-- dump date 20140618_225532 -- class Genbank::misc_feature -- table misc_feature_note -- id note 655816000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 655816000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 655816000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816000004 Walker A motif; other site 655816000005 ATP binding site [chemical binding]; other site 655816000006 Walker B motif; other site 655816000007 arginine finger; other site 655816000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 655816000009 DnaA box-binding interface [nucleotide binding]; other site 655816000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 655816000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 655816000012 putative DNA binding surface [nucleotide binding]; other site 655816000013 dimer interface [polypeptide binding]; other site 655816000014 beta-clamp/clamp loader binding surface; other site 655816000015 beta-clamp/translesion DNA polymerase binding surface; other site 655816000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 655816000017 recF protein; Region: recf; TIGR00611 655816000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 655816000019 Walker A/P-loop; other site 655816000020 ATP binding site [chemical binding]; other site 655816000021 Q-loop/lid; other site 655816000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655816000023 ABC transporter signature motif; other site 655816000024 Walker B; other site 655816000025 D-loop; other site 655816000026 H-loop/switch region; other site 655816000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 655816000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816000029 ATP binding site [chemical binding]; other site 655816000030 Mg2+ binding site [ion binding]; other site 655816000031 G-X-G motif; other site 655816000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 655816000033 anchoring element; other site 655816000034 dimer interface [polypeptide binding]; other site 655816000035 ATP binding site [chemical binding]; other site 655816000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 655816000037 active site 655816000038 putative metal-binding site [ion binding]; other site 655816000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 655816000040 DNA gyrase subunit A; Validated; Region: PRK05560 655816000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 655816000042 CAP-like domain; other site 655816000043 active site 655816000044 primary dimer interface [polypeptide binding]; other site 655816000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816000051 YaaC-like Protein; Region: YaaC; pfam14175 655816000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 655816000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 655816000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 655816000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 655816000056 active site 655816000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 655816000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 655816000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 655816000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 655816000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 655816000062 active site 655816000063 multimer interface [polypeptide binding]; other site 655816000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 655816000065 predicted active site [active] 655816000066 catalytic triad [active] 655816000067 seryl-tRNA synthetase; Provisional; Region: PRK05431 655816000068 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 655816000069 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 655816000070 dimer interface [polypeptide binding]; other site 655816000071 active site 655816000072 motif 1; other site 655816000073 motif 2; other site 655816000074 motif 3; other site 655816000075 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 655816000076 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 655816000077 Substrate-binding site [chemical binding]; other site 655816000078 Substrate specificity [chemical binding]; other site 655816000079 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 655816000080 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 655816000081 Substrate-binding site [chemical binding]; other site 655816000082 Substrate specificity [chemical binding]; other site 655816000083 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 655816000084 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816000085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816000086 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 655816000087 active site 655816000088 Isochorismatase family; Region: Isochorismatase; pfam00857 655816000089 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 655816000090 catalytic triad [active] 655816000091 conserved cis-peptide bond; other site 655816000092 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 655816000093 nucleoside/Zn binding site; other site 655816000094 dimer interface [polypeptide binding]; other site 655816000095 catalytic motif [active] 655816000096 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 655816000097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816000098 Walker A motif; other site 655816000099 ATP binding site [chemical binding]; other site 655816000100 Walker B motif; other site 655816000101 arginine finger; other site 655816000102 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 655816000103 hypothetical protein; Validated; Region: PRK00153 655816000104 recombination protein RecR; Reviewed; Region: recR; PRK00076 655816000105 RecR protein; Region: RecR; pfam02132 655816000106 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 655816000107 putative active site [active] 655816000108 putative metal-binding site [ion binding]; other site 655816000109 tetramer interface [polypeptide binding]; other site 655816000110 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 655816000111 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 655816000112 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 655816000113 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 655816000114 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 655816000115 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 655816000116 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 655816000117 homodimer interface [polypeptide binding]; other site 655816000118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816000119 catalytic residue [active] 655816000120 thymidylate kinase; Validated; Region: tmk; PRK00698 655816000121 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 655816000122 TMP-binding site; other site 655816000123 ATP-binding site [chemical binding]; other site 655816000124 Protein of unknown function (DUF970); Region: DUF970; pfam06153 655816000125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 655816000126 DNA polymerase III subunit delta'; Validated; Region: PRK08058 655816000127 DNA polymerase III subunit delta'; Validated; Region: PRK08485 655816000128 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 655816000129 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 655816000130 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 655816000131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816000132 S-adenosylmethionine binding site [chemical binding]; other site 655816000133 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 655816000134 GIY-YIG motif/motif A; other site 655816000135 putative active site [active] 655816000136 putative metal binding site [ion binding]; other site 655816000137 Predicted methyltransferases [General function prediction only]; Region: COG0313 655816000138 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 655816000139 putative SAM binding site [chemical binding]; other site 655816000140 putative homodimer interface [polypeptide binding]; other site 655816000141 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 655816000142 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 655816000143 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 655816000144 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 655816000145 active site 655816000146 HIGH motif; other site 655816000147 KMSKS motif; other site 655816000148 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 655816000149 tRNA binding surface [nucleotide binding]; other site 655816000150 anticodon binding site; other site 655816000151 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 655816000152 dimer interface [polypeptide binding]; other site 655816000153 putative tRNA-binding site [nucleotide binding]; other site 655816000154 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 655816000155 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 655816000156 active site 655816000157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 655816000158 Domain of unknown function (DUF348); Region: DUF348; pfam03990 655816000159 Domain of unknown function (DUF348); Region: DUF348; pfam03990 655816000160 Domain of unknown function (DUF348); Region: DUF348; pfam03990 655816000161 G5 domain; Region: G5; pfam07501 655816000162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 655816000163 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 655816000164 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 655816000165 putative active site [active] 655816000166 putative metal binding site [ion binding]; other site 655816000167 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 655816000168 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 655816000169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816000170 S-adenosylmethionine binding site [chemical binding]; other site 655816000171 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 655816000172 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 655816000173 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 655816000174 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 655816000175 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 655816000176 pur operon repressor; Provisional; Region: PRK09213 655816000177 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 655816000178 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816000179 active site 655816000180 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 655816000181 homotrimer interaction site [polypeptide binding]; other site 655816000182 putative active site [active] 655816000183 regulatory protein SpoVG; Reviewed; Region: PRK13259 655816000184 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 655816000185 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 655816000186 Substrate binding site; other site 655816000187 Mg++ binding site; other site 655816000188 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 655816000189 active site 655816000190 substrate binding site [chemical binding]; other site 655816000191 CoA binding site [chemical binding]; other site 655816000192 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 655816000193 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 655816000194 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816000195 active site 655816000196 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 655816000197 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 655816000198 5S rRNA interface [nucleotide binding]; other site 655816000199 CTC domain interface [polypeptide binding]; other site 655816000200 L16 interface [polypeptide binding]; other site 655816000201 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 655816000202 putative active site [active] 655816000203 catalytic residue [active] 655816000204 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 655816000205 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 655816000206 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 655816000207 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816000208 ATP binding site [chemical binding]; other site 655816000209 putative Mg++ binding site [ion binding]; other site 655816000210 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816000211 nucleotide binding region [chemical binding]; other site 655816000212 ATP-binding site [chemical binding]; other site 655816000213 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 655816000214 stage V sporulation protein T; Region: spore_V_T; TIGR02851 655816000215 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 655816000216 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 655816000217 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 655816000218 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 655816000219 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 655816000220 putative SAM binding site [chemical binding]; other site 655816000221 putative homodimer interface [polypeptide binding]; other site 655816000222 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 655816000223 homodimer interface [polypeptide binding]; other site 655816000224 metal binding site [ion binding]; metal-binding site 655816000225 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 655816000226 homodimer interface [polypeptide binding]; other site 655816000227 active site 655816000228 putative chemical substrate binding site [chemical binding]; other site 655816000229 metal binding site [ion binding]; metal-binding site 655816000230 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816000231 RNA binding surface [nucleotide binding]; other site 655816000232 sporulation protein YabP; Region: spore_yabP; TIGR02892 655816000233 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 655816000234 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 655816000235 Septum formation initiator; Region: DivIC; pfam04977 655816000236 hypothetical protein; Provisional; Region: PRK08582 655816000237 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 655816000238 RNA binding site [nucleotide binding]; other site 655816000239 stage II sporulation protein E; Region: spore_II_E; TIGR02865 655816000240 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 655816000241 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 655816000242 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 655816000243 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 655816000244 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 655816000245 metal ion-dependent adhesion site (MIDAS); other site 655816000246 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 655816000247 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816000248 active site 655816000249 ATP binding site [chemical binding]; other site 655816000250 substrate binding site [chemical binding]; other site 655816000251 activation loop (A-loop); other site 655816000252 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 655816000253 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 655816000254 Ligand Binding Site [chemical binding]; other site 655816000255 TilS substrate C-terminal domain; Region: TilS_C; smart00977 655816000256 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816000257 active site 655816000258 FtsH Extracellular; Region: FtsH_ext; pfam06480 655816000259 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 655816000260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816000261 Walker A motif; other site 655816000262 ATP binding site [chemical binding]; other site 655816000263 Walker B motif; other site 655816000264 arginine finger; other site 655816000265 Peptidase family M41; Region: Peptidase_M41; pfam01434 655816000266 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655816000267 nucleotide binding site [chemical binding]; other site 655816000268 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 655816000269 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 655816000270 dimerization interface [polypeptide binding]; other site 655816000271 domain crossover interface; other site 655816000272 redox-dependent activation switch; other site 655816000273 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 655816000274 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 655816000275 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 655816000276 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 655816000277 dimer interface [polypeptide binding]; other site 655816000278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816000279 catalytic residue [active] 655816000280 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 655816000281 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 655816000282 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 655816000283 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 655816000284 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 655816000285 glutamine binding [chemical binding]; other site 655816000286 catalytic triad [active] 655816000287 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 655816000288 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 655816000289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816000290 catalytic residue [active] 655816000291 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 655816000292 dihydropteroate synthase; Region: DHPS; TIGR01496 655816000293 substrate binding pocket [chemical binding]; other site 655816000294 dimer interface [polypeptide binding]; other site 655816000295 inhibitor binding site; inhibition site 655816000296 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 655816000297 homooctamer interface [polypeptide binding]; other site 655816000298 active site 655816000299 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 655816000300 catalytic center binding site [active] 655816000301 ATP binding site [chemical binding]; other site 655816000302 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 655816000303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816000304 non-specific DNA binding site [nucleotide binding]; other site 655816000305 salt bridge; other site 655816000306 sequence-specific DNA binding site [nucleotide binding]; other site 655816000307 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 655816000308 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 655816000309 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 655816000310 FMN binding site [chemical binding]; other site 655816000311 active site 655816000312 catalytic residues [active] 655816000313 substrate binding site [chemical binding]; other site 655816000314 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 655816000315 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 655816000316 dimer interface [polypeptide binding]; other site 655816000317 putative anticodon binding site; other site 655816000318 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 655816000319 motif 1; other site 655816000320 active site 655816000321 motif 2; other site 655816000322 motif 3; other site 655816000323 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 655816000324 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 655816000325 UvrB/uvrC motif; Region: UVR; pfam02151 655816000326 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 655816000327 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 655816000328 ADP binding site [chemical binding]; other site 655816000329 phosphagen binding site; other site 655816000330 substrate specificity loop; other site 655816000331 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 655816000332 Clp amino terminal domain; Region: Clp_N; pfam02861 655816000333 Clp amino terminal domain; Region: Clp_N; pfam02861 655816000334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816000335 Walker A motif; other site 655816000336 ATP binding site [chemical binding]; other site 655816000337 Walker B motif; other site 655816000338 arginine finger; other site 655816000339 UvrB/uvrC motif; Region: UVR; pfam02151 655816000340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816000341 Walker A motif; other site 655816000342 ATP binding site [chemical binding]; other site 655816000343 Walker B motif; other site 655816000344 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 655816000345 DNA repair protein RadA; Provisional; Region: PRK11823 655816000346 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 655816000347 Walker A motif/ATP binding site; other site 655816000348 ATP binding site [chemical binding]; other site 655816000349 Walker B motif; other site 655816000350 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 655816000351 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 655816000352 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 655816000353 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 655816000354 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 655816000355 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 655816000356 putative active site [active] 655816000357 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 655816000358 substrate binding site; other site 655816000359 dimer interface; other site 655816000360 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 655816000361 homotrimer interaction site [polypeptide binding]; other site 655816000362 zinc binding site [ion binding]; other site 655816000363 CDP-binding sites; other site 655816000364 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 655816000365 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 655816000366 active site 655816000367 HIGH motif; other site 655816000368 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 655816000369 active site 655816000370 KMSKS motif; other site 655816000371 serine O-acetyltransferase; Region: cysE; TIGR01172 655816000372 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 655816000373 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 655816000374 trimer interface [polypeptide binding]; other site 655816000375 active site 655816000376 substrate binding site [chemical binding]; other site 655816000377 CoA binding site [chemical binding]; other site 655816000378 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 655816000379 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 655816000380 active site 655816000381 HIGH motif; other site 655816000382 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 655816000383 KMSKS motif; other site 655816000384 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 655816000385 tRNA binding surface [nucleotide binding]; other site 655816000386 anticodon binding site; other site 655816000387 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 655816000388 active site 655816000389 metal binding site [ion binding]; metal-binding site 655816000390 dimerization interface [polypeptide binding]; other site 655816000391 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 655816000392 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 655816000393 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 655816000394 YacP-like NYN domain; Region: NYN_YacP; cl01491 655816000395 RNA polymerase factor sigma-70; Validated; Region: PRK08295 655816000396 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816000397 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 655816000398 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 655816000399 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 655816000400 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 655816000401 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 655816000402 putative homodimer interface [polypeptide binding]; other site 655816000403 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 655816000404 heterodimer interface [polypeptide binding]; other site 655816000405 homodimer interface [polypeptide binding]; other site 655816000406 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 655816000407 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 655816000408 23S rRNA interface [nucleotide binding]; other site 655816000409 L7/L12 interface [polypeptide binding]; other site 655816000410 putative thiostrepton binding site; other site 655816000411 L25 interface [polypeptide binding]; other site 655816000412 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 655816000413 mRNA/rRNA interface [nucleotide binding]; other site 655816000414 L10 leader; ribosomal protein gene, untranslated leader; autoregulatory structure; BSUW23_misc_RNA_3 655816000415 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 655816000416 23S rRNA interface [nucleotide binding]; other site 655816000417 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 655816000418 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 655816000419 core dimer interface [polypeptide binding]; other site 655816000420 peripheral dimer interface [polypeptide binding]; other site 655816000421 L10 interface [polypeptide binding]; other site 655816000422 L11 interface [polypeptide binding]; other site 655816000423 putative EF-Tu interaction site [polypeptide binding]; other site 655816000424 putative EF-G interaction site [polypeptide binding]; other site 655816000425 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 655816000426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816000427 S-adenosylmethionine binding site [chemical binding]; other site 655816000428 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 655816000429 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 655816000430 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 655816000431 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 655816000432 RPB1 interaction site [polypeptide binding]; other site 655816000433 RPB10 interaction site [polypeptide binding]; other site 655816000434 RPB11 interaction site [polypeptide binding]; other site 655816000435 RPB3 interaction site [polypeptide binding]; other site 655816000436 RPB12 interaction site [polypeptide binding]; other site 655816000437 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 655816000438 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 655816000439 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 655816000440 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 655816000441 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 655816000442 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 655816000443 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 655816000444 G-loop; other site 655816000445 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 655816000446 DNA binding site [nucleotide binding] 655816000447 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 655816000448 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 655816000449 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 655816000450 S17 interaction site [polypeptide binding]; other site 655816000451 S8 interaction site; other site 655816000452 16S rRNA interaction site [nucleotide binding]; other site 655816000453 streptomycin interaction site [chemical binding]; other site 655816000454 23S rRNA interaction site [nucleotide binding]; other site 655816000455 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 655816000456 30S ribosomal protein S7; Validated; Region: PRK05302 655816000457 elongation factor G; Reviewed; Region: PRK00007 655816000458 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 655816000459 G1 box; other site 655816000460 putative GEF interaction site [polypeptide binding]; other site 655816000461 GTP/Mg2+ binding site [chemical binding]; other site 655816000462 Switch I region; other site 655816000463 G2 box; other site 655816000464 G3 box; other site 655816000465 Switch II region; other site 655816000466 G4 box; other site 655816000467 G5 box; other site 655816000468 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 655816000469 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 655816000470 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 655816000471 elongation factor Tu; Reviewed; Region: PRK00049 655816000472 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 655816000473 G1 box; other site 655816000474 GEF interaction site [polypeptide binding]; other site 655816000475 GTP/Mg2+ binding site [chemical binding]; other site 655816000476 Switch I region; other site 655816000477 G2 box; other site 655816000478 G3 box; other site 655816000479 Switch II region; other site 655816000480 G4 box; other site 655816000481 G5 box; other site 655816000482 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 655816000483 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 655816000484 Antibiotic Binding Site [chemical binding]; other site 655816000485 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 655816000486 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 655816000487 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 655816000488 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 655816000489 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 655816000490 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 655816000491 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 655816000492 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 655816000493 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 655816000494 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 655816000495 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 655816000496 putative translocon binding site; other site 655816000497 protein-rRNA interface [nucleotide binding]; other site 655816000498 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 655816000499 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 655816000500 G-X-X-G motif; other site 655816000501 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 655816000502 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 655816000503 23S rRNA interface [nucleotide binding]; other site 655816000504 5S rRNA interface [nucleotide binding]; other site 655816000505 putative antibiotic binding site [chemical binding]; other site 655816000506 L25 interface [polypeptide binding]; other site 655816000507 L27 interface [polypeptide binding]; other site 655816000508 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 655816000509 23S rRNA interface [nucleotide binding]; other site 655816000510 putative translocon interaction site; other site 655816000511 signal recognition particle (SRP54) interaction site; other site 655816000512 L23 interface [polypeptide binding]; other site 655816000513 trigger factor interaction site; other site 655816000514 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 655816000515 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 655816000516 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 655816000517 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 655816000518 RNA binding site [nucleotide binding]; other site 655816000519 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 655816000520 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 655816000521 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 655816000522 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 655816000523 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 655816000524 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 655816000525 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 655816000526 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 655816000527 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 655816000528 5S rRNA interface [nucleotide binding]; other site 655816000529 L27 interface [polypeptide binding]; other site 655816000530 23S rRNA interface [nucleotide binding]; other site 655816000531 L5 interface [polypeptide binding]; other site 655816000532 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 655816000533 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 655816000534 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 655816000535 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 655816000536 23S rRNA binding site [nucleotide binding]; other site 655816000537 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 655816000538 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 655816000539 SecY translocase; Region: SecY; pfam00344 655816000540 adenylate kinase; Reviewed; Region: adk; PRK00279 655816000541 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 655816000542 AMP-binding site [chemical binding]; other site 655816000543 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 655816000544 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 655816000545 active site 655816000546 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 655816000547 RNA binding site [nucleotide binding]; other site 655816000548 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 655816000549 rRNA binding site [nucleotide binding]; other site 655816000550 predicted 30S ribosome binding site; other site 655816000551 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 655816000552 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 655816000553 30S ribosomal protein S13; Region: bact_S13; TIGR03631 655816000554 30S ribosomal protein S11; Validated; Region: PRK05309 655816000555 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 655816000556 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 655816000557 alphaNTD homodimer interface [polypeptide binding]; other site 655816000558 alphaNTD - beta interaction site [polypeptide binding]; other site 655816000559 alphaNTD - beta' interaction site [polypeptide binding]; other site 655816000560 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 655816000561 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 655816000562 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 655816000563 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 655816000564 Walker A/P-loop; other site 655816000565 ATP binding site [chemical binding]; other site 655816000566 Q-loop/lid; other site 655816000567 ABC transporter signature motif; other site 655816000568 Walker B; other site 655816000569 D-loop; other site 655816000570 H-loop/switch region; other site 655816000571 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 655816000572 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 655816000573 Walker A/P-loop; other site 655816000574 ATP binding site [chemical binding]; other site 655816000575 Q-loop/lid; other site 655816000576 ABC transporter signature motif; other site 655816000577 Walker B; other site 655816000578 D-loop; other site 655816000579 H-loop/switch region; other site 655816000580 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 655816000581 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 655816000582 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 655816000583 dimerization interface 3.5A [polypeptide binding]; other site 655816000584 active site 655816000585 L13 leader; ribosomal protein gene, untranslated leader; autoregulatory structure; BSUW23_misc_RNA_4 655816000586 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 655816000587 23S rRNA interface [nucleotide binding]; other site 655816000588 L3 interface [polypeptide binding]; other site 655816000589 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 655816000590 Methyltransferase domain; Region: Methyltransf_31; pfam13847 655816000591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816000592 S-adenosylmethionine binding site [chemical binding]; other site 655816000593 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 655816000594 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 655816000595 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 655816000596 active site 655816000597 metal binding site [ion binding]; metal-binding site 655816000598 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 655816000599 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 655816000600 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 655816000601 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 655816000602 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 655816000603 NodB motif; other site 655816000604 putative active site [active] 655816000605 putative catalytic site [active] 655816000606 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 655816000607 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 655816000608 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 655816000609 Sulfate transporter family; Region: Sulfate_transp; pfam00916 655816000610 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 655816000611 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 655816000612 Sodium Bile acid symporter family; Region: SBF; cl17470 655816000613 Putative esterase; Region: Esterase; pfam00756 655816000614 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 655816000615 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 655816000616 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816000617 dimer interface [polypeptide binding]; other site 655816000618 putative PBP binding regions; other site 655816000619 ABC-ATPase subunit interface; other site 655816000620 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655816000621 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816000622 ABC-ATPase subunit interface; other site 655816000623 dimer interface [polypeptide binding]; other site 655816000624 putative PBP binding regions; other site 655816000625 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 655816000626 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 655816000627 putative ligand binding residues [chemical binding]; other site 655816000628 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816000629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816000630 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 655816000631 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 655816000632 intersubunit interface [polypeptide binding]; other site 655816000633 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 655816000634 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 655816000635 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 655816000636 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 655816000637 putative periplasmic esterase; Provisional; Region: PRK03642 655816000638 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 655816000639 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 655816000640 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816000641 active site turn [active] 655816000642 phosphorylation site [posttranslational modification] 655816000643 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655816000644 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 655816000645 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 655816000646 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 655816000647 putative active site [active] 655816000648 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 655816000649 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 655816000650 putative active site [active] 655816000651 Uncharacterized conserved protein [Function unknown]; Region: COG1683 655816000652 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 655816000653 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816000654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816000655 DNA binding residues [nucleotide binding] 655816000656 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 655816000657 Putative zinc-finger; Region: zf-HC2; pfam13490 655816000658 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 655816000659 Uncharacterized conserved protein [Function unknown]; Region: COG1624 655816000660 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 655816000661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 655816000662 YbbR-like protein; Region: YbbR; pfam07949 655816000663 YbbR-like protein; Region: YbbR; pfam07949 655816000664 YbbR-like protein; Region: YbbR; pfam07949 655816000665 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 655816000666 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 655816000667 active site 655816000668 substrate binding site [chemical binding]; other site 655816000669 metal binding site [ion binding]; metal-binding site 655816000670 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 655816000671 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 655816000672 glutaminase active site [active] 655816000673 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 655816000674 dimer interface [polypeptide binding]; other site 655816000675 active site 655816000676 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 655816000677 dimer interface [polypeptide binding]; other site 655816000678 active site 655816000679 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 655816000680 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 655816000681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 655816000682 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 655816000683 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 655816000684 zinc binding site [ion binding]; other site 655816000685 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 655816000686 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 655816000687 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816000688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816000689 active site 655816000690 phosphorylation site [posttranslational modification] 655816000691 intermolecular recognition site; other site 655816000692 dimerization interface [polypeptide binding]; other site 655816000693 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816000694 DNA binding site [nucleotide binding] 655816000695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816000696 HAMP domain; Region: HAMP; pfam00672 655816000697 dimerization interface [polypeptide binding]; other site 655816000698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816000699 dimer interface [polypeptide binding]; other site 655816000700 phosphorylation site [posttranslational modification] 655816000701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816000702 ATP binding site [chemical binding]; other site 655816000703 Mg2+ binding site [ion binding]; other site 655816000704 G-X-G motif; other site 655816000705 rhizocticin biosynthetic gene cluster 655816000706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816000707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816000708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816000709 dimerization interface [polypeptide binding]; other site 655816000710 threonine synthase; Validated; Region: PRK06260 655816000711 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 655816000712 homodimer interface [polypeptide binding]; other site 655816000713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816000714 catalytic residue [active] 655816000715 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 655816000716 putative transporter; Provisional; Region: PRK10054 655816000717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000718 putative substrate translocation pore; other site 655816000719 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 655816000720 PYR/PP interface [polypeptide binding]; other site 655816000721 dimer interface [polypeptide binding]; other site 655816000722 TPP binding site [chemical binding]; other site 655816000723 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 655816000724 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 655816000725 TPP-binding site [chemical binding]; other site 655816000726 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 655816000727 active site 655816000728 catalytic residues [active] 655816000729 metal binding site [ion binding]; metal-binding site 655816000730 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 655816000731 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 655816000732 tetramer interface [polypeptide binding]; other site 655816000733 active site 655816000734 Mg2+/Mn2+ binding site [ion binding]; other site 655816000735 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 655816000736 active site 655816000737 metal-binding site [ion binding] 655816000738 nucleotide-binding site [chemical binding]; other site 655816000739 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 655816000740 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 655816000741 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816000742 catalytic residue [active] 655816000743 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 655816000744 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 655816000745 active site 655816000746 metal binding site [ion binding]; metal-binding site 655816000747 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 655816000748 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 655816000749 Catalytic domain of Protein Kinases; Region: PKc; cd00180 655816000750 active site 655816000751 ATP binding site [chemical binding]; other site 655816000752 substrate binding site [chemical binding]; other site 655816000753 activation loop (A-loop); other site 655816000754 putative transport protein YifK; Provisional; Region: PRK10746 655816000755 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 655816000756 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 655816000757 Cytochrome P450; Region: p450; cl12078 655816000758 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 655816000759 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 655816000760 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 655816000761 PhoU domain; Region: PhoU; pfam01895 655816000762 PhoU domain; Region: PhoU; pfam01895 655816000763 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 655816000764 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 655816000765 active site 655816000766 catalytic site [active] 655816000767 metal binding site [ion binding]; metal-binding site 655816000768 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 655816000769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000770 putative substrate translocation pore; other site 655816000771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000772 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 655816000773 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816000774 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 655816000775 non-specific DNA interactions [nucleotide binding]; other site 655816000776 DNA binding site [nucleotide binding] 655816000777 sequence specific DNA binding site [nucleotide binding]; other site 655816000778 putative cAMP binding site [chemical binding]; other site 655816000779 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 655816000780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816000781 Coenzyme A binding pocket [chemical binding]; other site 655816000782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000783 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816000784 putative substrate translocation pore; other site 655816000785 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 655816000786 EamA-like transporter family; Region: EamA; pfam00892 655816000787 EamA-like transporter family; Region: EamA; pfam00892 655816000788 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 655816000789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816000790 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816000791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816000792 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 655816000793 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816000794 ATP-grasp domain; Region: ATP-grasp; pfam02222 655816000795 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 655816000796 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 655816000797 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 655816000798 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 655816000799 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 655816000800 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 655816000801 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 655816000802 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 655816000803 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 655816000804 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 655816000805 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 655816000806 active site residue [active] 655816000807 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 655816000808 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 655816000809 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 655816000810 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655816000811 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 655816000812 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 655816000813 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816000814 active site turn [active] 655816000815 phosphorylation site [posttranslational modification] 655816000816 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 655816000817 HPr interaction site; other site 655816000818 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655816000819 active site 655816000820 phosphorylation site [posttranslational modification] 655816000821 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655816000822 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 655816000823 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 655816000824 active site 655816000825 trimer interface [polypeptide binding]; other site 655816000826 allosteric site; other site 655816000827 active site lid [active] 655816000828 hexamer (dimer of trimers) interface [polypeptide binding]; other site 655816000829 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 655816000830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816000831 DNA-binding site [nucleotide binding]; DNA binding site 655816000832 UTRA domain; Region: UTRA; pfam07702 655816000833 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 655816000834 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 655816000835 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 655816000836 homodimer interface [polypeptide binding]; other site 655816000837 substrate-cofactor binding pocket; other site 655816000838 catalytic residue [active] 655816000839 S-methylmethionine transporter; Provisional; Region: PRK11387 655816000840 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 655816000841 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 655816000842 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 655816000843 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 655816000844 glutaminase; Reviewed; Region: PRK12357 655816000845 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 655816000846 Chorismate mutase type II; Region: CM_2; cl00693 655816000847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816000848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816000849 ATP binding site [chemical binding]; other site 655816000850 Mg2+ binding site [ion binding]; other site 655816000851 G-X-G motif; other site 655816000852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816000853 Response regulator receiver domain; Region: Response_reg; pfam00072 655816000854 active site 655816000855 phosphorylation site [posttranslational modification] 655816000856 intermolecular recognition site; other site 655816000857 dimerization interface [polypeptide binding]; other site 655816000858 YcbB domain; Region: YcbB; pfam08664 655816000859 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 655816000860 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 655816000861 putative active site [active] 655816000862 catalytic residue [active] 655816000863 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 655816000864 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655816000865 NAD(P) binding site [chemical binding]; other site 655816000866 catalytic residues [active] 655816000867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000868 D-galactonate transporter; Region: 2A0114; TIGR00893 655816000869 putative substrate translocation pore; other site 655816000870 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 655816000871 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 655816000872 active site 655816000873 tetramer interface [polypeptide binding]; other site 655816000874 Transcriptional regulators [Transcription]; Region: FadR; COG2186 655816000875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816000876 DNA-binding site [nucleotide binding]; DNA binding site 655816000877 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 655816000878 galactarate dehydratase; Region: galactar-dH20; TIGR03248 655816000879 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 655816000880 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 655816000881 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 655816000882 putative active site [active] 655816000883 putative substrate binding site [chemical binding]; other site 655816000884 Phosphotransferase enzyme family; Region: APH; pfam01636 655816000885 ATP binding site [chemical binding]; other site 655816000886 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816000887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816000888 active site 655816000889 phosphorylation site [posttranslational modification] 655816000890 intermolecular recognition site; other site 655816000891 dimerization interface [polypeptide binding]; other site 655816000892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816000893 DNA binding site [nucleotide binding] 655816000894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816000895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816000896 dimer interface [polypeptide binding]; other site 655816000897 phosphorylation site [posttranslational modification] 655816000898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816000899 ATP binding site [chemical binding]; other site 655816000900 Mg2+ binding site [ion binding]; other site 655816000901 G-X-G motif; other site 655816000902 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816000903 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 655816000904 Walker A/P-loop; other site 655816000905 ATP binding site [chemical binding]; other site 655816000906 Q-loop/lid; other site 655816000907 ABC transporter signature motif; other site 655816000908 Walker B; other site 655816000909 D-loop; other site 655816000910 H-loop/switch region; other site 655816000911 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 655816000912 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 655816000913 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 655816000914 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 655816000915 reactive center loop; other site 655816000916 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 655816000917 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 655816000918 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 655816000919 metal ion-dependent adhesion site (MIDAS); other site 655816000920 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 655816000921 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 655816000922 putative active site [active] 655816000923 putative metal binding site [ion binding]; other site 655816000924 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 655816000925 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 655816000926 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 655816000927 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 655816000928 putative substrate binding pocket [chemical binding]; other site 655816000929 AC domain interface; other site 655816000930 catalytic triad [active] 655816000931 AB domain interface; other site 655816000932 interchain disulfide; other site 655816000933 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 655816000934 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 655816000935 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816000936 catalytic residue [active] 655816000937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000938 putative transporter; Provisional; Region: PRK10504 655816000939 putative substrate translocation pore; other site 655816000940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816000941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816000942 Lipase (class 2); Region: Lipase_2; pfam01674 655816000943 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816000944 Predicted membrane protein/domain [Function unknown]; Region: COG1714 655816000945 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 655816000946 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 655816000947 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 655816000948 ATP binding site [chemical binding]; other site 655816000949 G-X-G motif; other site 655816000950 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 655816000951 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816000952 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655816000953 active site 655816000954 catalytic tetrad [active] 655816000955 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 655816000956 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 655816000957 Homeodomain-like domain; Region: HTH_23; pfam13384 655816000958 putative transposase OrfB; Reviewed; Region: PHA02517 655816000959 HTH-like domain; Region: HTH_21; pfam13276 655816000960 Integrase core domain; Region: rve; pfam00665 655816000961 Integrase core domain; Region: rve_3; pfam13683 655816000962 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 655816000963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816000964 binding surface 655816000965 TPR motif; other site 655816000966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 655816000967 binding surface 655816000968 TPR motif; other site 655816000969 glucose-1-dehydrogenase; Provisional; Region: PRK08936 655816000970 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 655816000971 NAD binding site [chemical binding]; other site 655816000972 homodimer interface [polypeptide binding]; other site 655816000973 active site 655816000974 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 655816000975 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 655816000976 Ca binding site [ion binding]; other site 655816000977 active site 655816000978 catalytic site [active] 655816000979 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 655816000980 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 655816000981 metal binding site [ion binding]; metal-binding site 655816000982 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 655816000983 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 655816000984 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 655816000985 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816000986 ABC-ATPase subunit interface; other site 655816000987 dimer interface [polypeptide binding]; other site 655816000988 putative PBP binding regions; other site 655816000989 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 655816000990 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 655816000991 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 655816000992 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 655816000993 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 655816000994 putative metal binding site [ion binding]; other site 655816000995 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 655816000996 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 655816000997 putative metal binding site [ion binding]; other site 655816000998 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 655816000999 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 655816001000 putative metal binding site [ion binding]; other site 655816001001 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 655816001002 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 655816001003 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 655816001004 benzoate transport; Region: 2A0115; TIGR00895 655816001005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001006 putative substrate translocation pore; other site 655816001007 Helix-turn-helix domain; Region: HTH_20; pfam12840 655816001008 putative DNA binding site [nucleotide binding]; other site 655816001009 putative Zn2+ binding site [ion binding]; other site 655816001010 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 655816001011 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 655816001012 Walker A/P-loop; other site 655816001013 ATP binding site [chemical binding]; other site 655816001014 Q-loop/lid; other site 655816001015 ABC transporter signature motif; other site 655816001016 Walker B; other site 655816001017 D-loop; other site 655816001018 H-loop/switch region; other site 655816001019 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 655816001020 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 655816001021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816001022 dimer interface [polypeptide binding]; other site 655816001023 conserved gate region; other site 655816001024 putative PBP binding loops; other site 655816001025 ABC-ATPase subunit interface; other site 655816001026 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 655816001027 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 655816001028 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 655816001029 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 655816001030 amidohydrolase; Region: amidohydrolases; TIGR01891 655816001031 metal binding site [ion binding]; metal-binding site 655816001032 putative dimer interface [polypeptide binding]; other site 655816001033 Predicted membrane protein [Function unknown]; Region: COG1288 655816001034 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 655816001035 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 655816001036 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 655816001037 active site 655816001038 Ca binding site [ion binding]; other site 655816001039 catalytic site [active] 655816001040 Aamy_C domain; Region: Aamy_C; smart00632 655816001041 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 655816001042 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 655816001043 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816001044 NAD binding site [chemical binding]; other site 655816001045 dimer interface [polypeptide binding]; other site 655816001046 substrate binding site [chemical binding]; other site 655816001047 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 655816001048 L-lactate permease; Region: Lactate_perm; pfam02652 655816001049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001050 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816001051 putative substrate translocation pore; other site 655816001052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001053 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816001054 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816001055 putative Zn2+ binding site [ion binding]; other site 655816001056 putative DNA binding site [nucleotide binding]; other site 655816001057 dimerization interface [polypeptide binding]; other site 655816001058 LysE type translocator; Region: LysE; pfam01810 655816001059 Uncharacterized conserved protein [Function unknown]; Region: COG3403 655816001060 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 655816001061 Spore germination protein; Region: Spore_permease; cl17796 655816001062 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 655816001063 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 655816001064 NAD+ synthetase; Region: nadE; TIGR00552 655816001065 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 655816001066 homodimer interface [polypeptide binding]; other site 655816001067 NAD binding pocket [chemical binding]; other site 655816001068 ATP binding pocket [chemical binding]; other site 655816001069 Mg binding site [ion binding]; other site 655816001070 active-site loop [active] 655816001071 AAA domain; Region: AAA_18; pfam13238 655816001072 shikimate kinase; Reviewed; Region: aroK; PRK00131 655816001073 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 655816001074 ADP binding site [chemical binding]; other site 655816001075 magnesium binding site [ion binding]; other site 655816001076 putative shikimate binding site; other site 655816001077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816001078 S-adenosylmethionine binding site [chemical binding]; other site 655816001079 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816001080 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816001081 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655816001082 dimerization interface [polypeptide binding]; other site 655816001083 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 655816001084 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 655816001085 Proline dehydrogenase; Region: Pro_dh; pfam01619 655816001086 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 655816001087 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 655816001088 Glutamate binding site [chemical binding]; other site 655816001089 homodimer interface [polypeptide binding]; other site 655816001090 NAD binding site [chemical binding]; other site 655816001091 catalytic residues [active] 655816001092 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 655816001093 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 655816001094 Na binding site [ion binding]; other site 655816001095 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 655816001096 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 655816001097 Predicted membrane protein [Function unknown]; Region: COG3689 655816001098 Predicted permeases [General function prediction only]; Region: COG0701 655816001099 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 655816001100 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 655816001101 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655816001102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816001103 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 655816001104 active site 655816001105 SAM binding site [chemical binding]; other site 655816001106 homodimer interface [polypeptide binding]; other site 655816001107 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 655816001108 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 655816001109 active site 655816001110 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 655816001111 [2Fe-2S] cluster binding site [ion binding]; other site 655816001112 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 655816001113 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816001114 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 655816001115 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 655816001116 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 655816001117 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 655816001118 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 655816001119 [4Fe-4S] binding site [ion binding]; other site 655816001120 molybdopterin cofactor binding site; other site 655816001121 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 655816001122 molybdopterin cofactor binding site; other site 655816001123 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 655816001124 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655816001125 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816001126 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 655816001127 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 655816001128 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 655816001129 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 655816001130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001131 putative substrate translocation pore; other site 655816001132 putative GTP cyclohydrolase; Provisional; Region: PRK13674 655816001133 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 655816001134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 655816001135 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 655816001136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655816001137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816001138 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 655816001139 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 655816001140 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 655816001141 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 655816001142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816001143 dimer interface [polypeptide binding]; other site 655816001144 conserved gate region; other site 655816001145 putative PBP binding loops; other site 655816001146 ABC-ATPase subunit interface; other site 655816001147 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 655816001148 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655816001149 substrate binding pocket [chemical binding]; other site 655816001150 membrane-bound complex binding site; other site 655816001151 hinge residues; other site 655816001152 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 655816001153 RDD family; Region: RDD; pfam06271 655816001154 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 655816001155 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816001156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816001157 putative DNA binding site [nucleotide binding]; other site 655816001158 putative Zn2+ binding site [ion binding]; other site 655816001159 hypothetical protein; Provisional; Region: PRK09272 655816001160 Predicted ATPase [General function prediction only]; Region: COG3910 655816001161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 655816001162 Walker A/P-loop; other site 655816001163 ATP binding site [chemical binding]; other site 655816001164 Q-loop/lid; other site 655816001165 ABC transporter signature motif; other site 655816001166 Walker B; other site 655816001167 D-loop; other site 655816001168 H-loop/switch region; other site 655816001169 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 655816001170 beta-galactosidase; Region: BGL; TIGR03356 655816001171 Competence protein J (ComJ); Region: ComJ; pfam11033 655816001172 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 655816001173 HAMP domain; Region: HAMP; pfam00672 655816001174 dimerization interface [polypeptide binding]; other site 655816001175 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816001176 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816001177 dimer interface [polypeptide binding]; other site 655816001178 putative CheW interface [polypeptide binding]; other site 655816001179 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 655816001180 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 655816001181 tetramer interface [polypeptide binding]; other site 655816001182 active site 655816001183 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 655816001184 active site 655816001185 dimer interface [polypeptide binding]; other site 655816001186 magnesium binding site [ion binding]; other site 655816001187 Predicted transcriptional regulators [Transcription]; Region: COG1733 655816001188 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 655816001189 Condensation domain; Region: Condensation; pfam00668 655816001190 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816001191 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816001192 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655816001193 acyl-activating enzyme (AAE) consensus motif; other site 655816001194 AMP binding site [chemical binding]; other site 655816001195 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816001196 Condensation domain; Region: Condensation; pfam00668 655816001197 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816001198 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816001199 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 655816001200 acyl-activating enzyme (AAE) consensus motif; other site 655816001201 AMP binding site [chemical binding]; other site 655816001202 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816001203 Condensation domain; Region: Condensation; pfam00668 655816001204 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816001205 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816001206 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655816001207 acyl-activating enzyme (AAE) consensus motif; other site 655816001208 AMP binding site [chemical binding]; other site 655816001209 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816001210 Condensation domain; Region: Condensation; pfam00668 655816001211 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816001212 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 655816001213 Condensation domain; Region: Condensation; pfam00668 655816001214 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816001215 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 655816001216 acyl-activating enzyme (AAE) consensus motif; other site 655816001217 AMP binding site [chemical binding]; other site 655816001218 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816001219 Condensation domain; Region: Condensation; pfam00668 655816001220 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816001221 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816001222 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655816001223 acyl-activating enzyme (AAE) consensus motif; other site 655816001224 AMP binding site [chemical binding]; other site 655816001225 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816001226 Condensation domain; Region: Condensation; pfam00668 655816001227 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816001228 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816001229 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655816001230 acyl-activating enzyme (AAE) consensus motif; other site 655816001231 AMP binding site [chemical binding]; other site 655816001232 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816001233 Condensation domain; Region: Condensation; pfam00668 655816001234 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 655816001235 Condensation domain; Region: Condensation; pfam00668 655816001236 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816001237 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 655816001238 acyl-activating enzyme (AAE) consensus motif; other site 655816001239 AMP binding site [chemical binding]; other site 655816001240 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816001241 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 655816001242 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 655816001243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816001245 putative substrate translocation pore; other site 655816001246 YcxB-like protein; Region: YcxB; pfam14317 655816001247 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 655816001248 EamA-like transporter family; Region: EamA; pfam00892 655816001249 EamA-like transporter family; Region: EamA; pfam00892 655816001250 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816001251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001252 DNA-binding site [nucleotide binding]; DNA binding site 655816001253 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816001254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816001255 homodimer interface [polypeptide binding]; other site 655816001256 catalytic residue [active] 655816001257 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 655816001258 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 655816001259 Predicted membrane protein [Function unknown]; Region: COG2364 655816001260 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 655816001261 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 655816001262 Walker A/P-loop; other site 655816001263 ATP binding site [chemical binding]; other site 655816001264 Q-loop/lid; other site 655816001265 ABC transporter signature motif; other site 655816001266 Walker B; other site 655816001267 D-loop; other site 655816001268 H-loop/switch region; other site 655816001269 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 655816001270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816001271 dimer interface [polypeptide binding]; other site 655816001272 conserved gate region; other site 655816001273 putative PBP binding loops; other site 655816001274 ABC-ATPase subunit interface; other site 655816001275 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 655816001276 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655816001277 substrate binding pocket [chemical binding]; other site 655816001278 membrane-bound complex binding site; other site 655816001279 hinge residues; other site 655816001280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816001281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816001282 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655816001283 dimerization interface [polypeptide binding]; other site 655816001284 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 655816001285 Flavoprotein; Region: Flavoprotein; pfam02441 655816001286 UbiD family decarboxylase; Region: TIGR00148 655816001287 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 655816001288 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 655816001289 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 655816001290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001291 putative substrate translocation pore; other site 655816001292 POT family; Region: PTR2; pfam00854 655816001293 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 655816001294 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 655816001295 Right handed beta helix region; Region: Beta_helix; pfam13229 655816001296 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 655816001297 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 655816001298 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 655816001299 Spore germination protein; Region: Spore_permease; pfam03845 655816001300 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816001301 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 655816001302 Walker A/P-loop; other site 655816001303 ATP binding site [chemical binding]; other site 655816001304 Q-loop/lid; other site 655816001305 ABC transporter signature motif; other site 655816001306 Walker B; other site 655816001307 D-loop; other site 655816001308 H-loop/switch region; other site 655816001309 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 655816001310 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 655816001311 FtsX-like permease family; Region: FtsX; pfam02687 655816001312 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816001313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816001314 active site 655816001315 phosphorylation site [posttranslational modification] 655816001316 intermolecular recognition site; other site 655816001317 dimerization interface [polypeptide binding]; other site 655816001318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816001319 DNA binding site [nucleotide binding] 655816001320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816001321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816001322 dimerization interface [polypeptide binding]; other site 655816001323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816001324 dimer interface [polypeptide binding]; other site 655816001325 phosphorylation site [posttranslational modification] 655816001326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816001327 ATP binding site [chemical binding]; other site 655816001328 Mg2+ binding site [ion binding]; other site 655816001329 G-X-G motif; other site 655816001330 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816001331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816001332 TPR motif; other site 655816001333 binding surface 655816001334 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816001335 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 655816001336 aspartate kinase; Reviewed; Region: PRK09034 655816001337 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 655816001338 putative catalytic residues [active] 655816001339 putative nucleotide binding site [chemical binding]; other site 655816001340 putative aspartate binding site [chemical binding]; other site 655816001341 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 655816001342 allosteric regulatory residue; other site 655816001343 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 655816001344 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 655816001345 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816001346 ABC-ATPase subunit interface; other site 655816001347 dimer interface [polypeptide binding]; other site 655816001348 putative PBP binding regions; other site 655816001349 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655816001350 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816001351 ABC-ATPase subunit interface; other site 655816001352 dimer interface [polypeptide binding]; other site 655816001353 putative PBP binding regions; other site 655816001354 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 655816001355 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655816001356 Walker A/P-loop; other site 655816001357 ATP binding site [chemical binding]; other site 655816001358 Q-loop/lid; other site 655816001359 ABC transporter signature motif; other site 655816001360 Walker B; other site 655816001361 D-loop; other site 655816001362 H-loop/switch region; other site 655816001363 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 655816001364 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 655816001365 putative ligand binding residues [chemical binding]; other site 655816001366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816001368 putative substrate translocation pore; other site 655816001369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001370 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816001371 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816001372 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 655816001373 dimer interface [polypeptide binding]; other site 655816001374 FMN binding site [chemical binding]; other site 655816001375 NADPH bind site [chemical binding]; other site 655816001376 Uncharacterized conserved protein [Function unknown]; Region: COG1359 655816001377 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816001378 dimerization interface [polypeptide binding]; other site 655816001379 putative DNA binding site [nucleotide binding]; other site 655816001380 putative Zn2+ binding site [ion binding]; other site 655816001381 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816001382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001383 DNA-binding site [nucleotide binding]; DNA binding site 655816001384 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816001385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816001386 homodimer interface [polypeptide binding]; other site 655816001387 catalytic residue [active] 655816001388 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 655816001389 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816001390 inhibitor-cofactor binding pocket; inhibition site 655816001391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816001392 catalytic residue [active] 655816001393 succinic semialdehyde dehydrogenase; Region: PLN02278 655816001394 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 655816001395 tetramerization interface [polypeptide binding]; other site 655816001396 NAD(P) binding site [chemical binding]; other site 655816001397 catalytic residues [active] 655816001398 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 655816001399 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 655816001400 glucose-1-dehydrogenase; Provisional; Region: PRK08936 655816001401 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 655816001402 NAD binding site [chemical binding]; other site 655816001403 homodimer interface [polypeptide binding]; other site 655816001404 active site 655816001405 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 655816001406 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 655816001407 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 655816001408 YtkA-like; Region: YtkA; pfam13115 655816001409 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655816001410 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 655816001411 NosL; Region: NosL; cl01769 655816001412 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 655816001413 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 655816001414 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 655816001415 active site 655816001416 P-loop; other site 655816001417 phosphorylation site [posttranslational modification] 655816001418 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655816001419 active site 655816001420 phosphorylation site [posttranslational modification] 655816001421 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 655816001422 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 655816001423 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 655816001424 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 655816001425 tartrate dehydrogenase; Provisional; Region: PRK08194 655816001426 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 655816001427 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 655816001428 Catalytic site [active] 655816001429 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 655816001430 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 655816001431 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 655816001432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816001433 active site 655816001434 motif I; other site 655816001435 motif II; other site 655816001436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816001437 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 655816001438 putative active site [active] 655816001439 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 655816001440 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 655816001441 hypothetical protein; Provisional; Region: PRK05463 655816001442 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 655816001443 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 655816001444 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 655816001445 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 655816001446 Transcriptional regulator [Transcription]; Region: IclR; COG1414 655816001447 Bacterial transcriptional regulator; Region: IclR; pfam01614 655816001448 Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755 655816001449 active site 655816001450 catalytic triad [active] 655816001451 oxyanion hole [active] 655816001452 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 655816001453 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 655816001454 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 655816001455 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 655816001456 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816001457 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 655816001458 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816001459 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655816001460 active site 655816001461 catalytic tetrad [active] 655816001462 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 655816001463 HTH domain; Region: HTH_11; pfam08279 655816001464 PRD domain; Region: PRD; pfam00874 655816001465 PRD domain; Region: PRD; pfam00874 655816001466 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 655816001467 active site 655816001468 P-loop; other site 655816001469 phosphorylation site [posttranslational modification] 655816001470 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 655816001471 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 655816001472 acyl-activating enzyme (AAE) consensus motif; other site 655816001473 putative AMP binding site [chemical binding]; other site 655816001474 putative active site [active] 655816001475 putative CoA binding site [chemical binding]; other site 655816001476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816001477 S-adenosylmethionine binding site [chemical binding]; other site 655816001478 short chain dehydrogenase; Provisional; Region: PRK06701 655816001479 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 655816001480 NAD binding site [chemical binding]; other site 655816001481 metal binding site [ion binding]; metal-binding site 655816001482 active site 655816001483 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 655816001484 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 655816001485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 655816001486 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 655816001487 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 655816001488 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 655816001489 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 655816001490 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 655816001491 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 655816001492 putative DNA binding site [nucleotide binding]; other site 655816001493 putative Zn2+ binding site [ion binding]; other site 655816001494 AsnC family; Region: AsnC_trans_reg; pfam01037 655816001495 DNA topoisomerase III; Provisional; Region: PRK07726 655816001496 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 655816001497 active site 655816001498 putative interdomain interaction site [polypeptide binding]; other site 655816001499 putative metal-binding site [ion binding]; other site 655816001500 putative nucleotide binding site [chemical binding]; other site 655816001501 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 655816001502 domain I; other site 655816001503 DNA binding groove [nucleotide binding] 655816001504 phosphate binding site [ion binding]; other site 655816001505 domain II; other site 655816001506 domain III; other site 655816001507 nucleotide binding site [chemical binding]; other site 655816001508 catalytic site [active] 655816001509 domain IV; other site 655816001510 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 655816001511 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 655816001512 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 655816001513 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 655816001514 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655816001515 metal binding site [ion binding]; metal-binding site 655816001516 active site 655816001517 I-site; other site 655816001518 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 655816001519 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 655816001520 NodB motif; other site 655816001521 putative active site [active] 655816001522 putative catalytic site [active] 655816001523 putative Zn binding site [ion binding]; other site 655816001524 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 655816001525 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 655816001526 DXD motif; other site 655816001527 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 655816001528 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 655816001529 ydaO riboswitch leader; may be triggered during osmotic shock, leading to expression of ydaO; the natural ligand has not been determined; BSUW23_misc_RNA_7 655816001530 Amino acid permease; Region: AA_permease_2; pfam13520 655816001531 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 655816001532 nudix motif; other site 655816001533 pyruvate oxidase; Provisional; Region: PRK08611 655816001534 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 655816001535 PYR/PP interface [polypeptide binding]; other site 655816001536 tetramer interface [polypeptide binding]; other site 655816001537 dimer interface [polypeptide binding]; other