-- dump date 20140618_225800 -- class Genbank::misc_feature -- table misc_feature_note -- id note 714359000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 714359000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 714359000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359000004 Walker A motif; other site 714359000005 ATP binding site [chemical binding]; other site 714359000006 Walker B motif; other site 714359000007 arginine finger; other site 714359000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 714359000009 DnaA box-binding interface [nucleotide binding]; other site 714359000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 714359000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 714359000012 putative DNA binding surface [nucleotide binding]; other site 714359000013 dimer interface [polypeptide binding]; other site 714359000014 beta-clamp/clamp loader binding surface; other site 714359000015 beta-clamp/translesion DNA polymerase binding surface; other site 714359000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 714359000017 recombination protein F; Reviewed; Region: recF; PRK00064 714359000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 714359000019 Walker A/P-loop; other site 714359000020 ATP binding site [chemical binding]; other site 714359000021 Q-loop/lid; other site 714359000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359000023 ABC transporter signature motif; other site 714359000024 Walker B; other site 714359000025 D-loop; other site 714359000026 H-loop/switch region; other site 714359000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 714359000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359000029 Mg2+ binding site [ion binding]; other site 714359000030 G-X-G motif; other site 714359000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 714359000032 anchoring element; other site 714359000033 dimer interface [polypeptide binding]; other site 714359000034 ATP binding site [chemical binding]; other site 714359000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 714359000036 active site 714359000037 putative metal-binding site [ion binding]; other site 714359000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 714359000039 DNA gyrase subunit A; Validated; Region: PRK05560 714359000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 714359000041 CAP-like domain; other site 714359000042 active site 714359000043 primary dimer interface [polypeptide binding]; other site 714359000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359000050 YaaC-like Protein; Region: YaaC; pfam14175 714359000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 714359000052 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 714359000053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 714359000054 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 714359000055 active site 714359000056 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359000057 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714359000058 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 714359000059 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 714359000060 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 714359000061 active site 714359000062 multimer interface [polypeptide binding]; other site 714359000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 714359000064 predicted active site [active] 714359000065 catalytic triad [active] 714359000066 seryl-tRNA synthetase; Provisional; Region: PRK05431 714359000067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 714359000068 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 714359000069 dimer interface [polypeptide binding]; other site 714359000070 active site 714359000071 motif 1; other site 714359000072 motif 2; other site 714359000073 motif 3; other site 714359000074 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 714359000075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359000076 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 714359000077 DNA binding residues [nucleotide binding] 714359000078 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 714359000079 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 714359000080 Substrate-binding site [chemical binding]; other site 714359000081 Substrate specificity [chemical binding]; other site 714359000082 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 714359000083 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 714359000084 Substrate-binding site [chemical binding]; other site 714359000085 Substrate specificity [chemical binding]; other site 714359000086 Isochorismatase family; Region: Isochorismatase; pfam00857 714359000087 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 714359000088 catalytic triad [active] 714359000089 conserved cis-peptide bond; other site 714359000090 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 714359000091 nucleoside/Zn binding site; other site 714359000092 dimer interface [polypeptide binding]; other site 714359000093 catalytic motif [active] 714359000094 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 714359000095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359000096 Walker A motif; other site 714359000097 ATP binding site [chemical binding]; other site 714359000098 Walker B motif; other site 714359000099 arginine finger; other site 714359000100 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 714359000101 hypothetical protein; Validated; Region: PRK00153 714359000102 recombination protein RecR; Reviewed; Region: recR; PRK00076 714359000103 RecR protein; Region: RecR; pfam02132 714359000104 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 714359000105 putative active site [active] 714359000106 putative metal-binding site [ion binding]; other site 714359000107 tetramer interface [polypeptide binding]; other site 714359000108 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 714359000109 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 714359000110 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 714359000111 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 714359000112 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 714359000113 homodimer interface [polypeptide binding]; other site 714359000114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359000115 catalytic residue [active] 714359000116 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 714359000117 thymidylate kinase; Validated; Region: tmk; PRK00698 714359000118 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 714359000119 TMP-binding site; other site 714359000120 ATP-binding site [chemical binding]; other site 714359000121 DNA polymerase III subunit delta'; Validated; Region: PRK08058 714359000122 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 714359000123 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 714359000124 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 714359000125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359000126 S-adenosylmethionine binding site [chemical binding]; other site 714359000127 Predicted methyltransferases [General function prediction only]; Region: COG0313 714359000128 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 714359000129 putative SAM binding site [chemical binding]; other site 714359000130 putative homodimer interface [polypeptide binding]; other site 714359000131 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 714359000132 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 714359000133 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 714359000134 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 714359000135 active site 714359000136 HIGH motif; other site 714359000137 KMSKS motif; other site 714359000138 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 714359000139 tRNA binding surface [nucleotide binding]; other site 714359000140 anticodon binding site; other site 714359000141 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 714359000142 dimer interface [polypeptide binding]; other site 714359000143 putative tRNA-binding site [nucleotide binding]; other site 714359000144 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 714359000145 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 714359000146 active site 714359000147 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 714359000148 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 714359000149 putative active site [active] 714359000150 putative metal binding site [ion binding]; other site 714359000151 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 714359000152 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 714359000153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359000154 S-adenosylmethionine binding site [chemical binding]; other site 714359000155 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 714359000156 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 714359000157 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359000158 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 714359000159 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 714359000160 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 714359000161 pur operon repressor; Provisional; Region: PRK09213 714359000162 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 714359000163 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714359000164 active site 714359000165 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 714359000166 homotrimer interaction site [polypeptide binding]; other site 714359000167 putative active site [active] 714359000168 regulatory protein SpoVG; Reviewed; Region: PRK13259 714359000169 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 714359000170 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 714359000171 Substrate binding site; other site 714359000172 Mg++ binding site; other site 714359000173 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 714359000174 active site 714359000175 substrate binding site [chemical binding]; other site 714359000176 CoA binding site [chemical binding]; other site 714359000177 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 714359000178 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 714359000179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714359000180 active site 714359000181 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 714359000182 putative active site [active] 714359000183 catalytic residue [active] 714359000184 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 714359000185 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 714359000186 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 714359000187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359000188 ATP binding site [chemical binding]; other site 714359000189 putative Mg++ binding site [ion binding]; other site 714359000190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359000191 nucleotide binding region [chemical binding]; other site 714359000192 ATP-binding site [chemical binding]; other site 714359000193 TRCF domain; Region: TRCF; pfam03461 714359000194 stage V sporulation protein T; Region: spore_V_T; TIGR02851 714359000195 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 714359000196 stage V sporulation protein B; Region: spore_V_B; TIGR02900 714359000197 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 714359000198 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 714359000199 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 714359000200 putative SAM binding site [chemical binding]; other site 714359000201 putative homodimer interface [polypeptide binding]; other site 714359000202 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 714359000203 homodimer interface [polypeptide binding]; other site 714359000204 metal binding site [ion binding]; metal-binding site 714359000205 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 714359000206 homodimer interface [polypeptide binding]; other site 714359000207 active site 714359000208 putative chemical substrate binding site [chemical binding]; other site 714359000209 metal binding site [ion binding]; metal-binding site 714359000210 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359000211 RNA binding surface [nucleotide binding]; other site 714359000212 YabP family; Region: YabP; cl06766 714359000213 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 714359000214 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 714359000215 Septum formation initiator; Region: DivIC; pfam04977 714359000216 hypothetical protein; Provisional; Region: PRK08582 714359000217 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 714359000218 RNA binding site [nucleotide binding]; other site 714359000219 stage II sporulation protein E; Region: spore_II_E; TIGR02865 714359000220 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 714359000221 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 714359000222 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 714359000223 Ligand Binding Site [chemical binding]; other site 714359000224 TilS substrate binding domain; Region: TilS; pfam09179 714359000225 TilS substrate C-terminal domain; Region: TilS_C; smart00977 714359000226 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714359000227 active site 714359000228 FtsH Extracellular; Region: FtsH_ext; pfam06480 714359000229 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 714359000230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359000231 Walker A motif; other site 714359000232 ATP binding site [chemical binding]; other site 714359000233 Walker B motif; other site 714359000234 arginine finger; other site 714359000235 Peptidase family M41; Region: Peptidase_M41; pfam01434 714359000236 pantothenate kinase; Reviewed; Region: PRK13318 714359000237 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 714359000238 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 714359000239 dimerization interface [polypeptide binding]; other site 714359000240 domain crossover interface; other site 714359000241 redox-dependent activation switch; other site 714359000242 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 714359000243 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 714359000244 dimer interface [polypeptide binding]; other site 714359000245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359000246 catalytic residue [active] 714359000247 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 714359000248 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 714359000249 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 714359000250 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 714359000251 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 714359000252 glutamine binding [chemical binding]; other site 714359000253 catalytic triad [active] 714359000254 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 714359000255 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 714359000256 homodimer interface [polypeptide binding]; other site 714359000257 substrate-cofactor binding pocket; other site 714359000258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359000259 catalytic residue [active] 714359000260 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 714359000261 dihydropteroate synthase; Region: DHPS; TIGR01496 714359000262 substrate binding pocket [chemical binding]; other site 714359000263 dimer interface [polypeptide binding]; other site 714359000264 inhibitor binding site; inhibition site 714359000265 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 714359000266 homooctamer interface [polypeptide binding]; other site 714359000267 active site 714359000268 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 714359000269 catalytic center binding site [active] 714359000270 ATP binding site [chemical binding]; other site 714359000271 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359000272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359000273 non-specific DNA binding site [nucleotide binding]; other site 714359000274 salt bridge; other site 714359000275 sequence-specific DNA binding site [nucleotide binding]; other site 714359000276 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 714359000277 phosphate binding site [ion binding]; other site 714359000278 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 714359000279 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 714359000280 dimer interface [polypeptide binding]; other site 714359000281 putative anticodon binding site; other site 714359000282 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 714359000283 motif 1; other site 714359000284 active site 714359000285 motif 2; other site 714359000286 motif 3; other site 714359000287 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 714359000288 UvrB/uvrC motif; Region: UVR; pfam02151 714359000289 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 714359000290 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 714359000291 ADP binding site [chemical binding]; other site 714359000292 phosphagen binding site; other site 714359000293 substrate specificity loop; other site 714359000294 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 714359000295 Clp amino terminal domain; Region: Clp_N; pfam02861 714359000296 Clp amino terminal domain; Region: Clp_N; pfam02861 714359000297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359000298 Walker A motif; other site 714359000299 ATP binding site [chemical binding]; other site 714359000300 Walker B motif; other site 714359000301 arginine finger; other site 714359000302 UvrB/uvrC motif; Region: UVR; pfam02151 714359000303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359000304 Walker A motif; other site 714359000305 ATP binding site [chemical binding]; other site 714359000306 Walker B motif; other site 714359000307 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 714359000308 DNA repair protein RadA; Provisional; Region: PRK11823 714359000309 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 714359000310 Walker A motif/ATP binding site; other site 714359000311 ATP binding site [chemical binding]; other site 714359000312 Walker B motif; other site 714359000313 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 714359000314 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 714359000315 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 714359000316 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 714359000317 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 714359000318 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 714359000319 putative active site [active] 714359000320 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 714359000321 substrate binding site; other site 714359000322 dimer interface; other site 714359000323 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 714359000324 homotrimer interaction site [polypeptide binding]; other site 714359000325 zinc binding site [ion binding]; other site 714359000326 CDP-binding sites; other site 714359000327 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 714359000328 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 714359000329 active site 714359000330 HIGH motif; other site 714359000331 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 714359000332 active site 714359000333 KMSKS motif; other site 714359000334 serine O-acetyltransferase; Region: cysE; TIGR01172 714359000335 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 714359000336 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 714359000337 trimer interface [polypeptide binding]; other site 714359000338 active site 714359000339 substrate binding site [chemical binding]; other site 714359000340 CoA binding site [chemical binding]; other site 714359000341 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 714359000342 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 714359000343 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 714359000344 KMSKS motif; other site 714359000345 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 714359000346 tRNA binding surface [nucleotide binding]; other site 714359000347 anticodon binding site; other site 714359000348 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 714359000349 active site 714359000350 metal binding site [ion binding]; metal-binding site 714359000351 dimerization interface [polypeptide binding]; other site 714359000352 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 714359000353 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 714359000354 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 714359000355 YacP-like NYN domain; Region: NYN_YacP; pfam05991 714359000356 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 714359000357 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359000358 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 714359000359 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 714359000360 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 714359000361 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 714359000362 putative homodimer interface [polypeptide binding]; other site 714359000363 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 714359000364 heterodimer interface [polypeptide binding]; other site 714359000365 homodimer interface [polypeptide binding]; other site 714359000366 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 714359000367 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 714359000368 23S rRNA interface [nucleotide binding]; other site 714359000369 L7/L12 interface [polypeptide binding]; other site 714359000370 putative thiostrepton binding site; other site 714359000371 L25 interface [polypeptide binding]; other site 714359000372 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 714359000373 mRNA/rRNA interface [nucleotide binding]; other site 714359000374 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 714359000375 23S rRNA interface [nucleotide binding]; other site 714359000376 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 714359000377 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 714359000378 core dimer interface [polypeptide binding]; other site 714359000379 peripheral dimer interface [polypeptide binding]; other site 714359000380 L10 interface [polypeptide binding]; other site 714359000381 L11 interface [polypeptide binding]; other site 714359000382 putative EF-Tu interaction site [polypeptide binding]; other site 714359000383 putative EF-G interaction site [polypeptide binding]; other site 714359000384 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 714359000385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359000386 S-adenosylmethionine binding site [chemical binding]; other site 714359000387 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 714359000388 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 714359000389 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 714359000390 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 714359000391 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 714359000392 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 714359000393 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 714359000394 RPB10 interaction site [polypeptide binding]; other site 714359000395 RPB1 interaction site [polypeptide binding]; other site 714359000396 RPB11 interaction site [polypeptide binding]; other site 714359000397 RPB3 interaction site [polypeptide binding]; other site 714359000398 RPB12 interaction site [polypeptide binding]; other site 714359000399 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 714359000400 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 714359000401 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 714359000402 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 714359000403 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 714359000404 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 714359000405 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 714359000406 G-loop; other site 714359000407 DNA binding site [nucleotide binding] 714359000408 hypothetical protein; Provisional; Region: PRK06683 714359000409 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 714359000410 S17 interaction site [polypeptide binding]; other site 714359000411 S8 interaction site; other site 714359000412 16S rRNA interaction site [nucleotide binding]; other site 714359000413 streptomycin interaction site [chemical binding]; other site 714359000414 23S rRNA interaction site [nucleotide binding]; other site 714359000415 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 714359000416 30S ribosomal protein S7; Validated; Region: PRK05302 714359000417 elongation factor G; Reviewed; Region: PRK00007 714359000418 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 714359000419 G1 box; other site 714359000420 putative GEF interaction site [polypeptide binding]; other site 714359000421 GTP/Mg2+ binding site [chemical binding]; other site 714359000422 Switch I region; other site 714359000423 G2 box; other site 714359000424 G3 box; other site 714359000425 Switch II region; other site 714359000426 G4 box; other site 714359000427 G5 box; other site 714359000428 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 714359000429 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 714359000430 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 714359000431 elongation factor Tu; Reviewed; Region: PRK00049 714359000432 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 714359000433 G1 box; other site 714359000434 GEF interaction site [polypeptide binding]; other site 714359000435 GTP/Mg2+ binding site [chemical binding]; other site 714359000436 Switch I region; other site 714359000437 G2 box; other site 714359000438 G3 box; other site 714359000439 Switch II region; other site 714359000440 G4 box; other site 714359000441 G5 box; other site 714359000442 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 714359000443 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 714359000444 Antibiotic Binding Site [chemical binding]; other site 714359000445 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 714359000446 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 714359000447 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 714359000448 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 714359000449 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 714359000450 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 714359000451 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 714359000452 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 714359000453 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 714359000454 putative translocon binding site; other site 714359000455 protein-rRNA interface [nucleotide binding]; other site 714359000456 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 714359000457 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 714359000458 G-X-X-G motif; other site 714359000459 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 714359000460 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 714359000461 23S rRNA interface [nucleotide binding]; other site 714359000462 5S rRNA interface [nucleotide binding]; other site 714359000463 putative antibiotic binding site [chemical binding]; other site 714359000464 L25 interface [polypeptide binding]; other site 714359000465 L27 interface [polypeptide binding]; other site 714359000466 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 714359000467 23S rRNA interface [nucleotide binding]; other site 714359000468 putative translocon interaction site; other site 714359000469 signal recognition particle (SRP54) interaction site; other site 714359000470 L23 interface [polypeptide binding]; other site 714359000471 trigger factor interaction site; other site 714359000472 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 714359000473 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 714359000474 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 714359000475 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 714359000476 RNA binding site [nucleotide binding]; other site 714359000477 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 714359000478 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 714359000479 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 714359000480 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 714359000481 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 714359000482 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 714359000483 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 714359000484 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 714359000485 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 714359000486 5S rRNA interface [nucleotide binding]; other site 714359000487 L27 interface [polypeptide binding]; other site 714359000488 23S rRNA interface [nucleotide binding]; other site 714359000489 L5 interface [polypeptide binding]; other site 714359000490 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 714359000491 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 714359000492 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 714359000493 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 714359000494 23S rRNA binding site [nucleotide binding]; other site 714359000495 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 714359000496 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 714359000497 SecY translocase; Region: SecY; pfam00344 714359000498 adenylate kinase; Reviewed; Region: adk; PRK00279 714359000499 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 714359000500 AMP-binding site [chemical binding]; other site 714359000501 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 714359000502 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 714359000503 active site 714359000504 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 714359000505 rRNA binding site [nucleotide binding]; other site 714359000506 predicted 30S ribosome binding site; other site 714359000507 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 714359000508 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 714359000509 30S ribosomal protein S13; Region: bact_S13; TIGR03631 714359000510 30S ribosomal protein S11; Validated; Region: PRK05309 714359000511 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 714359000512 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 714359000513 alphaNTD - beta interaction site [polypeptide binding]; other site 714359000514 alphaNTD homodimer interface [polypeptide binding]; other site 714359000515 alphaNTD - beta' interaction site [polypeptide binding]; other site 714359000516 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 714359000517 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 714359000518 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 714359000519 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 714359000520 Walker A/P-loop; other site 714359000521 ATP binding site [chemical binding]; other site 714359000522 Q-loop/lid; other site 714359000523 ABC transporter signature motif; other site 714359000524 Walker B; other site 714359000525 D-loop; other site 714359000526 H-loop/switch region; other site 714359000527 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 714359000528 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 714359000529 Walker A/P-loop; other site 714359000530 ATP binding site [chemical binding]; other site 714359000531 Q-loop/lid; other site 714359000532 ABC transporter signature motif; other site 714359000533 Walker B; other site 714359000534 D-loop; other site 714359000535 H-loop/switch region; other site 714359000536 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 714359000537 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 714359000538 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 714359000539 dimerization interface 3.5A [polypeptide binding]; other site 714359000540 active site 714359000541 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 714359000542 23S rRNA interface [nucleotide binding]; other site 714359000543 L3 interface [polypeptide binding]; other site 714359000544 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 714359000545 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 714359000546 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 714359000547 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714359000548 active site 714359000549 metal binding site [ion binding]; metal-binding site 714359000550 Domain of unknown function DUF59; Region: DUF59; cl00941 714359000551 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 714359000552 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 714359000553 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 714359000554 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 714359000555 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 714359000556 NodB motif; other site 714359000557 putative active site [active] 714359000558 putative catalytic site [active] 714359000559 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 714359000560 Arginase family; Region: Arginase; cd09989 714359000561 agmatinase; Region: agmatinase; TIGR01230 714359000562 active site 714359000563 Mn binding site [ion binding]; other site 714359000564 oligomer interface [polypeptide binding]; other site 714359000565 Uncharacterized conserved protein [Function unknown]; Region: COG1624 714359000566 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 714359000567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 714359000568 YbbR-like protein; Region: YbbR; pfam07949 714359000569 YbbR-like protein; Region: YbbR; pfam07949 714359000570 YbbR-like protein; Region: YbbR; pfam07949 714359000571 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 714359000572 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 714359000573 active site 714359000574 substrate binding site [chemical binding]; other site 714359000575 metal binding site [ion binding]; metal-binding site 714359000576 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 714359000577 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 714359000578 glutaminase active site [active] 714359000579 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 714359000580 dimer interface [polypeptide binding]; other site 714359000581 active site 714359000582 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 714359000583 dimer interface [polypeptide binding]; other site 714359000584 active site 714359000585 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 714359000586 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 714359000587 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 714359000588 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 714359000589 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 714359000590 Predicted membrane protein [Function unknown]; Region: COG2259 714359000591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359000592 classical (c) SDRs; Region: SDR_c; cd05233 714359000593 NAD(P) binding site [chemical binding]; other site 714359000594 active site 714359000595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359000596 ABC-ATPase subunit interface; other site 714359000597 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 714359000598 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 714359000599 Walker A/P-loop; other site 714359000600 ATP binding site [chemical binding]; other site 714359000601 Q-loop/lid; other site 714359000602 ABC transporter signature motif; other site 714359000603 Walker B; other site 714359000604 D-loop; other site 714359000605 H-loop/switch region; other site 714359000606 NIL domain; Region: NIL; pfam09383 714359000607 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 714359000608 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 714359000609 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714359000610 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 714359000611 putative NAD(P) binding site [chemical binding]; other site 714359000612 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 714359000613 FAD binding domain; Region: FAD_binding_4; pfam01565 714359000614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359000615 putative substrate translocation pore; other site 714359000616 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 714359000617 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 714359000618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359000619 putative substrate translocation pore; other site 714359000620 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 714359000621 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 714359000622 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 714359000623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359000624 dimer interface [polypeptide binding]; other site 714359000625 conserved gate region; other site 714359000626 putative PBP binding loops; other site 714359000627 ABC-ATPase subunit interface; other site 714359000628 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 714359000629 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 714359000630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359000631 dimer interface [polypeptide binding]; other site 714359000632 conserved gate region; other site 714359000633 putative PBP binding loops; other site 714359000634 ABC-ATPase subunit interface; other site 714359000635 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 714359000636 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714359000637 Walker A/P-loop; other site 714359000638 ATP binding site [chemical binding]; other site 714359000639 Q-loop/lid; other site 714359000640 ABC transporter signature motif; other site 714359000641 Walker B; other site 714359000642 D-loop; other site 714359000643 H-loop/switch region; other site 714359000644 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714359000645 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 714359000646 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714359000647 Walker A/P-loop; other site 714359000648 ATP binding site [chemical binding]; other site 714359000649 Q-loop/lid; other site 714359000650 ABC transporter signature motif; other site 714359000651 Walker B; other site 714359000652 D-loop; other site 714359000653 H-loop/switch region; other site 714359000654 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 714359000655 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359000656 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359000657 peptide binding site [polypeptide binding]; other site 714359000658 YusW-like protein; Region: YusW; pfam14039 714359000659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359000660 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714359000661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359000662 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359000663 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359000664 peptide binding site [polypeptide binding]; other site 714359000665 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359000666 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359000667 peptide binding site [polypeptide binding]; other site 714359000668 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359000669 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714359000670 active site 714359000671 catalytic tetrad [active] 714359000672 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 714359000673 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 714359000674 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 714359000675 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 714359000676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359000677 dimer interface [polypeptide binding]; other site 714359000678 conserved gate region; other site 714359000679 putative PBP binding loops; other site 714359000680 ABC-ATPase subunit interface; other site 714359000681 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 714359000682 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359000683 dimerization interface [polypeptide binding]; other site 714359000684 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359000685 membrane-bound complex binding site; other site 714359000686 hinge residues; other site 714359000687 DNA binding domain, excisionase family; Region: excise; TIGR01764 714359000688 PBP superfamily domain; Region: PBP_like; pfam12727 714359000689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359000690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359000691 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 714359000692 putative dimerization interface [polypeptide binding]; other site 714359000693 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714359000694 EamA-like transporter family; Region: EamA; pfam00892 714359000695 YrzO-like protein; Region: YrzO; pfam14142 714359000696 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 714359000697 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 714359000698 putative acyl-acceptor binding pocket; other site 714359000699 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359000700 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359000701 DNA binding site [nucleotide binding] 714359000702 domain linker motif; other site 714359000703 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 714359000704 putative ligand binding site [chemical binding]; other site 714359000705 putative dimerization interface [polypeptide binding]; other site 714359000706 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359000707 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359000708 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359000709 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 714359000710 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 714359000711 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 714359000712 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 714359000713 active site 714359000714 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 714359000715 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 714359000716 NodB motif; other site 714359000717 putative active site [active] 714359000718 putative catalytic site [active] 714359000719 putative Zn binding site [ion binding]; other site 714359000720 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 714359000721 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714359000722 catalytic residue [active] 714359000723 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 714359000724 nucleotide binding site/active site [active] 714359000725 HIT family signature motif; other site 714359000726 catalytic residue [active] 714359000727 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359000728 ABC transporter; Region: ABC_tran_2; pfam12848 714359000729 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359000730 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359000731 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 714359000732 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 714359000733 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 714359000734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359000735 dimer interface [polypeptide binding]; other site 714359000736 conserved gate region; other site 714359000737 putative PBP binding loops; other site 714359000738 ABC-ATPase subunit interface; other site 714359000739 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 714359000740 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 714359000741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359000742 dimer interface [polypeptide binding]; other site 714359000743 conserved gate region; other site 714359000744 putative PBP binding loops; other site 714359000745 ABC-ATPase subunit interface; other site 714359000746 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 714359000747 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714359000748 Walker A/P-loop; other site 714359000749 ATP binding site [chemical binding]; other site 714359000750 Q-loop/lid; other site 714359000751 ABC transporter signature motif; other site 714359000752 Walker B; other site 714359000753 D-loop; other site 714359000754 H-loop/switch region; other site 714359000755 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 714359000756 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 714359000757 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714359000758 Walker A/P-loop; other site 714359000759 ATP binding site [chemical binding]; other site 714359000760 Q-loop/lid; other site 714359000761 ABC transporter signature motif; other site 714359000762 Walker B; other site 714359000763 D-loop; other site 714359000764 H-loop/switch region; other site 714359000765 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 714359000766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359000767 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359000768 active site 714359000769 motif I; other site 714359000770 motif II; other site 714359000771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359000772 motif II; other site 714359000773 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 714359000774 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 714359000775 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 714359000776 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 714359000777 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 714359000778 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 714359000779 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 714359000780 dimer interface [polypeptide binding]; other site 714359000781 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 714359000782 active site 714359000783 Fe binding site [ion binding]; other site 714359000784 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 714359000785 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 714359000786 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 714359000787 amino acid transporter; Region: 2A0306; TIGR00909 714359000788 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 714359000789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359000790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359000791 putative substrate translocation pore; other site 714359000792 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 714359000793 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 714359000794 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 714359000795 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 714359000796 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 714359000797 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714359000798 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714359000799 helicase 45; Provisional; Region: PTZ00424 714359000800 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714359000801 ATP binding site [chemical binding]; other site 714359000802 Mg++ binding site [ion binding]; other site 714359000803 motif III; other site 714359000804 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359000805 nucleotide binding region [chemical binding]; other site 714359000806 ATP-binding site [chemical binding]; other site 714359000807 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 714359000808 Rhomboid family; Region: Rhomboid; pfam01694 714359000809 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 714359000810 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 714359000811 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 714359000812 alanine racemase; Reviewed; Region: alr; PRK00053 714359000813 active site 714359000814 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714359000815 dimer interface [polypeptide binding]; other site 714359000816 substrate binding site [chemical binding]; other site 714359000817 catalytic residues [active] 714359000818 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 714359000819 PemK-like protein; Region: PemK; pfam02452 714359000820 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 714359000821 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 714359000822 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 714359000823 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 714359000824 RNA binding site [nucleotide binding]; other site 714359000825 hypothetical protein; Provisional; Region: PRK04351 714359000826 SprT homologues; Region: SprT; cl01182 714359000827 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 714359000828 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 714359000829 Glycoprotease family; Region: Peptidase_M22; pfam00814 714359000830 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 714359000831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359000832 Coenzyme A binding pocket [chemical binding]; other site 714359000833 UGMP family protein; Validated; Region: PRK09604 714359000834 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 714359000835 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 714359000836 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359000837 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359000838 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359000839 ABC transporter; Region: ABC_tran_2; pfam12848 714359000840 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359000841 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 714359000842 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 714359000843 CoA binding domain; Region: CoA_binding; pfam02629 714359000844 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 714359000845 CAAX protease self-immunity; Region: Abi; pfam02517 714359000846 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 714359000847 oligomerisation interface [polypeptide binding]; other site 714359000848 mobile loop; other site 714359000849 roof hairpin; other site 714359000850 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 714359000851 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 714359000852 ring oligomerisation interface [polypeptide binding]; other site 714359000853 ATP/Mg binding site [chemical binding]; other site 714359000854 stacking interactions; other site 714359000855 hinge regions; other site 714359000856 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 714359000857 putative active site [active] 714359000858 putative NTP binding site [chemical binding]; other site 714359000859 putative nucleic acid binding site [nucleotide binding]; other site 714359000860 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 714359000861 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 714359000862 putative active site [active] 714359000863 putative NTP binding site [chemical binding]; other site 714359000864 putative nucleic acid binding site [nucleotide binding]; other site 714359000865 GMP synthase; Reviewed; Region: guaA; PRK00074 714359000866 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 714359000867 AMP/PPi binding site [chemical binding]; other site 714359000868 candidate oxyanion hole; other site 714359000869 catalytic triad [active] 714359000870 potential glutamine specificity residues [chemical binding]; other site 714359000871 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 714359000872 ATP Binding subdomain [chemical binding]; other site 714359000873 Ligand Binding sites [chemical binding]; other site 714359000874 Dimerization subdomain; other site 714359000875 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 714359000876 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359000877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359000878 active site 714359000879 phosphorylation site [posttranslational modification] 714359000880 intermolecular recognition site; other site 714359000881 dimerization interface [polypeptide binding]; other site 714359000882 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359000883 DNA binding site [nucleotide binding] 714359000884 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359000885 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359000886 dimerization interface [polypeptide binding]; other site 714359000887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359000888 dimer interface [polypeptide binding]; other site 714359000889 phosphorylation site [posttranslational modification] 714359000890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359000891 ATP binding site [chemical binding]; other site 714359000892 Mg2+ binding site [ion binding]; other site 714359000893 G-X-G motif; other site 714359000894 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 714359000895 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359000896 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 714359000897 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 714359000898 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 714359000899 catalytic residues [active] 714359000900 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 714359000901 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 714359000902 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 714359000903 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359000904 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 714359000905 Walker A/P-loop; other site 714359000906 ATP binding site [chemical binding]; other site 714359000907 Q-loop/lid; other site 714359000908 ABC transporter signature motif; other site 714359000909 Walker B; other site 714359000910 D-loop; other site 714359000911 H-loop/switch region; other site 714359000912 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359000913 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359000914 dimer interface [polypeptide binding]; other site 714359000915 phosphorylation site [posttranslational modification] 714359000916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359000917 ATP binding site [chemical binding]; other site 714359000918 Mg2+ binding site [ion binding]; other site 714359000919 G-X-G motif; other site 714359000920 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359000921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359000922 active site 714359000923 phosphorylation site [posttranslational modification] 714359000924 intermolecular recognition site; other site 714359000925 dimerization interface [polypeptide binding]; other site 714359000926 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359000927 DNA binding site [nucleotide binding] 714359000928 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 714359000929 putative ligand binding site [chemical binding]; other site 714359000930 putative catalytic site [active] 714359000931 Methyltransferase domain; Region: Methyltransf_31; pfam13847 714359000932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359000933 S-adenosylmethionine binding site [chemical binding]; other site 714359000934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359000935 S-adenosylmethionine binding site [chemical binding]; other site 714359000936 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 714359000937 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359000938 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359000939 NAD(P) binding site [chemical binding]; other site 714359000940 active site 714359000941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359000942 S-adenosylmethionine binding site [chemical binding]; other site 714359000943 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714359000944 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 714359000945 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 714359000946 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359000947 active site 714359000948 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714359000949 EamA-like transporter family; Region: EamA; pfam00892 714359000950 EamA-like transporter family; Region: EamA; pfam00892 714359000951 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 714359000952 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 714359000953 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 714359000954 ATP-grasp domain; Region: ATP-grasp; pfam02222 714359000955 adenylosuccinate lyase; Provisional; Region: PRK07492 714359000956 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 714359000957 tetramer interface [polypeptide binding]; other site 714359000958 active site 714359000959 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 714359000960 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 714359000961 ATP binding site [chemical binding]; other site 714359000962 active site 714359000963 substrate binding site [chemical binding]; other site 714359000964 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 714359000965 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 714359000966 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 714359000967 putative active site [active] 714359000968 catalytic triad [active] 714359000969 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 714359000970 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 714359000971 dimerization interface [polypeptide binding]; other site 714359000972 ATP binding site [chemical binding]; other site 714359000973 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 714359000974 dimerization interface [polypeptide binding]; other site 714359000975 ATP binding site [chemical binding]; other site 714359000976 amidophosphoribosyltransferase; Provisional; Region: PRK06781 714359000977 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 714359000978 active site 714359000979 tetramer interface [polypeptide binding]; other site 714359000980 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714359000981 active site 714359000982 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 714359000983 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 714359000984 dimerization interface [polypeptide binding]; other site 714359000985 putative ATP binding site [chemical binding]; other site 714359000986 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 714359000987 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 714359000988 active site 714359000989 substrate binding site [chemical binding]; other site 714359000990 cosubstrate binding site; other site 714359000991 catalytic site [active] 714359000992 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 714359000993 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 714359000994 purine monophosphate binding site [chemical binding]; other site 714359000995 dimer interface [polypeptide binding]; other site 714359000996 putative catalytic residues [active] 714359000997 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 714359000998 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 714359000999 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 714359001000 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 714359001001 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 714359001002 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 714359001003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 714359001004 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 714359001005 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 714359001006 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 714359001007 PcrB family; Region: PcrB; pfam01884 714359001008 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 714359001009 substrate binding site [chemical binding]; other site 714359001010 putative active site [active] 714359001011 dimer interface [polypeptide binding]; other site 714359001012 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 714359001013 Part of AAA domain; Region: AAA_19; pfam13245 714359001014 Family description; Region: UvrD_C_2; pfam13538 714359001015 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 714359001016 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 714359001017 nucleotide binding pocket [chemical binding]; other site 714359001018 K-X-D-G motif; other site 714359001019 catalytic site [active] 714359001020 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 714359001021 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 714359001022 Dimer interface [polypeptide binding]; other site 714359001023 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 714359001024 putative dimer interface [polypeptide binding]; other site 714359001025 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 714359001026 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 714359001027 putative dimer interface [polypeptide binding]; other site 714359001028 hypothetical protein; Provisional; Region: PRK10621 714359001029 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359001030 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 714359001031 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 714359001032 Glutamate binding site [chemical binding]; other site 714359001033 homodimer interface [polypeptide binding]; other site 714359001034 NAD binding site [chemical binding]; other site 714359001035 catalytic residues [active] 714359001036 Isochorismatase family; Region: Isochorismatase; pfam00857 714359001037 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 714359001038 catalytic triad [active] 714359001039 conserved cis-peptide bond; other site 714359001040 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 714359001041 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 714359001042 Walker A/P-loop; other site 714359001043 ATP binding site [chemical binding]; other site 714359001044 Q-loop/lid; other site 714359001045 ABC transporter signature motif; other site 714359001046 Walker B; other site 714359001047 D-loop; other site 714359001048 H-loop/switch region; other site 714359001049 NIL domain; Region: NIL; pfam09383 714359001050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001051 dimer interface [polypeptide binding]; other site 714359001052 conserved gate region; other site 714359001053 ABC-ATPase subunit interface; other site 714359001054 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 714359001055 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 714359001056 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 714359001057 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 714359001058 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 714359001059 P loop; other site 714359001060 Nucleotide binding site [chemical binding]; other site 714359001061 DTAP/Switch II; other site 714359001062 Switch I; other site 714359001063 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 714359001064 putative dimer interface [polypeptide binding]; other site 714359001065 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359001066 MarR family; Region: MarR; pfam01047 714359001067 MarR family; Region: MarR_2; cl17246 714359001068 yiaA/B two helix domain; Region: YiaAB; pfam05360 714359001069 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 714359001070 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 714359001071 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 714359001072 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 714359001073 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 714359001074 GatB domain; Region: GatB_Yqey; pfam02637 714359001075 putative lipid kinase; Reviewed; Region: PRK13337 714359001076 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 714359001077 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359001078 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359001079 motif II; other site 714359001080 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 714359001081 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359001082 inhibitor-cofactor binding pocket; inhibition site 714359001083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359001084 catalytic residue [active] 714359001085 PAS domain; Region: PAS_9; pfam13426 714359001086 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359001087 putative active site [active] 714359001088 heme pocket [chemical binding]; other site 714359001089 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 714359001090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359001091 Walker A motif; other site 714359001092 ATP binding site [chemical binding]; other site 714359001093 Walker B motif; other site 714359001094 arginine finger; other site 714359001095 succinic semialdehyde dehydrogenase; Region: PLN02278 714359001096 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 714359001097 tetramerization interface [polypeptide binding]; other site 714359001098 NAD(P) binding site [chemical binding]; other site 714359001099 catalytic residues [active] 714359001100 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 714359001101 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 714359001102 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 714359001103 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 714359001104 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 714359001105 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 714359001106 putative active site [active] 714359001107 putative metal binding site [ion binding]; other site 714359001108 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714359001109 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714359001110 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359001111 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 714359001112 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 714359001113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359001114 S-adenosylmethionine binding site [chemical binding]; other site 714359001115 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 714359001116 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 714359001117 FMN binding site [chemical binding]; other site 714359001118 active site 714359001119 catalytic residues [active] 714359001120 substrate binding site [chemical binding]; other site 714359001121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 714359001122 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 714359001123 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 714359001124 Protein of unknown function DUF45; Region: DUF45; pfam01863 714359001125 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 714359001126 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 714359001127 active site 714359001128 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 714359001129 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 714359001130 amidohydrolase; Region: amidohydrolases; TIGR01891 714359001131 metal binding site [ion binding]; metal-binding site 714359001132 putative dimer interface [polypeptide binding]; other site 714359001133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359001134 S-adenosylmethionine binding site [chemical binding]; other site 714359001135 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 714359001136 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 714359001137 catalytic residue [active] 714359001138 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 714359001139 catalytic residues [active] 714359001140 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714359001141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714359001142 peroxiredoxin; Region: AhpC; TIGR03137 714359001143 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 714359001144 dimer interface [polypeptide binding]; other site 714359001145 decamer (pentamer of dimers) interface [polypeptide binding]; other site 714359001146 catalytic triad [active] 714359001147 peroxidatic and resolving cysteines [active] 714359001148 5-methylribose kinase; Reviewed; Region: PRK12396 714359001149 Phosphotransferase enzyme family; Region: APH; pfam01636 714359001150 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 714359001151 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 714359001152 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 714359001153 intersubunit interface [polypeptide binding]; other site 714359001154 active site 714359001155 Zn2+ binding site [ion binding]; other site 714359001156 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714359001157 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359001158 ABC-ATPase subunit interface; other site 714359001159 dimer interface [polypeptide binding]; other site 714359001160 putative PBP binding regions; other site 714359001161 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714359001162 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359001163 ABC-ATPase subunit interface; other site 714359001164 dimer interface [polypeptide binding]; other site 714359001165 putative PBP binding regions; other site 714359001166 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 714359001167 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 714359001168 putative ligand binding residues [chemical binding]; other site 714359001169 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 714359001170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714359001171 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 714359001172 Helix-turn-helix domain; Region: HTH_17; cl17695 714359001173 Sm and related proteins; Region: Sm_like; cl00259 714359001174 Sm1 motif; other site 714359001175 RNA binding site [nucleotide binding]; other site 714359001176 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 714359001177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359001178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359001179 dimer interface [polypeptide binding]; other site 714359001180 phosphorylation site [posttranslational modification] 714359001181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359001182 ATP binding site [chemical binding]; other site 714359001183 Mg2+ binding site [ion binding]; other site 714359001184 G-X-G motif; other site 714359001185 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 714359001186 hypothetical protein; Provisional; Region: PRK06851 714359001187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359001188 Walker A motif; other site 714359001189 ATP binding site [chemical binding]; other site 714359001190 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 714359001191 putative transposase OrfB; Reviewed; Region: PHA02517 714359001192 HTH-like domain; Region: HTH_21; pfam13276 714359001193 Integrase core domain; Region: rve; pfam00665 714359001194 Integrase core domain; Region: rve_2; pfam13333 714359001195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714359001196 Helix-turn-helix domain; Region: HTH_28; pfam13518 714359001197 Helix-turn-helix domain; Region: HTH_28; pfam13518 714359001198 benzoate transport; Region: 2A0115; TIGR00895 714359001199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359001200 putative substrate translocation pore; other site 714359001201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359001202 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 714359001203 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 714359001204 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 714359001205 [2Fe-2S] cluster binding site [ion binding]; other site 714359001206 Fatty acid desaturase; Region: FA_desaturase; pfam00487 714359001207 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 714359001208 putative di-iron ligands [ion binding]; other site 714359001209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001210 dimer interface [polypeptide binding]; other site 714359001211 conserved gate region; other site 714359001212 putative PBP binding loops; other site 714359001213 ABC-ATPase subunit interface; other site 714359001214 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 714359001215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359001216 substrate binding pocket [chemical binding]; other site 714359001217 membrane-bound complex binding site; other site 714359001218 hinge residues; other site 714359001219 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714359001220 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 714359001221 Walker A/P-loop; other site 714359001222 ATP binding site [chemical binding]; other site 714359001223 Q-loop/lid; other site 714359001224 ABC transporter signature motif; other site 714359001225 Walker B; other site 714359001226 D-loop; other site 714359001227 H-loop/switch region; other site 714359001228 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 714359001229 HAMP domain; Region: HAMP; pfam00672 714359001230 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359001231 dimer interface [polypeptide binding]; other site 714359001232 putative CheW interface [polypeptide binding]; other site 714359001233 Arginine repressor [Transcription]; Region: ArgR; COG1438 714359001234 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 714359001235 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 714359001236 arginine deiminase; Provisional; Region: PRK01388 714359001237 ornithine carbamoyltransferase; Validated; Region: PRK02102 714359001238 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 714359001239 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 714359001240 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 714359001241 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 714359001242 putative substrate binding site [chemical binding]; other site 714359001243 homodimer interface [polypeptide binding]; other site 714359001244 nucleotide binding site [chemical binding]; other site 714359001245 nucleotide binding site [chemical binding]; other site 714359001246 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 714359001247 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714359001248 ligand binding site [chemical binding]; other site 714359001249 flexible hinge region; other site 714359001250 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 714359001251 putative switch regulator; other site 714359001252 non-specific DNA interactions [nucleotide binding]; other site 714359001253 DNA binding site [nucleotide binding] 714359001254 sequence specific DNA binding site [nucleotide binding]; other site 714359001255 putative cAMP binding site [chemical binding]; other site 714359001256 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 714359001257 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 714359001258 FAD binding domain; Region: FAD_binding_4; pfam01565 714359001259 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 714359001260 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 714359001261 Ca binding site [ion binding]; other site 714359001262 active site 714359001263 catalytic site [active] 714359001264 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714359001265 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 714359001266 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714359001267 active site turn [active] 714359001268 phosphorylation site [posttranslational modification] 714359001269 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 714359001270 putative catalytic site [active] 714359001271 putative metal binding site [ion binding]; other site 714359001272 putative phosphate binding site [ion binding]; other site 714359001273 Predicted membrane protein [Function unknown]; Region: COG1511 714359001274 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 714359001275 Predicted membrane protein [Function unknown]; Region: COG1511 714359001276 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 714359001277 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 714359001278 dinuclear metal binding motif [ion binding]; other site 714359001279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359001280 DNA topoisomerase III; Provisional; Region: PRK07726 714359001281 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 714359001282 active site 714359001283 putative interdomain interaction site [polypeptide binding]; other site 714359001284 putative metal-binding site [ion binding]; other site 714359001285 putative nucleotide binding site [chemical binding]; other site 714359001286 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 714359001287 domain I; other site 714359001288 DNA binding groove [nucleotide binding] 714359001289 phosphate binding site [ion binding]; other site 714359001290 domain II; other site 714359001291 domain III; other site 714359001292 nucleotide binding site [chemical binding]; other site 714359001293 catalytic site [active] 714359001294 domain IV; other site 714359001295 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 714359001296 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 714359001297 substrate binding site [chemical binding]; other site 714359001298 multimerization interface [polypeptide binding]; other site 714359001299 ATP binding site [chemical binding]; other site 714359001300 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 714359001301 active site 714359001302 thiamine phosphate binding site [chemical binding]; other site 714359001303 pyrophosphate binding site [ion binding]; other site 714359001304 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 714359001305 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 714359001306 HAMP domain; Region: HAMP; pfam00672 714359001307 dimerization interface [polypeptide binding]; other site 714359001308 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359001309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359001310 dimer interface [polypeptide binding]; other site 714359001311 putative CheW interface [polypeptide binding]; other site 714359001312 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 714359001313 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 714359001314 acyl-activating enzyme (AAE) consensus motif; other site 714359001315 AMP binding site [chemical binding]; other site 714359001316 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359001317 thioester reductase domain; Region: Thioester-redct; TIGR01746 714359001318 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 714359001319 putative NAD(P) binding site [chemical binding]; other site 714359001320 active site 714359001321 putative substrate binding site [chemical binding]; other site 714359001322 Domain of unknown function DUF77; Region: DUF77; pfam01910 714359001323 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 714359001324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001325 dimer interface [polypeptide binding]; other site 714359001326 conserved gate region; other site 714359001327 putative PBP binding loops; other site 714359001328 ABC-ATPase subunit interface; other site 714359001329 NMT1/THI5 like; Region: NMT1; pfam09084 714359001330 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 714359001331 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 714359001332 ABC transporter; Region: ABC_tran; pfam00005 714359001333 Q-loop/lid; other site 714359001334 ABC transporter signature motif; other site 714359001335 Walker B; other site 714359001336 D-loop; other site 714359001337 H-loop/switch region; other site 714359001338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359001339 H-loop/switch region; other site 714359001340 Glyco_18 domain; Region: Glyco_18; smart00636 714359001341 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 714359001342 active site 714359001343 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 714359001344 Interdomain contacts; other site 714359001345 Cytokine receptor motif; other site 714359001346 Cellulose binding domain; Region: CBM_2; pfam00553 714359001347 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 714359001348 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359001349 catalytic residues [active] 714359001350 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359001351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359001352 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 714359001353 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359001354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359001355 putative substrate translocation pore; other site 714359001356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359001357 non-specific DNA binding site [nucleotide binding]; other site 714359001358 salt bridge; other site 714359001359 sequence-specific DNA binding site [nucleotide binding]; other site 714359001360 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 714359001361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359001362 putative substrate translocation pore; other site 714359001363 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 714359001364 Uncharacterized conserved protein [Function unknown]; Region: COG3379 714359001365 YesK-like protein; Region: YesK; pfam14150 714359001366 prolyl-tRNA synthetase; Provisional; Region: PRK08661 714359001367 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 714359001368 dimer interface [polypeptide binding]; other site 714359001369 motif 1; other site 714359001370 active site 714359001371 motif 2; other site 714359001372 motif 3; other site 714359001373 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 714359001374 anticodon binding site; other site 714359001375 zinc-binding site [ion binding]; other site 714359001376 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 714359001377 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 714359001378 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 714359001379 putative metal binding site [ion binding]; other site 714359001380 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 714359001381 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 714359001382 putative metal binding site [ion binding]; other site 714359001383 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 714359001384 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 714359001385 putative metal binding site [ion binding]; other site 714359001386 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 714359001387 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 714359001388 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 714359001389 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 714359001390 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 714359001391 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359001392 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 714359001393 Soluble P-type ATPase [General function prediction only]; Region: COG4087 714359001394 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 714359001395 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 714359001396 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 714359001397 Low molecular weight phosphatase family; Region: LMWPc; cd00115 714359001398 active site 714359001399 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 714359001400 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 714359001401 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 714359001402 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359001403 Soluble P-type ATPase [General function prediction only]; Region: COG4087 714359001404 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714359001405 EamA-like transporter family; Region: EamA; pfam00892 714359001406 EamA-like transporter family; Region: EamA; pfam00892 714359001407 YhhN-like protein; Region: YhhN; pfam07947 714359001408 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714359001409 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359001410 Catalytic site [active] 714359001411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359001412 binding surface 714359001413 Tetratricopeptide repeat; Region: TPR_16; pfam13432 714359001414 TPR motif; other site 714359001415 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714359001416 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 714359001417 Predicted membrane protein [Function unknown]; Region: COG2510 714359001418 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 714359001419 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 714359001420 calcium/proton exchanger (cax); Region: cax; TIGR00378 714359001421 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 714359001422 YfkD-like protein; Region: YfkD; pfam14167 714359001423 Radical SAM superfamily; Region: Radical_SAM; pfam04055 714359001424 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359001425 FeS/SAM binding site; other site 714359001426 YfkB-like domain; Region: YfkB; pfam08756 714359001427 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 714359001428 Fumarase C-terminus; Region: Fumerase_C; pfam05683 714359001429 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 714359001430 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 714359001431 NodB motif; other site 714359001432 active site 714359001433 catalytic site [active] 714359001434 Cd binding site [ion binding]; other site 714359001435 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 714359001436 endonuclease III; Region: ENDO3c; smart00478 714359001437 minor groove reading motif; other site 714359001438 helix-hairpin-helix signature motif; other site 714359001439 substrate binding pocket [chemical binding]; other site 714359001440 active site 714359001441 TRAM domain; Region: TRAM; pfam01938 714359001442 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 714359001443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359001444 S-adenosylmethionine binding site [chemical binding]; other site 714359001445 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 714359001446 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 714359001447 dimerization interface 3.5A [polypeptide binding]; other site 714359001448 active site 714359001449 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 714359001450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359001451 Walker A motif; other site 714359001452 ATP binding site [chemical binding]; other site 714359001453 Walker B motif; other site 714359001454 arginine finger; other site 714359001455 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 714359001456 hypothetical protein; Validated; Region: PRK06748 714359001457 S-methylmethionine transporter; Provisional; Region: PRK11387 714359001458 acetylornithine deacetylase; Validated; Region: PRK08596 714359001459 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 714359001460 metal binding site [ion binding]; metal-binding site 714359001461 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359001462 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359001463 non-specific DNA binding site [nucleotide binding]; other site 714359001464 salt bridge; other site 714359001465 sequence-specific DNA binding site [nucleotide binding]; other site 714359001466 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 714359001467 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 714359001468 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 714359001469 glutaminase A; Region: Gln_ase; TIGR03814 714359001470 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 714359001471 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 714359001472 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714359001473 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714359001474 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714359001475 active site turn [active] 714359001476 phosphorylation site [posttranslational modification] 714359001477 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359001478 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359001479 Sm and related proteins; Region: Sm_like; cl00259 714359001480 heptamer interface [polypeptide binding]; other site 714359001481 Sm1 motif; other site 714359001482 hexamer interface [polypeptide binding]; other site 714359001483 RNA binding site [nucleotide binding]; other site 714359001484 Sm2 motif; other site 714359001485 Sm and related proteins; Region: Sm_like; cl00259 714359001486 heptamer interface [polypeptide binding]; other site 714359001487 Sm1 motif; other site 714359001488 hexamer interface [polypeptide binding]; other site 714359001489 RNA binding site [nucleotide binding]; other site 714359001490 Sm2 motif; other site 714359001491 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 714359001492 active site 714359001493 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 714359001494 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 714359001495 active site 714359001496 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 714359001497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359001498 NAD(P) binding site [chemical binding]; other site 714359001499 active site 714359001500 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 714359001501 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 714359001502 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359001503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359001504 NAD(P) binding site [chemical binding]; other site 714359001505 active site 714359001506 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359001507 active site 714359001508 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 714359001509 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359001510 active site 714359001511 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 714359001512 Pyruvate formate lyase 1; Region: PFL1; cd01678 714359001513 coenzyme A binding site [chemical binding]; other site 714359001514 active site 714359001515 catalytic residues [active] 714359001516 glycine loop; other site 714359001517 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 714359001518 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359001519 FeS/SAM binding site; other site 714359001520 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 714359001521 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 714359001522 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 714359001523 YfhE-like protein; Region: YfhE; pfam14152 714359001524 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359001525 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 714359001526 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 714359001527 active site 714359001528 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 714359001529 TIGR01777 family protein; Region: yfcH 714359001530 putative NAD(P) binding site [chemical binding]; other site 714359001531 putative active site [active] 714359001532 recombination regulator RecX; Provisional; Region: recX; PRK14135 714359001533 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 714359001534 WVELL protein; Region: WVELL; pfam14043 714359001535 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 714359001536 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 714359001537 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 714359001538 minor groove reading motif; other site 714359001539 helix-hairpin-helix signature motif; other site 714359001540 substrate binding pocket [chemical binding]; other site 714359001541 active site 714359001542 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 714359001543 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 714359001544 DNA binding and oxoG recognition site [nucleotide binding] 714359001545 YgaB-like protein; Region: YgaB; pfam14182 714359001546 hypothetical protein; Provisional; Region: PRK13662 714359001547 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714359001548 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359001549 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 714359001550 Walker A/P-loop; other site 714359001551 ATP binding site [chemical binding]; other site 714359001552 Q-loop/lid; other site 714359001553 ABC transporter signature motif; other site 714359001554 Walker B; other site 714359001555 D-loop; other site 714359001556 H-loop/switch region; other site 714359001557 Predicted membrane protein [Function unknown]; Region: COG4129 714359001558 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 714359001559 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 714359001560 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 714359001561 active site 714359001562 dimer interface [polypeptide binding]; other site 714359001563 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 714359001564 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 714359001565 active site 714359001566 FMN binding site [chemical binding]; other site 714359001567 substrate binding site [chemical binding]; other site 714359001568 3Fe-4S cluster binding site [ion binding]; other site 714359001569 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 714359001570 domain_subunit interface; other site 714359001571 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 714359001572 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359001573 inhibitor-cofactor binding pocket; inhibition site 714359001574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359001575 catalytic residue [active] 714359001576 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 714359001577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359001578 Walker A/P-loop; other site 714359001579 ATP binding site [chemical binding]; other site 714359001580 Q-loop/lid; other site 714359001581 ABC transporter signature motif; other site 714359001582 Walker B; other site 714359001583 D-loop; other site 714359001584 H-loop/switch region; other site 714359001585 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 714359001586 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 714359001587 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 714359001588 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 714359001589 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 714359001590 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 714359001591 catalytic triad [active] 714359001592 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 714359001593 metal binding site 2 [ion binding]; metal-binding site 714359001594 putative DNA binding helix; other site 714359001595 metal binding site 1 [ion binding]; metal-binding site 714359001596 dimer interface [polypeptide binding]; other site 714359001597 structural Zn2+ binding site [ion binding]; other site 714359001598 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 714359001599 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 714359001600 hypothetical protein; Provisional; Region: PRK12378 714359001601 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 714359001602 nudix motif; other site 714359001603 Transglycosylase; Region: Transgly; pfam00912 714359001604 Thioredoxin; Region: Thioredoxin_4; pfam13462 714359001605 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 714359001606 epoxyqueuosine reductase; Region: TIGR00276 714359001607 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 714359001608 4Fe-4S binding domain; Region: Fer4; cl02805 714359001609 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 714359001610 Putative amidase domain; Region: Amidase_6; pfam12671 714359001611 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 714359001612 PAS fold; Region: PAS_4; pfam08448 714359001613 PAS domain; Region: PAS_9; pfam13426 714359001614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359001615 putative active site [active] 714359001616 heme pocket [chemical binding]; other site 714359001617 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714359001618 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359001619 metal binding site [ion binding]; metal-binding site 714359001620 active site 714359001621 I-site; other site 714359001622 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359001623 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 714359001624 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 714359001625 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 714359001626 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359001627 heme-binding site [chemical binding]; other site 714359001628 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 714359001629 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 714359001630 Leucine-rich repeats; other site 714359001631 Substrate binding site [chemical binding]; other site 714359001632 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359001633 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359001634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359001635 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359001636 Coenzyme A binding pocket [chemical binding]; other site 714359001637 BCCT family transporter; Region: BCCT; pfam02028 714359001638 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 714359001639 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 714359001640 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 714359001641 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 714359001642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 714359001643 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 714359001644 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 714359001645 Cache domain; Region: Cache_1; pfam02743 714359001646 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359001647 dimerization interface [polypeptide binding]; other site 714359001648 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359001649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359001650 dimer interface [polypeptide binding]; other site 714359001651 putative CheW interface [polypeptide binding]; other site 714359001652 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359001653 PAS domain; Region: PAS; smart00091 714359001654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359001655 ATP binding site [chemical binding]; other site 714359001656 Mg2+ binding site [ion binding]; other site 714359001657 G-X-G motif; other site 714359001658 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 714359001659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359001660 active site 714359001661 phosphorylation site [posttranslational modification] 714359001662 intermolecular recognition site; other site 714359001663 dimerization interface [polypeptide binding]; other site 714359001664 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 714359001665 Citrate transporter; Region: CitMHS; pfam03600 714359001666 hypothetical protein; Provisional; Region: PRK12784 714359001667 NosL; Region: NosL; cl01769 714359001668 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 714359001669 Ankyrin repeat; Region: Ank; pfam00023 714359001670 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 714359001671 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 714359001672 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 714359001673 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 714359001674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359001675 Walker A/P-loop; other site 714359001676 ATP binding site [chemical binding]; other site 714359001677 Q-loop/lid; other site 714359001678 ABC transporter signature motif; other site 714359001679 Walker B; other site 714359001680 D-loop; other site 714359001681 H-loop/switch region; other site 714359001682 TOBE domain; Region: TOBE_2; pfam08402 714359001683 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 714359001684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001685 dimer interface [polypeptide binding]; other site 714359001686 conserved gate region; other site 714359001687 putative PBP binding loops; other site 714359001688 ABC-ATPase subunit interface; other site 714359001689 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 714359001690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 714359001691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001692 dimer interface [polypeptide binding]; other site 714359001693 conserved gate region; other site 714359001694 putative PBP binding loops; other site 714359001695 ABC-ATPase subunit interface; other site 714359001696 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 714359001697 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 714359001698 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359001699 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 714359001700 active site 714359001701 metal binding site [ion binding]; metal-binding site 714359001702 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359001703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359001704 active site 714359001705 phosphorylation site [posttranslational modification] 714359001706 intermolecular recognition site; other site 714359001707 dimerization interface [polypeptide binding]; other site 714359001708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359001709 DNA binding site [nucleotide binding] 714359001710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359001711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359001712 dimer interface [polypeptide binding]; other site 714359001713 phosphorylation site [posttranslational modification] 714359001714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359001715 ATP binding site [chemical binding]; other site 714359001716 Mg2+ binding site [ion binding]; other site 714359001717 G-X-G motif; other site 714359001718 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 714359001719 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 714359001720 putative active site [active] 714359001721 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 714359001722 Cache domain; Region: Cache_1; pfam02743 714359001723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359001724 dimerization interface [polypeptide binding]; other site 714359001725 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359001726 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359001727 dimer interface [polypeptide binding]; other site 714359001728 putative CheW interface [polypeptide binding]; other site 714359001729 sensory histidine kinase DcuS; Provisional; Region: PRK11086 714359001730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359001731 ATP binding site [chemical binding]; other site 714359001732 Mg2+ binding site [ion binding]; other site 714359001733 G-X-G motif; other site 714359001734 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 714359001735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359001736 active site 714359001737 phosphorylation site [posttranslational modification] 714359001738 intermolecular recognition site; other site 714359001739 dimerization interface [polypeptide binding]; other site 714359001740 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 714359001741 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 714359001742 Malic enzyme, N-terminal domain; Region: malic; pfam00390 714359001743 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 714359001744 putative NAD(P) binding site [chemical binding]; other site 714359001745 EamA-like transporter family; Region: EamA; pfam00892 714359001746 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359001747 EamA-like transporter family; Region: EamA; pfam00892 714359001748 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359001749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359001750 DNA-binding site [nucleotide binding]; DNA binding site 714359001751 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359001752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359001753 homodimer interface [polypeptide binding]; other site 714359001754 catalytic residue [active] 714359001755 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 714359001756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359001757 Coenzyme A binding pocket [chemical binding]; other site 714359001758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359001759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359001760 dimerization interface [polypeptide binding]; other site 714359001761 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359001762 dimer interface [polypeptide binding]; other site 714359001763 phosphorylation site [posttranslational modification] 714359001764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359001765 ATP binding site [chemical binding]; other site 714359001766 Mg2+ binding site [ion binding]; other site 714359001767 G-X-G motif; other site 714359001768 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359001769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359001770 active site 714359001771 phosphorylation site [posttranslational modification] 714359001772 intermolecular recognition site; other site 714359001773 dimerization interface [polypeptide binding]; other site 714359001774 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359001775 DNA binding site [nucleotide binding] 714359001776 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 714359001777 Arrestin_N terminal like; Region: LDB19; pfam13002 714359001778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359001779 Coenzyme A binding pocket [chemical binding]; other site 714359001780 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 714359001781 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 714359001782 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 714359001783 [4Fe-4S] binding site [ion binding]; other site 714359001784 molybdopterin cofactor binding site; other site 714359001785 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 714359001786 molybdopterin cofactor binding site; other site 714359001787 Uncharacterized conserved protein [Function unknown]; Region: COG2427 714359001788 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 714359001789 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 714359001790 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 714359001791 putative active site [active] 714359001792 catalytic site [active] 714359001793 putative metal binding site [ion binding]; other site 714359001794 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 714359001795 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 714359001796 hexamer interface [polypeptide binding]; other site 714359001797 ligand binding site [chemical binding]; other site 714359001798 putative active site [active] 714359001799 NAD(P) binding site [chemical binding]; other site 714359001800 amino acid transporter; Region: 2A0306; TIGR00909 714359001801 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 714359001802 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359001803 dimerization interface [polypeptide binding]; other site 714359001804 putative DNA binding site [nucleotide binding]; other site 714359001805 putative Zn2+ binding site [ion binding]; other site 714359001806 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359001807 metal-binding site [ion binding] 714359001808 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 714359001809 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359001810 metal-binding site [ion binding] 714359001811 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359001812 Soluble P-type ATPase [General function prediction only]; Region: COG4087 714359001813 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 714359001814 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 714359001815 active site 714359001816 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359001817 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359001818 non-specific DNA binding site [nucleotide binding]; other site 714359001819 salt bridge; other site 714359001820 sequence-specific DNA binding site [nucleotide binding]; other site 714359001821 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359001822 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359001823 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359001824 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 714359001825 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 714359001826 active site 714359001827 Zn binding site [ion binding]; other site 714359001828 Uncharacterized conserved protein [Function unknown]; Region: COG0398 714359001829 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 714359001830 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 714359001831 VanW like protein; Region: VanW; pfam04294 714359001832 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 714359001833 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714359001834 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714359001835 Nucleoside recognition; Region: Gate; pfam07670 714359001836 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359001837 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359001838 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 714359001839 putative metal binding site [ion binding]; other site 714359001840 FOG: CBS domain [General function prediction only]; Region: COG0517 714359001841 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714359001842 Transporter associated domain; Region: CorC_HlyC; smart01091 714359001843 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 714359001844 Aspartase; Region: Aspartase; cd01357 714359001845 active sites [active] 714359001846 tetramer interface [polypeptide binding]; other site 714359001847 L-lactate permease; Region: Lactate_perm; cl00701 714359001848 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 714359001849 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359001850 dimerization interface [polypeptide binding]; other site 714359001851 putative Zn2+ binding site [ion binding]; other site 714359001852 putative DNA binding site [nucleotide binding]; other site 714359001853 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 714359001854 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 714359001855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359001856 putative substrate translocation pore; other site 714359001857 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 714359001858 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 714359001859 siderophore binding site; other site 714359001860 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714359001861 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359001862 ABC-ATPase subunit interface; other site 714359001863 dimer interface [polypeptide binding]; other site 714359001864 putative PBP binding regions; other site 714359001865 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 714359001866 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359001867 ABC-ATPase subunit interface; other site 714359001868 dimer interface [polypeptide binding]; other site 714359001869 putative PBP binding regions; other site 714359001870 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714359001871 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714359001872 Walker A/P-loop; other site 714359001873 ATP binding site [chemical binding]; other site 714359001874 Q-loop/lid; other site 714359001875 ABC transporter signature motif; other site 714359001876 Walker B; other site 714359001877 D-loop; other site 714359001878 H-loop/switch region; other site 714359001879 Methyltransferase domain; Region: Methyltransf_31; pfam13847 714359001880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359001881 S-adenosylmethionine binding site [chemical binding]; other site 714359001882 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 714359001883 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 714359001884 substrate-cofactor binding pocket; other site 714359001885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359001886 catalytic residue [active] 714359001887 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359001888 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 714359001889 NAD binding site [chemical binding]; other site 714359001890 homodimer interface [polypeptide binding]; other site 714359001891 active site 714359001892 putative substrate binding site [chemical binding]; other site 714359001893 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 714359001894 nudix motif; other site 714359001895 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 714359001896 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 