010853 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1052585010854 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052585010855 putative NAD(P) binding site [chemical binding]; other site 1052585010856 putative catalytic Zn binding site [ion binding]; other site 1052585010857 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1052585010858 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052585010859 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1052585010860 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052585010861 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1052585010862 Bacterial SH3 domain; Region: SH3_3; pfam08239 1052585010863 Lysozyme subfamily 2; Region: LYZ2; smart00047 1052585010864 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1052585010865 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1052585010866 Spore germination protein; Region: Spore_permease; pfam03845 1052585010867 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052585010868 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052585010869 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052585010870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585010871 putative substrate translocation pore; other site 1052585010872 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1052585010873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585010874 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052585010875 active site 1052585010876 motif I; other site 1052585010877 motif II; other site 1052585010878 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1052585010879 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052585010880 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052585010881 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052585010882 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052585010883 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052585010884 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052585010885 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1052585010886 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1052585010887 putative active site [active] 1052585010888 putative metal binding site [ion binding]; other site 1052585010889 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1052585010890 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1052585010891 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052585010892 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585010893 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585010894 DNA binding site [nucleotide binding] 1052585010895 domain linker motif; other site 1052585010896 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052585010897 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052585010898 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1052585010899 substrate binding site [chemical binding]; other site 1052585010900 dimer interface [polypeptide binding]; other site 1052585010901 ATP binding site [chemical binding]; other site 1052585010902 D-ribose pyranase; Provisional; Region: PRK11797 1052585010903 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1052585010904 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1052585010905 Walker A/P-loop; other site 1052585010906 ATP binding site [chemical binding]; other site 1052585010907 Q-loop/lid; other site 1052585010908 ABC transporter signature motif; other site 1052585010909 Walker B; other site 1052585010910 D-loop; other site 1052585010911 H-loop/switch region; other site 1052585010912 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1052585010913 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1052585010914 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1052585010915 TM-ABC transporter signature motif; other site 1052585010916 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1052585010917 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1052585010918 ligand binding site [chemical binding]; other site 1052585010919 dimerization interface [polypeptide binding]; other site 1052585010920 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1052585010921 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1052585010922 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1052585010923 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1052585010924 acetolactate synthase; Reviewed; Region: PRK08617 1052585010925 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052585010926 PYR/PP interface [polypeptide binding]; other site 1052585010927 dimer interface [polypeptide binding]; other site 1052585010928 TPP binding site [chemical binding]; other site 1052585010929 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1052585010930 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1052585010931 TPP-binding site [chemical binding]; other site 1052585010932 dimer interface [polypeptide binding]; other site 1052585010933 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1052585010934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585010935 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1052585010936 putative dimerization interface [polypeptide binding]; other site 1052585010937 putative substrate binding pocket [chemical binding]; other site 1052585010938 CotH protein; Region: CotH; pfam08757 1052585010939 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1052585010940 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1052585010941 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1052585010942 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1052585010943 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052585010944 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585010945 putative DNA binding site [nucleotide binding]; other site 1052585010946 putative Zn2+ binding site [ion binding]; other site 1052585010947 AsnC family; Region: AsnC_trans_reg; pfam01037 1052585010948 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1052585010949 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1052585010950 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1052585010951 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052585010952 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585010953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585010954 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585010955 dimerization interface [polypeptide binding]; other site 1052585010956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1052585010957 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1052585010958 Cupin domain; Region: Cupin_2; cl17218 1052585010959 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052585010960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585010961 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1052585010962 Active_site [active] 1052585010963 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 1052585010964 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052585010965 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1052585010966 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1052585010967 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1052585010968 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052585010969 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1052585010970 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1052585010971 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1052585010972 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1052585010973 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1052585010974 Chain length determinant protein; Region: Wzz; cl15801 1052585010975 SWIM zinc finger; Region: SWIM; pfam04434 1052585010976 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1052585010977 SNF2 Helicase protein; Region: DUF3670; pfam12419 1052585010978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585010979 ATP binding site [chemical binding]; other site 1052585010980 putative Mg++ binding site [ion binding]; other site 1052585010981 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585010982 nucleotide binding region [chemical binding]; other site 1052585010983 ATP-binding site [chemical binding]; other site 1052585010984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585010985 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052585010986 active site 1052585010987 motif I; other site 1052585010988 motif II; other site 1052585010989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585010990 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052585010991 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1052585010992 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1052585010993 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1052585010994 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1052585010995 dimer interface [polypeptide binding]; other site 1052585010996 ssDNA binding site [nucleotide binding]; other site 1052585010997 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585010998 YwpF-like protein; Region: YwpF; pfam14183 1052585010999 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1052585011000 active site 1052585011001 catalytic site [active] 1052585011002 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1052585011003 Collagen binding domain; Region: Collagen_bind; pfam05737 1052585011004 Collagen binding domain; Region: Collagen_bind; pfam05737 1052585011005 Collagen binding domain; Region: Collagen_bind; pfam05737 1052585011006 Collagen binding domain; Region: Collagen_bind; pfam05737 1052585011007 Cna protein B-type domain; Region: Cna_B; pfam05738 1052585011008 Cna protein B-type domain; Region: Cna_B; pfam05738 1052585011009 Cna protein B-type domain; Region: Cna_B; pfam05738 1052585011010 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1052585011011 Cna protein B-type domain; Region: Cna_B; pfam05738 1052585011012 Cna protein B-type domain; Region: Cna_B; pfam05738 1052585011013 Cna protein B-type domain; Region: Cna_B; pfam05738 1052585011014 Cna protein B-type domain; Region: Cna_B; pfam05738 1052585011015 Cna protein B-type domain; Region: Cna_B; pfam05738 1052585011016 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1052585011017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585011018 active site 1052585011019 phosphorylation site [posttranslational modification] 1052585011020 intermolecular recognition site; other site 1052585011021 dimerization interface [polypeptide binding]; other site 1052585011022 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1052585011023 DNA binding site [nucleotide binding] 1052585011024 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1052585011025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585011026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585011027 dimer interface [polypeptide binding]; other site 1052585011028 phosphorylation site [posttranslational modification] 1052585011029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585011030 ATP binding site [chemical binding]; other site 1052585011031 Mg2+ binding site [ion binding]; other site 1052585011032 G-X-G motif; other site 1052585011033 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1052585011034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585011035 active site 1052585011036 phosphorylation site [posttranslational modification] 1052585011037 intermolecular recognition site; other site 1052585011038 dimerization interface [polypeptide binding]; other site 1052585011039 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052585011040 Histidine kinase; Region: His_kinase; pfam06580 1052585011041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585011042 ATP binding site [chemical binding]; other site 1052585011043 Mg2+ binding site [ion binding]; other site 1052585011044 G-X-G motif; other site 1052585011045 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1052585011046 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1052585011047 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1052585011048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585011049 binding surface 1052585011050 TPR motif; other site 1052585011051 