site 655816001538 TPP binding site [chemical binding]; other site 655816001539 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 655816001540 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 655816001541 TPP-binding site [chemical binding]; other site 655816001542 manganese transport protein MntH; Reviewed; Region: PRK00701 655816001543 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 655816001544 Predicted membrane protein [Function unknown]; Region: COG2261 655816001545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 655816001546 EcsC protein family; Region: EcsC; pfam12787 655816001547 General stress protein [General function prediction only]; Region: GsiB; COG3729 655816001548 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 655816001549 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 655816001550 dimanganese center [ion binding]; other site 655816001551 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 655816001552 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 655816001553 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 655816001554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816001555 putative active site [active] 655816001556 heme pocket [chemical binding]; other site 655816001557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816001558 ATP binding site [chemical binding]; other site 655816001559 Mg2+ binding site [ion binding]; other site 655816001560 G-X-G motif; other site 655816001561 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 655816001562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816001563 active site 655816001564 phosphorylation site [posttranslational modification] 655816001565 intermolecular recognition site; other site 655816001566 dimerization interface [polypeptide binding]; other site 655816001567 HTH domain; Region: HTH_11; cl17392 655816001568 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 655816001569 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 655816001570 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 655816001571 Domain of unknown function DUF20; Region: UPF0118; pfam01594 655816001572 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 655816001573 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 655816001574 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816001575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655816001576 Walker A/P-loop; other site 655816001577 ATP binding site [chemical binding]; other site 655816001578 Q-loop/lid; other site 655816001579 ABC transporter signature motif; other site 655816001580 Walker B; other site 655816001581 D-loop; other site 655816001582 H-loop/switch region; other site 655816001583 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 655816001584 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 655816001585 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 655816001586 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 655816001587 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 655816001588 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 655816001589 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 655816001590 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 655816001591 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 655816001592 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 655816001593 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 655816001594 catalytic residues [active] 655816001595 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 655816001596 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 655816001597 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 655816001598 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 655816001599 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 655816001600 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655816001601 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655816001602 helicase 45; Provisional; Region: PTZ00424 655816001603 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 655816001604 ATP binding site [chemical binding]; other site 655816001605 Mg++ binding site [ion binding]; other site 655816001606 motif III; other site 655816001607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816001608 nucleotide binding region [chemical binding]; other site 655816001609 ATP-binding site [chemical binding]; other site 655816001610 Uncharacterized conserved protein [Function unknown]; Region: COG3402 655816001611 Predicted membrane protein [Function unknown]; Region: COG3428 655816001612 Bacterial PH domain; Region: DUF304; pfam03703 655816001613 Bacterial PH domain; Region: DUF304; pfam03703 655816001614 Bacterial PH domain; Region: DUF304; pfam03703 655816001615 Rhomboid family; Region: Rhomboid; pfam01694 655816001616 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 655816001617 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 655816001618 alanine racemase; Region: alr; TIGR00492 655816001619 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 655816001620 active site 655816001621 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655816001622 dimer interface [polypeptide binding]; other site 655816001623 substrate binding site [chemical binding]; other site 655816001624 catalytic residues [active] 655816001625 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 655816001626 ribbon-helix-helix domain containing protein; Region: PHA00617 655816001627 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 655816001628 Rsbr N terminal; Region: Rsbr_N; pfam08678 655816001629 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816001630 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816001631 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 655816001632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816001633 ATP binding site [chemical binding]; other site 655816001634 Mg2+ binding site [ion binding]; other site 655816001635 G-X-G motif; other site 655816001636 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 655816001637 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 655816001638 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 655816001639 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 655816001640 anti sigma factor interaction site; other site 655816001641 regulatory phosphorylation site [posttranslational modification]; other site 655816001642 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 655816001643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816001644 ATP binding site [chemical binding]; other site 655816001645 Mg2+ binding site [ion binding]; other site 655816001646 G-X-G motif; other site 655816001647 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 655816001648 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816001649 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 655816001650 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816001651 DNA binding residues [nucleotide binding] 655816001652 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 655816001653 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 655816001654 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 655816001655 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 655816001656 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 655816001657 RNA binding site [nucleotide binding]; other site 655816001658 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 655816001659 hypothetical protein; Provisional; Region: PRK04351 655816001660 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 655816001661 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 655816001662 DNA binding residues [nucleotide binding] 655816001663 putative dimer interface [polypeptide binding]; other site 655816001664 short chain dehydrogenase; Provisional; Region: PRK06180 655816001665 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 655816001666 NADP binding site [chemical binding]; other site 655816001667 active site 655816001668 steroid binding site; other site 655816001669 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816001670 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655816001671 active site 655816001672 catalytic tetrad [active] 655816001673 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 655816001674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816001675 NAD(P) binding site [chemical binding]; other site 655816001676 active site 655816001677 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 655816001678 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 655816001679 NADP binding site [chemical binding]; other site 655816001680 substrate binding site [chemical binding]; other site 655816001681 active site 655816001682 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 655816001683 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 655816001684 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 655816001685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816001686 NAD(P) binding site [chemical binding]; other site 655816001687 active site 655816001688 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 655816001689 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 655816001690 putative di-iron ligands [ion binding]; other site 655816001691 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 655816001692 DNA-binding site [nucleotide binding]; DNA binding site 655816001693 RNA-binding motif; other site 655816001694 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 655816001695 EamA-like transporter family; Region: EamA; cl17759 655816001696 EamA-like transporter family; Region: EamA; pfam00892 655816001697 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 655816001698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816001699 non-specific DNA binding site [nucleotide binding]; other site 655816001700 salt bridge; other site 655816001701 sequence-specific DNA binding site [nucleotide binding]; other site 655816001702 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816001703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 655816001704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 655816001705 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 655816001706 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 655816001707 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 655816001708 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 655816001709 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 655816001710 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 655816001711 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 655816001712 putative DNA binding site [nucleotide binding]; other site 655816001713 putative Zn2+ binding site [ion binding]; other site 655816001714 AsnC family; Region: AsnC_trans_reg; pfam01037 655816001715 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 655816001716 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816001717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001718 DNA-binding site [nucleotide binding]; DNA binding site 655816001719 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816001720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816001721 homodimer interface [polypeptide binding]; other site 655816001722 catalytic residue [active] 655816001723 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 655816001724 putative active site [active] 655816001725 putative catalytic site [active] 655816001726 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 655816001727 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816001728 Predicted transcriptional regulators [Transcription]; Region: COG1733 655816001729 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 655816001730 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816001731 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816001732 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816001733 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 655816001734 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 655816001735 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816001736 dimerization interface [polypeptide binding]; other site 655816001737 putative DNA binding site [nucleotide binding]; other site 655816001738 putative Zn2+ binding site [ion binding]; other site 655816001739 arsenical pump membrane protein; Provisional; Region: PRK15445 655816001740 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 655816001741 transmembrane helices; other site 655816001742 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 655816001743 Low molecular weight phosphatase family; Region: LMWPc; cd00115 655816001744 active site 655816001745 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 655816001746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816001747 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 655816001748 EamA-like transporter family; Region: EamA; pfam00892 655816001749 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 655816001750 EamA-like transporter family; Region: EamA; pfam00892 655816001751 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816001752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001753 DNA-binding site [nucleotide binding]; DNA binding site 655816001754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816001755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816001756 homodimer interface [polypeptide binding]; other site 655816001757 catalytic residue [active] 655816001758 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 655816001759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816001760 putative Zn2+ binding site [ion binding]; other site 655816001761 putative DNA binding site [nucleotide binding]; other site 655816001762 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 655816001763 Uncharacterized conserved protein [Function unknown]; Region: COG2128 655816001764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816001765 Histidine kinase; Region: HisKA_3; pfam07730 655816001766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816001767 ATP binding site [chemical binding]; other site 655816001768 Mg2+ binding site [ion binding]; other site 655816001769 G-X-G motif; other site 655816001770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816001771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816001772 active site 655816001773 phosphorylation site [posttranslational modification] 655816001774 intermolecular recognition site; other site 655816001775 dimerization interface [polypeptide binding]; other site 655816001776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816001777 DNA binding residues [nucleotide binding] 655816001778 dimerization interface [polypeptide binding]; other site 655816001779 MMPL family; Region: MMPL; pfam03176 655816001780 MMPL family; Region: MMPL; pfam03176 655816001781 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 655816001782 AzlC protein; Region: AzlC; cl00570 655816001783 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 655816001784 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 655816001785 Protein of unknown function (DUF554); Region: DUF554; pfam04474 655816001786 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 655816001787 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 655816001788 DNA binding residues [nucleotide binding] 655816001789 drug binding residues [chemical binding]; other site 655816001790 dimer interface [polypeptide binding]; other site 655816001791 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 655816001792 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 655816001793 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 655816001794 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 655816001795 dimer interface [polypeptide binding]; other site 655816001796 FMN binding site [chemical binding]; other site 655816001797 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 655816001798 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816001799 Zn binding site [ion binding]; other site 655816001800 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 655816001801 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816001802 Zn binding site [ion binding]; other site 655816001803 Predicted membrane protein [Function unknown]; Region: COG2259 655816001804 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 655816001805 catalytic residues [active] 655816001806 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816001807 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001808 DNA-binding site [nucleotide binding]; DNA binding site 655816001809 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816001810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816001811 homodimer interface [polypeptide binding]; other site 655816001812 catalytic residue [active] 655816001813 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 655816001814 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 655816001815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 655816001816 Protein of unknown function (DUF421); Region: DUF421; cl00990 655816001817 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 655816001818 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 655816001819 putative dimer interface [polypeptide binding]; other site 655816001820 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 655816001821 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 655816001822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816001823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816001824 DoxX-like family; Region: DoxX_2; pfam13564 655816001825 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816001826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816001827 Coenzyme A binding pocket [chemical binding]; other site 655816001828 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 655816001829 nucleotide binding site/active site [active] 655816001830 HIT family signature motif; other site 655816001831 catalytic residue [active] 655816001832 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816001833 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655816001834 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 655816001835 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816001836 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816001837 DNA binding site [nucleotide binding] 655816001838 domain linker motif; other site 655816001839 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 655816001840 dimerization interface [polypeptide binding]; other site 655816001841 ligand binding site [chemical binding]; other site 655816001842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001843 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 655816001844 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 655816001845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001846 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816001847 putative substrate translocation pore; other site 655816001848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816001849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816001850 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 655816001851 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655816001852 ABC transporter; Region: ABC_tran_2; pfam12848 655816001853 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655816001854 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 655816001855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 655816001856 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816001857 MarR family; Region: MarR; pfam01047 655816001858 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 655816001859 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 655816001860 dimer interface [polypeptide binding]; other site 655816001861 FMN binding site [chemical binding]; other site 655816001862 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816001863 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816001864 putative DNA binding site [nucleotide binding]; other site 655816001865 putative Zn2+ binding site [ion binding]; other site 655816001866 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 655816001867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816001868 non-specific DNA binding site [nucleotide binding]; other site 655816001869 salt bridge; other site 655816001870 sequence-specific DNA binding site [nucleotide binding]; other site 655816001871 Cupin domain; Region: Cupin_2; pfam07883 655816001872 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 655816001873 Predicted membrane protein [Function unknown]; Region: COG4392 655816001874 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 655816001875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001876 putative substrate translocation pore; other site 655816001877 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 655816001878 hypothetical protein; Provisional; Region: PRK10621 655816001879 Transcriptional regulators [Transcription]; Region: GntR; COG1802 655816001880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001881 DNA-binding site [nucleotide binding]; DNA binding site 655816001882 FCD domain; Region: FCD; pfam07729 655816001883 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 655816001884 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816001885 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816001886 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 655816001887 active site 655816001888 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 655816001889 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 655816001890 homodimer interface [polypeptide binding]; other site 655816001891 active site 655816001892 TDP-binding site; other site 655816001893 acceptor substrate-binding pocket; other site 655816001894 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 655816001895 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 655816001896 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 655816001897 dimer interface [polypeptide binding]; other site 655816001898 active site 655816001899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816001900 Coenzyme A binding pocket [chemical binding]; other site 655816001901 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 655816001902 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816001903 Zn2+ binding site [ion binding]; other site 655816001904 Mg2+ binding site [ion binding]; other site 655816001905 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 655816001906 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 655816001907 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 655816001908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001909 putative substrate translocation pore; other site 655816001910 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 655816001911 active site 655816001912 P-loop; other site 655816001913 phosphorylation site [posttranslational modification] 655816001914 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 655816001915 active site 655816001916 methionine cluster; other site 655816001917 phosphorylation site [posttranslational modification] 655816001918 metal binding site [ion binding]; metal-binding site 655816001919 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 655816001920 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 655816001921 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 655816001922 beta-galactosidase; Region: BGL; TIGR03356 655816001923 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 655816001924 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001925 DNA-binding site [nucleotide binding]; DNA binding site 655816001926 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 655816001927 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 655816001928 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655816001929 nucleotide binding site [chemical binding]; other site 655816001930 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 655816001931 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 655816001932 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 655816001933 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 655816001934 dimanganese center [ion binding]; other site 655816001935 thiamine-monophosphate kinase; Region: thiL; TIGR01379 655816001936 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 655816001937 ATP binding site [chemical binding]; other site 655816001938 dimerization interface [polypeptide binding]; other site 655816001939 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 655816001940 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 655816001941 Glycoprotease family; Region: Peptidase_M22; pfam00814 655816001942 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 655816001943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816001944 Coenzyme A binding pocket [chemical binding]; other site 655816001945 UGMP family protein; Validated; Region: PRK09604 655816001946 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 655816001947 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 655816001948 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655816001949 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655816001950 ABC transporter; Region: ABC_tran_2; pfam12848 655816001951 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655816001952 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 655816001953 trimer interface [polypeptide binding]; other site 655816001954 dimer interface [polypeptide binding]; other site 655816001955 putative active site [active] 655816001956 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 655816001957 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 655816001958 CoA binding domain; Region: CoA_binding; pfam02629 655816001959 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 655816001960 Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945 655816001961 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 655816001962 CAAX protease self-immunity; Region: Abi; pfam02517 655816001963 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 655816001964 oligomerisation interface [polypeptide binding]; other site 655816001965 mobile loop; other site 655816001966 roof hairpin; other site 655816001967 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 655816001968 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 655816001969 ring oligomerisation interface [polypeptide binding]; other site 655816001970 ATP/Mg binding site [chemical binding]; other site 655816001971 stacking interactions; other site 655816001972 hinge regions; other site 655816001973 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816001974 NB-ARC domain; Region: NB-ARC; pfam00931 655816001975 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816001976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816001977 TPR motif; other site 655816001978 TPR repeat; Region: TPR_11; pfam13414 655816001979 binding surface 655816001980 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655816001981 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 655816001982 inhibitor binding site; inhibition site 655816001983 catalytic Zn binding site [ion binding]; other site 655816001984 structural Zn binding site [ion binding]; other site 655816001985 NADP binding site [chemical binding]; other site 655816001986 tetramer interface [polypeptide binding]; other site 655816001987 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 655816001988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001989 putative substrate translocation pore; other site 655816001990 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655816001991 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 655816001992 putative substrate binding site [chemical binding]; other site 655816001993 putative ATP binding site [chemical binding]; other site 655816001994 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 655816001995 DNA-directed RNA polymerase subunit F; Provisional; Region: PRK14981 655816001996 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 655816001997 Repair protein; Region: Repair_PSII; pfam04536 655816001998 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 655816001999 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 655816002000 Double zinc ribbon; Region: DZR; pfam12773 655816002001 Ion channel; Region: Ion_trans_2; pfam07885 655816002002 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 655816002003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002004 putative substrate translocation pore; other site 655816002005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002006 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655816002007 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 655816002008 putative NAD(P) binding site [chemical binding]; other site 655816002009 catalytic Zn binding site [ion binding]; other site 655816002010 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 655816002011 Homeodomain-like domain; Region: HTH_23; pfam13384 655816002012 putative transposase OrfB; Reviewed; Region: PHA02517 655816002013 HTH-like domain; Region: HTH_21; pfam13276 655816002014 Integrase core domain; Region: rve; pfam00665 655816002015 Integrase core domain; Region: rve_3; pfam13683 655816002016 Cold-inducible protein YdjO; Region: YdjO; pfam14169 655816002017 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 655816002018 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 655816002019 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 655816002020 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 655816002021 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 655816002022 Multicopper oxidase; Region: Cu-oxidase; pfam00394 655816002023 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 655816002024 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 655816002025 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 655816002026 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 655816002027 MoxR-like ATPases [General function prediction only]; Region: COG0714 655816002028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816002029 Walker A motif; other site 655816002030 ATP binding site [chemical binding]; other site 655816002031 Walker B motif; other site 655816002032 arginine finger; other site 655816002033 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 655816002034 Protein of unknown function DUF58; Region: DUF58; pfam01882 655816002035 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 655816002036 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 655816002037 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 655816002038 GMP synthase; Reviewed; Region: guaA; PRK00074 655816002039 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 655816002040 AMP/PPi binding site [chemical binding]; other site 655816002041 candidate oxyanion hole; other site 655816002042 catalytic triad [active] 655816002043 potential glutamine specificity residues [chemical binding]; other site 655816002044 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 655816002045 ATP Binding subdomain [chemical binding]; other site 655816002046 Ligand Binding sites [chemical binding]; other site 655816002047 Dimerization subdomain; other site 655816002048 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 655816002049 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 655816002050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 655816002051 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 655816002052 NETI protein; Region: NETI; pfam14044 655816002053 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 655816002054 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 655816002055 ATP-grasp domain; Region: ATP-grasp; pfam02222 655816002056 adenylosuccinate lyase; Provisional; Region: PRK07492 655816002057 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 655816002058 tetramer interface [polypeptide binding]; other site 655816002059 active site 655816002060 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 655816002061 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 655816002062 ATP binding site [chemical binding]; other site 655816002063 active site 655816002064 substrate binding site [chemical binding]; other site 655816002065 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 655816002066 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 655816002067 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 655816002068 putative active site [active] 655816002069 catalytic triad [active] 655816002070 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 655816002071 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 655816002072 dimerization interface [polypeptide binding]; other site 655816002073 ATP binding site [chemical binding]; other site 655816002074 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 655816002075 dimerization interface [polypeptide binding]; other site 655816002076 ATP binding site [chemical binding]; other site 655816002077 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 655816002078 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 655816002079 active site 655816002080 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816002081 active site 655816002082 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 655816002083 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 655816002084 dimerization interface [polypeptide binding]; other site 655816002085 putative ATP binding site [chemical binding]; other site 655816002086 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 655816002087 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 655816002088 active site 655816002089 substrate binding site [chemical binding]; other site 655816002090 cosubstrate binding site; other site 655816002091 catalytic site [active] 655816002092 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 655816002093 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 655816002094 purine monophosphate binding site [chemical binding]; other site 655816002095 dimer interface [polypeptide binding]; other site 655816002096 putative catalytic residues [active] 655816002097 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 655816002098 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 655816002099 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 655816002100 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 655816002101 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 655816002102 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 655816002103 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 655816002104 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816002105 putative DNA binding site [nucleotide binding]; other site 655816002106 putative Zn2+ binding site [ion binding]; other site 655816002107 AsnC family; Region: AsnC_trans_reg; pfam01037 655816002108 putative transporter; Provisional; Region: PRK11021 655816002109 Spore germination protein; Region: Spore_permease; cl17796 655816002110 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 655816002111 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 655816002112 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 655816002113 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 655816002114 active site 655816002115 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 655816002116 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 655816002117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 655816002118 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 655816002119 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 655816002120 active site 655816002121 FMN binding site [chemical binding]; other site 655816002122 substrate binding site [chemical binding]; other site 655816002123 3Fe-4S cluster binding site [ion binding]; other site 655816002124 PcrB family; Region: PcrB; pfam01884 655816002125 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 655816002126 substrate binding site [chemical binding]; other site 655816002127 putative active site [active] 655816002128 dimer interface [polypeptide binding]; other site 655816002129 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 655816002130 Part of AAA domain; Region: AAA_19; pfam13245 655816002131 Family description; Region: UvrD_C_2; pfam13538 655816002132 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 655816002133 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 655816002134 nucleotide binding pocket [chemical binding]; other site 655816002135 K-X-D-G motif; other site 655816002136 catalytic site [active] 655816002137 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 655816002138 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 655816002139 Helix-hairpin-helix motif; Region: HHH; pfam00633 655816002140 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 655816002141 Dimer interface [polypeptide binding]; other site 655816002142 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 655816002143 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 655816002144 putative dimer interface [polypeptide binding]; other site 655816002145 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 655816002146 putative dimer interface [polypeptide binding]; other site 655816002147 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 655816002148 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 655816002149 active site 655816002150 ATP binding site [chemical binding]; other site 655816002151 substrate binding site [chemical binding]; other site 655816002152 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 655816002153 MgtC family; Region: MgtC; pfam02308 655816002154 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 655816002155 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 655816002156 Na binding site [ion binding]; other site 655816002157 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 655816002158 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 655816002159 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 655816002160 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 655816002161 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 655816002162 GatB domain; Region: GatB_Yqey; pfam02637 655816002163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816002164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816002165 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 655816002166 Protein export membrane protein; Region: SecD_SecF; cl14618 655816002167 putative lipid kinase; Reviewed; Region: PRK13337 655816002168 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 655816002169 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 655816002170 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 655816002171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816002172 S-adenosylmethionine binding site [chemical binding]; other site 655816002173 HsdM N-terminal domain; Region: HsdM_N; pfam12161 655816002174 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 655816002175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816002176 S-adenosylmethionine binding site [chemical binding]; other site 655816002177 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 655816002178 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 655816002179 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 655816002180 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816002181 ATP binding site [chemical binding]; other site 655816002182 putative Mg++ binding site [ion binding]; other site 655816002183 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 655816002184 Protein of unknown function, DUF600; Region: DUF600; pfam04634 655816002185 Protein of unknown function, DUF600; Region: DUF600; pfam04634 655816002186 Uncharacterized conserved protein [Function unknown]; Region: COG5444 655816002187 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 655816002188 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816002189 hypothetical protein; Provisional; Region: PRK12378 655816002190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816002191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816002192 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 655816002193 reactive center loop; other site 655816002194 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 655816002195 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 655816002196 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 655816002197 NADP binding site [chemical binding]; other site 655816002198 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 655816002199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816002200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816002201 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 655816002202 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 655816002203 CotJB protein; Region: CotJB; pfam12652 655816002204 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 655816002205 dimanganese center [ion binding]; other site 655816002206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816002207 Coenzyme A binding pocket [chemical binding]; other site 655816002208 YesK-like protein; Region: YesK; pfam14150 655816002209 Predicted integral membrane protein [Function unknown]; Region: COG5578 655816002210 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 655816002211 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816002212 dimerization interface [polypeptide binding]; other site 655816002213 Histidine kinase; Region: His_kinase; pfam06580 655816002214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816002215 ATP binding site [chemical binding]; other site 655816002216 Mg2+ binding site [ion binding]; other site 655816002217 G-X-G motif; other site 655816002218 Response regulator receiver domain; Region: Response_reg; pfam00072 655816002219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816002220 active site 655816002221 phosphorylation site [posttranslational modification] 655816002222 intermolecular recognition site; other site 655816002223 dimerization interface [polypeptide binding]; other site 655816002224 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816002225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816002226 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 655816002227 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 655816002228 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 655816002229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816002230 dimer interface [polypeptide binding]; other site 655816002231 conserved gate region; other site 655816002232 putative PBP binding loops; other site 655816002233 ABC-ATPase subunit interface; other site 655816002234 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655816002235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816002236 dimer interface [polypeptide binding]; other site 655816002237 conserved gate region; other site 655816002238 putative PBP binding loops; other site 655816002239 ABC-ATPase subunit interface; other site 655816002240 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 655816002241 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816002242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816002243 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 655816002244 active site 655816002245 catalytic triad [active] 655816002246 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 655816002247 Predicted integral membrane protein [Function unknown]; Region: COG5578 655816002248 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 655816002249 metal binding site [ion binding]; metal-binding site 655816002250 active site 655816002251 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 655816002252 metal binding site [ion binding]; metal-binding site 655816002253 active site 655816002254 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 655816002255 active site 655816002256 catalytic triad [active] 655816002257 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 655816002258 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 655816002259 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 655816002260 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 655816002261 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 655816002262 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 655816002263 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 655816002264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816002265 putative PBP binding loops; other site 655816002266 dimer interface [polypeptide binding]; other site 655816002267 ABC-ATPase subunit interface; other site 655816002268 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655816002269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816002270 dimer interface [polypeptide binding]; other site 655816002271 conserved gate region; other site 655816002272 putative PBP binding loops; other site 655816002273 ABC-ATPase subunit interface; other site 655816002274 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 655816002275 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 655816002276 NAD(P) binding site [chemical binding]; other site 655816002277 LDH/MDH dimer interface [polypeptide binding]; other site 655816002278 substrate binding site [chemical binding]; other site 655816002279 Predicted membrane protein [Function unknown]; Region: COG2323 655816002280 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 655816002281 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816002282 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 655816002283 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816002284 Uncharacterized small protein [Function unknown]; Region: COG5583 655816002285 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 655816002286 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 655816002287 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816002288 MarR family; Region: MarR; pfam01047 655816002289 hypothetical protein; Provisional; Region: PRK06847 655816002290 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 655816002291 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 655816002292 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 655816002293 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 655816002294 Cytochrome P450; Region: p450; pfam00067 655816002295 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 655816002296 Flavodoxin; Region: Flavodoxin_1; pfam00258 655816002297 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 655816002298 FAD binding pocket [chemical binding]; other site 655816002299 FAD binding motif [chemical binding]; other site 655816002300 catalytic residues [active] 655816002301 NAD binding pocket [chemical binding]; other site 655816002302 phosphate binding motif [ion binding]; other site 655816002303 beta-alpha-beta structure motif; other site 655816002304 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 655816002305 Sulfatase; Region: Sulfatase; pfam00884 655816002306 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 655816002307 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 655816002308 substrate binding site; other site 655816002309 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 655816002310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816002311 NAD(P) binding site [chemical binding]; other site 655816002312 active site 655816002313 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 655816002314 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 655816002315 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816002316 active site 655816002317 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 655816002318 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 655816002319 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816002320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002321 putative substrate translocation pore; other site 655816002322 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 655816002323 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816002324 active site 655816002325 motif I; other site 655816002326 motif II; other site 655816002327 amino acid transporter; Region: 2A0306; TIGR00909 655816002328 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 655816002329 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 655816002330 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655816002331 NAD(P) binding site [chemical binding]; other site 655816002332 catalytic residues [active] 655816002333 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816002334 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 655816002335 dimer interface [polypeptide binding]; other site 655816002336 putative CheW interface [polypeptide binding]; other site 655816002337 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 655816002338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655816002339 Walker A/P-loop; other site 655816002340 ATP binding site [chemical binding]; other site 655816002341 Q-loop/lid; other site 655816002342 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655816002343 ABC transporter signature motif; other site 655816002344 Walker B; other site 655816002345 D-loop; other site 655816002346 ABC transporter; Region: ABC_tran_2; pfam12848 655816002347 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655816002348 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 655816002349 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 655816002350 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 655816002351 DNA binding residues [nucleotide binding] 655816002352 putative dimer interface [polypeptide binding]; other site 655816002353 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 655816002354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002355 putative substrate translocation pore; other site 655816002356 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 655816002357 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655816002358 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655816002359 ABC transporter; Region: ABC_tran_2; pfam12848 655816002360 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655816002361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 655816002362 DEAD-like helicases superfamily; Region: DEXDc; smart00487 655816002363 ATP binding site [chemical binding]; other site 655816002364 putative Mg++ binding site [ion binding]; other site 655816002365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816002366 nucleotide binding region [chemical binding]; other site 655816002367 ATP-binding site [chemical binding]; other site 655816002368 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 655816002369 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 655816002370 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 655816002371 Prostaglandin dehydrogenases; Region: PGDH; cd05288 655816002372 NAD(P) binding site [chemical binding]; other site 655816002373 substrate binding site [chemical binding]; other site 655816002374 dimer interface [polypeptide binding]; other site 655816002375 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655816002376 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655816002377 Walker A/P-loop; other site 655816002378 ATP binding site [chemical binding]; other site 655816002379 Q-loop/lid; other site 655816002380 ABC transporter signature motif; other site 655816002381 Walker B; other site 655816002382 D-loop; other site 655816002383 H-loop/switch region; other site 655816002384 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655816002385 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816002386 ABC-ATPase subunit interface; other site 655816002387 dimer interface [polypeptide binding]; other site 655816002388 putative PBP binding regions; other site 655816002389 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655816002390 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816002391 ABC-ATPase subunit interface; other site 655816002392 dimer interface [polypeptide binding]; other site 655816002393 putative PBP binding regions; other site 655816002394 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 655816002395 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 655816002396 siderophore binding site; other site 655816002397 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 655816002398 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 655816002399 Heat induced stress protein YflT; Region: YflT; pfam11181 655816002400 Amb_all domain; Region: Amb_all; smart00656 655816002401 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 655816002402 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 655816002403 transmembrane helices; other site 655816002404 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 655816002405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816002406 ATP binding site [chemical binding]; other site 655816002407 Mg2+ binding site [ion binding]; other site 655816002408 G-X-G motif; other site 655816002409 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 655816002410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816002411 active site 655816002412 phosphorylation site [posttranslational modification] 655816002413 intermolecular recognition site; other site 655816002414 dimerization interface [polypeptide binding]; other site 655816002415 Transcriptional regulator; Region: CitT; pfam12431 655816002416 HTH domain; Region: HTH_11; cl17392 655816002417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 655816002418 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 655816002419 Citrate transporter; Region: CitMHS; pfam03600 655816002420 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 655816002421 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 655816002422 active site 655816002423 dimer interface [polypeptide binding]; other site 655816002424 acylphosphatase; Provisional; Region: PRK14420 655816002425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 655816002426 MOSC domain; Region: MOSC; pfam03473 655816002427 3-alpha domain; Region: 3-alpha; pfam03475 655816002428 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 655816002429 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 655816002430 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 655816002431 active site 655816002432 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 655816002433 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655816002434 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816002435 active site turn [active] 655816002436 phosphorylation site [posttranslational modification] 655816002437 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 655816002438 Sulfatase; Region: Sulfatase; pfam00884 655816002439 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 655816002440 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 655816002441 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 655816002442 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 655816002443 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 655816002444 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 655816002445 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 655816002446 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 655816002447 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816002448 active site turn [active] 655816002449 phosphorylation site [posttranslational modification] 655816002450 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655816002451 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 655816002452 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 655816002453 Ca binding site [ion binding]; other site 655816002454 active site 655816002455 catalytic site [active] 655816002456 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 655816002457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816002458 DNA-binding site [nucleotide binding]; DNA binding site 655816002459 UTRA domain; Region: UTRA; pfam07702 655816002460 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 655816002461 dimer interface [polypeptide binding]; other site 655816002462 FMN binding site [chemical binding]; other site 655816002463 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 655816002464 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 655816002465 active site 655816002466 metal binding site [ion binding]; metal-binding site 655816002467 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 655816002468 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 655816002469 active site 655816002470 metal binding site [ion binding]; metal-binding site 655816002471 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 655816002472 intracellular protease, PfpI family; Region: PfpI; TIGR01382 655816002473 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 655816002474 proposed catalytic triad [active] 655816002475 conserved cys residue [active] 655816002476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002477 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816002478 putative substrate translocation pore; other site 655816002479 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 655816002480 Low molecular weight phosphatase family; Region: LMWPc; cd00115 655816002481 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 655816002482 active site 655816002483 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 655816002484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002485 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816002486 putative substrate translocation pore; other site 655816002487 calcium/proton exchanger (cax); Region: cax; TIGR00378 655816002488 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 655816002489 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 655816002490 YfkD-like protein; Region: YfkD; pfam14167 655816002491 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 655816002492 Mechanosensitive ion channel; Region: MS_channel; pfam00924 655816002493 Radical SAM superfamily; Region: Radical_SAM; pfam04055 655816002494 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816002495 FeS/SAM binding site; other site 655816002496 YfkB-like domain; Region: YfkB; pfam08756 655816002497 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 655816002498 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 655816002499 NodB motif; other site 655816002500 active site 655816002501 catalytic site [active] 655816002502 Cd binding site [ion binding]; other site 655816002503 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 655816002504 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 655816002505 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 655816002506 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 655816002507 oligomer interface [polypeptide binding]; other site 655816002508 metal binding site [ion binding]; metal-binding site 655816002509 metal binding site [ion binding]; metal-binding site 655816002510 putative Cl binding site [ion binding]; other site 655816002511 aspartate ring; other site 655816002512 basic sphincter; other site 655816002513 hydrophobic gate; other site 655816002514 periplasmic entrance; other site 655816002515 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 655816002516 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 655816002517 minor groove reading motif; other site 655816002518 helix-hairpin-helix signature motif; other site 655816002519 substrate binding pocket [chemical binding]; other site 655816002520 active site 655816002521 TRAM domain; Region: TRAM; pfam01938 655816002522 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 655816002523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816002524 S-adenosylmethionine binding site [chemical binding]; other site 655816002525 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 655816002526 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 655816002527 FMN binding site [chemical binding]; other site 655816002528 active site 655816002529 catalytic residues [active] 655816002530 substrate binding site [chemical binding]; other site 655816002531 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 655816002532 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 655816002533 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 655816002534 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 655816002535 tetramer interface [polypeptide binding]; other site 655816002536 TPP-binding site [chemical binding]; other site 655816002537 heterodimer interface [polypeptide binding]; other site 655816002538 phosphorylation loop region [posttranslational modification] 655816002539 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 655816002540 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 655816002541 alpha subunit interface [polypeptide binding]; other site 655816002542 TPP binding site [chemical binding]; other site 655816002543 heterodimer interface [polypeptide binding]; other site 655816002544 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655816002545 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 655816002546 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 655816002547 E3 interaction surface; other site 655816002548 lipoyl attachment site [posttranslational modification]; other site 655816002549 e3 binding domain; Region: E3_binding; pfam02817 655816002550 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 655816002551 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 655816002552 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816002553 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 655816002554 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 655816002555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816002556 Walker A motif; other site 655816002557 ATP binding site [chemical binding]; other site 655816002558 Walker B motif; other site 655816002559 arginine finger; other site 655816002560 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 655816002561 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 655816002562 hypothetical protein; Provisional; Region: PRK02237 655816002563 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 655816002564 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 655816002565 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 655816002566 NAD binding site [chemical binding]; other site 655816002567 sugar binding site [chemical binding]; other site 655816002568 divalent metal binding site [ion binding]; other site 655816002569 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816002570 dimer interface [polypeptide binding]; other site 655816002571 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 655816002572 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 655816002573 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 655816002574 putative active site [active] 655816002575 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 655816002576 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 655816002577 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816002578 active site turn [active] 655816002579 phosphorylation site [posttranslational modification] 655816002580 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816002581 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655816002582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655816002583 Walker A/P-loop; other site 655816002584 ATP binding site [chemical binding]; other site 655816002585 Q-loop/lid; other site 655816002586 ABC transporter signature motif; other site 655816002587 Walker B; other site 655816002588 D-loop; other site 655816002589 H-loop/switch region; other site 655816002590 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816002591 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655816002592 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 655816002593 Walker A/P-loop; other site 655816002594 ATP binding site [chemical binding]; other site 655816002595 Q-loop/lid; other site 655816002596 ABC transporter signature motif; other site 655816002597 Walker B; other site 655816002598 D-loop; other site 655816002599 H-loop/switch region; other site 655816002600 Predicted membrane protein [Function unknown]; Region: COG2259 655816002601 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 655816002602 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 655816002603 putative metal binding site [ion binding]; other site 655816002604 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 655816002605 active site 655816002606 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816002607 Histidine kinase; Region: HisKA_3; pfam07730 655816002608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816002609 ATP binding site [chemical binding]; other site 655816002610 Mg2+ binding site [ion binding]; other site 655816002611 G-X-G motif; other site 655816002612 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816002613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816002614 active site 655816002615 phosphorylation site [posttranslational modification] 655816002616 intermolecular recognition site; other site 655816002617 dimerization interface [polypeptide binding]; other site 655816002618 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816002619 DNA binding residues [nucleotide binding] 655816002620 dimerization interface [polypeptide binding]; other site 655816002621 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816002622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655816002623 Walker A/P-loop; other site 655816002624 ATP binding site [chemical binding]; other site 655816002625 Q-loop/lid; other site 655816002626 ABC transporter signature motif; other site 655816002627 Walker B; other site 655816002628 D-loop; other site 655816002629 H-loop/switch region; other site 655816002630 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 655816002631 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 655816002632 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 655816002633 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 655816002634 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816002635 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 655816002636 Predicted transcriptional regulators [Transcription]; Region: COG1695 655816002637 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 655816002638 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 655816002639 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 655816002640 Lipase (class 2); Region: Lipase_2; pfam01674 655816002641 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 655816002642 Acyltransferase family; Region: Acyl_transf_3; pfam01757 655816002643 metal-dependent hydrolase; Provisional; Region: PRK13291 655816002644 DinB superfamily; Region: DinB_2; pfam12867 655816002645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002646 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816002647 putative substrate translocation pore; other site 655816002648 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816002649 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816002650 putative Zn2+ binding site [ion binding]; other site 655816002651 putative DNA binding site [nucleotide binding]; other site 655816002652 Predicted integral membrane protein [Function unknown]; Region: COG0392 655816002653 Uncharacterized conserved protein [Function unknown]; Region: COG2898 655816002654 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 655816002655 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 655816002656 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 655816002657 siderophore binding site; other site 655816002658 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655816002659 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816002660 ABC-ATPase subunit interface; other site 655816002661 dimer interface [polypeptide binding]; other site 655816002662 putative PBP binding regions; other site 655816002663 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655816002664 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816002665 ABC-ATPase subunit interface; other site 655816002666 dimer interface [polypeptide binding]; other site 655816002667 putative PBP binding regions; other site 655816002668 sequence corresponding to yfhB is present, but has been inactivated by a small deletion resulting in a frameshift 655816002669 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 655816002670 putative FMN binding site [chemical binding]; other site 655816002671 YfhD-like protein; Region: YfhD; pfam14151 655816002672 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 655816002673 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 655816002674 putative NAD(P) binding site [chemical binding]; other site 655816002675 putative active site [active] 655816002676 recombination regulator RecX; Provisional; Region: recX; PRK14135 655816002677 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 655816002678 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 655816002679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002680 putative substrate translocation pore; other site 655816002681 Small acid-soluble spore protein K family; Region: SspK; pfam08176 655816002682 WVELL protein; Region: WVELL; pfam14043 655816002683 Bacterial SH3 domain; Region: SH3_3; pfam08239 655816002684 SdpI/YhfL protein family; Region: SdpI; pfam13630 655816002685 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 655816002686 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 655816002687 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 655816002688 catalytic site [active] 655816002689 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 655816002690 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 655816002691 Ligand binding site; other site 655816002692 Putative Catalytic site; other site 655816002693 DXD motif; other site 655816002694 Predicted membrane protein [Function unknown]; Region: COG4485 655816002695 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 655816002696 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 655816002697 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 655816002698 minor groove reading motif; other site 655816002699 helix-hairpin-helix signature motif; other site 655816002700 substrate binding pocket [chemical binding]; other site 655816002701 active site 655816002702 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 655816002703 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 655816002704 DNA binding and oxoG recognition site [nucleotide binding] 655816002705 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 655816002706 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 655816002707 putative NAD(P) binding site [chemical binding]; other site 655816002708 active site 655816002709 YgaB-like protein; Region: YgaB; pfam14182 655816002710 hypothetical protein; Provisional; Region: PRK13662 655816002711 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816002712 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655816002713 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 655816002714 Walker A/P-loop; other site 655816002715 ATP binding site [chemical binding]; other site 655816002716 Q-loop/lid; other site 655816002717 ABC transporter signature motif; other site 655816002718 Walker B; other site 655816002719 D-loop; other site 655816002720 H-loop/switch region; other site 655816002721 Predicted membrane protein [Function unknown]; Region: COG4129 655816002722 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 655816002723 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 655816002724 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816002725 inhibitor-cofactor binding pocket; inhibition site 655816002726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816002727 catalytic residue [active] 655816002728 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 655816002729 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 655816002730 catalytic triad [active] 655816002731 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 655816002732 metal binding site 2 [ion binding]; metal-binding site 655816002733 putative DNA binding helix; other site 655816002734 metal binding site 1 [ion binding]; metal-binding site 655816002735 dimer interface [polypeptide binding]; other site 655816002736 structural Zn2+ binding site [ion binding]; other site 655816002737 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 655816002738 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 655816002739 SpoOM protein; Region: Spo0M; pfam07070 655816002740 Coat F domain; Region: Coat_F; pfam07875 655816002741 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 655816002742 active site pocket [active] 655816002743 oxyanion hole [active] 655816002744 catalytic triad [active] 655816002745 active site nucleophile [active] 655816002746 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 655816002747 ThiC-associated domain; Region: ThiC-associated; pfam13667 655816002748 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 655816002749 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 655816002750 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 655816002751 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 655816002752 tetramer interface [polypeptide binding]; other site 655816002753 heme binding pocket [chemical binding]; other site 655816002754 NADPH binding site [chemical binding]; other site 655816002755 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 655816002756 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 655816002757 Walker A/P-loop; other site 655816002758 ATP binding site [chemical binding]; other site 655816002759 Q-loop/lid; other site 655816002760 ABC transporter signature motif; other site 655816002761 Walker B; other site 655816002762 D-loop; other site 655816002763 H-loop/switch region; other site 655816002764 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 655816002765 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655816002766 substrate binding pocket [chemical binding]; other site 655816002767 membrane-bound complex binding site; other site 655816002768 hinge residues; other site 655816002769 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 655816002770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816002771 dimer interface [polypeptide binding]; other site 655816002772 conserved gate region; other site 655816002773 putative PBP binding loops; other site 655816002774 ABC-ATPase subunit interface; other site 655816002775 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 655816002776 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 655816002777 active site 655816002778 dimer interface [polypeptide binding]; other site 655816002779 non-prolyl cis peptide bond; other site 655816002780 insertion regions; other site 655816002781 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 655816002782 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 655816002783 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816002784 non-specific DNA binding site [nucleotide binding]; other site 655816002785 salt bridge; other site 655816002786 sequence-specific DNA binding site [nucleotide binding]; other site 655816002787 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 655816002788 epoxyqueuosine reductase; Region: TIGR00276 655816002789 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 655816002790 Putative amidase domain; Region: Amidase_6; pfam12671 655816002791 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 655816002792 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 655816002793 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 655816002794 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 655816002795 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 655816002796 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 655816002797 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 655816002798 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 655816002799 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816002800 MarR family; Region: MarR; pfam01047 655816002801 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 655816002802 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 655816002803 carboxyltransferase (CT) interaction site; other site 655816002804 biotinylation site [posttranslational modification]; other site 655816002805 HlyD family secretion protein; Region: HlyD_3; pfam13437 655816002806 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 655816002807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002808 putative substrate translocation pore; other site 655816002809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002810 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 655816002811 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 655816002812 Predicted transcriptional regulators [Transcription]; Region: COG1725 655816002813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816002814 DNA-binding site [nucleotide binding]; DNA binding site 655816002815 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 655816002816 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 655816002817 Walker A/P-loop; other site 655816002818 ATP binding site [chemical binding]; other site 655816002819 Q-loop/lid; other site 655816002820 ABC transporter signature motif; other site 655816002821 Walker B; other site 655816002822 D-loop; other site 655816002823 H-loop/switch region; other site 655816002824 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816002825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655816002826 Walker A/P-loop; other site 655816002827 ATP binding site [chemical binding]; other site 655816002828 Q-loop/lid; other site 655816002829 ABC transporter signature motif; other site 655816002830 Walker B; other site 655816002831 D-loop; other site 655816002832 H-loop/switch region; other site 655816002833 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 655816002834 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 655816002835 DNA-binding site [nucleotide binding]; DNA binding site 655816002836 RNA-binding motif; other site 655816002837 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 655816002838 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 655816002839 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 655816002840 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 655816002841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655816002842 metal binding site [ion binding]; metal-binding site 655816002843 active site 655816002844 I-site; other site 655816002845 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 655816002846 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 655816002847 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 655816002848 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 655816002849 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 655816002850 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 655816002851 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 655816002852 generic binding surface II; other site 655816002853 generic binding surface I; other site 655816002854 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 655816002855 generic binding surface II; other site 655816002856 generic binding surface I; other site 655816002857 Staphylococcal nuclease homologues; Region: SNc; smart00318 655816002858 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 655816002859 Catalytic site; other site 655816002860 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 655816002861 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 655816002862 putative active site [active] 655816002863 putative metal binding site [ion binding]; other site 655816002864 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 655816002865 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 655816002866 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 655816002867 active site 655816002868 catalytic site [active] 655816002869 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 655816002870 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816002871 RNA binding surface [nucleotide binding]; other site 655816002872 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 655816002873 active site 655816002874 FOG: CBS domain [General function prediction only]; Region: COG0517 655816002875 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 655816002876 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 655816002877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816002878 motif II; other site 655816002879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816002880 Coenzyme A binding pocket [chemical binding]; other site 655816002881 Predicted amidohydrolase [General function prediction only]; Region: COG0388 655816002882 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 655816002883 putative active site [active] 655816002884 catalytic triad [active] 655816002885 putative dimer interface [polypeptide binding]; other site 655816002886 Predicted permeases [General function prediction only]; Region: COG0679 655816002887 aminotransferase; Validated; Region: PRK07678 655816002888 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816002889 inhibitor-cofactor binding pocket; inhibition site 655816002890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816002891 catalytic residue [active] 655816002892 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 655816002893 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 655816002894 amphipathic channel; other site 655816002895 Asn-Pro-Ala signature motifs; other site 655816002896 glycerol kinase; Provisional; Region: glpK; PRK00047 655816002897 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 655816002898 N- and C-terminal domain interface [polypeptide binding]; other site 655816002899 active site 655816002900 MgATP binding site [chemical binding]; other site 655816002901 catalytic site [active] 655816002902 metal binding site [ion binding]; metal-binding site 655816002903 glycerol binding site [chemical binding]; other site 655816002904 homotetramer interface [polypeptide binding]; other site 655816002905 homodimer interface [polypeptide binding]; other site 655816002906 FBP binding site [chemical binding]; other site 655816002907 protein IIAGlc interface [polypeptide binding]; other site 655816002908 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 655816002909 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 655816002910 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 655816002911 active site 655816002912 substrate binding site [chemical binding]; other site 655816002913 metal binding site [ion binding]; metal-binding site 655816002914 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 655816002915 GAF domain; Region: GAF; pfam01590 655816002916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816002917 Histidine kinase; Region: HisKA_3; pfam07730 655816002918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816002919 ATP binding site [chemical binding]; other site 655816002920 Mg2+ binding site [ion binding]; other site 655816002921 G-X-G motif; other site 655816002922 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816002923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816002924 active site 655816002925 phosphorylation site [posttranslational modification] 655816002926 intermolecular recognition site; other site 655816002927 dimerization interface [polypeptide binding]; other site 655816002928 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816002929 DNA binding residues [nucleotide binding] 655816002930 dimerization interface [polypeptide binding]; other site 655816002931 Predicted flavoprotein [General function prediction only]; Region: COG0431 655816002932 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 655816002933 YhdB-like protein; Region: YhdB; pfam14148 655816002934 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 655816002935 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816002936 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816002937 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816002938 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 655816002939 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816002940 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816002941 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 655816002942 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 655816002943 NlpC/P60 family; Region: NLPC_P60; pfam00877 655816002944 Transcriptional regulator; Region: Rrf2; cl17282 655816002945 Rrf2 family protein; Region: rrf2_super; TIGR00738 655816002946 Conserved TM helix; Region: TM_helix; pfam05552 655816002947 Conserved TM helix; Region: TM_helix; pfam05552 655816002948 Conserved TM helix; Region: TM_helix; pfam05552 655816002949 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 655816002950 SpoVR like protein; Region: SpoVR; pfam04293 655816002951 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 655816002952 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 655816002953 dimer interface [polypeptide binding]; other site 655816002954 active site 655816002955 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816002956 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816002957 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816002958 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 655816002959 NlpC/P60 family; Region: NLPC_P60; pfam00877 655816002960 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816002961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816002962 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655816002963 dimerization interface [polypeptide binding]; other site 655816002964 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 655816002965 dimer interface [polypeptide binding]; other site 655816002966 Citrate synthase; Region: Citrate_synt; pfam00285 655816002967 active site 655816002968 citrylCoA binding site [chemical binding]; other site 655816002969 oxalacetate/citrate binding site [chemical binding]; other site 655816002970 coenzyme A binding site [chemical binding]; other site 655816002971 catalytic triad [active] 655816002972 short chain dehydrogenase; Provisional; Region: PRK06701 655816002973 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 655816002974 NAD binding site [chemical binding]; other site 655816002975 metal binding site [ion binding]; metal-binding site 655816002976 active site 655816002977 amino acid transporter; Region: 2A0306; TIGR00909 655816002978 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 655816002979 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 655816002980 Na2 binding site [ion binding]; other site 655816002981 putative substrate binding site 1 [chemical binding]; other site 655816002982 Na binding site 1 [ion binding]; other site 655816002983 putative substrate binding site 2 [chemical binding]; other site 655816002984 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816002985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816002986 DNA-binding site [nucleotide binding]; DNA binding site 655816002987 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816002988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816002989 homodimer interface [polypeptide binding]; other site 655816002990 catalytic residue [active] 655816002991 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 655816002992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816002993 Coenzyme A binding pocket [chemical binding]; other site 655816002994 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 655816002995 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 655816002996 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 655816002997 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816002998 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816002999 DNA binding residues [nucleotide binding] 655816003000 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816003001 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655816003002 active site 655816003003 catalytic tetrad [active] 655816003004 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 655816003005 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 655816003006 putative acyl-acceptor binding pocket; other site 655816003007 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 655816003008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 655816003009 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 655816003010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816003011 NAD(P) binding site [chemical binding]; other site 655816003012 active site 655816003013 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 655816003014 Domain of unknown function DUF21; Region: DUF21; pfam01595 655816003015 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 655816003016 Transporter associated domain; Region: CorC_HlyC; smart01091 655816003017 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 655816003018 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 655816003019 DNA binding residues [nucleotide binding] 655816003020 putative dimer interface [polypeptide binding]; other site 655816003021 aspartate aminotransferase; Provisional; Region: PRK06836 655816003022 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816003023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003024 homodimer interface [polypeptide binding]; other site 655816003025 catalytic residue [active] 655816003026 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 655816003027 Domain of unknown function DUF21; Region: DUF21; pfam01595 655816003028 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 655816003029 Transporter associated domain; Region: CorC_HlyC; smart01091 655816003030 camphor resistance protein CrcB; Provisional; Region: PRK14213 655816003031 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 655816003032 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 655816003033 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 655816003034 active site 655816003035 catalytic site [active] 655816003036 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 655816003037 Mechanosensitive ion channel; Region: MS_channel; pfam00924 655816003038 NAD-dependent deacetylase; Provisional; Region: PRK00481 655816003039 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 655816003040 NAD+ binding site [chemical binding]; other site 655816003041 substrate binding site [chemical binding]; other site 655816003042 Zn binding site [ion binding]; other site 655816003043 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 655816003044 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 655816003045 NodB motif; other site 655816003046 active site 655816003047 catalytic site [active] 655816003048 Zn binding site [ion binding]; other site 655816003049 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 655816003050 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 655816003051 homodimer interface [polypeptide binding]; other site 655816003052 substrate-cofactor binding pocket; other site 655816003053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003054 catalytic residue [active] 655816003055 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 655816003056 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 655816003057 Ligand Binding Site [chemical binding]; other site 655816003058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655816003059 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 655816003060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655816003061 