714359001897 metal ion-dependent adhesion site (MIDAS); other site 714359001898 MoxR-like ATPases [General function prediction only]; Region: COG0714 714359001899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359001900 Walker A motif; other site 714359001901 ATP binding site [chemical binding]; other site 714359001902 Walker B motif; other site 714359001903 arginine finger; other site 714359001904 cardiolipin synthetase; Reviewed; Region: PRK12452 714359001905 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 714359001906 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 714359001907 putative active site [active] 714359001908 catalytic site [active] 714359001909 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 714359001910 putative active site [active] 714359001911 catalytic site [active] 714359001912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359001913 PAS domain; Region: PAS_9; pfam13426 714359001914 putative active site [active] 714359001915 heme pocket [chemical binding]; other site 714359001916 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359001917 metal binding site [ion binding]; metal-binding site 714359001918 active site 714359001919 I-site; other site 714359001920 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359001921 putrescine transporter; Provisional; Region: potE; PRK10655 714359001922 Spore germination protein; Region: Spore_permease; cl17796 714359001923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359001924 DNA-binding site [nucleotide binding]; DNA binding site 714359001925 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 714359001926 UTRA domain; Region: UTRA; pfam07702 714359001927 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 714359001928 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714359001929 active site turn [active] 714359001930 phosphorylation site [posttranslational modification] 714359001931 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714359001932 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 714359001933 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 714359001934 Ca binding site [ion binding]; other site 714359001935 active site 714359001936 catalytic site [active] 714359001937 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 714359001938 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 714359001939 Spore germination protein; Region: Spore_permease; cl17796 714359001940 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359001941 CAAX protease self-immunity; Region: Abi; pfam02517 714359001942 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 714359001943 active site 714359001944 ATP binding site [chemical binding]; other site 714359001945 substrate binding site [chemical binding]; other site 714359001946 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 714359001947 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 714359001948 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714359001949 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 714359001950 Walker A/P-loop; other site 714359001951 ATP binding site [chemical binding]; other site 714359001952 Q-loop/lid; other site 714359001953 ABC transporter signature motif; other site 714359001954 Walker B; other site 714359001955 D-loop; other site 714359001956 H-loop/switch region; other site 714359001957 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 714359001958 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359001959 substrate binding pocket [chemical binding]; other site 714359001960 membrane-bound complex binding site; other site 714359001961 hinge residues; other site 714359001962 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714359001963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001964 dimer interface [polypeptide binding]; other site 714359001965 conserved gate region; other site 714359001966 putative PBP binding loops; other site 714359001967 ABC-ATPase subunit interface; other site 714359001968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001969 dimer interface [polypeptide binding]; other site 714359001970 conserved gate region; other site 714359001971 putative PBP binding loops; other site 714359001972 ABC-ATPase subunit interface; other site 714359001973 S-methylmethionine transporter; Provisional; Region: PRK11387 714359001974 OsmC-like protein; Region: OsmC; pfam02566 714359001975 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 714359001976 nucleotide binding site/active site [active] 714359001977 HIT family signature motif; other site 714359001978 catalytic residue [active] 714359001979 Predicted transcriptional regulator [Transcription]; Region: COG2378 714359001980 HTH domain; Region: HTH_11; pfam08279 714359001981 WYL domain; Region: WYL; pfam13280 714359001982 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 714359001983 RibD C-terminal domain; Region: RibD_C; cl17279 714359001984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359001985 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359001986 dimerization interface [polypeptide binding]; other site 714359001987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359001988 dimer interface [polypeptide binding]; other site 714359001989 phosphorylation site [posttranslational modification] 714359001990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359001991 ATP binding site [chemical binding]; other site 714359001992 Mg2+ binding site [ion binding]; other site 714359001993 G-X-G motif; other site 714359001994 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359001995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359001996 active site 714359001997 phosphorylation site [posttranslational modification] 714359001998 intermolecular recognition site; other site 714359001999 dimerization interface [polypeptide binding]; other site 714359002000 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359002001 DNA binding site [nucleotide binding] 714359002002 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 714359002003 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 714359002004 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 714359002005 Sulfate transporter family; Region: Sulfate_transp; pfam00916 714359002006 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 714359002007 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714359002008 Ligand Binding Site [chemical binding]; other site 714359002009 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 714359002010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002011 putative substrate translocation pore; other site 714359002012 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359002013 MarR family; Region: MarR; pfam01047 714359002014 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359002015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002016 putative substrate translocation pore; other site 714359002017 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359002018 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359002019 DNA binding site [nucleotide binding] 714359002020 domain linker motif; other site 714359002021 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 714359002022 dimerization interface [polypeptide binding]; other site 714359002023 ligand binding site [chemical binding]; other site 714359002024 sodium binding site [ion binding]; other site 714359002025 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714359002026 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 714359002027 substrate binding site [chemical binding]; other site 714359002028 dimer interface [polypeptide binding]; other site 714359002029 ATP binding site [chemical binding]; other site 714359002030 D-ribose pyranase; Provisional; Region: PRK11797 714359002031 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 714359002032 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 714359002033 Walker A/P-loop; other site 714359002034 ATP binding site [chemical binding]; other site 714359002035 Q-loop/lid; other site 714359002036 ABC transporter signature motif; other site 714359002037 Walker B; other site 714359002038 D-loop; other site 714359002039 H-loop/switch region; other site 714359002040 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 714359002041 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714359002042 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714359002043 TM-ABC transporter signature motif; other site 714359002044 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 714359002045 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 714359002046 ligand binding site [chemical binding]; other site 714359002047 dimerization interface [polypeptide binding]; other site 714359002048 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 714359002049 active site 714359002050 intersubunit interactions; other site 714359002051 catalytic residue [active] 714359002052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 714359002053 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 714359002054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359002056 putative substrate translocation pore; other site 714359002057 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714359002058 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 714359002059 putative NAD(P) binding site [chemical binding]; other site 714359002060 catalytic Zn binding site [ion binding]; other site 714359002061 Ion channel; Region: Ion_trans_2; pfam07885 714359002062 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 714359002063 Zn binding site [ion binding]; other site 714359002064 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 714359002065 putative catalytic site [active] 714359002066 metal binding site A [ion binding]; metal-binding site 714359002067 phosphate binding site [ion binding]; other site 714359002068 metal binding site C [ion binding]; metal-binding site 714359002069 metal binding site B [ion binding]; metal-binding site 714359002070 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 714359002071 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 714359002072 dimer interface [polypeptide binding]; other site 714359002073 active site 714359002074 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714359002075 substrate binding site [chemical binding]; other site 714359002076 catalytic residue [active] 714359002077 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 714359002078 FAD binding domain; Region: FAD_binding_4; pfam01565 714359002079 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 714359002080 VanZ like family; Region: VanZ; pfam04892 714359002081 RDD family; Region: RDD; pfam06271 714359002082 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 714359002083 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 714359002084 homodimer interface [polypeptide binding]; other site 714359002085 putative GKAP docking site [polypeptide binding]; other site 714359002086 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359002087 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359002088 dimer interface [polypeptide binding]; other site 714359002089 putative CheW interface [polypeptide binding]; other site 714359002090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 714359002091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 714359002092 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359002093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359002094 non-specific DNA binding site [nucleotide binding]; other site 714359002095 salt bridge; other site 714359002096 sequence-specific DNA binding site [nucleotide binding]; other site 714359002097 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 714359002098 active site 714359002099 catalytic site [active] 714359002100 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 714359002101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002102 POT family; Region: PTR2; cl17359 714359002103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002104 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 714359002105 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cd00890 714359002106 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 714359002107 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 714359002108 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 714359002109 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 714359002110 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359002111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359002112 non-specific DNA binding site [nucleotide binding]; other site 714359002113 salt bridge; other site 714359002114 sequence-specific DNA binding site [nucleotide binding]; other site 714359002115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359002116 Coenzyme A binding pocket [chemical binding]; other site 714359002117 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 714359002118 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 714359002119 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 714359002120 TrkA-N domain; Region: TrkA_N; pfam02254 714359002121 TrkA-C domain; Region: TrkA_C; pfam02080 714359002122 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 714359002123 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 714359002124 Subunit I/III interface [polypeptide binding]; other site 714359002125 Subunit III/IV interface [polypeptide binding]; other site 714359002126 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 714359002127 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 714359002128 D-pathway; other site 714359002129 Putative ubiquinol binding site [chemical binding]; other site 714359002130 Low-spin heme (heme b) binding site [chemical binding]; other site 714359002131 Putative water exit pathway; other site 714359002132 Binuclear center (heme o3/CuB) [ion binding]; other site 714359002133 K-pathway; other site 714359002134 Putative proton exit pathway; other site 714359002135 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 714359002136 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 714359002137 S-methylmethionine transporter; Provisional; Region: PRK11387 714359002138 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 714359002139 putative active site [active] 714359002140 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 714359002141 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 714359002142 metal binding site [ion binding]; metal-binding site 714359002143 dimer interface [polypeptide binding]; other site 714359002144 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 714359002145 Na binding site [ion binding]; other site 714359002146 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359002147 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 714359002148 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 714359002149 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 714359002150 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 714359002151 Nucleoside recognition; Region: Gate; pfam07670 714359002152 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 714359002153 Nucleoside recognition; Region: Gate; pfam07670 714359002154 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 714359002155 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 714359002156 G1 box; other site 714359002157 GTP/Mg2+ binding site [chemical binding]; other site 714359002158 Switch I region; other site 714359002159 G2 box; other site 714359002160 G3 box; other site 714359002161 Switch II region; other site 714359002162 G4 box; other site 714359002163 G5 box; other site 714359002164 FeoA domain; Region: FeoA; pfam04023 714359002165 phosphate binding protein; Region: ptsS_2; TIGR02136 714359002166 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 714359002167 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 714359002168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002169 dimer interface [polypeptide binding]; other site 714359002170 conserved gate region; other site 714359002171 putative PBP binding loops; other site 714359002172 ABC-ATPase subunit interface; other site 714359002173 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 714359002174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002175 dimer interface [polypeptide binding]; other site 714359002176 conserved gate region; other site 714359002177 putative PBP binding loops; other site 714359002178 ABC-ATPase subunit interface; other site 714359002179 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 714359002180 Protein export membrane protein; Region: SecD_SecF; cl14618 714359002181 FOG: CBS domain [General function prediction only]; Region: COG0517 714359002182 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 714359002183 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 714359002184 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 714359002185 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359002186 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359002187 Bacterial SH3 domain; Region: SH3_3; cl17532 714359002188 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 714359002189 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359002190 Putative transcription activator [Transcription]; Region: TenA; COG0819 714359002191 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 714359002192 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 714359002193 Walker A/P-loop; other site 714359002194 ATP binding site [chemical binding]; other site 714359002195 Q-loop/lid; other site 714359002196 ABC transporter signature motif; other site 714359002197 Walker B; other site 714359002198 D-loop; other site 714359002199 H-loop/switch region; other site 714359002200 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 714359002201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002202 dimer interface [polypeptide binding]; other site 714359002203 conserved gate region; other site 714359002204 putative PBP binding loops; other site 714359002205 ABC-ATPase subunit interface; other site 714359002206 NMT1/THI5 like; Region: NMT1; pfam09084 714359002207 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 714359002208 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 714359002209 thiamine phosphate binding site [chemical binding]; other site 714359002210 active site 714359002211 pyrophosphate binding site [ion binding]; other site 714359002212 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 714359002213 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 714359002214 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 714359002215 thiS-thiF/thiG interaction site; other site 714359002216 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 714359002217 ThiS interaction site; other site 714359002218 putative active site [active] 714359002219 tetramer interface [polypeptide binding]; other site 714359002220 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 714359002221 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 714359002222 ATP binding site [chemical binding]; other site 714359002223 substrate interface [chemical binding]; other site 714359002224 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 714359002225 dimer interface [polypeptide binding]; other site 714359002226 substrate binding site [chemical binding]; other site 714359002227 ATP binding site [chemical binding]; other site 714359002228 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 714359002229 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 714359002230 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359002231 Soluble P-type ATPase [General function prediction only]; Region: COG4087 714359002232 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 714359002233 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 714359002234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002235 putative substrate translocation pore; other site 714359002236 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359002237 MarR family; Region: MarR; pfam01047 714359002238 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 714359002239 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 714359002240 active site 714359002241 nucleophile elbow; other site 714359002242 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 714359002243 short chain dehydrogenase; Provisional; Region: PRK06701 714359002244 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 714359002245 NAD binding site [chemical binding]; other site 714359002246 metal binding site [ion binding]; metal-binding site 714359002247 active site 714359002248 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 714359002249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 714359002250 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714359002251 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 714359002252 putative substrate binding site [chemical binding]; other site 714359002253 putative ATP binding site [chemical binding]; other site 714359002254 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 714359002255 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 714359002256 substrate binding [chemical binding]; other site 714359002257 active site 714359002258 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 714359002259 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 714359002260 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714359002261 active site turn [active] 714359002262 phosphorylation site [posttranslational modification] 714359002263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714359002264 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359002265 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359002266 DNA binding site [nucleotide binding] 714359002267 domain linker motif; other site 714359002268 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 714359002269 dimerization interface [polypeptide binding]; other site 714359002270 ligand binding site [chemical binding]; other site 714359002271 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 714359002272 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359002273 catalytic residues [active] 714359002274 putative disulfide oxidoreductase; Provisional; Region: PRK03113 714359002275 YhdB-like protein; Region: YhdB; pfam14148 714359002276 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 714359002277 Spore germination protein; Region: Spore_permease; pfam03845 714359002278 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 714359002279 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 714359002280 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359002281 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 714359002282 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 714359002283 putative FMN binding site [chemical binding]; other site 714359002284 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 714359002285 SpoVR like protein; Region: SpoVR; pfam04293 714359002286 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 714359002287 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 714359002288 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 714359002289 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 714359002290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714359002291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714359002292 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714359002293 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 714359002294 active site residue [active] 714359002295 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 714359002296 putative homodimer interface [polypeptide binding]; other site 714359002297 putative homotetramer interface [polypeptide binding]; other site 714359002298 putative metal binding site [ion binding]; other site 714359002299 putative homodimer-homodimer interface [polypeptide binding]; other site 714359002300 putative allosteric switch controlling residues; other site 714359002301 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 714359002302 CPxP motif; other site 714359002303 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714359002304 active site residue [active] 714359002305 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 714359002306 active site residue [active] 714359002307 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359002308 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 714359002309 CPxP motif; other site 714359002310 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714359002311 active site residue [active] 714359002312 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714359002313 active site residue [active] 714359002314 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 714359002315 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359002316 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 714359002317 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 714359002318 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 714359002319 NADP binding site [chemical binding]; other site 714359002320 dimer interface [polypeptide binding]; other site 714359002321 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 714359002322 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 714359002323 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 714359002324 PhoU domain; Region: PhoU; pfam01895 714359002325 PhoU domain; Region: PhoU; pfam01895 714359002326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359002328 putative substrate translocation pore; other site 714359002329 Uncharacterized conserved protein [Function unknown]; Region: COG3589 714359002330 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 714359002331 HTH domain; Region: HTH_11; pfam08279 714359002332 putative frv operon regulatory protein; Provisional; Region: PRK09863 714359002333 Mga helix-turn-helix domain; Region: Mga; pfam05043 714359002334 PRD domain; Region: PRD; pfam00874 714359002335 PRD domain; Region: PRD; pfam00874 714359002336 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 714359002337 active site 714359002338 P-loop; other site 714359002339 phosphorylation site [posttranslational modification] 714359002340 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714359002341 active site 714359002342 phosphorylation site [posttranslational modification] 714359002343 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 714359002344 active site 714359002345 methionine cluster; other site 714359002346 phosphorylation site [posttranslational modification] 714359002347 metal binding site [ion binding]; metal-binding site 714359002348 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 714359002349 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 714359002350 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 714359002351 Uncharacterized conserved protein [Function unknown]; Region: COG3589 714359002352 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 714359002353 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359002354 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359002355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 714359002356 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 714359002357 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 714359002358 FtsX-like permease family; Region: FtsX; pfam02687 714359002359 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359002360 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714359002361 Walker A/P-loop; other site 714359002362 ATP binding site [chemical binding]; other site 714359002363 Q-loop/lid; other site 714359002364 ABC transporter signature motif; other site 714359002365 Walker B; other site 714359002366 D-loop; other site 714359002367 H-loop/switch region; other site 714359002368 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 714359002369 HlyD family secretion protein; Region: HlyD_3; pfam13437 714359002370 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 714359002371 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 714359002372 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 714359002373 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 714359002374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002375 dimer interface [polypeptide binding]; other site 714359002376 conserved gate region; other site 714359002377 ABC-ATPase subunit interface; other site 714359002378 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 714359002379 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 714359002380 dimanganese center [ion binding]; other site 714359002381 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359002382 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 714359002383 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 714359002384 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 714359002385 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 714359002386 putative DNA binding site [nucleotide binding]; other site 714359002387 putative homodimer interface [polypeptide binding]; other site 714359002388 Uncharacterized conserved protein [Function unknown]; Region: COG3339 714359002389 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714359002390 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 714359002391 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 714359002392 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 714359002393 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 714359002394 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359002395 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 714359002396 active site 714359002397 metal binding site [ion binding]; metal-binding site 714359002398 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 714359002399 Interdomain contacts; other site 714359002400 Cytokine receptor motif; other site 714359002401 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 714359002402 amino acid transporter; Region: 2A0306; TIGR00909 714359002403 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 714359002404 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 714359002405 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 714359002406 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 714359002407 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 714359002408 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 714359002409 putative active site [active] 714359002410 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 714359002411 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 714359002412 putative active site [active] 714359002413 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714359002414 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 714359002415 active site turn [active] 714359002416 phosphorylation site [posttranslational modification] 714359002417 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714359002418 Uncharacterized conserved protein [Function unknown]; Region: COG3589 714359002419 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 714359002420 DoxX; Region: DoxX; pfam07681 714359002421 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 714359002422 hypothetical protein; Provisional; Region: PRK06770 714359002423 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714359002424 EamA-like transporter family; Region: EamA; pfam00892 714359002425 EamA-like transporter family; Region: EamA; pfam00892 714359002426 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 714359002427 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 714359002428 AsnC family; Region: AsnC_trans_reg; pfam01037 714359002429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359002430 Coenzyme A binding pocket [chemical binding]; other site 714359002431 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 714359002432 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 714359002433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359002434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359002435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002436 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359002437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002438 Predicted transcriptional regulators [Transcription]; Region: COG1733 714359002439 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359002440 dimerization interface [polypeptide binding]; other site 714359002441 putative DNA binding site [nucleotide binding]; other site 714359002442 putative Zn2+ binding site [ion binding]; other site 714359002443 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 714359002444 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 714359002445 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 714359002446 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 714359002447 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 714359002448 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 714359002449 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359002450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002451 putative substrate translocation pore; other site 714359002452 intracellular protease, PfpI family; Region: PfpI; TIGR01382 714359002453 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 714359002454 proposed catalytic triad [active] 714359002455 conserved cys residue [active] 714359002456 hydroperoxidase II; Provisional; Region: katE; PRK11249 714359002457 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 714359002458 tetramer interface [polypeptide binding]; other site 714359002459 heme binding pocket [chemical binding]; other site 714359002460 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 714359002461 domain interactions; other site 714359002462 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 714359002463 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 714359002464 Spore germination protein; Region: Spore_permease; cl17796 714359002465 glutamate racemase; Provisional; Region: PRK00865 714359002466 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 714359002467 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 714359002468 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 714359002469 tetrameric interface [polypeptide binding]; other site 714359002470 activator binding site; other site 714359002471 NADP binding site [chemical binding]; other site 714359002472 substrate binding site [chemical binding]; other site 714359002473 catalytic residues [active] 714359002474 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 714359002475 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359002476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359002477 Walker A/P-loop; other site 714359002478 ATP binding site [chemical binding]; other site 714359002479 Q-loop/lid; other site 714359002480 ABC transporter signature motif; other site 714359002481 Walker B; other site 714359002482 D-loop; other site 714359002483 H-loop/switch region; other site 714359002484 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359002485 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 714359002486 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 714359002487 Walker A/P-loop; other site 714359002488 ATP binding site [chemical binding]; other site 714359002489 Q-loop/lid; other site 714359002490 ABC transporter signature motif; other site 714359002491 Walker B; other site 714359002492 D-loop; other site 714359002493 H-loop/switch region; other site 714359002494 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 714359002495 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359002496 substrate binding pocket [chemical binding]; other site 714359002497 membrane-bound complex binding site; other site 714359002498 hinge residues; other site 714359002499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002500 dimer interface [polypeptide binding]; other site 714359002501 conserved gate region; other site 714359002502 putative PBP binding loops; other site 714359002503 ABC-ATPase subunit interface; other site 714359002504 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714359002505 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 714359002506 Walker A/P-loop; other site 714359002507 ATP binding site [chemical binding]; other site 714359002508 Q-loop/lid; other site 714359002509 ABC transporter signature motif; other site 714359002510 Walker B; other site 714359002511 D-loop; other site 714359002512 H-loop/switch region; other site 714359002513 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359002514 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 714359002515 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 714359002516 Protein of unknown function (DUF445); Region: DUF445; pfam04286 714359002517 hypothetical protein; Provisional; Region: PRK13676 714359002518 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 714359002519 protein binding site [polypeptide binding]; other site 714359002520 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 714359002521 Histidine kinase; Region: HisKA_3; pfam07730 714359002522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359002523 ATP binding site [chemical binding]; other site 714359002524 Mg2+ binding site [ion binding]; other site 714359002525 G-X-G motif; other site 714359002526 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359002527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359002528 active site 714359002529 phosphorylation site [posttranslational modification] 714359002530 intermolecular recognition site; other site 714359002531 dimerization interface [polypeptide binding]; other site 714359002532 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359002533 DNA binding residues [nucleotide binding] 714359002534 dimerization interface [polypeptide binding]; other site 714359002535 acetolactate synthase; Reviewed; Region: PRK08617 714359002536 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 714359002537 PYR/PP interface [polypeptide binding]; other site 714359002538 dimer interface [polypeptide binding]; other site 714359002539 TPP binding site [chemical binding]; other site 714359002540 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 714359002541 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 714359002542 TPP-binding site [chemical binding]; other site 714359002543 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 714359002544 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 714359002545 active site 714359002546 DNA binding site [nucleotide binding] 714359002547 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 714359002548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 714359002549 active site 714359002550 motif I; other site 714359002551 motif II; other site 714359002552 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 714359002553 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 714359002554 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 714359002555 Cna protein B-type domain; Region: Cna_B; pfam05738 714359002556 Cna protein B-type domain; Region: Cna_B; pfam05738 714359002557 Cna protein B-type domain; Region: Cna_B; pfam05738 714359002558 Cna protein B-type domain; Region: Cna_B; pfam05738 714359002559 Cna protein B-type domain; Region: Cna_B; pfam05738 714359002560 Cna protein B-type domain; Region: Cna_B; pfam05738 714359002561 Cna protein B-type domain; Region: Cna_B; pfam05738 714359002562 Cna protein B-type domain; Region: Cna_B; pfam05738 714359002563 Cna protein B-type domain; Region: Cna_B; pfam05738 714359002564 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 714359002565 amidase catalytic site [active] 714359002566 Zn binding residues [ion binding]; other site 714359002567 substrate binding site [chemical binding]; other site 714359002568 S-layer homology domain; Region: SLH; pfam00395 714359002569 S-layer homology domain; Region: SLH; pfam00395 714359002570 S-layer homology domain; Region: SLH; pfam00395 714359002571 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 714359002572 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359002573 FeS/SAM binding site; other site 714359002574 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 714359002575 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 714359002576 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 714359002577 acyl-activating enzyme (AAE) consensus motif; other site 714359002578 acyl-activating enzyme (AAE) consensus motif; other site 714359002579 putative AMP binding site [chemical binding]; other site 714359002580 putative active site [active] 714359002581 putative CoA binding site [chemical binding]; other site 714359002582 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 714359002583 Sulfate transporter family; Region: Sulfate_transp; pfam00916 714359002584 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 714359002585 stage V sporulation protein B; Region: spore_V_B; TIGR02900 714359002586 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 714359002587 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 714359002588 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 714359002589 S-layer homology domain; Region: SLH; pfam00395 714359002590 S-layer homology domain; Region: SLH; pfam00395 714359002591 S-layer homology domain; Region: SLH; pfam00395 714359002592 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 714359002593 O-Antigen ligase; Region: Wzy_C; cl04850 714359002594 enoyl-CoA hydratase; Provisional; Region: PRK07659 714359002595 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714359002596 substrate binding site [chemical binding]; other site 714359002597 oxyanion hole (OAH) forming residues; other site 714359002598 trimer interface [polypeptide binding]; other site 714359002599 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 714359002600 metal binding site [ion binding]; metal-binding site 714359002601 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 714359002602 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 714359002603 putative oligomer interface [polypeptide binding]; other site 714359002604 putative active site [active] 714359002605 metal binding site [ion binding]; metal-binding site 714359002606 S-layer homology domain; Region: SLH; pfam00395 714359002607 S-layer homology domain; Region: SLH; pfam00395 714359002608 S-layer homology domain; Region: SLH; pfam00395 714359002609 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 714359002610 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714359002611 active site 714359002612 metal binding site [ion binding]; metal-binding site 714359002613 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 714359002614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359002615 S-adenosylmethionine binding site [chemical binding]; other site 714359002616 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 714359002617 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 714359002618 ornithine cyclodeaminase; Validated; Region: PRK08618 714359002619 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 714359002620 NAD(P) binding site [chemical binding]; other site 714359002621 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 714359002622 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 714359002623 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 714359002624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002625 dimer interface [polypeptide binding]; other site 714359002626 conserved gate region; other site 714359002627 putative PBP binding loops; other site 714359002628 ABC-ATPase subunit interface; other site 714359002629 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 714359002630 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 714359002631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002632 dimer interface [polypeptide binding]; other site 714359002633 conserved gate region; other site 714359002634 putative PBP binding loops; other site 714359002635 ABC-ATPase subunit interface; other site 714359002636 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 714359002637 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714359002638 Walker A/P-loop; other site 714359002639 ATP binding site [chemical binding]; other site 714359002640 Q-loop/lid; other site 714359002641 ABC transporter signature motif; other site 714359002642 Walker B; other site 714359002643 D-loop; other site 714359002644 H-loop/switch region; other site 714359002645 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 714359002646 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 714359002647 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714359002648 Walker A/P-loop; other site 714359002649 ATP binding site [chemical binding]; other site 714359002650 Q-loop/lid; other site 714359002651 ABC transporter signature motif; other site 714359002652 Walker B; other site 714359002653 D-loop; other site 714359002654 H-loop/switch region; other site 714359002655 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 714359002656 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 714359002657 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 714359002658 catalytic residues [active] 714359002659 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 714359002660 SnoaL-like domain; Region: SnoaL_2; pfam12680 714359002661 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 714359002662 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 714359002663 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359002664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359002665 non-specific DNA binding site [nucleotide binding]; other site 714359002666 salt bridge; other site 714359002667 sequence-specific DNA binding site [nucleotide binding]; other site 714359002668 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 714359002669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 714359002670 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 714359002671 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 714359002672 LXG domain of WXG superfamily; Region: LXG; pfam04740 714359002673 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 714359002674 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 714359002675 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 714359002676 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 714359002677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002678 putative substrate translocation pore; other site 714359002679 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 714359002680 PAS domain; Region: PAS; smart00091 714359002681 putative active site [active] 714359002682 heme pocket [chemical binding]; other site 714359002683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359002684 ATP binding site [chemical binding]; other site 714359002685 Mg2+ binding site [ion binding]; other site 714359002686 G-X-G motif; other site 714359002687 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 714359002688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359002689 active site 714359002690 phosphorylation site [posttranslational modification] 714359002691 intermolecular recognition site; other site 714359002692 dimerization interface [polypeptide binding]; other site 714359002693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 714359002694 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 714359002695 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 714359002696 cofactor binding site; other site 714359002697 DNA binding site [nucleotide binding] 714359002698 substrate interaction site [chemical binding]; other site 714359002699 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 714359002700 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 714359002701 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 714359002702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359002703 ATP binding site [chemical binding]; other site 714359002704 Mg2+ binding site [ion binding]; other site 714359002705 G-X-G motif; other site 714359002706 Z1 domain; Region: Z1; pfam10593 714359002707 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 714359002708 AIPR protein; Region: AIPR; pfam10592 714359002709 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 714359002710 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 714359002711 active site 714359002712 AIPR protein; Region: AIPR; pfam10592 714359002713 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 714359002714 replicative DNA helicase; Provisional; Region: PRK06749 714359002715 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 714359002716 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 714359002717 Walker A motif; other site 714359002718 ATP binding site [chemical binding]; other site 714359002719 Walker B motif; other site 714359002720 DNA binding loops [nucleotide binding] 714359002721 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 714359002722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359002723 non-specific DNA binding site [nucleotide binding]; other site 714359002724 salt bridge; other site 714359002725 sequence-specific DNA binding site [nucleotide binding]; other site 714359002726 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 714359002727 Restriction endonuclease; Region: Mrr_cat; pfam04471 714359002728 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 714359002729 Predicted transcriptional regulators [Transcription]; Region: COG1378 714359002730 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 714359002731 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 714359002732 C-terminal domain interface [polypeptide binding]; other site 714359002733 sugar binding site [chemical binding]; other site 714359002734 hypothetical protein; Provisional; Region: PRK10621 714359002735 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359002736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359002737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359002738 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359002739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002740 putative substrate translocation pore; other site 714359002741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002742 hypothetical protein; Provisional; Region: PRK06770 714359002743 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359002744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 714359002745 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359002746 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 714359002747 putative pectinesterase; Region: PLN02432; cl01911 714359002748 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 714359002749 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 714359002750 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 714359002751 CGNR zinc finger; Region: zf-CGNR; pfam11706 714359002752 HPP family; Region: HPP; pfam04982 714359002753 Transcriptional regulators [Transcription]; Region: MarR; COG1846 714359002754 MarR family; Region: MarR_2; pfam12802 714359002755 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 714359002756 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 714359002757 VanZ like family; Region: VanZ; pfam04892 714359002758 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 714359002759 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 714359002760 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 714359002761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359002762 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 714359002763 dihydroxyacetone kinase; Provisional; Region: PRK14479 714359002764 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 714359002765 DAK2 domain; Region: Dak2; pfam02734 714359002766 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359002767 non-specific DNA binding site [nucleotide binding]; other site 714359002768 salt bridge; other site 714359002769 sequence-specific DNA binding site [nucleotide binding]; other site 714359002770 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359002771 S-layer homology domain; Region: SLH; pfam00395 714359002772 S-layer homology domain; Region: SLH; pfam00395 714359002773 S-layer homology domain; Region: SLH; pfam00395 714359002774 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 714359002775 hypothetical protein; Provisional; Region: PRK06770 714359002776 Putative zinc-finger; Region: zf-HC2; pfam13490 714359002777 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 714359002778 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 714359002779 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359002780 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359002781 DNA binding residues [nucleotide binding] 714359002782 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359002783 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 714359002784 Heat induced stress protein YflT; Region: YflT; pfam11181 714359002785 CsbD-like; Region: CsbD; pfam05532 714359002786 Predicted membrane protein [Function unknown]; Region: COG2261 714359002787 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 714359002788 anti sigma factor interaction site; other site 714359002789 regulatory phosphorylation site [posttranslational modification]; other site 714359002790 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 714359002791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359002792 ATP binding site [chemical binding]; other site 714359002793 Mg2+ binding site [ion binding]; other site 714359002794 G-X-G motif; other site 714359002795 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 714359002796 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359002797 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 714359002798 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359002799 DNA binding residues [nucleotide binding] 714359002800 Ferritin-like domain; Region: Ferritin; pfam00210 714359002801 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 714359002802 dinuclear metal binding motif [ion binding]; other site 714359002803 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 714359002804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359002805 active site 714359002806 phosphorylation site [posttranslational modification] 714359002807 intermolecular recognition site; other site 714359002808 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 714359002809 dimerization interface [polypeptide binding]; other site 714359002810 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 714359002811 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 714359002812 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 714359002813 CHASE3 domain; Region: CHASE3; pfam05227 714359002814 GAF domain; Region: GAF; pfam01590 714359002815 GAF domain; Region: GAF_2; pfam13185 714359002816 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359002817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359002818 dimer interface [polypeptide binding]; other site 714359002819 phosphorylation site [posttranslational modification] 714359002820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359002821 ATP binding site [chemical binding]; other site 714359002822 Mg2+ binding site [ion binding]; other site 714359002823 G-X-G motif; other site 714359002824 Response regulator receiver domain; Region: Response_reg; pfam00072 714359002825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359002826 active site 714359002827 phosphorylation site [posttranslational modification] 714359002828 intermolecular recognition site; other site 714359002829 dimerization interface [polypeptide binding]; other site 714359002830 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 714359002831 hypothetical protein; Provisional; Region: PRK12856 714359002832 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714359002833 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 714359002834 NADP binding site [chemical binding]; other site 714359002835 dimer interface [polypeptide binding]; other site 714359002836 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 714359002837 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 714359002838 active site 714359002839 YhzD-like protein; Region: YhzD; pfam14120 714359002840 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 714359002841 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359002842 active site 714359002843 metal binding site [ion binding]; metal-binding site 714359002844 AAA domain; Region: AAA_27; pfam13514 714359002845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359002846 Q-loop/lid; other site 714359002847 ABC transporter signature motif; other site 714359002848 Walker B; other site 714359002849 D-loop; other site 714359002850 H-loop/switch region; other site 714359002851 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 714359002852 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 714359002853 generic binding surface I; other site 714359002854 generic binding surface II; other site 714359002855 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359002856 Zn2+ binding site [ion binding]; other site 714359002857 Mg2+ binding site [ion binding]; other site 714359002858 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 714359002859 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359002860 Zn binding site [ion binding]; other site 714359002861 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 714359002862 Zn binding site [ion binding]; other site 714359002863 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 714359002864 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359002865 Zn binding site [ion binding]; other site 714359002866 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 714359002867 Zn binding site [ion binding]; other site 714359002868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 714359002869 TPR motif; other site 714359002870 binding surface 714359002871 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359002872 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 714359002873 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 714359002874 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 714359002875 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 714359002876 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 714359002877 Cupin; Region: Cupin_1; smart00835 714359002878 Cupin; Region: Cupin_1; smart00835 714359002879 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 714359002880 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 714359002881 amphipathic channel; other site 714359002882 Asn-Pro-Ala signature motifs; other site 714359002883 glycerol kinase; Provisional; Region: glpK; PRK00047 714359002884 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 714359002885 N- and C-terminal domain interface [polypeptide binding]; other site 714359002886 active site 714359002887 MgATP binding site [chemical binding]; other site 714359002888 catalytic site [active] 714359002889 metal binding site [ion binding]; metal-binding site 714359002890 glycerol binding site [chemical binding]; other site 714359002891 homotetramer interface [polypeptide binding]; other site 714359002892 homodimer interface [polypeptide binding]; other site 714359002893 FBP binding site [chemical binding]; other site 714359002894 protein IIAGlc interface [polypeptide binding]; other site 714359002895 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 714359002896 Predicted transcriptional regulators [Transcription]; Region: COG1695 714359002897 Transcriptional regulator PadR-like family; Region: PadR; cl17335 714359002898 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 714359002899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359002900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359002901 DNA binding residues [nucleotide binding] 714359002902 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 714359002903 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 714359002904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359002905 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 714359002906 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 714359002907 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 714359002908 Part of AAA domain; Region: AAA_19; pfam13245 714359002909 Family description; Region: UvrD_C_2; pfam13538 714359002910 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 714359002911 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 714359002912 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 714359002913 transcriptional regulator Hpr; Provisional; Region: PRK13777 714359002914 MarR family; Region: MarR; pfam01047 714359002915 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 714359002916 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 714359002917 HIT family signature motif; other site 714359002918 catalytic residue [active] 714359002919 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714359002920 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714359002921 Walker A/P-loop; other site 714359002922 ATP binding site [chemical binding]; other site 714359002923 Q-loop/lid; other site 714359002924 ABC transporter signature motif; other site 714359002925 Walker B; other site 714359002926 D-loop; other site 714359002927 H-loop/switch region; other site 714359002928 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 714359002929 EcsC protein family; Region: EcsC; pfam12787 714359002930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359002931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359002932 Uncharacterized conserved protein [Function unknown]; Region: COG3402 714359002933 Predicted membrane protein [Function unknown]; Region: COG3428 714359002934 Bacterial PH domain; Region: DUF304; pfam03703 714359002935 Bacterial PH domain; Region: DUF304; cl01348 714359002936 Bacterial PH domain; Region: DUF304; pfam03703 714359002937 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 714359002938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359002939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359002940 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359002941 EamA-like transporter family; Region: EamA; pfam00892 714359002942 EamA-like transporter family; Region: EamA; cl17759 714359002943 Uncharacterized conserved protein [Function unknown]; Region: COG3402 714359002944 Predicted membrane protein [Function unknown]; Region: COG3428 714359002945 Bacterial PH domain; Region: DUF304; pfam03703 714359002946 Bacterial PH domain; Region: DUF304; pfam03703 714359002947 Bacterial PH domain; Region: DUF304; pfam03703 714359002948 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 714359002949 Transglycosylase; Region: Transgly; pfam00912 714359002950 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 714359002951 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359002952 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 714359002953 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 714359002954 substrate binding site [chemical binding]; other site 714359002955 active site 714359002956 ferrochelatase; Provisional; Region: PRK12435 714359002957 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 714359002958 C-terminal domain interface [polypeptide binding]; other site 714359002959 active site 714359002960 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 714359002961 active site 714359002962 N-terminal domain interface [polypeptide binding]; other site 714359002963 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 714359002964 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 714359002965 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714359002966 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 714359002967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 714359002968 Fn3 associated; Region: Fn3_assoc; pfam13287 714359002969 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 714359002970 generic binding surface I; other site 714359002971 generic binding surface II; other site 714359002972 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 714359002973 putative active site [active] 714359002974 putative catalytic site [active] 714359002975 putative Mg binding site IVb [ion binding]; other site 714359002976 putative phosphate binding site [ion binding]; other site 714359002977 putative DNA binding site [nucleotide binding]; other site 714359002978 putative Mg binding site IVa [ion binding]; other site 714359002979 Penicillinase repressor; Region: Pencillinase_R; pfam03965 714359002980 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 714359002981 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359002982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359002983 Predicted membrane protein [Function unknown]; Region: COG1511 714359002984 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 714359002985 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 714359002986 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 714359002987 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 714359002988 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 714359002989 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 714359002990 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 714359002991 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359002992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359002993 Coenzyme A binding pocket [chemical binding]; other site 714359002994 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359002995 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359002996 DNA binding site [nucleotide binding] 714359002997 domain linker motif; other site 714359002998 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 714359002999 putative dimerization interface [polypeptide binding]; other site 714359003000 putative ligand binding site [chemical binding]; other site 714359003001 YhfH-like protein; Region: YhfH; pfam14149 714359003002 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 714359003003 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 714359003004 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 714359003005 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 714359003006 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 714359003007 active site 714359003008 CoA binding site [chemical binding]; other site 714359003009 AMP binding site [chemical binding]; other site 714359003010 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 714359003011 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359003012 substrate binding pocket [chemical binding]; other site 714359003013 membrane-bound complex binding site; other site 714359003014 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 714359003015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359003016 dimer interface [polypeptide binding]; other site 714359003017 conserved gate region; other site 714359003018 putative PBP binding loops; other site 714359003019 ABC-ATPase subunit interface; other site 714359003020 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 714359003021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359003022 dimer interface [polypeptide binding]; other site 714359003023 conserved gate region; other site 714359003024 putative PBP binding loops; other site 714359003025 ABC-ATPase subunit interface; other site 714359003026 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 714359003027 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 714359003028 Walker A/P-loop; other site 714359003029 ATP binding site [chemical binding]; other site 714359003030 Q-loop/lid; other site 714359003031 ABC transporter signature motif; other site 714359003032 Walker B; other site 714359003033 D-loop; other site 714359003034 H-loop/switch region; other site 714359003035 TOBE-like domain; Region: TOBE_3; pfam12857 714359003036 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 714359003037 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 714359003038 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 714359003039 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 714359003040 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 714359003041 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359003042 putative active site [active] 714359003043 putative metal binding site [ion binding]; other site 714359003044 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 714359003045 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359003046 Zn2+ binding site [ion binding]; other site 714359003047 Mg2+ binding site [ion binding]; other site 714359003048 Putative zinc-finger; Region: zf-HC2; pfam13490 714359003049 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 714359003050 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 714359003051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359003052 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714359003053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359003054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 714359003055 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359003056 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 714359003057 active site 714359003058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359003059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359003060 dimer interface [polypeptide binding]; other site 714359003061 phosphorylation site [posttranslational modification] 714359003062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003063 ATP binding site [chemical binding]; other site 714359003064 Mg2+ binding site [ion binding]; other site 714359003065 G-X-G motif; other site 714359003066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359003067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359003068 active site 714359003069 phosphorylation site [posttranslational modification] 714359003070 intermolecular recognition site; other site 714359003071 dimerization interface [polypeptide binding]; other site 714359003072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359003073 DNA binding site [nucleotide binding] 714359003074 CAAX protease self-immunity; Region: Abi; pfam02517 714359003075 Peptidase family M48; Region: Peptidase_M48; pfam01435 714359003076 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 714359003077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359003078 dimerization interface [polypeptide binding]; other site 714359003079 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359003080 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359003081 dimer interface [polypeptide binding]; other site 714359003082 putative CheW interface [polypeptide binding]; other site 714359003083 S-layer homology domain; Region: SLH; pfam00395 714359003084 S-layer homology domain; Region: SLH; pfam00395 714359003085 S-layer homology domain; Region: SLH; pfam00395 714359003086 S-layer homology domain; Region: SLH; pfam00395 714359003087 S-layer homology domain; Region: SLH; pfam00395 714359003088 S-layer homology domain; Region: SLH; pfam00395 714359003089 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 714359003090 active site 714359003091 isocitrate lyase; Provisional; Region: PRK15063 714359003092 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 714359003093 tetramer interface [polypeptide binding]; other site 714359003094 active site 714359003095 Mg2+/Mn2+ binding site [ion binding]; other site 714359003096 Phosphotransferase enzyme family; Region: APH; pfam01636 714359003097 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 714359003098 active site 714359003099 substrate binding site [chemical binding]; other site 714359003100 ATP binding site [chemical binding]; other site 714359003101 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714359003102 DNA-binding site [nucleotide binding]; DNA binding site 714359003103 RNA-binding motif; other site 714359003104 ComK protein; Region: ComK; pfam06338 714359003105 Uncharacterized conserved protein [Function unknown]; Region: COG0398 714359003106 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 714359003107 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714359003108 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359003109 Catalytic site [active] 714359003110 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359003111 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 714359003112 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 714359003113 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 714359003114 Part of AAA domain; Region: AAA_19; pfam13245 714359003115 Family description; Region: UvrD_C_2; pfam13538 714359003116 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 714359003117 hypothetical protein; Provisional; Region: PRK07758 714359003118 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 714359003119 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 714359003120 Spore germination protein GerPC; Region: GerPC; pfam10737 714359003121 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 714359003122 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 714359003123 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 714359003124 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 714359003125 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359003126 inhibitor-cofactor binding pocket; inhibition site 714359003127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359003128 catalytic residue [active] 714359003129 hypothetical protein; Provisional; Region: PRK13673 714359003130 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 714359003131 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 714359003132 active site 714359003133 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 714359003134 dimer interface [polypeptide binding]; other site 714359003135 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 714359003136 Ligand Binding Site [chemical binding]; other site 714359003137 Molecular Tunnel; other site 714359003138 ferrochelatase; Provisional; Region: PRK12435 714359003139 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 714359003140 C-terminal domain interface [polypeptide binding]; other site 714359003141 active site 714359003142 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 714359003143 active site 714359003144 N-terminal domain interface [polypeptide binding]; other site 714359003145 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 714359003146 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 714359003147 tetramer interface [polypeptide binding]; other site 714359003148 heme binding pocket [chemical binding]; other site 714359003149 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 714359003150 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 714359003151 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 714359003152 active site 714359003153 catalytic site [active] 714359003154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359003155 non-specific DNA binding site [nucleotide binding]; other site 714359003156 salt bridge; other site 714359003157 sequence-specific DNA binding site [nucleotide binding]; other site 714359003158 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359003159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 714359003160 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 714359003161 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 714359003162 S1 domain; Region: S1_2; pfam13509 714359003163 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 714359003164 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 714359003165 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 714359003166 RHS Repeat; Region: RHS_repeat; cl11982 714359003167 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 714359003168 RHS protein; Region: RHS; pfam03527 714359003169 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 714359003170 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 714359003171 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 714359003172 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359003173 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359003174 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 714359003175 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 714359003176 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 714359003177 YjzC-like protein; Region: YjzC; pfam14168 714359003178 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 714359003179 Clp amino terminal domain; Region: Clp_N; pfam02861 714359003180 Clp amino terminal domain; Region: Clp_N; pfam02861 714359003181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359003182 Walker A motif; other site 714359003183 ATP binding site [chemical binding]; other site 714359003184 Walker B motif; other site 714359003185 arginine finger; other site 714359003186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359003187 Walker A motif; other site 714359003188 ATP binding site [chemical binding]; other site 714359003189 Walker B motif; other site 714359003190 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 714359003191 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 714359003192 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 714359003193 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 714359003194 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359003195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359003196 ComZ; Region: ComZ; pfam10815 714359003197 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 714359003198 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 714359003199 dimer interface [polypeptide binding]; other site 714359003200 active site 714359003201 CoA binding pocket [chemical binding]; other site 714359003202 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 714359003203 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 714359003204 dimer interface [polypeptide binding]; other site 714359003205 active site 714359003206 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 714359003207 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 714359003208 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 714359003209 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 714359003210 active site 714359003211 HIGH motif; other site 714359003212 dimer interface [polypeptide binding]; other site 714359003213 KMSKS motif; other site 714359003214 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359003215 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359003216 peptide binding site [polypeptide binding]; other site 714359003217 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 714359003218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359003219 dimer interface [polypeptide binding]; other site 714359003220 conserved gate region; other site 714359003221 putative PBP binding loops; other site 714359003222 ABC-ATPase subunit interface; other site 714359003223 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 714359003224 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 714359003225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359003226 dimer interface [polypeptide binding]; other site 714359003227 conserved gate region; other site 714359003228 putative PBP binding loops; other site 714359003229 ABC-ATPase subunit interface; other site 714359003230 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 714359003231 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714359003232 Walker A/P-loop; other site 714359003233 ATP binding site [chemical binding]; other site 714359003234 Q-loop/lid; other site 714359003235 ABC transporter signature motif; other site 714359003236 Walker B; other site 714359003237 D-loop; other site 714359003238 H-loop/switch region; other site 714359003239 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714359003240 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 714359003241 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714359003242 Walker A/P-loop; other site 714359003243 ATP binding site [chemical binding]; other site 714359003244 Q-loop/lid; other site 714359003245 ABC transporter signature motif; other site 714359003246 Walker B; other site 714359003247 D-loop; other site 714359003248 H-loop/switch region; other site 714359003249 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714359003250 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 714359003251 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 714359003252 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359003253 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359003254 peptide binding site [polypeptide binding]; other site 714359003255 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 714359003256 ArsC family; Region: ArsC; pfam03960 714359003257 putative catalytic residues [active] 714359003258 thiol/disulfide switch; other site 714359003259 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 714359003260 adaptor protein; Provisional; Region: PRK02315 714359003261 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 714359003262 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 714359003263 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 714359003264 putative active site [active] 714359003265 catalytic site [active] 714359003266 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 714359003267 putative active site [active] 714359003268 catalytic site [active] 714359003269 Competence protein CoiA-like family; Region: CoiA; cl11541 714359003270 oligoendopeptidase F; Region: pepF; TIGR00181 714359003271 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 714359003272 active site 714359003273 Zn binding site [ion binding]; other site 714359003274 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 714359003275 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 714359003276 catalytic residues [active] 714359003277 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 714359003278 apolar tunnel; other site 714359003279 heme binding site [chemical binding]; other site 714359003280 dimerization interface [polypeptide binding]; other site 714359003281 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 714359003282 putative active site [active] 714359003283 putative metal binding residues [ion binding]; other site 714359003284 signature motif; other site 714359003285 putative triphosphate binding site [ion binding]; other site 714359003286 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 714359003287 synthetase active site [active] 714359003288 NTP binding site [chemical binding]; other site 714359003289 metal binding site [ion binding]; metal-binding site 714359003290 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 714359003291 ATP-NAD kinase; Region: NAD_kinase; pfam01513 714359003292 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 714359003293 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 714359003294 active site 714359003295 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 714359003296 trimer interface [polypeptide binding]; other site 714359003297 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 714359003298 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 714359003299 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 714359003300 active site 714359003301 metal binding site [ion binding]; metal-binding site 714359003302 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 714359003303 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 714359003304 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359003305 active site 714359003306 Methyltransferase domain; Region: Methyltransf_23; pfam13489 714359003307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359003308 S-adenosylmethionine binding site [chemical binding]; other site 714359003309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 714359003310 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 714359003311 putative metal binding site; other site 714359003312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359003313 binding surface 714359003314 TPR motif; other site 714359003315 Methyltransferase domain; Region: Methyltransf_23; pfam13489 714359003316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359003317 S-adenosylmethionine binding site [chemical binding]; other site 714359003318 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 714359003319 catalytic residues [active] 714359003320 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 714359003321 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 714359003322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359003323 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 714359003324 active site 714359003325 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 714359003326 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 714359003327 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 714359003328 NAD binding site [chemical binding]; other site 714359003329 substrate binding site [chemical binding]; other site 714359003330 homodimer interface [polypeptide binding]; other site 714359003331 active site 714359003332 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 714359003333 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 714359003334 NADP binding site [chemical binding]; other site 714359003335 active site 714359003336 putative substrate binding site [chemical binding]; other site 714359003337 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 714359003338 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 714359003339 NAD binding site [chemical binding]; other site 714359003340 homotetramer interface [polypeptide binding]; other site 714359003341 homodimer interface [polypeptide binding]; other site 714359003342 substrate binding site [chemical binding]; other site 714359003343 active site 714359003344 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 714359003345 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 714359003346 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 714359003347 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 714359003348 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 714359003349 Part of AAA domain; Region: AAA_19; pfam13245 714359003350 Family description; Region: UvrD_C_2; pfam13538 714359003351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359003352 Coenzyme A binding pocket [chemical binding]; other site 714359003353 hypothetical protein; Provisional; Region: PRK13679 714359003354 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 714359003355 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 714359003356 Putative esterase; Region: Esterase; pfam00756 714359003357 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359003358 EamA-like transporter family; Region: EamA; pfam00892 714359003359 EamA-like transporter family; Region: EamA; pfam00892 714359003360 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 714359003361 Pectate lyase; Region: Pectate_lyase; pfam03211 714359003362 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 714359003363 Na binding site [ion binding]; other site 714359003364 anthranilate synthase component I; Provisional; Region: PRK13570 714359003365 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 714359003366 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 714359003367 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 714359003368 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 714359003369 glutamine binding [chemical binding]; other site 714359003370 catalytic triad [active] 714359003371 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 714359003372 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 714359003373 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 714359003374 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 714359003375 active site 714359003376 ribulose/triose binding site [chemical binding]; other site 714359003377 phosphate binding site [ion binding]; other site 714359003378 substrate (anthranilate) binding pocket [chemical binding]; other site 714359003379 product (indole) binding pocket [chemical binding]; other site 714359003380 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 714359003381 active site 714359003382 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 714359003383 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 714359003384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359003385 catalytic residue [active] 714359003386 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 714359003387 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 714359003388 substrate binding site [chemical binding]; other site 714359003389 active site 714359003390 catalytic residues [active] 714359003391 heterodimer interface [polypeptide binding]; other site 714359003392 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 714359003393 L-lactate permease; Region: Lactate_perm; cl00701 714359003394 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 714359003395 Predicted membrane protein [Function unknown]; Region: COG4640 714359003396 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 714359003397 YARHG domain; Region: YARHG; pfam13308 714359003398 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714359003399 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 714359003400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714359003401 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714359003402 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 714359003403 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 714359003404 NADPH bind site [chemical binding]; other site 714359003405 putative FMN binding site [chemical binding]; other site 714359003406 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 714359003407 putative FMN binding site [chemical binding]; other site 714359003408 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 714359003409 YcaO-like family; Region: YcaO; pfam02624 714359003410 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 714359003411 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 714359003412 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 714359003413 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 714359003414 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714359003415 E3 interaction surface; other site 714359003416 lipoyl attachment site [posttranslational modification]; other site 714359003417 e3 binding domain; Region: E3_binding; pfam02817 714359003418 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 714359003419 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 714359003420 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 714359003421 TPP-binding site [chemical binding]; other site 714359003422 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 714359003423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359003424 salt bridge; other site 714359003425 non-specific DNA binding site [nucleotide binding]; other site 714359003426 sequence-specific DNA binding site [nucleotide binding]; other site 714359003427 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 714359003428 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 714359003429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359003430 Walker A/P-loop; other site 714359003431 ATP binding site [chemical binding]; other site 714359003432 Q-loop/lid; other site 714359003433 ABC transporter signature motif; other site 714359003434 Walker B; other site 714359003435 D-loop; other site 714359003436 H-loop/switch region; other site 714359003437 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 714359003438 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 714359003439 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 714359003440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359003441 S-adenosylmethionine binding site [chemical binding]; other site 714359003442 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359003443 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714359003444 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 714359003445 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359003446 Catalytic site [active] 714359003447 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 714359003448 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 714359003449 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 714359003450 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359003451 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359003452 non-specific DNA binding site [nucleotide binding]; other site 714359003453 salt bridge; other site 714359003454 sequence-specific DNA binding site [nucleotide binding]; other site 714359003455 Anti-repressor SinI; Region: SinI; pfam08671 714359003456 Anti-repressor SinI; Region: SinI; pfam08671 714359003457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 714359003458 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 714359003459 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 714359003460 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 714359003461 NAD(P) binding site [chemical binding]; other site 714359003462 catalytic residues [active] 714359003463 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 714359003464 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 714359003465 Walker A/P-loop; other site 714359003466 ATP binding site [chemical binding]; other site 714359003467 Q-loop/lid; other site 714359003468 ABC transporter signature motif; other site 714359003469 Walker B; other site 714359003470 D-loop; other site 714359003471 H-loop/switch region; other site 714359003472 TOBE domain; Region: TOBE_2; pfam08402 714359003473 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 714359003474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359003475 dimer interface [polypeptide binding]; other site 714359003476 conserved gate region; other site 714359003477 putative PBP binding loops; other site 714359003478 ABC-ATPase subunit interface; other site 714359003479 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 714359003480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359003481 dimer interface [polypeptide binding]; other site 714359003482 conserved gate region; other site 714359003483 putative PBP binding loops; other site 714359003484 ABC-ATPase subunit interface; other site 714359003485 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 714359003486 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 714359003487 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 714359003488 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 714359003489 active site 714359003490 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 714359003491 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 714359003492 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 714359003493 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 714359003494 active site 714359003495 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 714359003496 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 714359003497 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 714359003498 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714359003499 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 714359003500 Cysteine-rich domain; Region: CCG; pfam02754 714359003501 Cysteine-rich domain; Region: CCG; pfam02754 714359003502 FAD binding domain; Region: FAD_binding_4; pfam01565 714359003503 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 714359003504 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 714359003505 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 714359003506 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 714359003507 metal binding site [ion binding]; metal-binding site 714359003508 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 714359003509 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 714359003510 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 714359003511 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 714359003512 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359003513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359003514 active site 714359003515 phosphorylation site [posttranslational modification] 714359003516 intermolecular recognition site; other site 714359003517 dimerization interface [polypeptide binding]; other site 714359003518 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359003519 DNA binding site [nucleotide binding] 714359003520 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 714359003521 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359003522 dimerization interface [polypeptide binding]; other site 714359003523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359003524 dimer interface [polypeptide binding]; other site 714359003525 phosphorylation site [posttranslational modification] 714359003526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003527 ATP binding site [chemical binding]; other site 714359003528 Mg2+ binding site [ion binding]; other site 714359003529 G-X-G motif; other site 714359003530 Transcriptional regulators [Transcription]; Region: FadR; COG2186 714359003531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359003532 DNA-binding site [nucleotide binding]; DNA binding site 714359003533 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 714359003534 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 714359003535 Cysteine-rich domain; Region: CCG; pfam02754 714359003536 Cysteine-rich domain; Region: CCG; pfam02754 714359003537 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 714359003538 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 714359003539 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 714359003540 Uncharacterized conserved protein [Function unknown]; Region: COG1556 714359003541 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 714359003542 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 714359003543 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 714359003544 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 714359003545 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 714359003546 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 714359003547 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 714359003548 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359003549 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 714359003550 dimer interaction site [polypeptide binding]; other site 714359003551 substrate-binding tunnel; other site 714359003552 active site 714359003553 catalytic site [active] 714359003554 substrate binding site [chemical binding]; other site 714359003555 polyhydroxyalkanoic acid inclusion protein PhaP; Region: phaP_Bmeg; TIGR02131 714359003556 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 714359003557 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 714359003558 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 714359003559 NAD(P) binding site [chemical binding]; other site 714359003560 homotetramer interface [polypeptide binding]; other site 714359003561 homodimer interface [polypeptide binding]; other site 714359003562 active site 714359003563 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 714359003564 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 714359003565 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 714359003566 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 714359003567 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 714359003568 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 714359003569 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 714359003570 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 714359003571 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 714359003572 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 714359003573 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 714359003574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359003575 Walker A/P-loop; other site 714359003576 ATP binding site [chemical binding]; other site 714359003577 Q-loop/lid; other site 714359003578 ABC transporter signature motif; other site 714359003579 Walker B; other site 714359003580 D-loop; other site 714359003581 H-loop/switch region; other site 714359003582 TOBE domain; Region: TOBE_2; pfam08402 714359003583 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 714359003584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359003585 dimer interface [polypeptide binding]; other site 714359003586 conserved gate region; other site 714359003587 putative PBP binding loops; other site 714359003588 ABC-ATPase subunit interface; other site 714359003589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359003590 dimer interface [polypeptide binding]; other site 714359003591 conserved gate region; other site 714359003592 putative PBP binding loops; other site 714359003593 ABC-ATPase subunit interface; other site 714359003594 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 714359003595 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359003596 motif II; other site 714359003597 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 714359003598 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359003599 catalytic residue [active] 714359003600 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 714359003601 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714359003602 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 714359003603 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714359003604 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359003605 heme-binding site [chemical binding]; other site 714359003606 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003607 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 714359003608 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003609 Leucine-rich repeats; other site 714359003610 Substrate binding site [chemical binding]; other site 714359003611 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003612 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003613 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003614 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003615 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003616 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003617 LRR adjacent; Region: LRR_adjacent; pfam08191 714359003618 S-layer homology domain; Region: SLH; pfam00395 714359003619 S-layer homology domain; Region: SLH; pfam00395 714359003620 S-layer homology domain; Region: SLH; pfam00395 714359003621 hypothetical protein; Validated; Region: PRK06755 714359003622 intersubunit interface [polypeptide binding]; other site 714359003623 active site 714359003624 Zn2+ binding site [ion binding]; other site 714359003625 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 714359003626 FOG: CBS domain [General function prediction only]; Region: COG0517 714359003627 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 714359003628 NodB motif; other site 714359003629 putative active site [active] 714359003630 putative catalytic site [active] 714359003631 Zn binding site [ion binding]; other site 714359003632 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 714359003633 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 714359003634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359003635 dimer interface [polypeptide binding]; other site 714359003636 phosphorylation site [posttranslational modification] 714359003637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003638 ATP binding site [chemical binding]; other site 714359003639 Mg2+ binding site [ion binding]; other site 714359003640 G-X-G motif; other site 714359003641 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359003642 MarR family; Region: MarR; pfam01047 714359003643 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 714359003644 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 714359003645 active site 714359003646 Zn binding site [ion binding]; other site 714359003647 DinB superfamily; Region: DinB_2; pfam12867 714359003648 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 714359003649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359003650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359003651 dimer interface [polypeptide binding]; other site 714359003652 phosphorylation site [posttranslational modification] 714359003653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003654 ATP binding site [chemical binding]; other site 714359003655 Mg2+ binding site [ion binding]; other site 714359003656 G-X-G motif; other site 714359003657 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 714359003658 Ligand Binding Site [chemical binding]; other site 714359003659 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 714359003660 active site 714359003661 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 714359003662 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 714359003663 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 714359003664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359003665 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359003666 Coenzyme A binding pocket [chemical binding]; other site 714359003667 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 714359003668 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 714359003669 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 714359003670 Class I ribonucleotide reductase; Region: RNR_I; cd01679 714359003671 active site 714359003672 dimer interface [polypeptide binding]; other site 714359003673 catalytic residues [active] 714359003674 effector binding site; other site 714359003675 R2 peptide binding site; other site 714359003676 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 714359003677 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 714359003678 dimer interface [polypeptide binding]; other site 714359003679 putative radical transfer pathway; other site 714359003680 diiron center [ion binding]; other site 714359003681 tyrosyl radical; other site 714359003682 Predicted transcriptional regulators [Transcription]; Region: COG1725 714359003683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359003684 DNA-binding site [nucleotide binding]; DNA binding site 714359003685 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 714359003686 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714359003687 Walker A/P-loop; other site 714359003688 ATP binding site [chemical binding]; other site 714359003689 Q-loop/lid; other site 714359003690 ABC transporter signature motif; other site 714359003691 Walker B; other site 714359003692 D-loop; other site 714359003693 H-loop/switch region; other site 714359003694 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359003695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359003696 Walker A/P-loop; other site 714359003697 ATP binding site [chemical binding]; other site 714359003698 Q-loop/lid; other site 714359003699 ABC transporter signature motif; other site 714359003700 Walker B; other site 714359003701 D-loop; other site 714359003702 H-loop/switch region; other site 714359003703 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 714359003704 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 714359003705 CAAX protease self-immunity; Region: Abi; pfam02517 714359003706 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 714359003707 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 714359003708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359003709 putative DNA binding site [nucleotide binding]; other site 714359003710 putative Zn2+ binding site [ion binding]; other site 714359003711 AsnC family; Region: AsnC_trans_reg; pfam01037 714359003712 Uncharacterized conserved protein [Function unknown]; Region: COG2128 714359003713 Isochorismatase family; Region: Isochorismatase; pfam00857 714359003714 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 714359003715 catalytic triad [active] 714359003716 conserved cis-peptide bond; other site 714359003717 SseB protein; Region: SseB; cl06279 714359003718 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 714359003719 dimer interface [polypeptide binding]; other site 714359003720 catalytic triad [active] 714359003721 Nitronate monooxygenase; Region: NMO; pfam03060 714359003722 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 714359003723 FMN binding site [chemical binding]; other site 714359003724 substrate binding site [chemical binding]; other site 714359003725 putative catalytic residue [active] 714359003726 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 714359003727 DltD N-terminal region; Region: DltD_N; pfam04915 714359003728 DltD central region; Region: DltD_M; pfam04918 714359003729 DltD C-terminal region; Region: DltD_C; pfam04914 714359003730 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 714359003731 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 714359003732 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 714359003733 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 714359003734 acyl-activating enzyme (AAE) consensus motif; other site 714359003735 AMP binding site [chemical binding]; other site 714359003736 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 714359003737 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 714359003738 metal binding site [ion binding]; metal-binding site 714359003739 dimer interface [polypeptide binding]; other site 714359003740 flavodoxin; Provisional; Region: PRK06756 714359003741 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 714359003742 Phosphotransferase enzyme family; Region: APH; pfam01636 714359003743 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 714359003744 active site 714359003745 substrate binding site [chemical binding]; other site 714359003746 ATP binding site [chemical binding]; other site 714359003747 multidrug efflux protein; Reviewed; Region: PRK01766 714359003748 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 714359003749 cation binding site [ion binding]; other site 714359003750 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 714359003751 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 714359003752 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359003753 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 714359003754 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 714359003755 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 714359003756 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 714359003757 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 714359003758 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 714359003759 hypothetical protein; Provisional; Region: PRK03094 714359003760 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 714359003761 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 714359003762 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 714359003763 homodimer interface [polypeptide binding]; other site 714359003764 substrate-cofactor binding pocket; other site 714359003765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359003766 catalytic residue [active] 714359003767 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 714359003768 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 714359003769 PYR/PP interface [polypeptide binding]; other site 714359003770 dimer interface [polypeptide binding]; other site 714359003771 TPP binding site [chemical binding]; other site 714359003772 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 714359003773 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 714359003774 TPP-binding site [chemical binding]; other site 714359003775 dimer interface [polypeptide binding]; other site 714359003776 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 714359003777 ketol-acid reductoisomerase; Provisional; Region: PRK05479 714359003778 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 714359003779 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 714359003780 2-isopropylmalate synthase; Validated; Region: PRK00915 714359003781 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 714359003782 active site 714359003783 catalytic residues [active] 714359003784 metal binding site [ion binding]; metal-binding site 714359003785 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 714359003786 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 714359003787 tartrate dehydrogenase; Region: TTC; TIGR02089 714359003788 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 714359003789 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 714359003790 substrate binding site [chemical binding]; other site 714359003791 ligand binding site [chemical binding]; other site 714359003792 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 714359003793 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 714359003794 substrate binding site [chemical binding]; other site 714359003795 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 714359003796 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 714359003797 dimer interface [polypeptide binding]; other site 714359003798 motif 1; other site 714359003799 active site 714359003800 motif 2; other site 714359003801 motif 3; other site 714359003802 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 714359003803 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 714359003804 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 714359003805 histidinol dehydrogenase; Region: hisD; TIGR00069 714359003806 NAD binding site [chemical binding]; other site 714359003807 dimerization interface [polypeptide binding]; other site 714359003808 product binding site; other site 714359003809 substrate binding site [chemical binding]; other site 714359003810 zinc binding site [ion binding]; other site 714359003811 catalytic residues [active] 714359003812 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 714359003813 putative active site pocket [active] 714359003814 4-fold oligomerization interface [polypeptide binding]; other site 714359003815 metal binding residues [ion binding]; metal-binding site 714359003816 3-fold/trimer interface [polypeptide binding]; other site 714359003817 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 714359003818 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 714359003819 catalytic residues [active] 714359003820 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 714359003821 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 714359003822 substrate binding site [chemical binding]; other site 714359003823 glutamase interaction surface [polypeptide binding]; other site 714359003824 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 714359003825 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 714359003826 metal binding site [ion binding]; metal-binding site 714359003827 histidinol-phosphatase; Validated; Region: PRK06740 714359003828 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 714359003829 dimer interface [polypeptide binding]; other site 714359003830 active site 714359003831 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 714359003832 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 714359003833 putative ligand binding site [chemical binding]; other site 714359003834 putative NAD binding site [chemical binding]; other site 714359003835 catalytic site [active] 714359003836 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 714359003837 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 714359003838 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 714359003839 Sulfatase; Region: Sulfatase; pfam00884 714359003840 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 714359003841 diaminopimelate decarboxylase; Region: lysA; TIGR01048 714359003842 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 714359003843 active site 714359003844 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714359003845 substrate binding site [chemical binding]; other site 714359003846 catalytic residues [active] 714359003847 dimer interface [polypeptide binding]; other site 714359003848 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 714359003849 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 714359003850 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 714359003851 Active Sites [active] 714359003852 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 714359003853 ATP-sulfurylase; Region: ATPS; cd00517 714359003854 active site 714359003855 HXXH motif; other site 714359003856 flexible loop; other site 714359003857 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 714359003858 AAA domain; Region: AAA_18; pfam13238 714359003859 ligand-binding site [chemical binding]; other site 714359003860 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 714359003861 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 714359003862 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 714359003863 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 714359003864 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 714359003865 active site 714359003866 SAM binding site [chemical binding]; other site 714359003867 homodimer interface [polypeptide binding]; other site 714359003868 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 714359003869 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 714359003870 putative active site [active] 714359003871 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 714359003872 putative active site [active] 714359003873 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 714359003874 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 714359003875 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 714359003876 Na2 binding site [ion binding]; other site 714359003877 putative substrate binding site 1 [chemical binding]; other site 714359003878 Na binding site 1 [ion binding]; other site 714359003879 putative substrate binding site 2 [chemical binding]; other site 714359003880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 714359003881 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 714359003882 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359003883 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 714359003884 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 714359003885 Protein of unknown function (DUF402); Region: DUF402; cl00979 714359003886 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 714359003887 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 714359003888 Vpu protein; Region: Vpu; pfam00558 714359003889 PspA/IM30 family; Region: PspA_IM30; pfam04012 714359003890 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 714359003891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 714359003892 Histidine kinase; Region: HisKA_3; pfam07730 714359003893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003894 ATP binding site [chemical binding]; other site 714359003895 Mg2+ binding site [ion binding]; other site 714359003896 G-X-G motif; other site 714359003897 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359003898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359003899 active site 714359003900 phosphorylation site [posttranslational modification] 714359003901 intermolecular recognition site; other site 714359003902 dimerization interface [polypeptide binding]; other site 714359003903 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359003904 DNA binding residues [nucleotide binding] 714359003905 dimerization interface [polypeptide binding]; other site 714359003906 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714359003907 E3 interaction surface; other site 714359003908 lipoyl attachment site [posttranslational modification]; other site 714359003909 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 714359003910 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 714359003911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359003912 S-adenosylmethionine binding site [chemical binding]; other site 714359003913 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 714359003914 Peptidase family M50; Region: Peptidase_M50; pfam02163 714359003915 active site 714359003916 putative substrate binding region [chemical binding]; other site 714359003917 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 714359003918 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 714359003919 heme-binding site [chemical binding]; other site 714359003920 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 714359003921 FAD binding pocket [chemical binding]; other site 714359003922 FAD binding motif [chemical binding]; other site 714359003923 phosphate binding motif [ion binding]; other site 714359003924 beta-alpha-beta structure motif; other site 714359003925 NAD binding pocket [chemical binding]; other site 714359003926 Heme binding pocket [chemical binding]; other site 714359003927 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 714359003928 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714359003929 ligand binding site [chemical binding]; other site 714359003930 flexible hinge region; other site 714359003931 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 714359003932 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359003933 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 714359003934 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 714359003935 Transglycosylase; Region: Transgly; pfam00912 714359003936 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 714359003937 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359003938 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 714359003939 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 714359003940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359003941 putative active site [active] 714359003942 heme pocket [chemical binding]; other site 714359003943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359003944 dimer interface [polypeptide binding]; other site 714359003945 phosphorylation site [posttranslational modification] 714359003946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003947 ATP binding site [chemical binding]; other site 714359003948 Mg2+ binding site [ion binding]; other site 714359003949 G-X-G motif; other site 714359003950 Protein of unknown function DUF72; Region: DUF72; pfam01904 714359003951 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 714359003952 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714359003953 active site 714359003954 DNA binding site [nucleotide binding] 714359003955 Int/Topo IB signature motif; other site 714359003956 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359003957 dimerization interface [polypeptide binding]; other site 714359003958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359003959 dimer interface [polypeptide binding]; other site 714359003960 phosphorylation site [posttranslational modification] 714359003961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003962 ATP binding site [chemical binding]; other site 714359003963 Mg2+ binding site [ion binding]; other site 714359003964 G-X-G motif; other site 714359003965 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 714359003966 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 714359003967 Predicted integral membrane protein [Function unknown]; Region: COG0392 714359003968 Uncharacterized conserved protein [Function unknown]; Region: COG2898 714359003969 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 714359003970 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 714359003971 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 714359003972 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 714359003973 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 714359003974 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714359003975 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359003976 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 714359003977 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 714359003978 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 714359003979 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359003980 RNA binding surface [nucleotide binding]; other site 714359003981 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 714359003982 active site 714359003983 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 714359003984 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 714359003985 catalytic residues [active] 714359003986 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 714359003987 ResB-like family; Region: ResB; pfam05140 714359003988 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 714359003989 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 714359003990 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359003991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359003992 active site 714359003993 phosphorylation site [posttranslational modification] 714359003994 intermolecular recognition site; other site 714359003995 dimerization interface [polypeptide binding]; other site 714359003996 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359003997 DNA binding site [nucleotide binding] 714359003998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 714359003999 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359004000 dimerization interface [polypeptide binding]; other site 714359004001 PAS domain; Region: PAS; smart00091 714359004002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359004003 dimer interface [polypeptide binding]; other site 714359004004 phosphorylation site [posttranslational modification] 714359004005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359004006 ATP binding site [chemical binding]; other site 714359004007 Mg2+ binding site [ion binding]; other site 714359004008 G-X-G motif; other site 714359004009 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 714359004010 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 714359004011 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359004012 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 714359004013 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714359004014 Predicted membrane protein [Function unknown]; Region: COG3601 714359004015 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 714359004016 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 714359004017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 714359004018 DEAD-like helicases superfamily; Region: DEXDc; smart00487 714359004019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359004020 ATP binding site [chemical binding]; other site 714359004021 putative Mg++ binding site [ion binding]; other site 714359004022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359004023 nucleotide binding region [chemical binding]; other site 714359004024 ATP-binding site [chemical binding]; other site 714359004025 CAAX protease self-immunity; Region: Abi; pfam02517 714359004026 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714359004027 phosphodiesterase YaeI; Provisional; Region: PRK11340 714359004028 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 714359004029 putative active site [active] 714359004030 putative metal binding site [ion binding]; other site 714359004031 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 714359004032 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 714359004033 DNA binding residues [nucleotide binding] 714359004034 B12 binding domain; Region: B12-binding_2; pfam02607 714359004035 adaptor protein; Provisional; Region: PRK02899 714359004036 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 714359004037 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 714359004038 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 714359004039 NAD(P) binding site [chemical binding]; other site 714359004040 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 714359004041 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 714359004042 amidase catalytic site [active] 714359004043 Zn binding residues [ion binding]; other site 714359004044 substrate binding site [chemical binding]; other site 714359004045 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 714359004046 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 714359004047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714359004048 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 714359004049 active site 714359004050 homodimer interface [polypeptide binding]; other site 714359004051 homotetramer interface [polypeptide binding]; other site 714359004052 cytidylate kinase; Provisional; Region: cmk; PRK00023 714359004053 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 714359004054 CMP-binding site; other site 714359004055 The sites determining sugar specificity; other site 714359004056 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 714359004057 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 714359004058 RNA binding site [nucleotide binding]; other site 714359004059 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 714359004060 RNA binding site [nucleotide binding]; other site 714359004061 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 714359004062 RNA binding site [nucleotide binding]; other site 714359004063 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 714359004064 RNA binding site [nucleotide binding]; other site 714359004065 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 714359004066 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 714359004067 FMN binding site [chemical binding]; other site 714359004068 homodimer contacts [polypeptide binding]; other site 714359004069 putative active site [active] 714359004070 putative substrate binding site [chemical binding]; other site 714359004071 homotetramer interface [polypeptide binding]; other site 714359004072 YpzI-like protein; Region: YpzI; pfam14140 714359004073 YIEGIA protein; Region: YIEGIA; pfam14045 714359004074 GTP-binding protein Der; Reviewed; Region: PRK00093 714359004075 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 714359004076 G1 box; other site 714359004077 GTP/Mg2+ binding site [chemical binding]; other site 714359004078 Switch I region; other site 714359004079 G2 box; other site 714359004080 Switch II region; other site 714359004081 G3 box; other site 714359004082 G4 box; other site 714359004083 G5 box; other site 714359004084 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 714359004085 G1 box; other site 714359004086 GTP/Mg2+ binding site [chemical binding]; other site 714359004087 Switch I region; other site 714359004088 G2 box; other site 714359004089 G3 box; other site 714359004090 Switch II region; other site 714359004091 G4 box; other site 714359004092 G5 box; other site 714359004093 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 714359004094 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 714359004095 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 714359004096 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 714359004097 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 714359004098 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 714359004099 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 714359004100 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 714359004101 IHF dimer interface [polypeptide binding]; other site 714359004102 IHF - DNA interface [nucleotide binding]; other site 714359004103 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 714359004104 homodecamer interface [polypeptide binding]; other site 714359004105 GTP cyclohydrolase I; Provisional; Region: PLN03044 714359004106 active site 714359004107 putative catalytic site residues [active] 714359004108 zinc binding site [ion binding]; other site 714359004109 GTP-CH-I/GFRP interaction surface; other site 714359004110 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 714359004111 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 714359004112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359004113 S-adenosylmethionine binding site [chemical binding]; other site 714359004114 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 714359004115 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 714359004116 substrate binding pocket [chemical binding]; other site 714359004117 chain length determination region; other site 714359004118 substrate-Mg2+ binding site; other site 714359004119 catalytic residues [active] 714359004120 aspartate-rich region 1; other site 714359004121 active site lid residues [active] 714359004122 aspartate-rich region 2; other site 714359004123 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 714359004124 active site 714359004125 multimer interface [polypeptide binding]; other site 714359004126 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 714359004127 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 714359004128 Tetramer interface [polypeptide binding]; other site 714359004129 active site 714359004130 FMN-binding site [chemical binding]; other site 714359004131 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 714359004132 active site 714359004133 dimer interface [polypeptide binding]; other site 714359004134 metal binding site [ion binding]; metal-binding site 714359004135 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 714359004136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359004137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359004138 homodimer interface [polypeptide binding]; other site 714359004139 catalytic residue [active] 714359004140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359004141 binding surface 714359004142 TPR motif; other site 714359004143 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 714359004144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359004145 binding surface 714359004146 TPR motif; other site 714359004147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359004148 binding surface 714359004149 TPR motif; other site 714359004150 hypothetical protein; Provisional; Region: PRK03636 714359004151 UPF0302 domain; Region: UPF0302; pfam08864 714359004152 IDEAL domain; Region: IDEAL; pfam08858 714359004153 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 714359004154 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 714359004155 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 714359004156 iron-sulfur cluster [ion binding]; other site 714359004157 [2Fe-2S] cluster binding site [ion binding]; other site 714359004158 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 714359004159 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 714359004160 interchain domain interface [polypeptide binding]; other site 714359004161 intrachain domain interface; other site 714359004162 heme bH binding site [chemical binding]; other site 714359004163 Qi binding site; other site 714359004164 heme bL binding site [chemical binding]; other site 714359004165 Qo binding site; other site 714359004166 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 714359004167 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 714359004168 interchain domain interface [polypeptide binding]; other site 714359004169 intrachain domain interface; other site 714359004170 Qi binding site; other site 714359004171 Qo binding site; other site 714359004172 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 714359004173 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 714359004174 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 714359004175 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 714359004176 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 714359004177 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 714359004178 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 714359004179 active site 714359004180 Fe-S cluster binding site [ion binding]; other site 714359004181 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359004182 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359004183 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359004184 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 714359004185 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 714359004186 homodimer interface [polypeptide binding]; other site 714359004187 metal binding site [ion binding]; metal-binding site 714359004188 dihydrodipicolinate reductase; Provisional; Region: PRK00048 714359004189 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 714359004190 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 714359004191 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 714359004192 active site 714359004193 dimer interfaces [polypeptide binding]; other site 714359004194 catalytic residues [active] 714359004195 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 714359004196 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 714359004197 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 714359004198 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 714359004199 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 714359004200 active site 714359004201 NTP binding site [chemical binding]; other site 714359004202 metal binding triad [ion binding]; metal-binding site 714359004203 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 714359004204 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 714359004205 HTH domain; Region: HTH_11; cl17392 714359004206 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 714359004207 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 714359004208 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 714359004209 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 714359004210 oligomerization interface [polypeptide binding]; other site 714359004211 active site 714359004212 metal binding site [ion binding]; metal-binding site 714359004213 pantoate--beta-alanine ligase; Region: panC; TIGR00018 714359004214 Pantoate-beta-alanine ligase; Region: PanC; cd00560 714359004215 active site 714359004216 ATP-binding site [chemical binding]; other site 714359004217 pantoate-binding site; other site 714359004218 HXXH motif; other site 714359004219 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 714359004220 tetramerization interface [polypeptide binding]; other site 714359004221 active site 714359004222 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 714359004223 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 714359004224 active site 714359004225 catalytic site [active] 714359004226 substrate binding site [chemical binding]; other site 714359004227 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 714359004228 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 714359004229 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 714359004230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 714359004231 aspartate aminotransferase; Provisional; Region: PRK05764 714359004232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359004233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359004234 homodimer interface [polypeptide binding]; other site 714359004235 catalytic residue [active] 714359004236 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 714359004237 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 714359004238 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 714359004239 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 714359004240 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 714359004241 minor groove reading motif; other site 714359004242 helix-hairpin-helix signature motif; other site 714359004243 substrate binding pocket [chemical binding]; other site 714359004244 active site 714359004245 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 714359004246 Transglycosylase; Region: Transgly; pfam00912 714359004247 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359004248 Fibronectin type III domain; Region: fn3; pfam00041 714359004249 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 714359004250 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 714359004251 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 714359004252 YppG-like protein; Region: YppG; pfam14179 714359004253 hypothetical protein; Provisional; Region: PRK13660 714359004254 cell division protein GpsB; Provisional; Region: PRK14127 714359004255 DivIVA domain; Region: DivI1A_domain; TIGR03544 714359004256 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 714359004257 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 714359004258 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 714359004259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359004260 TPR motif; other site 714359004261 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359004262 binding surface 714359004263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359004264 TPR motif; other site 714359004265 binding surface 714359004266 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 714359004267 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 714359004268 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 714359004269 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 714359004270 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 714359004271 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 714359004272 active site 714359004273 Zn binding site [ion binding]; other site 714359004274 putative transposase OrfB; Reviewed; Region: PHA02517 714359004275 HTH-like domain; Region: HTH_21; pfam13276 714359004276 Integrase core domain; Region: rve; pfam00665 714359004277 Integrase core domain; Region: rve_2; pfam13333 714359004278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714359004279 Helix-turn-helix domain; Region: HTH_28; pfam13518 714359004280 Helix-turn-helix domain; Region: HTH_28; pfam13518 714359004281 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359004282 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359004283 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 714359004284 active site 714359004285 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714359004286 active site 714359004287 xanthine permease; Region: pbuX; TIGR03173 714359004288 Predicted membrane protein [Function unknown]; Region: COG2311 714359004289 Protein of unknown function (DUF418); Region: DUF418; cl12135 714359004290 Protein of unknown function (DUF418); Region: DUF418; pfam04235 714359004291 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 714359004292 Dynamin family; Region: Dynamin_N; pfam00350 714359004293 G1 box; other site 714359004294 GTP/Mg2+ binding site [chemical binding]; other site 714359004295 G2 box; other site 714359004296 Switch I region; other site 714359004297 G3 box; other site 714359004298 Switch II region; other site 714359004299 G4 box; other site 714359004300 G5 box; other site 714359004301 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 714359004302 Dynamin family; Region: Dynamin_N; pfam00350 714359004303 G1 box; other site 714359004304 GTP/Mg2+ binding site [chemical binding]; other site 714359004305 G2 box; other site 714359004306 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 714359004307 G3 box; other site 714359004308 Switch II region; other site 714359004309 GTP/Mg2+ binding site [chemical binding]; other site 714359004310 G4 box; other site 714359004311 G5 box; other site 714359004312 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 714359004313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004314 Coenzyme A binding pocket [chemical binding]; other site 714359004315 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 714359004316 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 714359004317 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 714359004318 active site residue [active] 714359004319 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 714359004320 active site residue [active] 714359004321 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 714359004322 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 714359004323 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 714359004324 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359004325 5'-3' exonuclease; Region: 53EXOc; smart00475 714359004326 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 714359004327 active site 714359004328 metal binding site 1 [ion binding]; metal-binding site 714359004329 putative 5' ssDNA interaction site; other site 714359004330 metal binding site 3; metal-binding site 714359004331 metal binding site 2 [ion binding]; metal-binding site 714359004332 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 714359004333 putative DNA binding site [nucleotide binding]; other site 714359004334 putative metal binding site [ion binding]; other site 714359004335 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 714359004336 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 714359004337 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 714359004338 Chain length determinant protein; Region: Wzz; cl15801 714359004339 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 714359004340 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 714359004341 Bacterial sugar transferase; Region: Bac_transf; pfam02397 714359004342 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 714359004343 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 714359004344 O-Antigen ligase; Region: Wzy_C; pfam04932 714359004345 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 714359004346 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 714359004347 active site 714359004348 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714359004349 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 714359004350 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 714359004351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 714359004353 Coenzyme A binding pocket [chemical binding]; other site 714359004354 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 714359004355 Isochorismatase family; Region: Isochorismatase; pfam00857 714359004356 catalytic triad [active] 714359004357 conserved cis-peptide bond; other site 714359004358 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714359004359 EamA-like transporter family; Region: EamA; pfam00892 714359004360 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 714359004361 RNA/DNA hybrid binding site [nucleotide binding]; other site 714359004362 active site 714359004363 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 714359004364 active site 714359004365 catalytic residues [active] 714359004366 QueT transporter; Region: QueT; pfam06177 714359004367 hypothetical protein; Validated; Region: PRK07708 714359004368 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 714359004369 RNA/DNA hybrid binding site [nucleotide binding]; other site 714359004370 active site 714359004371 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 714359004372 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714359004373 DNA-binding site [nucleotide binding]; DNA binding site 714359004374 RNA-binding motif; other site 714359004375 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 714359004376 LysE type translocator; Region: LysE; pfam01810 714359004377 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 714359004378 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 714359004379 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 714359004380 Na binding site [ion binding]; other site 714359004381 aminotransferase; Validated; Region: PRK07678 714359004382 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359004383 inhibitor-cofactor binding pocket; inhibition site 714359004384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359004385 catalytic residue [active] 714359004386 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 714359004387 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 714359004388 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 714359004389 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 714359004390 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359004391 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 714359004392 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 714359004393 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 714359004394 DNA binding residues [nucleotide binding] 714359004395 drug binding residues [chemical binding]; other site 714359004396 dimer interface [polypeptide binding]; other site 714359004397 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 714359004398 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 714359004399 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 714359004400 Predicted membrane protein [Function unknown]; Region: COG2323 714359004401 Uncharacterized conserved protein [Function unknown]; Region: COG1434 714359004402 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714359004403 putative active site [active] 714359004404 Tic20-like protein; Region: Tic20; pfam09685 714359004405 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 714359004406 dimer interface [polypeptide binding]; other site 714359004407 FMN binding site [chemical binding]; other site 714359004408 NADPH bind site [chemical binding]; other site 714359004409 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359004410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004411 putative substrate translocation pore; other site 714359004412 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 714359004413 bacterial Hfq-like; Region: Hfq; cd01716 714359004414 hexamer interface [polypeptide binding]; other site 714359004415 Sm1 motif; other site 714359004416 RNA binding site [nucleotide binding]; other site 714359004417 Sm2 motif; other site 714359004418 HD domain; Region: HD_3; pfam13023 714359004419 flagellar motor protein MotP; Reviewed; Region: PRK06743 714359004420 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 714359004421 flagellar motor protein MotS; Reviewed; Region: PRK06742 714359004422 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 714359004423 ligand binding site [chemical binding]; other site 714359004424 Response regulator receiver domain; Region: Response_reg; pfam00072 714359004425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359004426 active site 714359004427 phosphorylation site [posttranslational modification] 714359004428 intermolecular recognition site; other site 714359004429 dimerization interface [polypeptide binding]; other site 714359004430 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 714359004431 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 714359004432 putative binding surface; other site 714359004433 active site 714359004434 P2 response regulator binding domain; Region: P2; pfam07194 714359004435 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 714359004436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359004437 ATP binding site [chemical binding]; other site 714359004438 Mg2+ binding site [ion binding]; other site 714359004439 G-X-G motif; other site 714359004440 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 714359004441 flagellar motor switch protein; Reviewed; Region: PRK06782 714359004442 CheC-like family; Region: CheC; pfam04509 714359004443 CheC-like family; Region: CheC; pfam04509 714359004444 CheC-like family; Region: CheC; pfam04509 714359004445 CheC-like family; Region: CheC; pfam04509 714359004446 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 714359004447 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 714359004448 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714359004449 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 714359004450 active site 714359004451 DNA binding site [nucleotide binding] 714359004452 Int/Topo IB signature motif; other site 714359004453 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 714359004454 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 714359004455 Phage capsid family; Region: Phage_capsid; pfam05065 714359004456 Phage-related protein [Function unknown]; Region: COG4695; cl01923 714359004457 Phage portal protein; Region: Phage_portal; pfam04860 714359004458 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 714359004459 Phage terminase, small subunit; Region: Terminase_4; pfam05119 714359004460 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 714359004461 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 714359004462 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 714359004463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359004464 Protein of unknown function (DUF327); Region: DUF327; pfam03885 714359004465 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 714359004466 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 714359004467 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 714359004468 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 714359004469 flagellar capping protein; Validated; Region: fliD; PRK06798 714359004470 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 714359004471 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 714359004472 Flagellar protein FliS; Region: FliS; cl00654 714359004473 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 714359004474 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 714359004475 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 714359004476 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 714359004477 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 714359004478 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 714359004479 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 714359004480 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 714359004481 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 714359004482 FliG C-terminal domain; Region: FliG_C; pfam01706 714359004483 flagellar assembly protein H; Validated; Region: fliH; PRK06800 714359004484 Flagellar assembly protein FliH; Region: FliH; pfam02108 714359004485 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 714359004486 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 714359004487 Walker A motif; other site 714359004488 ATP binding site [chemical binding]; other site 714359004489 Walker B motif; other site 714359004490 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 714359004491 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 714359004492 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 714359004493 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 714359004494 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 714359004495 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 714359004496 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 714359004497 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 714359004498 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 714359004499 Response regulator receiver domain; Region: Response_reg; pfam00072 714359004500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359004501 active site 714359004502 phosphorylation site [posttranslational modification] 714359004503 intermolecular recognition site; other site 714359004504 dimerization interface [polypeptide binding]; other site 714359004505 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 714359004506 flagellin; Provisional; Region: PRK12807 714359004507 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 714359004508 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 714359004509 flagellin; Provisional; Region: PRK12807 714359004510 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 714359004511 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 714359004512 flagellin; Provisional; Region: PRK12807 714359004513 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 714359004514 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 714359004515 flagellin; Provisional; Region: PRK12807 714359004516 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 714359004517 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 714359004518 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 714359004519 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 714359004520 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714359004521 catalytic residue [active] 714359004522 flagellar motor switch protein; Validated; Region: PRK06789 714359004523 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 714359004524 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 714359004525 flagellar motor switch protein; Validated; Region: PRK06788 714359004526 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 714359004527 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 714359004528 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 714359004529 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 714359004530 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 714359004531 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 714359004532 FHIPEP family; Region: FHIPEP; pfam00771 714359004533 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 714359004534 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 714359004535 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 714359004536 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 714359004537 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 714359004538 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 714359004539 Predicted transcriptional regulators [Transcription]; Region: COG1378 714359004540 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 714359004541 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 714359004542 C-terminal domain interface [polypeptide binding]; other site 714359004543 sugar binding site [chemical binding]; other site 714359004544 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 714359004545 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 714359004546 Dienelactone hydrolase family; Region: DLH; pfam01738 714359004547 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 714359004548 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 714359004549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359004550 non-specific DNA binding site [nucleotide binding]; other site 714359004551 salt bridge; other site 714359004552 sequence-specific DNA binding site [nucleotide binding]; other site 714359004553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004554 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359004555 putative substrate translocation pore; other site 714359004556 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 714359004557 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 714359004558 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359004559 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359004560 dimerization interface [polypeptide binding]; other site 714359004561 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 714359004562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359004563 Q-loop/lid; other site 714359004564 ABC transporter signature motif; other site 714359004565 Walker B; other site 714359004566 D-loop; other site 714359004567 H-loop/switch region; other site 714359004568 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 714359004569 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 714359004570 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 714359004571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359004572 dimer interface [polypeptide binding]; other site 714359004573 conserved gate region; other site 714359004574 putative PBP binding loops; other site 714359004575 ABC-ATPase subunit interface; other site 714359004576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359004577 dimer interface [polypeptide binding]; other site 714359004578 conserved gate region; other site 714359004579 putative PBP binding loops; other site 714359004580 ABC-ATPase subunit interface; other site 714359004581 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 714359004582 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 714359004583 Beta-Casp domain; Region: Beta-Casp; smart01027 714359004584 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 714359004585 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 714359004586 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 714359004587 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359004588 catalytic core [active] 714359004589 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 714359004590 hypothetical protein; Provisional; Region: PRK09272 714359004591 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359004592 MarR family; Region: MarR_2; pfam12802 714359004593 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 714359004594 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 714359004595 active site 714359004596 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 714359004597 dimer interface [polypeptide binding]; other site 714359004598 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 714359004599 Ligand Binding Site [chemical binding]; other site 714359004600 Molecular Tunnel; other site 714359004601 RNA polymerase factor sigma-70; Validated; Region: PRK06811 714359004602 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359004603 DNA binding residues [nucleotide binding] 714359004604 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 714359004605 VPS10 domain; Region: VPS10; smart00602 714359004606 VPS10 domain; Region: VPS10; smart00602 714359004607 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 714359004608 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 714359004609 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 714359004610 Transcriptional regulators [Transcription]; Region: GntR; COG1802 714359004611 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359004612 DNA-binding site [nucleotide binding]; DNA binding site 714359004613 FCD domain; Region: FCD; pfam07729 714359004614 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714359004615 EamA-like transporter family; Region: EamA; pfam00892 714359004616 EamA-like transporter family; Region: EamA; pfam00892 714359004617 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 714359004618 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 714359004619 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 714359004620 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 714359004621 Predicted permeases [General function prediction only]; Region: COG0701 714359004622 TIGR03943 family protein; Region: TIGR03943 714359004623 Methyltransferase domain; Region: Methyltransf_24; pfam13578 714359004624 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 714359004625 short chain dehydrogenase; Provisional; Region: PRK06123 714359004626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359004627 NAD(P) binding site [chemical binding]; other site 714359004628 active site 714359004629 fumarate hydratase; Reviewed; Region: fumC; PRK00485 714359004630 Class II fumarases; Region: Fumarase_classII; cd01362 714359004631 active site 714359004632 tetramer interface [polypeptide binding]; other site 714359004633 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 714359004634 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 714359004635 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 714359004636 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 714359004637 active site pocket [active] 714359004638 oxyanion hole [active] 714359004639 catalytic triad [active] 714359004640 active site nucleophile [active] 714359004641 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 714359004642 Penicillinase repressor; Region: Pencillinase_R; pfam03965 714359004643 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 714359004644 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 714359004645 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 714359004646 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 714359004647 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 714359004648 catalytic residues [active] 714359004649 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 714359004650 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359004651 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 714359004652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359004653 non-specific DNA binding site [nucleotide binding]; other site 714359004654 salt bridge; other site 714359004655 sequence-specific DNA binding site [nucleotide binding]; other site 714359004656 Cupin domain; Region: Cupin_2; pfam07883 714359004657 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 714359004658 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 714359004659 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359004660 catalytic residue [active] 714359004661 Protein of unknown function (DUF445); Region: DUF445; pfam04286 714359004662 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 714359004663 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359004664 DNA binding residues [nucleotide binding] 714359004665 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359004666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359004667 active site 714359004668 phosphorylation site [posttranslational modification] 714359004669 intermolecular recognition site; other site 714359004670 dimerization interface [polypeptide binding]; other site 714359004671 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359004672 DNA binding residues [nucleotide binding] 714359004673 dimerization interface [polypeptide binding]; other site 714359004674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 714359004675 Histidine kinase; Region: HisKA_3; pfam07730 714359004676 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359004677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359004678 Walker A/P-loop; other site 714359004679 ATP binding site [chemical binding]; other site 714359004680 Q-loop/lid; other site 714359004681 ABC transporter signature motif; other site 714359004682 Walker B; other site 714359004683 D-loop; other site 714359004684 H-loop/switch region; other site 714359004685 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 714359004686 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 714359004687 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 714359004688 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 714359004689 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 714359004690 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 714359004691 PLD-like domain; Region: PLDc_2; pfam13091 714359004692 putative active site [active] 714359004693 catalytic site [active] 714359004694 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 714359004695 PLD-like domain; Region: PLDc_2; pfam13091 714359004696 putative active site [active] 714359004697 catalytic site [active] 714359004698 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 714359004699 putative nucleotide binding site [chemical binding]; other site 714359004700 uridine monophosphate binding site [chemical binding]; other site 714359004701 homohexameric interface [polypeptide binding]; other site 714359004702 Probable transposase; Region: OrfB_IS605; pfam01385 714359004703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714359004704 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714359004705 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 714359004706 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 714359004707 aspartate ammonia-lyase; Provisional; Region: PRK14515 714359004708 Aspartase; Region: Aspartase; cd01357 714359004709 active sites [active] 714359004710 tetramer interface [polypeptide binding]; other site 714359004711 malate dehydrogenase; Provisional; Region: PRK13529 714359004712 Malic enzyme, N-terminal domain; Region: malic; pfam00390 714359004713 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 714359004714 NAD(P) binding site [chemical binding]; other site 714359004715 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359004716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359004717 ATP binding site [chemical binding]; other site 714359004718 Mg2+ binding site [ion binding]; other site 714359004719 G-X-G motif; other site 714359004720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359004721 Response regulator receiver domain; Region: Response_reg; pfam00072 714359004722 active site 714359004723 phosphorylation site [posttranslational modification] 714359004724 intermolecular recognition site; other site 714359004725 dimerization interface [polypeptide binding]; other site 714359004726 YcbB domain; Region: YcbB; pfam08664 714359004727 SWIM zinc finger; Region: SWIM; pfam04434 714359004728 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 714359004729 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 714359004730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359004731 ATP binding site [chemical binding]; other site 714359004732 putative Mg++ binding site [ion binding]; other site 714359004733 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359004734 nucleotide binding region [chemical binding]; other site 714359004735 ATP-binding site [chemical binding]; other site 714359004736 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 714359004737 dimer interface [polypeptide binding]; other site 714359004738 active site 714359004739 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359004740 aspartate kinase; Reviewed; Region: PRK06635 714359004741 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 714359004742 putative nucleotide binding site [chemical binding]; other site 714359004743 putative catalytic residues [active] 714359004744 putative Mg ion binding site [ion binding]; other site 714359004745 putative aspartate binding site [chemical binding]; other site 714359004746 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 714359004747 putative allosteric regulatory site; other site 714359004748 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 714359004749 putative allosteric regulatory residue; other site 714359004750 DoxX-like family; Region: DoxX_3; pfam13781 714359004751 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 714359004752 YndJ-like protein; Region: YndJ; pfam14158 714359004753 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 714359004754 putative active site [active] 714359004755 nucleotide binding site [chemical binding]; other site 714359004756 nudix motif; other site 714359004757 putative metal binding site [ion binding]; other site 714359004758 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359004759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004760 putative substrate translocation pore; other site 714359004761 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 714359004762 Predicted transcriptional regulators [Transcription]; Region: COG1695 714359004763 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 714359004764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004765 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359004766 putative substrate translocation pore; other site 714359004767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004768 putative substrate translocation pore; other site 714359004769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004770 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359004771 putative substrate translocation pore; other site 714359004772 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 714359004773 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 714359004774 dimer interface [polypeptide binding]; other site 714359004775 active site 714359004776 CoA binding pocket [chemical binding]; other site 714359004777 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 714359004778 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 714359004779 HflX GTPase family; Region: HflX; cd01878 714359004780 G1 box; other site 714359004781 GTP/Mg2+ binding site [chemical binding]; other site 714359004782 Switch I region; other site 714359004783 G2 box; other site 714359004784 G3 box; other site 714359004785 Switch II region; other site 714359004786 G4 box; other site 714359004787 G5 box; other site 714359004788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004789 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359004790 putative substrate translocation pore; other site 714359004791 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 714359004792 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 714359004793 dimer interface [polypeptide binding]; other site 714359004794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359004795 catalytic residue [active] 714359004796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 714359004797 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 714359004798 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 714359004799 Na2 binding site [ion binding]; other site 714359004800 putative substrate binding site 1 [chemical binding]; other site 714359004801 Na binding site 1 [ion binding]; other site 714359004802 putative substrate binding site 2 [chemical binding]; other site 714359004803 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 714359004804 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 714359004805 NodB motif; other site 714359004806 putative active site [active] 714359004807 putative catalytic site [active] 714359004808 putative Zn binding site [ion binding]; other site 714359004809 Mor transcription activator family; Region: Mor; cl02360 714359004810 Predicted membrane protein [Function unknown]; Region: COG2323 714359004811 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 714359004812 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 714359004813 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 714359004814 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 714359004815 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 714359004816 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 714359004817 methionine sulfoxide reductase A; Provisional; Region: PRK14054 714359004818 short chain dehydrogenase; Provisional; Region: PRK12747 714359004819 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 714359004820 NADP binding site [chemical binding]; other site 714359004821 homodimer interface [polypeptide binding]; other site 714359004822 active site 714359004823 substrate binding site [chemical binding]; other site 714359004824 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 714359004825 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 714359004826 homodimer interface [polypeptide binding]; other site 714359004827 substrate-cofactor binding pocket; other site 714359004828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359004829 catalytic residue [active] 714359004830 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 714359004831 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 714359004832 PYR/PP interface [polypeptide binding]; other site 714359004833 dimer interface [polypeptide binding]; other site 714359004834 TPP binding site [chemical binding]; other site 714359004835 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 714359004836 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 714359004837 TPP-binding site [chemical binding]; other site 714359004838 dimer interface [polypeptide binding]; other site 714359004839 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 714359004840 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 714359004841 putative valine binding site [chemical binding]; other site 714359004842 dimer interface [polypeptide binding]; other site 714359004843 ketol-acid reductoisomerase; Provisional; Region: PRK05479 714359004844 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 714359004845 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 714359004846 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 714359004847 threonine dehydratase; Validated; Region: PRK08639 714359004848 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 714359004849 tetramer interface [polypeptide binding]; other site 714359004850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359004851 catalytic residue [active] 714359004852 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 714359004853 putative Ile/Val binding site [chemical binding]; other site 714359004854 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 714359004855 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 714359004856 putative active site [active] 714359004857 putative metal binding site [ion binding]; other site 714359004858 Protein of unknown function (DUF554); Region: DUF554; pfam04474 714359004859 drug efflux system protein MdtG; Provisional; Region: PRK09874 714359004860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004861 putative substrate translocation pore; other site 714359004862 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 714359004863 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 714359004864 putative active site [active] 714359004865 metal binding site [ion binding]; metal-binding site 714359004866 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 714359004867 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 714359004868 LytTr DNA-binding domain; Region: LytTR; pfam04397 714359004869 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 714359004870 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 714359004871 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 714359004872 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 714359004873 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 714359004874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004875 Coenzyme A binding pocket [chemical binding]; other site 714359004876 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 714359004877 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 714359004878 active site 714359004879 putative substrate binding pocket [chemical binding]; other site 714359004880 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359004881 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359004882 peptide binding site [polypeptide binding]; other site 714359004883 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 714359004884 hypothetical protein; Provisional; Region: PRK06922 714359004885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359004886 S-adenosylmethionine binding site [chemical binding]; other site 714359004887 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359004888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004889 Coenzyme A binding pocket [chemical binding]; other site 714359004890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 714359004891 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359004892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359004893 active site 714359004894 phosphorylation site [posttranslational modification] 714359004895 intermolecular recognition site; other site 714359004896 dimerization interface [polypeptide binding]; other site 714359004897 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359004898 DNA binding site [nucleotide binding] 714359004899 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359004900 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 714359004901 manganese transport protein MntH; Reviewed; Region: PRK00701 714359004902 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 714359004903 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 714359004904 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 714359004905 active site residue [active] 714359004906 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 714359004907 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 714359004908 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 714359004909 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 714359004910 Amino acid permease; Region: AA_permease_2; pfam13520 714359004911 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359004912 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359004913 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359004914 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 714359004915 hypothetical protein; Provisional; Region: PRK12856 714359004916 CAAX protease self-immunity; Region: Abi; cl00558 714359004917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359004918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359004919 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 714359004920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359004921 DNA binding residues [nucleotide binding] 714359004922 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 714359004923 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 714359004924 intersubunit interface [polypeptide binding]; other site 714359004925 active site 714359004926 catalytic residue [active] 714359004927 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359004928 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 714359004929 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 714359004930 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 714359004931 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 714359004932 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 714359004933 active site 714359004934 catalytic motif [active] 714359004935 Zn binding site [ion binding]; other site 714359004936 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 714359004937 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 714359004938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714359004939 Helix-turn-helix domain; Region: HTH_28; pfam13518 714359004940 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 714359004941 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 714359004942 hypothetical protein; Provisional; Region: PRK01631 714359004943 proline aminopeptidase P II; Provisional; Region: PRK10879 714359004944 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 714359004945 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 714359004946 active site 714359004947 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 714359004948 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 714359004949 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 714359004950 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 714359004951 Multicopper oxidase; Region: Cu-oxidase; pfam00394 714359004952 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 714359004953 DNA topoisomerase III; Provisional; Region: PRK07726 714359004954 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 714359004955 active site 714359004956 putative interdomain interaction site [polypeptide binding]; other site 714359004957 putative metal-binding site [ion binding]; other site 714359004958 putative nucleotide binding site [chemical binding]; other site 714359004959 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 714359004960 domain I; other site 714359004961 DNA binding groove [nucleotide binding] 714359004962 phosphate binding site [ion binding]; other site 714359004963 domain II; other site 714359004964 domain III; other site 714359004965 nucleotide binding site [chemical binding]; other site 714359004966 catalytic site [active] 714359004967 domain IV; other site 714359004968 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 714359004969 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 714359004970 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 714359004971 Sodium Bile acid symporter family; Region: SBF; cl17470 714359004972 azoreductase; Provisional; Region: PRK13555 714359004973 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 714359004974 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359004975 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 714359004976 dimer interface [polypeptide binding]; other site 714359004977 substrate binding site [chemical binding]; other site 714359004978 metal binding site [ion binding]; metal-binding site 714359004979 CopC domain; Region: CopC; pfam04234 714359004980 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 714359004981 YtkA-like; Region: YtkA; pfam13115 714359004982 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 714359004983 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714359004984 EamA-like transporter family; Region: EamA; pfam00892 714359004985 EamA-like transporter family; Region: EamA; pfam00892 714359004986 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359004987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359004988 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359004989 dimerization interface [polypeptide binding]; other site 714359004990 Predicted transcriptional regulator [Transcription]; Region: COG1959 714359004991 Transcriptional regulator; Region: Rrf2; pfam02082 714359004992 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 714359004993 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 714359004994 catalytic residues [active] 714359004995 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 714359004996 dimer interface [polypeptide binding]; other site 714359004997 FMN binding site [chemical binding]; other site 714359004998 amidase; Provisional; Region: PRK06828 714359004999 Amidase; Region: Amidase; cl11426 714359005000 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 714359005001 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 714359005002 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 714359005003 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359005004 NAD binding site [chemical binding]; other site 714359005005 dimer interface [polypeptide binding]; other site 714359005006 substrate binding site [chemical binding]; other site 714359005007 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 714359005008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 714359005009 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 714359005010 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 714359005011 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 714359005012 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 714359005013 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 714359005014 putative ligand binding site [chemical binding]; other site 714359005015 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 714359005016 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 714359005017 Walker A/P-loop; other site 714359005018 ATP binding site [chemical binding]; other site 714359005019 Q-loop/lid; other site 714359005020 ABC transporter signature motif; other site 714359005021 Walker B; other site 714359005022 D-loop; other site 714359005023 H-loop/switch region; other site 714359005024 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 714359005025 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 714359005026 Walker A/P-loop; other site 714359005027 ATP binding site [chemical binding]; other site 714359005028 Q-loop/lid; other site 714359005029 ABC transporter signature motif; other site 714359005030 Walker B; other site 714359005031 D-loop; other site 714359005032 H-loop/switch region; other site 714359005033 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714359005034 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 714359005035 TM-ABC transporter signature motif; other site 714359005036 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 714359005037 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 714359005038 TM-ABC transporter signature motif; other site 714359005039 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359005040 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359005041 LysR substrate binding domain; Region: LysR_substrate; pfam03466 714359005042 dimerization interface [polypeptide binding]; other site 714359005043 lipoprotein; Provisional; Region: PRK10540 714359005044 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 714359005045 MarR family; Region: MarR_2; cl17246 714359005046 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 714359005047 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 714359005048 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 714359005049 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 714359005050 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 714359005051 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 714359005052 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 714359005053 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359005054 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 714359005055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359005056 Walker A/P-loop; other site 714359005057 ATP binding site [chemical binding]; other site 714359005058 Q-loop/lid; other site 714359005059 ABC transporter signature motif; other site 714359005060 Walker B; other site 714359005061 D-loop; other site 714359005062 H-loop/switch region; other site 714359005063 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 714359005064 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359005065 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 714359005066 Walker A/P-loop; other site 714359005067 ATP binding site [chemical binding]; other site 714359005068 Q-loop/lid; other site 714359005069 ABC transporter signature motif; other site 714359005070 Walker B; other site 714359005071 D-loop; other site 714359005072 H-loop/switch region; other site 714359005073 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 714359005074 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 714359005075 active site 714359005076 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 714359005077 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359005078 active site 714359005079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359005080 Methyltransferase domain; Region: Methyltransf_23; pfam13489 714359005081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 714359005082 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 714359005083 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 714359005084 inhibitor-cofactor binding pocket; inhibition site 714359005085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359005086 catalytic residue [active] 714359005087 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 714359005088 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 714359005089 trimer interface [polypeptide binding]; other site 714359005090 active site 714359005091 substrate binding site [chemical binding]; other site 714359005092 CoA binding site [chemical binding]; other site 714359005093 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 714359005094 putative dimer interface [polypeptide binding]; other site 714359005095 catalytic triad [active] 714359005096 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714359005097 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 714359005098 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 714359005099 dimer interface [polypeptide binding]; other site 714359005100 FMN binding site [chemical binding]; other site 714359005101 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359005102 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359005103 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359005104 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 714359005105 NlpC/P60 family; Region: NLPC_P60; pfam00877 714359005106 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359005107 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714359005108 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359005109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359005110 Walker A/P-loop; other site 714359005111 ATP binding site [chemical binding]; other site 714359005112 Q-loop/lid; other site 714359005113 ABC transporter signature motif; other site 714359005114 Walker B; other site 714359005115 D-loop; other site 714359005116 H-loop/switch region; other site 714359005117 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359005118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359005119 active site 714359005120 phosphorylation site [posttranslational modification] 714359005121 intermolecular recognition site; other site 714359005122 dimerization interface [polypeptide binding]; other site 714359005123 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359005124 DNA binding site [nucleotide binding] 714359005125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359005126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359005127 dimerization interface [polypeptide binding]; other site 714359005128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359005129 dimer interface [polypeptide binding]; other site 714359005130 phosphorylation site [posttranslational modification] 714359005131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359005132 ATP binding site [chemical binding]; other site 714359005133 Mg2+ binding site [ion binding]; other site 714359005134 G-X-G motif; other site 714359005135 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 714359005136 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 714359005137 classical (c) SDRs; Region: SDR_c; cd05233 714359005138 NAD(P) binding site [chemical binding]; other site 714359005139 active site 714359005140 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 714359005141 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 714359005142 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 714359005143 NodB motif; other site 714359005144 active site 714359005145 catalytic site [active] 714359005146 metal binding site [ion binding]; metal-binding site 714359005147 SdpI/YhfL protein family; Region: SdpI; pfam13630 714359005148 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 714359005149 nudix motif; other site 714359005150 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 714359005151 homoserine dehydrogenase; Provisional; Region: PRK06349 714359005152 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 714359005153 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 714359005154 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 714359005155 threonine synthase; Reviewed; Region: PRK06721 714359005156 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 714359005157 homodimer interface [polypeptide binding]; other site 714359005158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359005159 catalytic residue [active] 714359005160 homoserine kinase; Provisional; Region: PRK01212 714359005161 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 714359005162 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 714359005163 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 714359005164 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 714359005165 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359005166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359005167 active site 714359005168 phosphorylation site [posttranslational modification] 714359005169 intermolecular recognition site; other site 714359005170 dimerization interface [polypeptide binding]; other site 714359005171 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359005172 DNA binding site [nucleotide binding] 714359005173 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 714359005174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359005175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359005176 dimer interface [polypeptide binding]; other site 714359005177 phosphorylation site [posttranslational modification] 714359005178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359005179 ATP binding site [chemical binding]; other site 714359005180 Mg2+ binding site [ion binding]; other site 714359005181 G-X-G motif; other site 714359005182 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 714359005183 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 714359005184 NodB motif; other site 714359005185 active site 714359005186 catalytic site [active] 714359005187 Zn binding site [ion binding]; other site 714359005188 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 714359005189 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 714359005190 MgtC family; Region: MgtC; pfam02308 714359005191 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 714359005192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005193 Coenzyme A binding pocket [chemical binding]; other site 714359005194 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 714359005195 IucA / IucC family; Region: IucA_IucC; pfam04183 714359005196 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 714359005197 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 714359005198 IucA / IucC family; Region: IucA_IucC; pfam04183 714359005199 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 714359005200 acyl-CoA synthetase; Validated; Region: PRK08308 714359005201 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 714359005202 acyl-activating enzyme (AAE) consensus motif; other site 714359005203 AMP binding site [chemical binding]; other site 714359005204 active site 714359005205 CoA binding site [chemical binding]; other site 714359005206 acyl carrier protein; Provisional; Region: PRK07639 714359005207 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 714359005208 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 714359005209 Metal-binding active site; metal-binding site 714359005210 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359005211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359005212 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359005213 putative substrate translocation pore; other site 714359005214 Lysine efflux permease [General function prediction only]; Region: COG1279 714359005215 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359005216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359005217 DNA-binding site [nucleotide binding]; DNA binding site 714359005218 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359005219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359005220 homodimer interface [polypeptide binding]; other site 714359005221 catalytic residue [active] 714359005222 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 714359005223 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 714359005224 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 714359005225 active site 714359005226 nucleophile elbow; other site 714359005227 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 714359005228 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 714359005229 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 714359005230 nudix motif; other site 714359005231 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 714359005232 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 714359005233 homodimer interface [polypeptide binding]; other site 714359005234 NAD binding pocket [chemical binding]; other site 714359005235 ATP binding pocket [chemical binding]; other site 714359005236 Mg binding site [ion binding]; other site 714359005237 active-site loop [active] 714359005238 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 714359005239 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 714359005240 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 714359005241 active site 714359005242 catalytic residues [active] 714359005243 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359005244 dimerization interface [polypeptide binding]; other site 714359005245 putative DNA binding site [nucleotide binding]; other site 714359005246 putative Zn2+ binding site [ion binding]; other site 714359005247 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359005248 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714359005249 active site 714359005250 catalytic tetrad [active] 714359005251 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 714359005252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359005253 putative substrate translocation pore; other site 714359005254 Protein of unknown function (DUF805); Region: DUF805; pfam05656 714359005255 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 714359005256 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 714359005257 GTP/Mg2+ binding site [chemical binding]; other site 714359005258 G4 box; other site 714359005259 G5 box; other site 714359005260 G1 box; other site 714359005261 Switch I region; other site 714359005262 G2 box; other site 714359005263 G3 box; other site 714359005264 Switch II region; other site 714359005265 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 714359005266 Cache domain; Region: Cache_1; pfam02743 714359005267 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359005268 dimerization interface [polypeptide binding]; other site 714359005269 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359005270 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359005271 dimer interface [polypeptide binding]; other site 714359005272 putative CheW interface [polypeptide binding]; other site 714359005273 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 714359005274 Uncharacterized membrane protein [Function unknown]; Region: COG3949 714359005275 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 714359005276 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 714359005277 dimerization interface [polypeptide binding]; other site 714359005278 DPS ferroxidase diiron center [ion binding]; other site 714359005279 ion pore; other site 714359005280 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 714359005281 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359005282 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 714359005283 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 714359005284 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 714359005285 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 714359005286 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359005287 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359005288 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359005289 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714359005290 active site 714359005291 catalytic tetrad [active] 714359005292 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 714359005293 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 714359005294 P-loop, Walker A motif; other site 714359005295 Base recognition motif; other site 714359005296 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 714359005297 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 714359005298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005299 Coenzyme A binding pocket [chemical binding]; other site 714359005300 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 714359005301 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 714359005302 metal binding site [ion binding]; metal-binding site 714359005303 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 714359005304 NADH(P)-binding; Region: NAD_binding_10; pfam13460 714359005305 NAD binding site [chemical binding]; other site 714359005306 active site 714359005307 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 714359005308 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 714359005309 active site 714359005310 FMN binding site [chemical binding]; other site 714359005311 substrate binding site [chemical binding]; other site 714359005312 homotetramer interface [polypeptide binding]; other site 714359005313 catalytic residue [active] 714359005314 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 714359005315 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 714359005316 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 714359005317 DNA binding site [nucleotide binding] 714359005318 active site 714359005319 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 714359005320 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359005321 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359005322 peptide binding site [polypeptide binding]; other site 714359005323 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 714359005324 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359005325 active site 714359005326 metal binding site [ion binding]; metal-binding site 714359005327 short chain dehydrogenase; Provisional; Region: PRK08309 714359005328 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359005329 catalytic core [active] 714359005330 CotH protein; Region: CotH; pfam08757 714359005331 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 714359005332 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 714359005333 nudix motif; other site 714359005334 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714359005335 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 714359005336 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 714359005337 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 714359005338 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 714359005339 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 714359005340 Cl binding site [ion binding]; other site 714359005341 oligomer interface [polypeptide binding]; other site 714359005342 Predicted permeases [General function prediction only]; Region: COG0701 714359005343 Predicted membrane protein [Function unknown]; Region: COG3689 714359005344 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 714359005345 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 714359005346 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 714359005347 putative active site [active] 714359005348 catalytic site [active] 714359005349 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 714359005350 putative active site [active] 714359005351 catalytic site [active] 714359005352 Coat F domain; Region: Coat_F; pfam07875 714359005353 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 714359005354 NADH(P)-binding; Region: NAD_binding_10; pfam13460 714359005355 NAD binding site [chemical binding]; other site 714359005356 substrate binding site [chemical binding]; other site 714359005357 putative active site [active] 714359005358 Protein of unknown function (DUF456); Region: DUF456; pfam04306 714359005359 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 714359005360 Domain of unknown function DUF21; Region: DUF21; pfam01595 714359005361 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714359005362 Transporter associated domain; Region: CorC_HlyC; smart01091 714359005363 FOG: CBS domain [General function prediction only]; Region: COG0517 714359005364 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 714359005365 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 714359005366 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 714359005367 dimer interface [polypeptide binding]; other site 714359005368 putative tRNA-binding site [nucleotide binding]; other site 714359005369 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 714359005370 DinB superfamily; Region: DinB_2; pfam12867 714359005371 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 714359005372 stage II sporulation protein P; Region: spore_II_P; TIGR02867 714359005373 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359005374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005375 Coenzyme A binding pocket [chemical binding]; other site 714359005376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 714359005377 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 714359005378 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 714359005379 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 714359005380 nudix motif; other site 714359005381 amidase; Provisional; Region: PRK06828 714359005382 Amidase; Region: Amidase; pfam01425 714359005383 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359005384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359005385 putative substrate translocation pore; other site 714359005386 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 714359005387 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 714359005388 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 714359005389 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 714359005390 stage II sporulation protein P; Region: spore_II_P; TIGR02867 714359005391 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359005392 catalytic core [active] 714359005393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359005394 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359005395 active site 714359005396 motif I; other site 714359005397 motif II; other site 714359005398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359005399 multidrug resistance protein MdtH; Provisional; Region: PRK11646 714359005400 DinB superfamily; Region: DinB_2; pfam12867 714359005401 DinB family; Region: DinB; cl17821 714359005402 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 714359005403 alanine racemase; Reviewed; Region: alr; PRK00053 714359005404 active site 714359005405 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714359005406 dimer interface [polypeptide binding]; other site 714359005407 substrate binding site [chemical binding]; other site 714359005408 catalytic residues [active] 714359005409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005410 Coenzyme A binding pocket [chemical binding]; other site 714359005411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005412 Coenzyme A binding pocket [chemical binding]; other site 714359005413 active site 714359005414 ATP binding site [chemical binding]; other site 714359005415 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 714359005416 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 714359005417 glycosyltransferase, MGT family; Region: MGT; TIGR01426 714359005418 active site 714359005419 TDP-binding site; other site 714359005420 acceptor substrate-binding pocket; other site 714359005421 homodimer interface [polypeptide binding]; other site 714359005422 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359005423 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359005424 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 714359005425 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359005426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359005427 DNA-binding site [nucleotide binding]; DNA binding site 714359005428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359005429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359005430 homodimer interface [polypeptide binding]; other site 714359005431 catalytic residue [active] 714359005432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005433 Coenzyme A binding pocket [chemical binding]; other site 714359005434 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359005435 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 714359005436 active site 714359005437 metal binding site [ion binding]; metal-binding site 714359005438 Src Homology 3 domain superfamily; Region: SH3; cl17036 714359005439 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 714359005440 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359005441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005442 Coenzyme A binding pocket [chemical binding]; other site 714359005443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 714359005444 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 714359005445 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 714359005446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005447 Coenzyme A binding pocket [chemical binding]; other site 714359005448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005449 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359005450 Coenzyme A binding pocket [chemical binding]; other site 714359005451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 714359005452 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 714359005453 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 714359005454 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 714359005455 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 714359005456 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 714359005457 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 714359005458 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 714359005459 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 714359005460 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 714359005461 LXG domain of WXG superfamily; Region: LXG; pfam04740 714359005462 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 714359005463 Predicted acetyltransferase [General function prediction only]; Region: COG3393 714359005464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005465 Coenzyme A binding pocket [chemical binding]; other site 714359005466 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 714359005467 Methyltransferase domain; Region: Methyltransf_23; pfam13489 714359005468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359005469 S-adenosylmethionine binding site [chemical binding]; other site 714359005470 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 714359005471 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 714359005472 Potassium binding sites [ion binding]; other site 714359005473 Cesium cation binding sites [ion binding]; other site 714359005474 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 714359005475 DEAD-like helicases superfamily; Region: DEXDc; smart00487 714359005476 ATP binding site [chemical binding]; other site 714359005477 putative Mg++ binding site [ion binding]; other site 714359005478 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359005479 nucleotide binding region [chemical binding]; other site 714359005480 ATP-binding site [chemical binding]; other site 714359005481 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 714359005482 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359005483 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 714359005484 RNA polymerase sigma factor; Provisional; Region: PRK12543 714359005485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359005486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359005487 DNA binding residues [nucleotide binding] 714359005488 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 714359005489 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 714359005490 ABC1 family; Region: ABC1; cl17513 714359005491 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 714359005492 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359005493 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 714359005494 catalytic residues [active] 714359005495 dimer interface [polypeptide binding]; other site 714359005496 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 714359005497 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 714359005498 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 714359005499 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 714359005500 Protein of unknown function DUF58; Region: DUF58; pfam01882 714359005501 MoxR-like ATPases [General function prediction only]; Region: COG0714 714359005502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359005503 Walker A motif; other site 714359005504 ATP binding site [chemical binding]; other site 714359005505 Walker B motif; other site 714359005506 arginine finger; other site 714359005507 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 714359005508 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 714359005509 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714359005510 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714359005511 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714359005512 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 714359005513 molybdopterin cofactor binding site; other site 714359005514 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 714359005515 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 714359005516 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 714359005517 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 714359005518 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714359005519 ligand binding site [chemical binding]; other site 714359005520 flexible hinge region; other site 714359005521 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 714359005522 putative switch regulator; other site 714359005523 non-specific DNA interactions [nucleotide binding]; other site 714359005524 DNA binding site [nucleotide binding] 714359005525 sequence specific DNA binding site [nucleotide binding]; other site 714359005526 putative cAMP binding site [chemical binding]; other site 714359005527 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 714359005528 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359005529 FeS/SAM binding site; other site 714359005530 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 714359005531 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 714359005532 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 714359005533 ATP binding site [chemical binding]; other site 714359005534 substrate interface [chemical binding]; other site 714359005535 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 714359005536 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 714359005537 dimer interface [polypeptide binding]; other site 714359005538 putative functional site; other site 714359005539 putative MPT binding site; other site 714359005540 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 714359005541 MoaE homodimer interface [polypeptide binding]; other site 714359005542 MoaD interaction [polypeptide binding]; other site 714359005543 active site residues [active] 714359005544 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 714359005545 MoaE interaction surface [polypeptide binding]; other site 714359005546 MoeB interaction surface [polypeptide binding]; other site 714359005547 thiocarboxylated glycine; other site 714359005548 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 714359005549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359005550 putative substrate translocation pore; other site 714359005551 Predicted permeases [General function prediction only]; Region: COG0679 714359005552 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 714359005553 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 714359005554 putative active site [active] 714359005555 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 714359005556 putative active site [active] 714359005557 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 714359005558 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 714359005559 active site 714359005560 SAM binding site [chemical binding]; other site 714359005561 homodimer interface [polypeptide binding]; other site 714359005562 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 714359005563 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 714359005564 [2Fe-2S] cluster binding site [ion binding]; other site 714359005565 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 714359005566 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714359005567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714359005568 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 714359005569 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 714359005570 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 714359005571 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 714359005572 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 714359005573 Hemerythrin-like domain; Region: Hr-like; cd12108 714359005574 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 714359005575 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 714359005576 PGAP1-like protein; Region: PGAP1; pfam07819 714359005577 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 714359005578 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 714359005579 metal binding site [ion binding]; metal-binding site 714359005580 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359005581 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 714359005582 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359005583 Zn2+ binding site [ion binding]; other site 714359005584 Mg2+ binding site [ion binding]; other site 714359005585 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359005586 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359005587 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359005588 ABC transporter; Region: ABC_tran_2; pfam12848 714359005589 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359005590 Bax inhibitor 1 like; Region: BaxI_1; cl17691 714359005591 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 714359005592 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 714359005593 Virulence factor; Region: Virulence_fact; pfam13769 714359005594 HEAT repeats; Region: HEAT_2; pfam13646 714359005595 HEAT repeats; Region: HEAT_2; pfam13646 714359005596 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 714359005597 Protein of unknown function, DUF393; Region: DUF393; pfam04134 714359005598 Disulphide isomerase; Region: Disulph_isomer; pfam06491 714359005599 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 714359005600 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 714359005601 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 714359005602 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 714359005603 active site 714359005604 HIGH motif; other site 714359005605 KMSK motif region; other site 714359005606 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 714359005607 tRNA binding surface [nucleotide binding]; other site 714359005608 anticodon binding site; other site 714359005609 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 714359005610 putative catalytic site [active] 714359005611 putative phosphate binding site [ion binding]; other site 714359005612 putative metal binding site [ion binding]; other site 714359005613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359005614 binding surface 714359005615 TPR motif; other site 714359005616 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 714359005617 putative active site [active] 714359005618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359005619 binding surface 714359005620 TPR motif; other site 714359005621 TPR repeat; Region: TPR_11; pfam13414 714359005622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359005623 binding surface 714359005624 TPR motif; other site 714359005625 Tetratricopeptide repeat; Region: TPR_16; pfam13432 714359005626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359005627 binding surface 714359005628 TPR motif; other site 714359005629 TPR repeat; Region: TPR_11; pfam13414 714359005630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359005631 binding surface 714359005632 TPR motif; other site 714359005633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359005634 binding surface 714359005635 TPR motif; other site 714359005636 Tetratricopeptide repeat; Region: TPR_16; pfam13432 714359005637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359005638 binding surface 714359005639 TPR motif; other site 714359005640 Tetratricopeptide repeat; Region: TPR_9; pfam13371 714359005641 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 714359005642 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 714359005643 HIGH motif; other site 714359005644 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 714359005645 active site 714359005646 KMSKS motif; other site 714359005647 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 714359005648 tRNA binding surface [nucleotide binding]; other site 714359005649 anticodon binding site; other site 714359005650 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359005651 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359005652 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 714359005653 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 714359005654 Zn binding site [ion binding]; other site 714359005655 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 714359005656 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 714359005657 Dimer interface [polypeptide binding]; other site 714359005658 anticodon binding site; other site 714359005659 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 714359005660 homodimer interface [polypeptide binding]; other site 714359005661 motif 1; other site 714359005662 motif 2; other site 714359005663 active site 714359005664 motif 3; other site 714359005665 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 714359005666 Na2 binding site [ion binding]; other site 714359005667 putative substrate binding site 