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585011052 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1052585011053 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1052585011054 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1052585011055 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1052585011056 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1052585011057 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1052585011058 MreB and similar proteins; Region: MreB_like; cd10225 1052585011059 nucleotide binding site [chemical binding]; other site 1052585011060 Mg binding site [ion binding]; other site 1052585011061 putative protofilament interaction site [polypeptide binding]; other site 1052585011062 RodZ interaction site [polypeptide binding]; other site 1052585011063 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1052585011064 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585011065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585011066 putative Zn2+ binding site [ion binding]; other site 1052585011067 putative DNA binding site [nucleotide binding]; other site 1052585011068 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585011069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011070 putative substrate translocation pore; other site 1052585011071 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1052585011072 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1052585011073 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1052585011074 Na binding site [ion binding]; other site 1052585011075 putative substrate binding site [chemical binding]; other site 1052585011076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011077 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585011078 putative substrate translocation pore; other site 1052585011079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011080 Isochorismatase family; Region: Isochorismatase; pfam00857 1052585011081 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1052585011082 catalytic triad [active] 1052585011083 conserved cis-peptide bond; other site 1052585011084 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1052585011085 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1052585011086 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1052585011087 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1052585011088 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1052585011089 active site 1052585011090 VanZ like family; Region: VanZ; pfam04892 1052585011091 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1052585011092 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052585011093 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052585011094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585011095 Coenzyme A binding pocket [chemical binding]; other site 1052585011096 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1052585011097 NeuB family; Region: NeuB; pfam03102 1052585011098 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1052585011099 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052585011100 active site 1052585011101 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1052585011102 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1052585011103 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052585011104 putative active site [active] 1052585011105 catalytic site [active] 1052585011106 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052585011107 putative active site [active] 1052585011108 catalytic site [active] 1052585011109 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1052585011110 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052585011111 DNA binding residues [nucleotide binding] 1052585011112 dimer interface [polypeptide binding]; other site 1052585011113 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1052585011114 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1052585011115 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052585011116 NAD binding site [chemical binding]; other site 1052585011117 substrate binding site [chemical binding]; other site 1052585011118 putative active site [active] 1052585011119 Predicted transcriptional regulator [Transcription]; Region: COG1959 1052585011120 Transcriptional regulator; Region: Rrf2; pfam02082 1052585011121 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1052585011122 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1052585011123 subunit interactions [polypeptide binding]; other site 1052585011124 active site 1052585011125 flap region; other site 1052585011126 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1052585011127 gamma-beta subunit interface [polypeptide binding]; other site 1052585011128 alpha-beta subunit interface [polypeptide binding]; other site 1052585011129 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1052585011130 alpha-gamma subunit interface [polypeptide binding]; other site 1052585011131 beta-gamma subunit interface [polypeptide binding]; other site 1052585011132 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1052585011133 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1052585011134 Walker A/P-loop; other site 1052585011135 ATP binding site [chemical binding]; other site 1052585011136 Q-loop/lid; other site 1052585011137 ABC transporter signature motif; other site 1052585011138 Walker B; other site 1052585011139 D-loop; other site 1052585011140 H-loop/switch region; other site 1052585011141 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1052585011142 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1052585011143 Walker A/P-loop; other site 1052585011144 ATP binding site [chemical binding]; other site 1052585011145 Q-loop/lid; other site 1052585011146 ABC transporter signature motif; other site 1052585011147 Walker B; other site 1052585011148 D-loop; other site 1052585011149 H-loop/switch region; other site 1052585011150 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1052585011151 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1052585011152 TM-ABC transporter signature motif; other site 1052585011153 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1052585011154 TM-ABC transporter signature motif; other site 1052585011155 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1052585011156 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1052585011157 putative ligand binding site [chemical binding]; other site 1052585011158 CsbD-like; Region: CsbD; pfam05532 1052585011159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585011160 binding surface 1052585011161 TPR motif; other site 1052585011162 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585011163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585011164 binding surface 1052585011165 TPR motif; other site 1052585011166 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1052585011167 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585011168 FeS/SAM binding site; other site 1052585011169 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1052585011170 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1052585011171 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1052585011172 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1052585011173 metal ion-dependent adhesion site (MIDAS); other site 1052585011174 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1052585011175 metal ion-dependent adhesion site (MIDAS); other site 1052585011176 stage II sporulation protein D; Region: spore_II_D; TIGR02870 1052585011177 Stage II sporulation protein; Region: SpoIID; pfam08486 1052585011178 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1052585011179 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1052585011180 hinge; other site 1052585011181 active site 1052585011182 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1052585011183 Predicted membrane protein [Function unknown]; Region: COG4836 1052585011184 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1052585011185 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1052585011186 gamma subunit interface [polypeptide binding]; other site 1052585011187 epsilon subunit interface [polypeptide binding]; other site 1052585011188 LBP interface [polypeptide binding]; other site 1052585011189 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1052585011190 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1052585011191 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1052585011192 alpha subunit interaction interface [polypeptide binding]; other site 1052585011193 Walker A motif; other site 1052585011194 ATP binding site [chemical binding]; other site 1052585011195 Walker B motif; other site 1052585011196 inhibitor binding site; inhibition site 1052585011197 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1052585011198 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1052585011199 core domain interface [polypeptide binding]; other site 1052585011200 delta subunit interface [polypeptide binding]; other site 1052585011201 epsilon subunit interface [polypeptide binding]; other site 1052585011202 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1052585011203 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1052585011204 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1052585011205 beta subunit interaction interface [polypeptide binding]; other site 1052585011206 Walker A motif; other site 1052585011207 ATP binding site [chemical binding]; other site 1052585011208 Walker B motif; other site 1052585011209 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1052585011210 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1052585011211 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1052585011212 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1052585011213 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1052585011214 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1052585011215 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1052585011216 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1052585011217 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1052585011218 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585011219 active site 1052585011220 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1052585011221 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1052585011222 dimer interface [polypeptide binding]; other site 1052585011223 active site 1052585011224 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1052585011225 folate binding site [chemical binding]; other site 1052585011226 hypothetical protein; Provisional; Region: PRK13690 1052585011227 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1052585011228 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052585011229 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1052585011230 active site 1052585011231 Predicted membrane protein [Function unknown]; Region: COG1971 1052585011232 Domain of unknown function DUF; Region: DUF204; pfam02659 1052585011233 Domain of unknown function DUF; Region: DUF204; pfam02659 1052585011234 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1052585011235 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1052585011236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052585011237 HemK family putative methylases; Region: hemK_fam; TIGR00536 1052585011238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585011239 S-adenosylmethionine binding site [chemical binding]; other site 1052585011240 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1052585011241 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1052585011242 RF-1 domain; Region: RF-1; pfam00472 1052585011243 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1052585011244 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585011245 putative metal binding site [ion binding]; other site 1052585011246 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1052585011247 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1052585011248 DNA binding residues [nucleotide binding] 1052585011249 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1052585011250 malate dehydrogenase; Provisional; Region: PRK13529 1052585011251 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052585011252 