Walker A/P-loop; other site 655816003062 ATP binding site [chemical binding]; other site 655816003063 Q-loop/lid; other site 655816003064 ABC transporter signature motif; other site 655816003065 Walker B; other site 655816003066 D-loop; other site 655816003067 H-loop/switch region; other site 655816003068 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816003069 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655816003070 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 655816003071 Walker A/P-loop; other site 655816003072 ATP binding site [chemical binding]; other site 655816003073 Q-loop/lid; other site 655816003074 ABC transporter signature motif; other site 655816003075 Walker B; other site 655816003076 D-loop; other site 655816003077 H-loop/switch region; other site 655816003078 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 655816003079 NADH(P)-binding; Region: NAD_binding_10; pfam13460 655816003080 NAD binding site [chemical binding]; other site 655816003081 substrate binding site [chemical binding]; other site 655816003082 putative active site [active] 655816003083 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 655816003084 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 655816003085 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 655816003086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 655816003087 hypothetical protein; Provisional; Region: PRK13676 655816003088 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 655816003089 HEAT repeats; Region: HEAT_2; pfam13646 655816003090 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 655816003091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816003092 active site 655816003093 motif I; other site 655816003094 motif II; other site 655816003095 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 655816003096 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 655816003097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816003098 FeS/SAM binding site; other site 655816003099 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 655816003100 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 655816003101 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 655816003102 TrkA-C domain; Region: TrkA_C; pfam02080 655816003103 enoyl-CoA hydratase; Provisional; Region: PRK07659 655816003104 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816003105 substrate binding site [chemical binding]; other site 655816003106 oxyanion hole (OAH) forming residues; other site 655816003107 trimer interface [polypeptide binding]; other site 655816003108 YhzD-like protein; Region: YhzD; pfam14120 655816003109 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 655816003110 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 655816003111 Walker A/P-loop; other site 655816003112 ATP binding site [chemical binding]; other site 655816003113 Q-loop/lid; other site 655816003114 ABC transporter signature motif; other site 655816003115 Walker B; other site 655816003116 D-loop; other site 655816003117 H-loop/switch region; other site 655816003118 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 655816003119 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 655816003120 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 655816003121 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 655816003122 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 655816003123 active site 655816003124 metal binding site [ion binding]; metal-binding site 655816003125 DNA binding site [nucleotide binding] 655816003126 Uncharacterized conserved protein [Function unknown]; Region: COG4717 655816003127 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 655816003128 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 655816003129 generic binding surface II; other site 655816003130 generic binding surface I; other site 655816003131 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816003132 Zn2+ binding site [ion binding]; other site 655816003133 Mg2+ binding site [ion binding]; other site 655816003134 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 655816003135 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 655816003136 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 655816003137 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 655816003138 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 655816003139 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 655816003140 transcriptional regulator Hpr; Provisional; Region: PRK13777 655816003141 MarR family; Region: MarR; pfam01047 655816003142 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 655816003143 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 655816003144 homodimer interface [polypeptide binding]; other site 655816003145 substrate-cofactor binding pocket; other site 655816003146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003147 catalytic residue [active] 655816003148 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 655816003149 HIT family signature motif; other site 655816003150 catalytic residue [active] 655816003151 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 655816003152 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 655816003153 Walker A/P-loop; other site 655816003154 ATP binding site [chemical binding]; other site 655816003155 Q-loop/lid; other site 655816003156 ABC transporter signature motif; other site 655816003157 Walker B; other site 655816003158 D-loop; other site 655816003159 H-loop/switch region; other site 655816003160 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 655816003161 EcsC protein family; Region: EcsC; pfam12787 655816003162 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 655816003163 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 655816003164 metal binding site [ion binding]; metal-binding site 655816003165 dimer interface [polypeptide binding]; other site 655816003166 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 655816003167 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 655816003168 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 655816003169 Transglycosylase; Region: Transgly; pfam00912 655816003170 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 655816003171 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 655816003172 substrate binding site [chemical binding]; other site 655816003173 active site 655816003174 ferrochelatase; Provisional; Region: PRK12435 655816003175 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 655816003176 C-terminal domain interface [polypeptide binding]; other site 655816003177 active site 655816003178 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 655816003179 active site 655816003180 N-terminal domain interface [polypeptide binding]; other site 655816003181 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 655816003182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655816003183 SEA domain; Region: SEA; cl02507 655816003184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816003185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816003186 Predicted membrane protein [Function unknown]; Region: COG1511 655816003187 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 655816003188 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 655816003189 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 655816003190 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 655816003191 dimer interface [polypeptide binding]; other site 655816003192 active site 655816003193 CoA binding pocket [chemical binding]; other site 655816003194 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 655816003195 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 655816003196 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 655816003197 putative oligomer interface [polypeptide binding]; other site 655816003198 putative active site [active] 655816003199 metal binding site [ion binding]; metal-binding site 655816003200 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 655816003201 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 655816003202 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 655816003203 YhfH-like protein; Region: YhfH; pfam14149 655816003204 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 655816003205 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 655816003206 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 655816003207 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 655816003208 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 655816003209 NADH(P)-binding; Region: NAD_binding_10; pfam13460 655816003210 NAD(P) binding site [chemical binding]; other site 655816003211 putative active site [active] 655816003212 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 655816003213 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 655816003214 acyl-activating enzyme (AAE) consensus motif; other site 655816003215 putative AMP binding site [chemical binding]; other site 655816003216 putative active site [active] 655816003217 putative CoA binding site [chemical binding]; other site 655816003218 Peptidase family M48; Region: Peptidase_M48; pfam01435 655816003219 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 655816003220 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 655816003221 active site 655816003222 catalytic residues [active] 655816003223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 655816003224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816003225 Coenzyme A binding pocket [chemical binding]; other site 655816003226 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 655816003227 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 655816003228 putative NADP binding site [chemical binding]; other site 655816003229 putative dimer interface [polypeptide binding]; other site 655816003230 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 655816003231 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 655816003232 siderophore binding site; other site 655816003233 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 655816003234 catalytic core [active] 655816003235 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 655816003236 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 655816003237 dimer interface [polypeptide binding]; other site 655816003238 active site 655816003239 acyl-CoA synthetase; Validated; Region: PRK07638 655816003240 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 655816003241 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 655816003242 acyl-activating enzyme (AAE) consensus motif; other site 655816003243 acyl-activating enzyme (AAE) consensus motif; other site 655816003244 AMP binding site [chemical binding]; other site 655816003245 active site 655816003246 CoA binding site [chemical binding]; other site 655816003247 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 655816003248 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 655816003249 heme-binding site [chemical binding]; other site 655816003250 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 655816003251 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816003252 Active site flap [active] 655816003253 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816003254 dimer interface [polypeptide binding]; other site 655816003255 putative CheW interface [polypeptide binding]; other site 655816003256 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 655816003257 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 655816003258 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 655816003259 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 655816003260 [2Fe-2S] cluster binding site [ion binding]; other site 655816003261 short chain dehydrogenase; Provisional; Region: PRK06701 655816003262 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 655816003263 NAD binding site [chemical binding]; other site 655816003264 metal binding site [ion binding]; metal-binding site 655816003265 active site 655816003266 IDEAL domain; Region: IDEAL; pfam08858 655816003267 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 655816003268 oxidoreductase; Provisional; Region: PRK07985 655816003269 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 655816003270 NAD binding site [chemical binding]; other site 655816003271 metal binding site [ion binding]; metal-binding site 655816003272 active site 655816003273 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 655816003274 Na binding site [ion binding]; other site 655816003275 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 655816003276 Uncharacterized conserved protein [Function unknown]; Region: COG0398 655816003277 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 655816003278 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 655816003279 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 655816003280 Catalytic site [active] 655816003281 hypothetical protein; Provisional; Region: PRK08244 655816003282 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 655816003283 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 655816003284 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816003285 MarR family; Region: MarR; pfam01047 655816003286 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 655816003287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816003288 putative substrate translocation pore; other site 655816003289 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816003290 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655816003291 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 655816003292 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 655816003293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816003294 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 655816003295 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 655816003296 inhibitor-cofactor binding pocket; inhibition site 655816003297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003298 catalytic residue [active] 655816003299 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816003300 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816003301 DNA binding site [nucleotide binding] 655816003302 domain linker motif; other site 655816003303 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 655816003304 putative dimerization interface [polypeptide binding]; other site 655816003305 putative ligand binding site [chemical binding]; other site 655816003306 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 655816003307 Putative ammonia monooxygenase; Region: AmoA; pfam05145 655816003308 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 655816003309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816003310 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816003311 putative substrate translocation pore; other site 655816003312 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 655816003313 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 655816003314 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 655816003315 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 655816003316 dimerization interface [polypeptide binding]; other site 655816003317 Uncharacterized conserved protein [Function unknown]; Region: COG1633 655816003318 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 655816003319 dinuclear metal binding motif [ion binding]; other site 655816003320 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 655816003321 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 655816003322 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 655816003323 Part of AAA domain; Region: AAA_19; pfam13245 655816003324 Family description; Region: UvrD_C_2; pfam13538 655816003325 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 655816003326 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 655816003327 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 655816003328 active site 655816003329 metal binding site [ion binding]; metal-binding site 655816003330 DNA binding site [nucleotide binding] 655816003331 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 655816003332 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 655816003333 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 655816003334 Walker A/P-loop; other site 655816003335 ATP binding site [chemical binding]; other site 655816003336 Q-loop/lid; other site 655816003337 ABC transporter signature motif; other site 655816003338 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 655816003339 ABC transporter signature motif; other site 655816003340 Walker B; other site 655816003341 D-loop; other site 655816003342 H-loop/switch region; other site 655816003343 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 655816003344 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 655816003345 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 655816003346 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 655816003347 Spore germination protein GerPC; Region: GerPC; pfam10737 655816003348 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 655816003349 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 655816003350 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 655816003351 CotH protein; Region: CotH; pfam08757 655816003352 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 655816003353 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 655816003354 hypothetical protein; Provisional; Region: PRK13673 655816003355 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 655816003356 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 655816003357 active site 655816003358 catalytic triad [active] 655816003359 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 655816003360 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 655816003361 active site 655816003362 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 655816003363 dimer interface [polypeptide binding]; other site 655816003364 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 655816003365 Ligand Binding Site [chemical binding]; other site 655816003366 Molecular Tunnel; other site 655816003367 DinB family; Region: DinB; cl17821 655816003368 DinB superfamily; Region: DinB_2; pfam12867 655816003369 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 655816003370 substrate binding pocket [chemical binding]; other site 655816003371 aspartate-rich region 2; other site 655816003372 substrate-Mg2+ binding site; other site 655816003373 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 655816003374 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 655816003375 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 655816003376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816003377 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816003378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816003379 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816003380 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816003381 DNA binding site [nucleotide binding] 655816003382 domain linker motif; other site 655816003383 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 655816003384 dimerization interface [polypeptide binding]; other site 655816003385 ligand binding site [chemical binding]; other site 655816003386 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816003387 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655816003388 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 655816003389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 655816003390 Lysine efflux permease [General function prediction only]; Region: COG1279 655816003391 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816003392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816003393 DNA-binding site [nucleotide binding]; DNA binding site 655816003394 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816003395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003396 homodimer interface [polypeptide binding]; other site 655816003397 catalytic residue [active] 655816003398 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 655816003399 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 655816003400 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 655816003401 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 655816003402 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 655816003403 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 655816003404 ligand-binding site [chemical binding]; other site 655816003405 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 655816003406 ATP-sulfurylase; Region: ATPS; cd00517 655816003407 active site 655816003408 HXXH motif; other site 655816003409 flexible loop; other site 655816003410 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 655816003411 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 655816003412 Active Sites [active] 655816003413 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 655816003414 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 655816003415 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 655816003416 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816003417 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816003418 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 655816003419 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 655816003420 active site pocket [active] 655816003421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816003422 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816003423 putative substrate translocation pore; other site 655816003424 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 655816003425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 655816003426 Coenzyme A binding pocket [chemical binding]; other site 655816003427 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 655816003428 Coenzyme A binding pocket [chemical binding]; other site 655816003429 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 655816003430 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 655816003431 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 655816003432 FAD binding site [chemical binding]; other site 655816003433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 655816003434 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 655816003435 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 655816003436 S1 domain; Region: S1_2; pfam13509 655816003437 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 655816003438 RNA binding site [nucleotide binding]; other site 655816003439 EDD domain protein, DegV family; Region: DegV; TIGR00762 655816003440 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 655816003441 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816003442 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816003443 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816003444 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 655816003445 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 655816003446 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 655816003447 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 655816003448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816003449 motif II; other site 655816003450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816003451 esterase; Provisional; Region: PRK10566 655816003452 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 655816003453 Serine hydrolase (FSH1); Region: FSH1; pfam03959 655816003454 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 655816003455 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 655816003456 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 655816003457 FAD binding domain; Region: FAD_binding_4; pfam01565 655816003458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816003459 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816003460 putative substrate translocation pore; other site 655816003461 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 655816003462 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 655816003463 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 655816003464 heterotetramer interface [polypeptide binding]; other site 655816003465 active site pocket [active] 655816003466 cleavage site 655816003467 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 655816003468 nucleotide binding site [chemical binding]; other site 655816003469 N-acetyl-L-glutamate binding site [chemical binding]; other site 655816003470 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 655816003471 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816003472 inhibitor-cofactor binding pocket; inhibition site 655816003473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003474 catalytic residue [active] 655816003475 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 655816003476 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 655816003477 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 655816003478 catalytic site [active] 655816003479 subunit interface [polypeptide binding]; other site 655816003480 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 655816003481 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816003482 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 655816003483 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 655816003484 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816003485 ATP-grasp domain; Region: ATP-grasp_4; cl17255 655816003486 ornithine carbamoyltransferase; Provisional; Region: PRK00779 655816003487 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 655816003488 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 655816003489 YjzC-like protein; Region: YjzC; pfam14168 655816003490 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 655816003491 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 655816003492 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 655816003493 putative ligand binding site [chemical binding]; other site 655816003494 ComZ; Region: ComZ; pfam10815 655816003495 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 655816003496 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 655816003497 dimer interface [polypeptide binding]; other site 655816003498 active site 655816003499 CoA binding pocket [chemical binding]; other site 655816003500 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 655816003501 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 655816003502 dimer interface [polypeptide binding]; other site 655816003503 active site 655816003504 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 655816003505 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 655816003506 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655816003507 Walker A/P-loop; other site 655816003508 ATP binding site [chemical binding]; other site 655816003509 Q-loop/lid; other site 655816003510 ABC transporter signature motif; other site 655816003511 Walker B; other site 655816003512 D-loop; other site 655816003513 H-loop/switch region; other site 655816003514 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 655816003515 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 655816003516 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655816003517 Walker A/P-loop; other site 655816003518 ATP binding site [chemical binding]; other site 655816003519 Q-loop/lid; other site 655816003520 ABC transporter signature motif; other site 655816003521 Walker B; other site 655816003522 D-loop; other site 655816003523 H-loop/switch region; other site 655816003524 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 655816003525 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 655816003526 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 655816003527 peptide binding site [polypeptide binding]; other site 655816003528 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 655816003529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816003530 dimer interface [polypeptide binding]; other site 655816003531 conserved gate region; other site 655816003532 putative PBP binding loops; other site 655816003533 ABC-ATPase subunit interface; other site 655816003534 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 655816003535 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 655816003536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816003537 dimer interface [polypeptide binding]; other site 655816003538 conserved gate region; other site 655816003539 putative PBP binding loops; other site 655816003540 ABC-ATPase subunit interface; other site 655816003541 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 655816003542 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 655816003543 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 655816003544 active site 655816003545 HIGH motif; other site 655816003546 dimer interface [polypeptide binding]; other site 655816003547 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 655816003548 KMSKS motif; other site 655816003549 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 655816003550 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 655816003551 peptide binding site [polypeptide binding]; other site 655816003552 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 655816003553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816003554 dimer interface [polypeptide binding]; other site 655816003555 conserved gate region; other site 655816003556 putative PBP binding loops; other site 655816003557 ABC-ATPase subunit interface; other site 655816003558 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 655816003559 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 655816003560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816003561 dimer interface [polypeptide binding]; other site 655816003562 conserved gate region; other site 655816003563 putative PBP binding loops; other site 655816003564 ABC-ATPase subunit interface; other site 655816003565 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 655816003566 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655816003567 Walker A/P-loop; other site 655816003568 ATP binding site [chemical binding]; other site 655816003569 Q-loop/lid; other site 655816003570 ABC transporter signature motif; other site 655816003571 Walker B; other site 655816003572 D-loop; other site 655816003573 H-loop/switch region; other site 655816003574 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 655816003575 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 655816003576 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655816003577 Walker A/P-loop; other site 655816003578 ATP binding site [chemical binding]; other site 655816003579 Q-loop/lid; other site 655816003580 ABC transporter signature motif; other site 655816003581 Walker B; other site 655816003582 D-loop; other site 655816003583 H-loop/switch region; other site 655816003584 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 655816003585 H+ Antiporter protein; Region: 2A0121; TIGR00900 655816003586 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 655816003587 ArsC family; Region: ArsC; pfam03960 655816003588 putative catalytic residues [active] 655816003589 thiol/disulfide switch; other site 655816003590 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 655816003591 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 655816003592 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 655816003593 oligoendopeptidase F; Region: pepF; TIGR00181 655816003594 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 655816003595 active site 655816003596 Zn binding site [ion binding]; other site 655816003597 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 655816003598 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 655816003599 catalytic residues [active] 655816003600 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 655816003601 apolar tunnel; other site 655816003602 heme binding site [chemical binding]; other site 655816003603 dimerization interface [polypeptide binding]; other site 655816003604 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 655816003605 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 655816003606 N-acetyl-D-glucosamine binding site [chemical binding]; other site 655816003607 catalytic residue [active] 655816003608 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 655816003609 putative active site [active] 655816003610 putative metal binding residues [ion binding]; other site 655816003611 signature motif; other site 655816003612 putative triphosphate binding site [ion binding]; other site 655816003613 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 655816003614 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 655816003615 synthetase active site [active] 655816003616 NTP binding site [chemical binding]; other site 655816003617 metal binding site [ion binding]; metal-binding site 655816003618 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 655816003619 ATP-NAD kinase; Region: NAD_kinase; pfam01513 655816003620 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 655816003621 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 655816003622 active site 655816003623 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 655816003624 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 655816003625 active site 655816003626 metal binding site [ion binding]; metal-binding site 655816003627 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 655816003628 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 655816003629 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 655816003630 TrkA-N domain; Region: TrkA_N; pfam02254 655816003631 TrkA-C domain; Region: TrkA_C; pfam02080 655816003632 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 655816003633 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 655816003634 thiamine phosphate binding site [chemical binding]; other site 655816003635 active site 655816003636 pyrophosphate binding site [ion binding]; other site 655816003637 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 655816003638 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 655816003639 thiS-thiF/thiG interaction site; other site 655816003640 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 655816003641 ThiS interaction site; other site 655816003642 putative active site [active] 655816003643 tetramer interface [polypeptide binding]; other site 655816003644 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 655816003645 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 655816003646 ATP binding site [chemical binding]; other site 655816003647 substrate interface [chemical binding]; other site 655816003648 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 655816003649 dimer interface [polypeptide binding]; other site 655816003650 substrate binding site [chemical binding]; other site 655816003651 ATP binding site [chemical binding]; other site 655816003652 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 655816003653 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 655816003654 NAD binding site [chemical binding]; other site 655816003655 homotetramer interface [polypeptide binding]; other site 655816003656 homodimer interface [polypeptide binding]; other site 655816003657 substrate binding site [chemical binding]; other site 655816003658 active site 655816003659 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 655816003660 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 655816003661 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 655816003662 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 655816003663 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 655816003664 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 655816003665 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 655816003666 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 655816003667 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 655816003668 Part of AAA domain; Region: AAA_19; pfam13245 655816003669 AAA domain; Region: AAA_14; pfam13173 655816003670 Family description; Region: UvrD_C_2; pfam13538 655816003671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816003672 Coenzyme A binding pocket [chemical binding]; other site 655816003673 hypothetical protein; Provisional; Region: PRK13679 655816003674 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 655816003675 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 655816003676 Putative esterase; Region: Esterase; pfam00756 655816003677 cystathionine gamma-synthase; Reviewed; Region: PRK08247 655816003678 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 655816003679 homodimer interface [polypeptide binding]; other site 655816003680 substrate-cofactor binding pocket; other site 655816003681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003682 catalytic residue [active] 655816003683 cystathionine beta-lyase; Provisional; Region: PRK08064 655816003684 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 655816003685 homodimer interface [polypeptide binding]; other site 655816003686 substrate-cofactor binding pocket; other site 655816003687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003688 catalytic residue [active] 655816003689 Predicted integral membrane protein [Function unknown]; Region: COG5505 655816003690 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 655816003691 amidase catalytic site [active] 655816003692 Zn binding residues [ion binding]; other site 655816003693 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 655816003694 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 655816003695 Uncharacterized conserved protein [Function unknown]; Region: COG5444 655816003696 Uncharacterized conserved protein [Function unknown]; Region: COG5444 655816003697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816003698 binding surface 655816003699 TPR motif; other site 655816003700 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816003701 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816003702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816003703 binding surface 655816003704 TPR motif; other site 655816003705 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816003706 YolD-like protein; Region: YolD; pfam08863 655816003707 sequence corresponding to manR is present, but is apparently inactivated by frameshift 655816003708 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 655816003709 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 655816003710 active site 655816003711 P-loop; other site 655816003712 phosphorylation site [posttranslational modification] 655816003713 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 655816003714 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655816003715 active site 655816003716 phosphorylation site [posttranslational modification] 655816003717 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 655816003718 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 655816003719 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 655816003720 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 655816003721 Coenzyme A binding pocket [chemical binding]; other site 655816003722 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 655816003723 putative deacylase active site [active] 655816003724 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 655816003725 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 655816003726 UbiA prenyltransferase family; Region: UbiA; pfam01040 655816003727 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 655816003728 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 655816003729 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 655816003730 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 655816003731 NodB motif; other site 655816003732 active site 655816003733 catalytic site [active] 655816003734 Zn binding site [ion binding]; other site 655816003735 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 655816003736 Putative motility protein; Region: YjfB_motility; pfam14070 655816003737 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 655816003738 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 655816003739 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 655816003740 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 655816003741 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 655816003742 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 655816003743 4Fe-4S binding domain; Region: Fer4_6; pfam12837 655816003744 4Fe-4S binding domain; Region: Fer4; pfam00037 655816003745 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 655816003746 [4Fe-4S] binding site [ion binding]; other site 655816003747 molybdopterin cofactor binding site; other site 655816003748 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 655816003749 molybdopterin cofactor binding site; other site 655816003750 Uncharacterized conserved protein [Function unknown]; Region: COG2427 655816003751 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 655816003752 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 655816003753 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 655816003754 nudix motif; other site 655816003755 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 655816003756 Cytochrome P450; Region: p450; cl12078 655816003757 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 655816003758 glycosyltransferase, MGT family; Region: MGT; TIGR01426 655816003759 active site 655816003760 TDP-binding site; other site 655816003761 acceptor substrate-binding pocket; other site 655816003762 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 655816003763 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 655816003764 active site 655816003765 TIGR00245 family protein; Region: TIGR00245 655816003766 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 655816003767 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 655816003768 Walker A/P-loop; other site 655816003769 ATP binding site [chemical binding]; other site 655816003770 Q-loop/lid; other site 655816003771 ABC transporter signature motif; other site 655816003772 Walker B; other site 655816003773 D-loop; other site 655816003774 H-loop/switch region; other site 655816003775 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 655816003776 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 655816003777 Uncharacterized conserved protein [Function unknown]; Region: COG2427 655816003778 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 655816003779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816003780 Glucuronate isomerase; Region: UxaC; pfam02614 655816003781 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 655816003782 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 655816003783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816003784 putative substrate translocation pore; other site 655816003785 Malate/L-lactate dehydrogenase; Region: Ldh_2; pfam02615 655816003786 putative oxidoreductase; Provisional; Region: PRK10083 655816003787 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 655816003788 putative NAD(P) binding site [chemical binding]; other site 655816003789 catalytic Zn binding site [ion binding]; other site 655816003790 structural Zn binding site [ion binding]; other site 655816003791 mannonate dehydratase; Provisional; Region: PRK03906 655816003792 mannonate dehydratase; Region: uxuA; TIGR00695 655816003793 D-mannonate oxidoreductase; Provisional; Region: PRK08277 655816003794 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 655816003795 putative NAD(P) binding site [chemical binding]; other site 655816003796 active site 655816003797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816003798 D-galactonate transporter; Region: 2A0114; TIGR00893 655816003799 putative substrate translocation pore; other site 655816003800 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816003801 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816003802 DNA binding site [nucleotide binding] 655816003803 domain linker motif; other site 655816003804 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 655816003805 dimerization interface [polypeptide binding]; other site 655816003806 ligand binding site [chemical binding]; other site 655816003807 altronate oxidoreductase; Provisional; Region: PRK03643 655816003808 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 655816003809 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 655816003810 galactarate dehydratase; Region: galactar-dH20; TIGR03248 655816003811 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 655816003812 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 655816003813 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 655816003814 DinB family; Region: DinB; pfam05163 655816003815 DinB superfamily; Region: DinB_2; pfam12867 655816003816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816003817 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 655816003818 Walker A motif; other site 655816003819 ATP binding site [chemical binding]; other site 655816003820 Walker B motif; other site 655816003821 arginine finger; other site 655816003822 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816003823 binding surface 655816003824 TPR motif; other site 655816003825 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816003826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816003827 binding surface 655816003828 TPR motif; other site 655816003829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 655816003830 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 655816003831 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 655816003832 amidase catalytic site [active] 655816003833 Zn binding residues [ion binding]; other site 655816003834 substrate binding site [chemical binding]; other site 655816003835 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816003836 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 655816003837 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 655816003838 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 655816003839 pentamer interface [polypeptide binding]; other site 655816003840 dodecaamer interface [polypeptide binding]; other site 655816003841 Phage-related replication protein [General function prediction only]; Region: COG4195 655816003842 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 655816003843 dimanganese center [ion binding]; other site 655816003844 Domain of unknown function (DUF955); Region: DUF955; pfam06114 655816003845 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 655816003846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816003847 non-specific DNA binding site [nucleotide binding]; other site 655816003848 salt bridge; other site 655816003849 sequence-specific DNA binding site [nucleotide binding]; other site 655816003850 hypothetical protein; Provisional; Region: PRK06921 655816003851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816003852 Walker A motif; other site 655816003853 ATP binding site [chemical binding]; other site 655816003854 Walker B motif; other site 655816003855 positive control sigma-like factor; Validated; Region: PRK06930 655816003856 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816003857 DNA binding residues [nucleotide binding] 655816003858 Phage terminase small subunit; Region: Phage_terminase; pfam10668 655816003859 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 655816003860 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 655816003861 Terminase-like family; Region: Terminase_6; pfam03237 655816003862 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 655816003863 Phage capsid family; Region: Phage_capsid; pfam05065 655816003864 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 655816003865 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 655816003866 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 655816003867 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 655816003868 Phage XkdN-like protein; Region: XkdN; pfam08890 655816003869 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 655816003870 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 655816003871 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 655816003872 N-acetyl-D-glucosamine binding site [chemical binding]; other site 655816003873 catalytic residue [active] 655816003874 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 655816003875 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816003876 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 655816003877 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 655816003878 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 655816003879 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 655816003880 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 655816003881 XkdW protein; Region: XkdW; pfam09636 655816003882 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 655816003883 Haemolysin XhlA; Region: XhlA; pfam10779 655816003884 holin, SPP1 family; Region: holin_SPP1; TIGR01592 655816003885 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 655816003886 amidase catalytic site [active] 655816003887 Zn binding residues [ion binding]; other site 655816003888 substrate binding site [chemical binding]; other site 655816003889 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816003890 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 655816003891 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 655816003892 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 655816003893 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 655816003894 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 655816003895 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 655816003896 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 655816003897 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 655816003898 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 655816003899 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816003900 Zn binding site [ion binding]; other site 655816003901 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 655816003902 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816003903 Zn binding site [ion binding]; other site 655816003904 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 655816003905 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 655816003906 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 655816003907 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 655816003908 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 655816003909 Ligand binding site; other site 655816003910 Putative Catalytic site; other site 655816003911 DXD motif; other site 655816003912 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 655816003913 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655816003914 protein binding site [polypeptide binding]; other site 655816003915 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 655816003916 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 655816003917 D-alanyl-aminopeptidase 655816003918 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 655816003919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816003920 dimer interface [polypeptide binding]; other site 655816003921 conserved gate region; other site 655816003922 putative PBP binding loops; other site 655816003923 ABC-ATPase subunit interface; other site 655816003924 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 655816003925 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 655816003926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816003927 dimer interface [polypeptide binding]; other site 655816003928 conserved gate region; other site 655816003929 putative PBP binding loops; other site 655816003930 ABC-ATPase subunit interface; other site 655816003931 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 655816003932 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655816003933 Walker A/P-loop; other site 655816003934 ATP binding site [chemical binding]; other site 655816003935 Q-loop/lid; other site 655816003936 ABC transporter signature motif; other site 655816003937 Walker B; other site 655816003938 D-loop; other site 655816003939 H-loop/switch region; other site 655816003940 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 655816003941 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 655816003942 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 655816003943 peptide binding site [polypeptide binding]; other site 655816003944 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 655816003945 dimer interface [polypeptide binding]; other site 655816003946 catalytic triad [active] 655816003947 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 655816003948 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 655816003949 active site 655816003950 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 655816003951 NlpC/P60 family; Region: NLPC_P60; pfam00877 655816003952 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 655816003953 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655816003954 Walker A/P-loop; other site 655816003955 ATP binding site [chemical binding]; other site 655816003956 Q-loop/lid; other site 655816003957 ABC transporter signature motif; other site 655816003958 Walker B; other site 655816003959 D-loop; other site 655816003960 H-loop/switch region; other site 655816003961 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 655816003962 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 655816003963 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 655816003964 Amidinotransferase; Region: Amidinotransf; pfam02274 655816003965 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 655816003966 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 655816003967 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 655816003968 heme-binding site [chemical binding]; other site 655816003969 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 655816003970 FAD binding pocket [chemical binding]; other site 655816003971 FAD binding motif [chemical binding]; other site 655816003972 phosphate binding motif [ion binding]; other site 655816003973 beta-alpha-beta structure motif; other site 655816003974 NAD binding pocket [chemical binding]; other site 655816003975 Heme binding pocket [chemical binding]; other site 655816003976 Predicted membrane protein [Function unknown]; Region: COG2323 655816003977 DinB superfamily; Region: DinB_2; pfam12867 655816003978 metal-dependent hydrolase; Provisional; Region: PRK13291 655816003979 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816003980 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 655816003981 riboswitch leader; may function to switch on expression of the ykkC efflux pump gene in response to toxic compounds; BSUW23_misc_RNA_16 655816003982 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 655816003983 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 655816003984 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 655816003985 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 655816003986 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 655816003987 putative active site [active] 655816003988 putative substrate binding site [chemical binding]; other site 655816003989 putative cosubstrate binding site; other site 655816003990 catalytic site [active] 655816003991 glutamate 5-kinase; Region: proB; TIGR01027 655816003992 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 655816003993 nucleotide binding site [chemical binding]; other site 655816003994 homotetrameric interface [polypeptide binding]; other site 655816003995 putative phosphate binding site [ion binding]; other site 655816003996 putative allosteric binding site; other site 655816003997 PUA domain; Region: PUA; pfam01472 655816003998 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 655816003999 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 655816004000 putative catalytic cysteine [active] 655816004001 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 655816004002 Transcriptional regulators [Transcription]; Region: MarR; COG1846 655816004003 MarR family; Region: MarR; pfam01047 655816004004 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 655816004005 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 655816004006 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 655816004007 putative metal binding site; other site 655816004008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816004009 binding surface 655816004010 TPR motif; other site 655816004011 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 655816004012 nucleoside/Zn binding site; other site 655816004013 dimer interface [polypeptide binding]; other site 655816004014 catalytic motif [active] 655816004015 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 655816004016 catalytic core [active] 655816004017 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 655816004018 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 655816004019 THF binding site; other site 655816004020 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 655816004021 substrate binding site [chemical binding]; other site 655816004022 THF binding site; other site 655816004023 zinc-binding site [ion binding]; other site 655816004024 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 655816004025 active site 655816004026 catalytic residues [active] 655816004027 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816004028 Cobalt transport protein; Region: CbiQ; pfam02361 655816004029 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 655816004030 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 655816004031 Walker A/P-loop; other site 655816004032 ATP binding site [chemical binding]; other site 655816004033 Q-loop/lid; other site 655816004034 ABC transporter signature motif; other site 655816004035 Walker B; other site 655816004036 D-loop; other site 655816004037 H-loop/switch region; other site 655816004038 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 655816004039 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 655816004040 Walker A/P-loop; other site 655816004041 ATP binding site [chemical binding]; other site 655816004042 Q-loop/lid; other site 655816004043 ABC transporter signature motif; other site 655816004044 Walker B; other site 655816004045 D-loop; other site 655816004046 H-loop/switch region; other site 655816004047 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 655816004048 YKOF-related Family; Region: Ykof; pfam07615 655816004049 YKOF-related Family; Region: Ykof; pfam07615 655816004050 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816004051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816004052 active site 655816004053 phosphorylation site [posttranslational modification] 655816004054 intermolecular recognition site; other site 655816004055 dimerization interface [polypeptide binding]; other site 655816004056 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816004057 DNA binding site [nucleotide binding] 655816004058 HAMP domain; Region: HAMP; pfam00672 655816004059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816004060 dimerization interface [polypeptide binding]; other site 655816004061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816004062 dimer interface [polypeptide binding]; other site 655816004063 phosphorylation site [posttranslational modification] 655816004064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816004065 ATP binding site [chemical binding]; other site 655816004066 Mg2+ binding site [ion binding]; other site 655816004067 G-X-G motif; other site 655816004068 Predicted membrane protein [Function unknown]; Region: COG3212 655816004069 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 655816004070 Predicted membrane protein [Function unknown]; Region: COG3212 655816004071 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 655816004072 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 655816004073 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 655816004074 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 655816004075 MgtE intracellular N domain; Region: MgtE_N; smart00924 655816004076 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 655816004077 Divalent cation transporter; Region: MgtE; pfam01769 655816004078 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 655816004079 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 655816004080 DNA binding residues [nucleotide binding] 655816004081 putative dimer interface [polypeptide binding]; other site 655816004082 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816004083 MarR family; Region: MarR; pfam01047 655816004084 MarR family; Region: MarR_2; cl17246 655816004085 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 655816004086 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 655816004087 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 655816004088 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655816004089 putative active site [active] 655816004090 putative metal binding site [ion binding]; other site 655816004091 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 655816004092 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 655816004093 Ligand binding site; other site 655816004094 Putative Catalytic site; other site 655816004095 DXD motif; other site 655816004096 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 655816004097 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 655816004098 active site 655816004099 DNA binding site [nucleotide binding] 655816004100 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 655816004101 nucleotide binding site [chemical binding]; other site 655816004102 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 655816004103 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 655816004104 putative DNA binding site [nucleotide binding]; other site 655816004105 putative homodimer interface [polypeptide binding]; other site 655816004106 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 655816004107 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 655816004108 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 655816004109 PAS domain; Region: PAS_9; pfam13426 655816004110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655816004111 metal binding site [ion binding]; metal-binding site 655816004112 active site 655816004113 I-site; other site 655816004114 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655816004115 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 655816004116 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 655816004117 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 655816004118 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 655816004119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816004120 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 655816004121 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 655816004122 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 655816004123 heat shock protein HtpX; Provisional; Region: PRK05457 655816004124 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 655816004125 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 655816004126 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 655816004127 Acyltransferase family; Region: Acyl_transf_3; pfam01757 655816004128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816004129 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 655816004130 putative active site [active] 655816004131 heme pocket [chemical binding]; other site 655816004132 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816004133 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 655816004134 putative active site [active] 655816004135 heme pocket [chemical binding]; other site 655816004136 PAS domain; Region: PAS; smart00091 655816004137 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 655816004138 PAS domain; Region: PAS; smart00091 655816004139 putative active site [active] 655816004140 heme pocket [chemical binding]; other site 655816004141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816004142 dimer interface [polypeptide binding]; other site 655816004143 phosphorylation site [posttranslational modification] 655816004144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816004145 ATP binding site [chemical binding]; other site 655816004146 Mg2+ binding site [ion binding]; other site 655816004147 G-X-G motif; other site 655816004148 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 655816004149 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 655816004150 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 655816004151 DNA binding site [nucleotide binding] 655816004152 active site 655816004153 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 655816004154 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 655816004155 Predicted kinase [General function prediction only]; Region: COG4857 655816004156 Phosphotransferase enzyme family; Region: APH; pfam01636 655816004157 Predicted amidohydrolase [General function prediction only]; Region: COG0388 655816004158 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 655816004159 putative active site [active] 655816004160 catalytic triad [active] 655816004161 putative dimer interface [polypeptide binding]; other site 655816004162 transaminase; Reviewed; Region: PRK08068 655816004163 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816004164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816004165 homodimer interface [polypeptide binding]; other site 655816004166 catalytic residue [active] 655816004167 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 655816004168 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 655816004169 dimer interface [polypeptide binding]; other site 655816004170 active site 655816004171 catalytic residue [active] 655816004172 metal binding site [ion binding]; metal-binding site 655816004173 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 655816004174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816004175 motif II; other site 655816004176 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 655816004177 intersubunit interface [polypeptide binding]; other site 655816004178 active site 655816004179 Zn2+ binding site [ion binding]; other site 655816004180 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 655816004181 Cupin domain; Region: Cupin_2; pfam07883 655816004182 Uncharacterized conserved protein [Function unknown]; Region: COG3339 655816004183 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 655816004184 Cache domain; Region: Cache_1; pfam02743 655816004185 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 655816004186 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816004187 dimer interface [polypeptide binding]; other site 655816004188 phosphorylation site [posttranslational modification] 655816004189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816004190 ATP binding site [chemical binding]; other site 655816004191 Mg2+ binding site [ion binding]; other site 655816004192 G-X-G motif; other site 655816004193 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816004194 MarR family; Region: MarR; pfam01047 655816004195 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 655816004196 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 655816004197 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 655816004198 ligand binding site [chemical binding]; other site 655816004199 flagellar motor protein MotA; Validated; Region: PRK08124 655816004200 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 655816004201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816004202 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 655816004203 Walker A motif; other site 655816004204 ATP binding site [chemical binding]; other site 655816004205 Walker B motif; other site 655816004206 arginine finger; other site 655816004207 UvrB/uvrC motif; Region: UVR; pfam02151 655816004208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816004209 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 655816004210 Walker A motif; other site 655816004211 ATP binding site [chemical binding]; other site 655816004212 Walker B motif; other site 655816004213 arginine finger; other site 655816004214 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 655816004215 Uncharacterized membrane protein [Function unknown]; Region: COG3949 655816004216 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 655816004217 Ligand Binding Site [chemical binding]; other site 655816004218 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 655816004219 active site 655816004220 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 655816004221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816004222 FeS/SAM binding site; other site 655816004223 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 655816004224 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 655816004225 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 655816004226 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 655816004227 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 655816004228 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 655816004229 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 655816004230 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 655816004231 catalytic residues [active] 655816004232 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 655816004233 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 655816004234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816004235 motif II; other site 655816004236 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 655816004237 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 655816004238 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 655816004239 active site 655816004240 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816004241 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816004242 DNA binding site [nucleotide binding] 655816004243 domain linker motif; other site 655816004244 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 655816004245 putative dimerization interface [polypeptide binding]; other site 655816004246 putative ligand binding site [chemical binding]; other site 655816004247 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 655816004248 CAT RNA binding domain; Region: CAT_RBD; pfam03123 655816004249 PRD domain; Region: PRD; pfam00874 655816004250 PRD domain; Region: PRD; pfam00874 655816004251 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655816004252 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 655816004253 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816004254 active site turn [active] 655816004255 phosphorylation site [posttranslational modification] 655816004256 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 655816004257 HPr interaction site; other site 655816004258 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655816004259 active site 655816004260 phosphorylation site [posttranslational modification] 655816004261 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 655816004262 dimerization domain swap beta strand [polypeptide binding]; other site 655816004263 regulatory protein interface [polypeptide binding]; other site 655816004264 active site 655816004265 regulatory phosphorylation site [posttranslational modification]; other site 655816004266 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 655816004267 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 655816004268 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 655816004269 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 655816004270 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 655816004271 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 655816004272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816004273 FeS/SAM binding site; other site 655816004274 putative acetyltransferase; Provisional; Region: PRK03624 655816004275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816004276 Coenzyme A binding pocket [chemical binding]; other site 655816004277 Cache domain; Region: Cache_1; pfam02743 655816004278 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816004279 dimerization interface [polypeptide binding]; other site 655816004280 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816004281 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816004282 dimer interface [polypeptide binding]; other site 655816004283 putative CheW interface [polypeptide binding]; other site 655816004284 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 655816004285 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 655816004286 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 655816004287 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 655816004288 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816004289 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816004290 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 655816004291 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 655816004292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816004293 putative active site [active] 655816004294 heme pocket [chemical binding]; other site 655816004295 PAS fold; Region: PAS; pfam00989 655816004296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816004297 putative active site [active] 655816004298 heme pocket [chemical binding]; other site 655816004299 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 655816004300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816004301 putative active site [active] 655816004302 heme pocket [chemical binding]; other site 655816004303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816004304 dimer interface [polypeptide binding]; other site 655816004305 phosphorylation site [posttranslational modification] 655816004306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816004307 ATP binding site [chemical binding]; other site 655816004308 Mg2+ binding site [ion binding]; other site 655816004309 G-X-G motif; other site 655816004310 aminotransferase A; Validated; Region: PRK07683 655816004311 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816004312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816004313 homodimer interface [polypeptide binding]; other site 655816004314 catalytic residue [active] 655816004315 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 655816004316 putative CheA interaction surface; other site 655816004317 Response regulator receiver domain; Region: Response_reg; pfam00072 655816004318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816004319 active site 655816004320 phosphorylation site [posttranslational modification] 655816004321 intermolecular recognition site; other site 655816004322 dimerization interface [polypeptide binding]; other site 655816004323 YkyB-like protein; Region: YkyB; pfam14177 655816004324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816004325 H+ Antiporter protein; Region: 2A0121; TIGR00900 655816004326 putative substrate translocation pore; other site 655816004327 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816004328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 655816004329 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 655816004330 phosphodiesterase YaeI; Provisional; Region: PRK11340 655816004331 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 655816004332 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 655816004333 putative active site [active] 655816004334 putative metal binding site [ion binding]; other site 655816004335 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 655816004336 short chain dehydrogenase; Provisional; Region: PRK07677 655816004337 NAD(P) binding site [chemical binding]; other site 655816004338 substrate binding site [chemical binding]; other site 655816004339 homotetramer interface [polypeptide binding]; other site 655816004340 active site 655816004341 homodimer interface [polypeptide binding]; other site 655816004342 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655816004343 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 655816004344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 655816004345 Protein of unknown function (DUF458); Region: DUF458; pfam04308 655816004346 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 655816004347 FOG: CBS domain [General function prediction only]; Region: COG0517 655816004348 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 655816004349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816004350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816004351 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655816004352 dimerization interface [polypeptide binding]; other site 655816004353 flavodoxin; Provisional; Region: PRK06703 655816004354 VPS10 domain; Region: VPS10; smart00602 655816004355 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 655816004356 flavodoxin, short chain; Region: flav_short; TIGR01753 655816004357 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 655816004358 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 655816004359 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 655816004360 active site 655816004361 trimer interface [polypeptide binding]; other site 655816004362 substrate binding site [chemical binding]; other site 655816004363 CoA binding site [chemical binding]; other site 655816004364 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 655816004365 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 655816004366 metal binding site [ion binding]; metal-binding site 655816004367 putative dimer interface [polypeptide binding]; other site 655816004368 hypothetical protein; Provisional; Region: PRK03094 655816004369 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 655816004370 Mechanosensitive ion channel; Region: MS_channel; pfam00924 655816004371 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 655816004372 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 655816004373 dimer interface [polypeptide binding]; other site 655816004374 decamer (pentamer of dimers) interface [polypeptide binding]; other site 655816004375 catalytic triad [active] 655816004376 peroxidatic and resolving cysteines [active] 655816004377 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 655816004378 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 655816004379 catalytic residues [active] 655816004380 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 655816004381 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 655816004382 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 655816004383 GTP binding site; other site 655816004384 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 655816004385 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 655816004386 ATP binding site [chemical binding]; other site 655816004387 substrate interface [chemical binding]; other site 655816004388 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 655816004389 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 655816004390 dimer interface [polypeptide binding]; other site 655816004391 putative functional site; other site 655816004392 putative MPT binding site; other site 655816004393 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 655816004394 Walker A motif; other site 655816004395 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 655816004396 MoaE homodimer interface [polypeptide binding]; other site 655816004397 MoaD interaction [polypeptide binding]; other site 655816004398 active site residues [active] 655816004399 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 655816004400 MoaE interaction surface [polypeptide binding]; other site 655816004401 MoeB interaction surface [polypeptide binding]; other site 655816004402 thiocarboxylated glycine; other site 655816004403 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816004404 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655816004405 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 655816004406 Walker A/P-loop; other site 655816004407 ATP binding site [chemical binding]; other site 655816004408 Q-loop/lid; other site 655816004409 ABC transporter signature motif; other site 655816004410 Walker B; other site 655816004411 D-loop; other site 655816004412 H-loop/switch region; other site 655816004413 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816004414 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655816004415 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 655816004416 Walker A/P-loop; other site 655816004417 ATP binding site [chemical binding]; other site 655816004418 Q-loop/lid; other site 655816004419 ABC transporter signature motif; other site 655816004420 Walker B; other site 655816004421 D-loop; other site 655816004422 H-loop/switch region; other site 655816004423 Yip1 domain; Region: Yip1; pfam04893 655816004424 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 655816004425 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655816004426 HlyD family secretion protein; Region: HlyD_3; pfam13437 655816004427 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816004428 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 655816004429 Walker A/P-loop; other site 655816004430 ATP binding site [chemical binding]; other site 655816004431 Q-loop/lid; other site 655816004432 ABC transporter signature motif; other site 655816004433 Walker B; other site 655816004434 D-loop; other site 655816004435 H-loop/switch region; other site 655816004436 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 655816004437 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 655816004438 FtsX-like permease family; Region: FtsX; pfam02687 655816004439 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655816004440 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 655816004441 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655816004442 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 655816004443 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 655816004444 putative substrate binding site [chemical binding]; other site 655816004445 putative ATP binding site [chemical binding]; other site 655816004446 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 655816004447 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655816004448 active site 655816004449 phosphorylation site [posttranslational modification] 655816004450 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 655816004451 active site 655816004452 P-loop; other site 655816004453 phosphorylation site [posttranslational modification] 655816004454 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 655816004455 Homeodomain-like domain; Region: HTH_23; pfam13384 655816004456 putative transposase OrfB; Reviewed; Region: PHA02517 655816004457 HTH-like domain; Region: HTH_21; pfam13276 655816004458 Integrase core domain; Region: rve; pfam00665 655816004459 Integrase core domain; Region: rve_3; pfam13683 655816004460 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 655816004461 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 655816004462 Catalytic site [active] 655816004463 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 655816004464 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655816004465 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655816004466 ABC transporter; Region: ABC_tran_2; pfam12848 655816004467 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655816004468 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 655816004469 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 655816004470 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 655816004471 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 655816004472 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 655816004473 rod-share determining protein MreBH; Provisional; Region: PRK13929 655816004474 MreB and similar proteins; Region: MreB_like; cd10225 655816004475 nucleotide binding site [chemical binding]; other site 655816004476 Mg binding site [ion binding]; other site 655816004477 putative protofilament interaction site [polypeptide binding]; other site 655816004478 RodZ interaction site [polypeptide binding]; other site 655816004479 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 655816004480 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 655816004481 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 655816004482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816004483 putative active site [active] 655816004484 heme pocket [chemical binding]; other site 655816004485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816004486 dimer interface [polypeptide binding]; other site 655816004487 phosphorylation site [posttranslational modification] 655816004488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816004489 ATP binding site [chemical binding]; other site 655816004490 Mg2+ binding site [ion binding]; other site 655816004491 G-X-G motif; other site 655816004492 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 655816004493 putative active site pocket [active] 655816004494 dimerization interface [polypeptide binding]; other site 655816004495 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 655816004496 putative active site pocket [active] 655816004497 dimerization interface [polypeptide binding]; other site 655816004498 putative catalytic residue [active] 655816004499 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 655816004500 TrkA-N domain; Region: TrkA_N; pfam02254 655816004501 TrkA-C domain; Region: TrkA_C; pfam02080 655816004502 adenine deaminase; Region: ade; TIGR01178 655816004503 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 655816004504 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 655816004505 active site 655816004506 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 655816004507 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 655816004508 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 655816004509 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 655816004510 hypothetical protein; Provisional; Region: PRK13667 655816004511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816004512 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 655816004513 active site 655816004514 motif I; other site 655816004515 motif II; other site 655816004516 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816004517 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 655816004518 active site 655816004519 catalytic residues [active] 655816004520 metal binding site [ion binding]; metal-binding site 655816004521 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 655816004522 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 655816004523 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 655816004524 TPP-binding site [chemical binding]; other site 655816004525 tetramer interface [polypeptide binding]; other site 655816004526 heterodimer interface [polypeptide binding]; other site 655816004527 phosphorylation loop region [posttranslational modification] 655816004528 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 655816004529 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 655816004530 alpha subunit interface [polypeptide binding]; other site 655816004531 TPP binding site [chemical binding]; other site 655816004532 heterodimer interface [polypeptide binding]; other site 655816004533 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655816004534 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 655816004535 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 655816004536 E3 interaction surface; other site 655816004537 lipoyl attachment site [posttranslational modification]; other site 655816004538 e3 binding domain; Region: E3_binding; pfam02817 655816004539 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 655816004540 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 655816004541 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 655816004542 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816004543 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 655816004544 Homeodomain-like domain; Region: HTH_23; pfam13384 655816004545 putative transposase OrfB; Reviewed; Region: PHA02517 655816004546 HTH-like domain; Region: HTH_21; pfam13276 655816004547 Integrase core domain; Region: rve; pfam00665 655816004548 Integrase core domain; Region: rve_3; cl15866 655816004549 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 655816004550 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 655816004551 homodimer interface [polypeptide binding]; other site 655816004552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816004553 catalytic residue [active] 655816004554 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 655816004555 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 655816004556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 655816004557 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 655816004558 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 655816004559 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 655816004560 active site 655816004561 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 655816004562 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 655816004563 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 655816004564 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 655816004565 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 655816004566 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 655816004567 active site 655816004568 Zn binding site [ion binding]; other site 655816004569 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816004570 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 655816004571 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816004572 DNA binding residues [nucleotide binding] 655816004573 Putative zinc-finger; Region: zf-HC2; pfam13490 655816004574 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 655816004575 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 655816004576 G1 box; other site 655816004577 putative GEF interaction site [polypeptide binding]; other site 655816004578 GTP/Mg2+ binding site [chemical binding]; other site 655816004579 Switch I region; other site 655816004580 G2 box; other site 655816004581 G3 box; other site 655816004582 Switch II region; other site 655816004583 G4 box; other site 655816004584 G5 box; other site 655816004585 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 655816004586 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 655816004587 YlaH-like protein; Region: YlaH; pfam14036 655816004588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 655816004589 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 655816004590 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 655816004591 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 655816004592 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 655816004593 putative active site [active] 655816004594 PhoH-like protein; Region: PhoH; pfam02562 655816004595 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 655816004596 glutaminase A; Region: Gln_ase; TIGR03814 655816004597 hypothetical protein; Provisional; Region: PRK13666 655816004598 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 655816004599 pyruvate carboxylase; Reviewed; Region: PRK12999 655816004600 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816004601 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 655816004602 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 655816004603 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 655816004604 active site 655816004605 catalytic residues [active] 655816004606 metal binding site [ion binding]; metal-binding site 655816004607 homodimer binding site [polypeptide binding]; other site 655816004608 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 655816004609 carboxyltransferase (CT) interaction site; other site 655816004610 biotinylation site [posttranslational