1 [chemical binding]; other site 714359005668 Na binding site 1 [ion binding]; other site 714359005669 putative substrate binding site 2 [chemical binding]; other site 714359005670 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 714359005671 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 714359005672 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 714359005673 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359005674 Eukaryotic phosphomannomutase; Region: PMM; cl17107 714359005675 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 714359005676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359005677 motif II; other site 714359005678 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 714359005679 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 714359005680 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 714359005681 putative active site [active] 714359005682 metal binding site [ion binding]; metal-binding site 714359005683 aspartate racemase; Region: asp_race; TIGR00035 714359005684 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 714359005685 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 714359005686 homodimer interaction site [polypeptide binding]; other site 714359005687 cofactor binding site; other site 714359005688 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 714359005689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005690 Coenzyme A binding pocket [chemical binding]; other site 714359005691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359005692 salt bridge; other site 714359005693 non-specific DNA binding site [nucleotide binding]; other site 714359005694 sequence-specific DNA binding site [nucleotide binding]; other site 714359005695 hypothetical protein; Validated; Region: PRK06769 714359005696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359005697 active site 714359005698 motif I; other site 714359005699 motif II; other site 714359005700 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359005701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005702 Coenzyme A binding pocket [chemical binding]; other site 714359005703 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714359005704 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714359005705 Walker A/P-loop; other site 714359005706 ATP binding site [chemical binding]; other site 714359005707 Q-loop/lid; other site 714359005708 ABC transporter signature motif; other site 714359005709 Walker B; other site 714359005710 D-loop; other site 714359005711 H-loop/switch region; other site 714359005712 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 714359005713 YpjP-like protein; Region: YpjP; pfam14005 714359005714 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359005715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359005716 motif II; other site 714359005717 hypothetical protein; Provisional; Region: PRK06724 714359005718 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359005719 active site 714359005720 metal binding site [ion binding]; metal-binding site 714359005721 Phosphotransferase enzyme family; Region: APH; pfam01636 714359005722 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 714359005723 active site 714359005724 substrate binding site [chemical binding]; other site 714359005725 ATP binding site [chemical binding]; other site 714359005726 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359005727 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359005728 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 714359005729 thymidylate synthase; Region: thym_sym; TIGR03284 714359005730 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 714359005731 dimerization interface [polypeptide binding]; other site 714359005732 active site 714359005733 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 714359005734 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 714359005735 folate binding site [chemical binding]; other site 714359005736 NADP+ binding site [chemical binding]; other site 714359005737 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 714359005738 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359005739 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 714359005740 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359005741 azoreductase; Reviewed; Region: PRK00170 714359005742 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 714359005743 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 714359005744 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 714359005745 putative acyl-acceptor binding pocket; other site 714359005746 Haemolysin-III related; Region: HlyIII; cl03831 714359005747 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 714359005748 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 714359005749 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 714359005750 EDD domain protein, DegV family; Region: DegV; TIGR00762 714359005751 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 714359005752 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 714359005753 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 714359005754 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 714359005755 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 714359005756 Cu(I) binding site [ion binding]; other site 714359005757 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 714359005758 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 714359005759 putative dimer interface [polypeptide binding]; other site 714359005760 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 714359005761 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 714359005762 active site 714359005763 dimer interface [polypeptide binding]; other site 714359005764 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 714359005765 Ligand Binding Site [chemical binding]; other site 714359005766 Molecular Tunnel; other site 714359005767 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359005768 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 714359005769 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714359005770 active site 714359005771 metal binding site [ion binding]; metal-binding site 714359005772 Bacterial SH3 domain; Region: SH3_3; cl17532 714359005773 Bacterial SH3 domain; Region: SH3_3; cl17532 714359005774 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 714359005775 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 714359005776 siderophore binding site; other site 714359005777 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 714359005778 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 714359005779 homodimer interface [polypeptide binding]; other site 714359005780 substrate-cofactor binding pocket; other site 714359005781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359005782 catalytic residue [active] 714359005783 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 714359005784 FMN binding site [chemical binding]; other site 714359005785 dimer interface [polypeptide binding]; other site 714359005786 Isochorismatase family; Region: Isochorismatase; pfam00857 714359005787 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 714359005788 catalytic triad [active] 714359005789 conserved cis-peptide bond; other site 714359005790 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 714359005791 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 714359005792 putative dimer interface [polypeptide binding]; other site 714359005793 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 714359005794 Mechanosensitive ion channel; Region: MS_channel; pfam00924 714359005795 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 714359005796 GAF domain; Region: GAF; pfam01590 714359005797 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 714359005798 Histidine kinase; Region: HisKA_3; pfam07730 714359005799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359005800 ATP binding site [chemical binding]; other site 714359005801 Mg2+ binding site [ion binding]; other site 714359005802 G-X-G motif; other site 714359005803 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359005804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359005805 active site 714359005806 phosphorylation site [posttranslational modification] 714359005807 intermolecular recognition site; other site 714359005808 dimerization interface [polypeptide binding]; other site 714359005809 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359005810 DNA binding residues [nucleotide binding] 714359005811 dimerization interface [polypeptide binding]; other site 714359005812 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 714359005813 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 714359005814 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 714359005815 putative active site [active] 714359005816 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 714359005817 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 714359005818 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 714359005819 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 714359005820 NAD binding site [chemical binding]; other site 714359005821 substrate binding site [chemical binding]; other site 714359005822 catalytic Zn binding site [ion binding]; other site 714359005823 tetramer interface [polypeptide binding]; other site 714359005824 structural Zn binding site [ion binding]; other site 714359005825 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 714359005826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359005827 dimer interface [polypeptide binding]; other site 714359005828 conserved gate region; other site 714359005829 ABC-ATPase subunit interface; other site 714359005830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359005831 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 714359005832 dimer interface [polypeptide binding]; other site 714359005833 conserved gate region; other site 714359005834 putative PBP binding loops; other site 714359005835 ABC-ATPase subunit interface; other site 714359005836 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 714359005837 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 714359005838 N- and C-terminal domain interface [polypeptide binding]; other site 714359005839 active site 714359005840 catalytic site [active] 714359005841 metal binding site [ion binding]; metal-binding site 714359005842 carbohydrate binding site [chemical binding]; other site 714359005843 ATP binding site [chemical binding]; other site 714359005844 fructuronate transporter; Provisional; Region: PRK10034; cl15264 714359005845 GntP family permease; Region: GntP_permease; pfam02447 714359005846 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 714359005847 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 714359005848 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 714359005849 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 714359005850 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359005851 active site 714359005852 Predicted flavoprotein [General function prediction only]; Region: COG0431 714359005853 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 714359005854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359005855 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359005856 putative substrate translocation pore; other site 714359005857 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714359005858 Uncharacterized conserved protein [Function unknown]; Region: COG1434 714359005859 putative active site [active] 714359005860 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 714359005861 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 714359005862 Walker A/P-loop; other site 714359005863 ATP binding site [chemical binding]; other site 714359005864 Q-loop/lid; other site 714359005865 ABC transporter signature motif; other site 714359005866 Walker B; other site 714359005867 D-loop; other site 714359005868 H-loop/switch region; other site 714359005869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 714359005870 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 714359005871 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 714359005872 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 714359005873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 714359005874 Protein of unknown function (DUF524); Region: DUF524; pfam04411 714359005875 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 714359005876 Helix-turn-helix domain; Region: HTH_17; pfam12728 714359005877 Haemagglutinin; Region: Hemagglutinin; pfam00509 714359005878 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 714359005879 Domain of unknown function DUF21; Region: DUF21; pfam01595 714359005880 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714359005881 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 714359005882 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 714359005883 NAD(P) binding site [chemical binding]; other site 714359005884 catalytic residues [active] 714359005885 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 714359005886 Histidine kinase N terminal; Region: HisK_N; pfam09385 714359005887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359005888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359005889 dimer interface [polypeptide binding]; other site 714359005890 phosphorylation site [posttranslational modification] 714359005891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359005892 ATP binding site [chemical binding]; other site 714359005893 Mg2+ binding site [ion binding]; other site 714359005894 G-X-G motif; other site 714359005895 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 714359005896 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 714359005897 hypothetical protein; Provisional; Region: PRK06917 714359005898 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359005899 inhibitor-cofactor binding pocket; inhibition site 714359005900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359005901 catalytic residue [active] 714359005902 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 714359005903 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 714359005904 acetylornithine deacetylase; Validated; Region: PRK06915 714359005905 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 714359005906 metal binding site [ion binding]; metal-binding site 714359005907 dimer interface [polypeptide binding]; other site 714359005908 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 714359005909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005910 Coenzyme A binding pocket [chemical binding]; other site 714359005911 PAS fold; Region: PAS_4; pfam08448 714359005912 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 714359005913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359005914 Walker A motif; other site 714359005915 ATP binding site [chemical binding]; other site 714359005916 Walker B motif; other site 714359005917 arginine finger; other site 714359005918 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 714359005919 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 714359005920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359005921 FeS/SAM binding site; other site 714359005922 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 714359005923 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 714359005924 toxin interface [polypeptide binding]; other site 714359005925 Zn binding site [ion binding]; other site 714359005926 hypothetical protein; Provisional; Region: PRK13672 714359005927 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 714359005928 YozD-like protein; Region: YozD; pfam14162 714359005929 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 714359005930 Catalytic domain of Protein Kinases; Region: PKc; cd00180 714359005931 active site 714359005932 ATP binding site [chemical binding]; other site 714359005933 substrate binding site [chemical binding]; other site 714359005934 activation loop (A-loop); other site 714359005935 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 714359005936 SpoOM protein; Region: Spo0M; pfam07070 714359005937 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 714359005938 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 714359005939 active site 714359005940 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 714359005941 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 714359005942 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359005943 catalytic residues [active] 714359005944 C1q domain; Region: C1q; cl17543 714359005945 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 714359005946 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 714359005947 active site 714359005948 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 714359005949 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 714359005950 YolD-like protein; Region: YolD; pfam08863 714359005951 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 714359005952 classical (c) SDRs; Region: SDR_c; cd05233 714359005953 NAD(P) binding site [chemical binding]; other site 714359005954 active site 714359005955 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 714359005956 Transglycosylase; Region: Transgly; pfam00912 714359005957 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 714359005958 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359005959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359005960 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359005961 putative substrate translocation pore; other site 714359005962 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 714359005963 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 714359005964 dimer interface [polypeptide binding]; other site 714359005965 Citrate synthase; Region: Citrate_synt; pfam00285 714359005966 active site 714359005967 coenzyme A binding site [chemical binding]; other site 714359005968 citrylCoA binding site [chemical binding]; other site 714359005969 oxalacetate/citrate binding site [chemical binding]; other site 714359005970 catalytic triad [active] 714359005971 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 714359005972 2-methylcitrate dehydratase; Region: prpD; TIGR02330 714359005973 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 714359005974 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 714359005975 tetramer interface [polypeptide binding]; other site 714359005976 active site 714359005977 Mg2+/Mn2+ binding site [ion binding]; other site 714359005978 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 714359005979 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 714359005980 active site 714359005981 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 714359005982 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 714359005983 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 714359005984 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 714359005985 tetrameric interface [polypeptide binding]; other site 714359005986 NAD binding site [chemical binding]; other site 714359005987 catalytic residues [active] 714359005988 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 714359005989 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 714359005990 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714359005991 substrate binding site [chemical binding]; other site 714359005992 oxyanion hole (OAH) forming residues; other site 714359005993 trimer interface [polypeptide binding]; other site 714359005994 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 714359005995 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 714359005996 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 714359005997 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 714359005998 active site 714359005999 metal binding site [ion binding]; metal-binding site 714359006000 DNA binding site [nucleotide binding] 714359006001 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 714359006002 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 714359006003 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 714359006004 Walker A/P-loop; other site 714359006005 ATP binding site [chemical binding]; other site 714359006006 Q-loop/lid; other site 714359006007 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 714359006008 ABC transporter signature motif; other site 714359006009 Walker B; other site 714359006010 D-loop; other site 714359006011 H-loop/switch region; other site 714359006012 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359006013 dimerization interface [polypeptide binding]; other site 714359006014 putative DNA binding site [nucleotide binding]; other site 714359006015 putative Zn2+ binding site [ion binding]; other site 714359006016 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 714359006017 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 714359006018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006019 putative substrate translocation pore; other site 714359006020 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 714359006021 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 714359006022 putative NAD(P) binding site [chemical binding]; other site 714359006023 active site 714359006024 isochorismate synthase DhbC; Validated; Region: PRK06923 714359006025 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 714359006026 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 714359006027 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 714359006028 acyl-activating enzyme (AAE) consensus motif; other site 714359006029 active site 714359006030 AMP binding site [chemical binding]; other site 714359006031 substrate binding site [chemical binding]; other site 714359006032 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 714359006033 hydrophobic substrate binding pocket; other site 714359006034 Isochorismatase family; Region: Isochorismatase; pfam00857 714359006035 active site 714359006036 conserved cis-peptide bond; other site 714359006037 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 714359006038 Condensation domain; Region: Condensation; pfam00668 714359006039 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 714359006040 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 714359006041 acyl-activating enzyme (AAE) consensus motif; other site 714359006042 AMP binding site [chemical binding]; other site 714359006043 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359006044 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 714359006045 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 714359006046 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 714359006047 acyl-activating enzyme (AAE) consensus motif; other site 714359006048 AMP binding site [chemical binding]; other site 714359006049 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359006050 MbtH-like protein; Region: MbtH; pfam03621 714359006051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006052 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359006053 putative substrate translocation pore; other site 714359006054 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 714359006055 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 714359006056 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 714359006057 IHF dimer interface [polypeptide binding]; other site 714359006058 IHF - DNA interface [nucleotide binding]; other site 714359006059 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 714359006060 DinB family; Region: DinB; cl17821 714359006061 DinB superfamily; Region: DinB_2; pfam12867 714359006062 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 714359006063 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 714359006064 active site 714359006065 catalytic triad [active] 714359006066 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 714359006067 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 714359006068 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 714359006069 metal binding triad [ion binding]; metal-binding site 714359006070 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 714359006071 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 714359006072 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359006073 RNA binding surface [nucleotide binding]; other site 714359006074 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 714359006075 probable active site [active] 714359006076 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 714359006077 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 714359006078 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 714359006079 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 714359006080 active site 714359006081 dimer interface [polypeptide binding]; other site 714359006082 motif 1; other site 714359006083 motif 2; other site 714359006084 motif 3; other site 714359006085 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 714359006086 anticodon binding site; other site 714359006087 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359006088 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714359006089 Walker A/P-loop; other site 714359006090 ATP binding site [chemical binding]; other site 714359006091 Q-loop/lid; other site 714359006092 ABC transporter signature motif; other site 714359006093 Walker B; other site 714359006094 D-loop; other site 714359006095 H-loop/switch region; other site 714359006096 FtsX-like permease family; Region: FtsX; pfam02687 714359006097 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 714359006098 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359006099 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 714359006100 active site 714359006101 dimerization interface [polypeptide binding]; other site 714359006102 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 714359006103 Protein of unknown function, DUF606; Region: DUF606; pfam04657 714359006104 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 714359006105 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714359006106 ligand binding site [chemical binding]; other site 714359006107 flexible hinge region; other site 714359006108 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 714359006109 Protein of unknown function, DUF606; Region: DUF606; pfam04657 714359006110 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359006111 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359006112 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359006113 MMPL family; Region: MMPL; pfam03176 714359006114 MMPL family; Region: MMPL; pfam03176 714359006115 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 714359006116 Probable transposase; Region: OrfB_IS605; pfam01385 714359006117 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714359006118 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 714359006119 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 714359006120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006121 Coenzyme A binding pocket [chemical binding]; other site 714359006122 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 714359006123 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 714359006124 putative acetyltransferase YhhY; Provisional; Region: PRK10140 714359006125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006126 Coenzyme A binding pocket [chemical binding]; other site 714359006127 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714359006128 EamA-like transporter family; Region: EamA; pfam00892 714359006129 EamA-like transporter family; Region: EamA; pfam00892 714359006130 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 714359006131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359006132 non-specific DNA binding site [nucleotide binding]; other site 714359006133 salt bridge; other site 714359006134 sequence-specific DNA binding site [nucleotide binding]; other site 714359006135 Cupin domain; Region: Cupin_2; pfam07883 714359006136 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 714359006137 protoporphyrinogen oxidase; Provisional; Region: PRK12416 714359006138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 714359006139 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359006140 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359006141 Cold-inducible protein YdjO; Region: YdjO; pfam14169 714359006142 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714359006143 DNA-binding site [nucleotide binding]; DNA binding site 714359006144 RNA-binding motif; other site 714359006145 CAAX protease self-immunity; Region: Abi; pfam02517 714359006146 AAA domain; Region: AAA_17; pfam13207 714359006147 AAA domain; Region: AAA_18; pfam13238 714359006148 hypothetical protein; Provisional; Region: PRK06770 714359006149 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359006150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359006151 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359006152 dimerization interface [polypeptide binding]; other site 714359006153 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 714359006154 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 714359006155 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 714359006156 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 714359006157 active site 714359006158 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 714359006159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359006160 dimerization interface [polypeptide binding]; other site 714359006161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 714359006162 MOSC domain; Region: MOSC; pfam03473 714359006163 3-alpha domain; Region: 3-alpha; pfam03475 714359006164 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 714359006165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006166 Coenzyme A binding pocket [chemical binding]; other site 714359006167 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714359006168 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359006169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359006170 Walker A/P-loop; other site 714359006171 ATP binding site [chemical binding]; other site 714359006172 Q-loop/lid; other site 714359006173 ABC transporter signature motif; other site 714359006174 Walker B; other site 714359006175 D-loop; other site 714359006176 H-loop/switch region; other site 714359006177 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714359006178 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359006179 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 714359006180 Walker A/P-loop; other site 714359006181 ATP binding site [chemical binding]; other site 714359006182 Q-loop/lid; other site 714359006183 ABC transporter signature motif; other site 714359006184 Walker B; other site 714359006185 D-loop; other site 714359006186 H-loop/switch region; other site 714359006187 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 714359006188 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 714359006189 LysE type translocator; Region: LysE; cl00565 714359006190 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 714359006191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359006192 non-specific DNA binding site [nucleotide binding]; other site 714359006193 salt bridge; other site 714359006194 sequence-specific DNA binding site [nucleotide binding]; other site 714359006195 Cupin domain; Region: Cupin_2; pfam07883 714359006196 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 714359006197 BclB C-terminal domain; Region: exospore_TM; TIGR03721 714359006198 Cupin; Region: Cupin_1; smart00835 714359006199 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 714359006200 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 714359006201 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 714359006202 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359006203 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 714359006204 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 714359006205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359006206 S-adenosylmethionine binding site [chemical binding]; other site 714359006207 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 714359006208 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 714359006209 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 714359006210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 714359006211 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 714359006212 active site 714359006213 P-loop; other site 714359006214 phosphorylation site [posttranslational modification] 714359006215 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 714359006216 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 714359006217 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 714359006218 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 714359006219 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 714359006220 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 714359006221 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 714359006222 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 714359006223 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359006224 catalytic residue [active] 714359006225 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 714359006226 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 714359006227 tetramer interface [polypeptide binding]; other site 714359006228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359006229 catalytic residue [active] 714359006230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006231 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359006232 putative substrate translocation pore; other site 714359006233 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359006234 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 714359006235 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714359006236 ATP binding site [chemical binding]; other site 714359006237 Mg++ binding site [ion binding]; other site 714359006238 motif III; other site 714359006239 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359006240 nucleotide binding region [chemical binding]; other site 714359006241 ATP-binding site [chemical binding]; other site 714359006242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359006243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359006244 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359006245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006246 putative substrate translocation pore; other site 714359006247 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 714359006248 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 714359006249 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 714359006250 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 714359006251 Int/Topo IB signature motif; other site 714359006252 M6 family metalloprotease domain; Region: M6dom_TIGR03296 714359006253 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 714359006254 sugar binding site [chemical binding]; other site 714359006255 putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633 714359006256 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 714359006257 Methyltransferase domain; Region: Methyltransf_31; pfam13847 714359006258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359006259 S-adenosylmethionine binding site [chemical binding]; other site 714359006260 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 714359006261 dimer interface [polypeptide binding]; other site 714359006262 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 714359006263 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 714359006264 dimer interface [polypeptide binding]; other site 714359006265 PYR/PP interface [polypeptide binding]; other site 714359006266 TPP binding site [chemical binding]; other site 714359006267 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 714359006268 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 714359006269 TPP-binding site [chemical binding]; other site 714359006270 dimer interface [polypeptide binding]; other site 714359006271 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359006272 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359006273 putative DNA binding site [nucleotide binding]; other site 714359006274 putative Zn2+ binding site [ion binding]; other site 714359006275 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359006276 catalytic core [active] 714359006277 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359006278 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 714359006279 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 714359006280 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 714359006281 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 714359006282 metal binding site [ion binding]; metal-binding site 714359006283 dimer interface [polypeptide binding]; other site 714359006284 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 714359006285 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359006286 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359006287 DNA binding residues [nucleotide binding] 714359006288 dimerization interface [polypeptide binding]; other site 714359006289 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359006290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359006291 non-specific DNA binding site [nucleotide binding]; other site 714359006292 salt bridge; other site 714359006293 sequence-specific DNA binding site [nucleotide binding]; other site 714359006294 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359006295 hypothetical protein; Provisional; Region: PRK10621 714359006296 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359006297 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 714359006298 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 714359006299 trimer interface [polypeptide binding]; other site 714359006300 active site 714359006301 substrate binding site [chemical binding]; other site 714359006302 CoA binding site [chemical binding]; other site 714359006303 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359006304 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714359006305 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 714359006306 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 714359006307 active site 714359006308 catalytic triad [active] 714359006309 oxyanion hole [active] 714359006310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006311 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359006312 putative substrate translocation pore; other site 714359006313 Condensation domain; Region: Condensation; pfam00668 714359006314 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714359006315 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 714359006316 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 714359006317 acyl-activating enzyme (AAE) consensus motif; other site 714359006318 AMP binding site [chemical binding]; other site 714359006319 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359006320 Condensation domain; Region: Condensation; pfam00668 714359006321 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 714359006322 Condensation domain; Region: Condensation; pfam00668 714359006323 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714359006324 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 714359006325 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 714359006326 acyl-activating enzyme (AAE) consensus motif; other site 714359006327 AMP binding site [chemical binding]; other site 714359006328 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359006329 Condensation domain; Region: Condensation; pfam00668 714359006330 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714359006331 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 714359006332 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 714359006333 acyl-activating enzyme (AAE) consensus motif; other site 714359006334 AMP binding site [chemical binding]; other site 714359006335 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359006336 Condensation domain; Region: Condensation; pfam00668 714359006337 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714359006338 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 714359006339 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 714359006340 acyl-activating enzyme (AAE) consensus motif; other site 714359006341 AMP binding site [chemical binding]; other site 714359006342 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359006343 peptide synthase; Provisional; Region: PRK12467 714359006344 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 714359006345 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 714359006346 acyl-activating enzyme (AAE) consensus motif; other site 714359006347 AMP binding site [chemical binding]; other site 714359006348 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359006349 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 714359006350 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 714359006351 acyl-activating enzyme (AAE) consensus motif; other site 714359006352 AMP binding site [chemical binding]; other site 714359006353 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359006354 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 714359006355 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 714359006356 acyl-activating enzyme (AAE) consensus motif; other site 714359006357 AMP binding site [chemical binding]; other site 714359006358 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359006359 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 714359006360 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 714359006361 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 714359006362 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 714359006363 Erythromycin esterase; Region: Erythro_esteras; cl17110 714359006364 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 714359006365 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714359006366 catalytic residue [active] 714359006367 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359006368 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359006369 Coenzyme A binding pocket [chemical binding]; other site 714359006370 S-layer homology domain; Region: SLH; pfam00395 714359006371 S-layer homology domain; Region: SLH; pfam00395 714359006372 S-layer homology domain; Region: SLH; pfam00395 714359006373 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 714359006374 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 714359006375 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 714359006376 active site 714359006377 nucleophile elbow; other site 714359006378 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 714359006379 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 714359006380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359006381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359006382 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 714359006383 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 714359006384 FOG: PKD repeat [General function prediction only]; Region: COG3291 714359006385 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 714359006386 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 714359006387 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359006388 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714359006389 Walker A/P-loop; other site 714359006390 ATP binding site [chemical binding]; other site 714359006391 Q-loop/lid; other site 714359006392 ABC transporter signature motif; other site 714359006393 Walker B; other site 714359006394 D-loop; other site 714359006395 H-loop/switch region; other site 714359006396 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359006397 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359006398 S-layer homology domain; Region: SLH; pfam00395 714359006399 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359006400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359006401 active site 714359006402 phosphorylation site [posttranslational modification] 714359006403 intermolecular recognition site; other site 714359006404 dimerization interface [polypeptide binding]; other site 714359006405 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359006406 DNA binding residues [nucleotide binding] 714359006407 dimerization interface [polypeptide binding]; other site 714359006408 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359006409 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359006410 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 714359006411 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359006412 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 714359006413 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359006414 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 714359006415 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359006416 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359006417 DNA binding residues [nucleotide binding] 714359006418 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 714359006419 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359006420 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359006421 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 714359006422 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359006423 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359006424 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359006425 beta-lactamase TEM; Provisional; Region: PRK15442 714359006426 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 714359006427 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 714359006428 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359006429 putative active site [active] 714359006430 putative metal binding site [ion binding]; other site 714359006431 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714359006432 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 714359006433 Walker A/P-loop; other site 714359006434 ATP binding site [chemical binding]; other site 714359006435 Q-loop/lid; other site 714359006436 ABC transporter signature motif; other site 714359006437 Walker B; other site 714359006438 D-loop; other site 714359006439 H-loop/switch region; other site 714359006440 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 714359006441 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 714359006442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359006443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359006444 Protein of unknown function (DUF523); Region: DUF523; pfam04463 714359006445 Uncharacterized conserved protein [Function unknown]; Region: COG3272 714359006446 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 714359006447 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 714359006448 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 714359006449 FAD binding site [chemical binding]; other site 714359006450 homotetramer interface [polypeptide binding]; other site 714359006451 substrate binding pocket [chemical binding]; other site 714359006452 catalytic base [active] 714359006453 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 714359006454 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714359006455 ATP-grasp domain; Region: ATP-grasp_4; cl17255 714359006456 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 714359006457 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 714359006458 carboxyltransferase (CT) interaction site; other site 714359006459 biotinylation site [posttranslational modification]; other site 714359006460 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 714359006461 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 714359006462 active site 714359006463 catalytic residues [active] 714359006464 metal binding site [ion binding]; metal-binding site 714359006465 enoyl-CoA hydratase; Provisional; Region: PRK07657 714359006466 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714359006467 substrate binding site [chemical binding]; other site 714359006468 oxyanion hole (OAH) forming residues; other site 714359006469 trimer interface [polypeptide binding]; other site 714359006470 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 714359006471 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 714359006472 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 714359006473 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 714359006474 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 714359006475 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 714359006476 acyl-activating enzyme (AAE) consensus motif; other site 714359006477 putative AMP binding site [chemical binding]; other site 714359006478 putative active site [active] 714359006479 putative CoA binding site [chemical binding]; other site 714359006480 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359006481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006482 Coenzyme A binding pocket [chemical binding]; other site 714359006483 hypothetical protein; Provisional; Region: PRK08233 714359006484 AAA domain; Region: AAA_18; pfam13238 714359006485 active site 714359006486 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359006487 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 714359006488 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 714359006489 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714359006490 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359006491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359006492 dimer interface [polypeptide binding]; other site 714359006493 phosphorylation site [posttranslational modification] 714359006494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359006495 ATP binding site [chemical binding]; other site 714359006496 Mg2+ binding site [ion binding]; other site 714359006497 G-X-G motif; other site 714359006498 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359006499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359006500 active site 714359006501 phosphorylation site [posttranslational modification] 714359006502 intermolecular recognition site; other site 714359006503 dimerization interface [polypeptide binding]; other site 714359006504 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359006505 DNA binding site [nucleotide binding] 714359006506 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359006507 Zn2+ binding site [ion binding]; other site 714359006508 Mg2+ binding site [ion binding]; other site 714359006509 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 714359006510 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 714359006511 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006512 Coenzyme A binding pocket [chemical binding]; other site 714359006513 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 714359006514 Coenzyme A binding pocket [chemical binding]; other site 714359006515 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359006516 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359006517 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 714359006518 active site 714359006519 Zn binding site [ion binding]; other site 714359006520 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 714359006521 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 714359006522 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714359006523 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359006524 Cna protein B-type domain; Region: Cna_B; pfam05738 714359006525 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359006526 Cna protein B-type domain; Region: Cna_B; pfam05738 714359006527 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 714359006528 active site 714359006529 catalytic site [active] 714359006530 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 714359006531 Cna protein B-type domain; Region: Cna_B; pfam05738 714359006532 Cna protein B-type domain; Region: Cna_B; pfam05738 714359006533 Cna protein B-type domain; Region: Cna_B; pfam05738 714359006534 Cna protein B-type domain; Region: Cna_B; pfam05738 714359006535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 714359006536 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 714359006537 putative hydrophobic ligand binding site [chemical binding]; other site 714359006538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359006539 AAA domain; Region: AAA_21; pfam13304 714359006540 Walker A/P-loop; other site 714359006541 ATP binding site [chemical binding]; other site 714359006542 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 714359006543 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 714359006544 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 714359006545 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 714359006546 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 714359006547 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359006548 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359006549 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 714359006550 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 714359006551 DNA binding residues [nucleotide binding] 714359006552 drug binding residues [chemical binding]; other site 714359006553 dimer interface [polypeptide binding]; other site 714359006554 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 714359006555 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359006556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006557 putative substrate translocation pore; other site 714359006558 short chain dehydrogenase; Provisional; Region: PRK07041 714359006559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359006560 NAD(P) binding site [chemical binding]; other site 714359006561 active site 714359006562 Predicted transcriptional regulators [Transcription]; Region: COG1733 714359006563 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 714359006564 Methyltransferase domain; Region: Methyltransf_31; pfam13847 714359006565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359006566 S-adenosylmethionine binding site [chemical binding]; other site 714359006567 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 714359006568 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359006569 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 714359006570 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359006571 active site 714359006572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359006573 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359006574 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359006575 dimerization interface [polypeptide binding]; other site 714359006576 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 714359006577 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 714359006578 active site 714359006579 Zn binding site [ion binding]; other site 714359006580 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 714359006581 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359006582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359006583 DNA-binding site [nucleotide binding]; DNA binding site 714359006584 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359006585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359006586 homodimer interface [polypeptide binding]; other site 714359006587 catalytic residue [active] 714359006588 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 714359006589 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 714359006590 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 714359006591 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714359006592 Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240 714359006593 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 714359006594 putative NAD(P) binding site [chemical binding]; other site 714359006595 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359006596 extended (e) SDRs; Region: SDR_e; cd08946 714359006597 NAD(P) binding site [chemical binding]; other site 714359006598 active site 714359006599 substrate binding site [chemical binding]; other site 714359006600 Predicted membrane protein [Function unknown]; Region: COG2323 714359006601 Methyltransferase domain; Region: Methyltransf_31; pfam13847 714359006602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359006603 S-adenosylmethionine binding site [chemical binding]; other site 714359006604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359006605 S-adenosylmethionine binding site [chemical binding]; other site 714359006606 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 714359006607 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 714359006608 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 714359006609 active site 714359006610 HIGH motif; other site 714359006611 KMSKS motif; other site 714359006612 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 714359006613 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359006614 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359006615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359006616 active site 714359006617 phosphorylation site [posttranslational modification] 714359006618 intermolecular recognition site; other site 714359006619 dimerization interface [polypeptide binding]; other site 714359006620 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359006621 DNA binding site [nucleotide binding] 714359006622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359006623 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 714359006624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359006625 ATP binding site [chemical binding]; other site 714359006626 Mg2+ binding site [ion binding]; other site 714359006627 G-X-G motif; other site 714359006628 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 714359006629 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359006630 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359006631 ABC transporter; Region: ABC_tran_2; pfam12848 714359006632 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359006633 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359006634 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359006635 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714359006636 Walker A/P-loop; other site 714359006637 ATP binding site [chemical binding]; other site 714359006638 Q-loop/lid; other site 714359006639 ABC transporter signature motif; other site 714359006640 Walker B; other site 714359006641 D-loop; other site 714359006642 H-loop/switch region; other site 714359006643 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 714359006644 FtsX-like permease family; Region: FtsX; pfam02687 714359006645 hypothetical protein; Provisional; Region: PRK06760 714359006646 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 714359006647 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 714359006648 homoserine dehydrogenase; Validated; Region: PRK06813 714359006649 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 714359006650 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359006651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359006652 DNA-binding site [nucleotide binding]; DNA binding site 714359006653 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359006654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359006655 homodimer interface [polypeptide binding]; other site 714359006656 catalytic residue [active] 714359006657 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 714359006658 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 714359006659 ATP-grasp domain; Region: ATP-grasp_4; cl17255 714359006660 Putative transcription activator [Transcription]; Region: TenA; COG0819 714359006661 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 714359006662 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 714359006663 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 714359006664 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 714359006665 Int/Topo IB signature motif; other site 714359006666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359006667 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359006668 non-specific DNA binding site [nucleotide binding]; other site 714359006669 salt bridge; other site 714359006670 sequence-specific DNA binding site [nucleotide binding]; other site 714359006671 Helix-turn-helix domain; Region: HTH_17; pfam12728 714359006672 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 714359006673 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 714359006674 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 714359006675 putative metal binding site [ion binding]; other site 714359006676 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 714359006677 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 714359006678 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 714359006679 cofactor binding site; other site 714359006680 DNA binding site [nucleotide binding] 714359006681 substrate interaction site [chemical binding]; other site 714359006682 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 714359006683 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 714359006684 Int/Topo IB signature motif; other site 714359006685 Predicted membrane protein [Function unknown]; Region: COG2323 714359006686 HNH endonuclease; Region: HNH; pfam01844 714359006687 active site 714359006688 Phage terminase, small subunit; Region: Terminase_4; cl01525 714359006689 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 714359006690 Phage-related protein [Function unknown]; Region: COG4695; cl01923 714359006691 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 714359006692 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 714359006693 oligomer interface [polypeptide binding]; other site 714359006694 active site residues [active] 714359006695 Phage capsid family; Region: Phage_capsid; pfam05065 714359006696 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 714359006697 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 714359006698 Phage-related minor tail protein [Function unknown]; Region: COG5280 714359006699 membrane protein P6; Region: PHA01399 714359006700 membrane protein P6; Region: PHA01399 714359006701 Phage tail protein; Region: Sipho_tail; pfam05709 714359006702 Phage tail protein; Region: Sipho_tail; cl17486 714359006703 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 714359006704 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 714359006705 Holin family; Region: Phage_holin_4; pfam05105 714359006706 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 714359006707 amidase catalytic site [active] 714359006708 Zn binding residues [ion binding]; other site 714359006709 substrate binding site [chemical binding]; other site 714359006710 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359006711 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359006712 Cytochrome P450; Region: p450; cl12078 714359006713 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 714359006714 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359006715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 714359006716 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 714359006717 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 714359006718 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 714359006719 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 714359006720 Protein of unknown function; Region: DUF3658; pfam12395 714359006721 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 714359006722 Cytochrome P450; Region: p450; cl12078 714359006723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006724 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359006725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006726 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 714359006727 trimer interface [polypeptide binding]; other site 714359006728 active site 714359006729 substrate binding site [chemical binding]; other site 714359006730 CoA binding site [chemical binding]; other site 714359006731 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 714359006732 Predicted transcriptional regulators [Transcription]; Region: COG1695 714359006733 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 714359006734 Cytochrome P450; Region: p450; cl12078 714359006735 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 714359006736 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 714359006737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359006738 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359006739 active site 714359006740 motif I; other site 714359006741 motif II; other site 714359006742 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359006743 PAS domain S-box; Region: sensory_box; TIGR00229 714359006744 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359006745 putative active site [active] 714359006746 heme pocket [chemical binding]; other site 714359006747 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 714359006748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359006749 dimer interface [polypeptide binding]; other site 714359006750 phosphorylation site [posttranslational modification] 714359006751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359006752 ATP binding site [chemical binding]; other site 714359006753 Mg2+ binding site [ion binding]; other site 714359006754 G-X-G motif; other site 714359006755 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 714359006756 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359006757 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359006758 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359006759 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714359006760 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359006761 Catalytic site [active] 714359006762 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 714359006763 glycosyltransferase, MGT family; Region: MGT; TIGR01426 714359006764 active site 714359006765 TDP-binding site; other site 714359006766 acceptor substrate-binding pocket; other site 714359006767 homodimer interface [polypeptide binding]; other site 714359006768 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 714359006769 aspartate racemase; Region: asp_race; TIGR00035 714359006770 hypothetical protein; Provisional; Region: PRK13661 714359006771 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714359006772 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 714359006773 Walker A/P-loop; other site 714359006774 ATP binding site [chemical binding]; other site 714359006775 Q-loop/lid; other site 714359006776 ABC transporter signature motif; other site 714359006777 Walker B; other site 714359006778 D-loop; other site 714359006779 H-loop/switch region; other site 714359006780 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 714359006781 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714359006782 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 714359006783 Walker A/P-loop; other site 714359006784 ATP binding site [chemical binding]; other site 714359006785 Q-loop/lid; other site 714359006786 ABC transporter signature motif; other site 714359006787 Walker B; other site 714359006788 D-loop; other site 714359006789 H-loop/switch region; other site 714359006790 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 714359006791 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 714359006792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359006793 dimer interface [polypeptide binding]; other site 714359006794 phosphorylation site [posttranslational modification] 714359006795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359006796 ATP binding site [chemical binding]; other site 714359006797 Mg2+ binding site [ion binding]; other site 714359006798 G-X-G motif; other site 714359006799 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 714359006800 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 714359006801 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714359006802 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 714359006803 NAD(P) binding site [chemical binding]; other site 714359006804 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 714359006805 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 714359006806 active site 714359006807 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 714359006808 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359006809 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359006810 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 714359006811 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 714359006812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006813 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359006814 putative substrate translocation pore; other site 714359006815 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359006816 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359006817 VanZ like family; Region: VanZ; pfam04892 714359006818 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 714359006819 EDD domain protein, DegV family; Region: DegV; TIGR00762 714359006820 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 714359006821 Putative amidotransferase; Region: DUF4066; pfam13278 714359006822 conserved cys residue [active] 714359006823 Predicted transcriptional regulator [Transcription]; Region: COG2378 714359006824 HTH domain; Region: HTH_11; pfam08279 714359006825 WYL domain; Region: WYL; pfam13280 714359006826 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 714359006827 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 714359006828 conserved cys residue [active] 714359006829 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 714359006830 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 714359006831 DNA binding residues [nucleotide binding] 714359006832 putative dimer interface [polypeptide binding]; other site 714359006833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359006834 S-adenosylmethionine binding site [chemical binding]; other site 714359006835 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359006836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006838 Coenzyme A binding pocket [chemical binding]; other site 714359006839 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 714359006840 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 714359006841 active site 714359006842 catalytic site [active] 714359006843 metal binding site [ion binding]; metal-binding site 714359006844 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 714359006845 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359006846 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359006847 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 714359006848 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359006849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359006850 DNA-binding site [nucleotide binding]; DNA binding site 714359006851 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359006852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359006853 homodimer interface [polypeptide binding]; other site 714359006854 catalytic residue [active] 714359006855 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359006856 EamA-like transporter family; Region: EamA; pfam00892 714359006857 EamA-like transporter family; Region: EamA; pfam00892 714359006858 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 714359006859 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 714359006860 active site 714359006861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006862 Coenzyme A binding pocket [chemical binding]; other site 714359006863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 714359006864 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 714359006865 nudix motif; other site 714359006866 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359006867 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359006868 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 714359006869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006870 putative substrate translocation pore; other site 714359006871 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 714359006872 Cadmium resistance transporter; Region: Cad; pfam03596 714359006873 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 714359006874 nudix motif; other site 714359006875 DNA polymerase III subunit beta; Validated; Region: PRK06673 714359006876 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 714359006877 putative DNA binding surface [nucleotide binding]; other site 714359006878 dimer interface [polypeptide binding]; other site 714359006879 beta-clamp/clamp loader binding surface; other site 714359006880 beta-clamp/translesion DNA polymerase binding surface; other site 714359006881 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 714359006882 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 714359006883 translation initiation factor IF-2; Provisional; Region: PRK14845 714359006884 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 714359006885 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 714359006886 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 714359006887 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 714359006888 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 714359006889 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 714359006890 active site 714359006891 nucleophile elbow; other site 714359006892 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 714359006893 pentamer interface [polypeptide binding]; other site 714359006894 dodecaamer interface [polypeptide binding]; other site 714359006895 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359006896 metal-dependent hydrolase; Provisional; Region: PRK13291 714359006897 DinB superfamily; Region: DinB_2; pfam12867 714359006898 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359006899 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359006900 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 714359006901 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 714359006902 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 714359006903 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 714359006904 GIY-YIG motif/motif A; other site 714359006905 active site 714359006906 catalytic site [active] 714359006907 putative DNA binding site [nucleotide binding]; other site 714359006908 metal binding site [ion binding]; metal-binding site 714359006909 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359006910 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006911 Coenzyme A binding pocket [chemical binding]; other site 714359006912 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 714359006913 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 714359006914 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714359006915 active site 714359006916 ATP binding site [chemical binding]; other site 714359006917 substrate binding site [chemical binding]; other site 714359006918 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 714359006919 nudix motif; other site 714359006920 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 714359006921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 714359006922 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714359006923 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 714359006924 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 714359006925 MepB protein; Region: MepB; pfam08877 714359006926 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 714359006927 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359006928 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359006929 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 714359006930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359006931 motif II; other site 714359006932 DinB superfamily; Region: DinB_2; pfam12867 714359006933 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 714359006934 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359006935 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 714359006936 carbohydrate binding site [chemical binding]; other site 714359006937 pullulanase, type I; Region: pulA_typeI; TIGR02104 714359006938 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 714359006939 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 714359006940 Ca binding site [ion binding]; other site 714359006941 active site 714359006942 catalytic site [active] 714359006943 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 714359006944 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359006945 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359006946 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 714359006947 active site 714359006948 Zn binding site [ion binding]; other site 714359006949 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714359006950 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 714359006951 active site 714359006952 metal binding site [ion binding]; metal-binding site 714359006953 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714359006954 DinB superfamily; Region: DinB_2; pfam12867 714359006955 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 714359006956 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 714359006957 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 714359006958 SecY translocase; Region: SecY; pfam00344 714359006959 EamA-like transporter family; Region: EamA; pfam00892 714359006960 EamA-like transporter family; Region: EamA; pfam00892 714359006961 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 714359006962 TAP-like protein; Region: Abhydrolase_4; pfam08386 714359006963 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 714359006964 Mg binding site [ion binding]; other site 714359006965 nucleotide binding site [chemical binding]; other site 714359006966 putative protofilament interface [polypeptide binding]; other site 714359006967 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 714359006968 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 714359006969 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359006970 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 714359006971 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 714359006972 germination protein YpeB; Region: spore_YpeB; TIGR02889 714359006973 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 714359006974 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 714359006975 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 714359006976 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 714359006977 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359006978 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359006979 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 714359006980 arylformamidase; Region: trp_arylform; TIGR03035 714359006981 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 714359006982 kynureninase; Region: kynureninase; TIGR01814 714359006983 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359006984 catalytic residue [active] 714359006985 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359006986 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359006987 Major royal jelly protein; Region: MRJP; pfam03022 714359006988 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 714359006989 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 714359006990 GAF domain; Region: GAF; pfam01590 714359006991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359006992 Walker A motif; other site 714359006993 ATP binding site [chemical binding]; other site 714359006994 Walker B motif; other site 714359006995 arginine finger; other site 714359006996 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 714359006997 NIPSNAP; Region: NIPSNAP; pfam07978 714359006998 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 714359006999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007000 Coenzyme A binding pocket [chemical binding]; other site 714359007001 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714359007002 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 714359007003 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714359007004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359007005 S-adenosylmethionine binding site [chemical binding]; other site 714359007006 Rrf2 family protein; Region: rrf2_super; TIGR00738 714359007007 Transcriptional regulator; Region: Rrf2; pfam02082 714359007008 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 714359007009 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 714359007010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714359007011 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714359007012 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 714359007013 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714359007014 E3 interaction surface; other site 714359007015 lipoyl attachment site [posttranslational modification]; other site 714359007016 e3 binding domain; Region: E3_binding; pfam02817 714359007017 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 714359007018 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 714359007019 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 714359007020 alpha subunit interface [polypeptide binding]; other site 714359007021 TPP binding site [chemical binding]; other site 714359007022 heterodimer interface [polypeptide binding]; other site 714359007023 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714359007024 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 714359007025 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 714359007026 tetramer interface [polypeptide binding]; other site 714359007027 TPP-binding site [chemical binding]; other site 714359007028 heterodimer interface [polypeptide binding]; other site 714359007029 phosphorylation loop region [posttranslational modification] 714359007030 DinB superfamily; Region: DinB_2; pfam12867 714359007031 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 714359007032 short chain dehydrogenase; Provisional; Region: PRK06914 714359007033 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 714359007034 NADP binding site [chemical binding]; other site 714359007035 active site 714359007036 steroid binding site; other site 714359007037 Protein phosphatase 2C; Region: PP2C_2; pfam13672 714359007038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359007039 dimer interface [polypeptide binding]; other site 714359007040 conserved gate region; other site 714359007041 putative PBP binding loops; other site 714359007042 ABC-ATPase subunit interface; other site 714359007043 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 714359007044 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 714359007045 Walker A/P-loop; other site 714359007046 ATP binding site [chemical binding]; other site 714359007047 Q-loop/lid; other site 714359007048 ABC transporter signature motif; other site 714359007049 Walker B; other site 714359007050 D-loop; other site 714359007051 H-loop/switch region; other site 714359007052 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 714359007053 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 714359007054 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 714359007055 Clp protease; Region: CLP_protease; pfam00574 714359007056 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 714359007057 oligomer interface [polypeptide binding]; other site 714359007058 active site residues [active] 714359007059 RNA polymerase factor sigma-70; Validated; Region: PRK06704 714359007060 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359007061 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 714359007062 DNA binding residues [nucleotide binding] 714359007063 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 714359007064 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 714359007065 catalytic loop [active] 714359007066 iron binding site [ion binding]; other site 714359007067 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 714359007068 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359007069 active site 714359007070 dimer interface [polypeptide binding]; other site 714359007071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007072 Coenzyme A binding pocket [chemical binding]; other site 714359007073 Chitin binding domain; Region: Chitin_bind_3; pfam03067 714359007074 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 714359007075 Interdomain contacts; other site 714359007076 Cytokine receptor motif; other site 714359007077 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 714359007078 Interdomain contacts; other site 714359007079 Cytokine receptor motif; other site 714359007080 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 714359007081 aromatic chitin/cellulose binding site residues [chemical binding]; other site 714359007082 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 714359007083 glycosyltransferase, MGT family; Region: MGT; TIGR01426 714359007084 active site 714359007085 TDP-binding site; other site 714359007086 acceptor substrate-binding pocket; other site 714359007087 homodimer interface [polypeptide binding]; other site 714359007088 Uncharacterized conserved protein [Function unknown]; Region: COG1262 714359007089 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 714359007090 topology modulation protein; Reviewed; Region: PRK08118 714359007091 AAA domain; Region: AAA_17; pfam13207 714359007092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359007093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 714359007094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007095 Coenzyme A binding pocket [chemical binding]; other site 714359007096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007097 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359007098 Coenzyme A binding pocket [chemical binding]; other site 714359007099 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 714359007100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007101 Coenzyme A binding pocket [chemical binding]; other site 714359007102 Predicted transcriptional regulators [Transcription]; Region: COG1695 714359007103 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 714359007104 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 714359007105 Part of AAA domain; Region: AAA_19; pfam13245 714359007106 Family description; Region: UvrD_C_2; pfam13538 714359007107 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 714359007108 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 714359007109 putative active site pocket [active] 714359007110 putative catalytic residue [active] 714359007111 dimerization interface [polypeptide binding]; other site 714359007112 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 714359007113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359007114 ATP binding site [chemical binding]; other site 714359007115 putative Mg++ binding site [ion binding]; other site 714359007116 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359007117 nucleotide binding region [chemical binding]; other site 714359007118 ATP-binding site [chemical binding]; other site 714359007119 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 714359007120 HRDC domain; Region: HRDC; pfam00570 714359007121 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 714359007122 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 714359007123 active site 714359007124 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 714359007125 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714359007126 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 714359007127 active site 714359007128 metal binding site [ion binding]; metal-binding site 714359007129 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 714359007130 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 714359007131 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 714359007132 DHHA2 domain; Region: DHHA2; pfam02833 714359007133 Chitin binding domain; Region: Chitin_bind_3; pfam03067 714359007134 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359007135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007136 Coenzyme A binding pocket [chemical binding]; other site 714359007137 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359007138 Zn2+ binding site [ion binding]; other site 714359007139 Mg2+ binding site [ion binding]; other site 714359007140 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 714359007141 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 714359007142 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 714359007143 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 714359007144 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 714359007145 NAD(P) binding site [chemical binding]; other site 714359007146 catalytic residues [active] 714359007147 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 714359007148 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 714359007149 inhibitor site; inhibition site 714359007150 active site 714359007151 dimer interface [polypeptide binding]; other site 714359007152 catalytic residue [active] 714359007153 Proline racemase; Region: Pro_racemase; pfam05544 714359007154 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 714359007155 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 714359007156 Proline racemase; Region: Pro_racemase; pfam05544 714359007157 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 714359007158 hydroxyglutarate oxidase; Provisional; Region: PRK11728 714359007159 PAS domain; Region: PAS_9; pfam13426 714359007160 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 714359007161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359007162 Walker A motif; other site 714359007163 ATP binding site [chemical binding]; other site 714359007164 Walker B motif; other site 714359007165 arginine finger; other site 714359007166 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 714359007167 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 714359007168 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 714359007169 catalytic loop [active] 714359007170 iron binding site [ion binding]; other site 714359007171 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 714359007172 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 714359007173 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 714359007174 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 714359007175 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 714359007176 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359007177 Zn2+ binding site [ion binding]; other site 714359007178 Mg2+ binding site [ion binding]; other site 714359007179 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714359007180 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 714359007181 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 714359007182 DltD N-terminal region; Region: DltD_N; pfam04915 714359007183 DltD central region; Region: DltD_M; pfam04918 714359007184 DltD C-terminal region; Region: DltD_C; pfam04914 714359007185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359007186 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359007187 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359007188 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359007189 peptide binding site [polypeptide binding]; other site 714359007190 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 714359007191 NlpC/P60 family; Region: NLPC_P60; pfam00877 714359007192 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 714359007193 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 714359007194 active site 714359007195 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 714359007196 Septum formation initiator; Region: DivIC; cl17659 714359007197 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 714359007198 active site 714359007199 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 714359007200 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 714359007201 conserved cys residue [active] 714359007202 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 714359007203 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 714359007204 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 714359007205 AAA domain; Region: AAA_17; pfam13207 714359007206 AAA domain; Region: AAA_18; pfam13238 714359007207 Methyltransferase domain; Region: Methyltransf_23; pfam13489 714359007208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359007209 S-adenosylmethionine binding site [chemical binding]; other site 714359007210 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 714359007211 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 714359007212 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 714359007213 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 714359007214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359007215 dimerization interface [polypeptide binding]; other site 714359007216 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359007217 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359007218 dimer interface [polypeptide binding]; other site 714359007219 phosphorylation site [posttranslational modification] 714359007220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359007221 ATP binding site [chemical binding]; other site 714359007222 Mg2+ binding site [ion binding]; other site 714359007223 G-X-G motif; other site 714359007224 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359007225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359007226 active site 714359007227 phosphorylation site [posttranslational modification] 714359007228 intermolecular recognition site; other site 714359007229 dimerization interface [polypeptide binding]; other site 714359007230 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359007231 DNA binding site [nucleotide binding] 714359007232 DinB superfamily; Region: DinB_2; pfam12867 714359007233 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359007234 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359007235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359007236 motif II; other site 714359007237 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 714359007238 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 714359007239 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 714359007240 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 714359007241 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 714359007242 Zn binding site [ion binding]; other site 714359007243 EDD domain protein, DegV family; Region: DegV; TIGR00762 714359007244 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 714359007245 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 714359007246 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 714359007247 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 714359007248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007249 Coenzyme A binding pocket [chemical binding]; other site 714359007250 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 714359007251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007252 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359007253 putative substrate translocation pore; other site 714359007254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007255 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 714359007256 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 714359007257 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 714359007258 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 714359007259 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 714359007260 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 714359007261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007262 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359007263 putative substrate translocation pore; other site 714359007264 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 714359007265 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 714359007266 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 714359007267 active site 714359007268 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 714359007269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359007270 S-adenosylmethionine binding site [chemical binding]; other site 714359007271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007272 putative substrate translocation pore; other site 714359007273 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359007274 aspartate aminotransferase; Provisional; Region: PRK07681 714359007275 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359007276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359007277 homodimer interface [polypeptide binding]; other site 714359007278 catalytic residue [active] 714359007279 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 714359007280 pantothenate kinase; Provisional; Region: PRK13317 714359007281 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 714359007282 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 714359007283 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 714359007284 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359007285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359007286 Walker A/P-loop; other site 714359007287 ATP binding site [chemical binding]; other site 714359007288 Q-loop/lid; other site 714359007289 ABC transporter signature motif; other site 714359007290 Walker B; other site 714359007291 D-loop; other site 714359007292 H-loop/switch region; other site 714359007293 Predicted transcriptional regulators [Transcription]; Region: COG1725 714359007294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359007295 DNA-binding site [nucleotide binding]; DNA binding site 714359007296 DinB family; Region: DinB; cl17821 714359007297 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 714359007298 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 714359007299 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 714359007300 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 714359007301 Domain of unknown function DUF20; Region: UPF0118; pfam01594 714359007302 HNH endonuclease; Region: HNH_5; pfam14279 714359007303 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 714359007304 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 714359007305 active site 714359007306 dimer interface [polypeptide binding]; other site 714359007307 non-prolyl cis peptide bond; other site 714359007308 insertion regions; other site 714359007309 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 714359007310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 714359007311 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 714359007312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359007313 substrate binding pocket [chemical binding]; other site 714359007314 membrane-bound complex binding site; other site 714359007315 hinge residues; other site 714359007316 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 714359007317 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 714359007318 Walker A/P-loop; other site 714359007319 ATP binding site [chemical binding]; other site 714359007320 Q-loop/lid; other site 714359007321 ABC transporter signature motif; other site 714359007322 Walker B; other site 714359007323 D-loop; other site 714359007324 H-loop/switch region; other site 714359007325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359007326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359007327 Protein of unknown function (DUF402); Region: DUF402; pfam04167 714359007328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 714359007329 binding surface 714359007330 TPR motif; other site 714359007331 hypothetical protein; Provisional; Region: PRK09620 714359007332 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 714359007333 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 714359007334 DinB superfamily; Region: DinB_2; pfam12867 714359007335 Protein of unknown function (DUF664); Region: DUF664; pfam04978 714359007336 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 714359007337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007338 Coenzyme A binding pocket [chemical binding]; other site 714359007339 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359007340 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359007341 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 714359007342 active site 714359007343 NTP binding site [chemical binding]; other site 714359007344 metal binding triad [ion binding]; metal-binding site 714359007345 antibiotic binding site [chemical binding]; other site 714359007346 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 714359007347 A new structural DNA glycosylase; Region: AlkD_like; cd06561 714359007348 active site 714359007349 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359007350 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 714359007351 active site 714359007352 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359007353 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 714359007354 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 714359007355 NodB motif; other site 714359007356 active site 714359007357 catalytic site [active] 714359007358 Zn binding site [ion binding]; other site 714359007359 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 714359007360 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 714359007361 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 714359007362 Sulfatase; Region: Sulfatase; pfam00884 714359007363 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 714359007364 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359007365 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359007366 ABC transporter; Region: ABC_tran_2; pfam12848 714359007367 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359007368 hypothetical protein; Provisional; Region: PRK06761 714359007369 MMPL family; Region: MMPL; pfam03176 714359007370 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 714359007371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359007372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359007373 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 714359007374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007375 Coenzyme A binding pocket [chemical binding]; other site 714359007376 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 714359007377 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 714359007378 hinge; other site 714359007379 active site 714359007380 prephenate dehydrogenase; Validated; Region: PRK06545 714359007381 prephenate dehydrogenase; Validated; Region: PRK08507 714359007382 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 714359007383 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 714359007384 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359007385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359007386 homodimer interface [polypeptide binding]; other site 714359007387 catalytic residue [active] 714359007388 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 714359007389 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 714359007390 Tetramer interface [polypeptide binding]; other site 714359007391 active site 714359007392 FMN-binding site [chemical binding]; other site 714359007393 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 714359007394 Chorismate mutase type II; Region: CM_2; cl00693 714359007395 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 714359007396 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 714359007397 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 714359007398 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 714359007399 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 714359007400 Isochorismatase family; Region: Isochorismatase; pfam00857 714359007401 catalytic triad [active] 714359007402 conserved cis-peptide bond; other site 714359007403 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359007404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007405 Coenzyme A binding pocket [chemical binding]; other site 714359007406 YfzA-like protein; Region: YfzA; pfam14118 714359007407 hypothetical protein; Provisional; Region: PRK06762 714359007408 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 714359007409 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359007410 putative metal binding site [ion binding]; other site 714359007411 Berberine and berberine like; Region: BBE; pfam08031 714359007412 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359007413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007414 putative substrate translocation pore; other site 714359007415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359007416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359007417 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 714359007418 malate:quinone oxidoreductase; Validated; Region: PRK05257 714359007419 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 714359007420 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 714359007421 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 714359007422 ligand binding site [chemical binding]; other site 714359007423 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714359007424 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714359007425 TM-ABC transporter signature motif; other site 714359007426 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714359007427 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714359007428 TM-ABC transporter signature motif; other site 714359007429 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 714359007430 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 714359007431 Walker A/P-loop; other site 714359007432 ATP binding site [chemical binding]; other site 714359007433 Q-loop/lid; other site 714359007434 ABC transporter signature motif; other site 714359007435 Walker B; other site 714359007436 D-loop; other site 714359007437 H-loop/switch region; other site 714359007438 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 714359007439 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 714359007440 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 714359007441 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 714359007442 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 714359007443 putative N- and C-terminal domain interface [polypeptide binding]; other site 714359007444 putative active site [active] 714359007445 putative MgATP binding site [chemical binding]; other site 714359007446 catalytic site [active] 714359007447 metal binding site [ion binding]; metal-binding site 714359007448 putative carbohydrate binding site [chemical binding]; other site 714359007449 Cupin domain; Region: Cupin_2; pfam07883 714359007450 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 714359007451 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 714359007452 putative active site; other site 714359007453 catalytic residue [active] 714359007454 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359007455 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 714359007456 active site 714359007457 metal binding site [ion binding]; metal-binding site 714359007458 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 714359007459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007460 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359007461 putative substrate translocation pore; other site 714359007462 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359007463 putative DNA binding site [nucleotide binding]; other site 714359007464 putative Zn2+ binding site [ion binding]; other site 714359007465 DinB superfamily; Region: DinB_2; pfam12867 714359007466 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714359007467 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714359007468 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359007469 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 714359007470 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 714359007471 putative catalytic cysteine [active] 714359007472 gamma-glutamyl kinase; Provisional; Region: PRK05429 714359007473 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 714359007474 nucleotide binding site [chemical binding]; other site 714359007475 homotetrameric interface [polypeptide binding]; other site 714359007476 putative phosphate binding site [ion binding]; other site 714359007477 putative allosteric binding site; other site 714359007478 PUA domain; Region: PUA; pfam01472 714359007479 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 714359007480 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 714359007481 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 714359007482 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 714359007483 putative metal binding site [ion binding]; other site 714359007484 putative dimer interface [polypeptide binding]; other site 714359007485 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 714359007486 Transcriptional regulator [Transcription]; Region: IclR; COG1414 714359007487 Bacterial transcriptional regulator; Region: IclR; pfam01614 714359007488 S-methylmethionine transporter; Provisional; Region: PRK11387 714359007489 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 714359007490 putative metal binding site [ion binding]; other site 714359007491 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359007492 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 714359007493 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 714359007494 putative di-iron ligands [ion binding]; other site 714359007495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 714359007496 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 714359007497 VanW like protein; Region: VanW; pfam04294 714359007498 Alkaline phosphatase homologues; Region: alkPPc; smart00098 714359007499 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 714359007500 active site 714359007501 dimer interface [polypeptide binding]; other site 714359007502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359007503 salt bridge; other site 714359007504 non-specific DNA binding site [nucleotide binding]; other site 714359007505 sequence-specific DNA binding site [nucleotide binding]; other site 714359007506 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 714359007507 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359007508 motif II; other site 714359007509 uridine kinase; Provisional; Region: PRK07667 714359007510 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359007511 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359007512 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359007513 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 714359007514 active site 714359007515 metal binding site [ion binding]; metal-binding site 714359007516 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 714359007517 Predicted transcriptional regulators [Transcription]; Region: COG1695 714359007518 Transcriptional regulator PadR-like family; Region: PadR; cl17335 714359007519 MoxR-like ATPases [General function prediction only]; Region: COG0714 714359007520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359007521 Walker A motif; other site 714359007522 ATP binding site [chemical binding]; other site 714359007523 Walker B motif; other site 714359007524 arginine finger; other site 714359007525 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 714359007526 Protein of unknown function DUF58; Region: DUF58; pfam01882 714359007527 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 714359007528 proline/glycine betaine transporter; Provisional; Region: PRK10642 714359007529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007530 putative substrate translocation pore; other site 714359007531 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359007532 active site 714359007533 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 