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1052585011253 NAD(P) binding site [chemical binding]; other site 1052585011254 thymidine kinase; Provisional; Region: PRK04296 1052585011255 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1052585011256 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1052585011257 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1052585011258 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1052585011259 RNA binding site [nucleotide binding]; other site 1052585011260 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1052585011261 multimer interface [polypeptide binding]; other site 1052585011262 Walker A motif; other site 1052585011263 ATP binding site [chemical binding]; other site 1052585011264 Walker B motif; other site 1052585011265 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1052585011266 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1052585011267 putative active site [active] 1052585011268 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1052585011269 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1052585011270 hinge; other site 1052585011271 active site 1052585011272 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1052585011273 active site 1052585011274 intersubunit interactions; other site 1052585011275 catalytic residue [active] 1052585011276 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1052585011277 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1052585011278 intersubunit interface [polypeptide binding]; other site 1052585011279 active site 1052585011280 zinc binding site [ion binding]; other site 1052585011281 Na+ binding site [ion binding]; other site 1052585011282 Response regulator receiver domain; Region: Response_reg; pfam00072 1052585011283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585011284 active site 1052585011285 phosphorylation site [posttranslational modification] 1052585011286 intermolecular recognition site; other site 1052585011287 dimerization interface [polypeptide binding]; other site 1052585011288 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1052585011289 CTP synthetase; Validated; Region: pyrG; PRK05380 1052585011290 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1052585011291 Catalytic site [active] 1052585011292 active site 1052585011293 UTP binding site [chemical binding]; other site 1052585011294 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1052585011295 active site 1052585011296 putative oxyanion hole; other site 1052585011297 catalytic triad [active] 1052585011298 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1052585011299 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052585011300 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1052585011301 FAD binding site [chemical binding]; other site 1052585011302 homotetramer interface [polypeptide binding]; other site 1052585011303 substrate binding pocket [chemical binding]; other site 1052585011304 catalytic base [active] 1052585011305 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1052585011306 Cysteine-rich domain; Region: CCG; pfam02754 1052585011307 Cysteine-rich domain; Region: CCG; pfam02754 1052585011308 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052585011309 PLD-like domain; Region: PLDc_2; pfam13091 1052585011310 putative active site [active] 1052585011311 catalytic site [active] 1052585011312 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052585011313 PLD-like domain; Region: PLDc_2; pfam13091 1052585011314 putative active site [active] 1052585011315 catalytic site [active] 1052585011316 UV-endonuclease UvdE; Region: UvdE; cl10036 1052585011317 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1052585011318 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1052585011319 folate binding site [chemical binding]; other site 1052585011320 NADP+ binding site [chemical binding]; other site 1052585011321 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585011322 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052585011323 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1052585011324 Walker A/P-loop; other site 1052585011325 ATP binding site [chemical binding]; other site 1052585011326 Q-loop/lid; other site 1052585011327 ABC transporter signature motif; other site 1052585011328 Walker B; other site 1052585011329 D-loop; other site 1052585011330 H-loop/switch region; other site 1052585011331 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1052585011332 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052585011333 putative active site [active] 1052585011334 catalytic site [active] 1052585011335 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052585011336 putative active site [active] 1052585011337 catalytic site [active] 1052585011338 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585011339 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1052585011340 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1052585011341 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1052585011342 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1052585011343 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1052585011344 [4Fe-4S] binding site [ion binding]; other site 1052585011345 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052585011346 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052585011347 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052585011348 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1052585011349 molybdopterin cofactor binding site; other site 1052585011350 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1052585011351 ligand binding site [chemical binding]; other site 1052585011352 flexible hinge region; other site 1052585011353 YwiC-like protein; Region: YwiC; pfam14256 1052585011354 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1052585011355 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1052585011356 ligand binding site [chemical binding]; other site 1052585011357 flexible hinge region; other site 1052585011358 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1052585011359 putative switch regulator; other site 1052585011360 non-specific DNA interactions [nucleotide binding]; other site 1052585011361 DNA binding site [nucleotide binding] 1052585011362 sequence specific DNA binding site [nucleotide binding]; other site 1052585011363 putative cAMP binding site [chemical binding]; other site 1052585011364 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1052585011365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011366 putative substrate translocation pore; other site 1052585011367 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1052585011368 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1052585011369 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1052585011370 active site 1052585011371 HIGH motif; other site 1052585011372 KMSK motif region; other site 1052585011373 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1052585011374 tRNA binding surface [nucleotide binding]; other site 1052585011375 anticodon binding site; other site 1052585011376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1052585011377 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 1052585011378 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1052585011379 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1052585011380 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585011381 FeS/SAM binding site; other site 1052585011382 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1052585011383 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1052585011384 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052585011385 Walker A/P-loop; other site 1052585011386 ATP binding site [chemical binding]; other site 1052585011387 Q-loop/lid; other site 1052585011388 ABC transporter signature motif; other site 1052585011389 Walker B; other site 1052585011390 D-loop; other site 1052585011391 H-loop/switch region; other site 1052585011392 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052585011393 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052585011394 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052585011395 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052585011396 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1052585011397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585011398 binding surface 1052585011399 TPR motif; other site 1052585011400 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1052585011401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585011402 TPR motif; other site 1052585011403 binding surface 1052585011404 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585011405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585011406 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1052585011407 Walker A/P-loop; other site 1052585011408 ATP binding site [chemical binding]; other site 1052585011409 Q-loop/lid; other site 1052585011410 ABC transporter signature motif; other site 1052585011411 Walker B; other site 1052585011412 D-loop; other site 1052585011413 H-loop/switch region; other site 1052585011414 agmatinase; Region: agmatinase; TIGR01230 1052585011415 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1052585011416 putative active site [active] 1052585011417 Mn binding site [ion binding]; other site 1052585011418 spermidine synthase; Provisional; Region: PRK00811 1052585011419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585011420 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1052585011421 Transglycosylase; Region: Transgly; pfam00912 1052585011422 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1052585011423 YwhD family; Region: YwhD; pfam08741 1052585011424 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1052585011425 Peptidase family M50; Region: Peptidase_M50; pfam02163 1052585011426 active site 1052585011427 putative substrate binding region [chemical binding]; other site 1052585011428 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1052585011429 active site 1 [active] 1052585011430 dimer interface [polypeptide binding]; other site 1052585011431 hexamer interface [polypeptide binding]; other site 1052585011432 active site 2 [active] 1052585011433 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585011434 MarR family; Region: MarR; pfam01047 1052585011435 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 1052585011436 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1052585011437 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1052585011438 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1052585011439 active site 1052585011440 dimer interface [polypeptide binding]; other site 1052585011441 motif 1; other site 1052585011442 motif 2; other site 1052585011443 motif 3; other site 1052585011444 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1052585011445 anticodon binding site; other site 1052585011446 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1052585011447 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1052585011448 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052585011449 Zn2+ binding site [ion binding]; other site 1052585011450 Mg2+ binding site [ion binding]; other site 1052585011451 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1052585011452 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1052585011453 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1052585011454 EamA-like transporter family; Region: EamA; pfam00892 1052585011455 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052585011456 EamA-like transporter family; Region: EamA; pfam00892 1052585011457 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1052585011458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585011459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585011460 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1052585011461 putative dimerization interface [polypeptide binding]; other site 1052585011462 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1052585011463 putative heme peroxidase; Provisional; Region: PRK12276 1052585011464 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052585011465 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1052585011466 