modification]; other site 655816004611 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 655816004612 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 655816004613 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 655816004614 UbiA prenyltransferase family; Region: UbiA; pfam01040 655816004615 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 655816004616 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 655816004617 Cytochrome c; Region: Cytochrom_C; pfam00034 655816004618 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 655816004619 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 655816004620 D-pathway; other site 655816004621 Putative ubiquinol binding site [chemical binding]; other site 655816004622 Low-spin heme (heme b) binding site [chemical binding]; other site 655816004623 Putative water exit pathway; other site 655816004624 Binuclear center (heme o3/CuB) [ion binding]; other site 655816004625 K-pathway; other site 655816004626 Putative proton exit pathway; other site 655816004627 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 655816004628 Subunit I/III interface [polypeptide binding]; other site 655816004629 Subunit III/IV interface [polypeptide binding]; other site 655816004630 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 655816004631 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 655816004632 YugN-like family; Region: YugN; pfam08868 655816004633 FOG: CBS domain [General function prediction only]; Region: COG0517 655816004634 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 655816004635 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 655816004636 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 655816004637 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 655816004638 Putative coat protein; Region: YlbD_coat; pfam14071 655816004639 YlbE-like protein; Region: YlbE; pfam14003 655816004640 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 655816004641 hypothetical protein; Provisional; Region: PRK02886 655816004642 ylbH leader; regulatory RNA structure (riboswitch) potentially involved in regulation of ylbH; BSUW23_misc_RNA_23 655816004643 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 655816004644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816004645 S-adenosylmethionine binding site [chemical binding]; other site 655816004646 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 655816004647 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 655816004648 active site 655816004649 (T/H)XGH motif; other site 655816004650 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 655816004651 Nucleoside recognition; Region: Gate; pfam07670 655816004652 Nucleoside recognition; Region: Gate; pfam07670 655816004653 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 655816004654 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 655816004655 nucleophile elbow; other site 655816004656 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 655816004657 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 655816004658 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 655816004659 protein binding site [polypeptide binding]; other site 655816004660 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 655816004661 hypothetical protein; Provisional; Region: PRK13670 655816004662 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 655816004663 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 655816004664 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 655816004665 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 655816004666 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 655816004667 hypothetical protein; Provisional; Region: PRK13688 655816004668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816004669 Coenzyme A binding pocket [chemical binding]; other site 655816004670 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 655816004671 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 655816004672 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 655816004673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 655816004674 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 655816004675 mraZ protein; Region: TIGR00242 655816004676 MraZ protein; Region: MraZ; pfam02381 655816004677 MraZ protein; Region: MraZ; pfam02381 655816004678 MraW methylase family; Region: Methyltransf_5; pfam01795 655816004679 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 655816004680 Cell division protein FtsL; Region: FtsL; cl11433 655816004681 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 655816004682 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816004683 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 655816004684 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 655816004685 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 655816004686 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 655816004687 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816004688 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 655816004689 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 655816004690 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 655816004691 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 655816004692 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655816004693 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655816004694 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 655816004695 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 655816004696 Mg++ binding site [ion binding]; other site 655816004697 putative catalytic motif [active] 655816004698 putative substrate binding site [chemical binding]; other site 655816004699 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 655816004700 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655816004701 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655816004702 stage V sporulation protein E; Region: spoVE; TIGR02615 655816004703 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 655816004704 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 655816004705 active site 655816004706 homodimer interface [polypeptide binding]; other site 655816004707 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 655816004708 FAD binding domain; Region: FAD_binding_4; pfam01565 655816004709 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 655816004710 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 655816004711 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 655816004712 Cell division protein FtsQ; Region: FtsQ; pfam03799 655816004713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 655816004714 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 655816004715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 655816004716 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 655816004717 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 655816004718 cell division protein FtsA; Region: ftsA; TIGR01174 655816004719 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655816004720 nucleotide binding site [chemical binding]; other site 655816004721 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 655816004722 Cell division protein FtsA; Region: FtsA; pfam14450 655816004723 cell division protein FtsZ; Validated; Region: PRK09330 655816004724 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 655816004725 nucleotide binding site [chemical binding]; other site 655816004726 SulA interaction site; other site 655816004727 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 655816004728 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 655816004729 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 655816004730 active site 655816004731 catalytic triad [active] 655816004732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 655816004733 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 655816004734 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 655816004735 Cna protein B-type domain; Region: Cna_B_2; pfam13715 655816004736 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 655816004737 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 655816004738 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 655816004739 sporulation sigma factor SigE; Reviewed; Region: PRK08301 655816004740 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816004741 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816004742 DNA binding residues [nucleotide binding] 655816004743 sporulation sigma factor SigG; Reviewed; Region: PRK08215 655816004744 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816004745 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 655816004746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816004747 DNA binding residues [nucleotide binding] 655816004748 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655816004749 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 655816004750 Walker A/P-loop; other site 655816004751 ATP binding site [chemical binding]; other site 655816004752 Q-loop/lid; other site 655816004753 ABC transporter signature motif; other site 655816004754 Walker B; other site 655816004755 D-loop; other site 655816004756 H-loop/switch region; other site 655816004757 acetylornithine deacetylase; Validated; Region: PRK08596 655816004758 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 655816004759 metal binding site [ion binding]; metal-binding site 655816004760 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 655816004761 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 655816004762 uncharacterized protein, YfiH family; Region: TIGR00726 655816004763 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 655816004764 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655816004765 catalytic residue [active] 655816004766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 655816004767 YGGT family; Region: YGGT; pfam02325 655816004768 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 655816004769 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816004770 RNA binding surface [nucleotide binding]; other site 655816004771 DivIVA protein; Region: DivIVA; pfam05103 655816004772 DivIVA domain; Region: DivI1A_domain; TIGR03544 655816004773 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 655816004774 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 655816004775 HIGH motif; other site 655816004776 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 655816004777 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 655816004778 active site 655816004779 KMSKS motif; other site 655816004780 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 655816004781 tRNA binding surface [nucleotide binding]; other site 655816004782 anticodon binding site; other site 655816004783 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 655816004784 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 655816004785 lipoprotein signal peptidase; Provisional; Region: PRK14787 655816004786 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 655816004787 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816004788 RNA binding surface [nucleotide binding]; other site 655816004789 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 655816004790 active site 655816004791 pyrR leader; transcriptional attenuator structure and binding site for PyrR regulator; BSUW23_misc_RNA_26 655816004792 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 655816004793 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816004794 active site 655816004795 pyrP leader; transcriptional attenuator structure and binding site for PyrR regulator; BSUW23_misc_RNA_27 655816004796 uracil-xanthine permease; Region: ncs2; TIGR00801 655816004797 pyrB leader; transcriptional attenuator structure and binding site for PyrR regulator; BSUW23_misc_RNA_28 655816004798 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 655816004799 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 655816004800 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 655816004801 dihydroorotase; Validated; Region: pyrC; PRK09357 655816004802 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 655816004803 active site 655816004804 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 655816004805 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 655816004806 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 655816004807 catalytic site [active] 655816004808 subunit interface [polypeptide binding]; other site 655816004809 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 655816004810 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816004811 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 655816004812 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 655816004813 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816004814 ATP-grasp domain; Region: ATP-grasp_4; cl17255 655816004815 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 655816004816 IMP binding site; other site 655816004817 dimer interface [polypeptide binding]; other site 655816004818 interdomain contacts; other site 655816004819 partial ornithine binding site; other site 655816004820 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 655816004821 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 655816004822 FAD binding pocket [chemical binding]; other site 655816004823 FAD binding motif [chemical binding]; other site 655816004824 phosphate binding motif [ion binding]; other site 655816004825 beta-alpha-beta structure motif; other site 655816004826 NAD binding pocket [chemical binding]; other site 655816004827 Iron coordination center [ion binding]; other site 655816004828 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 655816004829 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 655816004830 heterodimer interface [polypeptide binding]; other site 655816004831 active site 655816004832 FMN binding site [chemical binding]; other site 655816004833 homodimer interface [polypeptide binding]; other site 655816004834 substrate binding site [chemical binding]; other site 655816004835 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 655816004836 active site 655816004837 dimer interface [polypeptide binding]; other site 655816004838 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816004839 active site 655816004840 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 655816004841 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 655816004842 Active Sites [active] 655816004843 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 655816004844 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 655816004845 ATP-sulfurylase; Region: ATPS; cd00517 655816004846 active site 655816004847 HXXH motif; other site 655816004848 flexible loop; other site 655816004849 AAA domain; Region: AAA_33; pfam13671 655816004850 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 655816004851 ligand-binding site [chemical binding]; other site 655816004852 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 655816004853 diphthine synthase; Region: dph5; TIGR00522 655816004854 active site 655816004855 SAM binding site [chemical binding]; other site 655816004856 homodimer interface [polypeptide binding]; other site 655816004857 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 655816004858 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 655816004859 putative active site [active] 655816004860 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 655816004861 putative active site [active] 655816004862 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 655816004863 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 655816004864 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 655816004865 Domain of unknown function (DUF814); Region: DUF814; pfam05670 655816004866 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 655816004867 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 655816004868 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 655816004869 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 655816004870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816004871 motif II; other site 655816004872 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 655816004873 TIGR00255 family protein; Region: TIGR00255 655816004874 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 655816004875 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 655816004876 hypothetical protein; Provisional; Region: PRK04323 655816004877 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 655816004878 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 655816004879 catalytic site [active] 655816004880 G-X2-G-X-G-K; other site 655816004881 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 655816004882 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 655816004883 Flavoprotein; Region: Flavoprotein; pfam02441 655816004884 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 655816004885 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 655816004886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816004887 ATP binding site [chemical binding]; other site 655816004888 putative Mg++ binding site [ion binding]; other site 655816004889 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816004890 nucleotide binding region [chemical binding]; other site 655816004891 ATP-binding site [chemical binding]; other site 655816004892 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 655816004893 active site 655816004894 catalytic residues [active] 655816004895 metal binding site [ion binding]; metal-binding site 655816004896 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 655816004897 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 655816004898 putative active site [active] 655816004899 substrate binding site [chemical binding]; other site 655816004900 putative cosubstrate binding site; other site 655816004901 catalytic site [active] 655816004902 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 655816004903 substrate binding site [chemical binding]; other site 655816004904 16S rRNA methyltransferase B; Provisional; Region: PRK14902 655816004905 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 655816004906 putative RNA binding site [nucleotide binding]; other site 655816004907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816004908 S-adenosylmethionine binding site [chemical binding]; other site 655816004909 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 655816004910 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816004911 FeS/SAM binding site; other site 655816004912 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 655816004913 Protein phosphatase 2C; Region: PP2C; pfam00481 655816004914 active site 655816004915 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816004916 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 655816004917 active site 655816004918 ATP binding site [chemical binding]; other site 655816004919 substrate binding site [chemical binding]; other site 655816004920 activation loop (A-loop); other site 655816004921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 655816004922 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 655816004923 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 655816004924 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 655816004925 GTPase RsgA; Reviewed; Region: PRK00098 655816004926 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 655816004927 RNA binding site [nucleotide binding]; other site 655816004928 homodimer interface [polypeptide binding]; other site 655816004929 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 655816004930 GTPase/Zn-binding domain interface [polypeptide binding]; other site 655816004931 GTP/Mg2+ binding site [chemical binding]; other site 655816004932 G4 box; other site 655816004933 G5 box; other site 655816004934 G1 box; other site 655816004935 Switch I region; other site 655816004936 G2 box; other site 655816004937 G3 box; other site 655816004938 Switch II region; other site 655816004939 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 655816004940 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 655816004941 substrate binding site [chemical binding]; other site 655816004942 hexamer interface [polypeptide binding]; other site 655816004943 metal binding site [ion binding]; metal-binding site 655816004944 Thiamine pyrophosphokinase; Region: TPK; cd07995 655816004945 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 655816004946 active site 655816004947 dimerization interface [polypeptide binding]; other site 655816004948 thiamine binding site [chemical binding]; other site 655816004949 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 655816004950 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 655816004951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 655816004952 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 655816004953 DAK2 domain; Region: Dak2; pfam02734 655816004954 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 655816004955 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 655816004956 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 655816004957 putative L-serine binding site [chemical binding]; other site 655816004958 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Region: sda_alpha; TIGR00718 655816004959 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 655816004960 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 655816004961 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 655816004962 generic binding surface II; other site 655816004963 ssDNA binding site; other site 655816004964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816004965 ATP binding site [chemical binding]; other site 655816004966 putative Mg++ binding site [ion binding]; other site 655816004967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816004968 nucleotide binding region [chemical binding]; other site 655816004969 ATP-binding site [chemical binding]; other site 655816004970 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 655816004971 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 655816004972 putative phosphate acyltransferase; Provisional; Region: PRK05331 655816004973 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 655816004974 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655816004975 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 655816004976 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 655816004977 NAD(P) binding site [chemical binding]; other site 655816004978 homotetramer interface [polypeptide binding]; other site 655816004979 homodimer interface [polypeptide binding]; other site 655816004980 active site 655816004981 acyl carrier protein; Provisional; Region: acpP; PRK00982 655816004982 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 655816004983 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 655816004984 dimerization interface [polypeptide binding]; other site 655816004985 active site 655816004986 metal binding site [ion binding]; metal-binding site 655816004987 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 655816004988 dsRNA binding site [nucleotide binding]; other site 655816004989 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 655816004990 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 655816004991 Walker A/P-loop; other site 655816004992 ATP binding site [chemical binding]; other site 655816004993 Q-loop/lid; other site 655816004994 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 655816004995 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 655816004996 ABC transporter signature motif; other site 655816004997 Walker B; other site 655816004998 D-loop; other site 655816004999 H-loop/switch region; other site 655816005000 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 655816005001 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 655816005002 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 655816005003 GTP binding site [chemical binding]; other site 655816005004 Homeodomain-like domain; Region: HTH_23; pfam13384 655816005005 putative transposase OrfB; Reviewed; Region: PHA02517 655816005006 HTH-like domain; Region: HTH_21; pfam13276 655816005007 Integrase core domain; Region: rve; pfam00665 655816005008 Integrase core domain; Region: rve_3; cl15866 655816005009 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 655816005010 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 655816005011 putative DNA-binding protein; Validated; Region: PRK00118 655816005012 signal recognition particle protein; Provisional; Region: PRK10867 655816005013 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 655816005014 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 655816005015 P loop; other site 655816005016 GTP binding site [chemical binding]; other site 655816005017 Signal peptide binding domain; Region: SRP_SPB; pfam02978 655816005018 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 655816005019 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 655816005020 KH domain; Region: KH_4; pfam13083 655816005021 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 655816005022 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 655816005023 RimM N-terminal domain; Region: RimM; pfam01782 655816005024 PRC-barrel domain; Region: PRC; pfam05239 655816005025 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 655816005026 L19 leader; ribosomal protein gene, untranslated leader; autoregulatory structure; BSUW23_misc_RNA_30 655816005027 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 655816005028 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 655816005029 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 655816005030 GTP/Mg2+ binding site [chemical binding]; other site 655816005031 G4 box; other site 655816005032 G5 box; other site 655816005033 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 655816005034 G1 box; other site 655816005035 G1 box; other site 655816005036 GTP/Mg2+ binding site [chemical binding]; other site 655816005037 Switch I region; other site 655816005038 G2 box; other site 655816005039 G2 box; other site 655816005040 G3 box; other site 655816005041 G3 box; other site 655816005042 Switch II region; other site 655816005043 Switch II region; other site 655816005044 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 655816005045 RNA/DNA hybrid binding site [nucleotide binding]; other site 655816005046 active site 655816005047 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 655816005048 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 655816005049 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 655816005050 CoA-ligase; Region: Ligase_CoA; pfam00549 655816005051 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 655816005052 CoA binding domain; Region: CoA_binding; smart00881 655816005053 CoA-ligase; Region: Ligase_CoA; pfam00549 655816005054 DNA protecting protein DprA; Region: dprA; TIGR00732 655816005055 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 655816005056 DNA topoisomerase I; Validated; Region: PRK05582 655816005057 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 655816005058 active site 655816005059 interdomain interaction site; other site 655816005060 putative metal-binding site [ion binding]; other site 655816005061 nucleotide binding site [chemical binding]; other site 655816005062 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 655816005063 domain I; other site 655816005064 DNA binding groove [nucleotide binding] 655816005065 phosphate binding site [ion binding]; other site 655816005066 domain II; other site 655816005067 domain III; other site 655816005068 nucleotide binding site [chemical binding]; other site 655816005069 catalytic site [active] 655816005070 domain IV; other site 655816005071 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 655816005072 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 655816005073 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 655816005074 Glucose inhibited division protein A; Region: GIDA; pfam01134 655816005075 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 655816005076 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 655816005077 active site 655816005078 Int/Topo IB signature motif; other site 655816005079 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 655816005080 active site 655816005081 HslU subunit interaction site [polypeptide binding]; other site 655816005082 sequence realted to clpY is present, but appears to have been inactivated by a small internal deletion causing a frameshift 655816005083 transcriptional repressor CodY; Validated; Region: PRK04158 655816005084 CodY GAF-like domain; Region: CodY; pfam06018 655816005085 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 655816005086 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 655816005087 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 655816005088 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 655816005089 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 655816005090 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 655816005091 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 655816005092 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 655816005093 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 655816005094 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 655816005095 flagellar motor switch protein FliG; Region: fliG; TIGR00207 655816005096 MgtE intracellular N domain; Region: MgtE_N; smart00924 655816005097 FliG C-terminal domain; Region: FliG_C; pfam01706 655816005098 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 655816005099 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 655816005100 Flagellar assembly protein FliH; Region: FliH; pfam02108 655816005101 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 655816005102 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 655816005103 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 655816005104 Walker A motif/ATP binding site; other site 655816005105 Walker B motif; other site 655816005106 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 655816005107 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 655816005108 Uncharacterized conserved protein [Function unknown]; Region: COG3334 655816005109 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 655816005110 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 655816005111 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 655816005112 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 655816005113 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 655816005114 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 655816005115 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 655816005116 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 655816005117 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 655816005118 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 655816005119 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 655816005120 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 655816005121 flagellar motor switch protein; Validated; Region: PRK08119 655816005122 CheC-like family; Region: CheC; pfam04509 655816005123 CheC-like family; Region: CheC; pfam04509 655816005124 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 655816005125 Response regulator receiver domain; Region: Response_reg; pfam00072 655816005126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816005127 active site 655816005128 phosphorylation site [posttranslational modification] 655816005129 intermolecular recognition site; other site 655816005130 dimerization interface [polypeptide binding]; other site 655816005131 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 655816005132 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 655816005133 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 655816005134 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 655816005135 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 655816005136 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 655816005137 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 655816005138 FHIPEP family; Region: FHIPEP; pfam00771 655816005139 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 655816005140 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 655816005141 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 655816005142 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 655816005143 P-loop; other site 655816005144 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 655816005145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816005146 active site 655816005147 phosphorylation site [posttranslational modification] 655816005148 intermolecular recognition site; other site 655816005149 dimerization interface [polypeptide binding]; other site 655816005150 CheB methylesterase; Region: CheB_methylest; pfam01339 655816005151 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 655816005152 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 655816005153 putative binding surface; other site 655816005154 active site 655816005155 P2 response regulator binding domain; Region: P2; pfam07194 655816005156 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 655816005157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816005158 ATP binding site [chemical binding]; other site 655816005159 Mg2+ binding site [ion binding]; other site 655816005160 G-X-G motif; other site 655816005161 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 655816005162 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 655816005163 putative CheA interaction surface; other site 655816005164 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 655816005165 CheC-like family; Region: CheC; pfam04509 655816005166 CheC-like family; Region: CheC; pfam04509 655816005167 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 655816005168 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 655816005169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816005170 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 655816005171 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816005172 DNA binding residues [nucleotide binding] 655816005173 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 655816005174 rRNA interaction site [nucleotide binding]; other site 655816005175 S8 interaction site; other site 655816005176 putative laminin-1 binding site; other site 655816005177 elongation factor Ts; Provisional; Region: tsf; PRK09377 655816005178 UBA/TS-N domain; Region: UBA; pfam00627 655816005179 Elongation factor TS; Region: EF_TS; pfam00889 655816005180 Elongation factor TS; Region: EF_TS; pfam00889 655816005181 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 655816005182 putative nucleotide binding site [chemical binding]; other site 655816005183 uridine monophosphate binding site [chemical binding]; other site 655816005184 homohexameric interface [polypeptide binding]; other site 655816005185 ribosome recycling factor; Reviewed; Region: frr; PRK00083 655816005186 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 655816005187 hinge region; other site 655816005188 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 655816005189 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 655816005190 catalytic residue [active] 655816005191 putative FPP diphosphate binding site; other site 655816005192 putative FPP binding hydrophobic cleft; other site 655816005193 dimer interface [polypeptide binding]; other site 655816005194 putative IPP diphosphate binding site; other site 655816005195 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 655816005196 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 655816005197 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 655816005198 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 655816005199 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 655816005200 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 655816005201 RIP metalloprotease RseP; Region: TIGR00054 655816005202 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 655816005203 active site 655816005204 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 655816005205 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 655816005206 protein binding site [polypeptide binding]; other site 655816005207 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 655816005208 putative substrate binding region [chemical binding]; other site 655816005209 prolyl-tRNA synthetase; Provisional; Region: PRK09194 655816005210 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 655816005211 dimer interface [polypeptide binding]; other site 655816005212 motif 1; other site 655816005213 active site 655816005214 motif 2; other site 655816005215 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 655816005216 putative deacylase active site [active] 655816005217 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 655816005218 active site 655816005219 motif 3; other site 655816005220 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 655816005221 anticodon binding site; other site 655816005222 DNA polymerase III PolC; Validated; Region: polC; PRK00448 655816005223 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 655816005224 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 655816005225 generic binding surface II; other site 655816005226 generic binding surface I; other site 655816005227 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 655816005228 active site 655816005229 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 655816005230 active site 655816005231 catalytic site [active] 655816005232 substrate binding site [chemical binding]; other site 655816005233 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 655816005234 ribosome maturation protein RimP; Reviewed; Region: PRK00092 655816005235 Sm and related proteins; Region: Sm_like; cl00259 655816005236 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 655816005237 putative oligomer interface [polypeptide binding]; other site 655816005238 putative RNA binding site [nucleotide binding]; other site 655816005239 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 655816005240 NusA N-terminal domain; Region: NusA_N; pfam08529 655816005241 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 655816005242 RNA binding site [nucleotide binding]; other site 655816005243 homodimer interface [polypeptide binding]; other site 655816005244 NusA-like KH domain; Region: KH_5; pfam13184 655816005245 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 655816005246 G-X-X-G motif; other site 655816005247 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 655816005248 putative RNA binding cleft [nucleotide binding]; other site 655816005249 hypothetical protein; Provisional; Region: PRK07714 655816005250 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 655816005251 translation initiation factor IF-2; Region: IF-2; TIGR00487 655816005252 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 655816005253 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 655816005254 G1 box; other site 655816005255 putative GEF interaction site [polypeptide binding]; other site 655816005256 GTP/Mg2+ binding site [chemical binding]; other site 655816005257 Switch I region; other site 655816005258 G2 box; other site 655816005259 G3 box; other site 655816005260 Switch II region; other site 655816005261 G4 box; other site 655816005262 G5 box; other site 655816005263 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 655816005264 Translation-initiation factor 2; Region: IF-2; pfam11987 655816005265 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 655816005266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 655816005267 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 655816005268 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 655816005269 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 655816005270 RNA binding site [nucleotide binding]; other site 655816005271 active site 655816005272 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 655816005273 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 655816005274 active site 655816005275 Riboflavin kinase; Region: Flavokinase; smart00904 655816005276 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 655816005277 16S/18S rRNA binding site [nucleotide binding]; other site 655816005278 S13e-L30e interaction site [polypeptide binding]; other site 655816005279 25S rRNA binding site [nucleotide binding]; other site 655816005280 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 655816005281 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 655816005282 RNase E interface [polypeptide binding]; other site 655816005283 trimer interface [polypeptide binding]; other site 655816005284 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 655816005285 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 655816005286 RNase E interface [polypeptide binding]; other site 655816005287 trimer interface [polypeptide binding]; other site 655816005288 active site 655816005289 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 655816005290 putative nucleic acid binding region [nucleotide binding]; other site 655816005291 G-X-X-G motif; other site 655816005292 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 655816005293 RNA binding site [nucleotide binding]; other site 655816005294 domain interface; other site 655816005295 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 655816005296 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 655816005297 NodB motif; other site 655816005298 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 655816005299 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 655816005300 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 655816005301 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 655816005302 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 655816005303 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 655816005304 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 655816005305 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 655816005306 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 655816005307 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 655816005308 aspartate kinase I; Reviewed; Region: PRK08210 655816005309 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 655816005310 putative catalytic residues [active] 655816005311 putative nucleotide binding site [chemical binding]; other site 655816005312 putative aspartate binding site [chemical binding]; other site 655816005313 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 655816005314 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 655816005315 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 655816005316 dihydrodipicolinate synthase; Region: dapA; TIGR00674 655816005317 dimer interface [polypeptide binding]; other site 655816005318 active site 655816005319 catalytic residue [active] 655816005320 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 655816005321 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 655816005322 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 655816005323 Clp protease; Region: CLP_protease; pfam00574 655816005324 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 655816005325 active site 655816005326 YlzJ-like protein; Region: YlzJ; pfam14035 655816005327 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 655816005328 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 655816005329 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 655816005330 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 655816005331 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 655816005332 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816005333 DNA-binding site [nucleotide binding]; DNA binding site 655816005334 UTRA domain; Region: UTRA; pfam07702 655816005335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816005336 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816005337 putative substrate translocation pore; other site 655816005338 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 655816005339 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 655816005340 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 655816005341 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 655816005342 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 655816005343 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 655816005344 classical (c) SDRs; Region: SDR_c; cd05233 655816005345 NAD(P) binding site [chemical binding]; other site 655816005346 active site 655816005347 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 655816005348 ACT domain; Region: ACT; pfam01842 655816005349 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 655816005350 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 655816005351 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816005352 non-specific DNA binding site [nucleotide binding]; other site 655816005353 salt bridge; other site 655816005354 sequence-specific DNA binding site [nucleotide binding]; other site 655816005355 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 655816005356 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 655816005357 competence damage-inducible protein A; Provisional; Region: PRK00549 655816005358 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 655816005359 putative MPT binding site; other site 655816005360 competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199 655816005361 recombinase A; Provisional; Region: recA; PRK09354 655816005362 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 655816005363 hexamer interface [polypeptide binding]; other site 655816005364 Walker A motif; other site 655816005365 ATP binding site [chemical binding]; other site 655816005366 Walker B motif; other site 655816005367 Beta-lactamase; Region: Beta-lactamase; pfam00144 655816005368 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 655816005369 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 655816005370 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 655816005371 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816005372 Zn2+ binding site [ion binding]; other site 655816005373 Mg2+ binding site [ion binding]; other site 655816005374 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 655816005375 putative active site [active] 655816005376 metal binding site [ion binding]; metal-binding site 655816005377 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655816005378 homodimer binding site [polypeptide binding]; other site 655816005379 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 655816005380 Threonine dehydrogenase; Region: TDH; cd05281 655816005381 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 655816005382 structural Zn binding site [ion binding]; other site 655816005383 catalytic Zn binding site [ion binding]; other site 655816005384 tetramer interface [polypeptide binding]; other site 655816005385 NADP binding site [chemical binding]; other site 655816005386 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 655816005387 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 655816005388 substrate-cofactor binding pocket; other site 655816005389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816005390 catalytic residue [active] 655816005391 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 655816005392 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 655816005393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816005394 FeS/SAM binding site; other site 655816005395 TRAM domain; Region: TRAM; pfam01938 655816005396 Predicted membrane protein [Function unknown]; Region: COG4550 655816005397 Outer spore coat protein E (CotE); Region: CotE; pfam10628 655816005398 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 655816005399 MutS domain I; Region: MutS_I; pfam01624 655816005400 MutS domain II; Region: MutS_II; pfam05188 655816005401 MutS domain III; Region: MutS_III; pfam05192 655816005402 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 655816005403 Walker A/P-loop; other site 655816005404 ATP binding site [chemical binding]; other site 655816005405 Q-loop/lid; other site 655816005406 ABC transporter signature motif; other site 655816005407 Walker B; other site 655816005408 D-loop; other site 655816005409 H-loop/switch region; other site 655816005410 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 655816005411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816005412 ATP binding site [chemical binding]; other site 655816005413 Mg2+ binding site [ion binding]; other site 655816005414 G-X-G motif; other site 655816005415 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 655816005416 ATP binding site [chemical binding]; other site 655816005417 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 655816005418 CAAX protease self-immunity; Region: Abi; pfam02517 655816005419 Regulatory protein YrvL; Region: YrvL; pfam14184 655816005420 transcriptional regulator BetI; Validated; Region: PRK00767 655816005421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816005422 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 655816005423 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816005424 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 655816005425 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655816005426 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655816005427 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 655816005428 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 655816005429 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655816005430 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 655816005431 FMN binding site [chemical binding]; other site 655816005432 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 655816005433 substrate binding site [chemical binding]; other site 655816005434 putative catalytic residue [active] 655816005435 acyl carrier protein; Validated; Region: PRK07117 655816005436 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 655816005437 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 655816005438 dimer interface [polypeptide binding]; other site 655816005439 active site 655816005440 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 655816005441 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 655816005442 dimer interface [polypeptide binding]; other site 655816005443 active site 655816005444 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816005445 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 655816005446 substrate binding site [chemical binding]; other site 655816005447 oxyanion hole (OAH) forming residues; other site 655816005448 trimer interface [polypeptide binding]; other site 655816005449 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 655816005450 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816005451 substrate binding site [chemical binding]; other site 655816005452 oxyanion hole (OAH) forming residues; other site 655816005453 trimer interface [polypeptide binding]; other site 655816005454 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 655816005455 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 655816005456 acyl-activating enzyme (AAE) consensus motif; other site 655816005457 putative AMP binding site [chemical binding]; other site 655816005458 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005459 Condensation domain; Region: Condensation; pfam00668 655816005460 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005461 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005462 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 655816005463 acyl-activating enzyme (AAE) consensus motif; other site 655816005464 AMP binding site [chemical binding]; other site 655816005465 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005466 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005467 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005468 active site 655816005469 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005470 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005471 KR domain; Region: KR; pfam08659 655816005472 putative NADP binding site [chemical binding]; other site 655816005473 active site 655816005474 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005475 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 655816005476 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005477 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005478 active site 655816005479 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005480 putative NADP binding site [chemical binding]; other site 655816005481 active site 655816005482 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005483 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005484 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005485 active site 655816005486 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005487 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005488 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005489 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005490 active site 655816005491 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005492 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005493 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 655816005494 putative NADP binding site [chemical binding]; other site 655816005495 active site 655816005496 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 655816005497 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005498 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005499 active site 655816005500 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 655816005501 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 655816005502 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005503 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005504 active site 655816005505 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005506 putative NADP binding site [chemical binding]; other site 655816005507 active site 655816005508 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005509 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005510 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005511 active site 655816005512 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005513 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 655816005514 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005515 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005516 active site 655816005517 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005518 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005519 putative NADP binding site [chemical binding]; other site 655816005520 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 655816005521 active site 655816005522 Methyltransferase domain; Region: Methyltransf_12; pfam08242 655816005523 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 655816005524 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005525 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005526 active site 655816005527 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005528 putative NADP binding site [chemical binding]; other site 655816005529 active site 655816005530 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005531 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005532 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005533 active site 655816005534 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005535 Condensation domain; Region: Condensation; pfam00668 655816005536 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005537 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005538 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655816005539 acyl-activating enzyme (AAE) consensus motif; other site 655816005540 AMP binding site [chemical binding]; other site 655816005541 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005542 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005543 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005544 active site 655816005545 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005546 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005547 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 655816005548 putative NADP binding site [chemical binding]; other site 655816005549 active site 655816005550 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 655816005551 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005552 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005553 active site 655816005554 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005555 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005556 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 655816005557 putative NADP binding site [chemical binding]; other site 655816005558 active site 655816005559 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 655816005560 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005561 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005562 active site 655816005563 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005564 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005565 putative NADP binding site [chemical binding]; other site 655816005566 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 655816005567 active site 655816005568 Methyltransferase domain; Region: Methyltransf_23; pfam13489 655816005569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816005570 S-adenosylmethionine binding site [chemical binding]; other site 655816005571 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 655816005572 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005573 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005574 active site 655816005575 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005576 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005577 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005578 active site 655816005579 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005580 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 655816005581 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 655816005582 Cytochrome P450; Region: p450; cl12078 655816005583 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 655816005584 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 655816005585 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 655816005586 active site 655816005587 catalytic triad [active] 655816005588 WYL domain; Region: WYL; cl14852 655816005589 Phage-related replication protein [General function prediction only]; Region: COG4195 655816005590 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 655816005591 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 655816005592 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 655816005593 YmaF family; Region: YmaF; pfam12788 655816005594 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 655816005595 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 655816005596 bacterial Hfq-like; Region: Hfq; cd01716 655816005597 hexamer interface [polypeptide binding]; other site 655816005598 Sm1 motif; other site 655816005599 RNA binding site [nucleotide binding]; other site 655816005600 Sm2 motif; other site 655816005601 YmzC-like protein; Region: YmzC; pfam14157 655816005602 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 655816005603 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 655816005604 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 655816005605 Class I ribonucleotide reductase; Region: RNR_I; cd01679 655816005606 active site 655816005607 dimer interface [polypeptide binding]; other site 655816005608 catalytic residues [active] 655816005609 effector binding site; other site 655816005610 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 655816005611 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 655816005612 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 655816005613 dimer interface [polypeptide binding]; other site 655816005614 putative radical transfer pathway; other site 655816005615 diiron center [ion binding]; other site 655816005616 tyrosyl radical; other site 655816005617 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 655816005618 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 655816005619 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 655816005620 active site 655816005621 metal binding site [ion binding]; metal-binding site 655816005622 Sporulation related domain; Region: SPOR; pfam05036 655816005623 stage V sporulation protein K; Region: spore_V_K; TIGR02881 655816005624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816005625 Walker A motif; other site 655816005626 ATP binding site [chemical binding]; other site 655816005627 Walker B motif; other site 655816005628 arginine finger; other site 655816005629 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 655816005630 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 655816005631 HflX GTPase family; Region: HflX; cd01878 655816005632 G1 box; other site 655816005633 GTP/Mg2+ binding site [chemical binding]; other site 655816005634 Switch I region; other site 655816005635 G2 box; other site 655816005636 G3 box; other site 655816005637 Switch II region; other site 655816005638 G4 box; other site 655816005639 G5 box; other site 655816005640 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 655816005641 Aluminium resistance protein; Region: Alum_res; pfam06838 655816005642 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 655816005643 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 655816005644 DNA binding residues [nucleotide binding] 655816005645 putative dimer interface [polypeptide binding]; other site 655816005646 glutamine synthetase, type I; Region: GlnA; TIGR00653 655816005647 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 655816005648 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 655816005649 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 655816005650 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 655816005651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816005652 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 655816005653 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 655816005654 inhibitor binding site; inhibition site 655816005655 active site 655816005656 Transcriptional regulators [Transcription]; Region: MarR; COG1846 655816005657 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 655816005658 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 655816005659 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655816005660 nucleotide binding site [chemical binding]; other site 655816005661 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 655816005662 xylose isomerase; Provisional; Region: PRK05474 655816005663 xylose isomerase; Region: xylose_isom_A; TIGR02630 655816005664 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 655816005665 N- and C-terminal domain interface [polypeptide binding]; other site 655816005666 D-xylulose kinase; Region: XylB; TIGR01312 655816005667 active site 655816005668 MgATP binding site [chemical binding]; other site 655816005669 catalytic site [active] 655816005670 metal binding site [ion binding]; metal-binding site 655816005671 xylulose binding site [chemical binding]; other site 655816005672 homodimer interface [polypeptide binding]; other site 655816005673 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 655816005674 Staphylococcal nuclease homologues; Region: SNc; smart00318 655816005675 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 655816005676 Catalytic site; other site 655816005677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816005678 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 655816005679 putative substrate translocation pore; other site 655816005680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816005681 alanine racemase; Region: alr; TIGR00492 655816005682 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 655816005683 active site 655816005684 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655816005685 dimer interface [polypeptide binding]; other site 655816005686 substrate binding site [chemical binding]; other site 655816005687 catalytic residues [active] 655816005688 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 655816005689 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 655816005690 trimer interface [polypeptide binding]; other site 655816005691 active site 655816005692 thymidylate synthase; Reviewed; Region: thyA; PRK01827 655816005693 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 655816005694 dimerization interface [polypeptide binding]; other site 655816005695 active site 655816005696 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 655816005697 putative binding site; other site 655816005698 putative dimer interface [polypeptide binding]; other site 655816005699 YoqO-like protein; Region: YoqO; pfam14037 655816005700 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 655816005701 putative hydrophobic ligand binding site [chemical binding]; other site 655816005702 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 655816005703 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 655816005704 Chromate transporter; Region: Chromate_transp; pfam02417 655816005705 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 655816005706 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 655816005707 YndJ-like protein; Region: YndJ; pfam14158 655816005708 Protein of unknown function (DUF1180); Region: DUF1180; pfam06679 655816005709 Phage-related replication protein [General function prediction only]; Region: COG4195 655816005710 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 655816005711 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 655816005712 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 655816005713 putative active site [active] 655816005714 putative Mg binding site [ion binding]; other site 655816005715 LexA repressor; Validated; Region: PRK00215 655816005716 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816005717 putative DNA binding site [nucleotide binding]; other site 655816005718 putative Zn2+ binding site [ion binding]; other site 655816005719 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 655816005720 Catalytic site [active] 655816005721 cell division suppressor protein YneA; Provisional; Region: PRK14125 655816005722 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816005723 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 655816005724 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 655816005725 catalytic residues [active] 655816005726 catalytic nucleophile [active] 655816005727 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 655816005728 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 655816005729 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 655816005730 TPP-binding site [chemical binding]; other site 655816005731 dimer interface [polypeptide binding]; other site 655816005732 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 655816005733 PYR/PP interface [polypeptide binding]; other site 655816005734 dimer interface [polypeptide binding]; other site 655816005735 TPP binding site [chemical binding]; other site 655816005736 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655816005737 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 655816005738 hypothetical protein; Provisional; Region: PRK01844 655816005739 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 655816005740 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 655816005741 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 655816005742 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 655816005743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816005744 active site 655816005745 phosphorylation site [posttranslational modification] 655816005746 intermolecular recognition site; other site 655816005747 dimerization interface [polypeptide binding]; other site 655816005748 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 655816005749 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 655816005750 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 655816005751 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 655816005752 putative dimer interface [polypeptide binding]; other site 655816005753 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 655816005754 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 655816005755 aconitate hydratase; Validated; Region: PRK09277 655816005756 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 655816005757 substrate binding site [chemical binding]; other site 655816005758 ligand binding site [chemical binding]; other site 655816005759 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 655816005760 substrate binding site [chemical binding]; other site 655816005761 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 655816005762 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 655816005763 catalytic residues [active] 655816005764 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 655816005765 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 655816005766 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 655816005767 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 655816005768 active site 655816005769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 655816005770 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 655816005771 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 655816005772 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 655816005773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816005774 ATP binding site [chemical binding]; other site 655816005775 Mg2+ binding site [ion binding]; other site 655816005776 G-X-G motif; other site 655816005777 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 655816005778 anchoring element; other site 655816005779 dimer interface [polypeptide binding]; other site 655816005780 ATP binding site [chemical binding]; other site 655816005781 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 655816005782 active site 655816005783 putative metal-binding site [ion binding]; other site 655816005784 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 655816005785 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 655816005786 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 655816005787 CAP-like domain; other site 655816005788 active site 655816005789 primary dimer interface [polypeptide binding]; other site 655816005790 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816005791 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816005792 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816005793 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816005794 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 655816005795 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 655816005796 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 655816005797 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 655816005798 Cellulose binding domain; Region: CBM_3; pfam00942 655816005799 Predicted membrane protein [Function unknown]; Region: COG2246 655816005800 GtrA-like protein; Region: GtrA; pfam04138 655816005801 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 655816005802 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 655816005803 active site 655816005804 tetramer interface; other site 655816005805 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 655816005806 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 655816005807 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 655816005808 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 655816005809 classical (c) SDRs; Region: SDR_c; cd05233 655816005810 NAD(P) binding site [chemical binding]; other site 655816005811 active site 655816005812 YolD-like protein; Region: YolD; pfam08863 655816005813 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 655816005814 DHH family; Region: DHH; pfam01368 655816005815 DHHA1 domain; Region: DHHA1; pfam02272 655816005816 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 655816005817 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 655816005818 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 655816005819 enoyl-CoA hydratase; Provisional; Region: PRK07657 655816005820 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816005821 substrate binding site [chemical binding]; other site 655816005822 oxyanion hole (OAH) forming residues; other site 655816005823 trimer interface [polypeptide binding]; other site 655816005824 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 655816005825 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 655816005826 active site 655816005827 catalytic residues [active] 655816005828 metal binding site [ion binding]; metal-binding site 655816005829 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 655816005830 carboxyltransferase (CT) interaction site; other site 655816005831 biotinylation site [posttranslational modification]; other site 655816005832 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 655816005833 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816005834 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 655816005835 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 655816005836 AMP-binding domain protein; Validated; Region: PRK08315 655816005837 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 655816005838 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 655816005839 acyl-activating enzyme (AAE) consensus motif; other site 655816005840 putative AMP binding site [chemical binding]; other site 655816005841 putative active site [active] 655816005842 putative CoA binding site [chemical binding]; other site 655816005843 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 655816005844 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 655816005845 active site 655816005846 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816005847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 655816005848 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 655816005849 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 655816005850 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655816005851 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 655816005852 acyl-activating enzyme (AAE) consensus motif; other site 655816005853 AMP binding site [chemical binding]; other site 655816005854 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005855 Condensation domain; Region: Condensation; pfam00668 655816005856 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005857 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 655816005858 Condensation domain; Region: Condensation; pfam00668 655816005859 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005860 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655816005861 acyl-activating enzyme (AAE) consensus motif; other site 655816005862 AMP binding site [chemical binding]; other site 655816005863 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005864 Thioesterase domain; Region: Thioesterase; pfam00975 655816005865 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005866 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655816005867 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 655816005868 acyl-activating enzyme (AAE) consensus motif; other site 655816005869 AMP binding site [chemical binding]; other site 655816005870 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005871 Condensation domain; Region: Condensation; pfam00668 655816005872 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005873 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 655816005874 Condensation domain; Region: Condensation; pfam00668 655816005875 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005876 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655816005877 acyl-activating enzyme (AAE) consensus motif; other site 655816005878 AMP binding site [chemical binding]; other site 655816005879 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005880 Condensation domain; Region: Condensation; pfam00668 655816005881 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 655816005882 Condensation domain; Region: Condensation; pfam00668 655816005883 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005884 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655816005885 acyl-activating enzyme (AAE) consensus motif; other site 655816005886 AMP binding site [chemical binding]; other site 655816005887 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005888 Condensation domain; Region: Condensation; pfam00668 655816005889 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005890 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005891 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655816005892 acyl-activating enzyme (AAE) consensus motif; other site 655816005893 AMP binding site [chemical binding]; other site 655816005894 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005895 Condensation domain; Region: Condensation; pfam00668 655816005896 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005897 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005898 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 655816005899 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 655816005900 acyl-activating enzyme (AAE) consensus motif; other site 655816005901 putative AMP binding site [chemical binding]; other site 655816005902 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005903 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005904 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005905 active site 655816005906 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005907 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 655816005908 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816005909 inhibitor-cofactor binding pocket; inhibition site 655816005910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816005911 catalytic residue [active] 655816005912 Condensation domain; Region: Condensation; pfam00668 655816005913 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005914 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005915 Condensation domain; Region: Condensation; pfam00668 655816005916 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005917 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005918 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655816005919 acyl-activating enzyme (AAE) consensus motif; other site 655816005920 AMP binding site [chemical binding]; other site 655816005921 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816005922 Condensation domain; Region: Condensation; pfam00668 655816005923 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005924 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005925 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 655816005926 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655816005927 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 655816005928 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 655816005929 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 655816005930 active site 655816005931 catalytic residues [active] 655816005932 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 655816005933 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 655816005934 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 655816005935 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 655816005936 amidase catalytic site [active] 655816005937 Zn binding residues [ion binding]; other site 655816005938 substrate binding site [chemical binding]; other site 655816005939 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816005940 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 655816005941 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 655816005942 holin, SPP1 family; Region: holin_SPP1; TIGR01592 655816005943 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 655816005944 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 655816005945 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 655816005946 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 655816005947 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 655816005948 hypothetical protein; Region: PHA01818 655816005949 Phage tail protein; Region: Sipho_tail; pfam05709 655816005950 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 655816005951 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 655816005952 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 655816005953 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 655816005954 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 655816005955 oligomerization interface [polypeptide binding]; other site 655816005956 UDP-3-O-[3-hydroxymyristoyl]; Region: LpxD; COG1044 655816005957 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 655816005958 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Region: DM14; smart00685 655816005959 Phage capsid family; Region: Phage_capsid; pfam05065 655816005960 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 655816005961 Phage portal protein; Region: Phage_portal; pfam04860 655816005962 Phage-related protein [Function unknown]; Region: COG4695 655816005963 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 655816005964 Phage terminase, small subunit; Region: Terminase_4; cl01525 655816005965 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 655816005966 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 655816005967 active site 655816005968 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 655816005969 Int/Topo IB signature motif; other site 655816005970 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 655816005971 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 655816005972 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 655816005973 cofactor binding site; other site 655816005974 DNA binding site [nucleotide binding] 655816005975 substrate interaction site [chemical binding]; other site 655816005976 AAA domain; Region: AAA_17; cl17253 655816005977 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 655816005978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816005979 Walker A motif; other site 655816005980 ATP binding site [chemical binding]; other site 655816005981 Walker B motif; other site 655816005982 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 655816005983 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 655816005984 Domain of unknown function (DUF771); Region: DUF771; cl09962 655816005985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816005986 non-specific DNA binding site [nucleotide binding]; other site 655816005987 salt bridge; other site 655816005988 sequence-specific DNA binding site [nucleotide binding]; other site 655816005989 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 655816005990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816005991 sequence-specific DNA binding site [nucleotide binding]; other site 655816005992 salt bridge; other site 655816005993 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 655816005994 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 655816005995 Int/Topo IB signature motif; other site 655816005996 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 655816005997 Int/Topo IB signature motif; other site 655816005998 Helix-turn-helix domain; Region: HTH_17; cl17695 655816005999 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 655816006000 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 655816006001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816006002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816006003 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 655816006004 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 655816006005 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 655816006006 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 655816006007 active site 655816006008 dimer interface [polypeptide binding]; other site 655816006009 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 655816006010 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 655816006011 active site 655816006012 FMN binding site [chemical binding]; other site 655816006013 substrate binding site [chemical binding]; other site 655816006014 3Fe-4S cluster binding site [ion binding]; other site 655816006015 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 655816006016 domain interface; other site 655816006017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816006018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816006019 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 655816006020 putative dimerization interface [polypeptide binding]; other site 655816006021 gamma-glutamyl kinase; Provisional; Region: PRK13402 655816006022 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 655816006023 nucleotide binding site [chemical binding]; other site 655816006024 homotetrameric interface [polypeptide binding]; other site 655816006025 putative phosphate binding site [ion binding]; other site 655816006026 putative allosteric binding site; other site 655816006027 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 655816006028 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 655816006029 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 655816006030 Replication terminator protein; Region: RTP; pfam02334 655816006031 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 655816006032 Cytochrome P450; Region: p450; cl12078 655816006033 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 655816006034 classical (c) SDRs; Region: SDR_c; cd05233 655816006035 NAD(P) binding site [chemical binding]; other site 655816006036 active site 655816006037 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 655816006038 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 655816006039 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 655816006040 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 655816006041 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816006042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655816006043 Q-loop/lid; other site 655816006044 ABC transporter signature motif; other site 655816006045 Walker B; other site 655816006046 D-loop; other site 655816006047 H-loop/switch region; other site 655816006048 polyol permease family; Region: 2A0118; TIGR00897 655816006049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816006050 putative substrate translocation pore; other site 655816006051 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 655816006052 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 655816006053 putative N- and C-terminal domain interface [polypeptide binding]; other site 655816006054 putative active site [active] 655816006055 putative MgATP binding site [chemical binding]; other site 655816006056 catalytic site [active] 655816006057 metal binding site [ion binding]; metal-binding site 655816006058 carbohydrate binding site [chemical binding]; other site 655816006059 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 655816006060 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 655816006061 putative ligand binding site [chemical binding]; other site 655816006062 putative NAD binding site [chemical binding]; other site 655816006063 catalytic site [active] 655816006064 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 655816006065 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 655816006066 putative [4Fe-4S] binding site [ion binding]; other site 655816006067 putative molybdopterin cofactor binding site [chemical binding]; other site 655816006068 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 655816006069 putative molybdopterin cofactor binding site; other site 655816006070 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 655816006071 CHASE3 domain; Region: CHASE3; cl05000 655816006072 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 655816006073 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816006074 dimerization interface [polypeptide binding]; other site 655816006075 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816006076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816006077 dimer interface [polypeptide binding]; other site 655816006078 putative CheW interface [polypeptide binding]; other site 655816006079 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 655816006080 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 655816006081 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 655816006082 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 655816006083 Predicted membrane protein [Function unknown]; Region: COG3619 655816006084 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 655816006085 Amb_all domain; Region: Amb_all; smart00656 655816006086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006087 NAD(P) binding site [chemical binding]; other site 655816006088 active site 655816006089 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 655816006090 Uncharacterized conserved protein [Function unknown]; Region: COG2135 655816006091 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 655816006092 VanW like protein; Region: VanW; pfam04294 655816006093 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 655816006094 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816006095 salt bridge; other site 655816006096 non-specific DNA binding site [nucleotide binding]; other site 655816006097 sequence-specific DNA binding site [nucleotide binding]; other site 655816006098 Protein of unknown function (DUF817); Region: DUF817; pfam05675 655816006099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816006100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816006101 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655816006102 dimerization interface [polypeptide binding]; other site 655816006103 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 655816006104 EamA-like transporter family; Region: EamA; pfam00892 655816006105 EamA-like transporter family; Region: EamA; pfam00892 655816006106 CAAX protease self-immunity; Region: Abi; pfam02517 655816006107 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 655816006108 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 655816006109 conserved cys residue [active] 655816006110 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 655816006111 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 655816006112 Chitin binding domain; Region: Chitin_bind_3; pfam03067 655816006113 DinB family; Region: DinB; pfam05163 655816006114 DinB superfamily; Region: DinB_2; pfam12867 655816006115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816006116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816006117 Coenzyme A binding pocket [chemical binding]; other site 655816006118 DNA polymerase IV; Reviewed; Region: PRK03103 655816006119 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 655816006120 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 655816006121 Probable Catalytic site; other site 655816006122 metal-binding site 655816006123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 655816006124 Methyltransferase domain; Region: Methyltransf_23; pfam13489 655816006125 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 655816006126 putative metal binding site; other site 655816006127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816006128 binding surface 655816006129 TPR motif; other site 655816006130 TPR repeat; Region: TPR_11; pfam13414 655816006131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816006132 binding surface 655816006133 TPR motif; other site 655816006134 Methyltransferase domain; Region: Methyltransf_23; pfam13489 655816006135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816006136 S-adenosylmethionine binding site [chemical binding]; other site 655816006137 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 655816006138 