714359007534 active site 714359007535 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359007536 active site 714359007537 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 714359007538 Ligand binding site; other site 714359007539 Putative Catalytic site; other site 714359007540 DXD motif; other site 714359007541 active site 714359007542 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359007543 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359007544 active site 714359007545 acetylornithine aminotransferase; Provisional; Region: PRK02627 714359007546 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359007547 inhibitor-cofactor binding pocket; inhibition site 714359007548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359007549 catalytic residue [active] 714359007550 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 714359007551 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 714359007552 heme binding pocket [chemical binding]; other site 714359007553 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 714359007554 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 714359007555 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 714359007556 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 714359007557 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 714359007558 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 714359007559 active site 714359007560 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 714359007561 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359007562 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359007563 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 714359007564 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 714359007565 Protein of unknown function DUF58; Region: DUF58; pfam01882 714359007566 MoxR-like ATPases [General function prediction only]; Region: COG0714 714359007567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359007568 Walker A motif; other site 714359007569 ATP binding site [chemical binding]; other site 714359007570 Walker B motif; other site 714359007571 arginine finger; other site 714359007572 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 714359007573 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 714359007574 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 714359007575 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 714359007576 Transposase; Region: DEDD_Tnp_IS110; pfam01548 714359007577 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 714359007578 Resolvase, N terminal domain; Region: Resolvase; smart00857 714359007579 catalytic residues [active] 714359007580 Recombinase; Region: Recombinase; pfam07508 714359007581 Uncharacterized conserved protein [Function unknown]; Region: COG5444 714359007582 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 714359007583 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 714359007584 Uncharacterized conserved protein [Function unknown]; Region: COG1359 714359007585 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 714359007586 dimer interface [polypeptide binding]; other site 714359007587 FMN binding site [chemical binding]; other site 714359007588 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359007589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359007590 putative DNA binding site [nucleotide binding]; other site 714359007591 putative Zn2+ binding site [ion binding]; other site 714359007592 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 714359007593 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 714359007594 G1 box; other site 714359007595 putative GEF interaction site [polypeptide binding]; other site 714359007596 GTP/Mg2+ binding site [chemical binding]; other site 714359007597 Switch I region; other site 714359007598 G2 box; other site 714359007599 G3 box; other site 714359007600 Switch II region; other site 714359007601 G4 box; other site 714359007602 G5 box; other site 714359007603 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 714359007604 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 714359007605 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 714359007606 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 714359007607 nudix motif; other site 714359007608 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 714359007609 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 714359007610 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 714359007611 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 714359007612 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 714359007613 putative NAD(P) binding site [chemical binding]; other site 714359007614 active site 714359007615 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359007616 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714359007617 Walker A/P-loop; other site 714359007618 ATP binding site [chemical binding]; other site 714359007619 Q-loop/lid; other site 714359007620 ABC transporter signature motif; other site 714359007621 Walker B; other site 714359007622 D-loop; other site 714359007623 H-loop/switch region; other site 714359007624 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 714359007625 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 714359007626 FtsX-like permease family; Region: FtsX; pfam02687 714359007627 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359007628 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359007629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359007630 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714359007631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359007632 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 714359007633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007634 Coenzyme A binding pocket [chemical binding]; other site 714359007635 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 714359007636 nudix motif; other site 714359007637 EamA-like transporter family; Region: EamA; pfam00892 714359007638 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359007639 EamA-like transporter family; Region: EamA; pfam00892 714359007640 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359007641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359007642 DNA-binding site [nucleotide binding]; DNA binding site 714359007643 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359007644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359007645 homodimer interface [polypeptide binding]; other site 714359007646 catalytic residue [active] 714359007647 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359007648 Cupin domain; Region: Cupin_2; pfam07883 714359007649 hypothetical protein; Validated; Region: PRK00124 714359007650 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 714359007651 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 714359007652 uridine kinase; Validated; Region: PRK06696 714359007653 AAA domain; Region: AAA_18; pfam13238 714359007654 active site 714359007655 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 714359007656 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359007657 active site 714359007658 metal binding site [ion binding]; metal-binding site 714359007659 Phosphotransferase enzyme family; Region: APH; pfam01636 714359007660 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 714359007661 active site 714359007662 ATP binding site [chemical binding]; other site 714359007663 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 714359007664 active site 714359007665 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359007666 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359007667 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359007668 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359007669 Coenzyme A binding pocket [chemical binding]; other site 714359007670 lysine transporter; Provisional; Region: PRK10836 714359007671 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 714359007672 Methyltransferase domain; Region: Methyltransf_11; pfam08241 714359007673 S-adenosylmethionine binding site [chemical binding]; other site 714359007674 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 714359007675 Cephalosporin hydroxylase; Region: CmcI; pfam04989 714359007676 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714359007677 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359007678 Catalytic site [active] 714359007679 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 714359007680 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359007681 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359007682 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359007683 NAD-dependent deacetylase; Provisional; Region: PRK00481 714359007684 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 714359007685 NAD+ binding site [chemical binding]; other site 714359007686 substrate binding site [chemical binding]; other site 714359007687 Zn binding site [ion binding]; other site 714359007688 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 714359007689 putative substrate binding pocket [chemical binding]; other site 714359007690 AC domain interface; other site 714359007691 catalytic triad [active] 714359007692 AB domain interface; other site 714359007693 interchain disulfide; other site 714359007694 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 714359007695 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714359007696 Predicted membrane protein [Function unknown]; Region: COG3817 714359007697 Protein of unknown function (DUF979); Region: DUF979; pfam06166 714359007698 Protein of unknown function (DUF969); Region: DUF969; pfam06149 714359007699 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 714359007700 putative active site [active] 714359007701 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 714359007702 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 714359007703 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 714359007704 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714359007705 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359007706 Catalytic site [active] 714359007707 CutC family; Region: CutC; cl01218 714359007708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359007709 dimerization interface [polypeptide binding]; other site 714359007710 putative DNA binding site [nucleotide binding]; other site 714359007711 putative Zn2+ binding site [ion binding]; other site 714359007712 DinB superfamily; Region: DinB_2; pfam12867 714359007713 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 714359007714 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 714359007715 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 714359007716 Uncharacterized conserved protein [Function unknown]; Region: COG1434 714359007717 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714359007718 putative active site [active] 714359007719 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359007720 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359007721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 714359007722 Nucleoside recognition; Region: Gate; pfam07670 714359007723 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 714359007724 Phosphotransferase enzyme family; Region: APH; pfam01636 714359007725 putative active site [active] 714359007726 putative substrate binding site [chemical binding]; other site 714359007727 ATP binding site [chemical binding]; other site 714359007728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007729 Coenzyme A binding pocket [chemical binding]; other site 714359007730 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 714359007731 Uncharacterized conserved protein [Function unknown]; Region: COG1633 714359007732 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 714359007733 dinuclear metal binding motif [ion binding]; other site 714359007734 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359007735 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359007736 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 714359007737 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 714359007738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359007739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359007740 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 714359007741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 714359007742 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 714359007743 phosphoenolpyruvate synthase; Validated; Region: PRK06241 714359007744 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 714359007745 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 714359007746 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359007747 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 714359007748 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 714359007749 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359007750 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 714359007751 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714359007752 NAD binding site [chemical binding]; other site 714359007753 catalytic Zn binding site [ion binding]; other site 714359007754 structural Zn binding site [ion binding]; other site 714359007755 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 714359007756 dimanganese center [ion binding]; other site 714359007757 aspartate ammonia-lyase; Provisional; Region: PRK14515 714359007758 Aspartase; Region: Aspartase; cd01357 714359007759 active sites [active] 714359007760 tetramer interface [polypeptide binding]; other site 714359007761 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 714359007762 active site 714359007763 homodimer interface [polypeptide binding]; other site 714359007764 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 714359007765 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 714359007766 Spore germination protein; Region: Spore_permease; pfam03845 714359007767 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359007768 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 714359007769 PAS domain S-box; Region: sensory_box; TIGR00229 714359007770 PAS domain S-box; Region: sensory_box; TIGR00229 714359007771 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359007772 putative active site [active] 714359007773 heme pocket [chemical binding]; other site 714359007774 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 714359007775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359007776 putative active site [active] 714359007777 heme pocket [chemical binding]; other site 714359007778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359007779 dimer interface [polypeptide binding]; other site 714359007780 phosphorylation site [posttranslational modification] 714359007781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359007782 ATP binding site [chemical binding]; other site 714359007783 Mg2+ binding site [ion binding]; other site 714359007784 G-X-G motif; other site 714359007785 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359007786 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359007787 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359007788 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359007789 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 714359007790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359007791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359007792 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359007793 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 714359007794 GIY-YIG motif/motif A; other site 714359007795 active site 714359007796 catalytic site [active] 714359007797 putative DNA binding site [nucleotide binding]; other site 714359007798 metal binding site [ion binding]; metal-binding site 714359007799 amino acid transporter; Region: 2A0306; TIGR00909 714359007800 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 714359007801 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 714359007802 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 714359007803 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 714359007804 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 714359007805 Spore germination protein; Region: Spore_permease; pfam03845 714359007806 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359007807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359007808 Response regulator receiver domain; Region: Response_reg; pfam00072 714359007809 active site 714359007810 phosphorylation site [posttranslational modification] 714359007811 intermolecular recognition site; other site 714359007812 dimerization interface [polypeptide binding]; other site 714359007813 YcbB domain; Region: YcbB; pfam08664 714359007814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359007815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359007816 ATP binding site [chemical binding]; other site 714359007817 Mg2+ binding site [ion binding]; other site 714359007818 G-X-G motif; other site 714359007819 glutaminase; Reviewed; Region: PRK12357 714359007820 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 714359007821 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 714359007822 amino acid carrier protein; Region: agcS; TIGR00835 714359007823 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 714359007824 transmembrane helices; other site 714359007825 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 714359007826 active site 714359007827 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359007828 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359007829 Erythromycin esterase; Region: Erythro_esteras; pfam05139 714359007830 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714359007831 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 714359007832 putative active site [active] 714359007833 putative metal binding site [ion binding]; other site 714359007834 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714359007835 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 714359007836 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 714359007837 TAP-like protein; Region: Abhydrolase_4; pfam08386 714359007838 Isochorismatase family; Region: Isochorismatase; pfam00857 714359007839 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 714359007840 catalytic triad [active] 714359007841 dimer interface [polypeptide binding]; other site 714359007842 conserved cis-peptide bond; other site 714359007843 Isochorismatase family; Region: Isochorismatase; pfam00857 714359007844 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 714359007845 catalytic triad [active] 714359007846 dimer interface [polypeptide binding]; other site 714359007847 conserved cis-peptide bond; other site 714359007848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 714359007849 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 714359007850 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 714359007851 active site 714359007852 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359007853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359007854 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359007855 dimerization interface [polypeptide binding]; other site 714359007856 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 714359007857 Cl binding site [ion binding]; other site 714359007858 oligomer interface [polypeptide binding]; other site 714359007859 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 714359007860 plasmid segregation protein ParM; Provisional; Region: PRK13917 714359007861 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 714359007862 Mg binding site [ion binding]; other site 714359007863 nucleotide binding site [chemical binding]; other site 714359007864 putative protofilament interface [polypeptide binding]; other site 714359007865 Heat induced stress protein YflT; Region: YflT; pfam11181 714359007866 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359007867 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 714359007868 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 714359007869 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 714359007870 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 714359007871 DNA photolyase; Region: DNA_photolyase; pfam00875 714359007872 Adenoviral protein L1 52/55-kDa; Region: Adeno_52K; pfam03052 714359007873 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 714359007874 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 714359007875 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 714359007876 Carbonic anhydrase; Region: Pro_CA; pfam00484 714359007877 zinc binding site [ion binding]; other site 714359007878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 714359007879 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 714359007880 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 714359007881 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 714359007882 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 714359007883 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 714359007884 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 714359007885 NodB motif; other site 714359007886 active site 714359007887 catalytic site [active] 714359007888 Zn binding site [ion binding]; other site 714359007889 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 714359007890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007891 Coenzyme A binding pocket [chemical binding]; other site 714359007892 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 714359007893 UbiA prenyltransferase family; Region: UbiA; pfam01040 714359007894 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 714359007895 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 714359007896 active site 714359007897 ATP binding site [chemical binding]; other site 714359007898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 714359007899 Methyltransferase domain; Region: Methyltransf_23; pfam13489 714359007900 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 714359007901 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 714359007902 Low molecular weight phosphatase family; Region: LMWPc; cd00115 714359007903 active site 714359007904 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 714359007905 arsenical-resistance protein; Region: acr3; TIGR00832 714359007906 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359007907 putative DNA binding site [nucleotide binding]; other site 714359007908 DinB superfamily; Region: DinB_2; pfam12867 714359007909 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 714359007910 RibD C-terminal domain; Region: RibD_C; cl17279 714359007911 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 714359007912 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 714359007913 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 714359007914 putative NAD(P) binding site [chemical binding]; other site 714359007915 active site 714359007916 putative substrate binding site [chemical binding]; other site 714359007917 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359007918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359007919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359007920 short chain dehydrogenase; Provisional; Region: PRK12746 714359007921 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 714359007922 NADP binding site [chemical binding]; other site 714359007923 homodimer interface [polypeptide binding]; other site 714359007924 active site 714359007925 substrate binding site [chemical binding]; other site 714359007926 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 714359007927 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 714359007928 metal binding site [ion binding]; metal-binding site 714359007929 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 714359007930 putative active site [active] 714359007931 catalytic site [active] 714359007932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714359007933 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714359007934 Probable transposase; Region: OrfB_IS605; pfam01385 714359007935 AAA domain; Region: AAA_11; pfam13086 714359007936 Part of AAA domain; Region: AAA_19; pfam13245 714359007937 Erp protein C-terminus; Region: Erp_C; pfam06780 714359007938 AAA domain; Region: AAA_30; pfam13604 714359007939 AAA domain; Region: AAA_12; pfam13087 714359007940 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359007941 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 714359007942 active site 714359007943 metal binding site [ion binding]; metal-binding site 714359007944 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 714359007945 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 714359007946 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714359007947 putative active site [active] 714359007948 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 714359007949 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359007950 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359007951 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359007952 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359007953 putative monooxygenase; Provisional; Region: PRK11118 714359007954 Transcriptional regulators [Transcription]; Region: MarR; COG1846 714359007955 MarR family; Region: MarR_2; pfam12802 714359007956 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 714359007957 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 714359007958 CAAX protease self-immunity; Region: Abi; pfam02517 714359007959 Erythromycin esterase; Region: Erythro_esteras; pfam05139 714359007960 Putative sensor; Region: Sensor; pfam13796 714359007961 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 714359007962 Histidine kinase; Region: HisKA_3; pfam07730 714359007963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359007964 ATP binding site [chemical binding]; other site 714359007965 Mg2+ binding site [ion binding]; other site 714359007966 G-X-G motif; other site 714359007967 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359007968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359007969 active site 714359007970 phosphorylation site [posttranslational modification] 714359007971 intermolecular recognition site; other site 714359007972 dimerization interface [polypeptide binding]; other site 714359007973 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359007974 DNA binding residues [nucleotide binding] 714359007975 dimerization interface [polypeptide binding]; other site 714359007976 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 714359007977 putative metal binding site [ion binding]; other site 714359007978 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 714359007979 Cytochrome P450; Region: p450; pfam00067 714359007980 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 714359007981 Flavodoxin; Region: Flavodoxin_1; pfam00258 714359007982 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 714359007983 FAD binding pocket [chemical binding]; other site 714359007984 FAD binding motif [chemical binding]; other site 714359007985 catalytic residues [active] 714359007986 NAD binding pocket [chemical binding]; other site 714359007987 phosphate binding motif [ion binding]; other site 714359007988 beta-alpha-beta structure motif; other site 714359007989 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359007990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007991 putative substrate translocation pore; other site 714359007992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007993 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 714359007994 D-cysteine desulfhydrase; Validated; Region: PRK03910 714359007995 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 714359007996 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359007997 catalytic residue [active] 714359007998 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 714359007999 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359008000 active site 714359008001 metal binding site [ion binding]; metal-binding site 714359008002 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 714359008003 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359008004 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359008005 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 714359008006 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 714359008007 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 714359008008 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 714359008009 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359008010 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714359008011 Walker A/P-loop; other site 714359008012 ATP binding site [chemical binding]; other site 714359008013 Q-loop/lid; other site 714359008014 ABC transporter signature motif; other site 714359008015 Walker B; other site 714359008016 D-loop; other site 714359008017 H-loop/switch region; other site 714359008018 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 714359008019 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 714359008020 FtsX-like permease family; Region: FtsX; pfam02687 714359008021 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359008022 dimerization interface [polypeptide binding]; other site 714359008023 putative DNA binding site [nucleotide binding]; other site 714359008024 Predicted transcriptional regulator [Transcription]; Region: COG2345 714359008025 putative Zn2+ binding site [ion binding]; other site 714359008026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359008027 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359008028 putative substrate translocation pore; other site 714359008029 DinB superfamily; Region: DinB_2; pfam12867 714359008030 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 714359008031 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359008032 dimerization interface [polypeptide binding]; other site 714359008033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359008034 dimer interface [polypeptide binding]; other site 714359008035 phosphorylation site [posttranslational modification] 714359008036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359008037 ATP binding site [chemical binding]; other site 714359008038 Mg2+ binding site [ion binding]; other site 714359008039 G-X-G motif; other site 714359008040 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359008041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359008042 active site 714359008043 phosphorylation site [posttranslational modification] 714359008044 intermolecular recognition site; other site 714359008045 dimerization interface [polypeptide binding]; other site 714359008046 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359008047 DNA binding site [nucleotide binding] 714359008048 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359008049 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359008050 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 714359008051 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 714359008052 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 714359008053 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 714359008054 Uncharacterized conserved protein [Function unknown]; Region: COG4198 714359008055 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 714359008056 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 714359008057 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 714359008058 putative ligand binding site [chemical binding]; other site 714359008059 putative NAD binding site [chemical binding]; other site 714359008060 putative catalytic site [active] 714359008061 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 714359008062 L-serine binding site [chemical binding]; other site 714359008063 ACT domain interface; other site 714359008064 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 714359008065 homodimer interface [polypeptide binding]; other site 714359008066 substrate-cofactor binding pocket; other site 714359008067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359008068 catalytic residue [active] 714359008069 Uncharacterized conserved protein [Function unknown]; Region: COG2155 714359008070 Cupin domain; Region: Cupin_2; cl17218 714359008071 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 714359008072 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359008073 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 714359008074 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 714359008075 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 714359008076 active site 714359008077 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 714359008078 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 714359008079 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 714359008080 substrate binding site [chemical binding]; other site 714359008081 amidase catalytic site [active] 714359008082 Zn binding residues [ion binding]; other site 714359008083 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359008084 S-layer homology domain; Region: SLH; pfam00395 714359008085 S-layer homology domain; Region: SLH; pfam00395 714359008086 S-layer homology domain; Region: SLH; pfam00395 714359008087 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 714359008088 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 714359008089 Protein of unknown function, DUF600; Region: DUF600; cl04640 714359008090 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 714359008091 A new structural DNA glycosylase; Region: AlkD_like; cd06561 714359008092 active site 714359008093 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 714359008094 Protein of unknown function, DUF600; Region: DUF600; pfam04634 714359008095 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 714359008096 Annexin; Region: Annexin; cl02574 714359008097 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 714359008098 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 714359008099 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 714359008100 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 714359008101 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 714359008102 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 714359008103 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 714359008104 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 714359008105 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 714359008106 Protein of unknown function, DUF600; Region: DUF600; pfam04634 714359008107 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 714359008108 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 714359008109 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 714359008110 A short region before toxin nuclease domain; Region: NUC_N; pfam14448 714359008111 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 714359008112 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 714359008113 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 714359008114 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 714359008115 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 714359008116 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 714359008117 putative active site [active] 714359008118 putative metal binding site [ion binding]; other site 714359008119 NETI protein; Region: NETI; pfam14044 714359008120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359008121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359008122 putative substrate translocation pore; other site 714359008123 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 714359008124 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 714359008125 TAP-like protein; Region: Abhydrolase_4; pfam08386 714359008126 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359008127 MarR family; Region: MarR_2; pfam12802 714359008128 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359008129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359008130 putative substrate translocation pore; other site 714359008131 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359008132 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359008133 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 714359008134 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359008135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359008136 Walker A/P-loop; other site 714359008137 ATP binding site [chemical binding]; other site 714359008138 Q-loop/lid; other site 714359008139 ABC transporter signature motif; other site 714359008140 Walker B; other site 714359008141 D-loop; other site 714359008142 H-loop/switch region; other site 714359008143 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359008144 putative DNA binding site [nucleotide binding]; other site 714359008145 putative Zn2+ binding site [ion binding]; other site 714359008146 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 714359008147 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 714359008148 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 714359008149 SWIM zinc finger; Region: SWIM; pfam04434 714359008150 YwiC-like protein; Region: YwiC; pfam14256 714359008151 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 714359008152 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714359008153 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 714359008154 Walker A/P-loop; other site 714359008155 ATP binding site [chemical binding]; other site 714359008156 Q-loop/lid; other site 714359008157 ABC transporter signature motif; other site 714359008158 Walker B; other site 714359008159 D-loop; other site 714359008160 H-loop/switch region; other site 714359008161 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714359008162 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 714359008163 Walker A/P-loop; other site 714359008164 ATP binding site [chemical binding]; other site 714359008165 Q-loop/lid; other site 714359008166 ABC transporter signature motif; other site 714359008167 Walker B; other site 714359008168 D-loop; other site 714359008169 H-loop/switch region; other site 714359008170 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 714359008171 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 714359008172 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 714359008173 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 714359008174 Predicted membrane protein [Function unknown]; Region: COG1288 714359008175 Endonuclease I; Region: Endonuclease_1; pfam04231 714359008176 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 714359008177 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 714359008178 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359008179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359008180 non-specific DNA binding site [nucleotide binding]; other site 714359008181 salt bridge; other site 714359008182 sequence-specific DNA binding site [nucleotide binding]; other site 714359008183 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 714359008184 putative deacylase active site [active] 714359008185 histidyl-tRNA synthetase; Provisional; Region: PRK12420 714359008186 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 714359008187 dimer interface [polypeptide binding]; other site 714359008188 motif 1; other site 714359008189 active site 714359008190 motif 2; other site 714359008191 motif 3; other site 714359008192 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 714359008193 anticodon binding site; other site 714359008194 Predicted transcriptional regulators [Transcription]; Region: COG1733 714359008195 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 714359008196 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 714359008197 dimer interface [polypeptide binding]; other site 714359008198 FMN binding site [chemical binding]; other site 714359008199 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 714359008200 active site 714359008201 domain interfaces; other site 714359008202 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 714359008203 classical (c) SDRs; Region: SDR_c; cd05233 714359008204 NAD(P) binding site [chemical binding]; other site 714359008205 active site 714359008206 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714359008207 ABC transporter; Region: ABC_tran; pfam00005 714359008208 Q-loop/lid; other site 714359008209 ABC transporter signature motif; other site 714359008210 Walker B; other site 714359008211 D-loop; other site 714359008212 H-loop/switch region; other site 714359008213 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 714359008214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359008215 non-specific DNA binding site [nucleotide binding]; other site 714359008216 salt bridge; other site 714359008217 sequence-specific DNA binding site [nucleotide binding]; other site 714359008218 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 714359008219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359008220 motif II; other site 714359008221 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 714359008222 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 714359008223 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 714359008224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359008225 Coenzyme A binding pocket [chemical binding]; other site 714359008226 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 714359008227 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 714359008228 nudix motif; other site 714359008229 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 714359008230 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 714359008231 active site 714359008232 HIGH motif; other site 714359008233 dimer interface [polypeptide binding]; other site 714359008234 KMSKS motif; other site 714359008235 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 714359008236 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 714359008237 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 714359008238 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 714359008239 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 714359008240 Domain of unknown function DUF20; Region: UPF0118; pfam01594 714359008241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359008242 Coenzyme A binding pocket [chemical binding]; other site 714359008243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359008244 TPR motif; other site 714359008245 TPR repeat; Region: TPR_11; pfam13414 714359008246 binding surface 714359008247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359008248 binding surface 714359008249 Tetratricopeptide repeat; Region: TPR_16; pfam13432 714359008250 TPR motif; other site 714359008251 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 714359008252 hypothetical protein; Provisional; Region: PRK04164 714359008253 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 714359008254 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 714359008255 Domain of unknown function DUF21; Region: DUF21; pfam01595 714359008256 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714359008257 Transporter associated domain; Region: CorC_HlyC; smart01091 714359008258 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 714359008259 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 714359008260 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 714359008261 substrate binding site; other site 714359008262 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 714359008263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359008264 NAD(P) binding site [chemical binding]; other site 714359008265 active site 714359008266 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 714359008267 Methyltransferase domain; Region: Methyltransf_23; pfam13489 714359008268 Methyltransferase domain; Region: Methyltransf_12; pfam08242 714359008269 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 714359008270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359008271 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 714359008272 NAD(P) binding site [chemical binding]; other site 714359008273 active site 714359008274 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 714359008275 Src Homology 3 domain superfamily; Region: SH3; cl17036 714359008276 peptide ligand binding site [polypeptide binding]; other site 714359008277 EamA-like transporter family; Region: EamA; pfam00892 714359008278 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359008279 EamA-like transporter family; Region: EamA; pfam00892 714359008280 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 714359008281 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 714359008282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 714359008283 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 714359008284 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 714359008285 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 714359008286 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 714359008287 N- and C-terminal domain interface [polypeptide binding]; other site 714359008288 active site 714359008289 catalytic site [active] 714359008290 metal binding site [ion binding]; metal-binding site 714359008291 carbohydrate binding site [chemical binding]; other site 714359008292 ATP binding site [chemical binding]; other site 714359008293 GntP family permease; Region: GntP_permease; pfam02447 714359008294 fructuronate transporter; Provisional; Region: PRK10034; cl15264 714359008295 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 714359008296 active site 714359008297 intersubunit interactions; other site 714359008298 catalytic residue [active] 714359008299 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 714359008300 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 714359008301 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 714359008302 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 714359008303 TPP-binding site [chemical binding]; other site 714359008304 dimer interface [polypeptide binding]; other site 714359008305 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 714359008306 PYR/PP interface [polypeptide binding]; other site 714359008307 dimer interface [polypeptide binding]; other site 714359008308 TPP binding site [chemical binding]; other site 714359008309 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714359008310 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 714359008311 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 714359008312 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 714359008313 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 714359008314 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714359008315 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 714359008316 putative NAD(P) binding site [chemical binding]; other site 714359008317 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 714359008318 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 714359008319 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 714359008320 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714359008321 putative NAD(P) binding site [chemical binding]; other site 714359008322 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 714359008323 classical (c) SDRs; Region: SDR_c; cd05233 714359008324 NAD(P) binding site [chemical binding]; other site 714359008325 active site 714359008326 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359008327 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359008328 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 714359008329 active site 714359008330 Zn binding site [ion binding]; other site 714359008331 Viral enhancin protein; Region: Enhancin; pfam03272 714359008332 Peptidase M60-like family; Region: M60-like; pfam13402 714359008333 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 714359008334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359008335 dimerization interface [polypeptide binding]; other site 714359008336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359008337 dimer interface [polypeptide binding]; other site 714359008338 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 714359008339 putative CheW interface [polypeptide binding]; other site 714359008340 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 714359008341 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 714359008342 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 714359008343 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 714359008344 catalytic motif [active] 714359008345 Zn binding site [ion binding]; other site 714359008346 RibD C-terminal domain; Region: RibD_C; cl17279 714359008347 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 714359008348 dimerization interface [polypeptide binding]; other site 714359008349 active site 714359008350 Predicted transcriptional regulators [Transcription]; Region: COG1733 714359008351 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 714359008352 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 714359008353 dimer interface [polypeptide binding]; other site 714359008354 FMN binding site [chemical binding]; other site 714359008355 BNR repeat-like domain; Region: BNR_2; pfam13088 714359008356 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359008357 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714359008358 active site 714359008359 catalytic tetrad [active] 714359008360 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 714359008361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359008362 putative substrate translocation pore; other site 714359008363 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 714359008364 active site 1 [active] 714359008365 dimer interface [polypeptide binding]; other site 714359008366 hexamer interface [polypeptide binding]; other site 714359008367 active site 2 [active] 714359008368 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 714359008369 hexamer interface [polypeptide binding]; other site 714359008370 active site 2 [active] 714359008371 hypothetical protein; Provisional; Region: PRK02487 714359008372 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 714359008373 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 714359008374 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 714359008375 IDEAL domain; Region: IDEAL; pfam08858 714359008376 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 714359008377 Predicted transcriptional regulators [Transcription]; Region: COG1733 714359008378 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359008379 dimerization interface [polypeptide binding]; other site 714359008380 putative DNA binding site [nucleotide binding]; other site 714359008381 putative Zn2+ binding site [ion binding]; other site 714359008382 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714359008383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359008384 DNA-binding site [nucleotide binding]; DNA binding site 714359008385 UTRA domain; Region: UTRA; pfam07702 714359008386 putative oxidoreductase; Provisional; Region: PRK10206 714359008387 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 714359008388 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 714359008389 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 714359008390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 714359008391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359008392 S-adenosylmethionine binding site [chemical binding]; other site 714359008393 Predicted transcriptional regulators [Transcription]; Region: COG1733 714359008394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359008395 dimerization interface [polypeptide binding]; other site 714359008396 putative DNA binding site [nucleotide binding]; other site 714359008397 putative Zn2+ binding site [ion binding]; other site 714359008398 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714359008399 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359008400 active site 714359008401 catalytic tetrad [active] 714359008402 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 714359008403 putative hydrophobic ligand binding site [chemical binding]; other site 714359008404 protein interface [polypeptide binding]; other site 714359008405 gate; other site 714359008406 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 714359008407 catalytic triad [active] 714359008408 oxyanion hole [active] 714359008409 active site 714359008410 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359008411 Phosphotransferase enzyme family; Region: APH; pfam01636 714359008412 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 714359008413 active site 714359008414 substrate binding site [chemical binding]; other site 714359008415 ATP binding site [chemical binding]; other site 714359008416 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 714359008417 Uncharacterized conserved protein [Function unknown]; Region: COG0327 714359008418 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 714359008419 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 714359008420 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 714359008421 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 714359008422 acyl-activating enzyme (AAE) consensus motif; other site 714359008423 AMP binding site [chemical binding]; other site 714359008424 active site 714359008425 CoA binding site [chemical binding]; other site 714359008426 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 714359008427 Predicted transcriptional regulators [Transcription]; Region: COG1733 714359008428 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359008429 dimerization interface [polypeptide binding]; other site 714359008430 putative DNA binding site [nucleotide binding]; other site 714359008431 putative Zn2+ binding site [ion binding]; other site 714359008432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359008433 dimerization interface [polypeptide binding]; other site 714359008434 putative DNA binding site [nucleotide binding]; other site 714359008435 putative Zn2+ binding site [ion binding]; other site 714359008436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714359008437 Helix-turn-helix domain; Region: HTH_28; pfam13518 714359008438 Helix-turn-helix domain; Region: HTH_28; pfam13518 714359008439 putative transposase OrfB; Reviewed; Region: PHA02517 714359008440 HTH-like domain; Region: HTH_21; pfam13276 714359008441 Integrase core domain; Region: rve; pfam00665 714359008442 Integrase core domain; Region: rve_2; pfam13333 714359008443 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 714359008444 active site 714359008445 Glyco_18 domain; Region: Glyco_18; smart00636 714359008446 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 714359008447 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 714359008448 NodB motif; other site 714359008449 putative active site [active] 714359008450 putative catalytic site [active] 714359008451 putative Zn binding site [ion binding]; other site 714359008452 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 714359008453 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 714359008454 DXD motif; other site 714359008455 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 714359008456 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 714359008457 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359008458 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359008459 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 714359008460 active site 714359008461 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 714359008462 VPS10 domain; Region: VPS10; smart00602 714359008463 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 714359008464 HTH domain; Region: HTH_11; pfam08279 714359008465 WYL domain; Region: WYL; pfam13280 714359008466 ABC-2 type transporter; Region: ABC2_membrane; cl17235 714359008467 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 714359008468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359008469 Walker A/P-loop; other site 714359008470 ATP binding site [chemical binding]; other site 714359008471 Q-loop/lid; other site 714359008472 ABC transporter signature motif; other site 714359008473 Walker B; other site 714359008474 D-loop; other site 714359008475 H-loop/switch region; other site 714359008476 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 714359008477 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 714359008478 hydroxylamine reductase; Provisional; Region: PRK12310 714359008479 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714359008480 ACS interaction site; other site 714359008481 CODH interaction site; other site 714359008482 metal cluster binding site [ion binding]; other site 714359008483 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359008484 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 714359008485 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 714359008486 active site 714359008487 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 714359008488 metal binding site [ion binding]; metal-binding site 714359008489 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 714359008490 hypothetical protein; Provisional; Region: PRK06771 714359008491 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 714359008492 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 714359008493 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 714359008494 dimer interface [polypeptide binding]; other site 714359008495 ligand binding site [chemical binding]; other site 714359008496 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 714359008497 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714359008498 ligand binding site [chemical binding]; other site 714359008499 flexible hinge region; other site 714359008500 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 714359008501 Protein of unknown function, DUF606; Region: DUF606; pfam04657 714359008502 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359008503 putative transport protein YifK; Provisional; Region: PRK10746 714359008504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359008505 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 714359008506 putative substrate translocation pore; other site 714359008507 Haemolysin XhlA; Region: XhlA; pfam10779 714359008508 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 714359008509 classical (c) SDRs; Region: SDR_c; cd05233 714359008510 NAD(P) binding site [chemical binding]; other site 714359008511 active site 714359008512 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 714359008513 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 714359008514 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 714359008515 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 714359008516 transmembrane helices; other site 714359008517 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359008518 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359008519 Coenzyme A binding pocket [chemical binding]; other site 714359008520 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 714359008521 putative ligand binding residues [chemical binding]; other site 714359008522 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 714359008523 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 714359008524 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359008525 ABC-ATPase subunit interface; other site 714359008526 dimer interface [polypeptide binding]; other site 714359008527 putative PBP binding regions; other site 714359008528 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714359008529 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359008530 ABC-ATPase subunit interface; other site 714359008531 dimer interface [polypeptide binding]; other site 714359008532 putative PBP binding regions; other site 714359008533 Protein of unknown function (DUF817); Region: DUF817; pfam05675 714359008534 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 714359008535 DinB superfamily; Region: DinB_2; pfam12867 714359008536 DinB family; Region: DinB; cl17821 714359008537 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 714359008538 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 714359008539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359008540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359008541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359008542 dimerization interface [polypeptide binding]; other site 714359008543 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714359008544 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 714359008545 NADP binding site [chemical binding]; other site 714359008546 dimer interface [polypeptide binding]; other site 714359008547 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359008548 catalytic core [active] 714359008549 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359008550 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359008551 Coenzyme A binding pocket [chemical binding]; other site 714359008552 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 714359008553 MutS domain III; Region: MutS_III; pfam05192 714359008554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359008555 Walker A/P-loop; other site 714359008556 ATP binding site [chemical binding]; other site 714359008557 Q-loop/lid; other site 714359008558 ABC transporter signature motif; other site 714359008559 Walker B; other site 714359008560 D-loop; other site 714359008561 H-loop/switch region; other site 714359008562 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 714359008563 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 714359008564 active site 714359008565 Na/Ca binding site [ion binding]; other site 714359008566 catalytic site [active] 714359008567 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 714359008568 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 714359008569 oligoendopeptidase F; Region: pepF; TIGR00181 714359008570 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 714359008571 active site 714359008572 Zn binding site [ion binding]; other site 714359008573 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359008574 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359008575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359008576 putative substrate translocation pore; other site 714359008577 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359008578 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359008579 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359008580 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 714359008581 putative dimerization interface [polypeptide binding]; other site 714359008582 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 714359008583 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 714359008584 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 714359008585 active site 714359008586 catalytic site [active] 714359008587 metal binding site [ion binding]; metal-binding site 714359008588 FAD binding domain; Region: FAD_binding_3; pfam01494 714359008589 hypothetical protein; Provisional; Region: PRK07236 714359008590 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 714359008591 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359008592 dimerization interface [polypeptide binding]; other site 714359008593 putative DNA binding site [nucleotide binding]; other site 714359008594 putative Zn2+ binding site [ion binding]; other site 714359008595 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714359008596 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 714359008597 putative NAD(P) binding site [chemical binding]; other site 714359008598 Uncharacterized conserved protein [Function unknown]; Region: COG0397 714359008599 hypothetical protein; Validated; Region: PRK00029 714359008600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359008601 TPR motif; other site 714359008602 binding surface 714359008603 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 714359008604 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 714359008605 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 714359008606 FAD binding domain; Region: FAD_binding_4; pfam01565 714359008607 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 714359008608 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359008609 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359008610 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 714359008611 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 714359008612 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 714359008613 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 714359008614 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714359008615 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714359008616 active site residue [active] 714359008617 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 714359008618 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714359008619 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 714359008620 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 714359008621 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359008622 active site 714359008623 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359008624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359008625 NAD(P) binding site [chemical binding]; other site 714359008626 active site 714359008627 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 714359008628 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 714359008629 NAD binding site [chemical binding]; other site 714359008630 homotetramer interface [polypeptide binding]; other site 714359008631 homodimer interface [polypeptide binding]; other site 714359008632 substrate binding site [chemical binding]; other site 714359008633 active site 714359008634 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359008635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359008636 TPR motif; other site 714359008637 binding surface 714359008638 Tar ligand binding domain homologue; Region: TarH; pfam02203 714359008639 Cache domain; Region: Cache_1; pfam02743 714359008640 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359008641 dimerization interface [polypeptide binding]; other site 714359008642 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359008643 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359008644 dimer interface [polypeptide binding]; other site 714359008645 putative CheW interface [polypeptide binding]; other site 714359008646 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 714359008647 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 714359008648 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359008649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359008650 TPR motif; other site 714359008651 binding surface 714359008652 PAS domain S-box; Region: sensory_box; TIGR00229 714359008653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359008654 putative active site [active] 714359008655 heme pocket [chemical binding]; other site 714359008656 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714359008657 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359008658 metal binding site [ion binding]; metal-binding site 714359008659 active site 714359008660 I-site; other site 714359008661 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359008662 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359008663 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359008664 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359008665 TQXA domain; Region: TQXA_dom; TIGR03934 714359008666 Cna protein B-type domain; Region: Cna_B; pfam05738 714359008667 Cna protein B-type domain; Region: Cna_B; pfam05738 714359008668 Cna protein B-type domain; Region: Cna_B; pfam05738 714359008669 Cna protein B-type domain; Region: Cna_B; pfam05738 714359008670 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 714359008671 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 714359008672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359008673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359008674 dimer interface [polypeptide binding]; other site 714359008675 phosphorylation site [posttranslational modification] 714359008676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359008677 ATP binding site [chemical binding]; other site 714359008678 Mg2+ binding site [ion binding]; other site 714359008679 G-X-G motif; other site 714359008680 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 714359008681 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 714359008682 FOG: PKD repeat [General function prediction only]; Region: COG3291 714359008683 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 714359008684 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 714359008685 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 714359008686 MgtC family; Region: MgtC; pfam02308 714359008687 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359008688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359008689 Coenzyme A binding pocket [chemical binding]; other site 714359008690 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 714359008691 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 714359008692 putative metal binding site [ion binding]; other site 714359008693 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359008694 active site 714359008695 VanW like protein; Region: VanW; pfam04294 714359008696 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 714359008697 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 714359008698 exonuclease; Provisional; Region: PRK06722 714359008699 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 714359008700 active site 714359008701 catalytic site [active] 714359008702 substrate binding site [chemical binding]; other site 714359008703 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714359008704 DNA-binding site [nucleotide binding]; DNA binding site 714359008705 RNA-binding motif; other site 714359008706 flavodoxin; Provisional; Region: PRK06703 714359008707 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 714359008708 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 714359008709 nudix motif; other site 714359008710 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 714359008711 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 714359008712 trimer interface [polypeptide binding]; other site 714359008713 active site 714359008714 substrate binding site [chemical binding]; other site 714359008715 CoA binding site [chemical binding]; other site 714359008716 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008717 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008718 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008719 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008720 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008721 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008722 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008723 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008724 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008725 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008726 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008727 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008728 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008729 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359008730 short chain dehydrogenase; Provisional; Region: PRK06924 714359008731 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 714359008732 NADP binding site [chemical binding]; other site 714359008733 homodimer interface [polypeptide binding]; other site 714359008734 active site 714359008735 Predicted acetyltransferase [General function prediction only]; Region: COG3393 714359008736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359008737 Coenzyme A binding pocket [chemical binding]; other site 714359008738 argininosuccinate lyase; Provisional; Region: PRK06705 714359008739 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 714359008740 active sites [active] 714359008741 tetramer interface [polypeptide binding]; other site 714359008742 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714359008743 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714359008744 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 714359008745 active site 714359008746 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 714359008747 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 714359008748 Na binding site [ion binding]; other site 714359008749 Protein of unknown function (DUF997); Region: DUF997; pfam06196 714359008750 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 714359008751 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 714359008752 NAD(P) binding site [chemical binding]; other site 714359008753 catalytic residues [active] 714359008754 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 714359008755 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 714359008756 NAD(P) binding site [chemical binding]; other site 714359008757 homotetramer interface [polypeptide binding]; other site 714359008758 homodimer interface [polypeptide binding]; other site 714359008759 active site 714359008760 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 714359008761 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 714359008762 Divergent PAP2 family; Region: DUF212; pfam02681 714359008763 Predicted permeases [General function prediction only]; Region: RarD; COG2962 714359008764 EamA-like transporter family; Region: EamA; pfam00892 714359008765 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 714359008766 Domain of unknown function DUF59; Region: DUF59; pfam01883 714359008767 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 714359008768 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 714359008769 Walker A motif; other site 714359008770 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 714359008771 MoaE interaction surface [polypeptide binding]; other site 714359008772 MoeB interaction surface [polypeptide binding]; other site 714359008773 thiocarboxylated glycine; other site 714359008774 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 714359008775 MoaE homodimer interface [polypeptide binding]; other site 714359008776 MoaD interaction [polypeptide binding]; other site 714359008777 active site residues [active] 714359008778 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 714359008779 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 714359008780 dimer interface [polypeptide binding]; other site 714359008781 putative functional site; other site 714359008782 putative MPT binding site; other site 714359008783 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 714359008784 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 714359008785 ATP binding site [chemical binding]; other site 714359008786 substrate interface [chemical binding]; other site 714359008787 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 714359008788 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 714359008789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359008790 FeS/SAM binding site; other site 714359008791 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 714359008792 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 714359008793 Uncharacterized conserved protein [Function unknown]; Region: COG5609 714359008794 Uncharacterized conserved protein [Function unknown]; Region: COG2427 714359008795 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 714359008796 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 714359008797 catalytic loop [active] 714359008798 iron binding site [ion binding]; other site 714359008799 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 714359008800 4Fe-4S binding domain; Region: Fer4; pfam00037 714359008801 4Fe-4S binding domain; Region: Fer4; pfam00037 714359008802 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 714359008803 [4Fe-4S] binding site [ion binding]; other site 714359008804 molybdopterin cofactor binding site; other site 714359008805 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 714359008806 molybdopterin cofactor binding site; other site 714359008807 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359008808 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 714359008809 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 714359008810 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 714359008811 amino acid transporter; Region: 2A0306; TIGR00909 714359008812 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 714359008813 Tubulin like; Region: Tubulin_2; pfam13809 714359008814 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 714359008815 metal ion-dependent adhesion site (MIDAS); other site 714359008816 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359008817 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 714359008818 active site 714359008819 metal binding site [ion binding]; metal-binding site 714359008820 Methyltransferase domain; Region: Methyltransf_31; pfam13847 714359008821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359008822 S-adenosylmethionine binding site [chemical binding]; other site 714359008823 O-methyltransferase; Region: Methyltransf_2; pfam00891 714359008824 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359008825 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359008826 peptide binding site [polypeptide binding]; other site 714359008827 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359008828 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359008829 peptide binding site [polypeptide binding]; other site 714359008830 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359008831 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359008832 peptide binding site [polypeptide binding]; other site 714359008833 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 714359008834 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 714359008835 Transcriptional regulator [Transcription]; Region: LytR; COG1316 714359008836 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 714359008837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359008838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359008839 DNA binding residues [nucleotide binding] 714359008840 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 714359008841 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359008842 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714359008843 Walker A/P-loop; other site 714359008844 ATP binding site [chemical binding]; other site 714359008845 Q-loop/lid; other site 714359008846 ABC transporter signature motif; other site 714359008847 Walker B; other site 714359008848 D-loop; other site 714359008849 H-loop/switch region; other site 714359008850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359008851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359008852 putative oxidoreductase; Provisional; Region: PRK11579 714359008853 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 714359008854 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 714359008855 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 714359008856 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 714359008857 CAP-like domain; other site 714359008858 active site 714359008859 primary dimer interface [polypeptide binding]; other site 714359008860 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359008861 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359008862 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359008863 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359008864 TopoisomeraseII; Region: TOP2c; smart00433 714359008865 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 714359008866 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 714359008867 anchoring element; other site 714359008868 dimer interface [polypeptide binding]; other site 714359008869 ATP binding site [chemical binding]; other site 714359008870 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 714359008871 active site 714359008872 putative metal-binding site [ion binding]; other site 714359008873 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 714359008874 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 714359008875 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 714359008876 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 714359008877 protein binding site [polypeptide binding]; other site 714359008878 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359008879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359008880 active site 714359008881 phosphorylation site [posttranslational modification] 714359008882 intermolecular recognition site; other site 714359008883 dimerization interface [polypeptide binding]; other site 714359008884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359008885 DNA binding site [nucleotide binding] 714359008886 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 714359008887 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359008888 FeS/SAM binding site; other site 714359008889 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 714359008890 Class III ribonucleotide reductase; Region: RNR_III; cd01675 714359008891 effector binding site; other site 714359008892 active site 714359008893 Zn binding site [ion binding]; other site 714359008894 glycine loop; other site 714359008895 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 714359008896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 714359008897 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 714359008898 active site 714359008899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714359008900 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714359008901 Probable transposase; Region: OrfB_IS605; pfam01385 714359008902 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714359008903 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 714359008904 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714359008905 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714359008906 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 714359008907 active site 714359008908 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 714359008909 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 714359008910 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 714359008911 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 714359008912 active site 714359008913 catalytic site [active] 714359008914 substrate binding site [chemical binding]; other site 714359008915 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 714359008916 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 714359008917 catalytic residues [active] 714359008918 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714359008919 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359008920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359008921 Walker A/P-loop; other site 714359008922 ATP binding site [chemical binding]; other site 714359008923 Q-loop/lid; other site 714359008924 ABC transporter signature motif; other site 714359008925 Walker B; other site 714359008926 D-loop; other site 714359008927 H-loop/switch region; other site 714359008928 aconitate hydratase; Validated; Region: PRK09277 714359008929 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 714359008930 substrate binding site [chemical binding]; other site 714359008931 ligand binding site [chemical binding]; other site 714359008932 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 714359008933 substrate binding site [chemical binding]; other site 714359008934 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 714359008935 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 714359008936 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 714359008937 NodB motif; other site 714359008938 active site 714359008939 catalytic site [active] 714359008940 metal binding site [ion binding]; metal-binding site 714359008941 Small acid-soluble spore protein P family; Region: SspP; cl12105 714359008942 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 714359008943 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 714359008944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359008945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359008946 putative substrate translocation pore; other site 714359008947 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 714359008948 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 714359008949 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 714359008950 nudix motif; other site 714359008951 SAP domain; Region: SAP; cl02640 714359008952 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 714359008953 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 714359008954 dimer interface [polypeptide binding]; other site 714359008955 active site 714359008956 acyl-CoA synthetase; Validated; Region: PRK07638 714359008957 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 714359008958 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 714359008959 acyl-activating enzyme (AAE) consensus motif; other site 714359008960 acyl-activating enzyme (AAE) consensus motif; other site 714359008961 AMP binding site [chemical binding]; other site 714359008962 active site 714359008963 CoA binding site [chemical binding]; other site 714359008964 BioY family; Region: BioY; pfam02632 714359008965 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 714359008966 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 714359008967 dimer interface [polypeptide binding]; other site 714359008968 acyl-activating enzyme (AAE) consensus motif; other site 714359008969 putative active site [active] 714359008970 AMP binding site [chemical binding]; other site 714359008971 putative CoA binding site [chemical binding]; other site 714359008972 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359008973 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359008974 non-specific DNA binding site [nucleotide binding]; other site 714359008975 salt bridge; other site 714359008976 sequence-specific DNA binding site [nucleotide binding]; other site 714359008977 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359008978 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359008979 Coenzyme A binding pocket [chemical binding]; other site 714359008980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359008981 Coenzyme A binding pocket [chemical binding]; other site 714359008982 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 714359008983 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 714359008984 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359008985 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359008986 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 714359008987 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359008988 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 714359008989 dimer interface [polypeptide binding]; other site 714359008990 putative metal binding site [ion binding]; other site 714359008991 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359008992 PAS domain; Region: PAS_9; pfam13426 714359008993 putative active site [active] 714359008994 heme pocket [chemical binding]; other site 714359008995 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 714359008996 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359008997 putative active site [active] 714359008998 heme pocket [chemical binding]; other site 714359008999 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359009000 dimer interface [polypeptide binding]; other site 714359009001 phosphorylation site [posttranslational modification] 714359009002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359009003 ATP binding site [chemical binding]; other site 714359009004 Mg2+ binding site [ion binding]; other site 714359009005 G-X-G motif; other site 714359009006 Predicted esterase [General function prediction only]; Region: COG0400 714359009007 putative hydrolase; Provisional; Region: PRK11460 714359009008 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 714359009009 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359009010 Zn binding site [ion binding]; other site 714359009011 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 714359009012 Zn binding site [ion binding]; other site 714359009013 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 714359009014 Na binding site [ion binding]; other site 714359009015 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 714359009016 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 714359009017 active site 714359009018 FMN binding site [chemical binding]; other site 714359009019 substrate binding site [chemical binding]; other site 714359009020 3Fe-4S cluster binding site [ion binding]; other site 714359009021 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 714359009022 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 714359009023 FMN binding site [chemical binding]; other site 714359009024 active site 714359009025 substrate binding site [chemical binding]; other site 714359009026 catalytic residue [active] 714359009027 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 714359009028 agmatinase; Region: agmatinase; TIGR01230 714359009029 Agmatinase-like family; Region: Agmatinase-like; cd09990 714359009030 active site 714359009031 oligomer interface [polypeptide binding]; other site 714359009032 Mn binding site [ion binding]; other site 714359009033 imidazolonepropionase; Region: hutI; TIGR01224 714359009034 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 714359009035 active site 714359009036 urocanate hydratase; Provisional; Region: PRK05414 714359009037 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 714359009038 tetramer interface [polypeptide binding]; other site 714359009039 active sites [active] 714359009040 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cl07944 714359009041 hexamer interface [polypeptide binding]; other site 714359009042 Histidine-zinc binding site [chemical binding]; other site 714359009043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359009044 S-adenosylmethionine binding site [chemical binding]; other site 714359009045 DJ-1 family protein; Region: not_thiJ; TIGR01383 714359009046 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 714359009047 conserved cys residue [active] 714359009048 AAA domain; Region: AAA_28; pfam13521 714359009049 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 714359009050 active site 714359009051 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 714359009052 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 714359009053 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 714359009054 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 714359009055 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359009056 EamA-like transporter family; Region: EamA; pfam00892 714359009057 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 714359009058 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 714359009059 metal binding site [ion binding]; metal-binding site 714359009060 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 714359009061 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 714359009062 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359009063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359009064 Walker A/P-loop; other site 714359009065 ATP binding site [chemical binding]; other site 714359009066 Q-loop/lid; other site 714359009067 ABC transporter signature motif; other site 714359009068 Walker B; other site 714359009069 D-loop; other site 714359009070 H-loop/switch region; other site 714359009071 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 714359009072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359009073 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 714359009074 putative dimerization interface [polypeptide binding]; other site 714359009075 putative substrate binding pocket [chemical binding]; other site 714359009076 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 714359009077 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 714359009078 nudix motif; other site 714359009079 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 714359009080 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359009081 Nuclease-related domain; Region: NERD; pfam08378 714359009082 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 714359009083 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 714359009084 active site 714359009085 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359009086 Bacterial SH3 domain; Region: SH3_3; cl17532 714359009087 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714359009088 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359009089 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 714359009090 Walker A/P-loop; other site 714359009091 ATP binding site [chemical binding]; other site 714359009092 Q-loop/lid; other site 714359009093 ABC transporter signature motif; other site 714359009094 Walker B; other site 714359009095 D-loop; other site 714359009096 H-loop/switch region; other site 714359009097 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359009098 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 714359009099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359009100 Walker A/P-loop; other site 714359009101 ATP binding site [chemical binding]; other site 714359009102 Q-loop/lid; other site 714359009103 ABC transporter signature motif; other site 714359009104 Walker B; other site 714359009105 D-loop; other site 714359009106 H-loop/switch region; other site 714359009107 hypothetical protein; Provisional; Region: PRK01844 714359009108 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 714359009109 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 714359009110 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 714359009111 TPP-binding site [chemical binding]; other site 714359009112 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 714359009113 PYR/PP interface [polypeptide binding]; other site 714359009114 dimer interface [polypeptide binding]; other site 714359009115 TPP binding site [chemical binding]; other site 714359009116 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714359009117 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 714359009118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359009119 dimer interface [polypeptide binding]; other site 714359009120 conserved gate region; other site 714359009121 ABC-ATPase subunit interface; other site 714359009122 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 714359009123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359009124 dimer interface [polypeptide binding]; other site 714359009125 conserved gate region; other site 714359009126 ABC-ATPase subunit interface; other site 714359009127 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 714359009128 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 714359009129 Q-loop/lid; other site 714359009130 ABC transporter signature motif; other site 714359009131 Walker B; other site 714359009132 D-loop; other site 714359009133 H-loop/switch region; other site 714359009134 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 714359009135 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359009136 membrane-bound complex binding site; other site 714359009137 hinge residues; other site 714359009138 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714359009139 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 714359009140 active site 714359009141 metal binding site [ion binding]; metal-binding site 714359009142 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714359009143 hypothetical protein; Provisional; Region: PRK01546 714359009144 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 714359009145 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 714359009146 catalytic residues [active] 714359009147 catalytic nucleophile [active] 714359009148 LexA repressor; Validated; Region: PRK00215 714359009149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359009150 putative DNA binding site [nucleotide binding]; other site 714359009151 putative Zn2+ binding site [ion binding]; other site 714359009152 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 714359009153 Catalytic site [active] 714359009154 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 714359009155 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 714359009156 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 714359009157 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 714359009158 Predicted transcriptional regulators [Transcription]; Region: COG1695 714359009159 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 714359009160 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 714359009161 amidase catalytic site [active] 714359009162 Zn binding residues [ion binding]; other site 714359009163 substrate binding site [chemical binding]; other site 714359009164 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359009165 Haemolysin XhlA; Region: XhlA; pfam10779 714359009166 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 714359009167 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359009168 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 714359009169 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714359009170 catalytic residue [active] 714359009171 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 714359009172 Helix-turn-helix domain; Region: HTH_36; pfam13730 714359009173 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 714359009174 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 714359009175 ORF6C domain; Region: ORF6C; pfam10552 714359009176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359009177 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 714359009178 non-specific DNA binding site [nucleotide binding]; other site 714359009179 salt bridge; other site 714359009180 sequence-specific DNA binding site [nucleotide binding]; other site 714359009181 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 714359009182 Catalytic site [active] 714359009183 glutamine synthetase, type I; Region: GlnA; TIGR00653 714359009184 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 714359009185 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 714359009186 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 714359009187 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 714359009188 DNA binding residues [nucleotide binding] 714359009189 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 714359009190 Aluminium resistance protein; Region: Alum_res; pfam06838 714359009191 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 714359009192 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 714359009193 HflX GTPase family; Region: HflX; cd01878 714359009194 G1 box; other site 714359009195 GTP/Mg2+ binding site [chemical binding]; other site 714359009196 Switch I region; other site 714359009197 G2 box; other site 714359009198 G3 box; other site 714359009199 Switch II region; other site 714359009200 G4 box; other site 714359009201 G5 box; other site 714359009202 Predicted membrane protein [Function unknown]; Region: COG2860 714359009203 UPF0126 domain; Region: UPF0126; pfam03458 714359009204 UPF0126 domain; Region: UPF0126; pfam03458 714359009205 stage V sporulation protein K; Region: spore_V_K; TIGR02881 714359009206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359009207 Walker A motif; other site 714359009208 ATP binding site [chemical binding]; other site 714359009209 Walker B motif; other site 714359009210 arginine finger; other site 714359009211 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 714359009212 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 714359009213 active site 714359009214 catalytic residues [active] 714359009215 DNA binding site [nucleotide binding] 714359009216 Int/Topo IB signature motif; other site 714359009217 bacterial Hfq-like; Region: Hfq; cd01716 714359009218 hexamer interface [polypeptide binding]; other site 714359009219 Sm1 motif; other site 714359009220 RNA binding site [nucleotide binding]; other site 714359009221 Sm2 motif; other site 714359009222 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 714359009223 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 714359009224 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359009225 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359009226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 714359009227 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 714359009228 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714359009229 active site 714359009230 phosphorylation site [posttranslational modification] 714359009231 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 714359009232 active site 714359009233 P-loop; other site 714359009234 phosphorylation site [posttranslational modification] 714359009235 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 714359009236 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 714359009237 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 714359009238 putative substrate binding site [chemical binding]; other site 714359009239 putative ATP binding site [chemical binding]; other site 714359009240 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714359009241 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 714359009242 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714359009243 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 714359009244 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 714359009245 dimer interface [polypeptide binding]; other site 714359009246 active site 714359009247 metal binding site [ion binding]; metal-binding site 714359009248 Predicted membrane protein [Function unknown]; Region: COG2322 714359009249 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 714359009250 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 714359009251 Glyco_18 domain; Region: Glyco_18; smart00636 714359009252 putative active site [active] 714359009253 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 714359009254 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359009255 putative active site [active] 714359009256 putative metal binding site [ion binding]; other site 714359009257 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 714359009258 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 714359009259 IHF dimer interface [polypeptide binding]; other site 714359009260 IHF - DNA interface [nucleotide binding]; other site 714359009261 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 714359009262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359009263 Coenzyme A binding pocket [chemical binding]; other site 714359009264 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 714359009265 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359009266 metal-binding site [ion binding] 714359009267 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 714359009268 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359009269 metal-binding site [ion binding] 714359009270 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359009271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359009272 motif II; other site 714359009273 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 714359009274 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359009275 metal-binding site [ion binding] 714359009276 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 714359009277 putative homodimer interface [polypeptide binding]; other site 714359009278 putative homotetramer interface [polypeptide binding]; other site 714359009279 allosteric switch controlling residues; other site 714359009280 putative metal binding site [ion binding]; other site 714359009281 putative homodimer-homodimer interface [polypeptide binding]; other site 714359009282 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 714359009283 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714359009284 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714359009285 Walker A/P-loop; other site 714359009286 ATP binding site [chemical binding]; other site 714359009287 Q-loop/lid; other site 714359009288 ABC transporter signature motif; other site 714359009289 Walker B; other site 714359009290 D-loop; other site 714359009291 H-loop/switch region; other site 714359009292 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714359009293 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359009294 ABC-ATPase subunit interface; other site 714359009295 dimer interface [polypeptide binding]; other site 714359009296 putative PBP binding regions; other site 714359009297 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714359009298 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359009299 ABC-ATPase subunit interface; other site 714359009300 dimer interface [polypeptide binding]; other site 714359009301 putative PBP binding regions; other site 714359009302 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 714359009303 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 714359009304 putative ligand binding residues [chemical binding]; other site 714359009305 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 714359009306 active site 714359009307 putative catalytic site [active] 714359009308 DNA binding site [nucleotide binding] 714359009309 putative phosphate binding site [ion binding]; other site 714359009310 metal binding site A [ion binding]; metal-binding site 714359009311 AP binding site [nucleotide binding]; other site 714359009312 metal binding site B [ion binding]; metal-binding site 714359009313 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 714359009314 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 714359009315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359009316 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359009317 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 714359009318 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 714359009319 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 714359009320 DNA binding site [nucleotide binding] 714359009321 active site 714359009322 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 714359009323 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 714359009324 endonuclease III; Region: ENDO3c; smart00478 714359009325 minor groove reading motif; other site 714359009326 helix-hairpin-helix signature motif; other site 714359009327 substrate binding pocket [chemical binding]; other site 714359009328 active site 714359009329 peptidase T; Region: peptidase-T; TIGR01882 714359009330 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 714359009331 metal binding site [ion binding]; metal-binding site 714359009332 dimer interface [polypeptide binding]; other site 714359009333 hypothetical protein; Provisional; Region: PRK06764 714359009334 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359009335 catalytic core [active] 714359009336 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 714359009337 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 714359009338 PAS domain S-box; Region: sensory_box; TIGR00229 714359009339 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359009340 putative active site [active] 714359009341 heme pocket [chemical binding]; other site 714359009342 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714359009343 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359009344 metal binding site [ion binding]; metal-binding site 714359009345 active site 714359009346 I-site; other site 714359009347 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359009348 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 714359009349 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 714359009350 active site 714359009351 homodimer interface [polypeptide binding]; other site 714359009352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009353 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 714359009354 NAD(P) binding site [chemical binding]; other site 714359009355 active site 714359009356 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 714359009357 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 714359009358 NAD(P) binding site [chemical binding]; other site 714359009359 homodimer interface [polypeptide binding]; other site 714359009360 substrate binding site [chemical binding]; other site 714359009361 active site 714359009362 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 714359009363 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 714359009364 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 714359009365 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359009366 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359009367 DNA-binding site [nucleotide binding]; DNA binding site 714359009368 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359009369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359009370 homodimer interface [polypeptide binding]; other site 714359009371 catalytic residue [active] 714359009372 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714359009373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359009374 DNA-binding site [nucleotide binding]; DNA binding site 714359009375 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 714359009376 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 714359009377 beta-galactosidase; Region: BGL; TIGR03356 714359009378 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 714359009379 active site 714359009380 catalytic site [active] 714359009381 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 714359009382 putative active site [active] 714359009383 putative catalytic triad [active] 714359009384 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 714359009385 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714359009386 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 714359009387 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714359009388 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 714359009389 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 714359009390 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 714359009391 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 714359009392 Sulfatase; Region: Sulfatase; pfam00884 714359009393 Tetratricopeptide repeat; Region: TPR_16; pfam13432 714359009394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359009395 binding surface 714359009396 TPR motif; other site 714359009397 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 714359009398 G1 box; other site 714359009399 GTP/Mg2+ binding site [chemical binding]; other site 714359009400 Switch I region; other site 714359009401 G3 box; other site 714359009402 Switch II region; other site 714359009403 G4 box; other site 714359009404 G5 box; other site 714359009405 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 714359009406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359009407 ATP binding site [chemical binding]; other site 714359009408 Mg2+ binding site [ion binding]; other site 714359009409 G-X-G motif; other site 714359009410 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 714359009411 ATP binding site [chemical binding]; other site 714359009412 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 714359009413 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 714359009414 MutS domain I; Region: MutS_I; pfam01624 714359009415 MutS domain II; Region: MutS_II; pfam05188 714359009416 MutS domain III; Region: MutS_III; pfam05192 714359009417 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 714359009418 Walker A/P-loop; other site 714359009419 ATP binding site [chemical binding]; other site 714359009420 Q-loop/lid; other site 714359009421 ABC transporter signature motif; other site 714359009422 Walker B; other site 714359009423 D-loop; other site 714359009424 H-loop/switch region; other site 714359009425 Outer spore coat protein E (CotE); Region: CotE; pfam10628 714359009426 Predicted membrane protein [Function unknown]; Region: COG4550 714359009427 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 