putative NAD(P) binding site [chemical binding]; other site 1052585011467 putative active site [active] 1052585011468 transaminase; Reviewed; Region: PRK08068 1052585011469 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585011470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585011471 homodimer interface [polypeptide binding]; other site 1052585011472 catalytic residue [active] 1052585011473 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052585011474 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1052585011475 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1052585011476 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052585011477 classical (c) SDRs; Region: SDR_c; cd05233 1052585011478 NAD(P) binding site [chemical binding]; other site 1052585011479 active site 1052585011480 Cupin domain; Region: Cupin_2; pfam07883 1052585011481 Cupin domain; Region: Cupin_2; pfam07883 1052585011482 Prephenate dehydratase; Region: PDT; pfam00800 1052585011483 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052585011484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011485 putative substrate translocation pore; other site 1052585011486 S-methylmethionine transporter; Provisional; Region: PRK11387 1052585011487 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1052585011488 putative metal binding site [ion binding]; other site 1052585011489 putative dimer interface [polypeptide binding]; other site 1052585011490 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1052585011491 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1052585011492 Glutamate binding site [chemical binding]; other site 1052585011493 homodimer interface [polypeptide binding]; other site 1052585011494 NAD binding site [chemical binding]; other site 1052585011495 catalytic residues [active] 1052585011496 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1052585011497 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1052585011498 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1052585011499 NAD(P) binding site [chemical binding]; other site 1052585011500 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1052585011501 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1052585011502 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 1052585011503 NAD binding site [chemical binding]; other site 1052585011504 substrate binding site [chemical binding]; other site 1052585011505 homodimer interface [polypeptide binding]; other site 1052585011506 active site 1052585011507 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1052585011508 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1052585011509 substrate binding site; other site 1052585011510 tetramer interface; other site 1052585011511 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1052585011512 ligand binding site; other site 1052585011513 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1052585011514 NeuB family; Region: NeuB; pfam03102 1052585011515 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1052585011516 NeuB binding interface [polypeptide binding]; other site 1052585011517 putative substrate binding site [chemical binding]; other site 1052585011518 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052585011519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585011520 Coenzyme A binding pocket [chemical binding]; other site 1052585011521 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1052585011522 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1052585011523 inhibitor-cofactor binding pocket; inhibition site 1052585011524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585011525 catalytic residue [active] 1052585011526 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1052585011527 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1052585011528 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052585011529 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585011530 active site 1052585011531 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1052585011532 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1052585011533 Permease family; Region: Xan_ur_permease; pfam00860 1052585011534 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1052585011535 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1052585011536 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1052585011537 ligand binding site [chemical binding]; other site 1052585011538 active site 1052585011539 UGI interface [polypeptide binding]; other site 1052585011540 catalytic site [active] 1052585011541 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052585011542 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585011543 active site 1052585011544 Predicted transcriptional regulators [Transcription]; Region: COG1695 1052585011545 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1052585011546 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1052585011547 substrate binding site [chemical binding]; other site 1052585011548 ATP binding site [chemical binding]; other site 1052585011549 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1052585011550 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052585011551 substrate binding [chemical binding]; other site 1052585011552 active site 1052585011553 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052585011554 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1052585011555 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585011556 active site turn [active] 1052585011557 phosphorylation site [posttranslational modification] 1052585011558 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052585011559 formate/nitrite transporter; Region: fnt; TIGR00790 1052585011560 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052585011561 CAT RNA binding domain; Region: CAT_RBD; smart01061 1052585011562 PRD domain; Region: PRD; pfam00874 1052585011563 PRD domain; Region: PRD; pfam00874 1052585011564 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1052585011565 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052585011566 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1052585011567 putative active site [active] 1052585011568 catalytic triad [active] 1052585011569 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1052585011570 PA/protease domain interface [polypeptide binding]; other site 1052585011571 putative integrin binding motif; other site 1052585011572 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1052585011573 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1052585011574 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1052585011575 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052585011576 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1052585011577 dimer interface [polypeptide binding]; other site 1052585011578 FMN binding site [chemical binding]; other site 1052585011579 NADPH bind site [chemical binding]; other site 1052585011580 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1052585011581 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1052585011582 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1052585011583 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1052585011584 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1052585011585 Subunit I/III interface [polypeptide binding]; other site 1052585011586 Subunit III/IV interface [polypeptide binding]; other site 1052585011587 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1052585011588 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1052585011589 D-pathway; other site 1052585011590 Putative ubiquinol binding site [chemical binding]; other site 1052585011591 Low-spin heme (heme b) binding site [chemical binding]; other site 1052585011592 Putative water exit pathway; other site 1052585011593 Binuclear center (heme o3/CuB) [ion binding]; other site 1052585011594 K-pathway; other site 1052585011595 Putative proton exit pathway; other site 1052585011596 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1052585011597 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1052585011598 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1052585011599 Predicted membrane protein [Function unknown]; Region: COG2261 1052585011600 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 1052585011601 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1052585011602 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1052585011603 galactokinase; Provisional; Region: PRK05322 1052585011604 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1052585011605 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1052585011606 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052585011607 Predicted membrane protein [Function unknown]; Region: COG2246 1052585011608 GtrA-like protein; Region: GtrA; pfam04138 1052585011609 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585011610 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585011611 Anti-repressor SinI; Region: SinI; pfam08671 1052585011612 Predicted membrane protein [Function unknown]; Region: COG3162 1052585011613 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1052585011614 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1052585011615 Na binding site [ion binding]; other site 1052585011616 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1052585011617 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1052585011618 catalytic residues [active] 1052585011619 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1052585011620 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1052585011621 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1052585011622 Imelysin; Region: Peptidase_M75; pfam09375 1052585011623 Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases; Region: HR1; cl00087 1052585011624 FTR1 family protein; Region: TIGR00145 1052585011625 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1052585011626 thiamine phosphate binding site [chemical binding]; other site 1052585011627 active site 1052585011628 pyrophosphate binding site [ion binding]; other site 1052585011629 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1052585011630 substrate binding site [chemical binding]; other site 1052585011631 multimerization interface [polypeptide binding]; other site 1052585011632 ATP binding site [chemical binding]; other site 1052585011633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585011634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585011635 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1052585011636 putative dimerization interface [polypeptide binding]; other site 1052585011637 holin-like protein; Validated; Region: PRK01658 1052585011638 TIGR00659 family protein; Region: TIGR00659 1052585011639 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1052585011640 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1052585011641 PUA domain; Region: PUA; cl00607 1052585011642 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1052585011643 putative RNA binding site [nucleotide binding]; other site 1052585011644 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585011645 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052585011646 active site 1052585011647 metal binding site [ion binding]; metal-binding site 1052585011648 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1052585011649 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052585011650 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1052585011651 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052585011652 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052585011653 active site 1052585011654 catalytic residues [active] 1052585011655 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1052585011656 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585011657 active site turn [active] 1052585011658 phosphorylation site [posttranslational modification] 1052585011659 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052585011660 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052585011661 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1052585011662 PRD domain; Region: PRD; pfam00874 1052585011663 PRD domain; Region: PRD; pfam00874 1052585011664 