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 655816006139 Domain of unknown function (DUF303); Region: DUF303; pfam03629 655816006140 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 655816006141 DNA binding site [nucleotide binding] 655816006142 active site 655816006143 Int/Topo IB signature motif; other site 655816006144 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 655816006145 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 655816006146 active site 655816006147 active site 655816006148 catalytic residues [active] 655816006149 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 655816006150 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 655816006151 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 655816006152 dimer interface [polypeptide binding]; other site 655816006153 putative tRNA-binding site [nucleotide binding]; other site 655816006154 Cupin domain; Region: Cupin_2; pfam07883 655816006155 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816006156 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816006157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816006158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816006159 Coenzyme A binding pocket [chemical binding]; other site 655816006160 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816006161 WHG domain; Region: WHG; pfam13305 655816006162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 655816006163 Predicted transcriptional regulator [Transcription]; Region: COG2378 655816006164 HTH domain; Region: HTH_11; pfam08279 655816006165 WYL domain; Region: WYL; pfam13280 655816006166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816006167 dimerization interface [polypeptide binding]; other site 655816006168 putative DNA binding site [nucleotide binding]; other site 655816006169 putative Zn2+ binding site [ion binding]; other site 655816006170 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 655816006171 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 655816006172 N-acetyl-D-glucosamine binding site [chemical binding]; other site 655816006173 catalytic residue [active] 655816006174 Predicted membrane protein [Function unknown]; Region: COG2322 655816006175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 655816006176 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 655816006177 putative dimer interface [polypeptide binding]; other site 655816006178 catalytic triad [active] 655816006179 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 655816006180 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 655816006181 putative di-iron ligands [ion binding]; other site 655816006182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816006183 Histidine kinase; Region: HisKA_3; pfam07730 655816006184 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 655816006185 ATP binding site [chemical binding]; other site 655816006186 Mg2+ binding site [ion binding]; other site 655816006187 G-X-G motif; other site 655816006188 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816006189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816006190 active site 655816006191 phosphorylation site [posttranslational modification] 655816006192 intermolecular recognition site; other site 655816006193 dimerization interface [polypeptide binding]; other site 655816006194 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816006195 DNA binding residues [nucleotide binding] 655816006196 dimerization interface [polypeptide binding]; other site 655816006197 putative transporter; Provisional; Region: PRK10484 655816006198 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 655816006199 Na binding site [ion binding]; other site 655816006200 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816006201 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816006202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 655816006203 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 655816006204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816006205 ATP binding site [chemical binding]; other site 655816006206 putative Mg++ binding site [ion binding]; other site 655816006207 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816006208 nucleotide binding region [chemical binding]; other site 655816006209 ATP-binding site [chemical binding]; other site 655816006210 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 655816006211 Helicase and RNase D C-terminal; Region: HRDC; smart00341 655816006212 azoreductase; Provisional; Region: PRK13556 655816006213 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 655816006214 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 655816006215 pentamer interface [polypeptide binding]; other site 655816006216 dodecaamer interface [polypeptide binding]; other site 655816006217 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 655816006218 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655816006219 NAD(P) binding site [chemical binding]; other site 655816006220 catalytic residues [active] 655816006221 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 655816006222 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 655816006223 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 655816006224 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 655816006225 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 655816006226 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 655816006227 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 655816006228 Na2 binding site [ion binding]; other site 655816006229 putative substrate binding site 1 [chemical binding]; other site 655816006230 Na binding site 1 [ion binding]; other site 655816006231 putative substrate binding site 2 [chemical binding]; other site 655816006232 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 655816006233 Sodium Bile acid symporter family; Region: SBF; pfam01758 655816006234 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 655816006235 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 655816006236 E3 interaction surface; other site 655816006237 lipoyl attachment site [posttranslational modification]; other site 655816006238 e3 binding domain; Region: E3_binding; pfam02817 655816006239 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 655816006240 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 655816006241 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 655816006242 TPP-binding site [chemical binding]; other site 655816006243 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 655816006244 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 655816006245 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 655816006246 metal ion-dependent adhesion site (MIDAS); other site 655816006247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816006248 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 655816006249 Walker A motif; other site 655816006250 ATP binding site [chemical binding]; other site 655816006251 Walker B motif; other site 655816006252 arginine finger; other site 655816006253 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 655816006254 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 655816006255 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 655816006256 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 655816006257 E-class dimer interface [polypeptide binding]; other site 655816006258 P-class dimer interface [polypeptide binding]; other site 655816006259 active site 655816006260 Cu2+ binding site [ion binding]; other site 655816006261 Zn2+ binding site [ion binding]; other site 655816006262 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816006263 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816006264 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816006265 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 655816006266 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816006267 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 655816006268 NlpC/P60 family; Region: NLPC_P60; pfam00877 655816006269 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 655816006270 glycosyltransferase, MGT family; Region: MGT; TIGR01426 655816006271 active site 655816006272 TDP-binding site; other site 655816006273 acceptor substrate-binding pocket; other site 655816006274 Uncharacterized conserved protein [Function unknown]; Region: COG1624 655816006275 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 655816006276 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 655816006277 multidrug efflux protein; Reviewed; Region: PRK01766 655816006278 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 655816006279 cation binding site [ion binding]; other site 655816006280 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816006281 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 655816006282 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 655816006283 rarD protein; Region: rarD; TIGR00688 655816006284 EamA-like transporter family; Region: EamA; pfam00892 655816006285 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 655816006286 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 655816006287 Predicted transcriptional regulators [Transcription]; Region: COG1733 655816006288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816006289 dimerization interface [polypeptide binding]; other site 655816006290 putative DNA binding site [nucleotide binding]; other site 655816006291 putative Zn2+ binding site [ion binding]; other site 655816006292 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 655816006293 dimer interface [polypeptide binding]; other site 655816006294 FMN binding site [chemical binding]; other site 655816006295 Predicted esterase [General function prediction only]; Region: COG0400 655816006296 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 655816006297 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 655816006298 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816006299 Zn binding site [ion binding]; other site 655816006300 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 655816006301 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816006302 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 655816006303 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 655816006304 Na binding site [ion binding]; other site 655816006305 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 655816006306 C-terminal peptidase (prc); Region: prc; TIGR00225 655816006307 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 655816006308 protein binding site [polypeptide binding]; other site 655816006309 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 655816006310 Catalytic dyad [active] 655816006311 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 655816006312 Methyltransferase domain; Region: Methyltransf_31; pfam13847 655816006313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816006314 S-adenosylmethionine binding site [chemical binding]; other site 655816006315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006316 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 655816006317 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 655816006318 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 655816006319 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 655816006320 YodL-like; Region: YodL; pfam14191 655816006321 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 655816006322 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 655816006323 active site 655816006324 YozD-like protein; Region: YozD; pfam14162 655816006325 hypothetical protein; Provisional; Region: PRK13672 655816006326 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 655816006327 Zn binding site [ion binding]; other site 655816006328 toxin interface [polypeptide binding]; other site 655816006329 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 655816006330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816006331 FeS/SAM binding site; other site 655816006332 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 655816006333 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 655816006334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816006335 Coenzyme A binding pocket [chemical binding]; other site 655816006336 acetylornithine deacetylase; Validated; Region: PRK06915 655816006337 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 655816006338 metal binding site [ion binding]; metal-binding site 655816006339 dimer interface [polypeptide binding]; other site 655816006340 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 655816006341 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 655816006342 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816006343 hypothetical protein; Provisional; Region: PRK06917 655816006344 inhibitor-cofactor binding pocket; inhibition site 655816006345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816006346 catalytic residue [active] 655816006347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816006348 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 655816006349 Coenzyme A binding pocket [chemical binding]; other site 655816006350 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 655816006351 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816006352 active site 655816006353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 655816006354 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 655816006355 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 655816006356 Phytase; Region: Phytase; cl17685 655816006357 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 655816006358 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 655816006359 NAD(P) binding site [chemical binding]; other site 655816006360 homodimer interface [polypeptide binding]; other site 655816006361 substrate binding site [chemical binding]; other site 655816006362 active site 655816006363 methionine sulfoxide reductase B; Provisional; Region: PRK00222 655816006364 SelR domain; Region: SelR; pfam01641 655816006365 methionine sulfoxide reductase A; Provisional; Region: PRK14054 655816006366 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816006367 MarR family; Region: MarR; pfam01047 655816006368 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 655816006369 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 655816006370 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 655816006371 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 655816006372 active site 655816006373 catalytic triad [active] 655816006374 oxyanion hole [active] 655816006375 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 655816006376 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 655816006377 Cu(I) binding site [ion binding]; other site 655816006378 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 655816006379 threonine dehydratase; Validated; Region: PRK08639 655816006380 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 655816006381 tetramer interface [polypeptide binding]; other site 655816006382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816006383 catalytic residue [active] 655816006384 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 655816006385 putative Ile/Val binding site [chemical binding]; other site 655816006386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816006387 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 655816006388 Walker A motif; other site 655816006389 ATP binding site [chemical binding]; other site 655816006390 Walker B motif; other site 655816006391 arginine finger; other site 655816006392 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 655816006393 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 655816006394 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 655816006395 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 655816006396 putative acyl-acceptor binding pocket; other site 655816006397 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 655816006398 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 655816006399 folate binding site [chemical binding]; other site 655816006400 NADP+ binding site [chemical binding]; other site 655816006401 thymidylate synthase; Reviewed; Region: thyA; PRK01827 655816006402 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 655816006403 dimerization interface [polypeptide binding]; other site 655816006404 active site 655816006405 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 655816006406 tetramer interfaces [polypeptide binding]; other site 655816006407 binuclear metal-binding site [ion binding]; other site 655816006408 YpjP-like protein; Region: YpjP; pfam14005 655816006409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816006410 S-adenosylmethionine binding site [chemical binding]; other site 655816006411 Disulphide isomerase; Region: Disulph_isomer; pfam06491 655816006412 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 655816006413 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 655816006414 Virulence factor; Region: Virulence_fact; pfam13769 655816006415 HEAT repeats; Region: HEAT_2; pfam13646 655816006416 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 655816006417 HEAT repeats; Region: HEAT_2; pfam13646 655816006418 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 655816006419 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 655816006420 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816006421 Zn2+ binding site [ion binding]; other site 655816006422 Mg2+ binding site [ion binding]; other site 655816006423 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 655816006424 catalytic residues [active] 655816006425 dimer interface [polypeptide binding]; other site 655816006426 homoserine O-succinyltransferase; Provisional; Region: PRK05368 655816006427 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 655816006428 proposed active site lysine [active] 655816006429 conserved cys residue [active] 655816006430 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 655816006431 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 655816006432 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 655816006433 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 655816006434 DNA-binding site [nucleotide binding]; DNA binding site 655816006435 RNA-binding motif; other site 655816006436 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 655816006437 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 655816006438 hypothetical protein; Validated; Region: PRK07708 655816006439 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 655816006440 RNA/DNA hybrid binding site [nucleotide binding]; other site 655816006441 active site 655816006442 conserved hypothetical integral membrane protein; Region: TIGR00697 655816006443 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 655816006444 RNA/DNA hybrid binding site [nucleotide binding]; other site 655816006445 active site 655816006446 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 655816006447 5'-3' exonuclease; Region: 53EXOc; smart00475 655816006448 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 655816006449 active site 655816006450 metal binding site 1 [ion binding]; metal-binding site 655816006451 putative 5' ssDNA interaction site; other site 655816006452 metal binding site 3; metal-binding site 655816006453 metal binding site 2 [ion binding]; metal-binding site 655816006454 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 655816006455 putative DNA binding site [nucleotide binding]; other site 655816006456 putative metal binding site [ion binding]; other site 655816006457 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 655816006458 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 655816006459 Dynamin family; Region: Dynamin_N; pfam00350 655816006460 G1 box; other site 655816006461 GTP/Mg2+ binding site [chemical binding]; other site 655816006462 G2 box; other site 655816006463 Switch I region; other site 655816006464 G3 box; other site 655816006465 Switch II region; other site 655816006466 G4 box; other site 655816006467 G5 box; other site 655816006468 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 655816006469 G1 box; other site 655816006470 GTP/Mg2+ binding site [chemical binding]; other site 655816006471 Dynamin family; Region: Dynamin_N; pfam00350 655816006472 G2 box; other site 655816006473 Switch I region; other site 655816006474 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 655816006475 G3 box; other site 655816006476 Switch II region; other site 655816006477 GTP/Mg2+ binding site [chemical binding]; other site 655816006478 G4 box; other site 655816006479 G5 box; other site 655816006480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 655816006481 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 655816006482 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 655816006483 malonyl-CoA binding site [chemical binding]; other site 655816006484 dimer interface [polypeptide binding]; other site 655816006485 active site 655816006486 product binding site; other site 655816006487 xanthine permease; Region: pbuX; TIGR03173 655816006488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816006489 active site 655816006490 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 655816006491 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 655816006492 active site 655816006493 Zn binding site [ion binding]; other site 655816006494 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 655816006495 Entner-Doudoroff aldolase; Region: eda; TIGR01182 655816006496 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 655816006497 active site 655816006498 intersubunit interface [polypeptide binding]; other site 655816006499 catalytic residue [active] 655816006500 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655816006501 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 655816006502 substrate binding site [chemical binding]; other site 655816006503 ATP binding site [chemical binding]; other site 655816006504 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816006505 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816006506 DNA binding site [nucleotide binding] 655816006507 domain linker motif; other site 655816006508 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 655816006509 putative dimerization interface [polypeptide binding]; other site 655816006510 putative ligand binding site [chemical binding]; other site 655816006511 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 655816006512 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 655816006513 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 655816006514 NADP binding site [chemical binding]; other site 655816006515 homodimer interface [polypeptide binding]; other site 655816006516 active site 655816006517 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 655816006518 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 655816006519 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 655816006520 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 655816006521 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 655816006522 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 655816006523 cell division protein GpsB; Provisional; Region: PRK14127 655816006524 DivIVA domain; Region: DivI1A_domain; TIGR03544 655816006525 hypothetical protein; Provisional; Region: PRK13660 655816006526 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 655816006527 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 655816006528 RNase_H superfamily; Region: RNase_H_2; pfam13482 655816006529 active site 655816006530 substrate binding site [chemical binding]; other site 655816006531 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 655816006532 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816006533 ATP binding site [chemical binding]; other site 655816006534 putative Mg++ binding site [ion binding]; other site 655816006535 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816006536 nucleotide binding region [chemical binding]; other site 655816006537 ATP-binding site [chemical binding]; other site 655816006538 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 655816006539 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 655816006540 HPr interaction site; other site 655816006541 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655816006542 active site 655816006543 phosphorylation site [posttranslational modification] 655816006544 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 655816006545 YppG-like protein; Region: YppG; pfam14179 655816006546 YppF-like protein; Region: YppF; pfam14178 655816006547 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 655816006548 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 655816006549 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 655816006550 Transglycosylase; Region: Transgly; pfam00912 655816006551 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 655816006552 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 655816006553 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 655816006554 Interdomain contacts; other site 655816006555 Cytokine receptor motif; other site 655816006556 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 655816006557 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 655816006558 minor groove reading motif; other site 655816006559 helix-hairpin-helix signature motif; other site 655816006560 substrate binding pocket [chemical binding]; other site 655816006561 active site 655816006562 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 655816006563 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 655816006564 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 655816006565 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 655816006566 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 655816006567 putative dimer interface [polypeptide binding]; other site 655816006568 putative anticodon binding site; other site 655816006569 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 655816006570 homodimer interface [polypeptide binding]; other site 655816006571 motif 1; other site 655816006572 motif 2; other site 655816006573 active site 655816006574 motif 3; other site 655816006575 aspartate aminotransferase; Provisional; Region: PRK05764 655816006576 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816006577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816006578 homodimer interface [polypeptide binding]; other site 655816006579 catalytic residue [active] 655816006580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 655816006581 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 655816006582 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 655816006583 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 655816006584 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 655816006585 active site 655816006586 catalytic site [active] 655816006587 substrate binding site [chemical binding]; other site 655816006588 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 655816006589 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 655816006590 tetramerization interface [polypeptide binding]; other site 655816006591 active site 655816006592 pantoate--beta-alanine ligase; Region: panC; TIGR00018 655816006593 Pantoate-beta-alanine ligase; Region: PanC; cd00560 655816006594 active site 655816006595 ATP-binding site [chemical binding]; other site 655816006596 pantoate-binding site; other site 655816006597 HXXH motif; other site 655816006598 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 655816006599 oligomerization interface [polypeptide binding]; other site 655816006600 active site 655816006601 metal binding site [ion binding]; metal-binding site 655816006602 Biotin operon repressor [Transcription]; Region: BirA; COG1654 655816006603 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 655816006604 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 655816006605 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 655816006606 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 655816006607 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 655816006608 active site 655816006609 NTP binding site [chemical binding]; other site 655816006610 metal binding triad [ion binding]; metal-binding site 655816006611 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 655816006612 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 655816006613 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 655816006614 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 655816006615 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 655816006616 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 655816006617 active site 655816006618 dimer interfaces [polypeptide binding]; other site 655816006619 catalytic residues [active] 655816006620 dihydrodipicolinate reductase; Region: dapB; TIGR00036 655816006621 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 655816006622 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 655816006623 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 655816006624 homodimer interface [polypeptide binding]; other site 655816006625 metal binding site [ion binding]; metal-binding site 655816006626 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816006627 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816006628 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816006629 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 655816006630 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 655816006631 Predicted membrane protein [Function unknown]; Region: COG4347 655816006632 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 655816006633 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 655816006634 intrachain domain interface; other site 655816006635 Qi binding site; other site 655816006636 Qo binding site; other site 655816006637 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 655816006638 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 655816006639 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 655816006640 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 655816006641 interchain domain interface [polypeptide binding]; other site 655816006642 intrachain domain interface; other site 655816006643 heme bH binding site [chemical binding]; other site 655816006644 Qi binding site; other site 655816006645 heme bL binding site [chemical binding]; other site 655816006646 Qo binding site; other site 655816006647 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 655816006648 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 655816006649 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 655816006650 iron-sulfur cluster [ion binding]; other site 655816006651 [2Fe-2S] cluster binding site [ion binding]; other site 655816006652 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 655816006653 hypothetical protein; Provisional; Region: PRK03636 655816006654 UPF0302 domain; Region: UPF0302; pfam08864 655816006655 IDEAL domain; Region: IDEAL; pfam08858 655816006656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 655816006657 TPR motif; other site 655816006658 binding surface 655816006659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816006660 binding surface 655816006661 TPR motif; other site 655816006662 Tetratricopeptide repeat; Region: TPR_16; pfam13432 655816006663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816006664 TPR motif; other site 655816006665 binding surface 655816006666 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 655816006667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816006668 binding surface 655816006669 TPR motif; other site 655816006670 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 655816006671 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 655816006672 hinge; other site 655816006673 active site 655816006674 prephenate dehydrogenase; Validated; Region: PRK06545 655816006675 prephenate dehydrogenase; Validated; Region: PRK08507 655816006676 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 655816006677 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 655816006678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816006679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816006680 homodimer interface [polypeptide binding]; other site 655816006681 catalytic residue [active] 655816006682 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 655816006683 substrate binding site [chemical binding]; other site 655816006684 active site 655816006685 catalytic residues [active] 655816006686 heterodimer interface [polypeptide binding]; other site 655816006687 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 655816006688 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 655816006689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816006690 catalytic residue [active] 655816006691 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 655816006692 active site 655816006693 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 655816006694 active site 655816006695 ribulose/triose binding site [chemical binding]; other site 655816006696 phosphate binding site [ion binding]; other site 655816006697 substrate (anthranilate) binding pocket [chemical binding]; other site 655816006698 product (indole) binding pocket [chemical binding]; other site 655816006699 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 655816006700 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 655816006701 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 655816006702 anthranilate synthase component I; Provisional; Region: PRK13569 655816006703 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 655816006704 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 655816006705 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 655816006706 homotrimer interaction site [polypeptide binding]; other site 655816006707 active site 655816006708 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 655816006709 active site 655816006710 dimer interface [polypeptide binding]; other site 655816006711 metal binding site [ion binding]; metal-binding site 655816006712 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 655816006713 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 655816006714 Tetramer interface [polypeptide binding]; other site 655816006715 active site 655816006716 FMN-binding site [chemical binding]; other site 655816006717 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 655816006718 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 655816006719 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 655816006720 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 655816006721 active site 655816006722 multimer interface [polypeptide binding]; other site 655816006723 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 655816006724 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 655816006725 substrate binding pocket [chemical binding]; other site 655816006726 chain length determination region; other site 655816006727 substrate-Mg2+ binding site; other site 655816006728 catalytic residues [active] 655816006729 aspartate-rich region 1; other site 655816006730 active site lid residues [active] 655816006731 aspartate-rich region 2; other site 655816006732 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 655816006733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816006734 S-adenosylmethionine binding site [chemical binding]; other site 655816006735 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 655816006736 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 655816006737 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 655816006738 homodecamer interface [polypeptide binding]; other site 655816006739 GTP cyclohydrolase I; Provisional; Region: PLN03044 655816006740 active site 655816006741 putative catalytic site residues [active] 655816006742 zinc binding site [ion binding]; other site 655816006743 GTP-CH-I/GFRP interaction surface; other site 655816006744 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 655816006745 IHF dimer interface [polypeptide binding]; other site 655816006746 IHF - DNA interface [nucleotide binding]; other site 655816006747 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 655816006748 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 655816006749 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 655816006750 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 655816006751 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 655816006752 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 655816006753 GTP-binding protein Der; Reviewed; Region: PRK00093 655816006754 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 655816006755 G1 box; other site 655816006756 GTP/Mg2+ binding site [chemical binding]; other site 655816006757 Switch I region; other site 655816006758 G2 box; other site 655816006759 Switch II region; other site 655816006760 G3 box; other site 655816006761 G4 box; other site 655816006762 G5 box; other site 655816006763 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 655816006764 G1 box; other site 655816006765 GTP/Mg2+ binding site [chemical binding]; other site 655816006766 Switch I region; other site 655816006767 G2 box; other site 655816006768 G3 box; other site 655816006769 Switch II region; other site 655816006770 G4 box; other site 655816006771 G5 box; other site 655816006772 YIEGIA protein; Region: YIEGIA; pfam14045 655816006773 YpzI-like protein; Region: YpzI; pfam14140 655816006774 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 655816006775 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 655816006776 homotetramer interface [polypeptide binding]; other site 655816006777 FMN binding site [chemical binding]; other site 655816006778 homodimer contacts [polypeptide binding]; other site 655816006779 putative active site [active] 655816006780 putative substrate binding site [chemical binding]; other site 655816006781 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 655816006782 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 655816006783 RNA binding site [nucleotide binding]; other site 655816006784 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 655816006785 RNA binding site [nucleotide binding]; other site 655816006786 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 655816006787 RNA binding site [nucleotide binding]; other site 655816006788 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 655816006789 RNA binding site [nucleotide binding]; other site 655816006790 cytidylate kinase; Provisional; Region: cmk; PRK00023 655816006791 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 655816006792 CMP-binding site; other site 655816006793 The sites determining sugar specificity; other site 655816006794 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 655816006795 Flagellar protein YcgR; Region: YcgR_2; pfam12945 655816006796 PilZ domain; Region: PilZ; pfam07238 655816006797 germination protein YpeB; Region: spore_YpeB; TIGR02889 655816006798 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 655816006799 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 655816006800 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 655816006801 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 655816006802 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 655816006803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 655816006804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816006805 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 655816006806 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 655816006807 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 655816006808 NAD(P) binding site [chemical binding]; other site 655816006809 adaptor protein; Provisional; Region: PRK02899 655816006810 phosphodiesterase YaeI; Provisional; Region: PRK11340 655816006811 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 655816006812 putative active site [active] 655816006813 putative metal binding site [ion binding]; other site 655816006814 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 655816006815 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816006816 CAAX protease self-immunity; Region: Abi; pfam02517 655816006817 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 655816006818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816006819 ATP binding site [chemical binding]; other site 655816006820 putative Mg++ binding site [ion binding]; other site 655816006821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816006822 nucleotide binding region [chemical binding]; other site 655816006823 ATP-binding site [chemical binding]; other site 655816006824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 655816006825 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 655816006826 Predicted membrane protein [Function unknown]; Region: COG3601 655816006827 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 655816006828 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 655816006829 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 655816006830 ligand binding site [chemical binding]; other site 655816006831 NAD binding site [chemical binding]; other site 655816006832 dimerization interface [polypeptide binding]; other site 655816006833 catalytic site [active] 655816006834 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 655816006835 putative L-serine binding site [chemical binding]; other site 655816006836 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 655816006837 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 655816006838 active site 655816006839 catalytic residue [active] 655816006840 dimer interface [polypeptide binding]; other site 655816006841 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 655816006842 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816006843 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816006844 DNA binding residues [nucleotide binding] 655816006845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 655816006846 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816006847 dimerization interface [polypeptide binding]; other site 655816006848 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816006849 putative active site [active] 655816006850 heme pocket [chemical binding]; other site 655816006851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816006852 dimer interface [polypeptide binding]; other site 655816006853 phosphorylation site [posttranslational modification] 655816006854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816006855 ATP binding site [chemical binding]; other site 655816006856 Mg2+ binding site [ion binding]; other site 655816006857 G-X-G motif; other site 655816006858 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816006859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816006860 active site 655816006861 phosphorylation site [posttranslational modification] 655816006862 intermolecular recognition site; other site 655816006863 dimerization interface [polypeptide binding]; other site 655816006864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816006865 DNA binding site [nucleotide binding] 655816006866 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 655816006867 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 655816006868 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 655816006869 ResB-like family; Region: ResB; pfam05140 655816006870 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 655816006871 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 655816006872 catalytic residues [active] 655816006873 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 655816006874 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816006875 RNA binding surface [nucleotide binding]; other site 655816006876 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 655816006877 active site 655816006878 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 655816006879 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 655816006880 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 655816006881 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 655816006882 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 655816006883 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 655816006884 segregation and condensation protein B; Region: TIGR00281 655816006885 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 655816006886 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 655816006887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816006888 Coenzyme A binding pocket [chemical binding]; other site 655816006889 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 655816006890 homopentamer interface [polypeptide binding]; other site 655816006891 active site 655816006892 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 655816006893 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 655816006894 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 655816006895 dimerization interface [polypeptide binding]; other site 655816006896 active site 655816006897 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 655816006898 Lumazine binding domain; Region: Lum_binding; pfam00677 655816006899 Lumazine binding domain; Region: Lum_binding; pfam00677 655816006900 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 655816006901 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 655816006902 catalytic motif [active] 655816006903 Zn binding site [ion binding]; other site 655816006904 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 655816006905 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 655816006906 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 655816006907 Catalytic site [active] 655816006908 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 655816006909 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 655816006910 active site 655816006911 Predicted secreted protein [Function unknown]; Region: COG4086 655816006912 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 655816006913 diaminopimelate decarboxylase; Region: lysA; TIGR01048 655816006914 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 655816006915 active site 655816006916 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655816006917 substrate binding site [chemical binding]; other site 655816006918 catalytic residues [active] 655816006919 dimer interface [polypeptide binding]; other site 655816006920 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 655816006921 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 655816006922 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 655816006923 stage V sporulation protein AD; Validated; Region: PRK08304 655816006924 stage V sporulation protein AD; Provisional; Region: PRK12404 655816006925 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 655816006926 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 655816006927 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 655816006928 sporulation sigma factor SigF; Validated; Region: PRK05572 655816006929 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816006930 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 655816006931 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816006932 DNA binding residues [nucleotide binding] 655816006933 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 655816006934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816006935 ATP binding site [chemical binding]; other site 655816006936 Mg2+ binding site [ion binding]; other site 655816006937 G-X-G motif; other site 655816006938 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 655816006939 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 655816006940 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 655816006941 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 655816006942 purine nucleoside phosphorylase; Provisional; Region: PRK08202 655816006943 phosphopentomutase; Provisional; Region: PRK05362 655816006944 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 655816006945 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 655816006946 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 655816006947 active site 655816006948 Int/Topo IB signature motif; other site 655816006949 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 655816006950 ferric uptake regulator; Provisional; Region: fur; PRK09462 655816006951 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 655816006952 metal binding site 2 [ion binding]; metal-binding site 655816006953 putative DNA binding helix; other site 655816006954 metal binding site 1 [ion binding]; metal-binding site 655816006955 dimer interface [polypeptide binding]; other site 655816006956 structural Zn2+ binding site [ion binding]; other site 655816006957 stage II sporulation protein M; Region: spo_II_M; TIGR02831 655816006958 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 655816006959 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 655816006960 Malic enzyme, N-terminal domain; Region: malic; pfam00390 655816006961 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 655816006962 NAD(P) binding pocket [chemical binding]; other site 655816006963 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 655816006964 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 655816006965 Aspartase; Region: Aspartase; cd01357 655816006966 active sites [active] 655816006967 tetramer interface [polypeptide binding]; other site 655816006968 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 655816006969 active site 655816006970 homodimer interface [polypeptide binding]; other site 655816006971 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 655816006972 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816006973 non-specific DNA binding site [nucleotide binding]; other site 655816006974 salt bridge; other site 655816006975 sequence-specific DNA binding site [nucleotide binding]; other site 655816006976 TIGR00375 family protein; Region: TIGR00375 655816006977 Homeodomain-like domain; Region: HTH_23; pfam13384 655816006978 putative transposase OrfB; Reviewed; Region: PHA02517 655816006979 HTH-like domain; Region: HTH_21; pfam13276 655816006980 Integrase core domain; Region: rve; pfam00665 655816006981 Integrase core domain; Region: rve_3; pfam13683 655816006982 TIGR00375 family protein; Region: TIGR00375 655816006983 PHP-associated; Region: PHP_C; pfam13263 655816006984 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 655816006985 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 655816006986 dimer interface [polypeptide binding]; other site 655816006987 ADP-ribose binding site [chemical binding]; other site 655816006988 active site 655816006989 nudix motif; other site 655816006990 metal binding site [ion binding]; metal-binding site 655816006991 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 655816006992 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816006993 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655816006994 active site 655816006995 catalytic tetrad [active] 655816006996 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 655816006997 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 655816006998 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 655816006999 cell division protein FtsW; Region: ftsW; TIGR02614 655816007000 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 655816007001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816007002 sequence-specific DNA binding site [nucleotide binding]; other site 655816007003 salt bridge; other site 655816007004 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 655816007005 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 655816007006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 655816007007 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 655816007008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816007009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 655816007010 Coenzyme A binding pocket [chemical binding]; other site 655816007011 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 655816007012 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 655816007013 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 655816007014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816007015 Coenzyme A binding pocket [chemical binding]; other site 655816007016 YolD-like protein; Region: YolD; pfam08863 655816007017 DNA polymerase IV; Reviewed; Region: PRK03103 655816007018 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 655816007019 active site 655816007020 DNA binding site [nucleotide binding] 655816007021 YqzH-like protein; Region: YqzH; pfam14164 655816007022 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816007023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816007024 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816007025 putative substrate translocation pore; other site 655816007026 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 655816007027 putative dimer interface [polypeptide binding]; other site 655816007028 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816007029 ligand binding site [chemical binding]; other site 655816007030 Zn binding site [ion binding]; other site 655816007031 pantothenate kinase; Provisional; Region: PRK05439 655816007032 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 655816007033 ATP-binding site [chemical binding]; other site 655816007034 CoA-binding site [chemical binding]; other site 655816007035 Mg2+-binding site [ion binding]; other site 655816007036 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 655816007037 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 655816007038 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816007039 catalytic residue [active] 655816007040 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 655816007041 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 655816007042 NADP binding site [chemical binding]; other site 655816007043 homodimer interface [polypeptide binding]; other site 655816007044 substrate binding site [chemical binding]; other site 655816007045 active site 655816007046 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 655816007047 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 655816007048 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 655816007049 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 655816007050 putative metal binding site [ion binding]; other site 655816007051 putative dimer interface [polypeptide binding]; other site 655816007052 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 655816007053 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 655816007054 active site 655816007055 FMN binding site [chemical binding]; other site 655816007056 substrate binding site [chemical binding]; other site 655816007057 homotetramer interface [polypeptide binding]; other site 655816007058 catalytic residue [active] 655816007059 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816007060 Transposase; Region: HTH_Tnp_1; pfam01527 655816007061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655816007062 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 655816007063 putative hydrolase; Provisional; Region: PRK02113 655816007064 ribonuclease Z; Region: RNase_Z; TIGR02651 655816007065 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 655816007066 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 655816007067 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 655816007068 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 655816007069 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 655816007070 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 655816007071 DNA polymerase IV; Validated; Region: PRK01810 655816007072 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 655816007073 active site 655816007074 DNA binding site [nucleotide binding] 655816007075 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 655816007076 OxaA-like protein precursor; Validated; Region: PRK01622 655816007077 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 655816007078 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 655816007079 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 655816007080 peptidase T-like protein; Region: PepT-like; TIGR01883 655816007081 metal binding site [ion binding]; metal-binding site 655816007082 putative dimer interface [polypeptide binding]; other site 655816007083 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 655816007084 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 655816007085 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 655816007086 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816007087 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 655816007088 dimer interface [polypeptide binding]; other site 655816007089 substrate binding site [chemical binding]; other site 655816007090 metal binding site [ion binding]; metal-binding site 655816007091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 655816007092 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 655816007093 Predicted membrane protein [Function unknown]; Region: COG4129 655816007094 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 655816007095 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 655816007096 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 655816007097 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 655816007098 Walker A/P-loop; other site 655816007099 ATP binding site [chemical binding]; other site 655816007100 Q-loop/lid; other site 655816007101 ABC transporter signature motif; other site 655816007102 Walker B; other site 655816007103 D-loop; other site 655816007104 H-loop/switch region; other site 655816007105 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 655816007106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816007107 dimer interface [polypeptide binding]; other site 655816007108 conserved gate region; other site 655816007109 putative PBP binding loops; other site 655816007110 ABC-ATPase subunit interface; other site 655816007111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655816007112 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 655816007113 substrate binding pocket [chemical binding]; other site 655816007114 membrane-bound complex binding site; other site 655816007115 hinge residues; other site 655816007116 Disulphide isomerase; Region: Disulph_isomer; pfam06491 655816007117 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 655816007118 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 655816007119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816007120 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816007121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816007122 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 655816007123 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 655816007124 DNA binding residues [nucleotide binding] 655816007125 drug binding residues [chemical binding]; other site 655816007126 dimer interface [polypeptide binding]; other site 655816007127 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 655816007128 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 655816007129 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 655816007130 E3 interaction surface; other site 655816007131 lipoyl attachment site [posttranslational modification]; other site 655816007132 e3 binding domain; Region: E3_binding; pfam02817 655816007133 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 655816007134 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 655816007135 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 655816007136 alpha subunit interface [polypeptide binding]; other site 655816007137 TPP binding site [chemical binding]; other site 655816007138 heterodimer interface [polypeptide binding]; other site 655816007139 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655816007140 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 655816007141 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 655816007142 tetramer interface [polypeptide binding]; other site 655816007143 TPP-binding site [chemical binding]; other site 655816007144 heterodimer interface [polypeptide binding]; other site 655816007145 phosphorylation loop region [posttranslational modification] 655816007146 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 655816007147 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 655816007148 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816007149 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 655816007150 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655816007151 nucleotide binding site [chemical binding]; other site 655816007152 Acetokinase family; Region: Acetate_kinase; cl17229 655816007153 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 655816007154 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 655816007155 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 655816007156 NAD binding site [chemical binding]; other site 655816007157 Phe binding site; other site 655816007158 phosphate butyryltransferase; Validated; Region: PRK07742 655816007159 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 655816007160 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816007161 putative active site [active] 655816007162 heme pocket [chemical binding]; other site 655816007163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816007164 putative active site [active] 655816007165 heme pocket [chemical binding]; other site 655816007166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816007167 Walker A motif; other site 655816007168 ATP binding site [chemical binding]; other site 655816007169 Walker B motif; other site 655816007170 arginine finger; other site 655816007171 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 655816007172 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 655816007173 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 655816007174 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 655816007175 tetramer interface [polypeptide binding]; other site 655816007176 active site 655816007177 Mg2+/Mn2+ binding site [ion binding]; other site 655816007178 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 655816007179 2-methylcitrate dehydratase; Region: prpD; TIGR02330 655816007180 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 655816007181 dimer interface [polypeptide binding]; other site 655816007182 Citrate synthase; Region: Citrate_synt; pfam00285 655816007183 active site 655816007184 coenzyme A binding site [chemical binding]; other site 655816007185 citrylCoA binding site [chemical binding]; other site 655816007186 oxalacetate/citrate binding site [chemical binding]; other site 655816007187 catalytic triad [active] 655816007188 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 655816007189 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 655816007190 FAD binding site [chemical binding]; other site 655816007191 homotetramer interface [polypeptide binding]; other site 655816007192 substrate binding pocket [chemical binding]; other site 655816007193 catalytic base [active] 655816007194 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 655816007195 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 655816007196 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 655816007197 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 655816007198 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 655816007199 dimer interface [polypeptide binding]; other site 655816007200 active site 655816007201 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 655816007202 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 655816007203 active site 655816007204 catalytic site [active] 655816007205 metal binding site [ion binding]; metal-binding site 655816007206 dimer interface [polypeptide binding]; other site 655816007207 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 655816007208 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 655816007209 active site 655816007210 metal binding site [ion binding]; metal-binding site 655816007211 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 655816007212 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 655816007213 putative active site [active] 655816007214 putative FMN binding site [chemical binding]; other site 655816007215 putative substrate binding site [chemical binding]; other site 655816007216 putative catalytic residue [active] 655816007217 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 655816007218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816007219 active site 655816007220 phosphorylation site [posttranslational modification] 655816007221 intermolecular recognition site; other site 655816007222 dimerization interface [polypeptide binding]; other site 655816007223 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 655816007224 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 655816007225 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 655816007226 protein binding site [polypeptide binding]; other site 655816007227 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 655816007228 DNA repair protein RecN; Region: recN; TIGR00634 655816007229 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 655816007230 Walker A/P-loop; other site 655816007231 ATP binding site [chemical binding]; other site 655816007232 Q-loop/lid; other site 655816007233 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 655816007234 ABC transporter signature motif; other site 655816007235 Walker B; other site 655816007236 D-loop; other site 655816007237 H-loop/switch region; other site 655816007238 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 655816007239 arginine repressor; Provisional; Region: PRK04280 655816007240 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 655816007241 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 655816007242 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816007243 RNA binding surface [nucleotide binding]; other site 655816007244 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 655816007245 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 655816007246 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 655816007247 TPP-binding site; other site 655816007248 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 655816007249 PYR/PP interface [polypeptide binding]; other site 655816007250 dimer interface [polypeptide binding]; other site 655816007251 TPP binding site [chemical binding]; other site 655816007252 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655816007253 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 655816007254 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 655816007255 substrate binding pocket [chemical binding]; other site 655816007256 chain length determination region; other site 655816007257 substrate-Mg2+ binding site; other site 655816007258 catalytic residues [active] 655816007259 aspartate-rich region 1; other site 655816007260 active site lid residues [active] 655816007261 aspartate-rich region 2; other site 655816007262 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 655816007263 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 655816007264 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 655816007265 generic binding surface II; other site 655816007266 generic binding surface I; other site 655816007267 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 655816007268 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 655816007269 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 655816007270 homodimer interface [polypeptide binding]; other site 655816007271 NADP binding site [chemical binding]; other site 655816007272 substrate binding site [chemical binding]; other site 655816007273 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 655816007274 putative RNA binding site [nucleotide binding]; other site 655816007275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 655816007276 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 655816007277 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816007278 ATP-grasp domain; Region: ATP-grasp_4; cl17255 655816007279 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 655816007280 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 655816007281 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 655816007282 carboxyltransferase (CT) interaction site; other site 655816007283 biotinylation site [posttranslational modification]; other site 655816007284 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 655816007285 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 655816007286 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 655816007287 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 655816007288 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 655816007289 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 655816007290 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 655816007291 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 655816007292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816007293 Walker A motif; other site 655816007294 ATP binding site [chemical binding]; other site 655816007295 Walker B motif; other site 655816007296 arginine finger; other site 655816007297 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 655816007298 elongation factor P; Validated; Region: PRK00529 655816007299 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 655816007300 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 655816007301 RNA binding site [nucleotide binding]; other site 655816007302 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 655816007303 RNA binding site [nucleotide binding]; other site 655816007304 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 655816007305 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 655816007306 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 655816007307 active site 655816007308 Dehydroquinase class II; Region: DHquinase_II; pfam01220 655816007309 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 655816007310 trimer interface [polypeptide binding]; other site 655816007311 active site 655816007312 dimer interface [polypeptide binding]; other site 655816007313 Conserved membrane protein YqhR; Region: YqhR; pfam11085 655816007314 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 655816007315 kinase; Region: PLN02967 655816007316 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 655816007317 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 655816007318 active site 655816007319 nucleophile elbow; other site 655816007320 manganese transport transcriptional regulator; Provisional; Region: PRK03902 655816007321 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 655816007322 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 655816007323 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 655816007324 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 655816007325 active site residue [active] 655816007326 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 655816007327 tetramer interface [polypeptide binding]; other site 655816007328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816007329 catalytic residue [active] 655816007330 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 655816007331 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 655816007332 tetramer interface [polypeptide binding]; other site 655816007333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816007334 catalytic residue [active] 655816007335 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 655816007336 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 655816007337 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 655816007338 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 655816007339 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816007340 ATP binding site [chemical binding]; other site 655816007341 putative Mg++ binding site [ion binding]; other site 655816007342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816007343 nucleotide binding region [chemical binding]; other site 655816007344 ATP-binding site [chemical binding]; other site 655816007345 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 655816007346 Anti-repressor SinI; Region: SinI; pfam08671 655816007347 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 655816007348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816007349 non-specific DNA binding site [nucleotide binding]; other site 655816007350 salt bridge; other site 655816007351 sequence-specific DNA binding site [nucleotide binding]; other site 655816007352 Anti-repressor SinI; Region: SinI; pfam08671 655816007353 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 655816007354 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 655816007355 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 655816007356 Catalytic site [active] 655816007357 YqxM protein; Region: YqxM_for_SipW; TIGR04087 655816007358 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 655816007359 YqzE-like protein; Region: YqzE; pfam14038 655816007360 ComG operon protein 7; Region: ComGG; pfam14173 655816007361 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 655816007362 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 655816007363 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 655816007364 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 655816007365 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 655816007366 Type II/IV secretion system protein; Region: T2SE; pfam00437 655816007367 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 655816007368 Walker A motif; other site 655816007369 ATP binding site [chemical binding]; other site 655816007370 Walker B motif; other site 655816007371 FOG: CBS domain [General function prediction only]; Region: COG0517 655816007372 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 655816007373 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 655816007374 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 655816007375 Cl binding site [ion binding]; other site 655816007376 oligomer interface [polypeptide binding]; other site 655816007377 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 655816007378 Domain of unknown function DUF21; Region: DUF21; pfam01595 655816007379 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 655816007380 Transporter associated domain; Region: CorC_HlyC; smart01091 655816007381 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816007382 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 655816007383 ArsC family; Region: ArsC; pfam03960 655816007384 putative catalytic residues [active] 655816007385 thiol/disulfide switch; other site 655816007386 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 655816007387 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 655816007388 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 655816007389 Uncharacterized conserved protein [Function unknown]; Region: COG0011 655816007390 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 655816007391 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 655816007392 putative active site [active] 655816007393 Zn binding site [ion binding]; other site 655816007394 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 655816007395 Sulfatase; Region: Sulfatase; pfam00884 655816007396 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 655816007397 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655816007398 nucleotide binding site [chemical binding]; other site 655816007399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 655816007400 Rhomboid family; Region: Rhomboid; pfam01694 655816007401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816007402 binding surface 655816007403 Tetratricopeptide repeat; Region: TPR_16; pfam13432 655816007404 TPR motif; other site 655816007405 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 655816007406 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 655816007407 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 655816007408 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816007409 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 655816007410 YceG-like family; Region: YceG; pfam02618 655816007411 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 655816007412 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 655816007413 Walker A/P-loop; other site 655816007414 ATP binding site [chemical binding]; other site 655816007415 Q-loop/lid; other site 655816007416 ABC transporter signature motif; other site 655816007417 Walker B; other site 655816007418 D-loop; other site 655816007419 H-loop/switch region; other site 655816007420 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 655816007421 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 655816007422 Walker A/P-loop; other site 655816007423 ATP binding site [chemical binding]; other site 655816007424 Q-loop/lid; other site 655816007425 ABC transporter signature motif; other site 655816007426 Walker B; other site 655816007427 D-loop; other site 655816007428 H-loop/switch region; other site 655816007429 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 655816007430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816007431 dimer interface [polypeptide binding]; other site 655816007432 conserved gate region; other site 655816007433 ABC-ATPase subunit interface; other site 655816007434 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 655816007435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816007436 dimer interface [polypeptide binding]; other site 655816007437 conserved gate region; other site 655816007438 putative PBP binding loops; other site 655816007439 ABC-ATPase subunit interface; other site 655816007440 PBP superfamily domain; Region: PBP_like_2; cl17296 655816007441 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 655816007442 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 655816007443 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816007444 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 655816007445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816007446 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816007447 putative substrate translocation pore; other site 655816007448 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 655816007449 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 655816007450 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 655816007451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 655816007452 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 655816007453 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 655816007454 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 655816007455 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 655816007456 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 655816007457 Uncharacterized conserved protein [Function unknown]; Region: COG5663 655816007458 ferric uptake regulator; Provisional; Region: fur; PRK09462 655816007459 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 655816007460 metal binding site 2 [ion binding]; metal-binding site 655816007461 putative DNA binding helix; other site 655816007462 metal binding site 1 [ion binding]; metal-binding site 655816007463 dimer interface [polypeptide binding]; other site 655816007464 structural Zn2+ binding site [ion binding]; other site 655816007465 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816007466 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816007467 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816007468 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 655816007469 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 655816007470 endonuclease IV; Provisional; Region: PRK01060 655816007471 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 655816007472 AP (apurinic/apyrimidinic) site pocket; other site 655816007473 DNA interaction; other site 655816007474 Metal-binding active site; metal-binding site 655816007475 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 655816007476 DEAD-like helicases superfamily; Region: DEXDc; smart00487 655816007477 ATP binding site [chemical binding]; other site 655816007478 Mg++ binding site [ion binding]; other site 655816007479 motif III; other site 655816007480 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816007481 nucleotide binding region [chemical binding]; other site 655816007482 ATP-binding site [chemical binding]; other site 655816007483 YqfQ-like protein; Region: YqfQ; pfam14181 655816007484 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 655816007485 LytB protein; Region: LYTB; pfam02401 655816007486 Uncharacterized conserved protein [Function unknown]; Region: COG0327 655816007487 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 655816007488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 655816007489 Uncharacterized conserved protein [Function unknown]; Region: COG0327 655816007490 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 655816007491 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 655816007492 Family of unknown function (DUF633); Region: DUF633; pfam04816 655816007493 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 655816007494 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 655816007495 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 655816007496 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 655816007497 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 655816007498 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816007499 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 655816007500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816007501 DNA binding residues [nucleotide binding] 655816007502 DNA primase; Validated; Region: dnaG; PRK05667 655816007503 CHC2 zinc finger; Region: zf-CHC2; pfam01807 655816007504 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 655816007505 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 655816007506 active site 655816007507 metal binding site [ion binding]; metal-binding site 655816007508 interdomain interaction site; other site 655816007509 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 655816007510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 655816007511 PEP synthetase regulatory protein; Provisional; Region: PRK05339 655816007512 HTH domain; Region: HTH_11; pfam08279 655816007513 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 655816007514 FOG: CBS domain [General function prediction only]; Region: COG0517 655816007515 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 655816007516 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 655816007517 dimer interface [polypeptide binding]; other site 655816007518 motif 1; other site 655816007519 active site 655816007520 motif 2; other site 655816007521 motif 3; other site 655816007522 Recombination protein O N terminal; Region: RecO_N; pfam11967 655816007523 DNA repair protein RecO; Region: reco; TIGR00613 655816007524 Recombination protein O C terminal; Region: RecO_C; pfam02565 655816007525 YqzL-like protein; Region: YqzL; pfam14006 655816007526 GTPase Era; Reviewed; Region: era; PRK00089 655816007527 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 655816007528 G1 box; other site 655816007529 GTP/Mg2+ binding site [chemical binding]; other site 655816007530 Switch I region; other site 655816007531 G2 box; other site 655816007532 Switch II region; other site 655816007533 G3 box; other site 655816007534 G4 box; other site 655816007535 G5 box; other site 655816007536 KH domain; Region: KH_2; pfam07650 655816007537 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 655816007538 active site 655816007539 catalytic motif [active] 655816007540 Zn binding site [ion binding]; other site 655816007541 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 655816007542 metal-binding heat shock protein; Provisional; Region: PRK00016 655816007543 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 655816007544 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 655816007545 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816007546 Zn2+ binding site [ion binding]; other site 655816007547 Mg2+ binding site [ion binding]; other site 655816007548 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 655816007549 PhoH-like protein; Region: PhoH; pfam02562 655816007550 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 655816007551 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 655816007552 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 655816007553 hypothetical protein; Provisional; Region: PRK13665 655816007554 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 655816007555 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 655816007556 dimer interface [polypeptide binding]; other site 655816007557 active site residues [active] 655816007558 Yqey-like protein; Region: YqeY; pfam09424 655816007559 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 655816007560 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 655816007561 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 655816007562 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 655816007563 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 655816007564 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 655816007565 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816007566 FeS/SAM binding site; other site 655816007567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 655816007568 RNA methyltransferase, RsmE family; Region: TIGR00046 655816007569 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 655816007570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816007571 S-adenosylmethionine binding site [chemical binding]; other site 655816007572 chaperone protein DnaJ; Provisional; Region: PRK14280 655816007573 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 655816007574 HSP70 interaction site [polypeptide binding]; other site 655816007575 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 655816007576 substrate binding site [polypeptide binding]; other site 655816007577 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 655816007578 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 655816007579 dimer interface [polypeptide binding]; other site 655816007580 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 655816007581 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 655816007582 nucleotide binding site [chemical binding]; other site 655816007583 NEF interaction site [polypeptide binding]; other site 655816007584 SBD interface [polypeptide binding]; other site 655816007585 heat shock protein GrpE; Provisional; Region: PRK14140 655816007586 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 655816007587 dimer interface [polypeptide binding]; other site 655816007588 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 655816007589 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 655816007590 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 655816007591 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 655816007592 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816007593 FeS/SAM binding site; other site 655816007594 HemN C-terminal domain; Region: HemN_C; pfam06969 655816007595 GTP-binding protein LepA; Provisional; Region: PRK05433 655816007596 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 655816007597 G1 box; other site 655816007598 putative GEF interaction site [polypeptide binding]; other site 655816007599 GTP/Mg2+ binding site [chemical binding]; other site 655816007600 Switch I region; other site 655816007601 G2 box; other site 655816007602 G3 box; other site 655816007603 Switch II region; other site 655816007604 G4 box; other site 655816007605 G5 box; other site 655816007606 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 655816007607 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 655816007608 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 655816007609 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 655816007610 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 655816007611 stage II sporulation protein P; Region: spore_II_P; TIGR02867 655816007612 germination protease; Provisional; Region: PRK02858 655816007613 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 655816007614 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 655816007615 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 655816007616 YqzM-like protein; Region: YqzM; pfam14141 655816007617 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 655816007618 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 655816007619 Competence protein; Region: Competence; pfam03772 655816007620 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 655816007621 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 655816007622 catalytic motif [active] 655816007623 Zn binding site [ion binding]; other site 655816007624 SLBB domain; Region: SLBB; pfam10531 655816007625 comEA protein; Region: comE; TIGR01259 655816007626 Helix-hairpin-helix motif; Region: HHH; pfam00633 655816007627 late competence protein ComER; Validated; Region: PRK07680 655816007628 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 655816007629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816007630 S-adenosylmethionine binding site [chemical binding]; other site 655816007631 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 655816007632 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816007633 Zn2+ binding site [ion binding]; other site 655816007634 Mg2+ binding site [ion binding]; other site 655816007635 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 655816007636 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 655816007637 active site 655816007638 (T/H)XGH motif; other site 655816007639 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 655816007640 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 655816007641 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 655816007642 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 655816007643 shikimate binding site; other site 655816007644 NAD(P) binding site [chemical binding]; other site 655816007645 GTPase YqeH; Provisional; Region: PRK13796 655816007646 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 655816007647 GTP/Mg2+ binding site [chemical binding]; other site 655816007648 G4 box; other site 655816007649 G5 box; other site 655816007650 G1 box; other site 655816007651 Switch I region; other site 655816007652 G2 box; other site 655816007653 G3 box; other site 655816007654 Switch II region; other site 655816007655 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 655816007656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816007657 active site 655816007658 motif I; other site 655816007659 motif II; other site 655816007660 Sporulation inhibitor A; Region: Sda; pfam08970 655816007661 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 655816007662 active site 655816007663 catalytic triad [active] 655816007664 oxyanion hole [active] 655816007665 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 655816007666 amidase catalytic site [active] 655816007667 Zn binding residues [ion binding]; other site 655816007668 substrate binding site [chemical binding]; other site 655816007669 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 655816007670 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 655816007671 Uncharacterized conserved protein [Function unknown]; Region: COG0398 655816007672 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 655816007673 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 655816007674 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 655816007675 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 655816007676 sporulation sigma factor SigK; Reviewed; Region: PRK05803 655816007677 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816007678 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816007679 