714359009428 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 714359009429 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359009430 FeS/SAM binding site; other site 714359009431 TRAM domain; Region: TRAM; pfam01938 714359009432 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 714359009433 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 714359009434 TPP-binding site [chemical binding]; other site 714359009435 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 714359009436 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 714359009437 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 714359009438 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 714359009439 dimer interface [polypeptide binding]; other site 714359009440 PYR/PP interface [polypeptide binding]; other site 714359009441 TPP binding site [chemical binding]; other site 714359009442 substrate binding site [chemical binding]; other site 714359009443 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714359009444 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 714359009445 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 714359009446 active site 714359009447 dimer interface [polypeptide binding]; other site 714359009448 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 714359009449 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 714359009450 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359009451 putative active site [active] 714359009452 metal binding site [ion binding]; metal-binding site 714359009453 homodimer binding site [polypeptide binding]; other site 714359009454 phosphodiesterase; Provisional; Region: PRK12704 714359009455 Uncharacterized conserved protein [Function unknown]; Region: COG3334 714359009456 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359009457 Zn2+ binding site [ion binding]; other site 714359009458 Mg2+ binding site [ion binding]; other site 714359009459 recombinase A; Provisional; Region: recA; PRK09354 714359009460 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 714359009461 hexamer interface [polypeptide binding]; other site 714359009462 Walker A motif; other site 714359009463 ATP binding site [chemical binding]; other site 714359009464 Walker B motif; other site 714359009465 competence damage-inducible protein A; Provisional; Region: PRK00549 714359009466 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 714359009467 putative MPT binding site; other site 714359009468 Competence-damaged protein; Region: CinA; pfam02464 714359009469 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 714359009470 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 714359009471 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359009472 non-specific DNA binding site [nucleotide binding]; other site 714359009473 salt bridge; other site 714359009474 sequence-specific DNA binding site [nucleotide binding]; other site 714359009475 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 714359009476 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 714359009477 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 714359009478 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 714359009479 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 714359009480 classical (c) SDRs; Region: SDR_c; cd05233 714359009481 NAD(P) binding site [chemical binding]; other site 714359009482 active site 714359009483 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 714359009484 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 714359009485 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 714359009486 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 714359009487 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 714359009488 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714359009489 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 714359009490 TM-ABC transporter signature motif; other site 714359009491 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714359009492 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 714359009493 TM-ABC transporter signature motif; other site 714359009494 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 714359009495 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 714359009496 Walker A/P-loop; other site 714359009497 ATP binding site [chemical binding]; other site 714359009498 Q-loop/lid; other site 714359009499 ABC transporter signature motif; other site 714359009500 Walker B; other site 714359009501 D-loop; other site 714359009502 H-loop/switch region; other site 714359009503 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 714359009504 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 714359009505 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 714359009506 ligand binding site [chemical binding]; other site 714359009507 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714359009508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359009509 DNA-binding site [nucleotide binding]; DNA binding site 714359009510 UTRA domain; Region: UTRA; pfam07702 714359009511 Tetraspanin family; Region: Tetraspannin; pfam00335 714359009512 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 714359009513 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 714359009514 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 714359009515 Clp protease; Region: CLP_protease; pfam00574 714359009516 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 714359009517 active site 714359009518 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 714359009519 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359009520 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 714359009521 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 714359009522 dihydrodipicolinate synthase; Region: dapA; TIGR00674 714359009523 dimer interface [polypeptide binding]; other site 714359009524 active site 714359009525 catalytic residue [active] 714359009526 aspartate kinase I; Reviewed; Region: PRK08210 714359009527 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 714359009528 nucleotide binding site [chemical binding]; other site 714359009529 substrate binding site [chemical binding]; other site 714359009530 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 714359009531 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 714359009532 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 714359009533 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 714359009534 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 714359009535 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 714359009536 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 714359009537 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 714359009538 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 714359009539 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 714359009540 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 714359009541 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 714359009542 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 714359009543 NodB motif; other site 714359009544 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 714359009545 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 714359009546 RNase E interface [polypeptide binding]; other site 714359009547 trimer interface [polypeptide binding]; other site 714359009548 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 714359009549 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 714359009550 RNase E interface [polypeptide binding]; other site 714359009551 trimer interface [polypeptide binding]; other site 714359009552 active site 714359009553 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 714359009554 putative nucleic acid binding region [nucleotide binding]; other site 714359009555 G-X-X-G motif; other site 714359009556 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 714359009557 RNA binding site [nucleotide binding]; other site 714359009558 domain interface; other site 714359009559 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 714359009560 16S/18S rRNA binding site [nucleotide binding]; other site 714359009561 S13e-L30e interaction site [polypeptide binding]; other site 714359009562 25S rRNA binding site [nucleotide binding]; other site 714359009563 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 714359009564 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 714359009565 active site 714359009566 Riboflavin kinase; Region: Flavokinase; pfam01687 714359009567 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 714359009568 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 714359009569 RNA binding site [nucleotide binding]; other site 714359009570 active site 714359009571 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 714359009572 Protein of unknown function (DUF503); Region: DUF503; pfam04456 714359009573 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 714359009574 translation initiation factor IF-2; Region: IF-2; TIGR00487 714359009575 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 714359009576 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 714359009577 G1 box; other site 714359009578 putative GEF interaction site [polypeptide binding]; other site 714359009579 GTP/Mg2+ binding site [chemical binding]; other site 714359009580 Switch I region; other site 714359009581 G2 box; other site 714359009582 G3 box; other site 714359009583 Switch II region; other site 714359009584 G4 box; other site 714359009585 G5 box; other site 714359009586 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 714359009587 Translation-initiation factor 2; Region: IF-2; pfam11987 714359009588 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 714359009589 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 714359009590 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 714359009591 putative RNA binding cleft [nucleotide binding]; other site 714359009592 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 714359009593 NusA N-terminal domain; Region: NusA_N; pfam08529 714359009594 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 714359009595 RNA binding site [nucleotide binding]; other site 714359009596 homodimer interface [polypeptide binding]; other site 714359009597 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 714359009598 G-X-X-G motif; other site 714359009599 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 714359009600 G-X-X-G motif; other site 714359009601 ribosome maturation protein RimP; Reviewed; Region: PRK00092 714359009602 Sm and related proteins; Region: Sm_like; cl00259 714359009603 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 714359009604 putative oligomer interface [polypeptide binding]; other site 714359009605 putative RNA binding site [nucleotide binding]; other site 714359009606 DNA polymerase III PolC; Validated; Region: polC; PRK00448 714359009607 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 714359009608 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 714359009609 generic binding surface II; other site 714359009610 generic binding surface I; other site 714359009611 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 714359009612 active site 714359009613 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 714359009614 active site 714359009615 catalytic site [active] 714359009616 substrate binding site [chemical binding]; other site 714359009617 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 714359009618 prolyl-tRNA synthetase; Provisional; Region: PRK09194 714359009619 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 714359009620 dimer interface [polypeptide binding]; other site 714359009621 motif 1; other site 714359009622 active site 714359009623 motif 2; other site 714359009624 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 714359009625 putative deacylase active site [active] 714359009626 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 714359009627 active site 714359009628 motif 3; other site 714359009629 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 714359009630 anticodon binding site; other site 714359009631 RIP metalloprotease RseP; Region: TIGR00054 714359009632 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 714359009633 active site 714359009634 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 714359009635 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 714359009636 protein binding site [polypeptide binding]; other site 714359009637 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 714359009638 putative substrate binding region [chemical binding]; other site 714359009639 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 714359009640 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 714359009641 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 714359009642 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 714359009643 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 714359009644 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 714359009645 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 714359009646 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 714359009647 catalytic residue [active] 714359009648 putative FPP diphosphate binding site; other site 714359009649 putative FPP binding hydrophobic cleft; other site 714359009650 dimer interface [polypeptide binding]; other site 714359009651 putative IPP diphosphate binding site; other site 714359009652 ribosome recycling factor; Reviewed; Region: frr; PRK00083 714359009653 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 714359009654 hinge region; other site 714359009655 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 714359009656 putative nucleotide binding site [chemical binding]; other site 714359009657 uridine monophosphate binding site [chemical binding]; other site 714359009658 homohexameric interface [polypeptide binding]; other site 714359009659 elongation factor Ts; Provisional; Region: tsf; PRK09377 714359009660 UBA/TS-N domain; Region: UBA; pfam00627 714359009661 Elongation factor TS; Region: EF_TS; pfam00889 714359009662 Elongation factor TS; Region: EF_TS; pfam00889 714359009663 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 714359009664 rRNA interaction site [nucleotide binding]; other site 714359009665 S8 interaction site; other site 714359009666 putative laminin-1 binding site; other site 714359009667 transcriptional repressor CodY; Validated; Region: PRK04158 714359009668 CodY GAF-like domain; Region: CodY; pfam06018 714359009669 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 714359009670 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 714359009671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359009672 Walker A motif; other site 714359009673 ATP binding site [chemical binding]; other site 714359009674 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 714359009675 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 714359009676 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 714359009677 HslU subunit interaction site [polypeptide binding]; other site 714359009678 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 714359009679 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 714359009680 active site 714359009681 Int/Topo IB signature motif; other site 714359009682 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 714359009683 Glucose inhibited division protein A; Region: GIDA; pfam01134 714359009684 DNA topoisomerase I; Validated; Region: PRK05582 714359009685 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 714359009686 active site 714359009687 metal binding site [ion binding]; metal-binding site 714359009688 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 714359009689 domain I; other site 714359009690 DNA binding groove [nucleotide binding] 714359009691 phosphate binding site [ion binding]; other site 714359009692 domain II; other site 714359009693 domain III; other site 714359009694 nucleotide binding site [chemical binding]; other site 714359009695 catalytic site [active] 714359009696 domain IV; other site 714359009697 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 714359009698 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 714359009699 DNA protecting protein DprA; Region: dprA; TIGR00732 714359009700 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 714359009701 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 714359009702 CoA binding domain; Region: CoA_binding; smart00881 714359009703 CoA-ligase; Region: Ligase_CoA; pfam00549 714359009704 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 714359009705 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 714359009706 CoA-ligase; Region: Ligase_CoA; pfam00549 714359009707 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 714359009708 RNA/DNA hybrid binding site [nucleotide binding]; other site 714359009709 active site 714359009710 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 714359009711 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 714359009712 GTP/Mg2+ binding site [chemical binding]; other site 714359009713 G4 box; other site 714359009714 G5 box; other site 714359009715 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 714359009716 G1 box; other site 714359009717 G1 box; other site 714359009718 GTP/Mg2+ binding site [chemical binding]; other site 714359009719 Switch I region; other site 714359009720 G2 box; other site 714359009721 G2 box; other site 714359009722 G3 box; other site 714359009723 G3 box; other site 714359009724 Switch II region; other site 714359009725 Switch II region; other site 714359009726 G4 box; other site 714359009727 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714359009728 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359009729 Catalytic site [active] 714359009730 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 714359009731 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 714359009732 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 714359009733 RimM N-terminal domain; Region: RimM; pfam01782 714359009734 PRC-barrel domain; Region: PRC; pfam05239 714359009735 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 714359009736 KH domain; Region: KH_4; pfam13083 714359009737 G-X-X-G motif; other site 714359009738 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 714359009739 signal recognition particle protein; Provisional; Region: PRK10867 714359009740 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 714359009741 GTP binding site [chemical binding]; other site 714359009742 Signal peptide binding domain; Region: SRP_SPB; pfam02978 714359009743 putative DNA-binding protein; Validated; Region: PRK00118 714359009744 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 714359009745 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 714359009746 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 714359009747 P loop; other site 714359009748 GTP binding site [chemical binding]; other site 714359009749 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 714359009750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359009751 Q-loop/lid; other site 714359009752 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 714359009753 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 714359009754 ABC transporter signature motif; other site 714359009755 Walker B; other site 714359009756 D-loop; other site 714359009757 H-loop/switch region; other site 714359009758 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 714359009759 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 714359009760 dimerization interface [polypeptide binding]; other site 714359009761 active site 714359009762 metal binding site [ion binding]; metal-binding site 714359009763 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 714359009764 dsRNA binding site [nucleotide binding]; other site 714359009765 acyl carrier protein; Provisional; Region: acpP; PRK00982 714359009766 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 714359009767 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 714359009768 NAD(P) binding site [chemical binding]; other site 714359009769 homotetramer interface [polypeptide binding]; other site 714359009770 homodimer interface [polypeptide binding]; other site 714359009771 active site 714359009772 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 714359009773 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 714359009774 putative phosphate acyltransferase; Provisional; Region: PRK05331 714359009775 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 714359009776 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 714359009777 active site 2 [active] 714359009778 active site 1 [active] 714359009779 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 714359009780 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 714359009781 generic binding surface II; other site 714359009782 ssDNA binding site; other site 714359009783 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359009784 ATP binding site [chemical binding]; other site 714359009785 putative Mg++ binding site [ion binding]; other site 714359009786 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359009787 nucleotide binding region [chemical binding]; other site 714359009788 ATP-binding site [chemical binding]; other site 714359009789 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 714359009790 DAK2 domain; Region: Dak2; pfam02734 714359009791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 714359009792 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 714359009793 Thiamine pyrophosphokinase; Region: TPK; cd07995 714359009794 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 714359009795 active site 714359009796 dimerization interface [polypeptide binding]; other site 714359009797 thiamine binding site [chemical binding]; other site 714359009798 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 714359009799 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 714359009800 substrate binding site [chemical binding]; other site 714359009801 hexamer interface [polypeptide binding]; other site 714359009802 metal binding site [ion binding]; metal-binding site 714359009803 GTPase RsgA; Reviewed; Region: PRK00098 714359009804 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 714359009805 RNA binding site [nucleotide binding]; other site 714359009806 homodimer interface [polypeptide binding]; other site 714359009807 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 714359009808 GTPase/Zn-binding domain interface [polypeptide binding]; other site 714359009809 GTP/Mg2+ binding site [chemical binding]; other site 714359009810 G4 box; other site 714359009811 G5 box; other site 714359009812 G1 box; other site 714359009813 Switch I region; other site 714359009814 G2 box; other site 714359009815 G3 box; other site 714359009816 Switch II region; other site 714359009817 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 714359009818 Catalytic domain of Protein Kinases; Region: PKc; cd00180 714359009819 active site 714359009820 ATP binding site [chemical binding]; other site 714359009821 substrate binding site [chemical binding]; other site 714359009822 activation loop (A-loop); other site 714359009823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 714359009824 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 714359009825 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 714359009826 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 714359009827 Protein phosphatase 2C; Region: PP2C; pfam00481 714359009828 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 714359009829 active site 714359009830 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 714359009831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359009832 FeS/SAM binding site; other site 714359009833 16S rRNA methyltransferase B; Provisional; Region: PRK14902 714359009834 NusB family; Region: NusB; pfam01029 714359009835 putative RNA binding site [nucleotide binding]; other site 714359009836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359009837 S-adenosylmethionine binding site [chemical binding]; other site 714359009838 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 714359009839 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 714359009840 putative active site [active] 714359009841 substrate binding site [chemical binding]; other site 714359009842 putative cosubstrate binding site; other site 714359009843 catalytic site [active] 714359009844 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 714359009845 substrate binding site [chemical binding]; other site 714359009846 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 714359009847 active site 714359009848 catalytic residues [active] 714359009849 metal binding site [ion binding]; metal-binding site 714359009850 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 714359009851 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359009852 ATP binding site [chemical binding]; other site 714359009853 putative Mg++ binding site [ion binding]; other site 714359009854 helicase superfamily c-terminal domain; Region: HELICc; smart00490 714359009855 nucleotide binding region [chemical binding]; other site 714359009856 ATP-binding site [chemical binding]; other site 714359009857 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 714359009858 Flavoprotein; Region: Flavoprotein; pfam02441 714359009859 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 714359009860 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 714359009861 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 714359009862 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 714359009863 catalytic site [active] 714359009864 G-X2-G-X-G-K; other site 714359009865 hypothetical protein; Provisional; Region: PRK04323 714359009866 hypothetical protein; Provisional; Region: PRK11820 714359009867 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 714359009868 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 714359009869 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 714359009870 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 714359009871 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359009872 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 714359009873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359009874 motif II; other site 714359009875 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 714359009876 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 714359009877 Domain of unknown function (DUF814); Region: DUF814; pfam05670 714359009878 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 714359009879 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 714359009880 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 714359009881 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 714359009882 active site 714359009883 Protein of unknown function (DUF664); Region: DUF664; pfam04978 714359009884 DinB superfamily; Region: DinB_2; pfam12867 714359009885 YoqO-like protein; Region: YoqO; pfam14037 714359009886 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 714359009887 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 714359009888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714359009889 active site 714359009890 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 714359009891 active site 714359009892 dimer interface [polypeptide binding]; other site 714359009893 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 714359009894 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 714359009895 heterodimer interface [polypeptide binding]; other site 714359009896 active site 714359009897 FMN binding site [chemical binding]; other site 714359009898 homodimer interface [polypeptide binding]; other site 714359009899 substrate binding site [chemical binding]; other site 714359009900 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 714359009901 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 714359009902 FAD binding pocket [chemical binding]; other site 714359009903 FAD binding motif [chemical binding]; other site 714359009904 phosphate binding motif [ion binding]; other site 714359009905 beta-alpha-beta structure motif; other site 714359009906 NAD binding pocket [chemical binding]; other site 714359009907 Iron coordination center [ion binding]; other site 714359009908 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 714359009909 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714359009910 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 714359009911 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 714359009912 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714359009913 ATP-grasp domain; Region: ATP-grasp_4; cl17255 714359009914 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 714359009915 IMP binding site; other site 714359009916 dimer interface [polypeptide binding]; other site 714359009917 interdomain contacts; other site 714359009918 partial ornithine binding site; other site 714359009919 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 714359009920 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 714359009921 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 714359009922 catalytic site [active] 714359009923 subunit interface [polypeptide binding]; other site 714359009924 dihydroorotase; Validated; Region: pyrC; PRK09357 714359009925 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 714359009926 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 714359009927 active site 714359009928 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 714359009929 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 714359009930 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 714359009931 uracil transporter; Provisional; Region: PRK10720 714359009932 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 714359009933 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714359009934 active site 714359009935 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 714359009936 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359009937 RNA binding surface [nucleotide binding]; other site 714359009938 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 714359009939 active site 714359009940 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 714359009941 lipoprotein signal peptidase; Provisional; Region: PRK14787 714359009942 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 714359009943 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 714359009944 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 714359009945 active site 714359009946 HIGH motif; other site 714359009947 nucleotide binding site [chemical binding]; other site 714359009948 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 714359009949 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 714359009950 active site 714359009951 KMSKS motif; other site 714359009952 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 714359009953 tRNA binding surface [nucleotide binding]; other site 714359009954 anticodon binding site; other site 714359009955 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 714359009956 DivIVA protein; Region: DivIVA; pfam05103 714359009957 DivIVA domain; Region: DivI1A_domain; TIGR03544 714359009958 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 714359009959 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 714359009960 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359009961 RNA binding surface [nucleotide binding]; other site 714359009962 Protein of unknown function (DUF552); Region: DUF552; pfam04472 714359009963 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 714359009964 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714359009965 catalytic residue [active] 714359009966 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 714359009967 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 714359009968 sporulation sigma factor SigG; Reviewed; Region: PRK08215 714359009969 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359009970 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359009971 DNA binding residues [nucleotide binding] 714359009972 sporulation sigma factor SigE; Reviewed; Region: PRK08301 714359009973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359009974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359009975 DNA binding residues [nucleotide binding] 714359009976 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 714359009977 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 714359009978 cell division protein FtsZ; Validated; Region: PRK09330 714359009979 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 714359009980 nucleotide binding site [chemical binding]; other site 714359009981 SulA interaction site; other site 714359009982 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 714359009983 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714359009984 nucleotide binding site [chemical binding]; other site 714359009985 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 714359009986 Cell division protein FtsA; Region: FtsA; pfam14450 714359009987 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 714359009988 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 714359009989 Cell division protein FtsQ; Region: FtsQ; pfam03799 714359009990 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 714359009991 FAD binding domain; Region: FAD_binding_4; pfam01565 714359009992 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 714359009993 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 714359009994 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 714359009995 active site 714359009996 homodimer interface [polypeptide binding]; other site 714359009997 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 714359009998 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 714359009999 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714359010000 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714359010001 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 714359010002 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 714359010003 Mg++ binding site [ion binding]; other site 714359010004 putative catalytic motif [active] 714359010005 putative substrate binding site [chemical binding]; other site 714359010006 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 714359010007 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 714359010008 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714359010009 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714359010010 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 714359010011 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359010012 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359010013 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 714359010014 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 714359010015 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359010016 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359010017 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 714359010018 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 714359010019 Cell division protein FtsL; Region: FtsL; cl11433 714359010020 MraW methylase family; Region: Methyltransf_5; pfam01795 714359010021 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 714359010022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 714359010023 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 714359010024 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 714359010025 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 714359010026 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 714359010027 hypothetical protein; Provisional; Region: PRK13688 714359010028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359010029 Coenzyme A binding pocket [chemical binding]; other site 714359010030 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 714359010031 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 714359010032 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 714359010033 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 714359010034 hypothetical protein; Provisional; Region: PRK13670 714359010035 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 714359010036 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 714359010037 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 714359010038 protein binding site [polypeptide binding]; other site 714359010039 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 714359010040 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 714359010041 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 714359010042 active site 714359010043 nucleophile elbow; other site 714359010044 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 714359010045 Nucleoside recognition; Region: Gate; pfam07670 714359010046 Nucleoside recognition; Region: Gate; pfam07670 714359010047 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 714359010048 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 714359010049 active site 714359010050 (T/H)XGH motif; other site 714359010051 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 714359010052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359010053 S-adenosylmethionine binding site [chemical binding]; other site 714359010054 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 714359010055 Protein of unknown function (DUF964); Region: DUF964; pfam06133 714359010056 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359010057 catalytic core [active] 714359010058 YlbE-like protein; Region: YlbE; pfam14003 714359010059 Putative coat protein; Region: YlbD_coat; pfam14071 714359010060 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 714359010061 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 714359010062 YugN-like family; Region: YugN; pfam08868 714359010063 formamidase; Provisional; Region: amiF; PRK13287 714359010064 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 714359010065 multimer interface [polypeptide binding]; other site 714359010066 active site 714359010067 catalytic triad [active] 714359010068 dimer interface [polypeptide binding]; other site 714359010069 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 714359010070 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 714359010071 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 714359010072 Subunit I/III interface [polypeptide binding]; other site 714359010073 Subunit III/IV interface [polypeptide binding]; other site 714359010074 cytochrome aa3 quinol oxidase, subunit I; Region: QoxB; TIGR02882 714359010075 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 714359010076 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 714359010077 D-pathway; other site 714359010078 Low-spin heme binding site [chemical binding]; other site 714359010079 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 714359010080 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 714359010081 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 714359010082 Cytochrome c; Region: Cytochrom_C; pfam00034 714359010083 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 714359010084 UbiA prenyltransferase family; Region: UbiA; pfam01040 714359010085 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 714359010086 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 714359010087 pyruvate carboxylase; Reviewed; Region: PRK12999 714359010088 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714359010089 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 714359010090 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 714359010091 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 714359010092 active site 714359010093 catalytic residues [active] 714359010094 metal binding site [ion binding]; metal-binding site 714359010095 homodimer binding site [polypeptide binding]; other site 714359010096 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 714359010097 carboxyltransferase (CT) interaction site; other site 714359010098 biotinylation site [posttranslational modification]; other site 714359010099 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 714359010100 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 714359010101 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 714359010102 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 714359010103 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 714359010104 putative active site [active] 714359010105 PhoH-like protein; Region: PhoH; pfam02562 714359010106 hypothetical protein; Provisional; Region: PRK06733 714359010107 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 714359010108 YlaH-like protein; Region: YlaH; pfam14036 714359010109 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 714359010110 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 714359010111 Switch I region; other site 714359010112 G2 box; other site 714359010113 putative GEF interaction site [polypeptide binding]; other site 714359010114 G3 box; other site 714359010115 Switch II region; other site 714359010116 GTP/Mg2+ binding site [chemical binding]; other site 714359010117 G4 box; other site 714359010118 G5 box; other site 714359010119 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 714359010120 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 714359010121 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 714359010122 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 714359010123 active site 714359010124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 714359010125 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 714359010126 hypothetical protein; Provisional; Region: PRK04387 714359010127 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 714359010128 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 714359010129 homodimer interface [polypeptide binding]; other site 714359010130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359010131 catalytic residue [active] 714359010132 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 714359010133 transglutaminase; Provisional; Region: tgl; PRK03187 714359010134 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 714359010135 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 714359010136 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 714359010137 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 714359010138 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 714359010139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714359010140 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714359010141 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 714359010142 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714359010143 E3 interaction surface; other site 714359010144 lipoyl attachment site [posttranslational modification]; other site 714359010145 e3 binding domain; Region: E3_binding; pfam02817 714359010146 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 714359010147 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 714359010148 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 714359010149 alpha subunit interface [polypeptide binding]; other site 714359010150 TPP binding site [chemical binding]; other site 714359010151 heterodimer interface [polypeptide binding]; other site 714359010152 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714359010153 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 714359010154 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 714359010155 TPP-binding site [chemical binding]; other site 714359010156 heterodimer interface [polypeptide binding]; other site 714359010157 tetramer interface [polypeptide binding]; other site 714359010158 phosphorylation loop region [posttranslational modification] 714359010159 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 714359010160 active site 714359010161 catalytic residues [active] 714359010162 metal binding site [ion binding]; metal-binding site 714359010163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359010164 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359010165 active site 714359010166 motif I; other site 714359010167 motif II; other site 714359010168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359010169 hypothetical protein; Provisional; Region: PRK13667 714359010170 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 714359010171 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359010172 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 714359010173 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 714359010174 TrkA-N domain; Region: TrkA_N; pfam02254 714359010175 TrkA-C domain; Region: TrkA_C; pfam02080 714359010176 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 714359010177 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 714359010178 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 714359010179 metal binding site [ion binding]; metal-binding site 714359010180 putative dimer interface [polypeptide binding]; other site 714359010181 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 714359010182 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 714359010183 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 714359010184 trimer interface [polypeptide binding]; other site 714359010185 active site 714359010186 substrate binding site [chemical binding]; other site 714359010187 CoA binding site [chemical binding]; other site 714359010188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359010189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359010190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359010191 dimerization interface [polypeptide binding]; other site 714359010192 FOG: CBS domain [General function prediction only]; Region: COG0517 714359010193 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 714359010194 Protein of unknown function (DUF458); Region: DUF458; pfam04308 714359010195 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 714359010196 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 714359010197 catalytic residues [active] 714359010198 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 714359010199 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359010200 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 714359010201 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 714359010202 short chain dehydrogenase; Provisional; Region: PRK07677 714359010203 NAD(P) binding site [chemical binding]; other site 714359010204 substrate binding site [chemical binding]; other site 714359010205 homotetramer interface [polypeptide binding]; other site 714359010206 active site 714359010207 homodimer interface [polypeptide binding]; other site 714359010208 phosphodiesterase YaeI; Provisional; Region: PRK11340 714359010209 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 714359010210 putative active site [active] 714359010211 putative metal binding site [ion binding]; other site 714359010212 polyphosphate kinase; Provisional; Region: PRK05443 714359010213 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 714359010214 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 714359010215 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 714359010216 putative domain interface [polypeptide binding]; other site 714359010217 putative active site [active] 714359010218 catalytic site [active] 714359010219 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 714359010220 putative domain interface [polypeptide binding]; other site 714359010221 putative active site [active] 714359010222 catalytic site [active] 714359010223 exopolyphosphatase; Region: exo_poly_only; TIGR03706 714359010224 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714359010225 nucleotide binding site [chemical binding]; other site 714359010226 YkyB-like protein; Region: YkyB; pfam14177 714359010227 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 714359010228 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359010229 I-site; other site 714359010230 active site 714359010231 metal binding site [ion binding]; metal-binding site 714359010232 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359010233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359010234 putative substrate translocation pore; other site 714359010235 Predicted transcriptional regulators [Transcription]; Region: COG1695 714359010236 Transcriptional regulator PadR-like family; Region: PadR; cl17335 714359010237 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 714359010238 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 714359010239 THF binding site; other site 714359010240 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 714359010241 substrate binding site [chemical binding]; other site 714359010242 THF binding site; other site 714359010243 zinc-binding site [ion binding]; other site 714359010244 Competence protein J (ComJ); Region: ComJ; pfam11033 714359010245 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 714359010246 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 714359010247 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 714359010248 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359010249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359010250 dimer interface [polypeptide binding]; other site 714359010251 phosphorylation site [posttranslational modification] 714359010252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359010253 ATP binding site [chemical binding]; other site 714359010254 Mg2+ binding site [ion binding]; other site 714359010255 G-X-G motif; other site 714359010256 aminotransferase A; Validated; Region: PRK07683 714359010257 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359010258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359010259 homodimer interface [polypeptide binding]; other site 714359010260 catalytic residue [active] 714359010261 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359010262 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359010263 DNA binding site [nucleotide binding] 714359010264 domain linker motif; other site 714359010265 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 714359010266 putative dimerization interface [polypeptide binding]; other site 714359010267 putative ligand binding site [chemical binding]; other site 714359010268 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 714359010269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359010270 dimer interface [polypeptide binding]; other site 714359010271 conserved gate region; other site 714359010272 putative PBP binding loops; other site 714359010273 ABC-ATPase subunit interface; other site 714359010274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359010275 dimer interface [polypeptide binding]; other site 714359010276 conserved gate region; other site 714359010277 putative PBP binding loops; other site 714359010278 ABC-ATPase subunit interface; other site 714359010279 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 714359010280 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 714359010281 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 714359010282 homodimer interface [polypeptide binding]; other site 714359010283 maltodextrin glucosidase; Provisional; Region: PRK10785 714359010284 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 714359010285 active site 714359010286 homodimer interface [polypeptide binding]; other site 714359010287 catalytic site [active] 714359010288 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 714359010289 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 714359010290 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 714359010291 Ca binding site [ion binding]; other site 714359010292 active site 714359010293 catalytic site [active] 714359010294 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 714359010295 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 714359010296 Walker A/P-loop; other site 714359010297 ATP binding site [chemical binding]; other site 714359010298 Q-loop/lid; other site 714359010299 ABC transporter signature motif; other site 714359010300 Walker B; other site 714359010301 D-loop; other site 714359010302 H-loop/switch region; other site 714359010303 TOBE domain; Region: TOBE_2; pfam08402 714359010304 hypothetical protein; Provisional; Region: PRK06720 714359010305 NAD(P) binding site [chemical binding]; other site 714359010306 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 714359010307 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 714359010308 Predicted ATPase [General function prediction only]; Region: COG3910 714359010309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359010310 Walker A/P-loop; other site 714359010311 ATP binding site [chemical binding]; other site 714359010312 Q-loop/lid; other site 714359010313 ABC transporter signature motif; other site 714359010314 Walker B; other site 714359010315 D-loop; other site 714359010316 H-loop/switch region; other site 714359010317 putative acyltransferase; Provisional; Region: PRK05790 714359010318 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 714359010319 dimer interface [polypeptide binding]; other site 714359010320 active site 714359010321 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 714359010322 nudix motif; other site 714359010323 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 714359010324 hypothetical protein; Validated; Region: PRK07668 714359010325 hypothetical protein; Validated; Region: PRK07668 714359010326 Predicted transcriptional regulators [Transcription]; Region: COG1695 714359010327 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 714359010328 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 714359010329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359010330 NAD(P) binding site [chemical binding]; other site 714359010331 active site 714359010332 YvrJ protein family; Region: YvrJ; pfam12841 714359010333 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 714359010334 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 714359010335 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 714359010336 Phosphotransferase enzyme family; Region: APH; pfam01636 714359010337 Predicted amidohydrolase [General function prediction only]; Region: COG0388 714359010338 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 714359010339 putative active site [active] 714359010340 catalytic triad [active] 714359010341 putative dimer interface [polypeptide binding]; other site 714359010342 transaminase; Reviewed; Region: PRK08068 714359010343 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359010344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359010345 homodimer interface [polypeptide binding]; other site 714359010346 catalytic residue [active] 714359010347 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 714359010348 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 714359010349 dimer interface [polypeptide binding]; other site 714359010350 active site 714359010351 catalytic residue [active] 714359010352 metal binding site [ion binding]; metal-binding site 714359010353 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 714359010354 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 714359010355 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 714359010356 intersubunit interface [polypeptide binding]; other site 714359010357 active site 714359010358 Zn2+ binding site [ion binding]; other site 714359010359 ARD/ARD' family; Region: ARD; pfam03079 714359010360 Cupin domain; Region: Cupin_2; pfam07883 714359010361 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 714359010362 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 714359010363 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 714359010364 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359010365 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359010366 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714359010367 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359010368 metal binding site [ion binding]; metal-binding site 714359010369 active site 714359010370 I-site; other site 714359010371 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 714359010372 dimer interface [polypeptide binding]; other site 714359010373 FMN binding site [chemical binding]; other site 714359010374 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 714359010375 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 714359010376 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 714359010377 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 714359010378 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 714359010379 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 714359010380 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714359010381 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 714359010382 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714359010383 active site turn [active] 714359010384 phosphorylation site [posttranslational modification] 714359010385 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 714359010386 HPr interaction site; other site 714359010387 glycerol kinase (GK) interaction site [polypeptide binding]; other site 714359010388 active site 714359010389 phosphorylation site [posttranslational modification] 714359010390 transcriptional antiterminator BglG; Provisional; Region: PRK09772 714359010391 CAT RNA binding domain; Region: CAT_RBD; smart01061 714359010392 PRD domain; Region: PRD; pfam00874 714359010393 PRD domain; Region: PRD; pfam00874 714359010394 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359010395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359010396 active site 714359010397 motif I; other site 714359010398 motif II; other site 714359010399 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359010400 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714359010401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359010402 DNA-binding site [nucleotide binding]; DNA binding site 714359010403 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 714359010404 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 714359010405 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 714359010406 active site 714359010407 trimer interface [polypeptide binding]; other site 714359010408 allosteric site; other site 714359010409 active site lid [active] 714359010410 hexamer (dimer of trimers) interface [polypeptide binding]; other site 714359010411 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 714359010412 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 714359010413 active site 714359010414 dimer interface [polypeptide binding]; other site 714359010415 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 714359010416 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359010417 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 714359010418 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 714359010419 Domain of unknown function (DUF309); Region: DUF309; pfam03745 714359010420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359010421 Coenzyme A binding pocket [chemical binding]; other site 714359010422 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 714359010423 active site 714359010424 Predicted secreted protein [Function unknown]; Region: COG4086 714359010425 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 714359010426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 714359010427 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359010428 active site 714359010429 motif I; other site 714359010430 motif II; other site 714359010431 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 714359010432 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 714359010433 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359010434 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 714359010435 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 714359010436 stage V sporulation protein AD; Validated; Region: PRK08304 714359010437 stage V sporulation protein AD; Provisional; Region: PRK12404 714359010438 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 714359010439 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 714359010440 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 714359010441 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 714359010442 Na2 binding site [ion binding]; other site 714359010443 putative substrate binding site 1 [chemical binding]; other site 714359010444 Na binding site 1 [ion binding]; other site 714359010445 putative substrate binding site 2 [chemical binding]; other site 714359010446 sporulation sigma factor SigF; Validated; Region: PRK05572 714359010447 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359010448 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 714359010449 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359010450 DNA binding residues [nucleotide binding] 714359010451 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 714359010452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359010453 ATP binding site [chemical binding]; other site 714359010454 Mg2+ binding site [ion binding]; other site 714359010455 G-X-G motif; other site 714359010456 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 714359010457 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359010458 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714359010459 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 714359010460 Predicted transcriptional regulators [Transcription]; Region: COG1725 714359010461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359010462 DNA-binding site [nucleotide binding]; DNA binding site 714359010463 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359010464 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714359010465 Walker A/P-loop; other site 714359010466 ATP binding site [chemical binding]; other site 714359010467 Q-loop/lid; other site 714359010468 ABC transporter signature motif; other site 714359010469 Walker B; other site 714359010470 D-loop; other site 714359010471 H-loop/switch region; other site 714359010472 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 714359010473 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 714359010474 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 714359010475 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 714359010476 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359010477 MarR family; Region: MarR; pfam01047 714359010478 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 714359010479 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 714359010480 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 714359010481 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 714359010482 oligomer interface [polypeptide binding]; other site 714359010483 metal binding site [ion binding]; metal-binding site 714359010484 metal binding site [ion binding]; metal-binding site 714359010485 putative Cl binding site [ion binding]; other site 714359010486 aspartate ring; other site 714359010487 basic sphincter; other site 714359010488 hydrophobic gate; other site 714359010489 periplasmic entrance; other site 714359010490 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 714359010491 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 714359010492 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 714359010493 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 714359010494 purine nucleoside phosphorylase; Provisional; Region: PRK08202 714359010495 phosphopentomutase; Provisional; Region: PRK05362 714359010496 YtkA-like; Region: YtkA; pfam13115 714359010497 YtkA-like; Region: YtkA; pfam13115 714359010498 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 714359010499 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 714359010500 active site 714359010501 Int/Topo IB signature motif; other site 714359010502 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 714359010503 ferric uptake regulator; Provisional; Region: fur; PRK09462 714359010504 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 714359010505 metal binding site 2 [ion binding]; metal-binding site 714359010506 putative DNA binding helix; other site 714359010507 metal binding site 1 [ion binding]; metal-binding site 714359010508 dimer interface [polypeptide binding]; other site 714359010509 structural Zn2+ binding site [ion binding]; other site 714359010510 stage II sporulation protein M; Region: spo_II_M; TIGR02831 714359010511 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359010512 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359010513 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 714359010514 dimer interface [polypeptide binding]; other site 714359010515 ADP-ribose binding site [chemical binding]; other site 714359010516 active site 714359010517 nudix motif; other site 714359010518 metal binding site [ion binding]; metal-binding site 714359010519 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 714359010520 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359010521 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714359010522 active site 714359010523 catalytic tetrad [active] 714359010524 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359010525 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714359010526 active site 714359010527 catalytic tetrad [active] 714359010528 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 714359010529 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 714359010530 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714359010531 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 714359010532 putative active site [active] 714359010533 putative metal binding site [ion binding]; other site 714359010534 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714359010535 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 714359010536 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 714359010537 Predicted permease [General function prediction only]; Region: COG2056 714359010538 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 714359010539 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 714359010540 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359010541 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359010542 DNA binding site [nucleotide binding] 714359010543 domain linker motif; other site 714359010544 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 714359010545 dimerization interface [polypeptide binding]; other site 714359010546 ligand binding site [chemical binding]; other site 714359010547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359010548 Coenzyme A binding pocket [chemical binding]; other site 714359010549 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359010550 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 714359010551 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 714359010552 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 714359010553 catalytic motif [active] 714359010554 Zn binding site [ion binding]; other site 714359010555 RibD C-terminal domain; Region: RibD_C; cl17279 714359010556 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 714359010557 Lumazine binding domain; Region: Lum_binding; pfam00677 714359010558 Lumazine binding domain; Region: Lum_binding; pfam00677 714359010559 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 714359010560 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 714359010561 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 714359010562 dimerization interface [polypeptide binding]; other site 714359010563 active site 714359010564 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 714359010565 homopentamer interface [polypeptide binding]; other site 714359010566 active site 714359010567 biotin synthase; Validated; Region: PRK06256 714359010568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359010569 FeS/SAM binding site; other site 714359010570 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 714359010571 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 714359010572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359010573 S-adenosylmethionine binding site [chemical binding]; other site 714359010574 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 714359010575 Protein of unknown function (DUF452); Region: DUF452; cl01062 714359010576 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 714359010577 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 714359010578 substrate-cofactor binding pocket; other site 714359010579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359010580 catalytic residue [active] 714359010581 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 714359010582 AAA domain; Region: AAA_26; pfam13500 714359010583 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 714359010584 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359010585 inhibitor-cofactor binding pocket; inhibition site 714359010586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359010587 catalytic residue [active] 714359010588 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714359010589 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 714359010590 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 714359010591 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 714359010592 active site 714359010593 metal binding site [ion binding]; metal-binding site 714359010594 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714359010595 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 714359010596 active site 714359010597 catalytic triad [active] 714359010598 oxyanion hole [active] 714359010599 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 714359010600 ornithine carbamoyltransferase; Provisional; Region: PRK00779 714359010601 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 714359010602 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 714359010603 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 714359010604 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359010605 inhibitor-cofactor binding pocket; inhibition site 714359010606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359010607 catalytic residue [active] 714359010608 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 714359010609 nucleotide binding site [chemical binding]; other site 714359010610 N-acetyl-L-glutamate binding site [chemical binding]; other site 714359010611 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 714359010612 heterotetramer interface [polypeptide binding]; other site 714359010613 active site pocket [active] 714359010614 cleavage site 714359010615 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 714359010616 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 714359010617 YqzH-like protein; Region: YqzH; pfam14164 714359010618 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 714359010619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359010620 NAD(P) binding site [chemical binding]; other site 714359010621 active site 714359010622 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359010623 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 714359010624 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 714359010625 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 714359010626 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 714359010627 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 714359010628 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 714359010629 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 714359010630 putative L-serine binding site [chemical binding]; other site 714359010631 ribonuclease Z; Region: RNase_Z; TIGR02651 714359010632 magnesium-transporting ATPase; Provisional; Region: PRK15122 714359010633 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 714359010634 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359010635 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 714359010636 Soluble P-type ATPase [General function prediction only]; Region: COG4087 714359010637 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 714359010638 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 714359010639 MgtC family; Region: MgtC; pfam02308 714359010640 DNA polymerase IV; Validated; Region: PRK01810 714359010641 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 714359010642 active site 714359010643 DNA binding site [nucleotide binding] 714359010644 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 714359010645 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 714359010646 peptidase T-like protein; Region: PepT-like; TIGR01883 714359010647 metal binding site [ion binding]; metal-binding site 714359010648 putative dimer interface [polypeptide binding]; other site 714359010649 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359010650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 714359010651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 714359010652 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 714359010653 Predicted membrane protein [Function unknown]; Region: COG4129 714359010654 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 714359010655 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 714359010656 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714359010657 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 714359010658 Walker A/P-loop; other site 714359010659 ATP binding site [chemical binding]; other site 714359010660 Q-loop/lid; other site 714359010661 ABC transporter signature motif; other site 714359010662 Walker B; other site 714359010663 D-loop; other site 714359010664 H-loop/switch region; other site 714359010665 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714359010666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359010667 dimer interface [polypeptide binding]; other site 714359010668 conserved gate region; other site 714359010669 putative PBP binding loops; other site 714359010670 ABC-ATPase subunit interface; other site 714359010671 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 714359010672 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359010673 substrate binding pocket [chemical binding]; other site 714359010674 membrane-bound complex binding site; other site 714359010675 hinge residues; other site 714359010676 Disulphide isomerase; Region: Disulph_isomer; pfam06491 714359010677 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 714359010678 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 714359010679 nudix motif; other site 714359010680 Predicted membrane protein [Function unknown]; Region: COG2323 714359010681 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 714359010682 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 714359010683 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714359010684 E3 interaction surface; other site 714359010685 lipoyl attachment site [posttranslational modification]; other site 714359010686 e3 binding domain; Region: E3_binding; pfam02817 714359010687 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 714359010688 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 714359010689 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 714359010690 alpha subunit interface [polypeptide binding]; other site 714359010691 TPP binding site [chemical binding]; other site 714359010692 heterodimer interface [polypeptide binding]; other site 714359010693 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714359010694 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 714359010695 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 714359010696 tetramer interface [polypeptide binding]; other site 714359010697 TPP-binding site [chemical binding]; other site 714359010698 heterodimer interface [polypeptide binding]; other site 714359010699 phosphorylation loop region [posttranslational modification] 714359010700 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 714359010701 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 714359010702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714359010703 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714359010704 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714359010705 nucleotide binding site [chemical binding]; other site 714359010706 Acetokinase family; Region: Acetate_kinase; cl17229 714359010707 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 714359010708 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 714359010709 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 714359010710 NAD binding site [chemical binding]; other site 714359010711 Phe binding site; other site 714359010712 phosphate butyryltransferase; Validated; Region: PRK07742 714359010713 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 714359010714 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 714359010715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359010716 putative active site [active] 714359010717 heme pocket [chemical binding]; other site 714359010718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359010719 putative active site [active] 714359010720 heme pocket [chemical binding]; other site 714359010721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359010722 Walker A motif; other site 714359010723 ATP binding site [chemical binding]; other site 714359010724 Walker B motif; other site 714359010725 arginine finger; other site 714359010726 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 714359010727 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 714359010728 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 714359010729 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 714359010730 active site 714359010731 catalytic site [active] 714359010732 metal binding site [ion binding]; metal-binding site 714359010733 dimer interface [polypeptide binding]; other site 714359010734 YycC-like protein; Region: YycC; pfam14174 714359010735 hypothetical protein; Provisional; Region: PRK06770 714359010736 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 714359010737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359010738 active site 714359010739 phosphorylation site [posttranslational modification] 714359010740 intermolecular recognition site; other site 714359010741 dimerization interface [polypeptide binding]; other site 714359010742 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 714359010743 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 714359010744 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 714359010745 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 714359010746 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 714359010747 arginine repressor; Provisional; Region: PRK04280 714359010748 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 714359010749 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 714359010750 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359010751 RNA binding surface [nucleotide binding]; other site 714359010752 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 714359010753 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 714359010754 TPP-binding site [chemical binding]; other site 714359010755 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 714359010756 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 714359010757 PYR/PP interface [polypeptide binding]; other site 714359010758 dimer interface [polypeptide binding]; other site 714359010759 TPP binding site [chemical binding]; other site 714359010760 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714359010761 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 714359010762 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 714359010763 substrate binding pocket [chemical binding]; other site 714359010764 chain length determination region; other site 714359010765 substrate-Mg2+ binding site; other site 714359010766 catalytic residues [active] 714359010767 aspartate-rich region 1; other site 714359010768 active site lid residues [active] 714359010769 aspartate-rich region 2; other site 714359010770 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 714359010771 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 714359010772 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 714359010773 generic binding surface II; other site 714359010774 generic binding surface I; other site 714359010775 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 714359010776 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 714359010777 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 714359010778 homodimer interface [polypeptide binding]; other site 714359010779 NADP binding site [chemical binding]; other site 714359010780 substrate binding site [chemical binding]; other site 714359010781 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 714359010782 putative RNA binding site [nucleotide binding]; other site 714359010783 Asp23 family; Region: Asp23; pfam03780 714359010784 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 714359010785 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714359010786 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 714359010787 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 714359010788 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 714359010789 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 714359010790 carboxyltransferase (CT) interaction site; other site 714359010791 biotinylation site [posttranslational modification]; other site 714359010792 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 714359010793 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 714359010794 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 714359010795 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 714359010796 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 714359010797 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 714359010798 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 714359010799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359010800 Walker A motif; other site 714359010801 ATP binding site [chemical binding]; other site 714359010802 Walker B motif; other site 714359010803 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 714359010804 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359010805 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359010806 elongation factor P; Validated; Region: PRK00529 714359010807 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 714359010808 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 714359010809 RNA binding site [nucleotide binding]; other site 714359010810 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 714359010811 RNA binding site [nucleotide binding]; other site 714359010812 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 714359010813 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 714359010814 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 714359010815 active site 714359010816 Dehydroquinase class II; Region: DHquinase_II; pfam01220 714359010817 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 714359010818 trimer interface [polypeptide binding]; other site 714359010819 active site 714359010820 dimer interface [polypeptide binding]; other site 714359010821 Conserved membrane protein YqhR; Region: YqhR; pfam11085 714359010822 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 714359010823 Carbon starvation protein CstA; Region: CstA; pfam02554 714359010824 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 714359010825 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 714359010826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359010827 motif II; other site 714359010828 manganese transport transcriptional regulator; Provisional; Region: PRK03902 714359010829 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 714359010830 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 714359010831 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 714359010832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359010833 FeS/SAM binding site; other site 714359010834 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 714359010835 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714359010836 active site residue [active] 714359010837 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359010838 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359010839 DNA binding site [nucleotide binding] 714359010840 domain linker motif; other site 714359010841 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 714359010842 putative dimerization interface [polypeptide binding]; other site 714359010843 putative ligand binding site [chemical binding]; other site 714359010844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359010845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359010846 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 714359010847 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 714359010848 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 714359010849 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 714359010850 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 714359010851 tetramer interface [polypeptide binding]; other site 714359010852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359010853 catalytic residue [active] 714359010854 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 714359010855 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 714359010856 tetramer interface [polypeptide binding]; other site 714359010857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359010858 catalytic residue [active] 714359010859 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 714359010860 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 714359010861 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 714359010862 DEAD-like helicases superfamily; Region: DEXDc; smart00487 714359010863 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359010864 ATP binding site [chemical binding]; other site 714359010865 putative Mg++ binding site [ion binding]; other site 714359010866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359010867 nucleotide binding region [chemical binding]; other site 714359010868 ATP-binding site [chemical binding]; other site 714359010869 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 714359010870 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 714359010871 endonuclease III; Region: ENDO3c; smart00478 714359010872 minor groove reading motif; other site 714359010873 helix-hairpin-helix signature motif; other site 714359010874 substrate binding pocket [chemical binding]; other site 714359010875 active site 714359010876 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 714359010877 A new structural DNA glycosylase; Region: AlkD_like; cd06561 714359010878 active site 714359010879 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 714359010880 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359010881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359010882 putative substrate translocation pore; other site 714359010883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359010884 Radical SAM superfamily; Region: Radical_SAM; pfam04055 714359010885 FeS/SAM binding site; other site 714359010886 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 714359010887 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 714359010888 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 714359010889 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 714359010890 DNA binding site [nucleotide binding] 714359010891 active site 714359010892 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 714359010893 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 714359010894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359010895 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359010896 hypothetical protein; Provisional; Region: PRK07206 714359010897 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 714359010898 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 714359010899 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 714359010900 Cupin domain; Region: Cupin_2; pfam07883 714359010901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359010902 S-adenosylmethionine binding site [chemical binding]; other site 714359010903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359010904 sequence-specific DNA binding site [nucleotide binding]; other site 714359010905 salt bridge; other site 714359010906 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359010907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 714359010908 TPR motif; other site 714359010909 binding surface 714359010910 YqzE-like protein; Region: YqzE; pfam14038 714359010911 shikimate kinase; Reviewed; Region: aroK; PRK00131 714359010912 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 714359010913 ADP binding site [chemical binding]; other site 714359010914 magnesium binding site [ion binding]; other site 714359010915 putative shikimate binding site; other site 714359010916 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 714359010917 ComG operon protein 7; Region: ComGG; pfam14173 714359010918 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 714359010919 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 714359010920 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 714359010921 Type II/IV secretion system protein; Region: T2SE; pfam00437 714359010922 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 714359010923 Walker A motif; other site 714359010924 ATP binding site [chemical binding]; other site 714359010925 Walker B motif; other site 714359010926 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359010927 putative DNA binding site [nucleotide binding]; other site 714359010928 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 714359010929 putative Zn2+ binding site [ion binding]; other site 714359010930 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 714359010931 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 714359010932 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 714359010933 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 714359010934 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 714359010935 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 714359010936 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 714359010937 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 714359010938 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 714359010939 active site 714359010940 homodimer interface [polypeptide binding]; other site 714359010941 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 714359010942 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 714359010943 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 714359010944 substrate binding pocket [chemical binding]; other site 714359010945 dimer interface [polypeptide binding]; other site 714359010946 inhibitor binding site; inhibition site 714359010947 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 714359010948 B12 binding site [chemical binding]; other site 714359010949 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 714359010950 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 714359010951 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 714359010952 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 714359010953 FAD binding site [chemical binding]; other site 714359010954 cystathionine gamma-synthase; Reviewed; Region: PRK08247 714359010955 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 714359010956 homodimer interface [polypeptide binding]; other site 714359010957 substrate-cofactor binding pocket; other site 714359010958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359010959 catalytic residue [active] 714359010960 cystathionine beta-lyase; Provisional; Region: PRK08064 714359010961 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 714359010962 homodimer interface [polypeptide binding]; other site 714359010963 substrate-cofactor binding pocket; other site 714359010964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359010965 catalytic residue [active] 714359010966 Isochorismatase family; Region: Isochorismatase; pfam00857 714359010967 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 714359010968 catalytic triad [active] 714359010969 conserved cis-peptide bond; other site 714359010970 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359010971 dimerization interface [polypeptide binding]; other site 714359010972 putative DNA binding site [nucleotide binding]; other site 714359010973 putative Zn2+ binding site [ion binding]; other site 714359010974 Uncharacterized conserved protein [Function unknown]; Region: COG1565 714359010975 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 714359010976 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 714359010977 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 714359010978 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714359010979 nucleotide binding site [chemical binding]; other site 714359010980 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 714359010981 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 714359010982 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 714359010983 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 714359010984 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 714359010985 active site 714359010986 Substrate binding site; other site 714359010987 Mg++ binding site; other site 714359010988 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 714359010989 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 714359010990 active site 714359010991 metal binding site [ion binding]; metal-binding site 714359010992 substrate binding site [chemical binding]; other site 714359010993 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 714359010994 PhoU domain; Region: PhoU; pfam01895 714359010995 PhoU domain; Region: PhoU; pfam01895 714359010996 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 714359010997 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 714359010998 Walker A/P-loop; other site 714359010999 ATP binding site [chemical binding]; other site 714359011000 Q-loop/lid; other site 714359011001 ABC transporter signature motif; other site 714359011002 Walker B; other site 714359011003 D-loop; other site 714359011004 H-loop/switch region; other site 714359011005 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 714359011006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359011007 dimer interface [polypeptide binding]; other site 714359011008 conserved gate region; other site 714359011009 putative PBP binding loops; other site 714359011010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 714359011011 ABC-ATPase subunit interface; other site 714359011012 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 714359011013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359011014 dimer interface [polypeptide binding]; other site 714359011015 conserved gate region; other site 714359011016 putative PBP binding loops; other site 714359011017 ABC-ATPase subunit interface; other site 714359011018 PBP superfamily domain; Region: PBP_like_2; cl17296 714359011019 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 714359011020 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359011021 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359011022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359011023 putative substrate translocation pore; other site 714359011024 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359011025 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 714359011026 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 714359011027 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 714359011028 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 714359011029 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 714359011030 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 714359011031 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 714359011032 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 714359011033 metal binding site 2 [ion binding]; metal-binding site 714359011034 putative DNA binding helix; other site 714359011035 metal binding site 1 [ion binding]; metal-binding site 714359011036 dimer interface [polypeptide binding]; other site 714359011037 structural Zn2+ binding site [ion binding]; other site 714359011038 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 714359011039 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359011040 ABC-ATPase subunit interface; other site 714359011041 dimer interface [polypeptide binding]; other site 714359011042 putative PBP binding regions; other site 714359011043 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 714359011044 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 714359011045 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359011046 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359011047 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 714359011048 endonuclease IV; Provisional; Region: PRK01060 714359011049 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 714359011050 AP (apurinic/apyrimidinic) site pocket; other site 714359011051 DNA interaction; other site 714359011052 Metal-binding active site; metal-binding site 714359011053 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714359011054 DEAD-like helicases superfamily; Region: DEXDc; smart00487 714359011055 ATP binding site [chemical binding]; other site 714359011056 Mg++ binding site [ion binding]; other site 714359011057 motif III; other site 714359011058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359011059 nucleotide binding region [chemical binding]; other site 714359011060 ATP-binding site [chemical binding]; other site 714359011061 YqfQ-like protein; Region: YqfQ; pfam14181 714359011062 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 714359011063 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 714359011064 Uncharacterized conserved protein [Function unknown]; Region: COG0327 714359011065 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 714359011066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 714359011067 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 714359011068 Uncharacterized conserved protein [Function unknown]; Region: COG0327 714359011069 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 714359011070 Family of unknown function (DUF633); Region: DUF633; pfam04816 714359011071 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 714359011072 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 714359011073 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 714359011074 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 714359011075 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 714359011076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359011077 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 714359011078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359011079 DNA binding residues [nucleotide binding] 714359011080 DNA primase; Validated; Region: dnaG; PRK05667 714359011081 CHC2 zinc finger; Region: zf-CHC2; pfam01807 714359011082 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 714359011083 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 714359011084 active site 714359011085 metal binding site [ion binding]; metal-binding site 714359011086 interdomain interaction site; other site 714359011087 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 714359011088 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 714359011089 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 714359011090 PEP synthetase regulatory protein; Provisional; Region: PRK05339 714359011091 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 714359011092 FOG: CBS domain [General function prediction only]; Region: COG0517 714359011093 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 714359011094 Recombination protein O N terminal; Region: RecO_N; pfam11967 714359011095 Recombination protein O C terminal; Region: RecO_C; pfam02565 714359011096 YqzL-like protein; Region: YqzL; pfam14006 714359011097 GTPase Era; Reviewed; Region: era; PRK00089 714359011098 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 714359011099 G1 box; other site 714359011100 GTP/Mg2+ binding site [chemical binding]; other site 714359011101 Switch I region; other site 714359011102 G2 box; other site 714359011103 Switch II region; other site 714359011104 G3 box; other site 714359011105 G4 box; other site 714359011106 G5 box; other site 714359011107 KH domain; Region: KH_2; pfam07650 714359011108 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 714359011109 active site 714359011110 catalytic motif [active] 714359011111 Zn binding site [ion binding]; other site 714359011112 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 714359011113 metal-binding heat shock protein; Provisional; Region: PRK00016 714359011114 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 714359011115 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 714359011116 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359011117 Zn2+ binding site [ion binding]; other site 714359011118 Mg2+ binding site [ion binding]; other site 714359011119 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 714359011120 PhoH-like protein; Region: PhoH; pfam02562 714359011121 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 714359011122 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 714359011123 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 714359011124 Yqey-like protein; Region: YqeY; pfam09424 714359011125 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 714359011126 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 714359011127 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 714359011128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359011129 FeS/SAM binding site; other site 714359011130 TRAM domain; Region: TRAM; cl01282 714359011131 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 714359011132 RNA methyltransferase, RsmE family; Region: TIGR00046 714359011133 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 714359011134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359011135 S-adenosylmethionine binding site [chemical binding]; other site 714359011136 chaperone protein DnaJ; Provisional; Region: PRK14280 714359011137 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 714359011138 HSP70 interaction site [polypeptide binding]; other site 714359011139 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 714359011140 substrate binding site [polypeptide binding]; other site 714359011141 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 714359011142 Zn binding sites [ion binding]; other site 714359011143 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 714359011144 dimer interface [polypeptide binding]; other site 714359011145 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 714359011146 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 714359011147 nucleotide binding site [chemical binding]; other site 714359011148 NEF interaction site [polypeptide binding]; other site 714359011149 SBD interface [polypeptide binding]; other site 714359011150 GrpE; Region: GrpE; pfam01025 714359011151 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 714359011152 dimer interface [polypeptide binding]; other site 714359011153 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 714359011154 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 714359011155 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 714359011156 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 714359011157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359011158 FeS/SAM binding site; other site 714359011159 HemN C-terminal domain; Region: HemN_C; pfam06969 714359011160 Predicted transcriptional regulators [Transcription]; Region: COG1733 714359011161 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 714359011162 GTP-binding protein LepA; Provisional; Region: PRK05433 714359011163 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 714359011164 G1 box; other site 714359011165 putative GEF interaction site [polypeptide binding]; other site 714359011166 GTP/Mg2+ binding site [chemical binding]; other site 714359011167 Switch I region; other site 714359011168 G2 box; other site 714359011169 G3 box; other site 714359011170 Switch II region; other site 714359011171 G4 box; other site 714359011172 G5 box; other site 714359011173 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 714359011174 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 714359011175 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 714359011176 germination protease; Provisional; Region: PRK02858 714359011177 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 714359011178 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 714359011179 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 714359011180 YqzM-like protein; Region: YqzM; pfam14141 714359011181 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 714359011182 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 714359011183 Competence protein; Region: Competence; pfam03772 714359011184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359011185 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 714359011186 catalytic motif [active] 714359011187 Zn binding site [ion binding]; other site 714359011188 SLBB domain; Region: SLBB; pfam10531 714359011189 comEA protein; Region: comE; TIGR01259 714359011190 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 714359011191 late competence protein ComER; Validated; Region: PRK07680 714359011192 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 714359011193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359011194 S-adenosylmethionine binding site [chemical binding]; other site 714359011195 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 714359011196 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 714359011197 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359011198 Zn2+ binding site [ion binding]; other site 714359011199 Mg2+ binding site [ion binding]; other site 714359011200 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 714359011201 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 714359011202 active site 714359011203 (T/H)XGH motif; other site 714359011204 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 714359011205 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 714359011206 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 714359011207 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 714359011208 shikimate binding site; other site 714359011209 NAD(P) binding site [chemical binding]; other site 714359011210 GTPase YqeH; Provisional; Region: PRK13796 714359011211 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 714359011212 GTP/Mg2+ binding site [chemical binding]; other site 714359011213 G4 box; other site 714359011214 G5 box; other site 714359011215 G1 box; other site 714359011216 Switch I region; other site 714359011217 G2 box; other site 714359011218 G3 box; other site 714359011219 Switch II region; other site 714359011220 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 714359011221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359011222 active site 714359011223 motif I; other site 714359011224 motif II; other site 714359011225 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 714359011226 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 714359011227 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359011228 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359011229 DNA binding residues [nucleotide binding] 714359011230 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359011231 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 714359011232 dimer interface [polypeptide binding]; other site 714359011233 FMN binding site [chemical binding]; other site 714359011234 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 714359011235 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 714359011236 synthetase active site [active] 714359011237 NTP binding site [chemical binding]; other site 714359011238 metal binding site [ion binding]; metal-binding site 714359011239 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 714359011240 dimer interface [polypeptide binding]; other site 714359011241 Alkaline phosphatase homologues; Region: alkPPc; smart00098 714359011242 active site 714359011243 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359011244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359011245 Coenzyme A binding pocket [chemical binding]; other site 714359011246 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 714359011247 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359011248 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 714359011249 catalytic site [active] 714359011250 CHAT domain; Region: CHAT; cl17868 714359011251 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 714359011252 catalytic core [active] 714359011253 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 714359011254 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 714359011255 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 714359011256 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 714359011257 putative active site [active] 714359011258 catalytic triad [active] 714359011259 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 714359011260 putative integrin binding motif; other site 714359011261 PA/protease domain interface [polypeptide binding]; other site 714359011262 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 714359011263 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 714359011264 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 714359011265 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 714359011266 cofactor binding site; other site 714359011267 metal binding site [ion binding]; metal-binding site 714359011268 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 714359011269 aromatic arch; other site 714359011270 DCoH dimer interaction site [polypeptide binding]; other site 714359011271 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 714359011272 DCoH tetramer interaction site [polypeptide binding]; other site 714359011273 substrate binding site [chemical binding]; other site 714359011274 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 714359011275 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 714359011276 putative metal binding site [ion binding]; other site 714359011277 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359011278 active site 714359011279 Predicted membrane protein [Function unknown]; Region: COG2259 714359011280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359011281 non-specific DNA binding site [nucleotide binding]; other site 714359011282 salt bridge; other site 714359011283 sequence-specific DNA binding site [nucleotide binding]; other site 714359011284 Cupin domain; Region: Cupin_2; pfam07883 714359011285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359011286 Coenzyme A binding pocket [chemical binding]; other site 714359011287 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359011288 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359011289 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 714359011290 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 714359011291 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714359011292 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714359011293 Walker A/P-loop; other site 714359011294 ATP binding site [chemical binding]; other site 714359011295 Q-loop/lid; other site 714359011296 ABC transporter signature motif; other site 714359011297 Walker B; other site 714359011298 D-loop; other site 714359011299 H-loop/switch region; other site 714359011300 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714359011301 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359011302 ABC-ATPase subunit interface; other site 714359011303 dimer interface [polypeptide binding]; other site 714359011304 putative PBP binding regions; other site 714359011305 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 714359011306 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 714359011307 