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1052585011665 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1052585011666 Ligand binding site; other site 1052585011667 metal-binding site 1052585011668 Predicted integral membrane protein [Function unknown]; Region: COG5522 1052585011669 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585011670 MarR family; Region: MarR; pfam01047 1052585011671 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1052585011672 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1052585011673 active site 1052585011674 HIGH motif; other site 1052585011675 dimer interface [polypeptide binding]; other site 1052585011676 KMSKS motif; other site 1052585011677 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585011678 RNA binding surface [nucleotide binding]; other site 1052585011679 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1052585011680 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1052585011681 PA/protease domain interface [polypeptide binding]; other site 1052585011682 putative integrin binding motif; other site 1052585011683 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1052585011684 Peptidase family M28; Region: Peptidase_M28; pfam04389 1052585011685 metal binding site [ion binding]; metal-binding site 1052585011686 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052585011687 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1052585011688 synthetase active site [active] 1052585011689 NTP binding site [chemical binding]; other site 1052585011690 metal binding site [ion binding]; metal-binding site 1052585011691 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1052585011692 UbiA prenyltransferase family; Region: UbiA; pfam01040 1052585011693 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1052585011694 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1052585011695 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1052585011696 acyl-activating enzyme (AAE) consensus motif; other site 1052585011697 AMP binding site [chemical binding]; other site 1052585011698 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1052585011699 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1052585011700 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1052585011701 DltD N-terminal region; Region: DltD_N; pfam04915 1052585011702 DltD central region; Region: DltD_M; pfam04918 1052585011703 DltD C-terminal region; Region: DltD_C; pfam04914 1052585011704 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1052585011705 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1052585011706 putative NAD(P) binding site [chemical binding]; other site 1052585011707 active site 1052585011708 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1052585011709 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1052585011710 homodimer interface [polypeptide binding]; other site 1052585011711 substrate-cofactor binding pocket; other site 1052585011712 catalytic residue [active] 1052585011713 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1052585011714 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1052585011715 NAD binding site [chemical binding]; other site 1052585011716 sugar binding site [chemical binding]; other site 1052585011717 divalent metal binding site [ion binding]; other site 1052585011718 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585011719 dimer interface [polypeptide binding]; other site 1052585011720 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1052585011721 methionine cluster; other site 1052585011722 active site 1052585011723 phosphorylation site [posttranslational modification] 1052585011724 metal binding site [ion binding]; metal-binding site 1052585011725 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052585011726 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1052585011727 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1052585011728 active site 1052585011729 P-loop; other site 1052585011730 phosphorylation site [posttranslational modification] 1052585011731 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052585011732 HTH domain; Region: HTH_11; pfam08279 1052585011733 Mga helix-turn-helix domain; Region: Mga; pfam05043 1052585011734 PRD domain; Region: PRD; pfam00874 1052585011735 PRD domain; Region: PRD; pfam00874 1052585011736 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052585011737 active site 1052585011738 P-loop; other site 1052585011739 phosphorylation site [posttranslational modification] 1052585011740 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052585011741 active site 1052585011742 phosphorylation site [posttranslational modification] 1052585011743 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1052585011744 active site 1052585011745 DNA binding site [nucleotide binding] 1052585011746 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1052585011747 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1052585011748 tetramer interface [polypeptide binding]; other site 1052585011749 heme binding pocket [chemical binding]; other site 1052585011750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585011752 putative substrate translocation pore; other site 1052585011753 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1052585011754 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585011755 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052585011756 Walker A/P-loop; other site 1052585011757 ATP binding site [chemical binding]; other site 1052585011758 Q-loop/lid; other site 1052585011759 ABC transporter signature motif; other site 1052585011760 Walker B; other site 1052585011761 D-loop; other site 1052585011762 H-loop/switch region; other site 1052585011763 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1052585011764 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1052585011765 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 1052585011766 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585011767 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585011768 DNA binding residues [nucleotide binding] 1052585011769 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1052585011770 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1052585011771 Na binding site [ion binding]; other site 1052585011772 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1052585011773 putative substrate binding site [chemical binding]; other site 1052585011774 putative ATP binding site [chemical binding]; other site 1052585011775 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1052585011776 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052585011777 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1052585011778 Walker A/P-loop; other site 1052585011779 ATP binding site [chemical binding]; other site 1052585011780 Q-loop/lid; other site 1052585011781 ABC transporter signature motif; other site 1052585011782 Walker B; other site 1052585011783 D-loop; other site 1052585011784 H-loop/switch region; other site 1052585011785 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1052585011786 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052585011787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585011788 ATP binding site [chemical binding]; other site 1052585011789 Q-loop/lid; other site 1052585011790 ABC transporter signature motif; other site 1052585011791 Walker B; other site 1052585011792 D-loop; other site 1052585011793 H-loop/switch region; other site 1052585011794 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1052585011795 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1052585011796 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1052585011797 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1052585011798 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1052585011799 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1052585011800 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052585011801 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1052585011802 putative active site [active] 1052585011803 putative metal binding site [ion binding]; other site 1052585011804 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1052585011805 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1052585011806 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1052585011807 Walker A/P-loop; other site 1052585011808 ATP binding site [chemical binding]; other site 1052585011809 Q-loop/lid; other site 1052585011810 ABC transporter signature motif; other site 1052585011811 Walker B; other site 1052585011812 D-loop; other site 1052585011813 H-loop/switch region; other site 1052585011814 TOBE domain; Region: TOBE; pfam03459 1052585011815 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052585011816 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1052585011817 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1052585011818 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052585011819 NAD(P) binding site [chemical binding]; other site 1052585011820 catalytic residues [active] 1052585011821 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585011822 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585011823 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585011824 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052585011825 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1052585011826 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052585011827 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1052585011828 UDP-glucose 4-epimerase; Region: PLN02240 1052585011829 NAD binding site [chemical binding]; other site 1052585011830 homodimer interface [polypeptide binding]; other site 1052585011831 active site 1052585011832 substrate binding site [chemical binding]; other site 1052585011833 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 1052585011834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585011835 Histidine kinase; Region: HisKA_3; pfam07730 1052585011836 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1052585011837 ATP binding site [chemical binding]; other site 1052585011838 Mg2+ binding site [ion binding]; other site 1052585011839 G-X-G motif; other site 1052585011840 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585011841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585011842 active site 1052585011843 phosphorylation site [posttranslational modification] 1052585011844 intermolecular recognition site; other site 1052585011845 dimerization interface [polypeptide binding]; other site 1052585011846 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585011847 DNA binding residues [nucleotide binding] 1052585011848 dimerization interface [polypeptide binding]; other site 1052585011849 peptidase T; Region: peptidase-T; TIGR01882 1052585011850 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1052585011851 metal binding site [ion binding]; metal-binding site 1052585011852 dimer interface [polypeptide binding]; other site 1052585011853 Uncharacterized conserved protein [Function unknown]; Region: COG4894 1052585011854 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052585011855 substrate binding site [chemical binding]; other site 1052585011856 THF binding site; other site 1052585011857 zinc-binding site [ion binding]; other site 1052585011858 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052585011859 substrate binding site [chemical binding]; other site 1052585011860 THF binding site; other site 1052585011861 zinc-binding site [ion binding]; other site 1052585011862 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1052585011863 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1052585011864 NAD binding site [chemical binding]; other site 1052585011865 homotetramer interface [polypeptide binding]; other site 1052585011866 homodimer interface [polypeptide binding]; other site 1052585011867 substrate binding site [chemical binding]; other site 1052585011868 active site 1052585011869 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1052585011870 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1052585011871 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1052585011872 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1052585011873 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1052585011874 