DNA binding residues [nucleotide binding] 655816007680 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 655816007681 catalytic nucleophile [active] 655816007682 fumarate hydratase; Reviewed; Region: fumC; PRK00485 655816007683 Class II fumarases; Region: Fumarase_classII; cd01362 655816007684 active site 655816007685 tetramer interface [polypeptide binding]; other site 655816007686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816007687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816007688 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 655816007689 putative dimerization interface [polypeptide binding]; other site 655816007690 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 655816007691 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 655816007692 catalytic nucleophile [active] 655816007693 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 655816007694 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 655816007695 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 655816007696 FMN binding site [chemical binding]; other site 655816007697 substrate binding site [chemical binding]; other site 655816007698 putative catalytic residue [active] 655816007699 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816007700 MarR family; Region: MarR; pfam01047 655816007701 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 655816007702 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 655816007703 Predicted transcriptional regulators [Transcription]; Region: COG1733 655816007704 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816007705 dimerization interface [polypeptide binding]; other site 655816007706 putative DNA binding site [nucleotide binding]; other site 655816007707 putative Zn2+ binding site [ion binding]; other site 655816007708 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 655816007709 dimer interface [polypeptide binding]; other site 655816007710 FMN binding site [chemical binding]; other site 655816007711 NADPH bind site [chemical binding]; other site 655816007712 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 655816007713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816007714 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816007715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816007716 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 655816007717 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 655816007718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816007719 NAD(P) binding site [chemical binding]; other site 655816007720 active site 655816007721 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 655816007722 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 655816007723 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 655816007724 DNA binding residues [nucleotide binding] 655816007725 dimer interface [polypeptide binding]; other site 655816007726 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 655816007727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816007728 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816007729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816007730 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 655816007731 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 655816007732 Transcriptional regulators [Transcription]; Region: FadR; COG2186 655816007733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816007734 DNA-binding site [nucleotide binding]; DNA binding site 655816007735 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 655816007736 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 655816007737 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 655816007738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816007739 D-galactonate transporter; Region: 2A0114; TIGR00893 655816007740 putative substrate translocation pore; other site 655816007741 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 655816007742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816007743 NAD(P) binding site [chemical binding]; other site 655816007744 active site 655816007745 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 655816007746 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 655816007747 PYR/PP interface [polypeptide binding]; other site 655816007748 dimer interface [polypeptide binding]; other site 655816007749 TPP binding site [chemical binding]; other site 655816007750 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655816007751 transketolase; Reviewed; Region: PRK05899 655816007752 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 655816007753 TPP-binding site [chemical binding]; other site 655816007754 dimer interface [polypeptide binding]; other site 655816007755 Protein of unknown function, DUF606; Region: DUF606; pfam04657 655816007756 Protein of unknown function, DUF606; Region: DUF606; pfam04657 655816007757 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816007758 dimerization interface [polypeptide binding]; other site 655816007759 putative DNA binding site [nucleotide binding]; other site 655816007760 putative Zn2+ binding site [ion binding]; other site 655816007761 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 655816007762 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 655816007763 Protein of unknown function (DUF419); Region: DUF419; pfam04237 655816007764 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 655816007765 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 655816007766 active site 655816007767 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 655816007768 YodA lipocalin-like domain; Region: YodA; pfam09223 655816007769 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 655816007770 Bacterial SH3 domain homologues; Region: SH3b; smart00287 655816007771 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 655816007772 Bacterial SH3 domain; Region: SH3_3; cl17532 655816007773 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 655816007774 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 655816007775 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655816007776 NAD binding site [chemical binding]; other site 655816007777 catalytic Zn binding site [ion binding]; other site 655816007778 structural Zn binding site [ion binding]; other site 655816007779 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 655816007780 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 655816007781 dimerization domain swap beta strand [polypeptide binding]; other site 655816007782 regulatory protein interface [polypeptide binding]; other site 655816007783 regulatory phosphorylation site [posttranslational modification]; other site 655816007784 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816007785 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655816007786 active site 655816007787 catalytic tetrad [active] 655816007788 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 655816007789 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 655816007790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816007791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816007792 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 655816007793 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 655816007794 DNA binding residues [nucleotide binding] 655816007795 putative dimer interface [polypeptide binding]; other site 655816007796 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 655816007797 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 655816007798 DNA binding residues [nucleotide binding] 655816007799 putative dimer interface [polypeptide binding]; other site 655816007800 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 655816007801 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 655816007802 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 655816007803 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 655816007804 putative NAD(P) binding site [chemical binding]; other site 655816007805 putative substrate binding site [chemical binding]; other site 655816007806 catalytic Zn binding site [ion binding]; other site 655816007807 structural Zn binding site [ion binding]; other site 655816007808 dimer interface [polypeptide binding]; other site 655816007809 intracellular protease, PfpI family; Region: PfpI; TIGR01382 655816007810 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 655816007811 proposed catalytic triad [active] 655816007812 conserved cys residue [active] 655816007813 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 655816007814 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 655816007815 substrate binding [chemical binding]; other site 655816007816 active site 655816007817 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 655816007818 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 655816007819 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 655816007820 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 655816007821 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 655816007822 active site 655816007823 phosphorylation site [posttranslational modification] 655816007824 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 655816007825 active pocket/dimerization site; other site 655816007826 active site 655816007827 phosphorylation site [posttranslational modification] 655816007828 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 655816007829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816007830 Walker A motif; other site 655816007831 ATP binding site [chemical binding]; other site 655816007832 Walker B motif; other site 655816007833 arginine finger; other site 655816007834 Transcriptional antiterminator [Transcription]; Region: COG3933 655816007835 PRD domain; Region: PRD; pfam00874 655816007836 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 655816007837 active pocket/dimerization site; other site 655816007838 active site 655816007839 phosphorylation site [posttranslational modification] 655816007840 PRD domain; Region: PRD; pfam00874 655816007841 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 655816007842 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 655816007843 Predicted transcriptional regulators [Transcription]; Region: COG1378 655816007844 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 655816007845 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 655816007846 C-terminal domain interface [polypeptide binding]; other site 655816007847 sugar binding site [chemical binding]; other site 655816007848 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 655816007849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816007850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816007851 DNA binding residues [nucleotide binding] 655816007852 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 655816007853 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 655816007854 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 655816007855 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 655816007856 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 655816007857 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 655816007858 catalytic triad [active] 655816007859 catalytic triad [active] 655816007860 oxyanion hole [active] 655816007861 YrhK-like protein; Region: YrhK; pfam14145 655816007862 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 655816007863 Cytochrome P450; Region: p450; pfam00067 655816007864 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 655816007865 Flavodoxin; Region: Flavodoxin_1; pfam00258 655816007866 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 655816007867 FAD binding pocket [chemical binding]; other site 655816007868 FAD binding motif [chemical binding]; other site 655816007869 catalytic residues [active] 655816007870 NAD binding pocket [chemical binding]; other site 655816007871 phosphate binding motif [ion binding]; other site 655816007872 beta-alpha-beta structure motif; other site 655816007873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816007874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816007875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816007876 S-adenosylmethionine binding site [chemical binding]; other site 655816007877 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 655816007878 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 655816007879 Uncharacterized conserved protein [Function unknown]; Region: COG5609 655816007880 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 655816007881 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 655816007882 catalytic loop [active] 655816007883 iron binding site [ion binding]; other site 655816007884 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 655816007885 4Fe-4S binding domain; Region: Fer4; pfam00037 655816007886 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 655816007887 [4Fe-4S] binding site [ion binding]; other site 655816007888 molybdopterin cofactor binding site; other site 655816007889 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 655816007890 molybdopterin cofactor binding site; other site 655816007891 Uncharacterized conserved protein [Function unknown]; Region: COG2427 655816007892 YrhC-like protein; Region: YrhC; pfam14143 655816007893 cystathionine beta-lyase; Provisional; Region: PRK07671 655816007894 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 655816007895 homodimer interface [polypeptide binding]; other site 655816007896 substrate-cofactor binding pocket; other site 655816007897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816007898 catalytic residue [active] 655816007899 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 655816007900 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 655816007901 dimer interface [polypeptide binding]; other site 655816007902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816007903 catalytic residue [active] 655816007904 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 655816007905 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 655816007906 Methyltransferase domain; Region: Methyltransf_23; pfam13489 655816007907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816007908 S-adenosylmethionine binding site [chemical binding]; other site 655816007909 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 655816007910 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 655816007911 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 655816007912 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816007913 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 655816007914 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 655816007915 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 655816007916 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 655816007917 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 655816007918 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 655816007919 ATP-binding site [chemical binding]; other site 655816007920 Sugar specificity; other site 655816007921 Pyrimidine base specificity; other site 655816007922 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 655816007923 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 655816007924 Peptidase family U32; Region: Peptidase_U32; pfam01136 655816007925 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 655816007926 Peptidase family U32; Region: Peptidase_U32; pfam01136 655816007927 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 655816007928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816007929 S-adenosylmethionine binding site [chemical binding]; other site 655816007930 conserved hypothetical protein, YceG family; Region: TIGR00247 655816007931 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 655816007932 dimerization interface [polypeptide binding]; other site 655816007933 hypothetical protein; Provisional; Region: PRK13678 655816007934 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 655816007935 hypothetical protein; Provisional; Region: PRK05473 655816007936 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 655816007937 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 655816007938 motif 1; other site 655816007939 active site 655816007940 motif 2; other site 655816007941 motif 3; other site 655816007942 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 655816007943 DHHA1 domain; Region: DHHA1; pfam02272 655816007944 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 655816007945 Domain of unknown function DUF20; Region: UPF0118; pfam01594 655816007946 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 655816007947 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 655816007948 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 655816007949 AAA domain; Region: AAA_30; pfam13604 655816007950 Family description; Region: UvrD_C_2; pfam13538 655816007951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816007952 binding surface 655816007953 TPR motif; other site 655816007954 TPR repeat; Region: TPR_11; pfam13414 655816007955 TPR repeat; Region: TPR_11; pfam13414 655816007956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816007957 binding surface 655816007958 TPR motif; other site 655816007959 TPR repeat; Region: TPR_11; pfam13414 655816007960 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 655816007961 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 655816007962 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 655816007963 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 655816007964 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816007965 catalytic residue [active] 655816007966 Predicted transcriptional regulator [Transcription]; Region: COG1959 655816007967 Transcriptional regulator; Region: Rrf2; pfam02082 655816007968 recombination factor protein RarA; Reviewed; Region: PRK13342 655816007969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816007970 Walker A motif; other site 655816007971 ATP binding site [chemical binding]; other site 655816007972 Walker B motif; other site 655816007973 arginine finger; other site 655816007974 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 655816007975 Integrase core domain; Region: rve; pfam00665 655816007976 Integrase core domain; Region: rve_3; pfam13683 655816007977 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 655816007978 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 655816007979 putative ATP binding site [chemical binding]; other site 655816007980 putative substrate interface [chemical binding]; other site 655816007981 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 655816007982 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 655816007983 dimer interface [polypeptide binding]; other site 655816007984 anticodon binding site; other site 655816007985 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 655816007986 homodimer interface [polypeptide binding]; other site 655816007987 motif 1; other site 655816007988 active site 655816007989 motif 2; other site 655816007990 GAD domain; Region: GAD; pfam02938 655816007991 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 655816007992 motif 3; other site 655816007993 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 655816007994 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 655816007995 dimer interface [polypeptide binding]; other site 655816007996 motif 1; other site 655816007997 active site 655816007998 motif 2; other site 655816007999 motif 3; other site 655816008000 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 655816008001 anticodon binding site; other site 655816008002 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 655816008003 Bacterial SH3 domain homologues; Region: SH3b; smart00287 655816008004 Bacterial SH3 domain; Region: SH3_3; pfam08239 655816008005 Bacterial SH3 domain; Region: SH3_3; pfam08239 655816008006 Bacterial SH3 domain homologues; Region: SH3b; smart00287 655816008007 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 655816008008 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 655816008009 active site 655816008010 metal binding site [ion binding]; metal-binding site 655816008011 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 655816008012 putative active site [active] 655816008013 dimerization interface [polypeptide binding]; other site 655816008014 putative tRNAtyr binding site [nucleotide binding]; other site 655816008015 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 655816008016 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816008017 Zn2+ binding site [ion binding]; other site 655816008018 Mg2+ binding site [ion binding]; other site 655816008019 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 655816008020 synthetase active site [active] 655816008021 NTP binding site [chemical binding]; other site 655816008022 metal binding site [ion binding]; metal-binding site 655816008023 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 655816008024 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 655816008025 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816008026 active site 655816008027 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 655816008028 DHH family; Region: DHH; pfam01368 655816008029 DHHA1 domain; Region: DHHA1; pfam02272 655816008030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 655816008031 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 655816008032 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 655816008033 TrkA-C domain; Region: TrkA_C; pfam02080 655816008034 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 655816008035 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 655816008036 Protein export membrane protein; Region: SecD_SecF; pfam02355 655816008037 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 655816008038 stage V sporulation protein B; Region: spore_V_B; TIGR02900 655816008039 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 655816008040 Predicted membrane protein [Function unknown]; Region: COG2323 655816008041 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 655816008042 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 655816008043 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 655816008044 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 655816008045 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 655816008046 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 655816008047 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 655816008048 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 655816008049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816008050 Walker A motif; other site 655816008051 ATP binding site [chemical binding]; other site 655816008052 Walker B motif; other site 655816008053 arginine finger; other site 655816008054 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 655816008055 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 655816008056 RuvA N terminal domain; Region: RuvA_N; pfam01330 655816008057 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 655816008058 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 655816008059 BofC C-terminal domain; Region: BofC_C; pfam08955 655816008060 polyol permease family; Region: 2A0118; TIGR00897 655816008061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816008062 putative substrate translocation pore; other site 655816008063 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816008064 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655816008065 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 655816008066 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 655816008067 active site 655816008068 substrate binding site [chemical binding]; other site 655816008069 ATP binding site [chemical binding]; other site 655816008070 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 655816008071 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 655816008072 hypothetical protein; Validated; Region: PRK00110 655816008073 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 655816008074 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816008075 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 655816008076 quinolinate synthetase; Provisional; Region: PRK09375 655816008077 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 655816008078 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 655816008079 dimerization interface [polypeptide binding]; other site 655816008080 active site 655816008081 L-aspartate oxidase; Provisional; Region: PRK08071 655816008082 L-aspartate oxidase; Provisional; Region: PRK06175 655816008083 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 655816008084 cysteine desulfurase; Provisional; Region: PRK02948 655816008085 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 655816008086 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816008087 catalytic residue [active] 655816008088 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 655816008089 HTH domain; Region: HTH_11; pfam08279 655816008090 3H domain; Region: 3H; pfam02829 655816008091 prephenate dehydratase; Provisional; Region: PRK11898 655816008092 Prephenate dehydratase; Region: PDT; pfam00800 655816008093 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 655816008094 putative L-Phe binding site [chemical binding]; other site 655816008095 hypothetical protein; Provisional; Region: PRK04435 655816008096 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 655816008097 GTPase CgtA; Reviewed; Region: obgE; PRK12297 655816008098 GTP1/OBG; Region: GTP1_OBG; pfam01018 655816008099 Obg GTPase; Region: Obg; cd01898 655816008100 G1 box; other site 655816008101 GTP/Mg2+ binding site [chemical binding]; other site 655816008102 Switch I region; other site 655816008103 G2 box; other site 655816008104 G3 box; other site 655816008105 Switch II region; other site 655816008106 G4 box; other site 655816008107 G5 box; other site 655816008108 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 655816008109 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 655816008110 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 655816008111 hypothetical protein; Provisional; Region: PRK14553 655816008112 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 655816008113 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 655816008114 L21 leader; ribosomal protein gene, untranslated leader autoregulatory structure; BSUW23_misc_RNA_43 655816008115 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 655816008116 active site 655816008117 Peptidase family M50; Region: Peptidase_M50; pfam02163 655816008118 putative substrate binding region [chemical binding]; other site 655816008119 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 655816008120 Peptidase family M23; Region: Peptidase_M23; pfam01551 655816008121 septum site-determining protein MinD; Region: minD_bact; TIGR01968 655816008122 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 655816008123 Switch I; other site 655816008124 Switch II; other site 655816008125 septum formation inhibitor; Reviewed; Region: minC; PRK00513 655816008126 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 655816008127 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 655816008128 rod shape-determining protein MreC; Region: mreC; TIGR00219 655816008129 rod shape-determining protein MreC; Region: MreC; pfam04085 655816008130 rod shape-determining protein MreB; Provisional; Region: PRK13927 655816008131 MreB and similar proteins; Region: MreB_like; cd10225 655816008132 nucleotide binding site [chemical binding]; other site 655816008133 Mg binding site [ion binding]; other site 655816008134 putative protofilament interaction site [polypeptide binding]; other site 655816008135 RodZ interaction site [polypeptide binding]; other site 655816008136 hypothetical protein; Reviewed; Region: PRK00024 655816008137 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 655816008138 MPN+ (JAMM) motif; other site 655816008139 Zinc-binding site [ion binding]; other site 655816008140 Maf-like protein; Region: Maf; pfam02545 655816008141 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 655816008142 active site 655816008143 dimer interface [polypeptide binding]; other site 655816008144 Sporulation related domain; Region: SPOR; pfam05036 655816008145 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 655816008146 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 655816008147 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 655816008148 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 655816008149 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655816008150 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655816008151 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 655816008152 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 655816008153 active site 655816008154 HIGH motif; other site 655816008155 nucleotide binding site [chemical binding]; other site 655816008156 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 655816008157 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 655816008158 active site 655816008159 KMSKS motif; other site 655816008160 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 655816008161 tRNA binding surface [nucleotide binding]; other site 655816008162 anticodon binding site; other site 655816008163 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 655816008164 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 655816008165 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 655816008166 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655816008167 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 655816008168 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816008169 inhibitor-cofactor binding pocket; inhibition site 655816008170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816008171 catalytic residue [active] 655816008172 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 655816008173 dimer interface [polypeptide binding]; other site 655816008174 active site 655816008175 Schiff base residues; other site 655816008176 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 655816008177 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 655816008178 active site 655816008179 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 655816008180 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 655816008181 domain interfaces; other site 655816008182 active site 655816008183 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 655816008184 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 655816008185 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 655816008186 tRNA; other site 655816008187 putative tRNA binding site [nucleotide binding]; other site 655816008188 putative NADP binding site [chemical binding]; other site 655816008189 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 655816008190 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 655816008191 G1 box; other site 655816008192 GTP/Mg2+ binding site [chemical binding]; other site 655816008193 Switch I region; other site 655816008194 G2 box; other site 655816008195 G3 box; other site 655816008196 Switch II region; other site 655816008197 G4 box; other site 655816008198 G5 box; other site 655816008199 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 655816008200 Found in ATP-dependent protease La (LON); Region: LON; smart00464 655816008201 Found in ATP-dependent protease La (LON); Region: LON; smart00464 655816008202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816008203 Walker A motif; other site 655816008204 ATP binding site [chemical binding]; other site 655816008205 Walker B motif; other site 655816008206 arginine finger; other site 655816008207 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 655816008208 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 655816008209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816008210 Walker A motif; other site 655816008211 ATP binding site [chemical binding]; other site 655816008212 Walker B motif; other site 655816008213 arginine finger; other site 655816008214 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 655816008215 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 655816008216 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 655816008217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816008218 Walker A motif; other site 655816008219 ATP binding site [chemical binding]; other site 655816008220 Walker B motif; other site 655816008221 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 655816008222 trigger factor; Provisional; Region: tig; PRK01490 655816008223 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 655816008224 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 655816008225 TPR repeat; Region: TPR_11; pfam13414 655816008226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816008227 binding surface 655816008228 TPR motif; other site 655816008229 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 655816008230 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 655816008231 hypothetical protein; Provisional; Region: PRK14812 655816008232 substrate binding site [chemical binding]; other site 655816008233 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 655816008234 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 655816008235 substrate binding site [chemical binding]; other site 655816008236 ligand binding site [chemical binding]; other site 655816008237 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 655816008238 tartrate dehydrogenase; Region: TTC; TIGR02089 655816008239 2-isopropylmalate synthase; Validated; Region: PRK00915 655816008240 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 655816008241 active site 655816008242 catalytic residues [active] 655816008243 metal binding site [ion binding]; metal-binding site 655816008244 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 655816008245 ketol-acid reductoisomerase; Provisional; Region: PRK05479 655816008246 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 655816008247 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 655816008248 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 655816008249 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 655816008250 putative valine binding site [chemical binding]; other site 655816008251 dimer interface [polypeptide binding]; other site 655816008252 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 655816008253 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 655816008254 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 655816008255 PYR/PP interface [polypeptide binding]; other site 655816008256 dimer interface [polypeptide binding]; other site 655816008257 TPP binding site [chemical binding]; other site 655816008258 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 655816008259 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 655816008260 TPP-binding site [chemical binding]; other site 655816008261 dimer interface [polypeptide binding]; other site 655816008262 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 655816008263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816008264 Coenzyme A binding pocket [chemical binding]; other site 655816008265 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 655816008266 Kelch motif; Region: Kelch_1; pfam01344 655816008267 Kelch motif; Region: Kelch_1; pfam01344 655816008268 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 655816008269 Kelch motif; Region: Kelch_1; pfam01344 655816008270 Heat induced stress protein YflT; Region: YflT; pfam11181 655816008271 conserved domain; Region: TIGR02271 655816008272 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 655816008273 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655816008274 active site 655816008275 metal binding site [ion binding]; metal-binding site 655816008276 homotetramer interface [polypeptide binding]; other site 655816008277 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 655816008278 active site 655816008279 dimerization interface [polypeptide binding]; other site 655816008280 ribonuclease PH; Reviewed; Region: rph; PRK00173 655816008281 Ribonuclease PH; Region: RNase_PH_bact; cd11362 655816008282 hexamer interface [polypeptide binding]; other site 655816008283 active site 655816008284 Spore germination protein [General function prediction only]; Region: COG5401 655816008285 Sporulation and spore germination; Region: Germane; pfam10646 655816008286 Sporulation and spore germination; Region: Germane; pfam10646 655816008287 glutamate racemase; Region: glut_race; TIGR00067 655816008288 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816008289 MarR family; Region: MarR; pfam01047 655816008290 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816008291 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816008292 DNA binding residues [nucleotide binding] 655816008293 dimerization interface [polypeptide binding]; other site 655816008294 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 655816008295 active site 655816008296 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 655816008297 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 655816008298 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 655816008299 L-aspartate oxidase; Provisional; Region: PRK06175 655816008300 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 655816008301 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 655816008302 putative Iron-sulfur protein interface [polypeptide binding]; other site 655816008303 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 655816008304 proximal heme binding site [chemical binding]; other site 655816008305 distal heme binding site [chemical binding]; other site 655816008306 putative dimer interface [polypeptide binding]; other site 655816008307 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 655816008308 aspartate kinase; Reviewed; Region: PRK06635 655816008309 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 655816008310 putative nucleotide binding site [chemical binding]; other site 655816008311 putative catalytic residues [active] 655816008312 putative Mg ion binding site [ion binding]; other site 655816008313 putative aspartate binding site [chemical binding]; other site 655816008314 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 655816008315 putative allosteric regulatory site; other site 655816008316 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 655816008317 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 655816008318 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 655816008319 GIY-YIG motif/motif A; other site 655816008320 active site 655816008321 catalytic site [active] 655816008322 putative DNA binding site [nucleotide binding]; other site 655816008323 metal binding site [ion binding]; metal-binding site 655816008324 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 655816008325 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 655816008326 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 655816008327 catalytic residues [active] 655816008328 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 655816008329 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 655816008330 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 655816008331 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 655816008332 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 655816008333 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 655816008334 Ligand binding site [chemical binding]; other site 655816008335 Electron transfer flavoprotein domain; Region: ETF; pfam01012 655816008336 enoyl-CoA hydratase; Provisional; Region: PRK07658 655816008337 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816008338 substrate binding site [chemical binding]; other site 655816008339 oxyanion hole (OAH) forming residues; other site 655816008340 trimer interface [polypeptide binding]; other site 655816008341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816008342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816008343 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 655816008344 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 655816008345 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 655816008346 acyl-activating enzyme (AAE) consensus motif; other site 655816008347 putative AMP binding site [chemical binding]; other site 655816008348 putative active site [active] 655816008349 putative CoA binding site [chemical binding]; other site 655816008350 Predicted membrane protein [Function unknown]; Region: COG3766 655816008351 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 655816008352 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 655816008353 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 655816008354 MutS domain III; Region: MutS_III; pfam05192 655816008355 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 655816008356 Walker A/P-loop; other site 655816008357 ATP binding site [chemical binding]; other site 655816008358 Q-loop/lid; other site 655816008359 ABC transporter signature motif; other site 655816008360 Walker B; other site 655816008361 D-loop; other site 655816008362 H-loop/switch region; other site 655816008363 Smr domain; Region: Smr; pfam01713 655816008364 hypothetical protein; Provisional; Region: PRK08609 655816008365 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 655816008366 active site 655816008367 primer binding site [nucleotide binding]; other site 655816008368 NTP binding site [chemical binding]; other site 655816008369 metal binding triad [ion binding]; metal-binding site 655816008370 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 655816008371 active site 655816008372 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 655816008373 Colicin V production protein; Region: Colicin_V; pfam02674 655816008374 cell division protein ZapA; Provisional; Region: PRK14126 655816008375 ribonuclease HIII; Provisional; Region: PRK00996 655816008376 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 655816008377 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 655816008378 RNA/DNA hybrid binding site [nucleotide binding]; other site 655816008379 active site 655816008380 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 655816008381 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 655816008382 putative tRNA-binding site [nucleotide binding]; other site 655816008383 B3/4 domain; Region: B3_4; pfam03483 655816008384 tRNA synthetase B5 domain; Region: B5; smart00874 655816008385 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 655816008386 dimer interface [polypeptide binding]; other site 655816008387 motif 1; other site 655816008388 motif 3; other site 655816008389 motif 2; other site 655816008390 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 655816008391 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 655816008392 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 655816008393 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 655816008394 dimer interface [polypeptide binding]; other site 655816008395 motif 1; other site 655816008396 active site 655816008397 motif 2; other site 655816008398 motif 3; other site 655816008399 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 655816008400 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 655816008401 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 655816008402 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 655816008403 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 655816008404 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 655816008405 active site 655816008406 catalytic site [active] 655816008407 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 655816008408 FAD binding domain; Region: FAD_binding_4; pfam01565 655816008409 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 655816008410 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 655816008411 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 655816008412 Cysteine-rich domain; Region: CCG; pfam02754 655816008413 Cysteine-rich domain; Region: CCG; pfam02754 655816008414 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 655816008415 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816008416 active site 655816008417 metal binding site [ion binding]; metal-binding site 655816008418 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 655816008419 Carbon starvation protein CstA; Region: CstA; pfam02554 655816008420 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 655816008421 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 655816008422 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 655816008423 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 655816008424 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 655816008425 Predicted transcriptional regulators [Transcription]; Region: COG1695 655816008426 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 655816008427 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 655816008428 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 655816008429 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655816008430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816008431 putative PBP binding loops; other site 655816008432 dimer interface [polypeptide binding]; other site 655816008433 ABC-ATPase subunit interface; other site 655816008434 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 655816008435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816008436 dimer interface [polypeptide binding]; other site 655816008437 conserved gate region; other site 655816008438 putative PBP binding loops; other site 655816008439 ABC-ATPase subunit interface; other site 655816008440 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 655816008441 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 655816008442 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 655816008443 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 655816008444 active site 655816008445 metal binding site [ion binding]; metal-binding site 655816008446 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 655816008447 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816008448 active site 655816008449 motif I; other site 655816008450 motif II; other site 655816008451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816008452 motif II; other site 655816008453 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 655816008454 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 655816008455 intersubunit interface [polypeptide binding]; other site 655816008456 active site 655816008457 Zn2+ binding site [ion binding]; other site 655816008458 L-ribulokinase; Region: L-ribulokinase; TIGR01234 655816008459 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 655816008460 N- and C-terminal domain interface [polypeptide binding]; other site 655816008461 active site 655816008462 MgATP binding site [chemical binding]; other site 655816008463 catalytic site [active] 655816008464 metal binding site [ion binding]; metal-binding site 655816008465 carbohydrate binding site [chemical binding]; other site 655816008466 homodimer interface [polypeptide binding]; other site 655816008467 L-arabinose isomerase; Provisional; Region: PRK02929 655816008468 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 655816008469 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 655816008470 trimer interface [polypeptide binding]; other site 655816008471 putative substrate binding site [chemical binding]; other site 655816008472 putative metal binding site [ion binding]; other site 655816008473 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 655816008474 substrate binding site [chemical binding]; other site 655816008475 active site 655816008476 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 655816008477 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 655816008478 oligomer interface [polypeptide binding]; other site 655816008479 active site 655816008480 metal binding site [ion binding]; metal-binding site 655816008481 Predicted membrane protein [Function unknown]; Region: COG3326 655816008482 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 655816008483 23S rRNA binding site [nucleotide binding]; other site 655816008484 L21 binding site [polypeptide binding]; other site 655816008485 L13 binding site [polypeptide binding]; other site 655816008486 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 655816008487 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 655816008488 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 655816008489 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 655816008490 L20 leader; ribosomal protein operon infC-rpmI-rplT, untranslated leader autoregulatory structure; BSUW23_misc_RNA_47 655816008491 antiholin-like protein LrgB; Provisional; Region: PRK04288 655816008492 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 655816008493 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 655816008494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816008495 active site 655816008496 phosphorylation site [posttranslational modification] 655816008497 intermolecular recognition site; other site 655816008498 dimerization interface [polypeptide binding]; other site 655816008499 LytTr DNA-binding domain; Region: LytTR; pfam04397 655816008500 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 655816008501 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 655816008502 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 655816008503 Histidine kinase; Region: His_kinase; pfam06580 655816008504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816008505 ATP binding site [chemical binding]; other site 655816008506 Mg2+ binding site [ion binding]; other site 655816008507 G-X-G motif; other site 655816008508 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 655816008509 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816008510 motif II; other site 655816008511 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 655816008512 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 655816008513 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 655816008514 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 655816008515 active site 655816008516 dimer interface [polypeptide binding]; other site 655816008517 motif 1; other site 655816008518 motif 2; other site 655816008519 motif 3; other site 655816008520 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 655816008521 anticodon binding site; other site 655816008522 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 655816008523 Uncharacterized conserved protein [Function unknown]; Region: COG0398 655816008524 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 655816008525 primosomal protein DnaI; Reviewed; Region: PRK08939 655816008526 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 655816008527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816008528 Walker A motif; other site 655816008529 ATP binding site [chemical binding]; other site 655816008530 Walker B motif; other site 655816008531 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 655816008532 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 655816008533 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 655816008534 ATP cone domain; Region: ATP-cone; pfam03477 655816008535 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 655816008536 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 655816008537 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 655816008538 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 655816008539 Predicted transcriptional regulators [Transcription]; Region: COG1733 655816008540 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 655816008541 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 655816008542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816008543 putative substrate translocation pore; other site 655816008544 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816008545 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655816008546 active site 655816008547 catalytic tetrad [active] 655816008548 dephospho-CoA kinase; Region: TIGR00152 655816008549 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 655816008550 CoA-binding site [chemical binding]; other site 655816008551 ATP-binding [chemical binding]; other site 655816008552 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 655816008553 Domain of unknown function DUF; Region: DUF204; pfam02659 655816008554 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 655816008555 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 655816008556 DNA binding site [nucleotide binding] 655816008557 catalytic residue [active] 655816008558 H2TH interface [polypeptide binding]; other site 655816008559 putative catalytic residues [active] 655816008560 turnover-facilitating residue; other site 655816008561 intercalation triad [nucleotide binding]; other site 655816008562 8OG recognition residue [nucleotide binding]; other site 655816008563 putative reading head residues; other site 655816008564 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 655816008565 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 655816008566 DNA polymerase I; Provisional; Region: PRK05755 655816008567 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 655816008568 active site 655816008569 metal binding site 1 [ion binding]; metal-binding site 655816008570 putative 5' ssDNA interaction site; other site 655816008571 metal binding site 3; metal-binding site 655816008572 metal binding site 2 [ion binding]; metal-binding site 655816008573 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 655816008574 putative DNA binding site [nucleotide binding]; other site 655816008575 putative metal binding site [ion binding]; other site 655816008576 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 655816008577 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 655816008578 active site 655816008579 DNA binding site [nucleotide binding] 655816008580 catalytic site [active] 655816008581 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 655816008582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816008583 putative active site [active] 655816008584 heme pocket [chemical binding]; other site 655816008585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816008586 dimer interface [polypeptide binding]; other site 655816008587 phosphorylation site [posttranslational modification] 655816008588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816008589 ATP binding site [chemical binding]; other site 655816008590 Mg2+ binding site [ion binding]; other site 655816008591 G-X-G motif; other site 655816008592 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816008593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816008594 active site 655816008595 phosphorylation site [posttranslational modification] 655816008596 intermolecular recognition site; other site 655816008597 dimerization interface [polypeptide binding]; other site 655816008598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816008599 DNA binding site [nucleotide binding] 655816008600 malate dehydrogenase; Reviewed; Region: PRK06223 655816008601 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 655816008602 NAD(P) binding site [chemical binding]; other site 655816008603 dimer interface [polypeptide binding]; other site 655816008604 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816008605 substrate binding site [chemical binding]; other site 655816008606 isocitrate dehydrogenase; Reviewed; Region: PRK07006 655816008607 isocitrate dehydrogenase; Validated; Region: PRK07362 655816008608 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 655816008609 dimer interface [polypeptide binding]; other site 655816008610 Citrate synthase; Region: Citrate_synt; pfam00285 655816008611 active site 655816008612 citrylCoA binding site [chemical binding]; other site 655816008613 oxalacetate/citrate binding site [chemical binding]; other site 655816008614 coenzyme A binding site [chemical binding]; other site 655816008615 catalytic triad [active] 655816008616 Predicted membrane protein [Function unknown]; Region: COG2707 655816008617 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 655816008618 Domain of unknown function DUF20; Region: UPF0118; pfam01594 655816008619 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 655816008620 pyruvate kinase; Provisional; Region: PRK06354 655816008621 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 655816008622 domain interfaces; other site 655816008623 active site 655816008624 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 655816008625 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 655816008626 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 655816008627 active site 655816008628 ADP/pyrophosphate binding site [chemical binding]; other site 655816008629 dimerization interface [polypeptide binding]; other site 655816008630 allosteric effector site; other site 655816008631 fructose-1,6-bisphosphate binding site; other site 655816008632 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 655816008633 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 655816008634 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 655816008635 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 655816008636 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 655816008637 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 655816008638 Malic enzyme, N-terminal domain; Region: malic; pfam00390 655816008639 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 655816008640 putative NAD(P) binding site [chemical binding]; other site 655816008641 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 655816008642 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 655816008643 active site 655816008644 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 655816008645 generic binding surface I; other site 655816008646 generic binding surface II; other site 655816008647 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 655816008648 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 655816008649 DHH family; Region: DHH; pfam01368 655816008650 DHHA1 domain; Region: DHHA1; pfam02272 655816008651 YtpI-like protein; Region: YtpI; pfam14007 655816008652 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 655816008653 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816008654 DNA-binding site [nucleotide binding]; DNA binding site 655816008655 DRTGG domain; Region: DRTGG; pfam07085 655816008656 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 655816008657 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 655816008658 active site 2 [active] 655816008659 active site 1 [active] 655816008660 metal-dependent hydrolase; Provisional; Region: PRK00685 655816008661 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 655816008662 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 655816008663 classical (c) SDRs; Region: SDR_c; cd05233 655816008664 NAD(P) binding site [chemical binding]; other site 655816008665 active site 655816008666 argininosuccinate lyase; Provisional; Region: PRK00855 655816008667 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 655816008668 active sites [active] 655816008669 tetramer interface [polypeptide binding]; other site 655816008670 argininosuccinate synthase; Provisional; Region: PRK13820 655816008671 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 655816008672 ANP binding site [chemical binding]; other site 655816008673 Substrate Binding Site II [chemical binding]; other site 655816008674 Substrate Binding Site I [chemical binding]; other site 655816008675 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 655816008676 MPT binding site; other site 655816008677 trimer interface [polypeptide binding]; other site 655816008678 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 655816008679 propionate/acetate kinase; Provisional; Region: PRK12379 655816008680 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 655816008681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816008682 S-adenosylmethionine binding site [chemical binding]; other site 655816008683 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 655816008684 dimer interface [polypeptide binding]; other site 655816008685 catalytic triad [active] 655816008686 peroxidatic and resolving cysteines [active] 655816008687 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 655816008688 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 655816008689 Predicted membrane protein/domain [Function unknown]; Region: COG1714 655816008690 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 655816008691 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 655816008692 tandem repeat interface [polypeptide binding]; other site 655816008693 oligomer interface [polypeptide binding]; other site 655816008694 active site residues [active] 655816008695 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 655816008696 ATP-NAD kinase; Region: NAD_kinase; pfam01513 655816008697 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 655816008698 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 655816008699 active site 655816008700 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 655816008701 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 655816008702 active site 655816008703 acyl-activating enzyme (AAE) consensus motif; other site 655816008704 putative CoA binding site [chemical binding]; other site 655816008705 AMP binding site [chemical binding]; other site 655816008706 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 655816008707 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 655816008708 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 655816008709 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 655816008710 Ligand Binding Site [chemical binding]; other site 655816008711 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 655816008712 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 655816008713 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816008714 catalytic residue [active] 655816008715 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 655816008716 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 655816008717 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 655816008718 oligomer interface [polypeptide binding]; other site 655816008719 histidinol-phosphatase; Reviewed; Region: PRK08123 655816008720 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 655816008721 active site 655816008722 dimer interface [polypeptide binding]; other site 655816008723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816008724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816008725 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 655816008726 GAF domain; Region: GAF_2; pfam13185 655816008727 GAF domain; Region: GAF_3; pfam13492 655816008728 GAF domain; Region: GAF_3; pfam13492 655816008729 GAF domain; Region: GAF_2; pfam13185 655816008730 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 655816008731 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655816008732 metal binding site [ion binding]; metal-binding site 655816008733 active site 655816008734 I-site; other site 655816008735 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 655816008736 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 655816008737 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816008738 RNA binding surface [nucleotide binding]; other site 655816008739 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 655816008740 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 655816008741 active site 655816008742 HIGH motif; other site 655816008743 dimer interface [polypeptide binding]; other site 655816008744 KMSKS motif; other site 655816008745 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816008746 RNA binding surface [nucleotide binding]; other site 655816008747 acetyl-CoA synthetase; Provisional; Region: PRK04319 655816008748 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 655816008749 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 655816008750 active site 655816008751 acyl-activating enzyme (AAE) consensus motif; other site 655816008752 putative CoA binding site [chemical binding]; other site 655816008753 AMP binding site [chemical binding]; other site 655816008754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816008755 Coenzyme A binding pocket [chemical binding]; other site 655816008756 FOG: CBS domain [General function prediction only]; Region: COG0517 655816008757 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 655816008758 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 655816008759 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 655816008760 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 655816008761 active site 655816008762 Zn binding site [ion binding]; other site 655816008763 flagellar motor protein MotS; Reviewed; Region: PRK06925 655816008764 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 655816008765 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 655816008766 ligand binding site [chemical binding]; other site 655816008767 flagellar motor protein MotP; Reviewed; Region: PRK06926 655816008768 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 655816008769 catabolite control protein A; Region: ccpA; TIGR01481 655816008770 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816008771 DNA binding site [nucleotide binding] 655816008772 domain linker motif; other site 655816008773 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 655816008774 dimerization interface [polypeptide binding]; other site 655816008775 effector binding site; other site 655816008776 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 655816008777 chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801 655816008778 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 655816008779 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 655816008780 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 655816008781 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 655816008782 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 655816008783 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 655816008784 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655816008785 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655816008786 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 655816008787 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 655816008788 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 655816008789 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 655816008790 putative tRNA-binding site [nucleotide binding]; other site 655816008791 hypothetical protein; Provisional; Region: PRK13668 655816008792 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 655816008793 catalytic residues [active] 655816008794 YtoQ family protein; Region: YtoQ_fam; TIGR03646 655816008795 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 655816008796 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 655816008797 oligomer interface [polypeptide binding]; other site 655816008798 active site 655816008799 metal binding site [ion binding]; metal-binding site 655816008800 Predicted small secreted protein [Function unknown]; Region: COG5584 655816008801 malate dehydrogenase; Provisional; Region: PRK13529 655816008802 Malic enzyme, N-terminal domain; Region: malic; pfam00390 655816008803 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 655816008804 NAD(P) binding site [chemical binding]; other site 655816008805 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 655816008806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816008807 S-adenosylmethionine binding site [chemical binding]; other site 655816008808 YtzH-like protein; Region: YtzH; pfam14165 655816008809 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 655816008810 active site 655816008811 ATP binding site [chemical binding]; other site 655816008812 Phosphotransferase enzyme family; Region: APH; pfam01636 655816008813 substrate binding site [chemical binding]; other site 655816008814 pullulanase, type I; Region: pulA_typeI; TIGR02104 655816008815 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 655816008816 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 655816008817 Ca binding site [ion binding]; other site 655816008818 active site 655816008819 catalytic site [active] 655816008820 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 655816008821 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 655816008822 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 655816008823 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 655816008824 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 655816008825 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 655816008826 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 655816008827 dimer interface [polypeptide binding]; other site 655816008828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816008829 catalytic residue [active] 655816008830 dipeptidase PepV; Reviewed; Region: PRK07318 655816008831 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 655816008832 active site 655816008833 metal binding site [ion binding]; metal-binding site 655816008834 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 655816008835 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 655816008836 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 655816008837 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 655816008838 Walker A/P-loop; other site 655816008839 ATP binding site [chemical binding]; other site 655816008840 Q-loop/lid; other site 655816008841 ABC transporter signature motif; other site 655816008842 Walker B; other site 655816008843 D-loop; other site 655816008844 H-loop/switch region; other site 655816008845 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655816008846 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 655816008847 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 655816008848 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816008849 RNA binding surface [nucleotide binding]; other site 655816008850 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 655816008851 active site 655816008852 uracil binding [chemical binding]; other site 655816008853 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 655816008854 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 655816008855 Predicted flavoproteins [General function prediction only]; Region: COG2081 655816008856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655816008857 BCCT family transporter; Region: BCCT; pfam02028 655816008858 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 655816008859 Predicted integral membrane protein [Function unknown]; Region: COG5578 655816008860 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816008861 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655816008862 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 655816008863 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 655816008864 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 655816008865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816008866 dimer interface [polypeptide binding]; other site 655816008867 conserved gate region; other site 655816008868 ABC-ATPase subunit interface; other site 655816008869 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 655816008870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816008871 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816008872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816008873 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 655816008874 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655816008875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816008876 dimer interface [polypeptide binding]; other site 655816008877 conserved gate region; other site 655816008878 putative PBP binding loops; other site 655816008879 ABC-ATPase subunit interface; other site 655816008880 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 655816008881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008882 NAD(P) binding site [chemical binding]; other site 655816008883 active site 655816008884 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 655816008885 Cytochrome P450; Region: p450; cl12078 655816008886 biotin synthase; Validated; Region: PRK06256 655816008887 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816008888 FeS/SAM binding site; other site 655816008889 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 655816008890 AAA domain; Region: AAA_26; pfam13500 655816008891 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 655816008892 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 655816008893 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 655816008894 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 655816008895 substrate-cofactor binding pocket; other site 655816008896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816008897 catalytic residue [active] 655816008898 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 655816008899 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816008900 inhibitor-cofactor binding pocket; inhibition site 655816008901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816008902 catalytic residue [active] 655816008903 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 655816008904 Abhydrolase family; Region: Abhydrolase_7; pfam12715 655816008905 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816008906 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816008907 DNA binding site [nucleotide binding] 655816008908 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 655816008909 putative ligand binding site [chemical binding]; other site 655816008910 putative dimerization interface [polypeptide binding]; other site 655816008911 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 655816008912 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 655816008913 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 655816008914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816008915 dimer interface [polypeptide binding]; other site 655816008916 conserved gate region; other site 655816008917 putative PBP binding loops; other site 655816008918 ABC-ATPase subunit interface; other site 655816008919 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655816008920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816008921 dimer interface [polypeptide binding]; other site 655816008922 conserved gate region; other site 655816008923 putative PBP binding loops; other site 655816008924 ABC-ATPase subunit interface; other site 655816008925 alpha-galactosidase; Provisional; Region: PRK15076 655816008926 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 655816008927 NAD binding site [chemical binding]; other site 655816008928 sugar binding site [chemical binding]; other site 655816008929 divalent metal binding site [ion binding]; other site 655816008930 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816008931 dimer interface [polypeptide binding]; other site 655816008932 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 655816008933 active site residue [active] 655816008934 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 655816008935 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 655816008936 HIGH motif; other site 655816008937 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 655816008938 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 655816008939 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 655816008940 active site 655816008941 KMSKS motif; other site 655816008942 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 655816008943 tRNA binding surface [nucleotide binding]; other site 655816008944 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 655816008945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816008946 PAS domain; Region: PAS_9; pfam13426 655816008947 putative active site [active] 655816008948 heme pocket [chemical binding]; other site 655816008949 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816008950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816008951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816008952 putative substrate translocation pore; other site 655816008953 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 655816008954 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 655816008955 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 655816008956 FtsX-like permease family; Region: FtsX; pfam02687 655816008957 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816008958 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 655816008959 Walker A/P-loop; other site 655816008960 ATP binding site [chemical binding]; other site 655816008961 Q-loop/lid; other site 655816008962 ABC transporter signature motif; other site 655816008963 Walker B; other site 655816008964 D-loop; other site 655816008965 H-loop/switch region; other site 655816008966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816008967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816008968 ATP binding site [chemical binding]; other site 655816008969 Mg2+ binding site [ion binding]; other site 655816008970 G-X-G motif; other site 655816008971 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816008972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816008973 active site 655816008974 phosphorylation site [posttranslational modification] 655816008975 intermolecular recognition site; other site 655816008976 dimerization interface [polypeptide binding]; other site 655816008977 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816008978 DNA binding site [nucleotide binding] 655816008979 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 655816008980 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 655816008981 FtsX-like permease family; Region: FtsX; pfam02687 655816008982 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816008983 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 655816008984 Walker A/P-loop; other site 655816008985 ATP binding site [chemical binding]; other site 655816008986 Q-loop/lid; other site 655816008987 ABC transporter signature motif; other site 655816008988 Walker B; other site 655816008989 D-loop; other site 655816008990 H-loop/switch region; other site 655816008991 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 655816008992 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816008993 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 655816008994 Walker A/P-loop; other site 655816008995 ATP binding site [chemical binding]; other site 655816008996 Q-loop/lid; other site 655816008997 ABC transporter signature motif; other site 655816008998 Walker B; other site 655816008999 D-loop; other site 655816009000 H-loop/switch region; other site 655816009001 Predicted transcriptional regulators [Transcription]; Region: COG1725 655816009002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816009003 DNA-binding site [nucleotide binding]; DNA binding site 655816009004 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 655816009005 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 655816009006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 655816009007 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 655816009008 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 655816009009 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 655816009010 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 655816009011 PGAP1-like protein; Region: PGAP1; pfam07819 655816009012 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 655816009013 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 655816009014 trimer interface [polypeptide binding]; other site 655816009015 putative metal binding site [ion binding]; other site 655816009016 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 655816009017 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 655816009018 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 655816009019 active site 655816009020 dimer interface [polypeptide binding]; other site 655816009021 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 655816009022 Ligand Binding Site [chemical binding]; other site 655816009023 Molecular Tunnel; other site 655816009024 S-adenosylmethionine synthetase; Validated; Region: PRK05250 655816009025 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 655816009026 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 655816009027 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 655816009028 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 655816009029 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 655816009030 active site 655816009031 substrate-binding site [chemical binding]; other site 655816009032 metal-binding site [ion binding] 655816009033 ATP binding site [chemical binding]; other site 655816009034 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 655816009035 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 655816009036 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 655816009037 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 655816009038 NMT1-like family; Region: NMT1_2; pfam13379 655816009039 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 655816009040 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 655816009041 Walker A/P-loop; other site 655816009042 ATP binding site [chemical binding]; other site 655816009043 Q-loop/lid; other site 655816009044 ABC transporter signature motif; other site 655816009045 Walker B; other site 655816009046 D-loop; other site 655816009047 H-loop/switch region; other site 655816009048 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 655816009049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009050 dimer interface [polypeptide binding]; other site 655816009051 conserved gate region; other site 655816009052 putative PBP binding loops; other site 655816009053 ABC-ATPase subunit interface; other site 655816009054 Homeodomain-like domain; Region: HTH_23; pfam13384 655816009055 putative transposase OrfB; Reviewed; Region: PHA02517 655816009056 HTH-like domain; Region: HTH_21; pfam13276 655816009057 Integrase core domain; Region: rve; pfam00665 655816009058 Integrase core domain; Region: rve_3; pfam13683 655816009059 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 655816009060 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 655816009061 nudix motif; other site 655816009062 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 655816009063 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 655816009064 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 655816009065 dimerization interface [polypeptide binding]; other site 655816009066 DPS ferroxidase diiron center [ion binding]; other site 655816009067 ion pore; other site 655816009068 YtkA-like; Region: YtkA; pfam13115 655816009069 S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664 655816009070 Haemolytic domain; Region: Haemolytic; pfam01809 655816009071 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 655816009072 active site clefts [active] 655816009073 zinc binding site [ion binding]; other site 655816009074 dimer interface [polypeptide binding]; other site 655816009075 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 655816009076 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 655816009077 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 655816009078 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 655816009079 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 655816009080 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816009081 ABC-ATPase subunit interface; other site 655816009082 dimer interface [polypeptide binding]; other site 655816009083 putative PBP binding regions; other site 655816009084 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 655816009085 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816009086 ABC-ATPase subunit interface; other site 655816009087 dimer interface [polypeptide binding]; other site 655816009088 putative PBP binding regions; other site 655816009089 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 655816009090 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 655816009091 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 655816009092 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 655816009093 metal binding site [ion binding]; metal-binding site 655816009094 intersubunit interface [polypeptide binding]; other site 655816009095 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 655816009096 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 655816009097 active site 655816009098 octamer interface [polypeptide binding]; other site 655816009099 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 655816009100 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 655816009101 acyl-activating enzyme (AAE) consensus motif; other site 655816009102 putative AMP binding site [chemical binding]; other site 655816009103 putative active site [active] 655816009104 putative CoA binding site [chemical binding]; other site 655816009105 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816009106 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 655816009107 substrate binding site [chemical binding]; other site 655816009108 oxyanion hole (OAH) forming residues; other site 655816009109 trimer interface [polypeptide binding]; other site 655816009110 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 655816009111 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 655816009112 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 655816009113 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 655816009114 dimer interface [polypeptide binding]; other site 655816009115 tetramer interface [polypeptide binding]; other site 655816009116 PYR/PP interface [polypeptide binding]; other site 655816009117 TPP binding site [chemical binding]; other site 655816009118 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 655816009119 TPP-binding site; other site 655816009120 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 655816009121 chorismate binding enzyme; Region: Chorismate_bind; cl10555 655816009122 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 655816009123 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 655816009124 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 655816009125 active site 655816009126 tetramer interface; other site 655816009127 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 655816009128 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 655816009129 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 655816009130 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 655816009131 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 655816009132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816009133 NAD(P) binding site [chemical binding]; other site 655816009134 active site 655816009135 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816009136 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 655816009137 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 655816009138 spore coat protein YutH; Region: spore_yutH; TIGR02905 655816009139 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816009140 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 655816009141 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 655816009142 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 655816009143 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 655816009144 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 655816009145 homodimer interface [polypeptide binding]; other site 655816009146 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 655816009147 active site pocket [active] 655816009148 glycogen synthase; Provisional; Region: glgA; PRK00654 655816009149 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 655816009150 ADP-binding pocket [chemical binding]; other site 655816009151 homodimer interface [polypeptide binding]; other site 655816009152 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 655816009153 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 655816009154 ligand binding site; other site 655816009155 oligomer interface; other site 655816009156 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 655816009157 dimer interface [polypeptide binding]; other site 655816009158 N-terminal domain interface [polypeptide binding]; other site 655816009159 sulfate 1 binding site; other site 655816009160 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 655816009161 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 655816009162 ligand binding site; other site 655816009163 oligomer interface; other site 655816009164 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 655816009165 dimer interface [polypeptide binding]; other site 655816009166 N-terminal domain interface [polypeptide binding]; other site 655816009167 sulfate 1 binding site; other site 655816009168 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 655816009169 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 655816009170 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 655816009171 active site 655816009172 catalytic site [active] 655816009173 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 655816009174 Predicted membrane protein [Function unknown]; Region: COG3859 655816009175 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 655816009176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816009177 Coenzyme A binding pocket [chemical binding]; other site 655816009178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 655816009179 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 655816009180 DinB superfamily; Region: DinB_2; pfam12867 655816009181 metal-dependent hydrolase; Provisional; Region: PRK13291 655816009182 MOSC domain; Region: MOSC; pfam03473 655816009183 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 655816009184 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 655816009185 active site 655816009186 NAD binding site [chemical binding]; other site 655816009187 metal binding site [ion binding]; metal-binding site 655816009188 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 655816009189 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 655816009190 tetramerization interface [polypeptide binding]; other site 655816009191 NAD(P) binding site [chemical binding]; other site 655816009192 catalytic residues [active] 655816009193 Predicted transcriptional regulators [Transcription]; Region: COG1510 655816009194 MarR family; Region: MarR_2; pfam12802 655816009195 ydaO riboswitch leader; regulates the expression of the potassium uptake operon through a riboswitch mechanism; ligand is unknown; BSUW23_misc_RNA_52 655816009196 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 655816009197 TrkA-N domain; Region: TrkA_N; pfam02254 655816009198 TrkA-C domain; Region: TrkA_C; pfam02080 655816009199 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 655816009200 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 655816009201 Predicted membrane protein [Function unknown]; Region: COG4682 655816009202 yiaA/B two helix domain; Region: YiaAB; pfam05360 655816009203 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 655816009204 SH3-like domain; Region: SH3_8; pfam13457 655816009205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816009206 putative substrate translocation pore; other site 655816009207 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816009208 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 655816009209 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 655816009210 Domain of unknown function DUF20; Region: UPF0118; pfam01594 655816009211 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 655816009212 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816009213 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655816009214 L-rhamnose isomerase; Provisional; Region: PRK01076 