intersubunit interface [polypeptide binding]; other site 714359011308 YrhC-like protein; Region: YrhC; pfam14143 714359011309 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 714359011310 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 714359011311 putative catalytic cysteine [active] 714359011312 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 714359011313 putative active site [active] 714359011314 metal binding site [ion binding]; metal-binding site 714359011315 cystathionine beta-lyase; Provisional; Region: PRK07671 714359011316 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 714359011317 homodimer interface [polypeptide binding]; other site 714359011318 substrate-cofactor binding pocket; other site 714359011319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359011320 catalytic residue [active] 714359011321 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 714359011322 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 714359011323 dimer interface [polypeptide binding]; other site 714359011324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359011325 catalytic residue [active] 714359011326 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 714359011327 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 714359011328 Methyltransferase domain; Region: Methyltransf_23; pfam13489 714359011329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359011330 S-adenosylmethionine binding site [chemical binding]; other site 714359011331 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 714359011332 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 714359011333 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 714359011334 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359011335 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359011336 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 714359011337 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 714359011338 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 714359011339 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 714359011340 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 714359011341 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 714359011342 ATP-binding site [chemical binding]; other site 714359011343 Sugar specificity; other site 714359011344 Pyrimidine base specificity; other site 714359011345 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 714359011346 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 714359011347 Peptidase family U32; Region: Peptidase_U32; pfam01136 714359011348 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 714359011349 Protein of unknown function (DUF556); Region: DUF556; cl00822 714359011350 Peptidase family U32; Region: Peptidase_U32; pfam01136 714359011351 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 714359011352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359011353 S-adenosylmethionine binding site [chemical binding]; other site 714359011354 YceG-like family; Region: YceG; pfam02618 714359011355 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 714359011356 dimerization interface [polypeptide binding]; other site 714359011357 hypothetical protein; Provisional; Region: PRK13678 714359011358 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 714359011359 hypothetical protein; Provisional; Region: PRK05473 714359011360 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 714359011361 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 714359011362 motif 1; other site 714359011363 active site 714359011364 motif 2; other site 714359011365 motif 3; other site 714359011366 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 714359011367 DHHA1 domain; Region: DHHA1; pfam02272 714359011368 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 714359011369 Domain of unknown function DUF20; Region: UPF0118; pfam01594 714359011370 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 714359011371 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 714359011372 AAA domain; Region: AAA_30; pfam13604 714359011373 Family description; Region: UvrD_C_2; pfam13538 714359011374 glutamyl-tRNA reductase; Region: hemA; TIGR01035 714359011375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359011376 TPR motif; other site 714359011377 TPR repeat; Region: TPR_11; pfam13414 714359011378 binding surface 714359011379 TPR repeat; Region: TPR_11; pfam13414 714359011380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359011381 binding surface 714359011382 TPR motif; other site 714359011383 TPR repeat; Region: TPR_11; pfam13414 714359011384 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 714359011385 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 714359011386 Ligand Binding Site [chemical binding]; other site 714359011387 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 714359011388 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 714359011389 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359011390 catalytic residue [active] 714359011391 Predicted transcriptional regulator [Transcription]; Region: COG1959 714359011392 Transcriptional regulator; Region: Rrf2; pfam02082 714359011393 recombination factor protein RarA; Reviewed; Region: PRK13342 714359011394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359011395 Walker A motif; other site 714359011396 ATP binding site [chemical binding]; other site 714359011397 Walker B motif; other site 714359011398 arginine finger; other site 714359011399 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 714359011400 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 714359011401 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 714359011402 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 714359011403 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 714359011404 putative ATP binding site [chemical binding]; other site 714359011405 putative substrate interface [chemical binding]; other site 714359011406 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 714359011407 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 714359011408 dimer interface [polypeptide binding]; other site 714359011409 anticodon binding site; other site 714359011410 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 714359011411 homodimer interface [polypeptide binding]; other site 714359011412 motif 1; other site 714359011413 active site 714359011414 motif 2; other site 714359011415 GAD domain; Region: GAD; pfam02938 714359011416 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 714359011417 motif 3; other site 714359011418 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 714359011419 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 714359011420 dimer interface [polypeptide binding]; other site 714359011421 motif 1; other site 714359011422 active site 714359011423 motif 2; other site 714359011424 motif 3; other site 714359011425 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 714359011426 anticodon binding site; other site 714359011427 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 714359011428 putative active site [active] 714359011429 dimerization interface [polypeptide binding]; other site 714359011430 putative tRNAtyr binding site [nucleotide binding]; other site 714359011431 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 714359011432 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359011433 Zn2+ binding site [ion binding]; other site 714359011434 Mg2+ binding site [ion binding]; other site 714359011435 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 714359011436 synthetase active site [active] 714359011437 NTP binding site [chemical binding]; other site 714359011438 metal binding site [ion binding]; metal-binding site 714359011439 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 714359011440 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 714359011441 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714359011442 active site 714359011443 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 714359011444 DHH family; Region: DHH; pfam01368 714359011445 DHHA1 domain; Region: DHHA1; pfam02272 714359011446 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 714359011447 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 714359011448 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 714359011449 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 714359011450 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 714359011451 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 714359011452 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 714359011453 Protein export membrane protein; Region: SecD_SecF; pfam02355 714359011454 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 714359011455 stage V sporulation protein B; Region: spore_V_B; TIGR02900 714359011456 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 714359011457 Predicted membrane protein [Function unknown]; Region: COG2323 714359011458 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 714359011459 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 714359011460 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 714359011461 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 714359011462 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 714359011463 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 714359011464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359011465 Walker A motif; other site 714359011466 ATP binding site [chemical binding]; other site 714359011467 Walker B motif; other site 714359011468 arginine finger; other site 714359011469 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 714359011470 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 714359011471 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 714359011472 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 714359011473 putative ligand binding residues [chemical binding]; other site 714359011474 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 714359011475 BofC C-terminal domain; Region: BofC_C; pfam08955 714359011476 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 714359011477 quinolinate synthetase; Provisional; Region: PRK09375 714359011478 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 714359011479 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 714359011480 dimerization interface [polypeptide binding]; other site 714359011481 active site 714359011482 L-aspartate oxidase; Provisional; Region: PRK08071 714359011483 L-aspartate oxidase; Provisional; Region: PRK06175 714359011484 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 714359011485 cysteine desulfurase; Provisional; Region: PRK02948 714359011486 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 714359011487 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359011488 catalytic residue [active] 714359011489 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 714359011490 HTH domain; Region: HTH_11; pfam08279 714359011491 3H domain; Region: 3H; pfam02829 714359011492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 714359011493 MOSC domain; Region: MOSC; pfam03473 714359011494 3-alpha domain; Region: 3-alpha; pfam03475 714359011495 prephenate dehydratase; Provisional; Region: PRK11898 714359011496 Prephenate dehydratase; Region: PDT; pfam00800 714359011497 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 714359011498 putative L-Phe binding site [chemical binding]; other site 714359011499 FtsX-like permease family; Region: FtsX; pfam02687 714359011500 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 714359011501 FtsX-like permease family; Region: FtsX; pfam02687 714359011502 FtsX-like permease family; Region: FtsX; pfam02687 714359011503 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359011504 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714359011505 Walker A/P-loop; other site 714359011506 ATP binding site [chemical binding]; other site 714359011507 Q-loop/lid; other site 714359011508 ABC transporter signature motif; other site 714359011509 Walker B; other site 714359011510 D-loop; other site 714359011511 H-loop/switch region; other site 714359011512 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359011513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 714359011514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359011515 ATP binding site [chemical binding]; other site 714359011516 Mg2+ binding site [ion binding]; other site 714359011517 G-X-G motif; other site 714359011518 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359011519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359011520 active site 714359011521 phosphorylation site [posttranslational modification] 714359011522 intermolecular recognition site; other site 714359011523 dimerization interface [polypeptide binding]; other site 714359011524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359011525 DNA binding site [nucleotide binding] 714359011526 GTPase CgtA; Reviewed; Region: obgE; PRK12297 714359011527 GTP1/OBG; Region: GTP1_OBG; pfam01018 714359011528 Obg GTPase; Region: Obg; cd01898 714359011529 G1 box; other site 714359011530 GTP/Mg2+ binding site [chemical binding]; other site 714359011531 Switch I region; other site 714359011532 G2 box; other site 714359011533 G3 box; other site 714359011534 Switch II region; other site 714359011535 G4 box; other site 714359011536 G5 box; other site 714359011537 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 714359011538 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 714359011539 hypothetical protein; Provisional; Region: PRK14553 714359011540 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 714359011541 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 714359011542 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 714359011543 homodimer interface [polypeptide binding]; other site 714359011544 oligonucleotide binding site [chemical binding]; other site 714359011545 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 714359011546 Peptidase family M50; Region: Peptidase_M50; pfam02163 714359011547 putative substrate binding region [chemical binding]; other site 714359011548 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 714359011549 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359011550 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 714359011551 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 714359011552 Switch II; other site 714359011553 septum formation inhibitor; Reviewed; Region: minC; PRK00513 714359011554 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 714359011555 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 714359011556 rod shape-determining protein MreC; Provisional; Region: PRK13922 714359011557 rod shape-determining protein MreC; Region: MreC; pfam04085 714359011558 rod shape-determining protein MreB; Provisional; Region: PRK13927 714359011559 MreB and similar proteins; Region: MreB_like; cd10225 714359011560 nucleotide binding site [chemical binding]; other site 714359011561 Mg binding site [ion binding]; other site 714359011562 putative protofilament interaction site [polypeptide binding]; other site 714359011563 RodZ interaction site [polypeptide binding]; other site 714359011564 hypothetical protein; Reviewed; Region: PRK00024 714359011565 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 714359011566 MPN+ (JAMM) motif; other site 714359011567 Zinc-binding site [ion binding]; other site 714359011568 Maf-like protein; Region: Maf; pfam02545 714359011569 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 714359011570 active site 714359011571 dimer interface [polypeptide binding]; other site 714359011572 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 714359011573 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714359011574 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714359011575 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 714359011576 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 714359011577 active site 714359011578 HIGH motif; other site 714359011579 nucleotide binding site [chemical binding]; other site 714359011580 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 714359011581 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 714359011582 active site 714359011583 KMSKS motif; other site 714359011584 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 714359011585 tRNA binding surface [nucleotide binding]; other site 714359011586 anticodon binding site; other site 714359011587 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 714359011588 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 714359011589 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 714359011590 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 714359011591 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714359011592 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 714359011593 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359011594 inhibitor-cofactor binding pocket; inhibition site 714359011595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359011596 catalytic residue [active] 714359011597 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 714359011598 dimer interface [polypeptide binding]; other site 714359011599 active site 714359011600 Schiff base residues; other site 714359011601 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 714359011602 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 714359011603 active site 714359011604 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 714359011605 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 714359011606 domain interfaces; other site 714359011607 active site 714359011608 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 714359011609 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 714359011610 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 714359011611 tRNA; other site 714359011612 putative NADP binding site [chemical binding]; other site 714359011613 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 714359011614 Transcriptional regulators [Transcription]; Region: MarR; COG1846 714359011615 MarR family; Region: MarR; pfam01047 714359011616 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 714359011617 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 714359011618 G1 box; other site 714359011619 GTP/Mg2+ binding site [chemical binding]; other site 714359011620 Switch I region; other site 714359011621 G2 box; other site 714359011622 G3 box; other site 714359011623 Switch II region; other site 714359011624 G4 box; other site 714359011625 G5 box; other site 714359011626 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 714359011627 Found in ATP-dependent protease La (LON); Region: LON; smart00464 714359011628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359011629 Walker A motif; other site 714359011630 ATP binding site [chemical binding]; other site 714359011631 Walker B motif; other site 714359011632 arginine finger; other site 714359011633 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 714359011634 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 714359011635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359011636 Walker A motif; other site 714359011637 ATP binding site [chemical binding]; other site 714359011638 Walker B motif; other site 714359011639 arginine finger; other site 714359011640 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 714359011641 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 714359011642 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 714359011643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359011644 Walker A motif; other site 714359011645 ATP binding site [chemical binding]; other site 714359011646 Walker B motif; other site 714359011647 arginine finger; other site 714359011648 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 714359011649 trigger factor; Provisional; Region: tig; PRK01490 714359011650 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 714359011651 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 714359011652 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 714359011653 pentamer interface [polypeptide binding]; other site 714359011654 dodecaamer interface [polypeptide binding]; other site 714359011655 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 714359011656 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 714359011657 active site 714359011658 metal binding site [ion binding]; metal-binding site 714359011659 homotetramer interface [polypeptide binding]; other site 714359011660 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 714359011661 active site 714359011662 dimerization interface [polypeptide binding]; other site 714359011663 ribonuclease PH; Reviewed; Region: rph; PRK00173 714359011664 Ribonuclease PH; Region: RNase_PH_bact; cd11362 714359011665 hexamer interface [polypeptide binding]; other site 714359011666 active site 714359011667 Sporulation and spore germination; Region: Germane; pfam10646 714359011668 Spore germination protein [General function prediction only]; Region: COG5401 714359011669 Sporulation and spore germination; Region: Germane; pfam10646 714359011670 glutamate racemase; Provisional; Region: PRK00865 714359011671 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359011672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359011673 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 714359011674 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 714359011675 potential catalytic triad [active] 714359011676 conserved cys residue [active] 714359011677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359011678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359011679 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 714359011680 intracellular protease, PfpI family; Region: PfpI; TIGR01382 714359011681 potential catalytic triad [active] 714359011682 conserved cys residue [active] 714359011683 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359011684 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359011685 DNA binding residues [nucleotide binding] 714359011686 dimerization interface [polypeptide binding]; other site 714359011687 putative uracil/xanthine transporter; Provisional; Region: PRK11412 714359011688 putative deaminase; Validated; Region: PRK06846 714359011689 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 714359011690 active site 714359011691 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 714359011692 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359011693 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359011694 non-specific DNA binding site [nucleotide binding]; other site 714359011695 salt bridge; other site 714359011696 sequence-specific DNA binding site [nucleotide binding]; other site 714359011697 Cupin domain; Region: Cupin_2; pfam07883 714359011698 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 714359011699 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 714359011700 amphipathic channel; other site 714359011701 Asn-Pro-Ala signature motifs; other site 714359011702 Predicted transcriptional regulator [Transcription]; Region: COG1959 714359011703 Transcriptional regulator; Region: Rrf2; pfam02082 714359011704 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 714359011705 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 714359011706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359011707 Walker A/P-loop; other site 714359011708 ATP binding site [chemical binding]; other site 714359011709 Q-loop/lid; other site 714359011710 ABC transporter signature motif; other site 714359011711 Walker B; other site 714359011712 D-loop; other site 714359011713 H-loop/switch region; other site 714359011714 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 714359011715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359011716 active site 714359011717 motif I; other site 714359011718 motif II; other site 714359011719 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 714359011720 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 714359011721 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 714359011722 ligand binding site [chemical binding]; other site 714359011723 flagellar motor protein MotA; Validated; Region: PRK08124 714359011724 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 714359011725 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 714359011726 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 714359011727 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 714359011728 active site 714359011729 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 714359011730 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 714359011731 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714359011732 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 714359011733 L-aspartate oxidase; Provisional; Region: PRK06175 714359011734 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 714359011735 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 714359011736 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 714359011737 putative Iron-sulfur protein interface [polypeptide binding]; other site 714359011738 proximal heme binding site [chemical binding]; other site 714359011739 distal heme binding site [chemical binding]; other site 714359011740 putative dimer interface [polypeptide binding]; other site 714359011741 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 714359011742 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 714359011743 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 714359011744 active site 714359011745 catalytic site [active] 714359011746 putative DNA binding site [nucleotide binding]; other site 714359011747 GIY-YIG motif/motif A; other site 714359011748 metal binding site [ion binding]; metal-binding site 714359011749 UvrB/uvrC motif; Region: UVR; pfam02151 714359011750 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 714359011751 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359011752 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 714359011753 catalytic residues [active] 714359011754 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 714359011755 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 714359011756 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 714359011757 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 714359011758 Ligand binding site [chemical binding]; other site 714359011759 Electron transfer flavoprotein domain; Region: ETF; pfam01012 714359011760 enoyl-CoA hydratase; Provisional; Region: PRK07658 714359011761 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714359011762 substrate binding site [chemical binding]; other site 714359011763 oxyanion hole (OAH) forming residues; other site 714359011764 trimer interface [polypeptide binding]; other site 714359011765 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 714359011766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359011767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359011768 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 714359011769 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 714359011770 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 714359011771 acyl-activating enzyme (AAE) consensus motif; other site 714359011772 putative AMP binding site [chemical binding]; other site 714359011773 putative active site [active] 714359011774 putative CoA binding site [chemical binding]; other site 714359011775 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 714359011776 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 714359011777 siderophore binding site; other site 714359011778 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714359011779 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359011780 ABC-ATPase subunit interface; other site 714359011781 dimer interface [polypeptide binding]; other site 714359011782 putative PBP binding regions; other site 714359011783 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359011784 ABC-ATPase subunit interface; other site 714359011785 dimer interface [polypeptide binding]; other site 714359011786 putative PBP binding regions; other site 714359011787 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 714359011788 DinB family; Region: DinB; pfam05163 714359011789 DinB superfamily; Region: DinB_2; pfam12867 714359011790 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 714359011791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 714359011792 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 714359011793 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 714359011794 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 714359011795 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 714359011796 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 714359011797 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359011798 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 714359011799 Walker A/P-loop; other site 714359011800 ATP binding site [chemical binding]; other site 714359011801 Q-loop/lid; other site 714359011802 ABC transporter signature motif; other site 714359011803 Walker B; other site 714359011804 D-loop; other site 714359011805 H-loop/switch region; other site 714359011806 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359011807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359011808 dimer interface [polypeptide binding]; other site 714359011809 phosphorylation site [posttranslational modification] 714359011810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359011811 ATP binding site [chemical binding]; other site 714359011812 Mg2+ binding site [ion binding]; other site 714359011813 G-X-G motif; other site 714359011814 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359011815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359011816 active site 714359011817 phosphorylation site [posttranslational modification] 714359011818 intermolecular recognition site; other site 714359011819 dimerization interface [polypeptide binding]; other site 714359011820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359011821 DNA binding site [nucleotide binding] 714359011822 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 714359011823 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 714359011824 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 714359011825 putative RNA binding site [nucleotide binding]; other site 714359011826 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 714359011827 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 714359011828 active site 714359011829 catalytic site [active] 714359011830 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714359011831 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714359011832 Walker A/P-loop; other site 714359011833 ATP binding site [chemical binding]; other site 714359011834 Q-loop/lid; other site 714359011835 ABC transporter signature motif; other site 714359011836 Walker B; other site 714359011837 D-loop; other site 714359011838 H-loop/switch region; other site 714359011839 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 714359011840 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359011841 ABC-ATPase subunit interface; other site 714359011842 dimer interface [polypeptide binding]; other site 714359011843 putative PBP binding regions; other site 714359011844 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 714359011845 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 714359011846 intersubunit interface [polypeptide binding]; other site 714359011847 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359011848 heme-binding site [chemical binding]; other site 714359011849 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359011850 heme-binding site [chemical binding]; other site 714359011851 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359011852 heme-binding site [chemical binding]; other site 714359011853 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359011854 heme-binding site [chemical binding]; other site 714359011855 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359011856 heme-binding site [chemical binding]; other site 714359011857 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359011858 heme-binding site [chemical binding]; other site 714359011859 heme uptake protein IsdC; Region: IsdC; TIGR03656 714359011860 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359011861 heme-binding site [chemical binding]; other site 714359011862 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 714359011863 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 714359011864 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 714359011865 pseudouridine synthase; Region: TIGR00093 714359011866 probable active site [active] 714359011867 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 714359011868 MutS domain III; Region: MutS_III; pfam05192 714359011869 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 714359011870 Walker A/P-loop; other site 714359011871 ATP binding site [chemical binding]; other site 714359011872 Q-loop/lid; other site 714359011873 ABC transporter signature motif; other site 714359011874 Walker B; other site 714359011875 D-loop; other site 714359011876 H-loop/switch region; other site 714359011877 Smr domain; Region: Smr; pfam01713 714359011878 hypothetical protein; Provisional; Region: PRK08609 714359011879 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 714359011880 active site 714359011881 primer binding site [nucleotide binding]; other site 714359011882 NTP binding site [chemical binding]; other site 714359011883 metal binding triad [ion binding]; metal-binding site 714359011884 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 714359011885 active site 714359011886 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 714359011887 Colicin V production protein; Region: Colicin_V; pfam02674 714359011888 cell division protein ZapA; Provisional; Region: PRK14126 714359011889 ribonuclease HIII; Provisional; Region: PRK00996 714359011890 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 714359011891 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 714359011892 RNA/DNA hybrid binding site [nucleotide binding]; other site 714359011893 active site 714359011894 short chain dehydrogenase; Provisional; Region: PRK06197 714359011895 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 714359011896 putative NAD(P) binding site [chemical binding]; other site 714359011897 active site 714359011898 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 714359011899 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 714359011900 putative dimer interface [polypeptide binding]; other site 714359011901 putative anticodon binding site; other site 714359011902 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 714359011903 homodimer interface [polypeptide binding]; other site 714359011904 motif 1; other site 714359011905 motif 2; other site 714359011906 active site 714359011907 motif 3; other site 714359011908 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 714359011909 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 714359011910 putative tRNA-binding site [nucleotide binding]; other site 714359011911 B3/4 domain; Region: B3_4; pfam03483 714359011912 tRNA synthetase B5 domain; Region: B5; smart00874 714359011913 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 714359011914 dimer interface [polypeptide binding]; other site 714359011915 motif 1; other site 714359011916 motif 3; other site 714359011917 motif 2; other site 714359011918 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 714359011919 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 714359011920 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 714359011921 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 714359011922 dimer interface [polypeptide binding]; other site 714359011923 motif 1; other site 714359011924 active site 714359011925 motif 2; other site 714359011926 motif 3; other site 714359011927 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 714359011928 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 714359011929 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 714359011930 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 714359011931 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359011932 Zn2+ binding site [ion binding]; other site 714359011933 Mg2+ binding site [ion binding]; other site 714359011934 CAAX protease self-immunity; Region: Abi; pfam02517 714359011935 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359011936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359011937 putative substrate translocation pore; other site 714359011938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359011939 HlyD family secretion protein; Region: HlyD_3; pfam13437 714359011940 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 714359011941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359011942 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 714359011943 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 714359011944 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 714359011945 oligomer interface [polypeptide binding]; other site 714359011946 active site 714359011947 metal binding site [ion binding]; metal-binding site 714359011948 dUTPase; Region: dUTPase_2; pfam08761 714359011949 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 714359011950 active site 714359011951 homodimer interface [polypeptide binding]; other site 714359011952 metal binding site [ion binding]; metal-binding site 714359011953 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 714359011954 23S rRNA binding site [nucleotide binding]; other site 714359011955 L21 binding site [polypeptide binding]; other site 714359011956 L13 binding site [polypeptide binding]; other site 714359011957 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 714359011958 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 714359011959 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 714359011960 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 714359011961 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 714359011962 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 714359011963 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 714359011964 active site 714359011965 dimer interface [polypeptide binding]; other site 714359011966 motif 1; other site 714359011967 motif 2; other site 714359011968 motif 3; other site 714359011969 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 714359011970 anticodon binding site; other site 714359011971 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 714359011972 primosomal protein DnaI; Reviewed; Region: PRK08939 714359011973 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 714359011974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359011975 Walker A motif; other site 714359011976 ATP binding site [chemical binding]; other site 714359011977 Walker B motif; other site 714359011978 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 714359011979 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 714359011980 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 714359011981 ATP cone domain; Region: ATP-cone; pfam03477 714359011982 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 714359011983 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 714359011984 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 714359011985 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 714359011986 dephospho-CoA kinase; Region: TIGR00152 714359011987 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 714359011988 CoA-binding site [chemical binding]; other site 714359011989 ATP-binding [chemical binding]; other site 714359011990 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 714359011991 Domain of unknown function DUF; Region: DUF204; pfam02659 714359011992 Domain of unknown function DUF; Region: DUF204; pfam02659 714359011993 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 714359011994 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 714359011995 DNA binding site [nucleotide binding] 714359011996 catalytic residue [active] 714359011997 H2TH interface [polypeptide binding]; other site 714359011998 putative catalytic residues [active] 714359011999 turnover-facilitating residue; other site 714359012000 intercalation triad [nucleotide binding]; other site 714359012001 8OG recognition residue [nucleotide binding]; other site 714359012002 putative reading head residues; other site 714359012003 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 714359012004 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 714359012005 DNA polymerase I; Provisional; Region: PRK05755 714359012006 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 714359012007 active site 714359012008 metal binding site 1 [ion binding]; metal-binding site 714359012009 putative 5' ssDNA interaction site; other site 714359012010 metal binding site 3; metal-binding site 714359012011 metal binding site 2 [ion binding]; metal-binding site 714359012012 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 714359012013 putative DNA binding site [nucleotide binding]; other site 714359012014 putative metal binding site [ion binding]; other site 714359012015 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 714359012016 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 714359012017 active site 714359012018 DNA binding site [nucleotide binding] 714359012019 catalytic site [active] 714359012020 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359012021 dimerization interface [polypeptide binding]; other site 714359012022 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 714359012023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359012024 putative active site [active] 714359012025 heme pocket [chemical binding]; other site 714359012026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359012027 dimer interface [polypeptide binding]; other site 714359012028 phosphorylation site [posttranslational modification] 714359012029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359012030 ATP binding site [chemical binding]; other site 714359012031 Mg2+ binding site [ion binding]; other site 714359012032 G-X-G motif; other site 714359012033 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359012034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359012035 active site 714359012036 phosphorylation site [posttranslational modification] 714359012037 intermolecular recognition site; other site 714359012038 dimerization interface [polypeptide binding]; other site 714359012039 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359012040 DNA binding site [nucleotide binding] 714359012041 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 714359012042 active site 2 [active] 714359012043 active site 1 [active] 714359012044 malate dehydrogenase; Reviewed; Region: PRK06223 714359012045 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 714359012046 NAD(P) binding site [chemical binding]; other site 714359012047 dimer interface [polypeptide binding]; other site 714359012048 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359012049 substrate binding site [chemical binding]; other site 714359012050 isocitrate dehydrogenase; Reviewed; Region: PRK07006 714359012051 isocitrate dehydrogenase; Validated; Region: PRK07362 714359012052 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 714359012053 dimer interface [polypeptide binding]; other site 714359012054 Citrate synthase; Region: Citrate_synt; pfam00285 714359012055 active site 714359012056 citrylCoA binding site [chemical binding]; other site 714359012057 oxalacetate/citrate binding site [chemical binding]; other site 714359012058 coenzyme A binding site [chemical binding]; other site 714359012059 catalytic triad [active] 714359012060 Protein of unknown function (DUF441); Region: DUF441; pfam04284 714359012061 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 714359012062 Domain of unknown function DUF20; Region: UPF0118; pfam01594 714359012063 pyruvate kinase; Provisional; Region: PRK06354 714359012064 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 714359012065 domain interfaces; other site 714359012066 active site 714359012067 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 714359012068 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 714359012069 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 714359012070 active site 714359012071 ADP/pyrophosphate binding site [chemical binding]; other site 714359012072 dimerization interface [polypeptide binding]; other site 714359012073 allosteric effector site; other site 714359012074 fructose-1,6-bisphosphate binding site; other site 714359012075 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 714359012076 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 714359012077 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 714359012078 Transcriptional regulators [Transcription]; Region: FadR; COG2186 714359012079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359012080 DNA-binding site [nucleotide binding]; DNA binding site 714359012081 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 714359012082 Malic enzyme, N-terminal domain; Region: malic; pfam00390 714359012083 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 714359012084 putative NAD(P) binding site [chemical binding]; other site 714359012085 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 714359012086 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 714359012087 active site 714359012088 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 714359012089 generic binding surface II; other site 714359012090 generic binding surface I; other site 714359012091 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 714359012092 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 714359012093 DHH family; Region: DHH; pfam01368 714359012094 DHHA1 domain; Region: DHHA1; pfam02272 714359012095 YtpI-like protein; Region: YtpI; pfam14007 714359012096 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 714359012097 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 714359012098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359012099 DNA-binding site [nucleotide binding]; DNA binding site 714359012100 DRTGG domain; Region: DRTGG; pfam07085 714359012101 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 714359012102 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 714359012103 active site 2 [active] 714359012104 active site 1 [active] 714359012105 metal-dependent hydrolase; Provisional; Region: PRK00685 714359012106 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 714359012107 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 714359012108 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 714359012109 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 714359012110 active site 714359012111 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 714359012112 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 714359012113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359012114 Coenzyme A binding pocket [chemical binding]; other site 714359012115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359012116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359012117 Coenzyme A binding pocket [chemical binding]; other site 714359012118 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 714359012119 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 714359012120 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 714359012121 hexamer interface [polypeptide binding]; other site 714359012122 ligand binding site [chemical binding]; other site 714359012123 putative active site [active] 714359012124 NAD(P) binding site [chemical binding]; other site 714359012125 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 714359012126 classical (c) SDRs; Region: SDR_c; cd05233 714359012127 NAD(P) binding site [chemical binding]; other site 714359012128 active site 714359012129 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714359012130 Ligand Binding Site [chemical binding]; other site 714359012131 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 714359012132 argininosuccinate lyase; Provisional; Region: PRK00855 714359012133 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 714359012134 active sites [active] 714359012135 tetramer interface [polypeptide binding]; other site 714359012136 argininosuccinate synthase; Provisional; Region: PRK13820 714359012137 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 714359012138 ANP binding site [chemical binding]; other site 714359012139 Substrate Binding Site II [chemical binding]; other site 714359012140 Substrate Binding Site I [chemical binding]; other site 714359012141 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359012142 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359012143 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359012144 EcsC protein family; Region: EcsC; pfam12787 714359012145 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 714359012146 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 714359012147 nudix motif; other site 714359012148 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 714359012149 propionate/acetate kinase; Provisional; Region: PRK12379 714359012150 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 714359012151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359012152 S-adenosylmethionine binding site [chemical binding]; other site 714359012153 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 714359012154 dimer interface [polypeptide binding]; other site 714359012155 catalytic triad [active] 714359012156 peroxidatic and resolving cysteines [active] 714359012157 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 714359012158 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 714359012159 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 714359012160 ATP-NAD kinase; Region: NAD_kinase; pfam01513 714359012161 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 714359012162 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 714359012163 active site 714359012164 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359012165 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 714359012166 dimer interface [polypeptide binding]; other site 714359012167 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 714359012168 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 714359012169 active site 714359012170 acyl-activating enzyme (AAE) consensus motif; other site 714359012171 putative CoA binding site [chemical binding]; other site 714359012172 AMP binding site [chemical binding]; other site 714359012173 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359012174 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 714359012175 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 714359012176 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 714359012177 Ligand Binding Site [chemical binding]; other site 714359012178 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 714359012179 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 714359012180 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359012181 catalytic residue [active] 714359012182 septation ring formation regulator EzrA; Provisional; Region: PRK04778 714359012183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359012184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359012185 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359012186 dimerization interface [polypeptide binding]; other site 714359012187 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714359012188 EamA-like transporter family; Region: EamA; pfam00892 714359012189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359012190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359012191 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 714359012192 GAF domain; Region: GAF_2; pfam13185 714359012193 methionine gamma-lyase; Provisional; Region: PRK06767 714359012194 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 714359012195 homodimer interface [polypeptide binding]; other site 714359012196 substrate-cofactor binding pocket; other site 714359012197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359012198 catalytic residue [active] 714359012199 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 714359012200 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 714359012201 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359012202 RNA binding surface [nucleotide binding]; other site 714359012203 LXG domain of WXG superfamily; Region: LXG; pfam04740 714359012204 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 714359012205 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 714359012206 active site 714359012207 HIGH motif; other site 714359012208 dimer interface [polypeptide binding]; other site 714359012209 KMSKS motif; other site 714359012210 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359012211 RNA binding surface [nucleotide binding]; other site 714359012212 maltose O-acetyltransferase; Provisional; Region: PRK10092 714359012213 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 714359012214 active site 714359012215 substrate binding site [chemical binding]; other site 714359012216 trimer interface [polypeptide binding]; other site 714359012217 CoA binding site [chemical binding]; other site 714359012218 acetyl-CoA synthetase; Provisional; Region: PRK04319 714359012219 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 714359012220 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 714359012221 active site 714359012222 acyl-activating enzyme (AAE) consensus motif; other site 714359012223 putative CoA binding site [chemical binding]; other site 714359012224 AMP binding site [chemical binding]; other site 714359012225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 714359012226 Coenzyme A binding pocket [chemical binding]; other site 714359012227 FOG: CBS domain [General function prediction only]; Region: COG0517 714359012228 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 714359012229 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 714359012230 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 714359012231 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 714359012232 active site 714359012233 Zn binding site [ion binding]; other site 714359012234 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359012235 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359012236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359012237 active site 714359012238 phosphorylation site [posttranslational modification] 714359012239 intermolecular recognition site; other site 714359012240 dimerization interface [polypeptide binding]; other site 714359012241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359012242 DNA binding site [nucleotide binding] 714359012243 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359012244 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359012245 dimerization interface [polypeptide binding]; other site 714359012246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359012247 dimer interface [polypeptide binding]; other site 714359012248 phosphorylation site [posttranslational modification] 714359012249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359012250 ATP binding site [chemical binding]; other site 714359012251 Mg2+ binding site [ion binding]; other site 714359012252 G-X-G motif; other site 714359012253 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 714359012254 Ankyrin repeat; Region: Ank; pfam00023 714359012255 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 714359012256 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 714359012257 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 714359012258 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 714359012259 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 714359012260 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 714359012261 catabolite control protein A; Region: ccpA; TIGR01481 714359012262 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359012263 DNA binding site [nucleotide binding] 714359012264 domain linker motif; other site 714359012265 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 714359012266 dimerization interface [polypeptide binding]; other site 714359012267 effector binding site; other site 714359012268 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 714359012269 Chorismate mutase type II; Region: CM_2; cl00693 714359012270 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 714359012271 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 714359012272 putative dimer interface [polypeptide binding]; other site 714359012273 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 714359012274 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 714359012275 putative dimer interface [polypeptide binding]; other site 714359012276 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 714359012277 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 714359012278 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 714359012279 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 714359012280 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 714359012281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359012282 Coenzyme A binding pocket [chemical binding]; other site 714359012283 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359012284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 714359012285 Predicted transcriptional regulators [Transcription]; Region: COG1695 714359012286 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 714359012287 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 714359012288 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 714359012289 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 714359012290 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714359012291 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714359012292 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 714359012293 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 714359012294 active site 714359012295 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 714359012296 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 714359012297 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 714359012298 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 714359012299 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714359012300 active site 714359012301 metal binding site [ion binding]; metal-binding site 714359012302 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 714359012303 putative tRNA-binding site [nucleotide binding]; other site 714359012304 hypothetical protein; Provisional; Region: PRK13668 714359012305 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359012306 catalytic residues [active] 714359012307 NTPase; Reviewed; Region: PRK03114 714359012308 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 714359012309 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 714359012310 oligomer interface [polypeptide binding]; other site 714359012311 active site 714359012312 metal binding site [ion binding]; metal-binding site 714359012313 Predicted small secreted protein [Function unknown]; Region: COG5584 714359012314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359012315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359012316 Phosphotransferase enzyme family; Region: APH; pfam01636 714359012317 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 714359012318 active site 714359012319 substrate binding site [chemical binding]; other site 714359012320 ATP binding site [chemical binding]; other site 714359012321 pullulanase, type I; Region: pulA_typeI; TIGR02104 714359012322 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 714359012323 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 714359012324 Ca binding site [ion binding]; other site 714359012325 active site 714359012326 catalytic site [active] 714359012327 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 714359012328 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 714359012329 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 714359012330 dipeptidase PepV; Reviewed; Region: PRK07318 714359012331 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 714359012332 active site 714359012333 metal binding site [ion binding]; metal-binding site 714359012334 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 714359012335 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359012336 RNA binding surface [nucleotide binding]; other site 714359012337 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 714359012338 active site 714359012339 uracil binding [chemical binding]; other site 714359012340 stage V sporulation protein B; Region: spore_V_B; TIGR02900 714359012341 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 714359012342 HI0933-like protein; Region: HI0933_like; pfam03486 714359012343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714359012344 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359012345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359012346 putative substrate translocation pore; other site 714359012347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359012348 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359012349 dimerization interface [polypeptide binding]; other site 714359012350 putative DNA binding site [nucleotide binding]; other site 714359012351 putative Zn2+ binding site [ion binding]; other site 714359012352 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 714359012353 putative hydrophobic ligand binding site [chemical binding]; other site 714359012354 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 714359012355 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 714359012356 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 714359012357 glucose-1-dehydrogenase; Provisional; Region: PRK08936 714359012358 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 714359012359 NAD binding site [chemical binding]; other site 714359012360 homodimer interface [polypeptide binding]; other site 714359012361 active site 714359012362 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 714359012363 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 714359012364 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 714359012365 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 714359012366 MoaE interaction surface [polypeptide binding]; other site 714359012367 MoeB interaction surface [polypeptide binding]; other site 714359012368 thiocarboxylated glycine; other site 714359012369 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 714359012370 MoaE homodimer interface [polypeptide binding]; other site 714359012371 MoaD interaction [polypeptide binding]; other site 714359012372 active site residues [active] 714359012373 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 714359012374 Walker A motif; other site 714359012375 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 714359012376 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 714359012377 dimer interface [polypeptide binding]; other site 714359012378 putative functional site; other site 714359012379 putative MPT binding site; other site 714359012380 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 714359012381 trimer interface [polypeptide binding]; other site 714359012382 dimer interface [polypeptide binding]; other site 714359012383 putative active site [active] 714359012384 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 714359012385 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 714359012386 ATP binding site [chemical binding]; other site 714359012387 substrate interface [chemical binding]; other site 714359012388 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 714359012389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359012390 FeS/SAM binding site; other site 714359012391 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 714359012392 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 714359012393 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714359012394 active site residue [active] 714359012395 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 714359012396 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 714359012397 Spore germination protein; Region: Spore_permease; pfam03845 714359012398 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 714359012399 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 714359012400 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 714359012401 putative nucleotide binding site [chemical binding]; other site 714359012402 putative metal binding site [ion binding]; other site 714359012403 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 714359012404 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 714359012405 HIGH motif; other site 714359012406 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 714359012407 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 714359012408 active site 714359012409 KMSKS motif; other site 714359012410 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 714359012411 tRNA binding surface [nucleotide binding]; other site 714359012412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359012413 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359012414 putative substrate translocation pore; other site 714359012415 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 714359012416 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 714359012417 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 714359012418 TrkA-C domain; Region: TrkA_C; pfam02080 714359012419 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 714359012420 Int/Topo IB signature motif; other site 714359012421 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 714359012422 FtsX-like permease family; Region: FtsX; pfam02687 714359012423 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359012424 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714359012425 Walker A/P-loop; other site 714359012426 ATP binding site [chemical binding]; other site 714359012427 Q-loop/lid; other site 714359012428 ABC transporter signature motif; other site 714359012429 Walker B; other site 714359012430 D-loop; other site 714359012431 H-loop/switch region; other site 714359012432 Predicted membrane protein [Function unknown]; Region: COG2311 714359012433 Protein of unknown function (DUF418); Region: DUF418; cl12135 714359012434 Protein of unknown function (DUF418); Region: DUF418; pfam04235 714359012435 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 714359012436 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 714359012437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359012438 FeS/SAM binding site; other site 714359012439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359012440 S-adenosylmethionine binding site [chemical binding]; other site 714359012441 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 714359012442 aspartate racemase; Region: asp_race; TIGR00035 714359012443 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 714359012444 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 714359012445 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 714359012446 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 714359012447 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 714359012448 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 714359012449 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 714359012450 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 714359012451 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 714359012452 trimer interface [polypeptide binding]; other site 714359012453 putative metal binding site [ion binding]; other site 714359012454 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 714359012455 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 714359012456 active site 714359012457 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714359012458 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 714359012459 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 714359012460 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 714359012461 GTP binding site; other site 714359012462 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 714359012463 MPT binding site; other site 714359012464 trimer interface [polypeptide binding]; other site 714359012465 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359012466 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359012467 Coenzyme A binding pocket [chemical binding]; other site 714359012468 S-adenosylmethionine synthetase; Validated; Region: PRK05250 714359012469 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 714359012470 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 714359012471 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 714359012472 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 714359012473 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 714359012474 active site 714359012475 substrate-binding site [chemical binding]; other site 714359012476 metal-binding site [ion binding] 714359012477 ATP binding site [chemical binding]; other site 714359012478 EamA-like transporter family; Region: EamA; pfam00892 714359012479 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359012480 EamA-like transporter family; Region: EamA; pfam00892 714359012481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 714359012482 Uncharacterized conserved protein [Function unknown]; Region: COG0327 714359012483 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 714359012484 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359012485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359012486 motif II; other site 714359012487 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714359012488 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 714359012489 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714359012490 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359012491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359012492 motif II; other site 714359012493 sensor protein ZraS; Provisional; Region: PRK10364 714359012494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359012495 ATP binding site [chemical binding]; other site 714359012496 Mg2+ binding site [ion binding]; other site 714359012497 G-X-G motif; other site 714359012498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359012499 dimer interface [polypeptide binding]; other site 714359012500 phosphorylation site [posttranslational modification] 714359012501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359012502 ATP binding site [chemical binding]; other site 714359012503 Mg2+ binding site [ion binding]; other site 714359012504 G-X-G motif; other site 714359012505 hydroperoxidase II; Provisional; Region: katE; PRK11249 714359012506 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 714359012507 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 714359012508 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 714359012509 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 714359012510 Sulfatase; Region: Sulfatase; pfam00884 714359012511 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 714359012512 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 714359012513 NMT1-like family; Region: NMT1_2; pfam13379 714359012514 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 714359012515 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 714359012516 Walker A/P-loop; other site 714359012517 ATP binding site [chemical binding]; other site 714359012518 Q-loop/lid; other site 714359012519 ABC transporter signature motif; other site 714359012520 Walker B; other site 714359012521 D-loop; other site 714359012522 H-loop/switch region; other site 714359012523 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 714359012524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359012525 dimer interface [polypeptide binding]; other site 714359012526 conserved gate region; other site 714359012527 putative PBP binding loops; other site 714359012528 ABC-ATPase subunit interface; other site 714359012529 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 714359012530 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 714359012531 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 714359012532 nudix motif; other site 714359012533 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 714359012534 S-ribosylhomocysteinase; Provisional; Region: PRK02260 714359012535 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 714359012536 active site clefts [active] 714359012537 zinc binding site [ion binding]; other site 714359012538 dimer interface [polypeptide binding]; other site 714359012539 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 714359012540 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 714359012541 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 714359012542 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 714359012543 Uncharacterized conserved protein [Function unknown]; Region: COG1434 714359012544 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714359012545 putative active site [active] 714359012546 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359012547 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359012548 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359012549 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 714359012550 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 714359012551 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 714359012552 Predicted membrane protein [Function unknown]; Region: COG3766 714359012553 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 714359012554 hypothetical protein; Provisional; Region: PRK12473 714359012555 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 714359012556 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 714359012557 G1 box; other site 714359012558 GTP/Mg2+ binding site [chemical binding]; other site 714359012559 Switch I region; other site 714359012560 G2 box; other site 714359012561 G3 box; other site 714359012562 Switch II region; other site 714359012563 G4 box; other site 714359012564 G5 box; other site 714359012565 Nucleoside recognition; Region: Gate; pfam07670 714359012566 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 714359012567 Nucleoside recognition; Region: Gate; pfam07670 714359012568 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 714359012569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359012570 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359012571 dimerization interface [polypeptide binding]; other site 714359012572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359012573 dimer interface [polypeptide binding]; other site 714359012574 phosphorylation site [posttranslational modification] 714359012575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359012576 ATP binding site [chemical binding]; other site 714359012577 Mg2+ binding site [ion binding]; other site 714359012578 G-X-G motif; other site 714359012579 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359012580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359012581 active site 714359012582 phosphorylation site [posttranslational modification] 714359012583 intermolecular recognition site; other site 714359012584 dimerization interface [polypeptide binding]; other site 714359012585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359012586 DNA binding site [nucleotide binding] 714359012587 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 714359012588 active site 714359012589 catalytic site [active] 714359012590 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714359012591 active site 714359012592 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 714359012593 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 714359012594 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 714359012595 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 714359012596 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 714359012597 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 714359012598 FtsX-like permease family; Region: FtsX; pfam02687 714359012599 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359012600 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714359012601 Walker A/P-loop; other site 714359012602 ATP binding site [chemical binding]; other site 714359012603 Q-loop/lid; other site 714359012604 ABC transporter signature motif; other site 714359012605 Walker B; other site 714359012606 D-loop; other site 714359012607 H-loop/switch region; other site 714359012608 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 714359012609 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 714359012610 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714359012611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359012612 S-adenosylmethionine binding site [chemical binding]; other site 714359012613 FtsX-like permease family; Region: FtsX; pfam02687 714359012614 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359012615 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714359012616 Walker A/P-loop; other site 714359012617 ATP binding site [chemical binding]; other site 714359012618 Q-loop/lid; other site 714359012619 ABC transporter signature motif; other site 714359012620 Walker B; other site 714359012621 D-loop; other site 714359012622 H-loop/switch region; other site 714359012623 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714359012624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359012625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 714359012626 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 714359012627 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 714359012628 DNA binding residues [nucleotide binding] 714359012629 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 714359012630 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 714359012631 DNA binding residues [nucleotide binding] 714359012632 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359012633 Predicted integral membrane protein [Function unknown]; Region: COG5658 714359012634 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 714359012635 SdpI/YhfL protein family; Region: SdpI; pfam13630 714359012636 Predicted integral membrane protein [Function unknown]; Region: COG5658 714359012637 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 714359012638 SdpI/YhfL protein family; Region: SdpI; pfam13630 714359012639 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359012640 dimerization interface [polypeptide binding]; other site 714359012641 putative DNA binding site [nucleotide binding]; other site 714359012642 putative Zn2+ binding site [ion binding]; other site 714359012643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359012644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359012645 active site 714359012646 phosphorylation site [posttranslational modification] 714359012647 intermolecular recognition site; other site 714359012648 dimerization interface [polypeptide binding]; other site 714359012649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359012650 DNA binding site [nucleotide binding] 714359012651 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359012652 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 714359012653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359012654 ATP binding site [chemical binding]; other site 714359012655 Mg2+ binding site [ion binding]; other site 714359012656 G-X-G motif; other site 714359012657 FtsX-like permease family; Region: FtsX; pfam02687 714359012658 FtsX-like permease family; Region: FtsX; pfam02687 714359012659 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359012660 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714359012661 Walker A/P-loop; other site 714359012662 ATP binding site [chemical binding]; other site 714359012663 Q-loop/lid; other site 714359012664 ABC transporter signature motif; other site 714359012665 Walker B; other site 714359012666 D-loop; other site 714359012667 H-loop/switch region; other site 714359012668 GntP family permease; Region: GntP_permease; pfam02447 714359012669 fructuronate transporter; Provisional; Region: PRK10034; cl15264 714359012670 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714359012671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359012672 DNA-binding site [nucleotide binding]; DNA binding site 714359012673 UTRA domain; Region: UTRA; pfam07702 714359012674 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714359012675 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 714359012676 substrate binding site [chemical binding]; other site 714359012677 ATP binding site [chemical binding]; other site 714359012678 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 714359012679 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 714359012680 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359012681 catalytic residue [active] 714359012682 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 714359012683 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 714359012684 active site 714359012685 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 714359012686 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 714359012687 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 714359012688 dimerization interface [polypeptide binding]; other site 714359012689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359012690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359012691 dimer interface [polypeptide binding]; other site 714359012692 phosphorylation site [posttranslational modification] 714359012693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359012694 ATP binding site [chemical binding]; other site 714359012695 Mg2+ binding site [ion binding]; other site 714359012696 G-X-G motif; other site 714359012697 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359012698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359012699 active site 714359012700 phosphorylation site [posttranslational modification] 714359012701 intermolecular recognition site; other site 714359012702 dimerization interface [polypeptide binding]; other site 714359012703 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359012704 DNA binding site [nucleotide binding] 714359012705 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 714359012706 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 714359012707 active site 714359012708 octamer interface [polypeptide binding]; other site 714359012709 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 714359012710 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 714359012711 acyl-activating enzyme (AAE) consensus motif; other site 714359012712 putative AMP binding site [chemical binding]; other site 714359012713 putative active site [active] 714359012714 putative CoA binding site [chemical binding]; other site 714359012715 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714359012716 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 714359012717 substrate binding site [chemical binding]; other site 714359012718 oxyanion hole (OAH) forming residues; other site 714359012719 trimer interface [polypeptide binding]; other site 714359012720 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 714359012721 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 714359012722 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 714359012723 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 714359012724 dimer interface [polypeptide binding]; other site 714359012725 tetramer interface [polypeptide binding]; other site 714359012726 PYR/PP interface [polypeptide binding]; other site 714359012727 TPP binding site [chemical binding]; other site 714359012728 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 714359012729 TPP-binding site; other site 714359012730 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 714359012731 chorismate binding enzyme; Region: Chorismate_bind; cl10555 714359012732 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 714359012733 UbiA prenyltransferase family; Region: UbiA; pfam01040 714359012734 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 714359012735 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714359012736 DNA-binding site [nucleotide binding]; DNA binding site 714359012737 RNA-binding motif; other site 714359012738 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 714359012739 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 714359012740 active site flap/lid [active] 714359012741 nucleophilic elbow; other site 714359012742 catalytic triad [active] 714359012743 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 714359012744 homodimer interface [polypeptide binding]; other site 714359012745 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 714359012746 active site pocket [active] 714359012747 glycogen synthase; Provisional; Region: glgA; PRK00654 714359012748 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 714359012749 ADP-binding pocket [chemical binding]; other site 714359012750 homodimer interface [polypeptide binding]; other site 714359012751 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 714359012752 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 714359012753 ligand binding site; other site 714359012754 oligomer interface; other site 714359012755 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 714359012756 dimer interface [polypeptide binding]; other site 714359012757 N-terminal domain interface [polypeptide binding]; other site 714359012758 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 714359012759 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 714359012760 ligand binding site; other site 714359012761 oligomer interface; other site 714359012762 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 714359012763 dimer interface [polypeptide binding]; other site 714359012764 N-terminal domain interface [polypeptide binding]; other site 714359012765 sulfate 1 binding site; other site 714359012766 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 714359012767 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 714359012768 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 714359012769 active site 714359012770 catalytic site [active] 714359012771 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 714359012772 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 714359012773 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 714359012774 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 714359012775 putative active site [active] 714359012776 catalytic triad [active] 714359012777 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 714359012778 PA/protease domain interface [polypeptide binding]; other site 714359012779 putative integrin binding motif; other site 714359012780 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 714359012781 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 714359012782 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 714359012783 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 714359012784 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359012785 NAD binding site [chemical binding]; other site 714359012786 dimer interface [polypeptide binding]; other site 714359012787 substrate binding site [chemical binding]; other site 714359012788 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 714359012789 MgtC family; Region: MgtC; pfam02308 714359012790 Ion channel; Region: Ion_trans_2; pfam07885 714359012791 TrkA-N domain; Region: TrkA_N; pfam02254 714359012792 YugN-like family; Region: YugN; pfam08868 714359012793 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 714359012794 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 714359012795 dimer interface [polypeptide binding]; other site 714359012796 active site 714359012797 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 714359012798 dimer interface [polypeptide binding]; other site 714359012799 active site 714359012800 Domain of unknown function (DUF378); Region: DUF378; pfam04070 714359012801 general stress protein 13; Validated; Region: PRK08059 714359012802 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 714359012803 RNA binding site [nucleotide binding]; other site 714359012804 hypothetical protein; Validated; Region: PRK07682 714359012805 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359012806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359012807 homodimer interface [polypeptide binding]; other site 714359012808 catalytic residue [active] 714359012809 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 714359012810 AsnC family; Region: AsnC_trans_reg; pfam01037 714359012811 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 714359012812 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 714359012813 dimerization interface [polypeptide binding]; other site 714359012814 ligand binding site [chemical binding]; other site 714359012815 NADP binding site [chemical binding]; other site 714359012816 catalytic site [active] 714359012817 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 714359012818 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359012819 nucleophilic elbow; other site 714359012820 catalytic triad; other site 714359012821 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 714359012822 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 714359012823 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359012824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359012825 homodimer interface [polypeptide binding]; other site 714359012826 catalytic residue [active] 714359012827 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 714359012828 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 714359012829 E-class dimer interface [polypeptide binding]; other site 714359012830 P-class dimer interface [polypeptide binding]; other site 714359012831 active site 714359012832 Cu2+ binding site [ion binding]; other site 714359012833 Zn2+ binding site [ion binding]; other site 714359012834 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 714359012835 Kinase associated protein B; Region: KapB; pfam08810 714359012836 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 714359012837 active site 714359012838 catalytic site [active] 714359012839 substrate binding site [chemical binding]; other site 714359012840 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 714359012841 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 714359012842 transmembrane helices; other site 714359012843 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 714359012844 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 714359012845 active site 714359012846 glycyl-tRNA synthetase; Provisional; Region: PRK04173 714359012847 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 714359012848 motif 1; other site 714359012849 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 714359012850 active site 714359012851 motif 2; other site 714359012852 motif 3; other site 714359012853 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 714359012854 anticodon binding site; other site 714359012855 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 714359012856 CoenzymeA binding site [chemical binding]; other site 714359012857 subunit interaction site [polypeptide binding]; other site 714359012858 PHB binding site; other site 714359012859 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 714359012860 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 714359012861 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 714359012862 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 714359012863 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 714359012864 active site 714359012865 tetramer interface; other site 714359012866 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 714359012867 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 714359012868 active site 714359012869 substrate binding site [chemical binding]; other site 714359012870 metal binding site [ion binding]; metal-binding site 714359012871 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 714359012872 Uncharacterized conserved protein [Function unknown]; Region: COG1624 714359012873 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 714359012874 multifunctional aminopeptidase A; Provisional; Region: PRK00913 714359012875 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 714359012876 interface (dimer of trimers) [polypeptide binding]; other site 714359012877 Substrate-binding/catalytic site; other site 714359012878 Zn-binding sites [ion binding]; other site 714359012879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 714359012880 Putative membrane protein; Region: YuiB; pfam14068 714359012881 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 714359012882 nudix motif; other site 714359012883 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 714359012884 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714359012885 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 714359012886 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714359012887 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714359012888 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 714359012889 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359012890 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359012891 Domain of unknown function DUF11; Region: DUF11; pfam01345 714359012892 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359012893 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359012894 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359012895 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359012896 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359012897 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359012898 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359012899 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359012900 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359012901 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359012902 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359012903 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359012904 Domain of unknown function DUF11; Region: DUF11; pfam01345 714359012905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 714359012906 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359012907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359012908 putative substrate translocation pore; other site 714359012909 Helix-turn-helix domain; Region: HTH_36; pfam13730 714359012910 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 714359012911 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 714359012912 putative DNA binding site [nucleotide binding]; other site 714359012913 dimerization interface [polypeptide binding]; other site 714359012914 Protein of unknown function (DUF523); Region: DUF523; pfam04463 714359012915 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 714359012916 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 714359012917 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 714359012918 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 714359012919 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 714359012920 hypothetical protein; Provisional; Region: PRK13669 714359012921 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 714359012922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714359012923 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 714359012924 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359012925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359012926 Walker A/P-loop; other site 714359012927 ATP binding site [chemical binding]; other site 714359012928 Q-loop/lid; other site 714359012929 ABC transporter signature motif; other site 714359012930 Walker B; other site 714359012931 D-loop; other site 714359012932 H-loop/switch region; other site 714359012933 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 714359012934 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 714359012935 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 714359012936 PhnA protein; Region: PhnA; pfam03831 714359012937 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 714359012938 CAAX protease self-immunity; Region: Abi; pfam02517 714359012939 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 714359012940 active site 714359012941 NTP binding site [chemical binding]; other site 714359012942 metal binding triad [ion binding]; metal-binding site 714359012943 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 714359012944 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 714359012945 NifU-like domain; Region: NifU; pfam01106 714359012946 spore coat protein YutH; Region: spore_yutH; TIGR02905 714359012947 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 714359012948 tetramer interfaces [polypeptide binding]; other site 714359012949 binuclear metal-binding site [ion binding]; other site 714359012950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359012951 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359012952 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 714359012953 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 714359012954 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 714359012955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359012956 active site 714359012957 motif I; other site 714359012958 motif II; other site 714359012959 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359012960 Predicted transcriptional regulator [Transcription]; Region: COG2345 714359012961 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359012962 putative Zn2+ binding site [ion binding]; other site 714359012963 putative DNA binding site [nucleotide binding]; other site 714359012964 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 714359012965 Uncharacterized conserved protein [Function unknown]; Region: COG2445 714359012966 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 714359012967 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 714359012968 putative active site [active] 714359012969 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 714359012970 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 714359012971 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 714359012972 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 714359012973 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 714359012974 DNA binding residues [nucleotide binding] 714359012975 dimer interface [polypeptide binding]; other site 714359012976 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 714359012977 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 714359012978 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359012979 catalytic core [active] 714359012980 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 714359012981 lipoyl synthase; Provisional; Region: PRK05481 714359012982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359012983 FeS/SAM binding site; other site 714359012984 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 714359012985 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359012986 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 714359012987 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 714359012988 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714359012989 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 714359012990 active site 714359012991 metal binding site [ion binding]; metal-binding site 714359012992 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714359012993 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 714359012994 FeS assembly protein SufB; Region: sufB; TIGR01980 714359012995 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 714359012996 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 714359012997 trimerization site [polypeptide binding]; other site 714359012998 active site 714359012999 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 714359013000 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 714359013001 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359013002 catalytic residue [active] 714359013003 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 714359013004 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 714359013005 FeS assembly protein SufD; Region: sufD; TIGR01981 714359013006 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 714359013007 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 714359013008 Walker A/P-loop; other site 714359013009 ATP binding site [chemical binding]; other site 714359013010 Q-loop/lid; other site 714359013011 ABC transporter signature motif; other site 714359013012 Walker B; other site 714359013013 D-loop; other site 714359013014 H-loop/switch region; other site 714359013015 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 714359013016 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 714359013017 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 714359013018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359013019 ABC-ATPase subunit interface; other site 714359013020 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 714359013021 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 714359013022 Walker A/P-loop; other site 714359013023 ATP binding site [chemical binding]; other site 714359013024 Q-loop/lid; other site 714359013025 ABC transporter signature motif; other site 714359013026 Walker B; other site 714359013027 D-loop; other site 714359013028 H-loop/switch region; other site 714359013029 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 714359013030 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359013031 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 714359013032 putative active site [active] 714359013033 putative metal binding site [ion binding]; other site 714359013034 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 714359013035 lipoyl attachment site [posttranslational modification]; other site 714359013036 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 714359013037 ArsC family; Region: ArsC; pfam03960 714359013038 putative ArsC-like catalytic residues; other site 714359013039 putative TRX-like catalytic residues [active] 714359013040 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 714359013041 active site 714359013042 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 714359013043 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 714359013044 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 714359013045 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 714359013046 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359013047 NAD binding site [chemical binding]; other site 714359013048 dimer interface [polypeptide binding]; other site 714359013049 substrate binding site [chemical binding]; other site 714359013050 Coat F domain; Region: Coat_F; pfam07875 714359013051 CAAX protease self-immunity; Region: Abi; pfam02517 714359013052 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359013053 WHG domain; Region: WHG; pfam13305 714359013054 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714359013055 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 714359013056 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 714359013057 active site 714359013058 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 714359013059 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 714359013060 dimer interface [polypeptide binding]; other site 714359013061 active site 714359013062 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 714359013063 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 714359013064 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 714359013065 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 714359013066 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714359013067 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 714359013068 substrate binding site [chemical binding]; other site 714359013069 oxyanion hole (OAH) forming residues; other site 714359013070 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714359013071 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 714359013072 Proline dehydrogenase; Region: Pro_dh; cl03282 714359013073 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 714359013074 Domain of unknown function DUF77; Region: DUF77; pfam01910 714359013075 Cache domain; Region: Cache_1; pfam02743 714359013076 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359013077 dimerization interface [polypeptide binding]; other site 714359013078 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359013079 dimer interface [polypeptide binding]; other site 714359013080 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359013081 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359013082 dimer interface [polypeptide binding]; other site 714359013083 putative CheW interface [polypeptide binding]; other site 714359013084 Predicted transcriptional regulators [Transcription]; Region: COG1378 714359013085 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 714359013086 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 714359013087 C-terminal domain interface [polypeptide binding]; other site 714359013088 sugar binding site [chemical binding]; other site 714359013089 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 714359013090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359013091 putative substrate translocation pore; other site 714359013092 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 714359013093 L-type amino acid transporter; Region: 2A0308; TIGR00911 714359013094 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 714359013095 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714359013096 OxaA-like protein precursor; Validated; Region: PRK01622 714359013097 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359013098 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359013099 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 714359013100 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714359013101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 714359013102 hypothetical protein; Provisional; Region: PRK06758 714359013103 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 714359013104 active site 714359013105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359013106 non-specific DNA binding site [nucleotide binding]; other site 714359013107 salt bridge; other site 714359013108 sequence-specific DNA binding site [nucleotide binding]; other site 714359013109 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714359013110 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 714359013111 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 714359013112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 714359013113 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 714359013114 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359013115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359013116 active site 714359013117 phosphorylation site [posttranslational modification] 714359013118 intermolecular recognition site; other site 714359013119 dimerization interface [polypeptide binding]; other site 714359013120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359013121 DNA binding site [nucleotide binding] 714359013122 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359013123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359013124 dimer interface [polypeptide binding]; other site 714359013125 phosphorylation site [posttranslational modification] 714359013126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359013127 ATP binding site [chemical binding]; other site 714359013128 Mg2+ binding site [ion binding]; other site 714359013129 G-X-G motif; other site 714359013130 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714359013131 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 714359013132 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 714359013133 active site 714359013134 HIGH motif; other site 714359013135 KMSKS motif; other site 714359013136 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 714359013137 tRNA binding surface [nucleotide binding]; other site 714359013138 anticodon binding site; other site 714359013139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359013140 S-adenosylmethionine binding site [chemical binding]; other site 714359013141 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359013142 dimerization interface [polypeptide binding]; other site 714359013143 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359013144 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359013145 dimer interface [polypeptide binding]; other site 714359013146 putative CheW interface [polypeptide binding]; other site 714359013147 CHASE3 domain; Region: CHASE3; cl05000 714359013148 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 714359013149 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359013150 dimerization interface [polypeptide binding]; other site 714359013151 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359013152 dimer interface [polypeptide binding]; other site 714359013153 putative CheW interface [polypeptide binding]; other site 714359013154 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 714359013155 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359013156 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359013157 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 714359013158 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 714359013159 active site 714359013160 Zn binding site [ion binding]; other site 714359013161 Pirin-related protein [General function prediction only]; Region: COG1741 714359013162 Pirin; Region: Pirin; pfam02678 714359013163 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 714359013164 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359013165 MarR family; Region: MarR_2; pfam12802 714359013166 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 714359013167 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714359013168 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 714359013169 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 714359013170 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 714359013171 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 714359013172 TrkA-C domain; Region: TrkA_C; pfam02080 714359013173 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 714359013174 amino acid carrier protein; Region: agcS; TIGR00835 714359013175 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 714359013176 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 714359013177 dimerization interface [polypeptide binding]; other site 714359013178 DPS ferroxidase diiron center [ion binding]; other site 714359013179 ion pore; other site 714359013180 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 714359013181 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 714359013182 metal binding site [ion binding]; metal-binding site 714359013183 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 714359013184 Ferritin-like domain; Region: Ferritin; pfam00210 714359013185 ferroxidase diiron center [ion binding]; other site 714359013186 Predicted membrane protein [Function unknown]; Region: COG2311 714359013187 Protein of unknown function (DUF418); Region: DUF418; cl12135 714359013188 Protein of unknown function (DUF418); Region: DUF418; pfam04235 714359013189 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714359013190 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714359013191 Nucleoside recognition; Region: Gate; pfam07670 714359013192 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359013193 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714359013194 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714359013195 Nucleoside recognition; Region: Gate; pfam07670 714359013196 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359013197 