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1052585011875 nucleoside transporter; Region: nupC; TIGR00804 1052585011876 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1052585011877 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1052585011878 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052585011879 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1052585011880 hydroperoxidase II; Provisional; Region: katE; PRK11249 1052585011881 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1052585011882 tetramer interface [polypeptide binding]; other site 1052585011883 heme binding pocket [chemical binding]; other site 1052585011884 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1052585011885 domain interactions; other site 1052585011886 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1052585011887 Citrate transporter; Region: CitMHS; pfam03600 1052585011888 Predicted membrane protein [Function unknown]; Region: COG2323 1052585011889 hypothetical protein; Provisional; Region: PRK11281 1052585011890 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1052585011891 beta-galactosidase; Region: BGL; TIGR03356 1052585011892 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052585011893 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585011894 active site turn [active] 1052585011895 phosphorylation site [posttranslational modification] 1052585011896 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052585011897 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052585011898 HPr interaction site; other site 1052585011899 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585011900 active site 1052585011901 phosphorylation site [posttranslational modification] 1052585011902 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052585011903 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1052585011904 PRD domain; Region: PRD; pfam00874 1052585011905 PRD domain; Region: PRD; pfam00874 1052585011906 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1052585011907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011908 putative substrate translocation pore; other site 1052585011909 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1052585011910 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052585011911 ATP binding site [chemical binding]; other site 1052585011912 Mg++ binding site [ion binding]; other site 1052585011913 motif III; other site 1052585011914 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585011915 nucleotide binding region [chemical binding]; other site 1052585011916 ATP-binding site [chemical binding]; other site 1052585011917 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1052585011918 RNA binding site [nucleotide binding]; other site 1052585011919 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1052585011920 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052585011921 active site 1052585011922 catalytic triad [active] 1052585011923 Predicted transcriptional regulators [Transcription]; Region: COG1695 1052585011924 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1052585011925 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1052585011926 EamA-like transporter family; Region: EamA; pfam00892 1052585011927 RHS Repeat; Region: RHS_repeat; pfam05593 1052585011928 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1052585011929 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1052585011930 RHS Repeat; Region: RHS_repeat; pfam05593 1052585011931 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1052585011932 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1052585011933 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1052585011934 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052585011935 EamA-like transporter family; Region: EamA; pfam00892 1052585011936 EamA-like transporter family; Region: EamA; pfam00892 1052585011937 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1052585011938 Ligand Binding Site [chemical binding]; other site 1052585011939 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1052585011940 beta-galactosidase; Region: BGL; TIGR03356 1052585011941 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052585011942 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585011943 active site turn [active] 1052585011944 phosphorylation site [posttranslational modification] 1052585011945 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052585011946 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1052585011947 HPr interaction site; other site 1052585011948 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585011949 active site 1052585011950 phosphorylation site [posttranslational modification] 1052585011951 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052585011952 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1052585011953 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1052585011954 substrate binding site [chemical binding]; other site 1052585011955 active site 1052585011956 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585011957 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052585011958 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052585011959 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1052585011960 hexamer interface [polypeptide binding]; other site 1052585011961 RNA binding site [nucleotide binding]; other site 1052585011962 Histidine-zinc binding site [chemical binding]; other site 1052585011963 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1052585011964 active sites [active] 1052585011965 tetramer interface [polypeptide binding]; other site 1052585011966 urocanate hydratase; Provisional; Region: PRK05414 1052585011967 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1052585011968 imidazolonepropionase; Validated; Region: PRK09356 1052585011969 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1052585011970 active site 1052585011971 Agmatinase-like family; Region: Agmatinase-like; cd09990 1052585011972 agmatinase; Region: agmatinase; TIGR01230 1052585011973 active site 1052585011974 oligomer interface [polypeptide binding]; other site 1052585011975 Mn binding site [ion binding]; other site 1052585011976 S-methylmethionine transporter; Provisional; Region: PRK11387 1052585011977 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1052585011978 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1052585011979 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1052585011980 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1052585011981 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1052585011982 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1052585011983 Nucleoside recognition; Region: Gate; pfam07670 1052585011984 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1052585011985 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1052585011986 intersubunit interface [polypeptide binding]; other site 1052585011987 active site 1052585011988 catalytic residue [active] 1052585011989 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1052585011990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585011991 DNA binding residues [nucleotide binding] 1052585011992 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1052585011993 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1052585011994 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1052585011995 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1052585011996 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1052585011997 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1052585011998 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052585011999 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1052585012000 metal binding site [ion binding]; metal-binding site 1052585012001 dimer interface [polypeptide binding]; other site 1052585012002 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052585012003 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052585012004 Walker A/P-loop; other site 1052585012005 ATP binding site [chemical binding]; other site 1052585012006 Q-loop/lid; other site 1052585012007 ABC transporter signature motif; other site 1052585012008 Walker B; other site 1052585012009 D-loop; other site 1052585012010 H-loop/switch region; other site 1052585012011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585012012 dimer interface [polypeptide binding]; other site 1052585012013 conserved gate region; other site 1052585012014 putative PBP binding loops; other site 1052585012015 ABC-ATPase subunit interface; other site 1052585012016 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052585012017 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052585012018 substrate binding pocket [chemical binding]; other site 1052585012019 membrane-bound complex binding site; other site 1052585012020 hinge residues; other site 1052585012021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585012022 Coenzyme A binding pocket [chemical binding]; other site 1052585012023 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1052585012024 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1052585012025 active site 1052585012026 non-prolyl cis peptide bond; other site 1052585012027 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1052585012028 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1052585012029 active site 1052585012030 sugar phosphate phosphatase; Provisional; Region: PRK10513 1052585012031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585012032 active site 1052585012033 motif I; other site 1052585012034 motif II; other site 1052585012035 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585012036 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1052585012037 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052585012038 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052585012039 putative ligand binding residues [chemical binding]; other site 1052585012040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1052585012041 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585012042 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052585012043 Walker A/P-loop; other site 1052585012044 ATP binding site [chemical binding]; other site 1052585012045 Q-loop/lid; other site 1052585012046 ABC transporter signature motif; other site 1052585012047 Walker B; other site 1052585012048 D-loop; other site 1052585012049 H-loop/switch region; other site 1052585012050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585012051 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1052585012052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585012053 ATP binding site [chemical binding]; other site 1052585012054 Mg2+ binding site [ion binding]; other site 1052585012055 G-X-G motif; other site 1052585012056 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585012057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585012058 active site 1052585012059 phosphorylation site [posttranslational modification] 1052585012060 intermolecular recognition site; other site 1052585012061 dimerization interface [polypeptide binding]; other site 1052585012062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585012063 DNA binding site [nucleotide binding] 1052585012064 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1052585012065 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1052585012066 intersubunit interface [polypeptide binding]; other site 1052585012067 active site 1052585012068 zinc binding site [ion binding]; other site 1052585012069 Na+ binding site [ion binding]; other site 1052585012070 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052585012071 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1052585012072 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052585012073 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1052585012074 DNA interaction; other site 1052585012075 Metal-binding active site; metal-binding site 1052585012076 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585012077 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052585012078 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052585012079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585012080 