655816009215 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 655816009216 Domain of unknown function (DUF718); Region: DUF718; cl01281 655816009217 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 655816009218 N- and C-terminal domain interface [polypeptide binding]; other site 655816009219 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 655816009220 active site 655816009221 putative catalytic site [active] 655816009222 metal binding site [ion binding]; metal-binding site 655816009223 ATP binding site [chemical binding]; other site 655816009224 carbohydrate binding site [chemical binding]; other site 655816009225 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655816009226 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 655816009227 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655816009228 short chain dehydrogenase; Validated; Region: PRK08324 655816009229 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 655816009230 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 655816009231 putative NAD(P) binding site [chemical binding]; other site 655816009232 active site 655816009233 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 655816009234 Cache domain; Region: Cache_1; pfam02743 655816009235 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816009236 dimerization interface [polypeptide binding]; other site 655816009237 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816009238 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816009239 dimer interface [polypeptide binding]; other site 655816009240 putative CheW interface [polypeptide binding]; other site 655816009241 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816009242 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 655816009243 Cache domain; Region: Cache_1; pfam02743 655816009244 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816009245 dimerization interface [polypeptide binding]; other site 655816009246 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816009247 dimer interface [polypeptide binding]; other site 655816009248 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 655816009249 putative CheW interface [polypeptide binding]; other site 655816009250 Tar ligand binding domain homologue; Region: TarH; pfam02203 655816009251 Cache domain; Region: Cache_1; pfam02743 655816009252 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816009253 dimerization interface [polypeptide binding]; other site 655816009254 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816009255 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816009256 dimer interface [polypeptide binding]; other site 655816009257 putative CheW interface [polypeptide binding]; other site 655816009258 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816009259 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 655816009260 Cache domain; Region: Cache_1; pfam02743 655816009261 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816009262 dimerization interface [polypeptide binding]; other site 655816009263 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816009264 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816009265 dimer interface [polypeptide binding]; other site 655816009266 putative CheW interface [polypeptide binding]; other site 655816009267 transglutaminase; Provisional; Region: tgl; PRK03187 655816009268 Nitronate monooxygenase; Region: NMO; pfam03060 655816009269 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 655816009270 FMN binding site [chemical binding]; other site 655816009271 substrate binding site [chemical binding]; other site 655816009272 putative catalytic residue [active] 655816009273 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 655816009274 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 655816009275 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 655816009276 Ca binding site [ion binding]; other site 655816009277 active site 655816009278 catalytic site [active] 655816009279 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 655816009280 Homeodomain-like domain; Region: HTH_23; pfam13384 655816009281 putative transposase OrfB; Reviewed; Region: PHA02517 655816009282 HTH-like domain; Region: HTH_21; pfam13276 655816009283 Integrase core domain; Region: rve; pfam00665 655816009284 Integrase core domain; Region: rve_3; pfam13683 655816009285 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 655816009286 Domain of unknown function DUF21; Region: DUF21; pfam01595 655816009287 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 655816009288 Transporter associated domain; Region: CorC_HlyC; smart01091 655816009289 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 655816009290 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 655816009291 Ion channel; Region: Ion_trans_2; pfam07885 655816009292 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 655816009293 TrkA-N domain; Region: TrkA_N; pfam02254 655816009294 YugN-like family; Region: YugN; pfam08868 655816009295 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 655816009296 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 655816009297 active site 655816009298 dimer interface [polypeptide binding]; other site 655816009299 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 655816009300 dimer interface [polypeptide binding]; other site 655816009301 active site 655816009302 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 655816009303 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 655816009304 dimer interface [polypeptide binding]; other site 655816009305 active site 655816009306 metal binding site [ion binding]; metal-binding site 655816009307 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 655816009308 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 655816009309 dimer interface [polypeptide binding]; other site 655816009310 active site 655816009311 metal binding site [ion binding]; metal-binding site 655816009312 Uncharacterized conserved protein [Function unknown]; Region: COG2155 655816009313 general stress protein 13; Validated; Region: PRK08059 655816009314 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 655816009315 RNA binding site [nucleotide binding]; other site 655816009316 hypothetical protein; Validated; Region: PRK07682 655816009317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816009318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816009319 homodimer interface [polypeptide binding]; other site 655816009320 catalytic residue [active] 655816009321 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 655816009322 AsnC family; Region: AsnC_trans_reg; pfam01037 655816009323 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 655816009324 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 655816009325 nucleophilic elbow; other site 655816009326 catalytic triad; other site 655816009327 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 655816009328 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 655816009329 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816009330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816009331 homodimer interface [polypeptide binding]; other site 655816009332 catalytic residue [active] 655816009333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816009334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816009335 dimer interface [polypeptide binding]; other site 655816009336 phosphorylation site [posttranslational modification] 655816009337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816009338 ATP binding site [chemical binding]; other site 655816009339 Mg2+ binding site [ion binding]; other site 655816009340 G-X-G motif; other site 655816009341 Kinase associated protein B; Region: KapB; pfam08810 655816009342 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 655816009343 active site 655816009344 catalytic site [active] 655816009345 substrate binding site [chemical binding]; other site 655816009346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816009347 putative substrate translocation pore; other site 655816009348 Transglycosylase; Region: Transgly; pfam00912 655816009349 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 655816009350 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 655816009351 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 655816009352 sensory histidine kinase DcuS; Provisional; Region: PRK11086 655816009353 PAS domain; Region: PAS; smart00091 655816009354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816009355 ATP binding site [chemical binding]; other site 655816009356 Mg2+ binding site [ion binding]; other site 655816009357 G-X-G motif; other site 655816009358 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 655816009359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816009360 active site 655816009361 phosphorylation site [posttranslational modification] 655816009362 intermolecular recognition site; other site 655816009363 dimerization interface [polypeptide binding]; other site 655816009364 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 655816009365 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 655816009366 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 655816009367 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 655816009368 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 655816009369 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 655816009370 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 655816009371 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 655816009372 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 655816009373 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 655816009374 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 655816009375 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 655816009376 CoenzymeA binding site [chemical binding]; other site 655816009377 subunit interaction site [polypeptide binding]; other site 655816009378 PHB binding site; other site 655816009379 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816009380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816009381 active site 655816009382 phosphorylation site [posttranslational modification] 655816009383 intermolecular recognition site; other site 655816009384 dimerization interface [polypeptide binding]; other site 655816009385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816009386 DNA binding residues [nucleotide binding] 655816009387 dimerization interface [polypeptide binding]; other site 655816009388 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 655816009389 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 655816009390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816009391 Histidine kinase; Region: HisKA_3; pfam07730 655816009392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816009393 ATP binding site [chemical binding]; other site 655816009394 Mg2+ binding site [ion binding]; other site 655816009395 G-X-G motif; other site 655816009396 Bacillus competence pheromone ComX; Region: ComX; pfam05952 655816009397 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 655816009398 substrate binding pocket [chemical binding]; other site 655816009399 substrate-Mg2+ binding site; other site 655816009400 aspartate-rich region 1; other site 655816009401 aspartate-rich region 2; other site 655816009402 DegQ (SacQ) family; Region: DegQ; pfam08181 655816009403 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 655816009404 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655816009405 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 655816009406 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 655816009407 active site 655816009408 Isochorismatase family; Region: Isochorismatase; pfam00857 655816009409 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 655816009410 catalytic triad [active] 655816009411 conserved cis-peptide bond; other site 655816009412 Uncharacterized conserved protein [Function unknown]; Region: COG5506 655816009413 YueH-like protein; Region: YueH; pfam14166 655816009414 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 655816009415 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 655816009416 Domain of unknown function DUF20; Region: UPF0118; pfam01594 655816009417 Uncharacterized conserved small protein [Function unknown]; Region: COG5428 655816009418 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 655816009419 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 655816009420 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816009421 Zn2+ binding site [ion binding]; other site 655816009422 Mg2+ binding site [ion binding]; other site 655816009423 short chain dehydrogenase; Provisional; Region: PRK06924 655816009424 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 655816009425 NADP binding site [chemical binding]; other site 655816009426 homodimer interface [polypeptide binding]; other site 655816009427 active site 655816009428 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 655816009429 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 655816009430 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 655816009431 Predicted membrane protein [Function unknown]; Region: COG1511 655816009432 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 655816009433 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 655816009434 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 655816009435 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 655816009436 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 655816009437 Domain of unknown function DUF87; Region: DUF87; pfam01935 655816009438 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 655816009439 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 655816009440 Uncharacterized small protein [Function unknown]; Region: COG5417 655816009441 Ubiquitin homologues; Region: UBQ; smart00213 655816009442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 655816009443 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 655816009444 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 655816009445 alanine dehydrogenase; Region: alaDH; TIGR00518 655816009446 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 655816009447 hexamer interface [polypeptide binding]; other site 655816009448 ligand binding site [chemical binding]; other site 655816009449 putative active site [active] 655816009450 NAD(P) binding site [chemical binding]; other site 655816009451 Uncharacterized conserved protein [Function unknown]; Region: COG5634 655816009452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 655816009453 Condensation domain; Region: Condensation; pfam00668 655816009454 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 655816009455 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 655816009456 acyl-activating enzyme (AAE) consensus motif; other site 655816009457 AMP binding site [chemical binding]; other site 655816009458 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816009459 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 655816009460 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816009461 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655816009462 acyl-activating enzyme (AAE) consensus motif; other site 655816009463 AMP binding site [chemical binding]; other site 655816009464 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655816009465 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 655816009466 hydrophobic substrate binding pocket; other site 655816009467 Isochorismatase family; Region: Isochorismatase; pfam00857 655816009468 active site 655816009469 conserved cis-peptide bond; other site 655816009470 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 655816009471 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 655816009472 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 655816009473 acyl-activating enzyme (AAE) consensus motif; other site 655816009474 active site 655816009475 AMP binding site [chemical binding]; other site 655816009476 substrate binding site [chemical binding]; other site 655816009477 isochorismate synthase DhbC; Validated; Region: PRK06923 655816009478 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 655816009479 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 655816009480 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 655816009481 putative NAD(P) binding site [chemical binding]; other site 655816009482 active site 655816009483 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 655816009484 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 655816009485 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 655816009486 Moco binding site; other site 655816009487 metal coordination site [ion binding]; other site 655816009488 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 655816009489 Predicted permease [General function prediction only]; Region: COG2056 655816009490 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 655816009491 AbgT putative transporter family; Region: ABG_transport; cl17431 655816009492 multifunctional aminopeptidase A; Provisional; Region: PRK00913 655816009493 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 655816009494 interface (dimer of trimers) [polypeptide binding]; other site 655816009495 Substrate-binding/catalytic site; other site 655816009496 Zn-binding sites [ion binding]; other site 655816009497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 655816009498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 655816009499 Putative membrane protein; Region: YuiB; pfam14068 655816009500 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 655816009501 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 655816009502 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816009503 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 655816009504 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655816009505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816009506 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 655816009507 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 655816009508 active site 655816009509 Integral membrane protein DUF95; Region: DUF95; cl00572 655816009510 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 655816009511 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 655816009512 Walker A/P-loop; other site 655816009513 ATP binding site [chemical binding]; other site 655816009514 Q-loop/lid; other site 655816009515 ABC transporter signature motif; other site 655816009516 Walker B; other site 655816009517 D-loop; other site 655816009518 H-loop/switch region; other site 655816009519 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 655816009520 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 655816009521 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816009522 Coenzyme A binding pocket [chemical binding]; other site 655816009523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 655816009524 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 655816009525 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 655816009526 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 655816009527 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 655816009528 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 655816009529 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 655816009530 Nucleoside recognition; Region: Gate; pfam07670 655816009531 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 655816009532 hypothetical protein; Provisional; Region: PRK13669 655816009533 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 655816009534 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816009535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 655816009536 NifU-like domain; Region: NifU; pfam01106 655816009537 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 655816009538 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 655816009539 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 655816009540 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 655816009541 homoserine kinase; Region: thrB; TIGR00191 655816009542 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 655816009543 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 655816009544 threonine synthase; Reviewed; Region: PRK06721 655816009545 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 655816009546 homodimer interface [polypeptide binding]; other site 655816009547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816009548 catalytic residue [active] 655816009549 homoserine dehydrogenase; Provisional; Region: PRK06349 655816009550 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 655816009551 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 655816009552 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 655816009553 spore coat protein YutH; Region: spore_yutH; TIGR02905 655816009554 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 655816009555 tetramer interfaces [polypeptide binding]; other site 655816009556 binuclear metal-binding site [ion binding]; other site 655816009557 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 655816009558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816009559 active site 655816009560 motif I; other site 655816009561 motif II; other site 655816009562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816009563 Uncharacterized conserved protein [Function unknown]; Region: COG2445 655816009564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 655816009565 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 655816009566 lipoyl synthase; Provisional; Region: PRK05481 655816009567 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816009568 FeS/SAM binding site; other site 655816009569 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 655816009570 Peptidase family M23; Region: Peptidase_M23; pfam01551 655816009571 sporulation protein YunB; Region: spo_yunB; TIGR02832 655816009572 Uncharacterized conserved protein [Function unknown]; Region: COG3377 655816009573 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 655816009574 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 655816009575 active site 655816009576 metal binding site [ion binding]; metal-binding site 655816009577 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 655816009578 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 655816009579 Uncharacterized conserved protein [Function unknown]; Region: COG1801 655816009580 allantoinase; Provisional; Region: PRK06189 655816009581 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 655816009582 active site 655816009583 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 655816009584 DRTGG domain; Region: DRTGG; pfam07085 655816009585 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 655816009586 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 655816009587 xanthine permease; Region: pbuX; TIGR03173 655816009588 xanthine permease; Region: pbuX; TIGR03173 655816009589 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 655816009590 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 655816009591 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 655816009592 active site 655816009593 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 655816009594 active site 655816009595 homotetramer interface [polypeptide binding]; other site 655816009596 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 655816009597 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 655816009598 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 655816009599 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 655816009600 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 655816009601 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 655816009602 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 655816009603 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 655816009604 Ligand binding site; other site 655816009605 metal-binding site 655816009606 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 655816009607 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 655816009608 XdhC Rossmann domain; Region: XdhC_C; pfam13478 655816009609 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 655816009610 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816009611 catalytic residue [active] 655816009612 allantoate amidohydrolase; Reviewed; Region: PRK09290 655816009613 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 655816009614 active site 655816009615 metal binding site [ion binding]; metal-binding site 655816009616 dimer interface [polypeptide binding]; other site 655816009617 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 655816009618 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 655816009619 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 655816009620 Walker A/P-loop; other site 655816009621 ATP binding site [chemical binding]; other site 655816009622 Q-loop/lid; other site 655816009623 ABC transporter signature motif; other site 655816009624 Walker B; other site 655816009625 D-loop; other site 655816009626 H-loop/switch region; other site 655816009627 TOBE domain; Region: TOBE_2; pfam08402 655816009628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816009629 DNA-binding site [nucleotide binding]; DNA binding site 655816009630 UTRA domain; Region: UTRA; pfam07702 655816009631 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655816009632 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 655816009633 substrate binding site [chemical binding]; other site 655816009634 ATP binding site [chemical binding]; other site 655816009635 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655816009636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009637 dimer interface [polypeptide binding]; other site 655816009638 conserved gate region; other site 655816009639 putative PBP binding loops; other site 655816009640 ABC-ATPase subunit interface; other site 655816009641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009642 dimer interface [polypeptide binding]; other site 655816009643 conserved gate region; other site 655816009644 putative PBP binding loops; other site 655816009645 ABC-ATPase subunit interface; other site 655816009646 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 655816009647 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 655816009648 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 655816009649 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 655816009650 putative active site [active] 655816009651 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 655816009652 dimer interface [polypeptide binding]; other site 655816009653 active site 655816009654 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 655816009655 GIY-YIG motif/motif A; other site 655816009656 active site 655816009657 catalytic site [active] 655816009658 putative DNA binding site [nucleotide binding]; other site 655816009659 metal binding site [ion binding]; metal-binding site 655816009660 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 655816009661 hydroxyglutarate oxidase; Provisional; Region: PRK11728 655816009662 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816009663 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 655816009664 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816009665 dimerization interface [polypeptide binding]; other site 655816009666 putative DNA binding site [nucleotide binding]; other site 655816009667 putative Zn2+ binding site [ion binding]; other site 655816009668 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 655816009669 FeS assembly protein SufB; Region: sufB; TIGR01980 655816009670 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 655816009671 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 655816009672 trimerization site [polypeptide binding]; other site 655816009673 active site 655816009674 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 655816009675 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 655816009676 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816009677 catalytic residue [active] 655816009678 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 655816009679 FeS assembly protein SufD; Region: sufD; TIGR01981 655816009680 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 655816009681 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 655816009682 Walker A/P-loop; other site 655816009683 ATP binding site [chemical binding]; other site 655816009684 Q-loop/lid; other site 655816009685 ABC transporter signature motif; other site 655816009686 Walker B; other site 655816009687 D-loop; other site 655816009688 H-loop/switch region; other site 655816009689 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 655816009690 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 655816009691 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 655816009692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009693 conserved gate region; other site 655816009694 ABC-ATPase subunit interface; other site 655816009695 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 655816009696 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 655816009697 Walker A/P-loop; other site 655816009698 ATP binding site [chemical binding]; other site 655816009699 Q-loop/lid; other site 655816009700 ABC transporter signature motif; other site 655816009701 Walker B; other site 655816009702 D-loop; other site 655816009703 H-loop/switch region; other site 655816009704 NIL domain; Region: NIL; pfam09383 655816009705 SCP-2 sterol transfer family; Region: SCP2; pfam02036 655816009706 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 655816009707 catalytic residues [active] 655816009708 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 655816009709 putative active site [active] 655816009710 putative metal binding site [ion binding]; other site 655816009711 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 655816009712 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 655816009713 lipoyl attachment site [posttranslational modification]; other site 655816009714 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 655816009715 ArsC family; Region: ArsC; pfam03960 655816009716 putative ArsC-like catalytic residues; other site 655816009717 putative TRX-like catalytic residues [active] 655816009718 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 655816009719 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 655816009720 active site 655816009721 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 655816009722 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 655816009723 dimer interface [polypeptide binding]; other site 655816009724 active site 655816009725 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 655816009726 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 655816009727 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 655816009728 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 655816009729 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 655816009730 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816009731 substrate binding site [chemical binding]; other site 655816009732 oxyanion hole (OAH) forming residues; other site 655816009733 trimer interface [polypeptide binding]; other site 655816009734 YuzL-like protein; Region: YuzL; pfam14115 655816009735 Proline dehydrogenase; Region: Pro_dh; pfam01619 655816009736 Coat F domain; Region: Coat_F; pfam07875 655816009737 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816009738 MarR family; Region: MarR; pfam01047 655816009739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816009740 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816009741 putative substrate translocation pore; other site 655816009742 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 655816009743 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 655816009744 classical (c) SDRs; Region: SDR_c; cd05233 655816009745 NAD(P) binding site [chemical binding]; other site 655816009746 active site 655816009747 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816009748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816009749 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 655816009750 putative dimerization interface [polypeptide binding]; other site 655816009751 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 655816009752 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655816009753 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655816009754 Walker A/P-loop; other site 655816009755 ATP binding site [chemical binding]; other site 655816009756 Q-loop/lid; other site 655816009757 ABC transporter signature motif; other site 655816009758 Walker B; other site 655816009759 D-loop; other site 655816009760 H-loop/switch region; other site 655816009761 YusW-like protein; Region: YusW; pfam14039 655816009762 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 655816009763 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 655816009764 active site 655816009765 Zn binding site [ion binding]; other site 655816009766 short chain dehydrogenase; Provisional; Region: PRK06914 655816009767 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 655816009768 NADP binding site [chemical binding]; other site 655816009769 active site 655816009770 steroid binding site; other site 655816009771 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 655816009772 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 655816009773 dimerization interface [polypeptide binding]; other site 655816009774 DPS ferroxidase diiron center [ion binding]; other site 655816009775 ion pore; other site 655816009776 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 655816009777 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 655816009778 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655816009779 protein binding site [polypeptide binding]; other site 655816009780 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816009781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816009782 active site 655816009783 phosphorylation site [posttranslational modification] 655816009784 intermolecular recognition site; other site 655816009785 dimerization interface [polypeptide binding]; other site 655816009786 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816009787 DNA binding site [nucleotide binding] 655816009788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816009789 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816009790 dimerization interface [polypeptide binding]; other site 655816009791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816009792 dimer interface [polypeptide binding]; other site 655816009793 phosphorylation site [posttranslational modification] 655816009794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816009795 ATP binding site [chemical binding]; other site 655816009796 Mg2+ binding site [ion binding]; other site 655816009797 G-X-G motif; other site 655816009798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816009799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816009800 fumarate hydratase; Reviewed; Region: fumC; PRK00485 655816009801 Class II fumarases; Region: Fumarase_classII; cd01362 655816009802 active site 655816009803 tetramer interface [polypeptide binding]; other site 655816009804 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 655816009805 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 655816009806 Spore germination protein; Region: Spore_permease; pfam03845 655816009807 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 655816009808 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 655816009809 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816009810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816009811 active site 655816009812 phosphorylation site [posttranslational modification] 655816009813 intermolecular recognition site; other site 655816009814 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816009815 DNA binding residues [nucleotide binding] 655816009816 dimerization interface [polypeptide binding]; other site 655816009817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816009818 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816009819 dimerization interface [polypeptide binding]; other site 655816009820 Histidine kinase; Region: HisKA_3; pfam07730 655816009821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816009822 ATP binding site [chemical binding]; other site 655816009823 Mg2+ binding site [ion binding]; other site 655816009824 G-X-G motif; other site 655816009825 Predicted membrane protein [Function unknown]; Region: COG4758 655816009826 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 655816009827 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 655816009828 Uncharacterized conserved protein [Function unknown]; Region: COG3595 655816009829 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 655816009830 PspA/IM30 family; Region: PspA_IM30; pfam04012 655816009831 H+ Antiporter protein; Region: 2A0121; TIGR00900 655816009832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816009833 putative substrate translocation pore; other site 655816009834 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 655816009835 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655816009836 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655816009837 Walker A/P-loop; other site 655816009838 ATP binding site [chemical binding]; other site 655816009839 Q-loop/lid; other site 655816009840 ABC transporter signature motif; other site 655816009841 Walker B; other site 655816009842 D-loop; other site 655816009843 H-loop/switch region; other site 655816009844 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 655816009845 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 655816009846 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816009847 ABC-ATPase subunit interface; other site 655816009848 dimer interface [polypeptide binding]; other site 655816009849 putative PBP binding regions; other site 655816009850 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 655816009851 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 655816009852 putative binding site residues; other site 655816009853 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 655816009854 classical (c) SDRs; Region: SDR_c; cd05233 655816009855 NAD(P) binding site [chemical binding]; other site 655816009856 active site 655816009857 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 655816009858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816009859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816009860 dimer interface [polypeptide binding]; other site 655816009861 phosphorylation site [posttranslational modification] 655816009862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816009863 ATP binding site [chemical binding]; other site 655816009864 Mg2+ binding site [ion binding]; other site 655816009865 G-X-G motif; other site 655816009866 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816009867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816009868 active site 655816009869 phosphorylation site [posttranslational modification] 655816009870 intermolecular recognition site; other site 655816009871 dimerization interface [polypeptide binding]; other site 655816009872 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816009873 DNA binding site [nucleotide binding] 655816009874 hypothetical protein; Provisional; Region: PRK14082 655816009875 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 655816009876 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816009877 DNA binding residues [nucleotide binding] 655816009878 YvrJ protein family; Region: YvrJ; pfam12841 655816009879 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 655816009880 Cupin; Region: Cupin_1; smart00835 655816009881 Cupin; Region: Cupin_1; smart00835 655816009882 Regulatory protein YrvL; Region: YrvL; pfam14184 655816009883 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 655816009884 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 655816009885 FtsX-like permease family; Region: FtsX; pfam02687 655816009886 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816009887 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 655816009888 Walker A/P-loop; other site 655816009889 ATP binding site [chemical binding]; other site 655816009890 Q-loop/lid; other site 655816009891 ABC transporter signature motif; other site 655816009892 Walker B; other site 655816009893 D-loop; other site 655816009894 H-loop/switch region; other site 655816009895 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 655816009896 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655816009897 HlyD family secretion protein; Region: HlyD_3; pfam13437 655816009898 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655816009899 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655816009900 Walker A/P-loop; other site 655816009901 ATP binding site [chemical binding]; other site 655816009902 Q-loop/lid; other site 655816009903 ABC transporter signature motif; other site 655816009904 Walker B; other site 655816009905 D-loop; other site 655816009906 H-loop/switch region; other site 655816009907 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655816009908 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816009909 ABC-ATPase subunit interface; other site 655816009910 dimer interface [polypeptide binding]; other site 655816009911 putative PBP binding regions; other site 655816009912 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655816009913 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816009914 ABC-ATPase subunit interface; other site 655816009915 dimer interface [polypeptide binding]; other site 655816009916 putative PBP binding regions; other site 655816009917 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 655816009918 putative ligand binding residues [chemical binding]; other site 655816009919 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 655816009920 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 655816009921 Spore germination protein; Region: Spore_permease; cl17796 655816009922 small, acid-soluble spore protein, SspJ family; Region: spore_sspJ; TIGR02863 655816009923 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 655816009924 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 655816009925 Sulfatase; Region: Sulfatase; pfam00884 655816009926 DNA binding domain, excisionase family; Region: excise; TIGR01764 655816009927 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 655816009928 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 655816009929 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 655816009930 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 655816009931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009932 dimer interface [polypeptide binding]; other site 655816009933 conserved gate region; other site 655816009934 putative PBP binding loops; other site 655816009935 ABC-ATPase subunit interface; other site 655816009936 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816009937 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655816009938 active site 655816009939 catalytic tetrad [active] 655816009940 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 655816009941 sulfite reductase subunit beta; Provisional; Region: PRK13504 655816009942 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 655816009943 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 655816009944 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 655816009945 Flavodoxin; Region: Flavodoxin_1; pfam00258 655816009946 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 655816009947 FAD binding pocket [chemical binding]; other site 655816009948 FAD binding motif [chemical binding]; other site 655816009949 catalytic residues [active] 655816009950 NAD binding pocket [chemical binding]; other site 655816009951 phosphate binding motif [ion binding]; other site 655816009952 beta-alpha-beta structure motif; other site 655816009953 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 655816009954 Part of AAA domain; Region: AAA_19; pfam13245 655816009955 Family description; Region: UvrD_C_2; pfam13538 655816009956 Predicted membrane protein [Function unknown]; Region: COG2860 655816009957 UPF0126 domain; Region: UPF0126; pfam03458 655816009958 UPF0126 domain; Region: UPF0126; pfam03458 655816009959 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 655816009960 Thioredoxin; Region: Thioredoxin_4; pfam13462 655816009961 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 655816009962 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 655816009963 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 655816009964 metal-binding site [ion binding] 655816009965 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 655816009966 Soluble P-type ATPase [General function prediction only]; Region: COG4087 655816009967 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 655816009968 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 655816009969 metal-binding site [ion binding] 655816009970 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 655816009971 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 655816009972 metal-binding site [ion binding] 655816009973 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 655816009974 Soluble P-type ATPase [General function prediction only]; Region: COG4087 655816009975 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 655816009976 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 655816009977 metal-binding site [ion binding] 655816009978 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 655816009979 putative homodimer interface [polypeptide binding]; other site 655816009980 putative homotetramer interface [polypeptide binding]; other site 655816009981 allosteric switch controlling residues; other site 655816009982 putative metal binding site [ion binding]; other site 655816009983 putative homodimer-homodimer interface [polypeptide binding]; other site 655816009984 putative oxidoreductase; Provisional; Region: PRK11579 655816009985 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655816009986 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 655816009987 azoreductase; Reviewed; Region: PRK00170 655816009988 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 655816009989 Predicted membrane protein [Function unknown]; Region: COG1289 655816009990 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 655816009991 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 655816009992 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 655816009993 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816009994 DNA-binding site [nucleotide binding]; DNA binding site 655816009995 FCD domain; Region: FCD; pfam07729 655816009996 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 655816009997 EamA-like transporter family; Region: EamA; pfam00892 655816009998 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 655816009999 classical (c) SDRs; Region: SDR_c; cd05233 655816010000 NAD(P) binding site [chemical binding]; other site 655816010001 active site 655816010002 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 655816010003 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 655816010004 SmpB-tmRNA interface; other site 655816010005 ribonuclease R; Region: RNase_R; TIGR02063 655816010006 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 655816010007 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 655816010008 RNB domain; Region: RNB; pfam00773 655816010009 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 655816010010 RNA binding site [nucleotide binding]; other site 655816010011 Esterase/lipase [General function prediction only]; Region: COG1647 655816010012 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 655816010013 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 655816010014 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 655816010015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816010016 salt bridge; other site 655816010017 non-specific DNA binding site [nucleotide binding]; other site 655816010018 sequence-specific DNA binding site [nucleotide binding]; other site 655816010019 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 655816010020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816010021 non-specific DNA binding site [nucleotide binding]; other site 655816010022 salt bridge; other site 655816010023 sequence-specific DNA binding site [nucleotide binding]; other site 655816010024 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 655816010025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816010026 non-specific DNA binding site [nucleotide binding]; other site 655816010027 salt bridge; other site 655816010028 sequence-specific DNA binding site [nucleotide binding]; other site 655816010029 Predicted transcriptional regulators [Transcription]; Region: COG1733 655816010030 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 655816010031 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816010032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816010033 dimer interface [polypeptide binding]; other site 655816010034 phosphorylation site [posttranslational modification] 655816010035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816010036 ATP binding site [chemical binding]; other site 655816010037 Mg2+ binding site [ion binding]; other site 655816010038 G-X-G motif; other site 655816010039 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816010040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816010041 active site 655816010042 phosphorylation site [posttranslational modification] 655816010043 intermolecular recognition site; other site 655816010044 dimerization interface [polypeptide binding]; other site 655816010045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816010046 DNA binding site [nucleotide binding] 655816010047 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 655816010048 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 655816010049 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 655816010050 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 655816010051 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 655816010052 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 655816010053 Walker A/P-loop; other site 655816010054 ATP binding site [chemical binding]; other site 655816010055 Q-loop/lid; other site 655816010056 ABC transporter signature motif; other site 655816010057 Walker B; other site 655816010058 D-loop; other site 655816010059 H-loop/switch region; other site 655816010060 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 655816010061 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 655816010062 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 655816010063 active site 655816010064 zinc binding site [ion binding]; other site 655816010065 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816010066 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 655816010067 Walker A/P-loop; other site 655816010068 ATP binding site [chemical binding]; other site 655816010069 Q-loop/lid; other site 655816010070 ABC transporter signature motif; other site 655816010071 Walker B; other site 655816010072 D-loop; other site 655816010073 H-loop/switch region; other site 655816010074 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 655816010075 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 655816010076 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 655816010077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816010078 dimer interface [polypeptide binding]; other site 655816010079 conserved gate region; other site 655816010080 putative PBP binding loops; other site 655816010081 ABC-ATPase subunit interface; other site 655816010082 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 655816010083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816010084 dimer interface [polypeptide binding]; other site 655816010085 conserved gate region; other site 655816010086 putative PBP binding loops; other site 655816010087 ABC-ATPase subunit interface; other site 655816010088 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 655816010089 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 655816010090 Walker A/P-loop; other site 655816010091 ATP binding site [chemical binding]; other site 655816010092 Q-loop/lid; other site 655816010093 ABC transporter signature motif; other site 655816010094 Walker B; other site 655816010095 D-loop; other site 655816010096 H-loop/switch region; other site 655816010097 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 655816010098 Predicted transcriptional regulators [Transcription]; Region: COG1510 655816010099 MarR family; Region: MarR_2; pfam12802 655816010100 Dopey, N-terminal; Region: Dopey_N; cl04407 655816010101 Homeodomain-like domain; Region: HTH_23; pfam13384 655816010102 putative transposase OrfB; Reviewed; Region: PHA02517 655816010103 HTH-like domain; Region: HTH_21; pfam13276 655816010104 Integrase core domain; Region: rve; pfam00665 655816010105 Integrase core domain; Region: rve_3; cl15866 655816010106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816010107 dimer interface [polypeptide binding]; other site 655816010108 conserved gate region; other site 655816010109 putative PBP binding loops; other site 655816010110 ABC-ATPase subunit interface; other site 655816010111 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 655816010112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816010113 dimer interface [polypeptide binding]; other site 655816010114 conserved gate region; other site 655816010115 putative PBP binding loops; other site 655816010116 ABC-ATPase subunit interface; other site 655816010117 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 655816010118 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 655816010119 Walker A/P-loop; other site 655816010120 ATP binding site [chemical binding]; other site 655816010121 Q-loop/lid; other site 655816010122 ABC transporter signature motif; other site 655816010123 Walker B; other site 655816010124 D-loop; other site 655816010125 H-loop/switch region; other site 655816010126 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 655816010127 Predicted transcriptional regulators [Transcription]; Region: COG1510 655816010128 MarR family; Region: MarR_2; pfam12802 655816010129 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 655816010130 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 655816010131 Double zinc ribbon; Region: DZR; pfam12773 655816010132 Predicted membrane protein [Function unknown]; Region: COG4640 655816010133 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 655816010134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816010135 Coenzyme A binding pocket [chemical binding]; other site 655816010136 enolase; Provisional; Region: eno; PRK00077 655816010137 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 655816010138 dimer interface [polypeptide binding]; other site 655816010139 metal binding site [ion binding]; metal-binding site 655816010140 substrate binding pocket [chemical binding]; other site 655816010141 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 655816010142 phosphoglyceromutase; Provisional; Region: PRK05434 655816010143 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 655816010144 triosephosphate isomerase; Provisional; Region: PRK14565 655816010145 substrate binding site [chemical binding]; other site 655816010146 dimer interface [polypeptide binding]; other site 655816010147 catalytic triad [active] 655816010148 Phosphoglycerate kinase; Region: PGK; pfam00162 655816010149 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 655816010150 substrate binding site [chemical binding]; other site 655816010151 hinge regions; other site 655816010152 ADP binding site [chemical binding]; other site 655816010153 catalytic site [active] 655816010154 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 655816010155 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 655816010156 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 655816010157 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 655816010158 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 655816010159 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 655816010160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010161 putative substrate translocation pore; other site 655816010162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010163 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816010164 DNA-binding site [nucleotide binding]; DNA binding site 655816010165 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816010166 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 655816010167 putative dimerization interface [polypeptide binding]; other site 655816010168 putative ligand binding site [chemical binding]; other site 655816010169 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 655816010170 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 655816010171 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 655816010172 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 655816010173 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 655816010174 active site 655816010175 Uncharacterized conserved protein [Function unknown]; Region: COG1556 655816010176 iron-sulfur cluster-binding protein; Region: TIGR00273 655816010177 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 655816010178 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 655816010179 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 655816010180 Cysteine-rich domain; Region: CCG; pfam02754 655816010181 Cysteine-rich domain; Region: CCG; pfam02754 655816010182 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 655816010183 Predicted transcriptional regulators [Transcription]; Region: COG1695 655816010184 Transcriptional regulator PadR-like family; Region: PadR; cl17335 655816010185 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816010186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816010187 active site 655816010188 phosphorylation site [posttranslational modification] 655816010189 intermolecular recognition site; other site 655816010190 dimerization interface [polypeptide binding]; other site 655816010191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816010192 DNA binding residues [nucleotide binding] 655816010193 dimerization interface [polypeptide binding]; other site 655816010194 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816010195 Histidine kinase; Region: HisKA_3; pfam07730 655816010196 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 655816010197 ATP binding site [chemical binding]; other site 655816010198 Mg2+ binding site [ion binding]; other site 655816010199 G-X-G motif; other site 655816010200 ABC-2 type transporter; Region: ABC2_membrane; cl17235 655816010201 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 655816010202 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816010203 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 655816010204 Walker A/P-loop; other site 655816010205 ATP binding site [chemical binding]; other site 655816010206 Q-loop/lid; other site 655816010207 ABC transporter signature motif; other site 655816010208 Walker B; other site 655816010209 D-loop; other site 655816010210 H-loop/switch region; other site 655816010211 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816010212 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 655816010213 catalytic site [active] 655816010214 PAS domain S-box; Region: sensory_box; TIGR00229 655816010215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816010216 putative active site [active] 655816010217 heme pocket [chemical binding]; other site 655816010218 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 655816010219 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 655816010220 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 655816010221 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 655816010222 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 655816010223 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 655816010224 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 655816010225 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 655816010226 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655816010227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816010228 dimer interface [polypeptide binding]; other site 655816010229 conserved gate region; other site 655816010230 putative PBP binding loops; other site 655816010231 ABC-ATPase subunit interface; other site 655816010232 TM2 domain; Region: TM2; pfam05154 655816010233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816010234 dimer interface [polypeptide binding]; other site 655816010235 conserved gate region; other site 655816010236 ABC-ATPase subunit interface; other site 655816010237 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 655816010238 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 655816010239 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816010240 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816010241 DNA binding site [nucleotide binding] 655816010242 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 655816010243 putative dimerization interface [polypeptide binding]; other site 655816010244 putative ligand binding site [chemical binding]; other site 655816010245 Transcriptional regulators [Transcription]; Region: FadR; COG2186 655816010246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816010247 DNA-binding site [nucleotide binding]; DNA binding site 655816010248 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 655816010249 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 655816010250 L-lactate permease; Region: Lactate_perm; pfam02652 655816010251 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 655816010252 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 655816010253 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 655816010254 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 655816010255 YvfG protein; Region: YvfG; pfam09628 655816010256 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 655816010257 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 655816010258 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 655816010259 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 655816010260 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 655816010261 inhibitor-cofactor binding pocket; inhibition site 655816010262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816010263 catalytic residue [active] 655816010264 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 655816010265 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 655816010266 putative trimer interface [polypeptide binding]; other site 655816010267 putative CoA binding site [chemical binding]; other site 655816010268 Bacterial sugar transferase; Region: Bac_transf; pfam02397 655816010269 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 655816010270 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 655816010271 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010272 active site 655816010273 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 655816010274 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 655816010275 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010276 active site 655816010277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816010278 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 655816010279 putative ADP-binding pocket [chemical binding]; other site 655816010280 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 655816010281 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 655816010282 active site 655816010283 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 655816010284 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816010285 putative ADP-binding pocket [chemical binding]; other site 655816010286 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 655816010287 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 655816010288 NAD(P) binding site [chemical binding]; other site 655816010289 homodimer interface [polypeptide binding]; other site 655816010290 substrate binding site [chemical binding]; other site 655816010291 active site 655816010292 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 655816010293 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 655816010294 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 655816010295 Chain length determinant protein; Region: Wzz; cl15801 655816010296 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 655816010297 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816010298 non-specific DNA binding site [nucleotide binding]; other site 655816010299 salt bridge; other site 655816010300 sequence-specific DNA binding site [nucleotide binding]; other site 655816010301 Anti-repressor SinI; Region: SinI; pfam08671 655816010302 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 655816010303 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 655816010304 substrate binding pocket [chemical binding]; other site 655816010305 catalytic triad [active] 655816010306 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 655816010307 hypothetical protein; Provisional; Region: PRK00872 655816010308 aspartate racemase; Region: asp_race; TIGR00035 655816010309 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 655816010310 Beta-lactamase; Region: Beta-lactamase; pfam00144 655816010311 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 655816010312 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 655816010313 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 655816010314 active site 655816010315 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 655816010316 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 655816010317 substrate binding [chemical binding]; other site 655816010318 active site 655816010319 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 655816010320 amino acid transporter; Region: 2A0306; TIGR00909 655816010321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816010322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816010323 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 655816010324 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 655816010325 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 655816010326 Clp protease; Region: CLP_protease; pfam00574 655816010327 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 655816010328 oligomer interface [polypeptide binding]; other site 655816010329 active site residues [active] 655816010330 TIGR00730 family protein; Region: TIGR00730 655816010331 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 655816010332 metal binding site [ion binding]; metal-binding site 655816010333 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 655816010334 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 655816010335 Sulfate transporter family; Region: Sulfate_transp; pfam00916 655816010336 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 655816010337 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 655816010338 active site clefts [active] 655816010339 zinc binding site [ion binding]; other site 655816010340 dimer interface [polypeptide binding]; other site 655816010341 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 655816010342 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 655816010343 dimerization interface [polypeptide binding]; other site 655816010344 ligand binding site [chemical binding]; other site 655816010345 NADP binding site [chemical binding]; other site 655816010346 catalytic site [active] 655816010347 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 655816010348 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816010349 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 655816010350 Walker A/P-loop; other site 655816010351 ATP binding site [chemical binding]; other site 655816010352 Q-loop/lid; other site 655816010353 ABC transporter signature motif; other site 655816010354 Walker B; other site 655816010355 D-loop; other site 655816010356 H-loop/switch region; other site 655816010357 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816010358 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 655816010359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816010360 ATP binding site [chemical binding]; other site 655816010361 Mg2+ binding site [ion binding]; other site 655816010362 G-X-G motif; other site 655816010363 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816010364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816010365 active site 655816010366 phosphorylation site [posttranslational modification] 655816010367 intermolecular recognition site; other site 655816010368 dimerization interface [polypeptide binding]; other site 655816010369 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816010370 DNA binding site [nucleotide binding] 655816010371 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 655816010372 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 655816010373 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 655816010374 dimerization domain swap beta strand [polypeptide binding]; other site 655816010375 regulatory protein interface [polypeptide binding]; other site 655816010376 active site 655816010377 regulatory phosphorylation site [posttranslational modification]; other site 655816010378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 655816010379 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 655816010380 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 655816010381 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 655816010382 phosphate binding site [ion binding]; other site 655816010383 putative substrate binding pocket [chemical binding]; other site 655816010384 dimer interface [polypeptide binding]; other site 655816010385 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 655816010386 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 655816010387 putative active site [active] 655816010388 nucleotide binding site [chemical binding]; other site 655816010389 nudix motif; other site 655816010390 putative metal binding site [ion binding]; other site 655816010391 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 655816010392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655816010393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816010394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 655816010395 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 655816010396 NlpC/P60 family; Region: NLPC_P60; pfam00877 655816010397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816010398 binding surface 655816010399 TPR motif; other site 655816010400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816010401 TPR motif; other site 655816010402 binding surface 655816010403 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816010404 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655816010405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655816010406 Walker A/P-loop; other site 655816010407 ATP binding site [chemical binding]; other site 655816010408 Q-loop/lid; other site 655816010409 ABC transporter signature motif; other site 655816010410 Walker B; other site 655816010411 D-loop; other site 655816010412 H-loop/switch region; other site 655816010413 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 655816010414 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 655816010415 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 655816010416 metal binding site [ion binding]; metal-binding site 655816010417 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 655816010418 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 655816010419 substrate binding site [chemical binding]; other site 655816010420 glutamase interaction surface [polypeptide binding]; other site 655816010421 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 655816010422 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 655816010423 catalytic residues [active] 655816010424 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 655816010425 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 655816010426 putative active site [active] 655816010427 oxyanion strand; other site 655816010428 catalytic triad [active] 655816010429 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 655816010430 putative active site pocket [active] 655816010431 4-fold oligomerization interface [polypeptide binding]; other site 655816010432 metal binding residues [ion binding]; metal-binding site 655816010433 3-fold/trimer interface [polypeptide binding]; other site 655816010434 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 655816010435 histidinol dehydrogenase; Region: hisD; TIGR00069 655816010436 NAD binding site [chemical binding]; other site 655816010437 dimerization interface [polypeptide binding]; other site 655816010438 product binding site; other site 655816010439 substrate binding site [chemical binding]; other site 655816010440 zinc binding site [ion binding]; other site 655816010441 catalytic residues [active] 655816010442 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 655816010443 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 655816010444 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 655816010445 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 655816010446 dimer interface [polypeptide binding]; other site 655816010447 motif 1; other site 655816010448 active site 655816010449 motif 2; other site 655816010450 motif 3; other site 655816010451 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 655816010452 putative active site [active] 655816010453 Pectate lyase; Region: Pectate_lyase; pfam03211 655816010454 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 655816010455 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 655816010456 CoA binding site [chemical binding]; other site 655816010457 active site 655816010458 pyrophosphatase PpaX; Provisional; Region: PRK13288 655816010459 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816010460 motif II; other site 655816010461 Nucleoside recognition; Region: Gate; pfam07670 655816010462 Nucleoside recognition; Region: Gate; pfam07670 655816010463 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 655816010464 HPr kinase/phosphorylase; Provisional; Region: PRK05428 655816010465 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 655816010466 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 655816010467 Hpr binding site; other site 655816010468 active site 655816010469 homohexamer subunit interaction site [polypeptide binding]; other site 655816010470 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 655816010471 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 655816010472 active site 655816010473 dimer interface [polypeptide binding]; other site 655816010474 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 655816010475 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 655816010476 active site 655816010477 trimer interface [polypeptide binding]; other site 655816010478 allosteric site; other site 655816010479 active site lid [active] 655816010480 hexamer (dimer of trimers) interface [polypeptide binding]; other site 655816010481 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 655816010482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816010483 DNA-binding site [nucleotide binding]; DNA binding site 655816010484 UTRA domain; Region: UTRA; pfam07702 655816010485 Lamin Tail Domain; Region: LTD; pfam00932 655816010486 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 655816010487 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655816010488 putative active site [active] 655816010489 putative metal binding site [ion binding]; other site 655816010490 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816010491 MarR family; Region: MarR; pfam01047 655816010492 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 655816010493 Cytochrome P450; Region: p450; cl12078 655816010494 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816010495 MarR family; Region: MarR; pfam01047 655816010496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010497 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816010498 putative substrate translocation pore; other site 655816010499 Predicted membrane protein [Function unknown]; Region: COG1950 655816010500 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 655816010501 Uncharacterized conserved protein [Function unknown]; Region: COG3595 655816010502 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 655816010503 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 655816010504 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 655816010505 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 655816010506 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 655816010507 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 655816010508 excinuclease ABC subunit B; Provisional; Region: PRK05298 655816010509 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816010510 ATP binding site [chemical binding]; other site 655816010511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816010512 nucleotide binding region [chemical binding]; other site 655816010513 ATP-binding site [chemical binding]; other site 655816010514 Ultra-violet resistance protein B; Region: UvrB; pfam12344 655816010515 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 655816010516 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 655816010517 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 655816010518 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 655816010519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816010520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816010521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816010523 putative substrate translocation pore; other site 655816010524 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 655816010525 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655816010526 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 655816010527 C-terminal peptidase (prc); Region: prc; TIGR00225 655816010528 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 655816010529 protein binding site [polypeptide binding]; other site 655816010530 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 655816010531 Catalytic dyad [active] 655816010532 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 655816010533 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 655816010534 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 655816010535 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 655816010536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655816010537 Walker A/P-loop; other site 655816010538 ATP binding site [chemical binding]; other site 655816010539 Q-loop/lid; other site 655816010540 ABC transporter signature motif; other site 655816010541 Walker B; other site 655816010542 D-loop; other site 655816010543 H-loop/switch region; other site 655816010544 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 655816010545 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 655816010546 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816010547 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816010548 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816010549 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 655816010550 peptide chain release factor 2; Provisional; Region: PRK06746 655816010551 This domain is found in peptide chain release factors; Region: PCRF; smart00937 655816010552 RF-1 domain; Region: RF-1; pfam00472 655816010553 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 655816010554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 655816010555 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 655816010556 nucleotide binding region [chemical binding]; other site 655816010557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 655816010558 ATP-binding site [chemical binding]; other site 655816010559 SEC-C motif; Region: SEC-C; pfam02810 655816010560 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 655816010561 30S subunit binding site; other site 655816010562 Flagellar protein FliT; Region: FliT; pfam05400 655816010563 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 655816010564 flagellar capping protein; Validated; Region: fliD; PRK07737 655816010565 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 655816010566 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 655816010567 flagellar protein FlaG; Provisional; Region: PRK07738 655816010568 flagellin; Provisional; Region: PRK12804 655816010569 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 655816010570 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 655816010571 carbon storage regulator; Provisional; Region: PRK01712 655816010572 flagellar assembly protein FliW; Provisional; Region: PRK13285 655816010573 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 655816010574 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 655816010575 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 655816010576 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 655816010577 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 655816010578 FlgN protein; Region: FlgN; pfam05130 655816010579 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 655816010580 flagellar operon protein TIGR03826; Region: YvyF 655816010581 comF family protein; Region: comF; TIGR00201 655816010582 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816010583 active site 655816010584 Late competence development protein ComFB; Region: ComFB; pfam10719 655816010585 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 655816010586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816010587 ATP binding site [chemical binding]; other site 655816010588 putative Mg++ binding site [ion binding]; other site 655816010589 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816010590 nucleotide binding region [chemical binding]; other site 655816010591 ATP-binding site [chemical binding]; other site 655816010592 EDD domain protein, DegV family; Region: DegV; TIGR00762 655816010593 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 655816010594 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816010595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816010596 active site 655816010597 phosphorylation site [posttranslational modification] 655816010598 intermolecular recognition site; other site 655816010599 dimerization interface [polypeptide binding]; other site 655816010600 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816010601 DNA binding residues [nucleotide binding] 655816010602 dimerization interface [polypeptide binding]; other site 655816010603 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816010604 Histidine kinase; Region: HisKA_3; pfam07730 655816010605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816010606 ATP binding site [chemical binding]; other site 655816010607 Mg2+ binding site [ion binding]; other site 655816010608 G-X-G motif; other site 655816010609 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 655816010610 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 655816010611 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 655816010612 Transcriptional regulator [Transcription]; Region: LytR; COG1316 655816010613 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 655816010614 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 655816010615 Mg++ binding site [ion binding]; other site 655816010616 putative catalytic motif [active] 655816010617 substrate binding site [chemical binding]; other site 655816010618 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 655816010619 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816010620 putative homodimer interface [polypeptide binding]; other site 655816010621 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 655816010622 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010623 active site 655816010624 Chain length determinant protein; Region: Wzz; cl15801 655816010625 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 655816010626 O-Antigen ligase; Region: Wzy_C; pfam04932 655816010627 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 655816010628 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 655816010629 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 655816010630 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 655816010631 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816010632 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 655816010633 colanic acid exporter; Provisional; Region: PRK10459 655816010634 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 655816010635 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 655816010636 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 655816010637 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010638 active site 655816010639 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 655816010640 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 655816010641 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 655816010642 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 655816010643 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 655816010644 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 655816010645 active site 655816010646 metal binding site [ion binding]; metal-binding site 655816010647 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 655816010648 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 655816010649 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 655816010650 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 655816010651 Stage II sporulation protein; Region: SpoIID; pfam08486 655816010652 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 655816010653 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 655816010654 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 655816010655 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 655816010656 active site 655816010657 homodimer interface [polypeptide binding]; other site 655816010658 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 655816010659 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010660 active site 655816010661 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 655816010662 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 655816010663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816010664 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 655816010665 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 655816010666 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 655816010667 active site 655816010668 tetramer interface; other site 655816010669 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 655816010670 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 655816010671 Walker A/P-loop; other site 655816010672 ATP binding site [chemical binding]; other site 655816010673 Q-loop/lid; other site 655816010674 ABC transporter signature motif; other site 655816010675 Walker B; other site 655816010676 D-loop; other site 655816010677 H-loop/switch region; other site 655816010678 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 655816010679 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 655816010680 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010681 active site 655816010682 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 655816010683 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 655816010684 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 655816010685 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010686 active site 655816010687 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 655816010688 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 655816010689 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 655816010690 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 655816010691 active site 655816010692 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 655816010693 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 655816010694 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 655816010695 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 655816010696 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 655816010697 substrate binding site; other site 655816010698 dimer interface; other site 655816010699 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 655816010700 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655816010701 putative NAD(P) binding site [chemical binding]; other site 655816010702 putative catalytic Zn binding site [ion binding]; other site 655816010703 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 655816010704 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 655816010705 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 655816010706 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 655816010707 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 655816010708 Bacterial SH3 domain; Region: SH3_3; pfam08239 655816010709 Lysozyme subfamily 2; Region: LYZ2; smart00047 655816010710 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 655816010711 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 655816010712 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 655816010713 Spore germination protein; Region: Spore_permease; pfam03845 655816010714 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 655816010715 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 655816010716 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 655816010717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010718 putative substrate translocation pore; other site 655816010719 Transcriptional regulator [Transcription]; Region: LytR; COG1316 655816010720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816010721 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 655816010722 active site 655816010723 motif I; other site 655816010724 motif II; other site 655816010725 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 655816010726 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 655816010727 NlpC/P60 family; Region: NLPC_P60; pfam00877 655816010728 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 655816010729 NlpC/P60 family; Region: NLPC_P60; pfam00877 655816010730 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 655816010731 NlpC/P60 family; Region: NLPC_P60; pfam00877 655816010732 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 655816010733 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 655816010734 putative active site [active] 655816010735 putative metal binding site [ion binding]; other site 655816010736 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 655816010737 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 655816010738 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655816010739 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816010740 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816010741 DNA binding site [nucleotide binding] 655816010742 domain linker motif; other site 655816010743 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 655816010744 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655816010745 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 655816010746 substrate binding site [chemical binding]; other site 655816010747 dimer interface [polypeptide binding]; other site 655816010748 ATP binding site [chemical binding]; other site 655816010749 D-ribose pyranase; Provisional; Region: PRK11797 655816010750 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 655816010751 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 655816010752 Walker A/P-loop; other site 655816010753 ATP binding site [chemical binding]; other site 655816010754 Q-loop/lid; other site 