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 714359013198 amino acid carrier protein; Region: agcS; TIGR00835 714359013199 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 714359013200 amino acid carrier protein; Region: agcS; TIGR00835 714359013201 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 714359013202 NADH(P)-binding; Region: NAD_binding_10; pfam13460 714359013203 NAD binding site [chemical binding]; other site 714359013204 substrate binding site [chemical binding]; other site 714359013205 putative active site [active] 714359013206 Peptidase M60-like family; Region: M60-like; pfam13402 714359013207 TQXA domain; Region: TQXA_dom; TIGR03934 714359013208 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359013209 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714359013210 active site 714359013211 catalytic tetrad [active] 714359013212 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 714359013213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359013214 putative substrate translocation pore; other site 714359013215 Predicted transcriptional regulators [Transcription]; Region: COG1733 714359013216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359013217 dimerization interface [polypeptide binding]; other site 714359013218 putative DNA binding site [nucleotide binding]; other site 714359013219 putative Zn2+ binding site [ion binding]; other site 714359013220 Uncharacterized conserved protein [Function unknown]; Region: COG2427 714359013221 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 714359013222 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714359013223 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 714359013224 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 714359013225 active site 714359013226 HIGH motif; other site 714359013227 dimer interface [polypeptide binding]; other site 714359013228 KMSKS motif; other site 714359013229 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359013230 RNA binding surface [nucleotide binding]; other site 714359013231 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 714359013232 FAD binding domain; Region: FAD_binding_4; pfam01565 714359013233 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 714359013234 SET domain; Region: SET; pfam00856 714359013235 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 714359013236 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359013237 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359013238 dimer interface [polypeptide binding]; other site 714359013239 putative CheW interface [polypeptide binding]; other site 714359013240 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 714359013241 putative phosphate binding site [ion binding]; other site 714359013242 camphor resistance protein CrcB; Provisional; Region: PRK14205 714359013243 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 714359013244 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 714359013245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359013246 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359013247 putative substrate translocation pore; other site 714359013248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359013249 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359013250 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359013251 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359013252 ABC transporter; Region: ABC_tran_2; pfam12848 714359013253 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359013254 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359013255 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714359013256 Coenzyme A binding pocket [chemical binding]; other site 714359013257 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 714359013258 Nuclease-related domain; Region: NERD; pfam08378 714359013259 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 714359013260 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 714359013261 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 714359013262 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714359013263 Walker A/P-loop; other site 714359013264 ATP binding site [chemical binding]; other site 714359013265 Q-loop/lid; other site 714359013266 ABC transporter signature motif; other site 714359013267 Walker B; other site 714359013268 D-loop; other site 714359013269 H-loop/switch region; other site 714359013270 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359013271 ABC-ATPase subunit interface; other site 714359013272 dimer interface [polypeptide binding]; other site 714359013273 putative PBP binding regions; other site 714359013274 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714359013275 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359013276 ABC-ATPase subunit interface; other site 714359013277 dimer interface [polypeptide binding]; other site 714359013278 putative PBP binding regions; other site 714359013279 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 714359013280 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 714359013281 putative ligand binding residues [chemical binding]; other site 714359013282 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359013283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359013284 active site 714359013285 phosphorylation site [posttranslational modification] 714359013286 intermolecular recognition site; other site 714359013287 dimerization interface [polypeptide binding]; other site 714359013288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359013289 DNA binding site [nucleotide binding] 714359013290 Z1 domain; Region: Z1; pfam10593 714359013291 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 714359013292 SmpB-tmRNA interface; other site 714359013293 ribonuclease R; Region: RNase_R; TIGR02063 714359013294 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 714359013295 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 714359013296 RNB domain; Region: RNB; pfam00773 714359013297 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 714359013298 RNA binding site [nucleotide binding]; other site 714359013299 Esterase/lipase [General function prediction only]; Region: COG1647 714359013300 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 714359013301 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 714359013302 holin-like protein; Validated; Region: PRK01658 714359013303 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 714359013304 active site 714359013305 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 714359013306 Phage terminase, small subunit; Region: Terminase_4; pfam05119 714359013307 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 714359013308 Phage-related protein [Function unknown]; Region: COG4695; cl01923 714359013309 Phage portal protein; Region: Phage_portal; pfam04860 714359013310 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 714359013311 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 714359013312 Phage capsid family; Region: Phage_capsid; pfam05065 714359013313 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714359013314 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 714359013315 active site 714359013316 DNA binding site [nucleotide binding] 714359013317 Int/Topo IB signature motif; other site 714359013318 enolase; Provisional; Region: eno; PRK00077 714359013319 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 714359013320 dimer interface [polypeptide binding]; other site 714359013321 metal binding site [ion binding]; metal-binding site 714359013322 substrate binding pocket [chemical binding]; other site 714359013323 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 714359013324 phosphoglyceromutase; Provisional; Region: PRK05434 714359013325 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 714359013326 triosephosphate isomerase; Provisional; Region: PRK14565 714359013327 substrate binding site [chemical binding]; other site 714359013328 dimer interface [polypeptide binding]; other site 714359013329 catalytic triad [active] 714359013330 Phosphoglycerate kinase; Region: PGK; pfam00162 714359013331 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 714359013332 substrate binding site [chemical binding]; other site 714359013333 hinge regions; other site 714359013334 ADP binding site [chemical binding]; other site 714359013335 catalytic site [active] 714359013336 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 714359013337 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 714359013338 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 714359013339 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 714359013340 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 714359013341 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 714359013342 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 714359013343 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 714359013344 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 714359013345 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 714359013346 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 714359013347 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 714359013348 stage V sporulation protein AD; Provisional; Region: PRK12404 714359013349 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 714359013350 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 714359013351 Predicted membrane protein [Function unknown]; Region: COG2323 714359013352 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 714359013353 Clp protease; Region: CLP_protease; pfam00574 714359013354 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 714359013355 oligomer interface [polypeptide binding]; other site 714359013356 active site residues [active] 714359013357 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 714359013358 dimerization domain swap beta strand [polypeptide binding]; other site 714359013359 regulatory protein interface [polypeptide binding]; other site 714359013360 active site 714359013361 regulatory phosphorylation site [posttranslational modification]; other site 714359013362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 714359013363 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 714359013364 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 714359013365 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 714359013366 phosphate binding site [ion binding]; other site 714359013367 putative substrate binding pocket [chemical binding]; other site 714359013368 dimer interface [polypeptide binding]; other site 714359013369 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 714359013370 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 714359013371 nudix motif; other site 714359013372 Domain of unknown function (DUF368); Region: DUF368; pfam04018 714359013373 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 714359013374 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714359013375 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714359013376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359013377 TPR motif; other site 714359013378 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359013379 binding surface 714359013380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359013381 binding surface 714359013382 Tetratricopeptide repeat; Region: TPR_16; pfam13432 714359013383 TPR motif; other site 714359013384 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 714359013385 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 714359013386 trimer interface [polypeptide binding]; other site 714359013387 active site 714359013388 substrate binding site [chemical binding]; other site 714359013389 CoA binding site [chemical binding]; other site 714359013390 pyrophosphatase PpaX; Provisional; Region: PRK13288 714359013391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359013392 active site 714359013393 motif I; other site 714359013394 motif II; other site 714359013395 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 714359013396 HPr kinase/phosphorylase; Provisional; Region: PRK05428 714359013397 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 714359013398 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 714359013399 Hpr binding site; other site 714359013400 active site 714359013401 homohexamer subunit interaction site [polypeptide binding]; other site 714359013402 Predicted membrane protein [Function unknown]; Region: COG1950 714359013403 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 714359013404 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 714359013405 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 714359013406 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 714359013407 excinuclease ABC subunit B; Provisional; Region: PRK05298 714359013408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359013409 ATP binding site [chemical binding]; other site 714359013410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359013411 nucleotide binding region [chemical binding]; other site 714359013412 ATP-binding site [chemical binding]; other site 714359013413 Ultra-violet resistance protein B; Region: UvrB; pfam12344 714359013414 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 714359013415 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 714359013416 DNA binding residues [nucleotide binding] 714359013417 dimer interface [polypeptide binding]; other site 714359013418 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 714359013419 Predicted membrane protein [Function unknown]; Region: COG2855 714359013420 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359013421 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359013422 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 714359013423 putative dimerization interface [polypeptide binding]; other site 714359013424 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 714359013425 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 714359013426 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359013427 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359013428 ABC transporter; Region: ABC_tran_2; pfam12848 714359013429 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359013430 hypothetical protein; Provisional; Region: PRK12855 714359013431 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714359013432 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359013433 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 714359013434 Walker A/P-loop; other site 714359013435 ATP binding site [chemical binding]; other site 714359013436 Q-loop/lid; other site 714359013437 ABC transporter signature motif; other site 714359013438 Walker B; other site 714359013439 D-loop; other site 714359013440 H-loop/switch region; other site 714359013441 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 714359013442 protein binding site [polypeptide binding]; other site 714359013443 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 714359013444 C-terminal peptidase (prc); Region: prc; TIGR00225 714359013445 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 714359013446 protein binding site [polypeptide binding]; other site 714359013447 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 714359013448 Catalytic dyad [active] 714359013449 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 714359013450 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 714359013451 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 714359013452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359013453 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 714359013454 Walker A/P-loop; other site 714359013455 ATP binding site [chemical binding]; other site 714359013456 Q-loop/lid; other site 714359013457 ABC transporter signature motif; other site 714359013458 Walker B; other site 714359013459 D-loop; other site 714359013460 H-loop/switch region; other site 714359013461 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 714359013462 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 714359013463 peptide chain release factor 2; Provisional; Region: PRK06746 714359013464 This domain is found in peptide chain release factors; Region: PCRF; smart00937 714359013465 RF-1 domain; Region: RF-1; pfam00472 714359013466 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 714359013467 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 714359013468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 714359013469 nucleotide binding region [chemical binding]; other site 714359013470 ATP-binding site [chemical binding]; other site 714359013471 SEC-C motif; Region: SEC-C; pfam02810 714359013472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359013473 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714359013474 Walker A/P-loop; other site 714359013475 ATP binding site [chemical binding]; other site 714359013476 Q-loop/lid; other site 714359013477 ABC transporter signature motif; other site 714359013478 Walker B; other site 714359013479 D-loop; other site 714359013480 H-loop/switch region; other site 714359013481 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 714359013482 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 714359013483 30S subunit binding site; other site 714359013484 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714359013485 DNA-binding site [nucleotide binding]; DNA binding site 714359013486 RNA-binding motif; other site 714359013487 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 714359013488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714359013489 active site 714359013490 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 714359013491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359013492 ATP binding site [chemical binding]; other site 714359013493 putative Mg++ binding site [ion binding]; other site 714359013494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359013495 nucleotide binding region [chemical binding]; other site 714359013496 ATP-binding site [chemical binding]; other site 714359013497 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 714359013498 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 714359013499 NlpC/P60 family; Region: NLPC_P60; pfam00877 714359013500 Predicted transcriptional regulators [Transcription]; Region: COG1733 714359013501 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 714359013502 EDD domain protein, DegV family; Region: DegV; TIGR00762 714359013503 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 714359013504 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 714359013505 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 714359013506 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 714359013507 Transcriptional regulator [Transcription]; Region: LytR; COG1316 714359013508 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 714359013509 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 714359013510 active site 714359013511 homodimer interface [polypeptide binding]; other site 714359013512 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 714359013513 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 714359013514 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 714359013515 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 714359013516 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 714359013517 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 714359013518 Mg++ binding site [ion binding]; other site 714359013519 putative catalytic motif [active] 714359013520 substrate binding site [chemical binding]; other site 714359013521 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 714359013522 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 714359013523 NodB motif; other site 714359013524 active site 714359013525 catalytic site [active] 714359013526 Zn binding site [ion binding]; other site 714359013527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359013528 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 714359013529 Walker A motif; other site 714359013530 ATP binding site [chemical binding]; other site 714359013531 Walker B motif; other site 714359013532 arginine finger; other site 714359013533 Transcriptional antiterminator [Transcription]; Region: COG3933 714359013534 PRD domain; Region: PRD; pfam00874 714359013535 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 714359013536 active pocket/dimerization site; other site 714359013537 active site 714359013538 phosphorylation site [posttranslational modification] 714359013539 PRD domain; Region: PRD; pfam00874 714359013540 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 714359013541 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 714359013542 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 714359013543 Chromate transporter; Region: Chromate_transp; pfam02417 714359013544 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 714359013545 putative active site [active] 714359013546 YdjC motif; other site 714359013547 Mg binding site [ion binding]; other site 714359013548 putative homodimer interface [polypeptide binding]; other site 714359013549 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 714359013550 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 714359013551 NAD binding site [chemical binding]; other site 714359013552 sugar binding site [chemical binding]; other site 714359013553 divalent metal binding site [ion binding]; other site 714359013554 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359013555 dimer interface [polypeptide binding]; other site 714359013556 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 714359013557 active site 714359013558 methionine cluster; other site 714359013559 phosphorylation site [posttranslational modification] 714359013560 metal binding site [ion binding]; metal-binding site 714359013561 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 714359013562 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 714359013563 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 714359013564 active site 714359013565 P-loop; other site 714359013566 phosphorylation site [posttranslational modification] 714359013567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359013568 S-adenosylmethionine binding site [chemical binding]; other site 714359013569 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 714359013570 methionine cluster; other site 714359013571 active site 714359013572 phosphorylation site [posttranslational modification] 714359013573 metal binding site [ion binding]; metal-binding site 714359013574 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 714359013575 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 714359013576 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 714359013577 active site 714359013578 P-loop; other site 714359013579 phosphorylation site [posttranslational modification] 714359013580 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 714359013581 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 714359013582 Acyltransferase family; Region: Acyl_transf_3; pfam01757 714359013583 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 714359013584 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 714359013585 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359013586 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 714359013587 active site 714359013588 catalytic site [active] 714359013589 Cna protein B-type domain; Region: Cna_B; pfam05738 714359013590 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359013591 Cna protein B-type domain; Region: Cna_B; pfam05738 714359013592 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 714359013593 Domain of unknown function DUF11; Region: DUF11; pfam01345 714359013594 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359013595 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359013596 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 714359013597 Cna protein B-type domain; Region: Cna_B; pfam05738 714359013598 Predicted membrane protein [Function unknown]; Region: COG1511 714359013599 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 714359013600 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 714359013601 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 714359013602 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 714359013603 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359013604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714359013605 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 714359013606 putative dimerization interface [polypeptide binding]; other site 714359013607 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 714359013608 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 714359013609 arsenical pump membrane protein; Provisional; Region: PRK15445 714359013610 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 714359013611 transmembrane helices; other site 714359013612 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 714359013613 ThiC-associated domain; Region: ThiC-associated; pfam13667 714359013614 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 714359013615 L-lactate permease; Region: Lactate_perm; cl00701 714359013616 glycolate transporter; Provisional; Region: PRK09695 714359013617 Tic20-like protein; Region: Tic20; pfam09685 714359013618 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 714359013619 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 714359013620 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 714359013621 Sulfatase; Region: Sulfatase; pfam00884 714359013622 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 714359013623 homodimer interface [polypeptide binding]; other site 714359013624 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 714359013625 substrate-cofactor binding pocket; other site 714359013626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359013627 catalytic residue [active] 714359013628 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359013629 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359013630 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359013631 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359013632 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359013633 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 714359013634 NlpC/P60 family; Region: NLPC_P60; pfam00877 714359013635 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714359013636 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714359013637 Nucleoside recognition; Region: Gate; pfam07670 714359013638 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359013639 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 714359013640 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 714359013641 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 714359013642 DXD motif; other site 714359013643 BCCT family transporter; Region: BCCT; pfam02028 714359013644 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359013645 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359013646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 714359013647 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 714359013648 Predicted membrane protein [Function unknown]; Region: COG4640 714359013649 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 714359013650 Double zinc ribbon; Region: DZR; pfam12773 714359013651 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 714359013652 Double zinc ribbon; Region: DZR; pfam12773 714359013653 SNF2 Helicase protein; Region: DUF3670; pfam12419 714359013654 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 714359013655 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359013656 ATP binding site [chemical binding]; other site 714359013657 putative Mg++ binding site [ion binding]; other site 714359013658 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359013659 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 714359013660 nucleotide binding region [chemical binding]; other site 714359013661 ATP-binding site [chemical binding]; other site 714359013662 Predicted integral membrane protein [Function unknown]; Region: COG5652 714359013663 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 714359013664 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 714359013665 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 714359013666 ComK protein; Region: ComK; cl11560 714359013667 RNA polymerase factor sigma-70; Validated; Region: PRK06759 714359013668 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359013669 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359013670 DNA binding residues [nucleotide binding] 714359013671 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 714359013672 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 714359013673 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 714359013674 FtsX-like permease family; Region: FtsX; pfam02687 714359013675 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714359013676 ABC transporter; Region: ABC_tran; pfam00005 714359013677 Q-loop/lid; other site 714359013678 ABC transporter signature motif; other site 714359013679 Walker B; other site 714359013680 D-loop; other site 714359013681 H-loop/switch region; other site 714359013682 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 714359013683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714359013684 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 714359013685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359013686 putative substrate translocation pore; other site 714359013687 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 714359013688 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 714359013689 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 714359013690 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 714359013691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359013692 dimerization interface [polypeptide binding]; other site 714359013693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359013694 dimer interface [polypeptide binding]; other site 714359013695 phosphorylation site [posttranslational modification] 714359013696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359013697 ATP binding site [chemical binding]; other site 714359013698 Mg2+ binding site [ion binding]; other site 714359013699 G-X-G motif; other site 714359013700 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359013701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359013702 active site 714359013703 phosphorylation site [posttranslational modification] 714359013704 intermolecular recognition site; other site 714359013705 dimerization interface [polypeptide binding]; other site 714359013706 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359013707 DNA binding site [nucleotide binding] 714359013708 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 714359013709 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 714359013710 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714359013711 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 714359013712 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 714359013713 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714359013714 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 714359013715 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 714359013716 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 714359013717 trimer interface [polypeptide binding]; other site 714359013718 active site 714359013719 substrate binding site [chemical binding]; other site 714359013720 CoA binding site [chemical binding]; other site 714359013721 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 714359013722 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 714359013723 NAD binding site [chemical binding]; other site 714359013724 substrate binding site [chemical binding]; other site 714359013725 homodimer interface [polypeptide binding]; other site 714359013726 active site 714359013727 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 714359013728 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 714359013729 NADP binding site [chemical binding]; other site 714359013730 active site 714359013731 putative substrate binding site [chemical binding]; other site 714359013732 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 714359013733 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 714359013734 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 714359013735 substrate binding site; other site 714359013736 tetramer interface; other site 714359013737 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 714359013738 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 714359013739 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 714359013740 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 714359013741 Probable Catalytic site; other site 714359013742 metal-binding site 714359013743 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714359013744 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 714359013745 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 714359013746 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 714359013747 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 714359013748 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 714359013749 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359013750 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 714359013751 active site 714359013752 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 714359013753 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 714359013754 Probable Catalytic site; other site 714359013755 metal-binding site 714359013756 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 714359013757 Bacterial sugar transferase; Region: Bac_transf; pfam02397 714359013758 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 714359013759 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 714359013760 active site 714359013761 tetramer interface; other site 714359013762 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 714359013763 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 714359013764 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 714359013765 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 714359013766 Chain length determinant protein; Region: Wzz; cl15801 714359013767 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 714359013768 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 714359013769 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 714359013770 rod shape-determining protein Mbl; Provisional; Region: PRK13928 714359013771 MreB and similar proteins; Region: MreB_like; cd10225 714359013772 nucleotide binding site [chemical binding]; other site 714359013773 Mg binding site [ion binding]; other site 714359013774 putative protofilament interaction site [polypeptide binding]; other site 714359013775 RodZ interaction site [polypeptide binding]; other site 714359013776 Stage III sporulation protein D; Region: SpoIIID; pfam12116 714359013777 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 714359013778 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359013779 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 714359013780 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 714359013781 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359013782 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714359013783 Walker A/P-loop; other site 714359013784 ATP binding site [chemical binding]; other site 714359013785 Q-loop/lid; other site 714359013786 ABC transporter signature motif; other site 714359013787 Walker B; other site 714359013788 D-loop; other site 714359013789 H-loop/switch region; other site 714359013790 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714359013791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359013792 Q-loop/lid; other site 714359013793 ABC transporter signature motif; other site 714359013794 Walker B; other site 714359013795 D-loop; other site 714359013796 H-loop/switch region; other site 714359013797 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 714359013798 LytTr DNA-binding domain; Region: LytTR; pfam04397 714359013799 Stage II sporulation protein; Region: SpoIID; pfam08486 714359013800 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 714359013801 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 714359013802 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 714359013803 hinge; other site 714359013804 active site 714359013805 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 714359013806 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 714359013807 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 714359013808 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 714359013809 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 714359013810 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 714359013811 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 714359013812 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 714359013813 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 714359013814 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 714359013815 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 714359013816 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 714359013817 4Fe-4S binding domain; Region: Fer4; cl02805 714359013818 4Fe-4S binding domain; Region: Fer4; pfam00037 714359013819 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 714359013820 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 714359013821 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 714359013822 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 714359013823 NADH dehydrogenase subunit C; Validated; Region: PRK07735 714359013824 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 714359013825 NADH dehydrogenase subunit B; Validated; Region: PRK06411 714359013826 NADH dehydrogenase subunit A; Validated; Region: PRK07756 714359013827 PAS domain S-box; Region: sensory_box; TIGR00229 714359013828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359013829 putative active site [active] 714359013830 heme pocket [chemical binding]; other site 714359013831 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714359013832 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359013833 metal binding site [ion binding]; metal-binding site 714359013834 active site 714359013835 I-site; other site 714359013836 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359013837 Protein of unknown function (DUF975); Region: DUF975; cl10504 714359013838 Protein of unknown function (DUF975); Region: DUF975; cl10504 714359013839 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 714359013840 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 714359013841 gamma subunit interface [polypeptide binding]; other site 714359013842 epsilon subunit interface [polypeptide binding]; other site 714359013843 LBP interface [polypeptide binding]; other site 714359013844 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 714359013845 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 714359013846 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 714359013847 alpha subunit interaction interface [polypeptide binding]; other site 714359013848 Walker A motif; other site 714359013849 ATP binding site [chemical binding]; other site 714359013850 Walker B motif; other site 714359013851 inhibitor binding site; inhibition site 714359013852 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 714359013853 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 714359013854 core domain interface [polypeptide binding]; other site 714359013855 delta subunit interface [polypeptide binding]; other site 714359013856 epsilon subunit interface [polypeptide binding]; other site 714359013857 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 714359013858 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 714359013859 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 714359013860 beta subunit interaction interface [polypeptide binding]; other site 714359013861 Walker A motif; other site 714359013862 ATP binding site [chemical binding]; other site 714359013863 Walker B motif; other site 714359013864 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 714359013865 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 714359013866 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 714359013867 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 714359013868 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 714359013869 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 714359013870 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 714359013871 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 714359013872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714359013873 active site 714359013874 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 714359013875 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 714359013876 dimer interface [polypeptide binding]; other site 714359013877 active site 714359013878 glycine-pyridoxal phosphate binding site [chemical binding]; other site 714359013879 folate binding site [chemical binding]; other site 714359013880 hypothetical protein; Provisional; Region: PRK13690 714359013881 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 714359013882 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 714359013883 Low molecular weight phosphatase family; Region: LMWPc; cd00115 714359013884 active site 714359013885 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 714359013886 HPr interaction site; other site 714359013887 glycerol kinase (GK) interaction site [polypeptide binding]; other site 714359013888 active site 714359013889 phosphorylation site [posttranslational modification] 714359013890 Predicted membrane protein [Function unknown]; Region: COG2259 714359013891 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 714359013892 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 714359013893 Predicted membrane protein [Function unknown]; Region: COG1971 714359013894 Domain of unknown function DUF; Region: DUF204; pfam02659 714359013895 Domain of unknown function DUF; Region: DUF204; pfam02659 714359013896 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 714359013897 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 714359013898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 714359013899 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 714359013900 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 714359013901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359013902 S-adenosylmethionine binding site [chemical binding]; other site 714359013903 peptide chain release factor 1; Validated; Region: prfA; PRK00591 714359013904 This domain is found in peptide chain release factors; Region: PCRF; smart00937 714359013905 RF-1 domain; Region: RF-1; pfam00472 714359013906 thymidine kinase; Provisional; Region: PRK04296 714359013907 transcription termination factor Rho; Provisional; Region: rho; PRK09376 714359013908 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 714359013909 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 714359013910 RNA binding site [nucleotide binding]; other site 714359013911 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 714359013912 multimer interface [polypeptide binding]; other site 714359013913 Walker A motif; other site 714359013914 ATP binding site [chemical binding]; other site 714359013915 Walker B motif; other site 714359013916 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 714359013917 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 714359013918 putative active site [active] 714359013919 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 714359013920 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 714359013921 hinge; other site 714359013922 active site 714359013923 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 714359013924 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 714359013925 intersubunit interface [polypeptide binding]; other site 714359013926 active site 714359013927 zinc binding site [ion binding]; other site 714359013928 Na+ binding site [ion binding]; other site 714359013929 Response regulator receiver domain; Region: Response_reg; pfam00072 714359013930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359013931 active site 714359013932 phosphorylation site [posttranslational modification] 714359013933 intermolecular recognition site; other site 714359013934 dimerization interface [polypeptide binding]; other site 714359013935 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 714359013936 CTP synthetase; Validated; Region: pyrG; PRK05380 714359013937 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 714359013938 Catalytic site [active] 714359013939 active site 714359013940 UTP binding site [chemical binding]; other site 714359013941 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 714359013942 active site 714359013943 putative oxyanion hole; other site 714359013944 catalytic triad [active] 714359013945 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 714359013946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359013947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359013948 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 714359013949 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 714359013950 FAD binding site [chemical binding]; other site 714359013951 homotetramer interface [polypeptide binding]; other site 714359013952 substrate binding pocket [chemical binding]; other site 714359013953 catalytic base [active] 714359013954 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 714359013955 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 714359013956 FAD binding site [chemical binding]; other site 714359013957 homotetramer interface [polypeptide binding]; other site 714359013958 substrate binding pocket [chemical binding]; other site 714359013959 catalytic base [active] 714359013960 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 714359013961 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 714359013962 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 714359013963 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 714359013964 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 714359013965 dimer interface [polypeptide binding]; other site 714359013966 active site 714359013967 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 714359013968 4Fe-4S binding domain; Region: Fer4; cl02805 714359013969 Cysteine-rich domain; Region: CCG; pfam02754 714359013970 Cysteine-rich domain; Region: CCG; pfam02754 714359013971 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 714359013972 PLD-like domain; Region: PLDc_2; pfam13091 714359013973 putative active site [active] 714359013974 catalytic site [active] 714359013975 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 714359013976 PLD-like domain; Region: PLDc_2; pfam13091 714359013977 putative active site [active] 714359013978 catalytic site [active] 714359013979 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 714359013980 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 714359013981 PAS domain S-box; Region: sensory_box; TIGR00229 714359013982 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714359013983 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359013984 metal binding site [ion binding]; metal-binding site 714359013985 active site 714359013986 I-site; other site 714359013987 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359013988 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 714359013989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359013990 non-specific DNA binding site [nucleotide binding]; other site 714359013991 salt bridge; other site 714359013992 sequence-specific DNA binding site [nucleotide binding]; other site 714359013993 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359013994 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359013995 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359013996 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 714359013997 active site 714359013998 Zn binding site [ion binding]; other site 714359013999 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359014000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359014001 active site 714359014002 phosphorylation site [posttranslational modification] 714359014003 intermolecular recognition site; other site 714359014004 dimerization interface [polypeptide binding]; other site 714359014005 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359014006 DNA binding residues [nucleotide binding] 714359014007 dimerization interface [polypeptide binding]; other site 714359014008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 714359014009 Histidine kinase; Region: HisKA_3; pfam07730 714359014010 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 714359014011 ATP binding site [chemical binding]; other site 714359014012 Mg2+ binding site [ion binding]; other site 714359014013 G-X-G motif; other site 714359014014 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 714359014015 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 714359014016 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359014017 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714359014018 Walker A/P-loop; other site 714359014019 ATP binding site [chemical binding]; other site 714359014020 Q-loop/lid; other site 714359014021 ABC transporter signature motif; other site 714359014022 Walker B; other site 714359014023 D-loop; other site 714359014024 H-loop/switch region; other site 714359014025 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 714359014026 active site 714359014027 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 714359014028 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 714359014029 Collagen binding domain; Region: Collagen_bind; pfam05737 714359014030 Collagen binding domain; Region: Collagen_bind; pfam05737 714359014031 Collagen binding domain; Region: Collagen_bind; pfam05737 714359014032 Collagen binding domain; Region: Collagen_bind; pfam05737 714359014033 Collagen binding domain; Region: Collagen_bind; pfam05737 714359014034 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014035 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014036 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014037 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014038 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014039 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014040 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 714359014041 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014042 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014043 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014044 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014045 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014046 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014047 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014048 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014049 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 714359014050 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014051 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014052 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014053 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014054 Cna protein B-type domain; Region: Cna_B; pfam05738 714359014055 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 714359014056 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 714359014057 PA/protease or protease-like domain interface [polypeptide binding]; other site 714359014058 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 714359014059 Peptidase family M28; Region: Peptidase_M28; pfam04389 714359014060 metal binding site [ion binding]; metal-binding site 714359014061 RNA polymerase sigma factor; Provisional; Region: PRK12522 714359014062 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359014063 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359014064 DNA binding residues [nucleotide binding] 714359014065 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 714359014066 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 714359014067 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 714359014068 active site 714359014069 HIGH motif; other site 714359014070 KMSK motif region; other site 714359014071 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 714359014072 tRNA binding surface [nucleotide binding]; other site 714359014073 anticodon binding site; other site 714359014074 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 714359014075 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 714359014076 putative dimer interface [polypeptide binding]; other site 714359014077 catalytic triad [active] 714359014078 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 714359014079 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 714359014080 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 714359014081 agmatinase; Region: agmatinase; TIGR01230 714359014082 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 714359014083 putative active site [active] 714359014084 Mn binding site [ion binding]; other site 714359014085 spermidine synthase; Provisional; Region: PRK00811 714359014086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359014087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359014088 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359014089 putative substrate translocation pore; other site 714359014090 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 714359014091 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 714359014092 DNA binding residues [nucleotide binding] 714359014093 putative dimer interface [polypeptide binding]; other site 714359014094 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 714359014095 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 714359014096 active site 714359014097 catalytic site [active] 714359014098 metal binding site [ion binding]; metal-binding site 714359014099 dimer interface [polypeptide binding]; other site 714359014100 Transglycosylase; Region: Transgly; pfam00912 714359014101 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 714359014102 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714359014103 YwhD family; Region: YwhD; pfam08741 714359014104 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 714359014105 Peptidase family M50; Region: Peptidase_M50; pfam02163 714359014106 active site 714359014107 putative substrate binding region [chemical binding]; other site 714359014108 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 714359014109 active site 1 [active] 714359014110 dimer interface [polypeptide binding]; other site 714359014111 hexamer interface [polypeptide binding]; other site 714359014112 active site 2 [active] 714359014113 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 714359014114 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359014115 Zn2+ binding site [ion binding]; other site 714359014116 Mg2+ binding site [ion binding]; other site 714359014117 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 714359014118 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 714359014119 intersubunit interface [polypeptide binding]; other site 714359014120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714359014121 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714359014122 Walker A/P-loop; other site 714359014123 ATP binding site [chemical binding]; other site 714359014124 Q-loop/lid; other site 714359014125 ABC transporter signature motif; other site 714359014126 Walker B; other site 714359014127 D-loop; other site 714359014128 H-loop/switch region; other site 714359014129 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 714359014130 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359014131 ABC-ATPase subunit interface; other site 714359014132 dimer interface [polypeptide binding]; other site 714359014133 putative PBP binding regions; other site 714359014134 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 714359014135 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359014136 ABC-ATPase subunit interface; other site 714359014137 dimer interface [polypeptide binding]; other site 714359014138 putative PBP binding regions; other site 714359014139 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 714359014140 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 714359014141 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 714359014142 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 714359014143 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 714359014144 putative heme peroxidase; Provisional; Region: PRK12276 714359014145 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 714359014146 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714359014147 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 714359014148 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 714359014149 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 714359014150 Ion channel; Region: Ion_trans_2; pfam07885 714359014151 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 714359014152 TrkA-N domain; Region: TrkA_N; pfam02254 714359014153 TrkA-C domain; Region: TrkA_C; pfam02080 714359014154 putative uracil/xanthine transporter; Provisional; Region: PRK11412 714359014155 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359014156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359014157 motif II; other site 714359014158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359014159 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 714359014160 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 714359014161 ligand binding site [chemical binding]; other site 714359014162 active site 714359014163 UGI interface [polypeptide binding]; other site 714359014164 catalytic site [active] 714359014165 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 714359014166 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 714359014167 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 714359014168 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359014169 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 714359014170 Walker A/P-loop; other site 714359014171 ATP binding site [chemical binding]; other site 714359014172 Q-loop/lid; other site 714359014173 ABC transporter signature motif; other site 714359014174 Walker B; other site 714359014175 D-loop; other site 714359014176 H-loop/switch region; other site 714359014177 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 714359014178 active site 714359014179 catalytic triad [active] 714359014180 oxyanion hole [active] 714359014181 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359014182 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359014183 DNA binding site [nucleotide binding] 714359014184 domain linker motif; other site 714359014185 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 714359014186 putative dimerization interface [polypeptide binding]; other site 714359014187 putative ligand binding site [chemical binding]; other site 714359014188 Predicted membrane protein [Function unknown]; Region: COG2364 714359014189 homoserine dehydrogenase; Provisional; Region: PRK06349 714359014190 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 714359014191 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 714359014192 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 714359014193 homoserine O-succinyltransferase; Provisional; Region: PRK05368 714359014194 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 714359014195 proposed active site lysine [active] 714359014196 conserved cys residue [active] 714359014197 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 714359014198 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 714359014199 homodimer interface [polypeptide binding]; other site 714359014200 substrate-cofactor binding pocket; other site 714359014201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359014202 catalytic residue [active] 714359014203 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 714359014204 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 714359014205 Cl- selectivity filter; other site 714359014206 Cl- binding residues [ion binding]; other site 714359014207 pore gating glutamate residue; other site 714359014208 dimer interface [polypeptide binding]; other site 714359014209 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 714359014210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359014211 active site 714359014212 motif I; other site 714359014213 motif II; other site 714359014214 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 714359014215 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714359014216 ligand binding site [chemical binding]; other site 714359014217 flexible hinge region; other site 714359014218 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 714359014219 azoreductase; Provisional; Region: PRK13556 714359014220 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359014221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359014222 active site 714359014223 phosphorylation site [posttranslational modification] 714359014224 intermolecular recognition site; other site 714359014225 dimerization interface [polypeptide binding]; other site 714359014226 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359014227 DNA binding residues [nucleotide binding] 714359014228 dimerization interface [polypeptide binding]; other site 714359014229 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 714359014230 GAF domain; Region: GAF; pfam01590 714359014231 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 714359014232 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 714359014233 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 714359014234 Histidine kinase; Region: HisKA_3; pfam07730 714359014235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359014236 ATP binding site [chemical binding]; other site 714359014237 Mg2+ binding site [ion binding]; other site 714359014238 G-X-G motif; other site 714359014239 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 714359014240 dimer interface [polypeptide binding]; other site 714359014241 substrate binding site [chemical binding]; other site 714359014242 ATP binding site [chemical binding]; other site 714359014243 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 714359014244 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714359014245 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359014246 metal binding site [ion binding]; metal-binding site 714359014247 active site 714359014248 I-site; other site 714359014249 Protein of unknown function (DUF466); Region: DUF466; pfam04328 714359014250 carbon starvation protein A; Provisional; Region: PRK15015 714359014251 Carbon starvation protein CstA; Region: CstA; pfam02554 714359014252 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 714359014253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359014254 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 714359014255 active site 714359014256 phosphorylation site [posttranslational modification] 714359014257 intermolecular recognition site; other site 714359014258 dimerization interface [polypeptide binding]; other site 714359014259 LytTr DNA-binding domain; Region: LytTR; pfam04397 714359014260 benzoate transport; Region: 2A0115; TIGR00895 714359014261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359014262 putative substrate translocation pore; other site 714359014263 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 714359014264 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 714359014265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714359014266 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 714359014267 Predicted membrane protein [Function unknown]; Region: COG2860 714359014268 UPF0126 domain; Region: UPF0126; pfam03458 714359014269 UPF0126 domain; Region: UPF0126; pfam03458 714359014270 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 714359014271 heme-binding site [chemical binding]; other site 714359014272 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359014273 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359014274 dimer interface [polypeptide binding]; other site 714359014275 putative CheW interface [polypeptide binding]; other site 714359014276 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 714359014277 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 714359014278 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 714359014279 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 714359014280 Ligand binding site; other site 714359014281 Putative Catalytic site; other site 714359014282 DXD motif; other site 714359014283 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 714359014284 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 714359014285 active site 714359014286 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 714359014287 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 714359014288 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 714359014289 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 714359014290 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 714359014291 Ligand binding site; other site 714359014292 Putative Catalytic site; other site 714359014293 DXD motif; other site 714359014294 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359014295 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359014296 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359014297 ABC transporter; Region: ABC_tran_2; pfam12848 714359014298 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359014299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359014300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359014301 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 714359014302 Protein export membrane protein; Region: SecD_SecF; cl14618 714359014303 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 714359014304 methionine sulfoxide reductase B; Provisional; Region: PRK00222 714359014305 SelR domain; Region: SelR; pfam01641 714359014306 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 714359014307 antiholin-like protein LrgB; Provisional; Region: PRK04288 714359014308 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 714359014309 two-component response regulator; Provisional; Region: PRK14084 714359014310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359014311 active site 714359014312 phosphorylation site [posttranslational modification] 714359014313 intermolecular recognition site; other site 714359014314 dimerization interface [polypeptide binding]; other site 714359014315 LytTr DNA-binding domain; Region: LytTR; pfam04397 714359014316 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 714359014317 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 714359014318 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 714359014319 Histidine kinase; Region: His_kinase; pfam06580 714359014320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359014321 ATP binding site [chemical binding]; other site 714359014322 Mg2+ binding site [ion binding]; other site 714359014323 G-X-G motif; other site 714359014324 benzoate transport; Region: 2A0115; TIGR00895 714359014325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359014326 putative substrate translocation pore; other site 714359014327 BCCT family transporter; Region: BCCT; pfam02028 714359014328 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 714359014329 active site 714359014330 dimer interface [polypeptide binding]; other site 714359014331 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 714359014332 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 714359014333 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 714359014334 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359014335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359014336 NAD(P) binding site [chemical binding]; other site 714359014337 active site 714359014338 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 714359014339 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 714359014340 UDP-glucose 4-epimerase; Region: PLN02240 714359014341 NAD binding site [chemical binding]; other site 714359014342 homodimer interface [polypeptide binding]; other site 714359014343 active site 714359014344 substrate binding site [chemical binding]; other site 714359014345 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 714359014346 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 714359014347 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 714359014348 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 714359014349 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714359014350 ATP binding site [chemical binding]; other site 714359014351 Mg++ binding site [ion binding]; other site 714359014352 motif III; other site 714359014353 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359014354 nucleotide binding region [chemical binding]; other site 714359014355 ATP-binding site [chemical binding]; other site 714359014356 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 714359014357 RNA binding site [nucleotide binding]; other site 714359014358 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 714359014359 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 714359014360 active site 714359014361 oligoendopeptidase F; Region: pepF; TIGR00181 714359014362 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 714359014363 active site 714359014364 Zn binding site [ion binding]; other site 714359014365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359014366 FeS/SAM binding site; other site 714359014367 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 714359014368 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714359014369 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 714359014370 HlyD family secretion protein; Region: HlyD_3; pfam13437 714359014371 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 714359014372 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 714359014373 putative active site [active] 714359014374 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359014375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359014376 Walker A/P-loop; other site 714359014377 ATP binding site [chemical binding]; other site 714359014378 Q-loop/lid; other site 714359014379 ABC transporter signature motif; other site 714359014380 Walker B; other site 714359014381 D-loop; other site 714359014382 H-loop/switch region; other site 714359014383 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 714359014384 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359014385 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714359014386 Walker A/P-loop; other site 714359014387 ATP binding site [chemical binding]; other site 714359014388 Q-loop/lid; other site 714359014389 ABC transporter signature motif; other site 714359014390 Walker B; other site 714359014391 D-loop; other site 714359014392 H-loop/switch region; other site 714359014393 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 714359014394 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 714359014395 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 714359014396 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 714359014397 protein binding site [polypeptide binding]; other site 714359014398 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 714359014399 YycH protein; Region: YycI; pfam09648 714359014400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 714359014401 YycH protein; Region: YycH; pfam07435 714359014402 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 714359014403 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 714359014404 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359014405 dimerization interface [polypeptide binding]; other site 714359014406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359014407 putative active site [active] 714359014408 heme pocket [chemical binding]; other site 714359014409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359014410 dimer interface [polypeptide binding]; other site 714359014411 phosphorylation site [posttranslational modification] 714359014412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359014413 ATP binding site [chemical binding]; other site 714359014414 Mg2+ binding site [ion binding]; other site 714359014415 G-X-G motif; other site 714359014416 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359014417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359014418 active site 714359014419 phosphorylation site [posttranslational modification] 714359014420 intermolecular recognition site; other site 714359014421 dimerization interface [polypeptide binding]; other site 714359014422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359014423 DNA binding site [nucleotide binding] 714359014424 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 714359014425 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 714359014426 GDP-binding site [chemical binding]; other site 714359014427 ACT binding site; other site 714359014428 IMP binding site; other site 714359014429 replicative DNA helicase; Provisional; Region: PRK05748 714359014430 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 714359014431 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 714359014432 Walker A motif; other site 714359014433 ATP binding site [chemical binding]; other site 714359014434 Walker B motif; other site 714359014435 DNA binding loops [nucleotide binding] 714359014436 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 714359014437 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 714359014438 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 714359014439 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 714359014440 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 714359014441 DHH family; Region: DHH; pfam01368 714359014442 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 714359014443 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 714359014444 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 714359014445 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 714359014446 dimer interface [polypeptide binding]; other site 714359014447 ssDNA binding site [nucleotide binding]; other site 714359014448 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359014449 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 714359014450 GTP-binding protein YchF; Reviewed; Region: PRK09601 714359014451 YchF GTPase; Region: YchF; cd01900 714359014452 G1 box; other site 714359014453 GTP/Mg2+ binding site [chemical binding]; other site 714359014454 Switch I region; other site 714359014455 G2 box; other site 714359014456 Switch II region; other site 714359014457 G3 box; other site 714359014458 G4 box; other site 714359014459 G5 box; other site 714359014460 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 714359014461 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 714359014462 Mechanosensitive ion channel; Region: MS_channel; pfam00924 714359014463 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 714359014464 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 714359014465 ParB-like nuclease domain; Region: ParB; smart00470 714359014466 KorB domain; Region: KorB; pfam08535 714359014467 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 714359014468 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 714359014469 P-loop; other site 714359014470 Magnesium ion binding site [ion binding]; other site 714359014471 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 714359014472 Magnesium ion binding site [ion binding]; other site 714359014473 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 714359014474 ParB-like nuclease domain; Region: ParBc; pfam02195 714359014475 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 714359014476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359014477 S-adenosylmethionine binding site [chemical binding]; other site 714359014478 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 714359014479 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 714359014480 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 714359014481 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 714359014482 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 714359014483 trmE is a tRNA modification GTPase; Region: trmE; cd04164 714359014484 G1 box; other site 714359014485 GTP/Mg2+ binding site [chemical binding]; other site 714359014486 Switch I region; other site 714359014487 G2 box; other site 714359014488 Switch II region; other site 714359014489 G3 box; other site 714359014490 G4 box; other site 714359014491 G5 box; other site 714359014492 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 714359014493 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 714359014494 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 714359014495 G-X-X-G motif; other site 714359014496 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 714359014497 RxxxH motif; other site 714359014498 OxaA-like protein precursor; Validated; Region: PRK02944 714359014499 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 714359014500 ribonuclease P; Reviewed; Region: rnpA; PRK00499 714359014501 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 714359014502 Uncharacterized conserved protein [Function unknown]; Region: COG1683 714359014503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359014504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714359014505 Predicted integral membrane protein [Function unknown]; Region: COG5658 714359014506 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 714359014507 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 714359014508 ATP-grasp domain; Region: ATP-grasp_4; cl17255 714359014509 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 714359014510 S-formylglutathione hydrolase; Region: PLN02442 714359014511 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 714359014512 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 714359014513 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 714359014514 substrate binding site [chemical binding]; other site 714359014515 catalytic Zn binding site [ion binding]; other site 714359014516 NAD binding site [chemical binding]; other site 714359014517 structural Zn binding site [ion binding]; other site 714359014518 dimer interface [polypeptide binding]; other site 714359014519 Predicted transcriptional regulators [Transcription]; Region: COG1733 714359014520 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 714359014521 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 714359014522 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 714359014523 catalytic residues [active] 714359014524 catalytic nucleophile [active] 714359014525 Presynaptic Site I dimer interface [polypeptide binding]; other site 714359014526 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 714359014527 Synaptic Flat tetramer interface [polypeptide binding]; other site 714359014528 Synaptic Site I dimer interface [polypeptide binding]; other site 714359014529 DNA binding site [nucleotide binding] 714359014530 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 714359014531 Sm and related proteins; Region: Sm_like; cl00259 714359014532 heptamer interface [polypeptide binding]; other site 714359014533 Sm1 motif; other site 714359014534 hexamer interface [polypeptide binding]; other site 714359014535 RNA binding site [nucleotide binding]; other site 714359014536 Sm2 motif; other site 714359014537 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 714359014538 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 714359014539 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 714359014540 multiple promoter invertase; Provisional; Region: mpi; PRK13413 714359014541 catalytic residues [active] 714359014542 catalytic nucleophile [active] 714359014543 Presynaptic Site I dimer interface [polypeptide binding]; other site 714359014544 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 714359014545 Synaptic Flat tetramer interface [polypeptide binding]; other site 714359014546 Synaptic Site I dimer interface [polypeptide binding]; other site 714359014547 DNA binding site [nucleotide binding] 714359014548 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 714359014549 DNA-binding interface [nucleotide binding]; DNA binding site 714359014550 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714359014551 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359014552 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 714359014553 Spore germination protein; Region: Spore_permease; cl17796 714359014554 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359014555 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 714359014556 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 714359014557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359014558 dimerization interface [polypeptide binding]; other site 714359014559 putative DNA binding site [nucleotide binding]; other site 714359014560 putative Zn2+ binding site [ion binding]; other site 714359014561 Predicted membrane protein [Function unknown]; Region: COG2323 714359014562 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 714359014563 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 714359014564 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359014565 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 714359014566 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 714359014567 multiple promoter invertase; Provisional; Region: mpi; PRK13413 714359014568 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 714359014569 catalytic residues [active] 714359014570 catalytic nucleophile [active] 714359014571 Presynaptic Site I dimer interface [polypeptide binding]; other site 714359014572 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 714359014573 Synaptic Flat tetramer interface [polypeptide binding]; other site 714359014574 Synaptic Site I dimer interface [polypeptide binding]; other site 714359014575 DNA binding site [nucleotide binding] 714359014576 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 714359014577 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 714359014578 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 714359014579 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 714359014580 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 714359014581 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359014582 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 714359014583 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 714359014584 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 714359014585 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 714359014586 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 714359014587 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 714359014588 putative active site [active] 714359014589 putative NTP binding site [chemical binding]; other site 714359014590 putative nucleic acid binding site [nucleotide binding]; other site 714359014591 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 714359014592 active site 714359014593 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 714359014594 ATP binding site [chemical binding]; other site 714359014595 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 714359014596 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714359014597 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359014598 Catalytic site [active] 714359014599 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 714359014600 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 714359014601 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 714359014602 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 714359014603 putative active site [active] 714359014604 putative NTP binding site [chemical binding]; other site 714359014605 putative nucleic acid binding site [nucleotide binding]; other site 714359014606 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 714359014607 active site 714359014608 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 714359014609 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359014610 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359014611 DNA binding residues [nucleotide binding] 714359014612 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 714359014613 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 714359014614 putative NTP binding site [chemical binding]; other site 714359014615 AAA domain; Region: AAA_31; pfam13614 714359014616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359014617 non-specific DNA binding site [nucleotide binding]; other site 714359014618 salt bridge; other site 714359014619 sequence-specific DNA binding site [nucleotide binding]; other site 714359014620 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 714359014621 DNA polymerase III subunit beta; Validated; Region: PRK05643 714359014622 putative DNA binding surface [nucleotide binding]; other site 714359014623 dimer interface [polypeptide binding]; other site 714359014624 beta-clamp/translesion DNA polymerase binding surface; other site 714359014625 beta-clamp/clamp loader binding surface; other site 714359014626 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 714359014627 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 714359014628 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 714359014629 nucleotide binding site [chemical binding]; other site 714359014630 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 714359014631 Replication-relaxation; Region: Replic_Relax; pfam13814 714359014632 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 714359014633 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 714359014634 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 714359014635 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 714359014636 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 714359014637 active site 714359014638 catalytic residues [active] 714359014639 DNA binding site [nucleotide binding] 714359014640 Int/Topo IB signature motif; other site 714359014641 Trp repressor protein; Region: Trp_repressor; cl17266 714359014642 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 714359014643 TcpE family; Region: TcpE; pfam12648 714359014644 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 714359014645 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 714359014646 putative active site [active] 714359014647 putative NTP binding site [chemical binding]; other site 714359014648 putative nucleic acid binding site [nucleotide binding]; other site 714359014649 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 714359014650 active site 714359014651 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 714359014652 AAA-like domain; Region: AAA_10; pfam12846 714359014653 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 714359014654 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 714359014655 Brain acid soluble protein 1 (BASP1 protein); Region: BASP1; pfam05466 714359014656 Protein of unknown function (DUF3295); Region: DUF3295; pfam11702 714359014657 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 714359014658 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 714359014659 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714359014660 catalytic residue [active] 714359014661 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 714359014662 NlpC/P60 family; Region: NLPC_P60; pfam00877 714359014663 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 714359014664 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 714359014665 RNA binding site [nucleotide binding]; other site 714359014666 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 714359014667 nucleophile elbow; other site 714359014668 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 714359014669 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 714359014670 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 714359014671 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 714359014672 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 714359014673 MPN+ (JAMM) motif; other site 714359014674 Zinc-binding site [ion binding]; other site 714359014675 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 714359014676 potential frameshift: common BLAST hit: gi|67078174|ref|YP_245794.1| myo-inositol catabolism protein 714359014677 KduI/IolB family; Region: KduI; pfam04962 714359014678 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 714359014679 active site 714359014680 catalytic residues [active] 714359014681 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 714359014682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359014683 non-specific DNA binding site [nucleotide binding]; other site 714359014684 salt bridge; other site 714359014685 sequence-specific DNA binding site [nucleotide binding]; other site 714359014686 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 714359014687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359014688 Walker A motif; other site 714359014689 ATP binding site [chemical binding]; other site 714359014690 Walker B motif; other site 714359014691 arginine finger; other site 714359014692 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714359014693 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714359014694 Probable transposase; Region: OrfB_IS605; pfam01385 714359014695 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714359014696 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 714359014697 DNA polymerase III subunit delta'; Validated; Region: PRK08058 714359014698 DNA polymerase III subunit delta'; Validated; Region: PRK08485 714359014699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714359014700 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714359014701 Probable transposase; Region: OrfB_IS605; pfam01385 714359014702 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714359014703 DNA topoisomerase III; Provisional; Region: PRK07726 714359014704 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 714359014705 active site 714359014706 putative interdomain interaction site [polypeptide binding]; other site 714359014707 putative metal-binding site [ion binding]; other site 714359014708 putative nucleotide binding site [chemical binding]; other site 714359014709 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 714359014710 domain I; other site 714359014711 DNA binding groove [nucleotide binding] 714359014712 phosphate binding site [ion binding]; other site 714359014713 domain II; other site 714359014714 domain III; other site 714359014715 nucleotide binding site [chemical binding]; other site 714359014716 catalytic site [active] 714359014717 domain IV; other site 714359014718 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 714359014719 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 714359014720 metal ion-dependent adhesion site (MIDAS); other site 714359014721 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 714359014722 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 714359014723 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 714359014724 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 714359014725 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359014726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359014727 TPR motif; other site 714359014728 binding surface 714359014729 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 714359014730 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 714359014731 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359014732 MarR family; Region: MarR_2; pfam12802 714359014733 Beta-lactamase; Region: Beta-lactamase; pfam00144 714359014734 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359014735 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359014736 MarR family; Region: MarR_2; pfam12802 714359014737 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 714359014738 catalytic residues [active] 714359014739 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 714359014740 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 714359014741 PYR/PP interface [polypeptide binding]; other site 714359014742 dimer interface [polypeptide binding]; other site 714359014743 TPP binding site [chemical binding]; other site 714359014744 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 714359014745 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 714359014746 TPP-binding site [chemical binding]; other site 714359014747 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 714359014748 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 714359014749 acyl-activating enzyme (AAE) consensus motif; other site 714359014750 AMP binding site [chemical binding]; other site 714359014751 active site 714359014752 CoA binding site [chemical binding]; other site 714359014753 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 714359014754 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 714359014755 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 714359014756 active site 714359014757 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 714359014758 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714359014759 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 714359014760 Walker A/P-loop; other site 714359014761 ATP binding site [chemical binding]; other site 714359014762 Q-loop/lid; other site 714359014763 ABC transporter signature motif; other site 714359014764 Walker B; other site 714359014765 D-loop; other site 714359014766 H-loop/switch region; other site 714359014767 Condensation domain; Region: Condensation; pfam00668 714359014768 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714359014769 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 714359014770 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 714359014771 acyl-activating enzyme (AAE) consensus motif; other site 714359014772 AMP binding site [chemical binding]; other site 714359014773 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359014774 Condensation domain; Region: Condensation; pfam00668 714359014775 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714359014776 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 714359014777 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 714359014778 acyl-activating enzyme (AAE) consensus motif; other site 714359014779 AMP binding site [chemical binding]; other site 714359014780 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359014781 Condensation domain; Region: Condensation; pfam00668 714359014782 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714359014783 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 714359014784 Condensation domain; Region: Condensation; pfam00668 714359014785 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714359014786 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 714359014787 acyl-activating enzyme (AAE) consensus motif; other site 714359014788 AMP binding site [chemical binding]; other site 714359014789 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359014790 Condensation domain; Region: Condensation; pfam00668 714359014791 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714359014792 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 714359014793 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 714359014794 acyl-activating enzyme (AAE) consensus motif; other site 714359014795 AMP binding site [chemical binding]; other site 714359014796 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359014797 Condensation domain; Region: Condensation; pfam00668 714359014798 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714359014799 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 714359014800 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 714359014801 acyl-activating enzyme (AAE) consensus motif; other site 714359014802 AMP binding site [chemical binding]; other site 714359014803 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714359014804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359014805 NAD(P) binding site [chemical binding]; other site 714359014806 active site 714359014807 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359014808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714359014809 Walker A/P-loop; other site 714359014810 ATP binding site [chemical binding]; other site 714359014811 Q-loop/lid; other site 714359014812 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359014813 ABC transporter signature motif; other site 714359014814 Walker B; other site 714359014815 D-loop; other site 714359014816 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714359014817 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 714359014818 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 714359014819 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 714359014820 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 714359014821 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359014822 dimerization interface [polypeptide binding]; other site 714359014823 putative DNA binding site [nucleotide binding]; other site 714359014824 putative Zn2+ binding site [ion binding]; other site 714359014825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714359014826 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714359014827 Probable transposase; Region: OrfB_IS605; pfam01385 714359014828 Transposase IS200 like; Region: Y1_Tnp; pfam01797 714359014829 PAS domain S-box; Region: sensory_box; TIGR00229 714359014830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359014831 putative active site [active] 714359014832 heme pocket [chemical binding]; other site 714359014833 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714359014834 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359014835 metal binding site [ion binding]; metal-binding site 714359014836 active site 714359014837 I-site; other site 714359014838 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359014839 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 714359014840 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 714359014841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 714359014842 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 714359014843 heme-binding site [chemical binding]; other site 714359014844 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359014845 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714359014846 dimer interface [polypeptide binding]; other site 714359014847 putative CheW interface [polypeptide binding]; other site 714359014848 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 714359014849 active site 714359014850 catalytic residues [active] 714359014851 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 714359014852 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 714359014853 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 714359014854 P loop; other site 714359014855 Nucleotide binding site [chemical binding]; other site 714359014856 DTAP/Switch II; other site 714359014857 Switch I; other site 714359014858 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 714359014859 P loop; other site 714359014860 Nucleotide binding site [chemical binding]; other site 714359014861 DTAP/Switch II; other site 714359014862 Switch I; other site 714359014863 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 714359014864 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 714359014865 Low molecular weight phosphatase family; Region: LMWPc; cd00115 714359014866 active site 714359014867 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 714359014868 arsenical-resistance protein; Region: acr3; TIGR00832 714359014869 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359014870 dimerization interface [polypeptide binding]; other site 714359014871 putative DNA binding site [nucleotide binding]; other site 714359014872 putative Zn2+ binding site [ion binding]; other site 714359014873 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 714359014874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359014875 Coenzyme A binding pocket [chemical binding]; other site 714359014876 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 714359014877 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 714359014878 amphipathic channel; other site 714359014879 Asn-Pro-Ala signature motifs; other site 714359014880 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 714359014881 B12 binding site [chemical binding]; other site 714359014882 Radical SAM superfamily; Region: Radical_SAM; pfam04055 714359014883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359014884 FeS/SAM binding site; other site 714359014885 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359014886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359014887 non-specific DNA binding site [nucleotide binding]; other site 714359014888 salt bridge; other site 714359014889 sequence-specific DNA binding site [nucleotide binding]; other site 714359014890 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359014891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359014892 TPR motif; other site 714359014893 binding surface 714359014894 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359014895 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359014896 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714359014897 Phosphate transporter family; Region: PHO4; pfam01384 714359014898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359014899 dimerization interface [polypeptide binding]; other site 714359014900 putative Zn2+ binding site [ion binding]; other site 714359014901 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 714359014902 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 714359014903 MarR family; Region: MarR_2; pfam12802 714359014904 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714359014905 Predicted permeases [General function prediction only]; Region: COG0701 714359014906 AAA ATPase domain; Region: AAA_16; pfam13191 714359014907 AAA domain; Region: AAA_22; pfam13401 714359014908 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 714359014909 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 714359014910 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359014911 metal-binding site [ion binding] 714359014912 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 714359014913 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359014914 metal-binding site [ion binding] 714359014915 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 714359014916 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359014917 metal-binding site [ion binding] 714359014918 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359014919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359014920 motif II; other site 714359014921 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 714359014922 putative homodimer interface [polypeptide binding]; other site 714359014923 putative homotetramer interface [polypeptide binding]; other site 714359014924 putative allosteric switch controlling residues; other site 714359014925 putative metal binding site [ion binding]; other site 714359014926 putative homodimer-homodimer interface [polypeptide binding]; other site 714359014927 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 714359014928 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 714359014929 metal binding site [ion binding]; metal-binding site 714359014930 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 714359014931 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 714359014932 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 714359014933 catalytic residues [active] 714359014934 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 714359014935 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 714359014936 dimerization interface [polypeptide binding]; other site 714359014937 VPS10 domain; Region: VPS10; smart00602 714359014938 Family description; Region: DsbD_2; pfam13386 714359014939 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 714359014940 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 714359014941 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 714359014942 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359014943 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359014944 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359014945 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 714359014946 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359014947 Bacterial SH3 domain; Region: SH3_3; pfam08239 714359014948 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 714359014949 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359014950 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359014951 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 714359014952 catalytic residues [active] 714359014953 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 714359014954 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 714359014955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359014956 substrate binding pocket [chemical binding]; other site 714359014957 membrane-bound complex binding site; other site 714359014958 hinge residues; other site 714359014959 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714359014960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359014961 dimer interface [polypeptide binding]; other site 714359014962 conserved gate region; other site 714359014963 putative PBP binding loops; other site 714359014964 ABC-ATPase subunit interface; other site 714359014965 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714359014966 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 714359014967 Walker A/P-loop; other site 714359014968 ATP binding site [chemical binding]; other site 714359014969 Q-loop/lid; other site 714359014970 ABC transporter signature motif; other site 714359014971 Walker B; other site 714359014972 D-loop; other site 714359014973 H-loop/switch region; other site 714359014974 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 714359014975 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 714359014976 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 714359014977 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 714359014978 Multicopper oxidase; Region: Cu-oxidase; pfam00394 714359014979 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 714359014980 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359014981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359014982 active site 714359014983 phosphorylation site [posttranslational modification] 714359014984 intermolecular recognition site; other site 714359014985 dimerization interface [polypeptide binding]; other site 714359014986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359014987 DNA binding site [nucleotide binding] 714359014988 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 714359014989 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359014990 dimerization interface [polypeptide binding]; other site 714359014991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359014992 dimer interface [polypeptide binding]; other site 714359014993 phosphorylation site [posttranslational modification] 714359014994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359014995 ATP binding site [chemical binding]; other site 714359014996 Mg2+ binding site [ion binding]; other site 714359014997 G-X-G motif; other site 714359014998 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 714359014999 stage II sporulation protein P; Region: spore_II_P; TIGR02867 714359015000 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 714359015001 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 714359015002 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 714359015003 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 714359015004 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359015005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359015006 active site 714359015007 phosphorylation site [posttranslational modification] 714359015008 intermolecular recognition site; other site 714359015009 dimerization interface [polypeptide binding]; other site 714359015010 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359015011 DNA binding site [nucleotide binding] 714359015012 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 714359015013 putative active site [active] 714359015014 Isochorismatase family; Region: Isochorismatase; pfam00857 714359015015 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 714359015016 catalytic triad [active] 714359015017 conserved cis-peptide bond; other site 714359015018 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015019 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015020 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015021 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015022 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015023 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015024 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015025 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015026 Domain of unknown function DUF11; Region: DUF11; cl17728 714359015027 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015028 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015029 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015030 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015031 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015032 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015033 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015034 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015035 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015036 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015037 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015038 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015039 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015040 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015041 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015042 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015043 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015044 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015045 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015046 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015047 conserved repeat domain; Region: B_ant_repeat; TIGR01451 714359015048 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 714359015049 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 714359015050 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 714359015051 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 714359015052 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359015053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359015054 non-specific DNA binding site [nucleotide binding]; other site 714359015055 salt bridge; other site 714359015056 sequence-specific DNA binding site [nucleotide binding]; other site 714359015057 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 714359015058 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 714359015059 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359015060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359015061 active site 714359015062 motif I; other site 714359015063 motif II; other site 714359015064 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359015065 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 714359015066 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714359015067 active site 714359015068 DNA binding site [nucleotide binding] 714359015069 Int/Topo IB signature motif; other site 714359015070 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 714359015071 DNA binding residues [nucleotide binding] 714359015072 Helix-turn-helix domain; Region: HTH_17; pfam12728 714359015073 hypothetical protein; Provisional; Region: PRK12856