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585012081 putative substrate translocation pore; other site 1052585012082 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052585012083 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1052585012084 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052585012085 PYR/PP interface [polypeptide binding]; other site 1052585012086 dimer interface [polypeptide binding]; other site 1052585012087 TPP binding site [chemical binding]; other site 1052585012088 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1052585012089 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1052585012090 TPP-binding site; other site 1052585012091 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052585012092 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1052585012093 substrate binding site [chemical binding]; other site 1052585012094 ATP binding site [chemical binding]; other site 1052585012095 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1052585012096 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1052585012097 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1052585012098 tetrameric interface [polypeptide binding]; other site 1052585012099 NAD binding site [chemical binding]; other site 1052585012100 catalytic residues [active] 1052585012101 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052585012102 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1052585012103 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1052585012104 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585012105 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052585012106 active site 1052585012107 catalytic tetrad [active] 1052585012108 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1052585012109 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052585012110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585012111 putative substrate translocation pore; other site 1052585012112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585012113 heat shock protein 90; Provisional; Region: PRK05218 1052585012114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585012115 ATP binding site [chemical binding]; other site 1052585012116 Mg2+ binding site [ion binding]; other site 1052585012117 G-X-G motif; other site 1052585012118 short chain dehydrogenase; Validated; Region: PRK08589 1052585012119 classical (c) SDRs; Region: SDR_c; cd05233 1052585012120 NAD(P) binding site [chemical binding]; other site 1052585012121 active site 1052585012122 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585012123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585012124 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585012125 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1052585012126 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1052585012127 NAD(P) binding site [chemical binding]; other site 1052585012128 catalytic residues [active] 1052585012129 RDD family; Region: RDD; pfam06271 1052585012130 RDD family; Region: RDD; pfam06271 1052585012131 Predicted membrane protein [Function unknown]; Region: COG2311 1052585012132 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1052585012133 Cupin domain; Region: Cupin_2; pfam07883 1052585012134 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1052585012135 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585012136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052585012137 short chain dehydrogenase; Provisional; Region: PRK07109 1052585012138 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1052585012139 putative NAD(P) binding site [chemical binding]; other site 1052585012140 active site 1052585012141 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585012142 MarR family; Region: MarR; pfam01047 1052585012143 LrgA family; Region: LrgA; cl00608 1052585012144 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1052585012145 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1052585012146 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1052585012147 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1052585012148 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1052585012149 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1052585012150 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1052585012151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585012152 DNA-binding site [nucleotide binding]; DNA binding site 1052585012153 FCD domain; Region: FCD; pfam07729 1052585012154 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1052585012155 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1052585012156 N- and C-terminal domain interface [polypeptide binding]; other site 1052585012157 active site 1052585012158 catalytic site [active] 1052585012159 metal binding site [ion binding]; metal-binding site 1052585012160 carbohydrate binding site [chemical binding]; other site 1052585012161 ATP binding site [chemical binding]; other site 1052585012162 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1052585012163 gluconate transporter; Region: gntP; TIGR00791 1052585012164 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1052585012165 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1052585012166 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1052585012167 peroxiredoxin; Region: AhpC; TIGR03137 1052585012168 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1052585012169 dimer interface [polypeptide binding]; other site 1052585012170 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1052585012171 catalytic triad [active] 1052585012172 peroxidatic and resolving cysteines [active] 1052585012173 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1052585012174 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1052585012175 catalytic residue [active] 1052585012176 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1052585012177 catalytic residues [active] 1052585012178 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052585012179 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585012180 Fic family protein [Function unknown]; Region: COG3177 1052585012181 Fic/DOC family; Region: Fic; pfam02661 1052585012182 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1052585012183 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1052585012184 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052585012185 beta-galactosidase; Region: BGL; TIGR03356 1052585012186 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052585012187 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585012188 active site turn [active] 1052585012189 phosphorylation site [posttranslational modification] 1052585012190 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052585012191 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052585012192 HPr interaction site; other site 1052585012193 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585012194 active site 1052585012195 phosphorylation site [posttranslational modification] 1052585012196 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052585012197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585012198 DNA-binding site [nucleotide binding]; DNA binding site 1052585012199 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1052585012200 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052585012201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1052585012202 Walker A/P-loop; other site 1052585012203 ATP binding site [chemical binding]; other site 1052585012204 Q-loop/lid; other site 1052585012205 ABC transporter signature motif; other site 1052585012206 Walker B; other site 1052585012207 D-loop; other site 1052585012208 H-loop/switch region; other site 1052585012209 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 1052585012210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585012211 FeS/SAM binding site; other site 1052585012212 exported signaling peptide, YydF/SAG_2028 family; Region: expor_sig_YdyF; TIGR04077 1052585012213 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1052585012214 AAA ATPase domain; Region: AAA_15; pfam13175 1052585012215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585012216 Walker A/P-loop; other site 1052585012217 ATP binding site [chemical binding]; other site 1052585012218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052585012219 ABC transporter signature motif; other site 1052585012220 Walker B; other site 1052585012221 D-loop; other site 1052585012222 H-loop/switch region; other site 1052585012223 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1052585012224 active site 1052585012225 metal binding site [ion binding]; metal-binding site 1052585012226 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1052585012227 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1052585012228 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1052585012229 NAD binding site [chemical binding]; other site 1052585012230 catalytic Zn binding site [ion binding]; other site 1052585012231 structural Zn binding site [ion binding]; other site 1052585012232 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1052585012233 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585012234 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052585012235 Coenzyme A binding pocket [chemical binding]; other site 1052585012236 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585012237 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585012238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585012239 binding surface 1052585012240 TPR motif; other site 1052585012241 Arginase family; Region: Arginase; cd09989 1052585012242 agmatinase; Region: agmatinase; TIGR01230 1052585012243 active site 1052585012244 Mn binding site [ion binding]; other site 1052585012245 oligomer interface [polypeptide binding]; other site 1052585012246 S-methylmethionine transporter; Provisional; Region: PRK11387 1052585012247 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1052585012248 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585012249 inhibitor-cofactor binding pocket; inhibition site 1052585012250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585012251 catalytic residue [active] 1052585012252 PAS domain; Region: PAS; smart00091 1052585012253 PAS domain; Region: PAS_9; pfam13426 1052585012254 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1052585012255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585012256 Walker A motif; other site 1052585012257 ATP binding site [chemical binding]; other site 1052585012258 Walker B motif; other site 1052585012259 arginine finger; other site 1052585012260 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1052585012261 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585012262 dimerization interface [polypeptide binding]; other site 1052585012263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585012264 dimer interface [polypeptide binding]; other site 1052585012265 phosphorylation site [posttranslational modification] 1052585012266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585012267 ATP binding site [chemical binding]; other site 1052585012268 Mg2+ binding site [ion binding]; other site 1052585012269 G-X-G motif; other site 1052585012270 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585012271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585012272 active site 1052585012273 phosphorylation site [posttranslational modification] 1052585012274 intermolecular recognition site; other site 1052585012275 dimerization interface [polypeptide binding]; other site 1052585012276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585012277 DNA binding site [nucleotide binding] 1052585012278 Predicted membrane protein [Function unknown]; Region: COG3212 1052585012279 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052585012280 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052585012281 Predicted membrane protein [Function unknown]; Region: COG3212 1052585012282 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052585012283 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052585012284 Predicted membrane protein [Function unknown]; Region: COG3212 1052585012285 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052585012286 