655816010755 ABC transporter signature motif; other site 655816010756 Walker B; other site 655816010757 D-loop; other site 655816010758 H-loop/switch region; other site 655816010759 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 655816010760 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 655816010761 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 655816010762 TM-ABC transporter signature motif; other site 655816010763 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 655816010764 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 655816010765 ligand binding site [chemical binding]; other site 655816010766 dimerization interface [polypeptide binding]; other site 655816010767 Bacterial SH3 domain homologues; Region: SH3b; smart00287 655816010768 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 655816010769 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 655816010770 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 655816010771 acetolactate synthase; Reviewed; Region: PRK08617 655816010772 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 655816010773 PYR/PP interface [polypeptide binding]; other site 655816010774 dimer interface [polypeptide binding]; other site 655816010775 TPP binding site [chemical binding]; other site 655816010776 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 655816010777 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 655816010778 TPP-binding site [chemical binding]; other site 655816010779 dimer interface [polypeptide binding]; other site 655816010780 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 655816010781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816010782 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 655816010783 putative dimerization interface [polypeptide binding]; other site 655816010784 putative substrate binding pocket [chemical binding]; other site 655816010785 CotH protein; Region: CotH; pfam08757 655816010786 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 655816010787 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 655816010788 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 655816010789 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 655816010790 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 655816010791 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816010792 putative DNA binding site [nucleotide binding]; other site 655816010793 putative Zn2+ binding site [ion binding]; other site 655816010794 AsnC family; Region: AsnC_trans_reg; pfam01037 655816010795 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 655816010796 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 655816010797 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 655816010798 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 655816010799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816010800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816010801 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655816010802 dimerization interface [polypeptide binding]; other site 655816010803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 655816010804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 655816010805 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 655816010806 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 655816010807 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 655816010808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816010809 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 655816010810 Active_site [active] 655816010811 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 655816010812 LXG domain of WXG superfamily; Region: LXG; pfam04740 655816010813 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 655816010814 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 655816010815 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 655816010816 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 655816010817 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 655816010818 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 655816010819 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 655816010820 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 655816010821 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 655816010822 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 655816010823 Chain length determinant protein; Region: Wzz; cl15801 655816010824 SWIM zinc finger; Region: SWIM; pfam04434 655816010825 SNF2 Helicase protein; Region: DUF3670; pfam12419 655816010826 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 655816010827 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816010828 ATP binding site [chemical binding]; other site 655816010829 putative Mg++ binding site [ion binding]; other site 655816010830 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 655816010831 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816010832 nucleotide binding region [chemical binding]; other site 655816010833 ATP-binding site [chemical binding]; other site 655816010834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816010835 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 655816010836 active site 655816010837 motif I; other site 655816010838 motif II; other site 655816010839 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816010840 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655816010841 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 655816010842 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655816010843 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 655816010844 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 655816010845 dimer interface [polypeptide binding]; other site 655816010846 ssDNA binding site [nucleotide binding]; other site 655816010847 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816010848 YwpF-like protein; Region: YwpF; pfam14183 655816010849 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 655816010850 active site 655816010851 catalytic site [active] 655816010852 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 655816010853 Collagen binding domain; Region: Collagen_bind; pfam05737 655816010854 Collagen binding domain; Region: Collagen_bind; pfam05737 655816010855 Collagen binding domain; Region: Collagen_bind; pfam05737 655816010856 Collagen binding domain; Region: Collagen_bind; pfam05737 655816010857 Cna protein B-type domain; Region: Cna_B; pfam05738 655816010858 Cna protein B-type domain; Region: Cna_B; pfam05738 655816010859 Cna protein B-type domain; Region: Cna_B; pfam05738 655816010860 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 655816010861 Cna protein B-type domain; Region: Cna_B; pfam05738 655816010862 Cna protein B-type domain; Region: Cna_B; pfam05738 655816010863 Cna protein B-type domain; Region: Cna_B; pfam05738 655816010864 Cna protein B-type domain; Region: Cna_B; pfam05738 655816010865 Cna protein B-type domain; Region: Cna_B; pfam05738 655816010866 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 655816010867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816010868 active site 655816010869 phosphorylation site [posttranslational modification] 655816010870 intermolecular recognition site; other site 655816010871 dimerization interface [polypeptide binding]; other site 655816010872 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 655816010873 DNA binding site [nucleotide binding] 655816010874 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 655816010875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816010876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816010877 dimer interface [polypeptide binding]; other site 655816010878 phosphorylation site [posttranslational modification] 655816010879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816010880 ATP binding site [chemical binding]; other site 655816010881 Mg2+ binding site [ion binding]; other site 655816010882 G-X-G motif; other site 655816010883 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 655816010884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816010885 active site 655816010886 phosphorylation site [posttranslational modification] 655816010887 intermolecular recognition site; other site 655816010888 dimerization interface [polypeptide binding]; other site 655816010889 Histidine kinase; Region: His_kinase; pfam06580 655816010890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816010891 ATP binding site [chemical binding]; other site 655816010892 Mg2+ binding site [ion binding]; other site 655816010893 G-X-G motif; other site 655816010894 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 655816010895 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 655816010896 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 655816010897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816010898 binding surface 655816010899 TPR motif; other site 655816010900 Tetratricopeptide repeat; Region: TPR_16; pfam13432 655816010901 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 655816010902 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 655816010903 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 655816010904 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 655816010905 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 655816010906 rod shape-determining protein Mbl; Provisional; Region: PRK13928 655816010907 MreB and similar proteins; Region: MreB_like; cd10225 655816010908 nucleotide binding site [chemical binding]; other site 655816010909 Mg binding site [ion binding]; other site 655816010910 putative protofilament interaction site [polypeptide binding]; other site 655816010911 RodZ interaction site [polypeptide binding]; other site 655816010912 Stage III sporulation protein D; Region: SpoIIID; pfam12116 655816010913 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816010914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816010915 putative DNA binding site [nucleotide binding]; other site 655816010916 putative Zn2+ binding site [ion binding]; other site 655816010917 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816010918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010919 putative substrate translocation pore; other site 655816010920 Right handed beta helix region; Region: Beta_helix; pfam13229 655816010921 Right handed beta helix region; Region: Beta_helix; pfam13229 655816010922 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 655816010923 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 655816010924 Na binding site [ion binding]; other site 655816010925 putative substrate binding site [chemical binding]; other site 655816010926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010927 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816010928 putative substrate translocation pore; other site 655816010929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010930 Isochorismatase family; Region: Isochorismatase; pfam00857 655816010931 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 655816010932 catalytic triad [active] 655816010933 conserved cis-peptide bond; other site 655816010934 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 655816010935 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 655816010936 Nitrogen regulatory protein P-II; Region: P-II; smart00938 655816010937 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 655816010938 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 655816010939 active site 655816010940 VanZ like family; Region: VanZ; pfam04892 655816010941 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 655816010942 Peptidase family M23; Region: Peptidase_M23; pfam01551 655816010943 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 655816010944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816010945 Coenzyme A binding pocket [chemical binding]; other site 655816010946 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 655816010947 NeuB family; Region: NeuB; pfam03102 655816010948 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 655816010949 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 655816010950 ligand binding site; other site 655816010951 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 655816010952 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 655816010953 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 655816010954 putative active site [active] 655816010955 catalytic site [active] 655816010956 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 655816010957 putative active site [active] 655816010958 catalytic site [active] 655816010959 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 655816010960 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 655816010961 DNA binding residues [nucleotide binding] 655816010962 dimer interface [polypeptide binding]; other site 655816010963 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 655816010964 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 655816010965 NADH(P)-binding; Region: NAD_binding_10; pfam13460 655816010966 NAD binding site [chemical binding]; other site 655816010967 substrate binding site [chemical binding]; other site 655816010968 putative active site [active] 655816010969 Predicted transcriptional regulator [Transcription]; Region: COG1959 655816010970 Transcriptional regulator; Region: Rrf2; pfam02082 655816010971 urease subunit alpha; Reviewed; Region: ureC; PRK13207 655816010972 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 655816010973 subunit interactions [polypeptide binding]; other site 655816010974 active site 655816010975 flap region; other site 655816010976 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 655816010977 gamma-beta subunit interface [polypeptide binding]; other site 655816010978 alpha-beta subunit interface [polypeptide binding]; other site 655816010979 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 655816010980 alpha-gamma subunit interface [polypeptide binding]; other site 655816010981 beta-gamma subunit interface [polypeptide binding]; other site 655816010982 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 655816010983 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 655816010984 Walker A/P-loop; other site 655816010985 ATP binding site [chemical binding]; other site 655816010986 Q-loop/lid; other site 655816010987 ABC transporter signature motif; other site 655816010988 Walker B; other site 655816010989 D-loop; other site 655816010990 H-loop/switch region; other site 655816010991 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 655816010992 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 655816010993 Walker A/P-loop; other site 655816010994 ATP binding site [chemical binding]; other site 655816010995 Q-loop/lid; other site 655816010996 ABC transporter signature motif; other site 655816010997 Walker B; other site 655816010998 D-loop; other site 655816010999 H-loop/switch region; other site 655816011000 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 655816011001 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 655816011002 TM-ABC transporter signature motif; other site 655816011003 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 655816011004 TM-ABC transporter signature motif; other site 655816011005 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 655816011006 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 655816011007 putative ligand binding site [chemical binding]; other site 655816011008 CsbD-like; Region: CsbD; pfam05532 655816011009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 655816011010 binding surface 655816011011 TPR motif; other site 655816011012 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816011013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816011014 binding surface 655816011015 TPR motif; other site 655816011016 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 655816011017 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816011018 FeS/SAM binding site; other site 655816011019 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 655816011020 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 655816011021 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 655816011022 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 655816011023 metal ion-dependent adhesion site (MIDAS); other site 655816011024 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 655816011025 metal ion-dependent adhesion site (MIDAS); other site 655816011026 stage II sporulation protein D; Region: spore_II_D; TIGR02870 655816011027 Stage II sporulation protein; Region: SpoIID; pfam08486 655816011028 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 655816011029 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 655816011030 hinge; other site 655816011031 active site 655816011032 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 655816011033 Predicted membrane protein [Function unknown]; Region: COG4836 655816011034 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 655816011035 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 655816011036 gamma subunit interface [polypeptide binding]; other site 655816011037 epsilon subunit interface [polypeptide binding]; other site 655816011038 LBP interface [polypeptide binding]; other site 655816011039 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 655816011040 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 655816011041 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 655816011042 alpha subunit interaction interface [polypeptide binding]; other site 655816011043 Walker A motif; other site 655816011044 ATP binding site [chemical binding]; other site 655816011045 Walker B motif; other site 655816011046 inhibitor binding site; inhibition site 655816011047 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 655816011048 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 655816011049 core domain interface [polypeptide binding]; other site 655816011050 delta subunit interface [polypeptide binding]; other site 655816011051 epsilon subunit interface [polypeptide binding]; other site 655816011052 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 655816011053 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 655816011054 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 655816011055 beta subunit interaction interface [polypeptide binding]; other site 655816011056 Walker A motif; other site 655816011057 ATP binding site [chemical binding]; other site 655816011058 Walker B motif; other site 655816011059 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 655816011060 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 655816011061 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 655816011062 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 655816011063 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 655816011064 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 655816011065 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 655816011066 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 655816011067 ATP synthase I chain; Region: ATP_synt_I; pfam03899 655816011068 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816011069 active site 655816011070 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 655816011071 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 655816011072 dimer interface [polypeptide binding]; other site 655816011073 active site 655816011074 glycine-pyridoxal phosphate binding site [chemical binding]; other site 655816011075 folate binding site [chemical binding]; other site 655816011076 hypothetical protein; Provisional; Region: PRK13690 655816011077 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 655816011078 Low molecular weight phosphatase family; Region: LMWPc; cd00115 655816011079 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 655816011080 active site 655816011081 Predicted membrane protein [Function unknown]; Region: COG1971 655816011082 Domain of unknown function DUF; Region: DUF204; pfam02659 655816011083 Domain of unknown function DUF; Region: DUF204; pfam02659 655816011084 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 655816011085 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 655816011086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 655816011087 stage II sporulation protein R; Region: spore_II_R; TIGR02837 655816011088 HemK family putative methylases; Region: hemK_fam; TIGR00536 655816011089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816011090 S-adenosylmethionine binding site [chemical binding]; other site 655816011091 peptide chain release factor 1; Validated; Region: prfA; PRK00591 655816011092 This domain is found in peptide chain release factors; Region: PCRF; smart00937 655816011093 RF-1 domain; Region: RF-1; pfam00472 655816011094 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 655816011095 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816011096 putative metal binding site [ion binding]; other site 655816011097 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 655816011098 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 655816011099 DNA binding residues [nucleotide binding] 655816011100 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 655816011101 malate dehydrogenase; Provisional; Region: PRK13529 655816011102 Malic enzyme, N-terminal domain; Region: malic; pfam00390 655816011103 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 655816011104 NAD(P) binding site [chemical binding]; other site 655816011105 thymidine kinase; Provisional; Region: PRK04296 655816011106 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 655816011107 transcription termination factor Rho; Provisional; Region: rho; PRK09376 655816011108 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 655816011109 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 655816011110 RNA binding site [nucleotide binding]; other site 655816011111 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 655816011112 multimer interface [polypeptide binding]; other site 655816011113 Walker A motif; other site 655816011114 ATP binding site [chemical binding]; other site 655816011115 Walker B motif; other site 655816011116 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 655816011117 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 655816011118 putative active site [active] 655816011119 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 655816011120 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 655816011121 hinge; other site 655816011122 active site 655816011123 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 655816011124 active site 655816011125 intersubunit interactions; other site 655816011126 catalytic residue [active] 655816011127 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 655816011128 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 655816011129 intersubunit interface [polypeptide binding]; other site 655816011130 active site 655816011131 zinc binding site [ion binding]; other site 655816011132 Na+ binding site [ion binding]; other site 655816011133 Response regulator receiver domain; Region: Response_reg; pfam00072 655816011134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816011135 active site 655816011136 phosphorylation site [posttranslational modification] 655816011137 intermolecular recognition site; other site 655816011138 dimerization interface [polypeptide binding]; other site 655816011139 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 655816011140 CTP synthetase; Validated; Region: pyrG; PRK05380 655816011141 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 655816011142 Catalytic site [active] 655816011143 active site 655816011144 UTP binding site [chemical binding]; other site 655816011145 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 655816011146 active site 655816011147 putative oxyanion hole; other site 655816011148 catalytic triad [active] 655816011149 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 655816011150 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 655816011151 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 655816011152 FAD binding site [chemical binding]; other site 655816011153 homotetramer interface [polypeptide binding]; other site 655816011154 substrate binding pocket [chemical binding]; other site 655816011155 catalytic base [active] 655816011156 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 655816011157 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 655816011158 Cysteine-rich domain; Region: CCG; pfam02754 655816011159 Cysteine-rich domain; Region: CCG; pfam02754 655816011160 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 655816011161 PLD-like domain; Region: PLDc_2; pfam13091 655816011162 putative active site [active] 655816011163 catalytic site [active] 655816011164 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 655816011165 PLD-like domain; Region: PLDc_2; pfam13091 655816011166 putative active site [active] 655816011167 catalytic site [active] 655816011168 UV-endonuclease UvdE; Region: UvdE; cl10036 655816011169 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 655816011170 folate binding site [chemical binding]; other site 655816011171 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 655816011172 NADP+ binding site [chemical binding]; other site 655816011173 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816011174 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655816011175 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 655816011176 Walker A/P-loop; other site 655816011177 ATP binding site [chemical binding]; other site 655816011178 Q-loop/lid; other site 655816011179 ABC transporter signature motif; other site 655816011180 Walker B; other site 655816011181 D-loop; other site 655816011182 H-loop/switch region; other site 655816011183 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 655816011184 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 655816011185 putative active site [active] 655816011186 catalytic site [active] 655816011187 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 655816011188 putative active site [active] 655816011189 catalytic site [active] 655816011190 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816011191 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816011192 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 655816011193 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 655816011194 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 655816011195 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 655816011196 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 655816011197 [4Fe-4S] binding site [ion binding]; other site 655816011198 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655816011199 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655816011200 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655816011201 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 655816011202 molybdopterin cofactor binding site; other site 655816011203 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 655816011204 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 655816011205 ligand binding site [chemical binding]; other site 655816011206 flexible hinge region; other site 655816011207 YwiC-like protein; Region: YwiC; pfam14256 655816011208 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 655816011209 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 655816011210 ligand binding site [chemical binding]; other site 655816011211 flexible hinge region; other site 655816011212 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 655816011213 putative switch regulator; other site 655816011214 non-specific DNA interactions [nucleotide binding]; other site 655816011215 DNA binding site [nucleotide binding] 655816011216 sequence specific DNA binding site [nucleotide binding]; other site 655816011217 putative cAMP binding site [chemical binding]; other site 655816011218 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 655816011219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011220 putative substrate translocation pore; other site 655816011221 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 655816011222 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 655816011223 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 655816011224 active site 655816011225 HIGH motif; other site 655816011226 KMSK motif region; other site 655816011227 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 655816011228 tRNA binding surface [nucleotide binding]; other site 655816011229 anticodon binding site; other site 655816011230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 655816011231 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 655816011232 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 655816011233 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 655816011234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816011235 FeS/SAM binding site; other site 655816011236 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 655816011237 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 655816011238 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 655816011239 Walker A/P-loop; other site 655816011240 ATP binding site [chemical binding]; other site 655816011241 Q-loop/lid; other site 655816011242 ABC transporter signature motif; other site 655816011243 Walker B; other site 655816011244 D-loop; other site 655816011245 H-loop/switch region; other site 655816011246 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 655816011247 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 655816011248 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 655816011249 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 655816011250 Uncharacterized conserved protein [Function unknown]; Region: COG3391 655816011251 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 655816011252 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816011253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816011254 TPR motif; other site 655816011255 binding surface 655816011256 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816011257 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 655816011258 agmatinase; Region: agmatinase; TIGR01230 655816011259 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 655816011260 putative active site [active] 655816011261 Mn binding site [ion binding]; other site 655816011262 spermidine synthase; Provisional; Region: PRK00811 655816011263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816011264 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 655816011265 Transglycosylase; Region: Transgly; pfam00912 655816011266 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 655816011267 YwhD family; Region: YwhD; pfam08741 655816011268 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 655816011269 Peptidase family M50; Region: Peptidase_M50; pfam02163 655816011270 active site 655816011271 putative substrate binding region [chemical binding]; other site 655816011272 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 655816011273 active site 1 [active] 655816011274 dimer interface [polypeptide binding]; other site 655816011275 hexamer interface [polypeptide binding]; other site 655816011276 active site 2 [active] 655816011277 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816011278 MarR family; Region: MarR; pfam01047 655816011279 MarR family; Region: MarR_2; cl17246 655816011280 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 655816011281 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 655816011282 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 655816011283 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 655816011284 active site 655816011285 dimer interface [polypeptide binding]; other site 655816011286 motif 1; other site 655816011287 motif 2; other site 655816011288 motif 3; other site 655816011289 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 655816011290 anticodon binding site; other site 655816011291 Uncharacterized conserved protein [Function unknown]; Region: COG3465 655816011292 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 655816011293 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816011294 Zn2+ binding site [ion binding]; other site 655816011295 Mg2+ binding site [ion binding]; other site 655816011296 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 655816011297 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 655816011298 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 655816011299 EamA-like transporter family; Region: EamA; pfam00892 655816011300 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 655816011301 EamA-like transporter family; Region: EamA; pfam00892 655816011302 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 655816011303 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816011304 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816011305 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 655816011306 putative dimerization interface [polypeptide binding]; other site 655816011307 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 655816011308 putative heme peroxidase; Provisional; Region: PRK12276 655816011309 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 655816011310 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 655816011311 putative NAD(P) binding site [chemical binding]; other site 655816011312 putative active site [active] 655816011313 transaminase; Reviewed; Region: PRK08068 655816011314 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816011315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816011316 homodimer interface [polypeptide binding]; other site 655816011317 catalytic residue [active] 655816011318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011319 putative substrate translocation pore; other site 655816011320 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 655816011321 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 655816011322 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 655816011323 classical (c) SDRs; Region: SDR_c; cd05233 655816011324 NAD(P) binding site [chemical binding]; other site 655816011325 active site 655816011326 Cupin domain; Region: Cupin_2; pfam07883 655816011327 Cupin domain; Region: Cupin_2; pfam07883 655816011328 Prephenate dehydratase; Region: PDT; pfam00800 655816011329 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 655816011330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011331 putative substrate translocation pore; other site 655816011332 S-methylmethionine transporter; Provisional; Region: PRK11387 655816011333 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 655816011334 putative metal binding site [ion binding]; other site 655816011335 putative dimer interface [polypeptide binding]; other site 655816011336 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 655816011337 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 655816011338 Glutamate binding site [chemical binding]; other site 655816011339 homodimer interface [polypeptide binding]; other site 655816011340 NAD binding site [chemical binding]; other site 655816011341 catalytic residues [active] 655816011342 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 655816011343 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 655816011344 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 655816011345 NAD(P) binding site [chemical binding]; other site 655816011346 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 655816011347 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 655816011348 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 655816011349 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 655816011350 NADP binding site [chemical binding]; other site 655816011351 active site 655816011352 putative substrate binding site [chemical binding]; other site 655816011353 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 655816011354 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 655816011355 NAD binding site [chemical binding]; other site 655816011356 substrate binding site [chemical binding]; other site 655816011357 homodimer interface [polypeptide binding]; other site 655816011358 active site 655816011359 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 655816011360 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 655816011361 substrate binding site; other site 655816011362 tetramer interface; other site 655816011363 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 655816011364 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 655816011365 ligand binding site; other site 655816011366 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 655816011367 NeuB family; Region: NeuB; pfam03102 655816011368 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 655816011369 NeuB binding interface [polypeptide binding]; other site 655816011370 putative substrate binding site [chemical binding]; other site 655816011371 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816011372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816011373 Coenzyme A binding pocket [chemical binding]; other site 655816011374 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 655816011375 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 655816011376 inhibitor-cofactor binding pocket; inhibition site 655816011377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816011378 catalytic residue [active] 655816011379 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 655816011380 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 655816011381 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 655816011382 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816011383 active site 655816011384 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 655816011385 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 655816011386 Permease family; Region: Xan_ur_permease; pfam00860 655816011387 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 655816011388 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 655816011389 NAD(P) binding site [chemical binding]; other site 655816011390 catalytic residues [active] 655816011391 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 655816011392 ligand binding site [chemical binding]; other site 655816011393 active site 655816011394 UGI interface [polypeptide binding]; other site 655816011395 catalytic site [active] 655816011396 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 655816011397 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816011398 active site 655816011399 Ceramidase; Region: Ceramidase; pfam05875 655816011400 Predicted transcriptional regulators [Transcription]; Region: COG1695 655816011401 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816011402 putative DNA binding site [nucleotide binding]; other site 655816011403 putative Zn2+ binding site [ion binding]; other site 655816011404 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 655816011405 dimer interface [polypeptide binding]; other site 655816011406 substrate binding site [chemical binding]; other site 655816011407 ATP binding site [chemical binding]; other site 655816011408 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 655816011409 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 655816011410 substrate binding [chemical binding]; other site 655816011411 active site 655816011412 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 655816011413 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 655816011414 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816011415 active site turn [active] 655816011416 phosphorylation site [posttranslational modification] 655816011417 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655816011418 formate/nitrite transporter; Region: fnt; TIGR00790 655816011419 transcriptional antiterminator BglG; Provisional; Region: PRK09772 655816011420 CAT RNA binding domain; Region: CAT_RBD; smart01061 655816011421 PRD domain; Region: PRD; pfam00874 655816011422 PRD domain; Region: PRD; pfam00874 655816011423 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 655816011424 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 655816011425 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 655816011426 putative active site [active] 655816011427 catalytic triad [active] 655816011428 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 655816011429 PA/protease domain interface [polypeptide binding]; other site 655816011430 putative integrin binding motif; other site 655816011431 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 655816011432 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 655816011433 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 655816011434 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 655816011435 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 655816011436 dimer interface [polypeptide binding]; other site 655816011437 FMN binding site [chemical binding]; other site 655816011438 NADPH bind site [chemical binding]; other site 655816011439 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 655816011440 Sterol carrier protein domain; Region: SCP2_2; pfam13530 655816011441 Sterol carrier protein domain; Region: SCP2_2; pfam13530 655816011442 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 655816011443 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 655816011444 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 655816011445 Subunit I/III interface [polypeptide binding]; other site 655816011446 Subunit III/IV interface [polypeptide binding]; other site 655816011447 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 655816011448 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 655816011449 D-pathway; other site 655816011450 Putative ubiquinol binding site [chemical binding]; other site 655816011451 Low-spin heme (heme b) binding site [chemical binding]; other site 655816011452 Putative water exit pathway; other site 655816011453 Binuclear center (heme o3/CuB) [ion binding]; other site 655816011454 K-pathway; other site 655816011455 Putative proton exit pathway; other site 655816011456 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 655816011457 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 655816011458 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 655816011459 Predicted membrane protein [Function unknown]; Region: COG2261 655816011460 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 655816011461 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 655816011462 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 655816011463 galactokinase; Provisional; Region: PRK05322 655816011464 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 655816011465 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 655816011466 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 655816011467 Predicted membrane protein [Function unknown]; Region: COG2246 655816011468 GtrA-like protein; Region: GtrA; pfam04138 655816011469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816011470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816011471 Anti-repressor SinI; Region: SinI; pfam08671 655816011472 Predicted membrane protein [Function unknown]; Region: COG3162 655816011473 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 655816011474 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 655816011475 Na binding site [ion binding]; other site 655816011476 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 655816011477 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 655816011478 catalytic residues [active] 655816011479 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 655816011480 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 655816011481 Imelysin; Region: Peptidase_M75; cl09159 655816011482 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 655816011483 thiamine phosphate binding site [chemical binding]; other site 655816011484 active site 655816011485 pyrophosphate binding site [ion binding]; other site 655816011486 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 655816011487 substrate binding site [chemical binding]; other site 655816011488 multimerization interface [polypeptide binding]; other site 655816011489 ATP binding site [chemical binding]; other site 655816011490 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816011491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816011492 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 655816011493 putative dimerization interface [polypeptide binding]; other site 655816011494 holin-like protein; Validated; Region: PRK01658 655816011495 TIGR00659 family protein; Region: TIGR00659 655816011496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655816011497 Walker A/P-loop; other site 655816011498 ATP binding site [chemical binding]; other site 655816011499 ABC transporter; Region: ABC_tran; pfam00005 655816011500 Q-loop/lid; other site 655816011501 ABC transporter signature motif; other site 655816011502 Walker B; other site 655816011503 D-loop; other site 655816011504 H-loop/switch region; other site 655816011505 LrgB-like family; Region: LrgB; cl00596 655816011506 sugar efflux transporter; Region: 2A0120; TIGR00899 655816011507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011508 putative substrate translocation pore; other site 655816011509 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 655816011510 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 655816011511 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 655816011512 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 655816011513 putative RNA binding site [nucleotide binding]; other site 655816011514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816011515 S-adenosylmethionine binding site [chemical binding]; other site 655816011516 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816011517 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 655816011518 active site 655816011519 metal binding site [ion binding]; metal-binding site 655816011520 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 655816011521 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 655816011522 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 655816011523 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 655816011524 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 655816011525 active site 655816011526 catalytic residues [active] 655816011527 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 655816011528 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816011529 active site turn [active] 655816011530 phosphorylation site [posttranslational modification] 655816011531 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655816011532 transcriptional antiterminator BglG; Provisional; Region: PRK09772 655816011533 CAT RNA binding domain; Region: CAT_RBD; pfam03123 655816011534 PRD domain; Region: PRD; pfam00874 655816011535 PRD domain; Region: PRD; pfam00874 655816011536 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 655816011537 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 655816011538 Ligand binding site; other site 655816011539 metal-binding site 655816011540 Predicted integral membrane protein [Function unknown]; Region: COG5522 655816011541 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816011542 MarR family; Region: MarR; pfam01047 655816011543 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 655816011544 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 655816011545 active site 655816011546 HIGH motif; other site 655816011547 dimer interface [polypeptide binding]; other site 655816011548 KMSKS motif; other site 655816011549 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816011550 RNA binding surface [nucleotide binding]; other site 655816011551 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 655816011552 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 655816011553 PA/protease domain interface [polypeptide binding]; other site 655816011554 putative integrin binding motif; other site 655816011555 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 655816011556 Peptidase family M28; Region: Peptidase_M28; pfam04389 655816011557 metal binding site [ion binding]; metal-binding site 655816011558 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 655816011559 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 655816011560 synthetase active site [active] 655816011561 NTP binding site [chemical binding]; other site 655816011562 metal binding site [ion binding]; metal-binding site 655816011563 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 655816011564 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 655816011565 UbiA prenyltransferase family; Region: UbiA; pfam01040 655816011566 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 655816011567 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 655816011568 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 655816011569 acyl-activating enzyme (AAE) consensus motif; other site 655816011570 AMP binding site [chemical binding]; other site 655816011571 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 655816011572 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 655816011573 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 655816011574 DltD N-terminal region; Region: DltD_N; pfam04915 655816011575 DltD central region; Region: DltD_M; pfam04918 655816011576 DltD C-terminal region; Region: DltD_C; pfam04914 655816011577 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 655816011578 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 655816011579 putative NAD(P) binding site [chemical binding]; other site 655816011580 active site 655816011581 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 655816011582 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 655816011583 homodimer interface [polypeptide binding]; other site 655816011584 substrate-cofactor binding pocket; other site 655816011585 catalytic residue [active] 655816011586 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 655816011587 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 655816011588 NAD binding site [chemical binding]; other site 655816011589 sugar binding site [chemical binding]; other site 655816011590 divalent metal binding site [ion binding]; other site 655816011591 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816011592 dimer interface [polypeptide binding]; other site 655816011593 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 655816011594 methionine cluster; other site 655816011595 active site 655816011596 phosphorylation site [posttranslational modification] 655816011597 metal binding site [ion binding]; metal-binding site 655816011598 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 655816011599 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 655816011600 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 655816011601 active site 655816011602 P-loop; other site 655816011603 phosphorylation site [posttranslational modification] 655816011604 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 655816011605 HTH domain; Region: HTH_11; pfam08279 655816011606 Mga helix-turn-helix domain; Region: Mga; pfam05043 655816011607 PRD domain; Region: PRD; pfam00874 655816011608 PRD domain; Region: PRD; pfam00874 655816011609 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 655816011610 active site 655816011611 P-loop; other site 655816011612 phosphorylation site [posttranslational modification] 655816011613 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655816011614 active site 655816011615 phosphorylation site [posttranslational modification] 655816011616 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 655816011617 active site 655816011618 DNA binding site [nucleotide binding] 655816011619 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 655816011620 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 655816011621 tetramer interface [polypeptide binding]; other site 655816011622 heme binding pocket [chemical binding]; other site 655816011623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011624 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816011625 putative substrate translocation pore; other site 655816011626 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 655816011627 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816011628 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 655816011629 Walker A/P-loop; other site 655816011630 ATP binding site [chemical binding]; other site 655816011631 Q-loop/lid; other site 655816011632 ABC transporter signature motif; other site 655816011633 Walker B; other site 655816011634 D-loop; other site 655816011635 H-loop/switch region; other site 655816011636 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 655816011637 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 655816011638 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 655816011639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816011640 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816011641 DNA binding residues [nucleotide binding] 655816011642 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 655816011643 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 655816011644 Na binding site [ion binding]; other site 655816011645 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 655816011646 putative substrate binding site [chemical binding]; other site 655816011647 putative ATP binding site [chemical binding]; other site 655816011648 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 655816011649 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655816011650 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 655816011651 Walker A/P-loop; other site 655816011652 ATP binding site [chemical binding]; other site 655816011653 Q-loop/lid; other site 655816011654 ABC transporter signature motif; other site 655816011655 Walker B; other site 655816011656 D-loop; other site 655816011657 H-loop/switch region; other site 655816011658 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 655816011659 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655816011660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655816011661 ATP binding site [chemical binding]; other site 655816011662 Q-loop/lid; other site 655816011663 ABC transporter signature motif; other site 655816011664 Walker B; other site 655816011665 D-loop; other site 655816011666 H-loop/switch region; other site 655816011667 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 655816011668 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 655816011669 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 655816011670 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 655816011671 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 655816011672 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 655816011673 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 655816011674 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 655816011675 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 655816011676 putative active site [active] 655816011677 putative metal binding site [ion binding]; other site 655816011678 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 655816011679 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 655816011680 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 655816011681 Walker A/P-loop; other site 655816011682 ATP binding site [chemical binding]; other site 655816011683 Q-loop/lid; other site 655816011684 ABC transporter signature motif; other site 655816011685 Walker B; other site 655816011686 D-loop; other site 655816011687 H-loop/switch region; other site 655816011688 TOBE domain; Region: TOBE; pfam03459 655816011689 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 655816011690 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 655816011691 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 655816011692 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655816011693 NAD(P) binding site [chemical binding]; other site 655816011694 catalytic residues [active] 655816011695 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816011696 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816011697 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816011698 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 655816011699 ykkC-yxkD riboswitch leader; may function to switch on expression of the ykkD efflux pump gene in response to toxic compounds; BSUW23_misc_RNA_60 655816011700 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 655816011701 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 655816011702 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 655816011703 UDP-glucose 4-epimerase; Region: PLN02240 655816011704 NAD binding site [chemical binding]; other site 655816011705 homodimer interface [polypeptide binding]; other site 655816011706 active site 655816011707 substrate binding site [chemical binding]; other site 655816011708 peptidase T; Region: peptidase-T; TIGR01882 655816011709 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 655816011710 metal binding site [ion binding]; metal-binding site 655816011711 dimer interface [polypeptide binding]; other site 655816011712 Uncharacterized conserved protein [Function unknown]; Region: COG4894 655816011713 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 655816011714 substrate binding site [chemical binding]; other site 655816011715 THF binding site; other site 655816011716 zinc-binding site [ion binding]; other site 655816011717 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 655816011718 substrate binding site [chemical binding]; other site 655816011719 THF binding site; other site 655816011720 zinc-binding site [ion binding]; other site 655816011721 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 655816011722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816011723 NAD(P) binding site [chemical binding]; other site 655816011724 active site 655816011725 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 655816011726 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 655816011727 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 655816011728 fructuronate transporter; Provisional; Region: PRK10034; cl15264 655816011729 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 655816011730 Methyltransferase domain; Region: Methyltransf_11; pfam08241 655816011731 nucleoside transporter; Region: nupC; TIGR00804 655816011732 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 655816011733 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 655816011734 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 655816011735 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 655816011736 hydroperoxidase II; Provisional; Region: katE; PRK11249 655816011737 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 655816011738 tetramer interface [polypeptide binding]; other site 655816011739 heme binding pocket [chemical binding]; other site 655816011740 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 655816011741 domain interactions; other site 655816011742 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 655816011743 Citrate transporter; Region: CitMHS; pfam03600 655816011744 Predicted membrane protein [Function unknown]; Region: COG2323 655816011745 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 655816011746 beta-galactosidase; Region: BGL; TIGR03356 655816011747 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 655816011748 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816011749 active site turn [active] 655816011750 phosphorylation site [posttranslational modification] 655816011751 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655816011752 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 655816011753 HPr interaction site; other site 655816011754 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655816011755 active site 655816011756 phosphorylation site [posttranslational modification] 655816011757 transcriptional antiterminator BglG; Provisional; Region: PRK09772 655816011758 CAT RNA binding domain; Region: CAT_RBD; pfam03123 655816011759 PRD domain; Region: PRD; pfam00874 655816011760 PRD domain; Region: PRD; pfam00874 655816011761 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 655816011762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011763 putative substrate translocation pore; other site 655816011764 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 655816011765 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 655816011766 ATP binding site [chemical binding]; other site 655816011767 Mg++ binding site [ion binding]; other site 655816011768 motif III; other site 655816011769 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816011770 nucleotide binding region [chemical binding]; other site 655816011771 ATP-binding site [chemical binding]; other site 655816011772 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 655816011773 RNA binding site [nucleotide binding]; other site 655816011774 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 655816011775 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 655816011776 active site 655816011777 catalytic triad [active] 655816011778 Predicted transcriptional regulators [Transcription]; Region: COG1695 655816011779 Transcriptional regulator PadR-like family; Region: PadR; cl17335 655816011780 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 655816011781 YxiJ-like protein; Region: YxiJ; pfam14176 655816011782 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 655816011783 Uncharacterized conserved protein [Function unknown]; Region: COG2898 655816011784 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 655816011785 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 655816011786 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 655816011787 RHS Repeat; Region: RHS_repeat; pfam05593 655816011788 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 655816011789 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 655816011790 RHS Repeat; Region: RHS_repeat; pfam05593 655816011791 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 655816011792 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 655816011793 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 655816011794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816011795 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 655816011796 EamA-like transporter family; Region: EamA; pfam00892 655816011797 EamA-like transporter family; Region: EamA; pfam00892 655816011798 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 655816011799 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 655816011800 Ligand Binding Site [chemical binding]; other site 655816011801 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 655816011802 beta-galactosidase; Region: BGL; TIGR03356 655816011803 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 655816011804 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816011805 active site turn [active] 655816011806 phosphorylation site [posttranslational modification] 655816011807 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655816011808 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 655816011809 HPr interaction site; other site 655816011810 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655816011811 active site 655816011812 phosphorylation site [posttranslational modification] 655816011813 LXG domain of WXG superfamily; Region: LXG; pfam04740 655816011814 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 655816011815 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 655816011816 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 655816011817 substrate binding site [chemical binding]; other site 655816011818 active site 655816011819 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816011820 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655816011821 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 655816011822 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 655816011823 hexamer interface [polypeptide binding]; other site 655816011824 RNA binding site [nucleotide binding]; other site 655816011825 Histidine-zinc binding site [chemical binding]; other site 655816011826 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 655816011827 active sites [active] 655816011828 tetramer interface [polypeptide binding]; other site 655816011829 urocanate hydratase; Provisional; Region: PRK05414 655816011830 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 655816011831 imidazolonepropionase; Validated; Region: PRK09356 655816011832 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 655816011833 active site 655816011834 Agmatinase-like family; Region: Agmatinase-like; cd09990 655816011835 agmatinase; Region: agmatinase; TIGR01230 655816011836 active site 655816011837 oligomer interface [polypeptide binding]; other site 655816011838 Mn binding site [ion binding]; other site 655816011839 S-methylmethionine transporter; Provisional; Region: PRK11387 655816011840 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 655816011841 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 655816011842 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 655816011843 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 655816011844 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 655816011845 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 655816011846 Nucleoside recognition; Region: Gate; pfam07670 655816011847 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 655816011848 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 655816011849 intersubunit interface [polypeptide binding]; other site 655816011850 active site 655816011851 catalytic residue [active] 655816011852 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 655816011853 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816011854 DNA binding residues [nucleotide binding] 655816011855 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 655816011856 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 655816011857 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 655816011858 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 655816011859 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 655816011860 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 655816011861 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 655816011862 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 655816011863 metal binding site [ion binding]; metal-binding site 655816011864 dimer interface [polypeptide binding]; other site 655816011865 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 655816011866 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 655816011867 Walker A/P-loop; other site 655816011868 ATP binding site [chemical binding]; other site 655816011869 Q-loop/lid; other site 655816011870 ABC transporter signature motif; other site 655816011871 Walker B; other site 655816011872 D-loop; other site 655816011873 H-loop/switch region; other site 655816011874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816011875 dimer interface [polypeptide binding]; other site 655816011876 conserved gate region; other site 655816011877 putative PBP binding loops; other site 655816011878 ABC-ATPase subunit interface; other site 655816011879 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 655816011880 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655816011881 substrate binding pocket [chemical binding]; other site 655816011882 membrane-bound complex binding site; other site 655816011883 hinge residues; other site 655816011884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816011885 Coenzyme A binding pocket [chemical binding]; other site 655816011886 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 655816011887 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 655816011888 active site 655816011889 non-prolyl cis peptide bond; other site 655816011890 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 655816011891 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 655816011892 active site 655816011893 sugar phosphate phosphatase; Provisional; Region: PRK10513 655816011894 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816011895 active site 655816011896 motif I; other site 655816011897 motif II; other site 655816011898 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816011899 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 655816011900 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 655816011901 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 655816011902 putative ligand binding residues [chemical binding]; other site 655816011903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 655816011904 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816011905 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 655816011906 Walker A/P-loop; other site 655816011907 ATP binding site [chemical binding]; other site 655816011908 Q-loop/lid; other site 655816011909 ABC transporter signature motif; other site 655816011910 Walker B; other site 655816011911 D-loop; other site 655816011912 H-loop/switch region; other site 655816011913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816011914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 655816011915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816011916 ATP binding site [chemical binding]; other site 655816011917 Mg2+ binding site [ion binding]; other site 655816011918 G-X-G motif; other site 655816011919 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816011920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816011921 active site 655816011922 phosphorylation site [posttranslational modification] 655816011923 intermolecular recognition site; other site 655816011924 dimerization interface [polypeptide binding]; other site 655816011925 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816011926 DNA binding site [nucleotide binding] 655816011927 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 655816011928 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 655816011929 intersubunit interface [polypeptide binding]; other site 655816011930 active site 655816011931 zinc binding site [ion binding]; other site 655816011932 Na+ binding site [ion binding]; other site 655816011933 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 655816011934 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 655816011935 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 655816011936 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 655816011937 DNA interaction; other site 655816011938 Metal-binding active site; metal-binding site 655816011939 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816011940 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655816011941 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 655816011942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816011944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011945 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 655816011946 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 655816011947 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 655816011948 PYR/PP interface [polypeptide binding]; other site 655816011949 dimer interface [polypeptide binding]; other site 655816011950 TPP binding site [chemical binding]; other site 655816011951 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 655816011952 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 655816011953 TPP-binding site; other site 655816011954 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655816011955 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 655816011956 substrate binding site [chemical binding]; other site 655816011957 ATP binding site [chemical binding]; other site 655816011958 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 655816011959 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 655816011960 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 655816011961 tetrameric interface [polypeptide binding]; other site 655816011962 NAD binding site [chemical binding]; other site 655816011963 catalytic residues [active] 655816011964 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655816011965 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 655816011966 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655816011967 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816011968 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655816011969 active site 655816011970 catalytic tetrad [active] 655816011971 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 655816011972 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 655816011973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011974 putative substrate translocation pore; other site 655816011975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011976 heat shock protein 90; Provisional; Region: PRK05218 655816011977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816011978 ATP binding site [chemical binding]; other site 655816011979 Mg2+ binding site [ion binding]; other site 655816011980 G-X-G motif; other site 655816011981 short chain dehydrogenase; Validated; Region: PRK08589 655816011982 classical (c) SDRs; Region: SDR_c; cd05233 655816011983 NAD(P) binding site [chemical binding]; other site 655816011984 active site 655816011985 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816011986 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816011987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816011988 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 655816011989 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 655816011990 NAD(P) binding site [chemical binding]; other site 655816011991 catalytic residues [active] 655816011992 RDD family; Region: RDD; pfam06271 655816011993 Predicted membrane protein [Function unknown]; Region: COG2311 655816011994 Protein of unknown function (DUF418); Region: DUF418; pfam04235 655816011995 Cupin domain; Region: Cupin_2; pfam07883 655816011996 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 655816011997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816011998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655816011999 short chain dehydrogenase; Provisional; Region: PRK07109 655816012000 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 655816012001 putative NAD(P) binding site [chemical binding]; other site 655816012002 active site 655816012003 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816012004 MarR family; Region: MarR; pfam01047 655816012005 LrgA family; Region: LrgA; cl00608 655816012006 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 655816012007 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 655816012008 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 655816012009 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 655816012010 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 655816012011 Glycerate kinase family; Region: Gly_kinase; pfam02595 655816012012 Transcriptional regulators [Transcription]; Region: GntR; COG1802 655816012013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816012014 DNA-binding site [nucleotide binding]; DNA binding site 655816012015 FCD domain; Region: FCD; pfam07729 655816012016 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 655816012017 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 655816012018 N- and C-terminal domain interface [polypeptide binding]; other site 655816012019 active site 655816012020 catalytic site [active] 655816012021 metal binding site [ion binding]; metal-binding site 655816012022 carbohydrate binding site [chemical binding]; other site 655816012023 ATP binding site [chemical binding]; other site 655816012024 fructuronate transporter; Provisional; Region: PRK10034; cl15264 655816012025 gluconate transporter; Region: gntP; TIGR00791 655816012026 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 655816012027 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 655816012028 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 655816012029 peroxiredoxin; Region: AhpC; TIGR03137 655816012030 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 655816012031 dimer interface [polypeptide binding]; other site 655816012032 decamer (pentamer of dimers) interface [polypeptide binding]; other site 655816012033 catalytic triad [active] 655816012034 peroxidatic and resolving cysteines [active] 655816012035 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 655816012036 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 655816012037 catalytic residue [active] 655816012038 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 655816012039 catalytic residues [active] 655816012040 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655816012041 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816012042 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 655816012043 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 655816012044 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 655816012045 beta-galactosidase; Region: BGL; TIGR03356 655816012046 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 655816012047 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816012048 active site turn [active] 655816012049 phosphorylation site [posttranslational modification] 655816012050 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655816012051 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 655816012052 HPr interaction site; other site 655816012053 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655816012054 active site 655816012055 phosphorylation site [posttranslational modification] 655816012056 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 655816012057 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816012058 DNA-binding site [nucleotide binding]; DNA binding site 655816012059 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 655816012060 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 655816012061 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 655816012062 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 655816012063 cofactor binding site; other site 655816012064 DNA binding site [nucleotide binding] 655816012065 substrate interaction site [chemical binding]; other site 655816012066 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 655816012067 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 655816012068 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 655816012069 PLD-like domain; Region: PLDc_2; pfam13091 655816012070 putative active site [active] 655816012071 catalytic site [active] 655816012072 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 655816012073 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 655816012074 ATP-binding site [chemical binding]; other site 655816012075 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 655816012076 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 655816012077 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 655816012078 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816012079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816012080 Coenzyme A binding pocket [chemical binding]; other site 655816012081 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816012082 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816012083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816012084 binding surface 655816012085 TPR motif; other site 655816012086 Arginase family; Region: Arginase; cd09989 655816012087 agmatinase; Region: agmatinase; TIGR01230 655816012088 active site 655816012089 Mn binding site [ion binding]; other site 655816012090 oligomer interface [polypeptide binding]; other site 655816012091 S-methylmethionine transporter; Provisional; Region: PRK11387 655816012092 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 655816012093 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816012094 inhibitor-cofactor binding pocket; inhibition site 655816012095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816012096 catalytic residue [active] 655816012097 PAS domain; Region: PAS; smart00091 655816012098 PAS domain; Region: PAS_9; pfam13426 655816012099 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 655816012100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816012101 Walker A motif; other site 655816012102 ATP binding site [chemical binding]; other site 655816012103 Walker B motif; other site 655816012104 arginine finger; other site 655816012105 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 655816012106 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 655816012107 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 655816012108 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655816012109 protein binding site [polypeptide binding]; other site 655816012110 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 655816012111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 655816012112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 655816012113 YycH protein; Region: YycH; pfam07435 655816012114 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 655816012115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816012116 dimerization interface [polypeptide binding]; other site 655816012117 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816012118 putative active site [active] 655816012119 heme pocket [chemical binding]; other site 655816012120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816012121 dimer interface [polypeptide binding]; other site 655816012122 phosphorylation site [posttranslational modification] 655816012123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816012124 ATP binding site [chemical binding]; other site 655816012125 Mg2+ binding site [ion binding]; other site 655816012126 G-X-G motif; other site 655816012127 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816012128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816012129 active site 655816012130 phosphorylation site [posttranslational modification] 655816012131 intermolecular recognition site; other site 655816012132 dimerization interface [polypeptide binding]; other site 655816012133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816012134 DNA binding site [nucleotide binding] 655816012135 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 655816012136 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 655816012137 GDP-binding site [chemical binding]; other site 655816012138 ACT binding site; other site 655816012139 IMP binding site; other site 655816012140 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816012141 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 655816012142 active site 655816012143 replicative DNA helicase; Provisional; Region: PRK05748 655816012144 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 655816012145 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 655816012146 Walker A motif; other site 655816012147 ATP binding site [chemical binding]; other site 655816012148 Walker B motif; other site 655816012149 DNA binding loops [nucleotide binding] 655816012150 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 655816012151 YycC-like protein; Region: YycC; pfam14174 655816012152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816012153 cyanate transporter; Region: CynX; TIGR00896 655816012154 putative substrate translocation pore; other site 655816012155 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 655816012156 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 655816012157 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 655816012158 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 655816012159 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 655816012160 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 655816012161 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 655816012162 DHH family; Region: DHH; pfam01368 655816012163 DHHA1 domain; Region: DHHA1; pfam02272 655816012164 Predicted membrane protein [Function unknown]; Region: COG4241 655816012165 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 655816012166 Predicted transcriptional regulators [Transcription]; Region: COG1733 655816012167 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 655816012168 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 655816012169 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 655816012170 DHHA2 domain; Region: DHHA2; pfam02833 655816012171 ANTAR domain; Region: ANTAR; cl04297 655816012172 D-galactonate transporter; Region: 2A0114; TIGR00893 655816012173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816012174 putative substrate translocation pore; other site 655816012175 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 655816012176 DNA binding residues [nucleotide binding] 655816012177 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 655816012178 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 655816012179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816012180 putative substrate translocation pore; other site 655816012181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816012182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655816012183 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 655816012184 putative dimerization interface [polypeptide binding]; other site 655816012185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816012186 Coenzyme A binding pocket [chemical binding]; other site 655816012187 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 655816012188 Predicted transcriptional regulators [Transcription]; Region: COG1733 655816012189 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 655816012190 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 655816012191 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816012192 MarR family; Region: MarR; pfam01047 655816012193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816012194 Coenzyme A binding pocket [chemical binding]; other site 655816012195 Predicted membrane protein [Function unknown]; Region: COG2364 655816012196 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 655816012197 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 655816012198 catalytic residues [active] 655816012199 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 655816012200 CAAX protease self-immunity; Region: Abi; pfam02517 655816012201 benzoate transport; Region: 2A0115; TIGR00895 655816012202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816012203 putative substrate translocation pore; other site 655816012204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816012205 maltose O-acetyltransferase; Provisional; Region: PRK10092 655816012206 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 655816012207 active site 655816012208 substrate binding site [chemical binding]; other site 655816012209 trimer interface [polypeptide binding]; other site 655816012210 CoA binding site [chemical binding]; other site 655816012211 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 655816012212 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816012213 putative metal binding site [ion binding]; other site 655816012214 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816012215 DNA binding site [nucleotide binding] 655816012216 domain linker motif; other site 655816012217 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 655816012218 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 655816012219 putative dimerization interface [polypeptide binding]; other site 655816012220 putative ligand binding site [chemical binding]; other site 655816012221 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 655816012222 active site 655816012223 putative catalytic site [active] 655816012224 DNA binding site [nucleotide binding] 655816012225 putative phosphate binding site [ion binding]; other site 655816012226 metal binding site A [ion binding]; metal-binding site 655816012227 AP binding site [nucleotide binding]; other site 655816012228 metal binding site B [ion binding]; metal-binding site 655816012229 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 655816012230 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 655816012231 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 655816012232 dimer interface [polypeptide binding]; other site 655816012233 ssDNA binding site [nucleotide binding]; other site 655816012234 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816012235 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 655816012236 GTP-binding protein YchF; Reviewed; Region: PRK09601 655816012237 YchF GTPase; Region: YchF; cd01900 655816012238 G1 box; other site 655816012239 GTP/Mg2+ binding site [chemical binding]; other site 655816012240 Switch I region; other site 655816012241 G2 box; other site 655816012242 Switch II region; other site 655816012243 G3 box; other site 655816012244 G4 box; other site 655816012245 G5 box; other site 655816012246 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 655816012247 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 655816012248 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 655816012249 putative [4Fe-4S] binding site [ion binding]; other site 655816012250 putative molybdopterin cofactor binding site [chemical binding]; other site 655816012251 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 655816012252 molybdopterin cofactor binding site; other site 655816012253 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 655816012254 Uncharacterized membrane protein [Function unknown]; Region: COG3949 655816012255 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 655816012256 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 655816012257 ParB-like nuclease domain; Region: ParB; smart00470 655816012258 KorB domain; Region: KorB; pfam08535 655816012259 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 655816012260 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 655816012261 P-loop; other site 655816012262 Magnesium ion binding site [ion binding]; other site 655816012263 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 655816012264 Magnesium ion binding site [ion binding]; other site 655816012265 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 655816012266 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 655816012267 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 655816012268 ParB-like nuclease domain; Region: ParB; smart00470 655816012269 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 655816012270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816012271 S-adenosylmethionine binding site [chemical binding]; other site 655816012272 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 655816012273 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 655816012274 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 655816012275 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 655816012276 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 655816012277 trmE is a tRNA modification GTPase; Region: trmE; cd04164 655816012278 G1 box; other site 655816012279 GTP/Mg2+ binding site [chemical binding]; other site 655816012280 Switch I region; other site 655816012281 G2 box; other site 655816012282 Switch II region; other site 655816012283 G3 box; other site 655816012284 G4 box; other site 655816012285 G5 box; other site 655816012286 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 655816012287 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 655816012288 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 655816012289 G-X-X-G motif; other site 655816012290 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 655816012291 RxxxH motif; other site 655816012292 OxaA-like protein precursor; Validated; Region: PRK02944 655816012293 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 655816012294 ribonuclease P; Reviewed; Region: rnpA; PRK00499 655816012295 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399