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052585012287 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1052585012288 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1052585012289 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052585012290 protein binding site [polypeptide binding]; other site 1052585012291 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1052585012292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 1052585012293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1052585012294 YycH protein; Region: YycH; pfam07435 1052585012295 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1052585012296 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585012297 dimerization interface [polypeptide binding]; other site 1052585012298 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585012299 putative active site [active] 1052585012300 heme pocket [chemical binding]; other site 1052585012301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585012302 dimer interface [polypeptide binding]; other site 1052585012303 phosphorylation site [posttranslational modification] 1052585012304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585012305 ATP binding site [chemical binding]; other site 1052585012306 Mg2+ binding site [ion binding]; other site 1052585012307 G-X-G motif; other site 1052585012308 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585012309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585012310 active site 1052585012311 phosphorylation site [posttranslational modification] 1052585012312 intermolecular recognition site; other site 1052585012313 dimerization interface [polypeptide binding]; other site 1052585012314 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585012315 DNA binding site [nucleotide binding] 1052585012316 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1052585012317 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1052585012318 GDP-binding site [chemical binding]; other site 1052585012319 ACT binding site; other site 1052585012320 IMP binding site; other site 1052585012321 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585012322 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052585012323 active site 1052585012324 replicative DNA helicase; Provisional; Region: PRK05748 1052585012325 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1052585012326 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1052585012327 Walker A motif; other site 1052585012328 ATP binding site [chemical binding]; other site 1052585012329 Walker B motif; other site 1052585012330 DNA binding loops [nucleotide binding] 1052585012331 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1052585012332 YycC-like protein; Region: YycC; pfam14174 1052585012333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585012334 cyanate transporter; Region: CynX; TIGR00896 1052585012335 putative substrate translocation pore; other site 1052585012336 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1052585012337 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1052585012338 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1052585012339 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1052585012340 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1052585012341 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1052585012342 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1052585012343 DHH family; Region: DHH; pfam01368 1052585012344 DHHA1 domain; Region: DHHA1; pfam02272 1052585012345 Predicted membrane protein [Function unknown]; Region: COG4241 1052585012346 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1052585012347 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052585012348 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052585012349 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1052585012350 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1052585012351 DHHA2 domain; Region: DHHA2; pfam02833 1052585012352 ANTAR domain; Region: ANTAR; cl04297 1052585012353 D-galactonate transporter; Region: 2A0114; TIGR00893 1052585012354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585012355 putative substrate translocation pore; other site 1052585012356 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1052585012357 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052585012358 DNA binding residues [nucleotide binding] 1052585012359 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1052585012360 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1052585012361 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1052585012362 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052585012363 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052585012364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585012365 putative substrate translocation pore; other site 1052585012366 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585012367 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585012368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052585012369 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1052585012370 putative dimerization interface [polypeptide binding]; other site 1052585012371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585012372 Coenzyme A binding pocket [chemical binding]; other site 1052585012373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052585012374 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052585012375 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052585012376 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585012377 MarR family; Region: MarR; pfam01047 1052585012378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585012379 Coenzyme A binding pocket [chemical binding]; other site 1052585012380 Predicted membrane protein [Function unknown]; Region: COG2364 1052585012381 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1052585012382 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1052585012383 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585012384 dimerization interface [polypeptide binding]; other site 1052585012385 putative DNA binding site [nucleotide binding]; other site 1052585012386 putative Zn2+ binding site [ion binding]; other site 1052585012387 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1052585012388 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1052585012389 catalytic residues [active] 1052585012390 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1052585012391 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1052585012392 CAAX protease self-immunity; Region: Abi; pfam02517 1052585012393 benzoate transport; Region: 2A0115; TIGR00895 1052585012394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585012395 putative substrate translocation pore; other site 1052585012396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585012397 maltose O-acetyltransferase; Provisional; Region: PRK10092 1052585012398 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1052585012399 active site 1052585012400 substrate binding site [chemical binding]; other site 1052585012401 trimer interface [polypeptide binding]; other site 1052585012402 CoA binding site [chemical binding]; other site 1052585012403 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1052585012404 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585012405 putative metal binding site [ion binding]; other site 1052585012406 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585012407 DNA binding site [nucleotide binding] 1052585012408 domain linker motif; other site 1052585012409 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1052585012410 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1052585012411 putative dimerization interface [polypeptide binding]; other site 1052585012412 putative ligand binding site [chemical binding]; other site 1052585012413 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1052585012414 active site 1052585012415 putative catalytic site [active] 1052585012416 DNA binding site [nucleotide binding] 1052585012417 putative phosphate binding site [ion binding]; other site 1052585012418 metal binding site A [ion binding]; metal-binding site 1052585012419 AP binding site [nucleotide binding]; other site 1052585012420 metal binding site B [ion binding]; metal-binding site 1052585012421 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1052585012422 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1052585012423 dimer interface [polypeptide binding]; other site 1052585012424 ssDNA binding site [nucleotide binding]; other site 1052585012425 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585012426 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1052585012427 GTP-binding protein YchF; Reviewed; Region: PRK09601 1052585012428 YchF GTPase; Region: YchF; cd01900 1052585012429 Switch II region; other site 1052585012430 G3 box; other site 1052585012431 GTP/Mg2+ binding site [chemical binding]; other site 1052585012432 G4 box; other site 1052585012433 G5 box; other site 1052585012434 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1052585012435 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1052585012436 G1 box; other site 1052585012437 GTP/Mg2+ binding site [chemical binding]; other site 1052585012438 G2 box; other site 1052585012439 Switch I region; other site 1052585012440 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1052585012441 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1052585012442 putative [4Fe-4S] binding site [ion binding]; other site 1052585012443 putative molybdopterin cofactor binding site [chemical binding]; other site 1052585012444 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1052585012445 molybdopterin cofactor binding site; other site 1052585012446 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1052585012447 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1052585012448 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1052585012449 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1052585012450 ParB-like nuclease domain; Region: ParB; smart00470 1052585012451 KorB domain; Region: KorB; pfam08535 1052585012452 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1052585012453 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1052585012454 P-loop; other site 1052585012455 Magnesium ion binding site [ion binding]; other site 1052585012456 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1052585012457 Magnesium ion binding site [ion binding]; other site 1052585012458 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1052585012459 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1052585012460 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1052585012461 ParB-like nuclease domain; Region: ParB; smart00470 1052585012462 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1052585012463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585012464 S-adenosylmethionine binding site [chemical binding]; other site 1052585012465 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1052585012466 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1052585012467 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1052585012468 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1052585012469 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1052585012470 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1052585012471 G1 box; other site 1052585012472 GTP/Mg2+ binding site [chemical binding]; other site 1052585012473 Switch I region; other site 1052585012474 G2 box; other site 1052585012475 Switch II region; other site 1052585012476 G3 box; other site 1052585012477 G4 box; other site 1052585012478 G5 box; other site 1052585012479 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1052585012480 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1052585012481 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1052585012482 G-X-X-G motif; other site 1052585012483 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1052585012484 RxxxH motif; other site 1052585012485 OxaA-like protein precursor; Validated; Region: PRK02944 1052585012486 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1052585012487 ribonuclease P; Reviewed; Region: rnpA; PRK00499